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https://www.readbyqxmd.com/read/28815036/bacterial-stimuli-activate-nitric-oxide-colonic-mucosal-production-in-diverticular-disease-protective-effects-of-l-casei-dg%C3%A2-lactobacillus-paracasei-cncm-i-1572
#1
Fabio Turco, Paolo Andreozzi, Ilaria Palumbo, Francesco Paolo Zito, Martina Cargiolli, Walter Fiore, Nicola Gennarelli, Giovanni Domenico De Palma, Giovanni Sarnelli, Rosario Cuomo
BACKGROUND: Micro-inflammation and changes in gut microbiota may play a role in the pathogenesis of diverticular disease (DD). OBJECTIVE: The objective of this article is to evaluate the expression of nitric oxide (NO)-related mediators and S100B in colonic mucosa of patients with DD in an ex vivo model of bacterial infection. METHODS: Intestinal biopsies obtained from patients with diverticulosis, symptomatic uncomplicated diverticular disease (SUDD) and SUDD with previous acute diverticulitis (SUDD+AD) were stimulated with the probiotic L...
August 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28814777/the-microbial-ecosystem-distinguishes-chronically-diseased-tissue-from-adjacent-tissue-in-the-sigmoid-colon-of-chronic-recurrent-diverticulitis-patients
#2
Kathleen M Schieffer, Kate Sabey, Justin R Wright, David R Toole, Rebecca Drucker, Vasily Tokarev, Leonard R Harris, Sue Deiling, Melanie A Eshelman, John P Hegarty, Gregory S Yochum, Walter A Koltun, Regina Lamendella, David B Stewart
Diverticular disease is commonly associated with the older population in the United States. As individual's age, diverticulae, or herniation of the mucosa through the colonic wall, develop. In 10-25% of individuals, the diverticulae become inflamed, resulting in diverticulitis. The gut ecosystem relies on the interaction of bacteria and fungi to maintain homeostasis. Although bacterial dysbiosis has been implicated in the pathogenesis of diverticulitis, associations between the microbial ecosystem and diverticulitis remain largely unstudied...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28808610/association-between-alcohol-consumption-and-diverticulosis-and-diverticular-bleeding-a-systematic-review-and-meta-analysis
#3
Veeravich Jaruvongvanich, Anawin Sanguankeo, Sikarin Upala
There have been conflicting reports on the association of alcohol use and diverticular disease. We aimed to determine the odds of developing diverticular disease and diverticular bleeding in patients who consumed alcohol on a regular basis compared with those who did not. MEDLINE and PUBMED were searched up until February 2017 on observational trials, which investigated the effect of alcohol use on two outcomes of diverticular disease: diverticulosis and diverticular bleeding. Quantitative estimates (odds ratios [OR] and confidence intervals [CI]) from included studies were pooled by using a random-effects model...
August 2017: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/28805779/-treatment-of-inflammatory-complications-of-colic-diverticular-disease-at-the-emergency-surgical-care-hospital
#4
P A Reznitsky, P A Yartsev, N V Shavrina
AIM: To assess an effectiveness of minimally invasive and laparoscopic technologies in treatment of inflammatory complications of colic diverticular disease. MATERIAL AND METHODS: The study included 150 patients who were divided into control and main groups. Survey included ultrasound, X-ray examination and abdominal computerized tomography. In the main group standardized treatment algorithm including minimally invasive and laparoscopic technologies was used. RESULTS: In the main group 79 patients underwent conservative treatment, minimally invasive (ultrasound-assisted percutaneous drainage of abscesses) and laparoscopic surgery that was successful in 78 (98...
2017: Khirurgiia
https://www.readbyqxmd.com/read/28768296/dietary-pattern-and-colonic-diverticulosis
#5
Antonio Tursi
PURPOSE OF REVIEW: To assess the role of dietary pattern on the occurrence of colonic diverticulosis, diverticular disease and acute diverticulitis. RECENT FINDINGS: High-fiber diet does not prevent diverticulosis occurrence, and results about prevention/treatment of diverticular disease and acute diverticulitis are still conflicting.No association was seen between nut, corn or popcorn consumption and occurrence of diverticulosis, diverticular disease and acute diverticulitis...
September 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/28764591/segmental-colectomy-for-bleeding-diverticular-disease-guided-by-the-peep-test
#6
Vijay Naraynsingh, Shamir O Cawich, Dale Hassranah, Feisal Daniel, Ravi Maharaj, Patrick Harnarayan
Many patients with massive lower gastrointestinal (GI) haemorrhage from diverticulosis are subjected to total colectomy when preoperative localisation is unavailable. We dissected colectomy specimens and noted that there was limited retrograde reflux in most of these cases. Therefore, we sought to assess the value of a positive endoluminal erythrocyte presence (PEEP) test (presence of fresh blood in the caecum) to direct segmental colectomies in 14 patients who required emergency operations for massive lower GI haemorrhage...
January 1, 2017: Tropical Doctor
https://www.readbyqxmd.com/read/28756358/jejunal-diverticula-with-perforation-in-non-steroidal-anti-inflammatory-drug-user-a-case-report
#7
Shobhit Gupta, Naveen Kumar
INTRODUCTION: Multiple diverticulosis of the jejunum constitutes an uncommon pathology of the small bowel. The disease is often asymptomatic and must be taken into consideration in cases of unexplained malabsorption, anemia, chronic abdominal pain and discomfort. CASE PRESENTAION: We are thereby reporting a 50yr patient on chronic NSAID ingestion presenting to us with acute abdomen. On exploration, there were multiple (14) jejunal diverticuli on both mesenteric and antimesentric border from 10cm to 90cm distal to duedenojejunal junction with a perforation in one of the diverticulum, 80cm distal to the ligament of Treitz...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28751521/the-third-pathway-of-colorectal-carcinogenesis
#8
REVIEW
Carlos A Rubio, Giacomo Puppa, Giovanni de Petris, Lorand Kis, Peter T Schmidt
AIMS: The majority of the colorectal carcinomas (CRC) arise in a vast mucosal area built with columnar cells and mucus-producing goblet cells. These carcinomas evolve via the conventional (tubular/villous) adenoma-carcinoma pathway, or the serrated adenoma-carcinoma pathway. Much less frequently CRC arise in the gut-associated lymphoid tissue (GALT) mucosal domain via the third pathway of colorectal carcinogenesis. METHODS: All publications on human colorectal GALT carcinomas in the literature were reviewed...
July 27, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28748737/emergency-hartmann-s-procedure-and-its-reversal-a-totally-laparoscopic-2-step-surgery-for-the-treatment-of-hinchey-iii-and-iv-diverticulitis
#9
Diletta Cassini, Michelangelo Miccini, Farshad Manoochehri, Matteo Gregori, Gianandrea Baldazzi
BACKGROUND: Hartmann's procedure (HP) followed by reversal restoration is the first choice for treatment of diffuse diverticular peritonitis. There is no unanimous consensus regarding the use of laparoscopy to treat the same condition. METHODS: Data from 60 patients with diverticular diffuse peritonitis who underwent urgent HP followed by laparoscopic reversal were retrospectively analyzed. Patients were divided into 2 groups according to the open or laparoscopic HP (OHP, 24 patients; LHP, 36 patients)...
July 1, 2017: Surgical Innovation
https://www.readbyqxmd.com/read/28745709/-diverticular-disease-of-small-intestine-complicated-by-perforation-and-advanced-peritonitis
#10
M R Imanaliev, Z Z Nazhmudinov, A G Guseynov, M A Magomedov, M G Saidov
No abstract text is available yet for this article.
2017: Khirurgiia
https://www.readbyqxmd.com/read/28737875/-intestinal-cystic-duplication-case-report
#11
Ana Herranz Barbero, Jordi Prat Ortells, M Elena Muñoz Fernández, Montserrat Castañón García-Alix, Josep Figueras Aloy
Intestinal cystic duplications are rare congenital anomalies, with an estimated incidence of approximately 1:4500 autopsies. The etiopathogenesis is uncertain. These duplications are cystic, tubular or diverticular structures lined with gastrointestinal mucosa. They share a common smooth muscle wall with the gastrointestinal tract but usually their lumens do not communicate with each other. Gastric duplication cysts represent 7-9% of the gastrointestinal tract duplication. They can be diagnosed prenatally by fetal ultrasound; magnetic resonance imaging characterizes the cyst and excludes other malformations...
August 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28737647/risk-factors-for-30-day-hospital-readmission-for-diverticular-hemorrhage
#12
Jonah N Rubin, Daniel Shoag, John N Gaetano, Dejan Micic, Neil Sengupta
INTRODUCTION: The 2010 Affordable Care Act introduced the Hospital Readmissions Reduction Program to reduce health care utilization. Diverticular disease and its complications remain a leading cause of hospitalization among gastrointestinal disease. We sought to determine risk factors for 30-day hospital readmissions after hospitalization for diverticular bleeding. MATERIALS AND METHODS: We utilized the 2013 National Readmission Database sponsored by the Agency for Healthcare Research and Quality focusing on hospitalizations with the primary or secondary discharge diagnosis of diverticular hemorrhage or diverticulitis with hemorrhage...
July 21, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28732299/enterovesical-fistula-a-rare-complication-of-meckel-s-diverticulum-a-case-report
#13
Bourguiba M A, Gharbi M, Ghalleb M, Ben Taher A, Souai F, Bensafta Y, Sayari S, Ben Moussa M
INTRODUCTION: Enterovesical fistulas usually result from diverticulitis, Crohn's disease, or colorectal cancer. A perforated Meckel's diverticulum can exceptionally result in an vesico-diverticulum fistula, as noted in only seven previously reported cases. CASE REPORT: A 35-year old Arabic male, quadriplegic,who presented epigastralgia evolving for a week, associated with abdominal distension and cloudy urine. On examination he was feverish (38.5°C), dehydrated with tenderness in the entire distended abdomen; rectal examination revealed a hypotonic sphincter with no other abnormality...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28728207/-female-urethral-diverticulum-with-calculus-formation-imitating-stress-incontinence
#14
Leonidas Karapanos, Daniel Porres, David Pfister, Ilgar Akbarov, Axel Heidenreich, Vahudin Zugor
A female urethral diverticulum (UD) is a rare condition with a prevalence of 0.6 - 4.7 %. Possible aetiologies include chronic infection of the periurethral glands, childbirth trauma, and iatrogenic lesions after urethral manipulation. The main symptoms are recurrent urinary tract infections, post-void dribbling and leakage of urine or purulent discharge by movement, which is caused by the emptying of the diverticular lumen (paradoxical incontinence). As this may imitate stress urinary incontinence, the final diagnosis is a challenge for urologists...
July 20, 2017: Aktuelle Urologie
https://www.readbyqxmd.com/read/28723691/high-cost-of-hospitalization-for-colonic-diverticular-bleeding-depended-on-repeated-bleeding-and-blood-transfusion-analysis-with-diagnosis-procedure-combination-data-in-japan
#15
Yoichiro Ito, Yasuhisa Sakata, Hisako Yoshida, Sayuri Nonaka, Susumu Fujii, Yuichiro Tanaka, Shimpei Shirai, Eri Takeshita, Takashi Akutagawa, Hiroharu Kawakubo, Koji Yamamoto, Nanae Tsuruoka, Ryo Shimoda, Ryuichi Iwakiri, Kazuma Fujimoto
BACKGROUND: Bleeding from a colonic diverticulum is serious in aged patients. The aim of this study was to determine the risk factors for high-cost hospitalization of colonic diverticular bleeding using the diagnosis procedure combination (DPC) data. METHODS: From January 2009 to December 2015, 78 patients with colonic diverticular bleeding were identified by DPC data in Saga Medical School Hospital. All patients underwent colonic endoscopy within 3 days. The patients were divided into 2 groups: the low-cost group (DPC cost of <500,000 yen) and the high-cost group (DPC cost of >500,000 yen)...
July 20, 2017: Digestion
https://www.readbyqxmd.com/read/28702105/the-effect-of-cyclic-rifaximin-therapy-on-symptoms-of-diverticular-disease-from-the-perspective-of-the-gastroenterology-outpatient-clinic-a-real-life-study
#16
Andrzej Moniuszko, Grażyna Rydzewska
INTRODUCTION: Symptomatic uncomplicated diverticular disease of the colon (SUDD) is one of the most common diseases with which patients present to a gastroenterologist. Mild forms of diverticulitis can also be treated using rifaximin. Although numerous randomised controlled trials have already demonstrated the efficacy of rifaximin therapy, there is still a lack of data from daily medical practice. AIM: To assess the effect of rifaximin on the symptoms of diverticular disease (SUDD and mild diverticulitis) in patients undergoing routine treatment in gastroenterology outpatient clinics in Poland...
2017: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/28698087/computational-fluid-dynamics-simulation-of-hemodynamic-alterations-in-sigmoid-sinus-diverticulum-and-ipsilateral-upstream-sinus-stenosis-after-stent-implantation-in-patients-with-pulsatile-tinnitus
#17
Yanjing Han, Qingqing Yang, Zeran Yang, Jun Xia, Tianhao Su, Long Jin, Aike Qiao, Jianan Yu
OBJECTIVE: To investigate the relationships between upstream venous sinus stenosis and pulsatile tinnitus (PT), and to assess the correlation with diverticulum growth and the effectiveness of stent implantation METHODS: A patient-specific geometric models were constructed using computed tomography venography images from a patient with PT with sigmoid sinus diverticulum(SSD) and upstream transverse sinus stenosis, in whom stenting of the upstream sinus stenosis alone achieved complete remission of PT...
July 8, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28698005/meckel-s-diverticulum-in-the-adult
#18
J Lequet, B Menahem, A Alves, A Fohlen, A Mulliri
Meckel's diverticulum (MD) is the most common gastro-intestinal congenital malformation (approximately 2% in the overall population). The lifetime risk of related complications is estimated at 4%. These include gastro-intestinal bleeding, obstruction or diverticular inflammation. Diagnosis is difficult and rarely made, and imaging, especially in the case of complicated disease, is often not helpful; however exploratory laparoscopy is an important diagnostic tool. The probability of onset of complication decreases with age, and the diagnosis of MD in the adult is therefore often incidental...
July 8, 2017: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/28683448/gut-microbiota-in-health-diverticular-disease-irritable-bowel-syndrome-and-inflammatory-bowel-diseases-time-for-microbial-marker-of-gastrointestinal-disorders
#19
Loris Riccardo Lopetuso, Valentina Petito, Cristina Graziani, Elisa Schiavoni, Francesco Paroni Sterbini, Andrea Poscia, Eleonora Gaetani, Francesco Franceschi, Giovanni Cammarota, Maurizio Sanguinetti, Luca Masucci, Franco Scaldaferri, Antonio Gasbarrini
Few data exist on differences in gut microbiota composition among principal gastrointestinal (GI) diseases. We evaluated the differences in gut microbiota composition among uncomplicated diverticular disease (DD), irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD) patients. DD, IBS, and IBD patients along with healthy controls (CT) were enrolled in our Italian GI outpatient clinic. Stool samples were collected. Microbiota composition was evaluated through a metagenomic gene-targeted approach...
July 7, 2017: Digestive Diseases
https://www.readbyqxmd.com/read/28663067/economic-burden-of-diverticular-disease-an-observational-analysis-based-on-real-world-data-from-an-italian-region
#20
F S Mennini, P Sciattella, A Marcellusi, B Toraldo, M Koch
INTRODUCTION: Diverticular disease (DD), a herniation of the colonic mucosa through the muscle layer, covers a wide variety of conditions associated with the presence of diverticula in the colon. The most serious form is an acute episode of diverticulitis, which can lead to hospitalization and surgery with various types of consequences. The main aim of this study is to evaluate the economic burden of hospitalizations arising from acute episodes of diverticulitis using data from the administrative databases used in the Marche region in Italy and, as a secondary objective of this real-world data analysis, to study patient outcome variables following initial hospitalization for diverticulitis...
June 8, 2017: Digestive and Liver Disease
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