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https://www.readbyqxmd.com/read/29859690/invited-review-current-production-trends-farm-structures-and-economics-of-the-dairy-sheep-and-goat-sectors
#1
G Pulina, M J Milán, M P Lavín, A Theodoridis, E Morin, J Capote, D L Thomas, A H D Francesconi, G Caja
Dairy small ruminants account for approximately 21% of all sheep and goats in the world, produce around 3.5% of the world's milk, and are mainly located in subtropical-temperate areas of Asia, Europe, and Africa. Dairy sheep are concentrated around the Mediterranean and Black Sea regions, where their dairy products are typical ingredients of the human diet. Dairy goats are concentrated in low-income, food-deficit countries of the Indian subcontinent, where their products are a key food source, but are also present in high-income, technologically developed countries...
May 30, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29705566/vinorelbine-cyclophosphamide-compared-to-cyclophosphamide-in-peripheral-blood-stem-cell-mobilization-for-multiple-myeloma
#2
Sanjay de Mel, Yunxin Chen, Adeline Lin, Teck Guan Soh, Melissa Ooi, Eng Soo Yap, Lara Kristina Sioco Donato, Nurul Aidah Abdul Halim, Joanna Mah, Karen Lim, Li Mei Poon, Belinda Tan, Yelly, Hui Li Lim, Liang Piu Koh, Bee Choo Tai, Zhaojin Chen, Wee Joo Chng, Satish Kumar Gopalakrishnan, Lip Kun Tan
BACKGROUND: High dose Cyclophosphamide (Cy) and Vinorelbine Cyclophosphamide (Vino-Cy) are stem cell (SC) mobilisation options for patients with multiple myeloma (MM). We present a comparison of mobilisation outcomes using these regimens. PATIENTS AND METHODS: Vino-Cy patients received Vinorelbine 25 mg/m2 on day 1, cyclophosphamide 1500 mg/m2 on day 2, and pegylated GCSF on day 4 or GCSF 10 mcg/kg/day from day 4 onwards. Cy patients were given cyclophosphamide 4000 mg/m2 on day 1 and GCSF10 mcg/kg/day from day 5 onwards...
April 23, 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/29507195/rare-variants-in-axonogenesis-genes-connect-three-families-with-sound-color-synesthesia
#3
Amanda K Tilot, Katerina S Kucera, Arianna Vino, Julian E Asher, Simon Baron-Cohen, Simon E Fisher
Synesthesia is a rare nonpathological phenomenon where stimulation of one sense automatically provokes a secondary perception in another. Hypothesized to result from differences in cortical wiring during development, synesthetes show atypical structural and functional neural connectivity, but the underlying molecular mechanisms are unknown. The trait also appears to be more common among people with autism spectrum disorder and savant abilities. Previous linkage studies searching for shared loci of large effect size across multiple families have had limited success...
March 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29466943/correction-to-jasmonate-mediated-defence-responses-unlike-salicylate-mediated-responses-are-involved-in-the-recovery-of-grapevine-from-bois-noir-disease
#4
Anna Rita Paolacci, Giulio Catarcione, Luisa Ederli, Claudia Zadra, Stefania Pasqualini, Maurizio Badiani, Rita Musetti, Simonetta Santi, Mario Ciaffi
Following publication of the original article [1], it came to the attention of the authors that they had omitted to acknowledge the University of Parma. The Acknowledgement section should read as follows: "The authors kindly acknowledge the University of Parma (Department of Chemistry, Life Sciences and Environmental Sustainability; formerly Department of Life Sciences/Evolutionary and Functional Biology) for the transfer of funds obtained from the Ager project: GIALLUMI DELLA VITE: TECNOLOGIE INNOVATIVE PER LA DIAGNOSI E LO STUDIO DELLE INTERAZIONI PIANTA/PATOGENO, BANDO AGER VITICOLTURA DA VINO"...
February 21, 2018: BMC Plant Biology
https://www.readbyqxmd.com/read/29463886/a-set-of-regulatory-genes-co-expressed-in-embryonic-human-brain-is-implicated-in-disrupted-speech-development
#5
Else Eising, Amaia Carrion-Castillo, Arianna Vino, Edythe A Strand, Kathy J Jakielski, Thomas S Scerri, Michael S Hildebrand, Richard Webster, Alan Ma, Bernard Mazoyer, Clyde Francks, Melanie Bahlo, Ingrid E Scheffer, Angela T Morgan, Lawrence D Shriberg, Simon E Fisher
Genetic investigations of people with impaired development of spoken language provide windows into key aspects of human biology. Over 15 years after FOXP2 was identified, most speech and language impairments remain unexplained at the molecular level. We sequenced whole genomes of nineteen unrelated individuals diagnosed with childhood apraxia of speech, a rare disorder enriched for causative mutations of large effect. Where DNA was available from unaffected parents, we discovered de novo mutations, implicating genes, including CHD3, SETD1A and WDR5...
February 20, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29365100/proteomic-analysis-of-foxp-proteins-reveals-interactions-between-cortical-transcription-factors-associated-with-neurodevelopmental-disorders
#6
Sara B Estruch, Sarah A Graham, Martí Quevedo, Arianna Vino, Dick H W Dekkers, Pelagia Deriziotis, Elliot Sollis, Jeroen Demmers, Raymond A Poot, Simon E Fisher
FOXP transcription factors play important roles in neurodevelopment, but little is known about how their transcriptional activity is regulated. FOXP proteins cooperatively regulate gene expression by forming homo- and hetero-dimers with each other. Physical associations with other transcription factors might also modulate the functions of FOXP proteins. However, few FOXP-interacting transcription factors have been identified so far. Therefore, we sought to discover additional transcription factors that interact with the brain-expressed FOXP proteins, FOXP1, FOXP2 and FOXP4, through affinity-purifications of protein complexes followed by mass spectrometry...
April 1, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29285223/a-carp-1-functional-mimetic-loaded-vitamin-e-tpgs-micellar-nano-formulation-for-inhibition-of-renal-cell-carcinoma
#7
Vino T Cheriyan, Hashem O Alsaab, Sreeja Sekhar, Caitlin Stieber, Prashant Kesharwani, Samaresh Sau, Magesh Muthu, Lisa A Polin, Edi Levi, Arun K Iyer, Arun K Rishi
Current treatments for Renal Cell Carcinoma (RCC) include a combination of surgery, targeted therapy, and immunotherapy. Emergence of resistant RCCs contributes to failure of drugs and poor prognosis, and thus warrants development of new and improved treatment options for RCCs. Here we generated and characterized RCC cells that are resistant to Everolimus, a frontline mToR-targeted therapy, and tested whether our novel class of CARP-1 functional mimetic (CFM) compounds inhibit parental and Everolimus-resistant RCC cells...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29217862/tracheostomal-myiasis-a-word-of-caution
#8
Rajeev Sharma, K Vino Barathi, Rahul Saini, Sushmita Bairagi, Deepa Rani
No abstract text is available yet for this article.
November 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29191802/peripheral-neuropathy-induced-by-microtubule-targeted-chemotherapies-insights-into-acute-injury-and-long-term-recovery
#9
Krystyna M Wozniak, James J Vornov, Ying Wu, Ying Liu, Valentina A Carozzi, Virginia Rodriguez-Menendez, Elisa Ballarini, Paola Alberti, Eleonora Pozzi, Sara Semperboni, Brett M Cook, Bruce A Littlefield, Kenichi Nomoto, Krista Condon, Sean Eckley, Christopher DesJardins, Leslie Wilson, Mary A Jordan, Stuart C Feinstein, Guido Cavaletti, Michael Polydefkis, Barbara S Slusher
Chemotherapy-induced peripheral neuropathy (CIPN) is a major cause of disability in cancer survivors. CIPN investigations in preclinical model systems have focused on either behaviors or acute changes in nerve conduction velocity (NCV) and amplitude, but greater understanding of the underlying nature of axonal injury and its long-term processes is needed as cancer patients live longer. In this study, we used multiple independent endpoints to systematically characterize CIPN recovery in mice exposed to the antitubulin cancer drugs eribulin, ixabepilone, paclitaxel, or vinorelbine at MTDs...
February 1, 2018: Cancer Research
https://www.readbyqxmd.com/read/28994197/in-vino-veritas-an-invitation-for-ambitious-collaborative-proteogenomics-campaigns-on-plant-and-animal-models
#10
Jean Armengaud
Vitis vinifera has been an emblematic plant for Humans since the Neolithic period. Human civilization has been shaped by its domestication as both its medicinal and nutritional values were exploited. It is now cultivated on all habitable continents, and more than 5 thousand varieties have been developed. A global passion for the art of wine fuels innovation and a profound desire for knowledge on this plant. The genome sequence of a homozygotic cultivar and several RNA-seq datasets on other varieties have been released paving the way to gaining further insight into its biology and tailoring improvements to varieties...
October 10, 2017: Proteomics
https://www.readbyqxmd.com/read/28817737/myc-mediates-cancer-stem-like-cells-and-emt-changes-in-triple-negative-breast-cancers-cells
#11
Shuping Yin, Vino T Cheryan, Liping Xu, Arun K Rishi, Kaladhar B Reddy
Women with triple negative breast cancer (TNBC) have poor prognosis compared to other breast cancer subtypes. There were several reports indicating racial disparity in breast cancer outcomes between African American (AA) and European American (EA) women. For example, the mortality rates of AA breast cancer patients were three times higher than of EA patients, even though, the incidence is lower in AA women. Our in vitro studies indicate that cancer stem-like cells (CSCs) derived from AA TNBC cell lines have significantly higher self-renewal potential (mammosphere formation) than CSCs derived from EA cell lines...
2017: PloS One
https://www.readbyqxmd.com/read/28698367/structure-of-the-arabidopsis-topless-corepressor-provides-insight-into-the-evolution-of-transcriptional-repression
#12
Raquel Martin-Arevalillo, Max H Nanao, Antoine Larrieu, Thomas Vinos-Poyo, David Mast, Carlos Galvan-Ampudia, Géraldine Brunoud, Teva Vernoux, Renaud Dumas, François Parcy
Transcriptional repression involves a class of proteins called corepressors that link transcription factors to chromatin remodeling complexes. In plants such as Arabidopsis thaliana, the most prominent corepressor is TOPLESS (TPL), which plays a key role in hormone signaling and development. Here we present the crystallographic structure of the Arabidopsis TPL N-terminal region comprising the LisH and CTLH (C-terminal to LisH) domains and a newly identified third region, which corresponds to a CRA domain. Comparing the structure of TPL with the mammalian TBL1, which shares a similar domain structure and performs a parallel corepressor function, revealed that the plant TPLs have evolved a new tetramerization interface and unique and highly conserved surface for interaction with repressors...
July 25, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28669180/polysaccharides-and-oligosaccharides-produced-on-malvar-wines-elaborated-with-torulaspora-delbrueckii-cli-918-and-saccharomyces-cerevisiae-cli-889-native-yeasts-from-d-o-vinos-de-madrid
#13
Margarita García, Rafael Apolinar-Valiente, Pascale Williams, Braulio Esteve-Zarzoso, Teresa Arroyo, Julia Crespo, Thierry Doco
Polysaccharides and oligosaccharides released into Malvar white wines elaborated through pure, mixed, and sequential cultures with Torulaspora delbrueckii CLI 918 and Saccharomyces cerevisiae CLI 889 native yeasts from D.O. "Vinos de Madrid" were studied. Both fractions from different white wines were separated by high-resolution size-exclusion chromatography. Glycosyl composition and wine polysaccharide linkages were determined by GC-EI-MS chromatography. Molar-mass distributions were determined by SEC-MALLS, and intrinsic viscosity was determined by differential viscometer...
August 9, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28516793/red-or-white-wine-consumption-effect-on-atherosclerosis-in-healthy-individuals-in-vino-veritas-study
#14
RANDOMIZED CONTROLLED TRIAL
M Taborsky, P Ostadal, T Adam, O Moravec, V Gloger, A Schee, T Skala
AIMS: Consumption of wine has a protective effect on cardiovascular diseases. Data from prospective, long-term, head-to-head comparisons of effects of different drinks on markers of atherosclerosis have been insufficient. METHODS AND RESULTS: In Vino Veritas (IVV) study is long-term, prospective, multi-centre, randomized trial comparing effects of red and white wine on atherosclerosis. 157 healthy subjects were randomized to white or red wine consumption for one year...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28095375/disappearing-in-the-night-an-overview-on-trade-and-legislation-of-night-monkeys-in-south-and-central-america
#15
Magdalena S Svensson, Sam Shanee, Noga Shanee, Flavia B Bannister, Laura Cervera, Giuseppe Donati, Maren Huck, Leandro Jerusalinsky, Cecilia P Juarez, Angela M Maldonado, Jesus Martinez Mollinedo, Pedro G Méndez-Carvajal, Miguel A Molina Argandoña, Antonietta D Mollo Vino, K A I Nekaris, Mika Peck, Jennifer Rey-Goyeneche, Denise Spaan, Vincent Nijman
The international trade in night monkeys (Aotus spp.), found throughout Central and South America, has been regulated by the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) since 1975. We present a quantitative analysis of this trade from all 9 range countries, over 4 decades, and compare domestic legislation to CITES regulations. Night monkeys were exported from 8 of the 9 habitat countries, totalling 5,968 live individuals and 7,098 specimens, with trade of live individuals declining over time...
2016: Folia Primatologica; International Journal of Primatology
https://www.readbyqxmd.com/read/27687593/carp-1-functional-mimetics-are-novel-inhibitors-of-drug-resistant-triple-negative-breast-cancers
#16
Vino T Cheriyan, Magesh Muthu, Ketan Patel, Sreeja Sekhar, Walajapet Rajeswaran, Scott D Larsen, Lisa Polin, Edi Levi, Mandip Singh, Arun K Rishi
Doxorubicin and Cisplatin are the frontline therapeutics for treatment of the triple negative breast cancers (TNBCs). Emergence of drug-resistance often contributes to failure of drugs and poor prognosis, and thus necessitates development of new and improved modalities to treat TNBCs. We generated and characterized chemotherapy-resistant TNBC cells following their culture in chronic presence of Doxorubicin or Cisplatin, and tested whether their viabilities were inhibited by a novel class of CARP- 1 functional mimetic (CFM) compounds...
November 8, 2016: Oncotarget
https://www.readbyqxmd.com/read/27638722/genetic-markers-as-therapeutic-target-in-rheumatoid-arthritis-a-game-changer-in-clinical-therapy
#17
REVIEW
A M Mohamed Thoufic Ali, S Vino
Rheumatoid arthritis (RA) is a chronic, inflammatory, multi-systemic autoimmune disease unremitted by genetic and environmental factors. The factors are crucial but inadequate in the development of disease; however, these factors can be representative of potential therapeutic targets and response to clinical therapy. Insights into the contribution of genetic risk factors are currently in progress with studies querying the genetic variation, their role in gene expression of coding and non-coding genes and other mechanisms of disease...
November 2016: Rheumatology International
https://www.readbyqxmd.com/read/27388853/burden-of-advanced-breast-cancer-for-patients-and-caregivers-in-europe-comparison-of-two-treatment-forms-of-vinorelbine-oral-and-intravenous
#18
MULTICENTER STUDY
Sandro Barni, Beata Freier, Isabel Garau, Jean-Loup Mouysset, Marcela Sediva, Claudio Zamagni, Gilles Berdeaux, Cecilia de Almeida Agudo
AIM: To assess the burden of disease associated with advanced breast cancer (ABC) treated with oral (VinO) or intravenous vinorelbine (VinIV) from the perspective of patients and caregivers in five European countries. METHODS: This was an observational, prospective, international, multicenter study. Patients were included in the study at the beginning of their second cycle of chemotherapy with vinorelbine and categorized into two groups depending on whether they received VinO or VinIV...
November 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27351196/a-common-cyfip1-variant-at-the-15q11-2-disease-locus-is-associated-with-structural-variation-at-the-language-related-left-supramarginal-gyrus
#19
Young Jae Woo, Tao Wang, Tulio Guadalupe, Rebecca A Nebel, Arianna Vino, Victor A Del Bene, Sophie Molholm, Lars A Ross, Marcel P Zwiers, Simon E Fisher, John J Foxe, Brett S Abrahams
Copy number variants (CNVs) at the Breakpoint 1 to Breakpoint 2 region at 15q11.2 (BP1-2) are associated with language-related difficulties and increased risk for developmental disorders in which language is compromised. Towards underlying mechanisms, we investigated relationships between single nucleotide polymorphisms (SNPs) across the region and quantitative measures of human brain structure obtained by magnetic resonance imaging of healthy subjects. We report an association between rs4778298, a common variant at CYFIP1, and inter-individual variation in surface area across the left supramarginal gyrus (lh...
2016: PloS One
https://www.readbyqxmd.com/read/27329782/raacfdb-rheumatoid-arthritis-ayurvedic-classical-formulations-database
#20
A M Mohamed Thoufic Ali, Aakash Agrawal, S Sajitha Lulu, A Mohana Priya, S Vino
ETHNOPHARMACOLOGICAL RELEVANCE: In the past years, the treatment of rheumatoid arthritis (RA) has undergone remarkable changes in all therapeutic modes. The present newfangled care in clinical research is to determine and to pick a new track for better treatment options for RA. Recent ethnopharmacological investigations revealed that traditional herbal remedies are the most preferred modality of complementary and alternative medicine (CAM). However, several ayurvedic modes of treatments and formulations for RA are not much studied and documented from Indian traditional system of medicine...
February 2, 2017: Journal of Ethnopharmacology
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