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Vino T Cheriyan, Magesh Muthu, Ketan Patel, Sreeja Sekhar, Walajapet Rajeswaran, Scott D Larsen, Lisa Polin, Edi Levi, Mandip Singh, Arun K Rishi
Doxorubicin and Cisplatin are the frontline therapeutics for treatment of the triple negative breast cancers (TNBCs). Emergence of drug-resistance often contributes to failure of drugs and poor prognosis, and thus necessitates development of new and improved modalities to treat TNBCs. We generated and characterized chemotherapy-resistant TNBC cells following their culture in chronic presence of Doxorubicin or Cisplatin, and tested whether their viabilities were inhibited by a novel class of CARP- 1 functional mimetic (CFM) compounds...
September 28, 2016: Oncotarget
A M Mohamed Thoufic Ali, S Vino
Rheumatoid arthritis (RA) is a chronic, inflammatory, multi-systemic autoimmune disease unremitted by genetic and environmental factors. The factors are crucial but inadequate in the development of disease; however, these factors can be representative of potential therapeutic targets and response to clinical therapy. Insights into the contribution of genetic risk factors are currently in progress with studies querying the genetic variation, their role in gene expression of coding and non-coding genes and other mechanisms of disease...
November 2016: Rheumatology International
Sandro Barni, Beata Freier, Isabel Garau, Jean-Loup Mouysset, Marcela Sediva, Claudio Zamagni, Gilles Berdeaux, Cecilia de Almeida Agudo
AIM: To assess the burden of disease associated with advanced breast cancer (ABC) treated with oral (VinO) or intravenous vinorelbine (VinIV) from the perspective of patients and caregivers in five European countries. METHODS: This was an observational, prospective, international, multicenter study. Patients were included in the study at the beginning of their second cycle of chemotherapy with vinorelbine and categorized into two groups depending on whether they received VinO or VinIV...
July 22, 2016: Current Medical Research and Opinion
Young Jae Woo, Tao Wang, Tulio Guadalupe, Rebecca A Nebel, Arianna Vino, Victor A Del Bene, Sophie Molholm, Lars A Ross, Marcel P Zwiers, Simon E Fisher, John J Foxe, Brett S Abrahams
Copy number variants (CNVs) at the Breakpoint 1 to Breakpoint 2 region at 15q11.2 (BP1-2) are associated with language-related difficulties and increased risk for developmental disorders in which language is compromised. Towards underlying mechanisms, we investigated relationships between single nucleotide polymorphisms (SNPs) across the region and quantitative measures of human brain structure obtained by magnetic resonance imaging of healthy subjects. We report an association between rs4778298, a common variant at CYFIP1, and inter-individual variation in surface area across the left supramarginal gyrus (lh...
2016: PloS One
Mohamed Thoufic Ali A M, Aakash Agrawal, S Sajitha Lulu, A Mohana Priya, S Vino
ETHNOPHARMACOLOGICAL RELEVANCE: In the past years, the treatment of rheumatoid arthritis (RA) has undergone remarkable changes in all therapeutic modes. The present newfangled care in clinical research is to determine and to pick a new track for better treatment options for RA. Recent ethnopharmacological investigations revealed that traditional herbal remedies are the most preferred modality of complementary and alternative medicine (CAM). However, several ayurvedic modes of treatments and formulations for RA are not much studied and documented from Indian traditional system of medicine...
June 18, 2016: Journal of Ethnopharmacology
A Carrion-Castillo, E van Bergen, A Vino, T van Zuijen, P F de Jong, C Francks, S E Fisher
Recent genome-wide association scans (GWAS) for reading and language abilities have pin-pointed promising new candidate loci. However, the potential contributions of these loci remain to be validated. In this study, we tested 17 of the most significantly associated single nucleotide polymorphisms (SNPs) from these GWAS studies (P < 10(-6) in the original studies) in a new independent population dataset from the Netherlands: known as Familial Influences on Literacy Abilities. This dataset comprised 483 children from 307 nuclear families and 505 adults (including parents of participating children), and provided adequate statistical power to detect the effects that were previously reported...
July 2016: Genes, Brain, and Behavior
Abdelkader E Ashour, Atallah F Ahmed, Ashok Kumar, Khairy M A Zoheir, Mourad A Aboul-Soud, Sheikh F Ahmad, Sabry M Attia, Adel R A Abd-Allah, Vino T Cheryan, Arun K Rishi
Medulloblastoma (MB) is the most common malignant brain tumor of childhood. The transcription factor NF-κB is overexpressed in human MB and is a critical factor for MB tumor growth. NF-κB is known to regulate the expression of interleukin-8 (IL-8), the chemokine that enhances cancer cell growth and resistance to chemotherapy. We have recently shown that thymoquinone (TQ) suppresses growth of hepatocellular carcinoma cells in part by inhibiting NF-κB signaling. Here we sought to extend these studies in MB cells and show that TQ suppresses growth of MB cells in a dose- and time-dependent manner, causes G2M cell cycle arrest, and induces apoptosis...
May 2016: Molecular and Cellular Biochemistry
C Pavlov, G Casazza, D Nikolova, C Gluud
No abstract text is available yet for this article.
May 2016: Alimentary Pharmacology & Therapeutics
M Thiele, A Krag
No abstract text is available yet for this article.
May 2016: Alimentary Pharmacology & Therapeutics
M García, D Greetham, T T Wimalasena, T G Phister, J M Cabellos, T Arroyo
AIMS: Climate change is exerting an increasingly profound effect on grape composition, microbiology, chemistry and the sensory aspects of wine. Identification of autochthonous yeasts tolerant to stress could help to alleviate this effect. METHODS AND RESULTS: Tolerance to osmotic pressure, ethanol and pH of 94 Saccharomyces cerevisiae strains and 29 strains non-Saccharomyces from the warm climate region DO 'Vinos de Madrid' (Spain) using phenotypic microarray and their fermentative behaviour were studied...
July 2016: Journal of Applied Microbiology
Murugan Rajalaxmi, Rajamohamed Beema Shafreen, Prasanth M Iyer, Raja Sahaya Vino, Krishnaswamy Balamurugan, Shunmugiah Karutha Pandian
Biofilm formation is a major contributing factor in the pathogenesis of Vibrio cholerae O1 (VCO1) and therefore preventing biofilm formation could be an effective alternative strategy for controlling cholera. The present study was designed to explore seawater bacteria as a source of anti-biofilm agents against VCO1. Indole-3-carboxaldehyde (I3C) was identified as an active principle component in Marinomonas sp., which efficiently inhibited biofilm formation by VCO1 without any selection pressure. Furthermore, I3C applications also resulted in considerable collapsing of preformed pellicles...
2016: Biofouling
Irene Stefanini, Davide Albanese, Agostino Cavazza, Elena Franciosi, Carlotta De Filippo, Claudio Donati, Duccio Cavalieri
Vino Santo is a sweet wine produced from late harvesting and pressing of Nosiola grapes in a small, well-defined geographical area in the Italian Alps. We used metagenomics to characterize the dynamics of microbial communities in the products of three wineries, resulting from spontaneous fermentation with almost the same timing and procedure. Comparing fermentation dynamics and grape microbial composition, we show a rapid increase in a small number of wine yeast species, with a parallel decrease in complexity...
March 2016: Microbial Biotechnology
Elliot Sollis, Sarah A Graham, Arianna Vino, Henning Froehlich, Maaike Vreeburg, Danai Dimitropoulou, Christian Gilissen, Rolph Pfundt, Gudrun A Rappold, Han G Brunner, Pelagia Deriziotis, Simon E Fisher
De novo disruptions of the neural transcription factor FOXP1 are a recently discovered, rare cause of sporadic intellectual disability (ID). We report three new cases of FOXP1-related disorder identified through clinical whole-exome sequencing. Detailed phenotypic assessment confirmed that global developmental delay, autistic features, speech/language deficits, hypotonia and mild dysmorphic features are core features of the disorder. We expand the phenotypic spectrum to include sensory integration disorder and hypertelorism...
February 1, 2016: Human Molecular Genetics
Pedro Rocha-Cabrera, María Reyes-Batlle, Carmen María Martín-Navarro, Alexis Dorta-Gorrín, Atteneri López-Arencibia, Ines Sifaoui, Enrique Martínez-Carretero, José E Piñero, Fernando Martín-Barrera, Basilio Valladares, Jacob Lorenzo-Morales
Pathogenic strains of Acanthamoeba are causative agents of a sight-threatening infection of the cornea known as Acanthamoeba keratitis, which is often associated with the misuse of contact lenses. However, there is still a question remaining to be answered, which is whether these micro-organisms are present on the ocular surface of healthy individuals. Therefore, the aim of this study was to determine the presence of Acanthamoeba on the ocular surface in healthy patients and also in those with other ocular surface infections...
August 2015: Journal of Medical Microbiology
Humberto Herman Lara, Eduardo Javier Alanís-Garza, María Fernanda Estrada Puente, Lucía Liliana Mureyko, David Alejandro Alarcón Torres, Liliana Ixtepan Turrent
Alzheimer's disease is the most common cause of dementia in the world; symptoms first appear after age 65 and have a progressive evolution. Expecting an increase on its incidence and knowing there is currently no cure for Alzheimer's disease, it is a necessity to prevent progression. The change in diet due to globalization may explain the growth of the incidence in places such as Japan and Mediterranean countries, which used to have fewer incidences. There is a direct correlation between disease progression and the increased intake of alcohol, saturated fats, and red meat...
March 2015: Gaceta Médica de México
Magesh Muthu, Vino T Cheriyan, Arun K Rishi
Targeted cancer therapy using small molecule inhibitors (SMIs) has been useful in targeting the tumor cells while sparing the normal cells. Despite clinical success of many targeted therapies, their off-target effects and development of resistance are emerging as significant and challenging problems. Thus, there is an urgent need to identify targets to devise new means to treat cancers and their drug-resistant phenotypes. CARP-1/CCAR1 (Cell division cycle and apoptosis regulator 1), a peri-nuclear phospho-protein, plays a dynamic role in regulating cell growth and apoptosis by serving as a co-activator of steroid/thyroid nuclear receptors, β-catenin, Anaphase Promoting Complex/Cyclosome (APC/C) E3 ligase, and tumor suppressor p53...
March 30, 2015: Oncotarget
Edward J Despott, Alberto Murino, Leonidas Bourikas, Masanao Nakamura, Vino Ramachandra, Chris Fraser
BACKGROUND: Spiral enteroscopy is a recently introduced technology alternative to balloon-assisted enteroscopy for examination of the small bowel. AIM: To compare small bowel insertion depths and procedure duration by spiral enteroscopy and double-balloon enteroscopy performed in the same cohort of patients, in immediate succession, using the same method of insertion depth estimation. METHODS: A prospective, back-to-back comparative study was performed in 15 patients...
May 2015: Digestive and Liver Disease
Reymundo Lozano, Arianna Vino, Cristina Lozano, Simon E Fisher, Pelagia Deriziotis
FOXP1 (forkhead box protein P1) is a transcription factor involved in the development of several tissues, including the brain. An emerging phenotype of patients with protein-disrupting FOXP1 variants includes global developmental delay, intellectual disability and mild to severe speech/language deficits. We report on a female child with a history of severe hypotonia, autism spectrum disorder and mild intellectual disability with severe speech/language impairment. Clinical exome sequencing identified a heterozygous de novo FOXP1 variant c...
December 2015: European Journal of Human Genetics: EJHG
S Sajitha Lulu, A Thabitha, S Vino, A Mohana Priya, Madhusmita Rout
Nonstructural proteins of hepatitis C virus had drawn much attention for the scientific fraternity in drug discovery due to its important role in the disease. 3D structure of the protein was predicted using molecular modelling protocol. Docking studies of 10 medicinal plant compounds and three drugs available in the market (control) with NS2 protease were employed by using rigid docking approach of AutoDock 4.2. Among the molecules tested for docking study, naringenin and quercetin revealed minimum binding energy of - 7...
2016: Natural Product Research
Kristina Suchotzki, Geert Crombez, Evelyne Debey, Kim van Oorsouw, Bruno Verschuere
AIMS: Despite the widespread belief that alcohol makes the truth come out more easily, we know very little on how alcohol impacts deception. Given that alcohol impairs response inhibition, and that response inhibition may be critically involved in deception, we expected that alcohol intake would hamper lying. METHODS: In total, 104 volunteers were tested at a science festival, where they had the opportunity to drink alcohol. Stop-Signal Reaction Times (SSRTs) served as operationalization of response inhibition...
January 2015: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
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