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https://www.readbyqxmd.com/read/28528364/a-randomized-double-blind-placebo-controlled-trial-of-a-multi-strain-probiotic-in-treatment-of-symptomatic-uncomplicated-diverticular-disease
#1
Charlotte L Kvasnovsky, Ingvar Bjarnason, Ana Nora Donaldson, Roy A Sherwood, Savvas Papagrigoriadis
BACKGROUND: Diverticular disease is a significant burden on healthcare systems that is managed, surgically or medically, mainly as an emergency or acute condition. There are no standardized treatment recommendations for symptomatic uncomplicated disease. We hypothesized that a probiotic would reduce abdominal pain in such patients. METHODS: We conducted a single-center, double-blind, placebo-controlled trial of probiotic treatment (Symprove) in adult patients with moderate-to-severe chronic, non-acute symptomatic diverticular disease...
May 20, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28523327/complicated-diverticulitis-in-a-de-novo-kidney-transplanted-patient
#2
Liliana Ana TuŢă, Mădălina Boşoteanu, Eugen Dumitru, Mariana Deacu
Diverticular disease is frequent amongst the elderly and immunosuppressed patients. It mainly presents as sigmoid diverticulitis, but severe complications, like bleedings, infections and colon perforation may occur, frequently due to immunosuppressive therapy. Moreover, antibiotherapy and hemostatics may not efficiently control evolution in such cases. Early diagnose and adequate treatment of colonic diverticulosis complicated with lower gastrointestinal bleeding and diverticulitis in immunocompromised patients...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28506073/duodenal-diverticular-bleeding-an-endoscopic-challenge
#3
Eduardo Valdivielso Cortázar, Lucía Madarnás Alonso, Susana Ortíz Marín, Ignacio Couto Worner, Pedro Alonso Aguirre
Duodenal diverticula are an uncommon cause of upper gastrointestinal bleeding. Until recently, it was primarily managed with surgery, but advances in the field of endoscopy have made management increasingly less invasive. We report a case of duodenal diverticular bleeding that was endoscopically managed, and review the literature about the various endoscopic therapies thus far described.
May 16, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28503973/metformin-use-in-diabetics-with-diverticular-disease-is-associated-with-reduced-incidence-of-diverticulitis
#4
Julia Freckelton, Jacqueline Amanda Evans, Daniel Croagh, Gregory Thomas Moore
BACKGROUND AND AIMS: There is no current, evidence-based therapy to prevent acute diverticulitis in patients with diverticular disease. Metformin has been shown to have anti-inflammatory effects in a number of disease states, in both animal models and in human observational studies. The potential therapeutic efficacy of metformin in diverticular disease has not been investigated. This study aims to describe the relationship between metformin use and diverticular disease in patients with diabetes mellitus...
May 14, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28494576/diverticular-disease-an-update-on-pathogenesis-and-management
#5
REVIEW
Mona Rezapour, Saima Ali, Neil Stollman
Diverticular disease is one of the most common conditions in the Western world and one of the most common findings identified at colonoscopy. Recently, there has been a significant paradigm shift in our understanding of diverticular disease and its management. The pathogenesis of diverticular disease is thought to be multifactorial and include both environmental and genetic factors in addition to the historically accepted etiology of dietary fiber deficiency. Symptomatic uncomplicated diverticular disease (SUDD) is currently considered a type of chronic diverticulosis that is perhaps akin to irritable bowel syndrome...
May 12, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28483573/percutaneous-management-of-stone-containing-calyceal-diverticula-associated-factors-and-outcomes
#6
Egor Parkhomenko, Timothy Tran, Julie Thai, Kyle Blum, Mantu Gupta
PURPOSE: We evaluated the outcomes of percutaneous treatment and metabolic evaluation of calyceal diverticula with associated stones. MATERIALS & METHODS: We retrospectively identified 51 calyceal diverticula patients from our prospectively maintained percutaneous nephrolithotomy database. Patients with complete data were separated into those with stones isolated to their diverticulum (TicStone, n=14), and those who also had renal stones outside the diverticulum (TicStone+, n=15)...
May 5, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28479765/management-of-renal-caliceal-diverticular-stones-a-decade-of-experience
#7
Madhusudan Patodia, Rahul Janak Sinha, Siddharth Singh, Vishwajeet Singh
OBJECTIVE: The objective of this study is to evaluate our methods for management of renal caliceal diverticular stones (CDS). MATERIALS AND METHODS: We conducted a retrospective study from January 2005 to July 2015 and included patients who were treated for renal CDS. Patients were evaluated for treatment modality, puncture site (in case percutaneous nephrolithotomy [PCNL] attempted), operative time, stone clearance rate, and complications. During PCNL, if the infundibulum was found to connect the diverticulum to the calyx, then a double J stent was placed...
April 2017: Urology Annals
https://www.readbyqxmd.com/read/28469355/segmental-colitis-associated-with-diverticulosis-is-it-the-coexistence-of-colonic-diverticulosis-and-inflammatory-bowel-disease
#8
REVIEW
John Schembri, John Bonello, Dimitrios K Christodoulou, Konstantinos H Katsanos, Pierre Ellul
Segmental colitis associated with diverticulosis (SCAD) is an inflammatory process that affects colonic luminal mucosa in segments that are also affected by diverticulosis. Its prevalence varies between 1.15% and 11.4% amongst those suffering from diverticular disease (DD). Being closely associated with DD, it is slightly commoner in males and usually presents in the sixth decade of life. Although the exact pathogenesis of SCAD is unknown, it is probably heterogeneous and includes mechanisms that also play a part in inflammatory bowel disease (IBD)...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/28467330/diagnosis-of-symptomatic-uncomplicated-diverticular-disease-and-the-role-of-rifaximin-in-management
#9
Giovanni Maconi
 Patients with diverticulosis who develop persistent abdominal pain, bloating and changes in bowel habits not associated with overt inflammation may have symptomatic uncomplicated diverticular disease (SUDD). The severity and frequency of SUDD symptoms may have an impact on daily activities and severely affect quality of life. Effective management of SUDD should follow a three part strategy: divert, tackle and maintain. Divert to make the correct diagnosis: several symptoms of SUDD are common to other conditions that require different therapeutic approaches...
April 28, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/28467190/risk-of-gastrointestinal-bleeding-during-anticoagulant-treatment
#10
Aitor Lanas-Gimeno, Angel Lanas
Gastrointestinal bleeding (GIB) is a major problem in patients on oral anticoagulation therapy. This issue has become even more pressing since the introduction of direct oral anticoagulants (DOACs) in 2009. Areas Covered: Here we review current evidence related to GIB associated with oral anticoagulants, focusing on randomized controlled trials, meta-analyses, and post-marketing observational studies. Dabigatran 150 mg twice daily and rivaroxaban 20 mg once daily increase the risk of GIB compared to warfarin...
May 3, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28466633/the-current-management-of-diverticulosis
#11
Walter Elisei, Giovanni Brandimarte, Antonio Tursi
The incidence of diverticulosis and diverticular disease of the colon, including acute diverticulitis, is increasing worldwide, and becoming a significant burden on national health systems in terms of direct and indirect costs. Thus, significant efforts are now being focused to identify the correct therapeutic approach to treat symptomatic patients and to prevent diverticulitis. Fibre, non- absorbable antibiotics, 5-aminosalicylic acid and probioticsare currently being investigated in this way. Unfortunately, current evidences on the effectiveness of some medical treatment in preventing acute diverticulitis recurrence are still lacking...
May 2, 2017: Minerva Medica
https://www.readbyqxmd.com/read/28463672/genito-urinary-function-and-quality-of-life-after-elective-totally-laparoscopic-sigmoidectomy-after-at-least-one-episode-of-complicated-diverticular-disease-according-to-two-different-vascular-approaches-the-ima-low-ligation-or-the-ima-preservation
#12
Giulio Mari, Jacopo Crippa, Andrea Costanzi, Michele Mazzola, Carmelo Magistro, Giovanni Ferrari, Dario Maggioni
The arterial ligation during elective laparoscopic sigmoidectomy for diverticular disease can affect genito-urinary function injuring the superior hypogastric plexus, and can weaken the distal colonic stump arterial perfusion. Ligation of the inferior mesenteric artery distal to the left colic artery or the complete preservation of the inferior mesenteric artery can therefore be compared in terms of preservation of the descending sympathetic fibres running along the aorta to the rectum resulting in a different post operative genito urinary function...
March 2017: Chirurgia
https://www.readbyqxmd.com/read/28461904/corticosteroid-use-and-mortality-risk-in-patients-with-perforated-colonic-diverticular-disease-a-population-based-cohort-study
#13
L H A Broersen, E Horváth-Puhó, A M Pereira, R Erichsen, O M Dekkers, H T Sørensen
BACKGROUND: Corticosteroids are a potential risk factor for mortality in patients with perforated diverticular disease, due to blinding of disease severity, hampered wound healing or adrenal insufficiency. We examined mortality in corticosteroid users and non-users among patients with perforated diverticular disease. METHODS: A cohort study based on medical databases including all patients ≥18 years in Denmark (source population 5 289 261 inhabitants) admitted to a hospital with incident perforated diverticular disease between 2005 and 2013...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/28458843/sigmoid-gluteal-fistula-a-rare-complication-of-fistulating-diverticular-disease
#14
Thomas Chadwick, Ashok Katti, James Arthur
A rare complication of diverticular disease is the formation of fistulas, most commonly either colo-vesical or colo-vaginal. We present the unusual case of a perforated sigmoid diverticulum forming a colo-gluteal fistula and presenting initially as a gluteal abscess in an otherwise asymptomatic patient. After drainage of the gluteal abscess, the patient re-presented with faecal loss from the abscess drainage site. Imaging revealed fistulous communication between the sigmoid and the left obturator internus muscle, tracking to the gluteus maximus with associated abscess and cutaneous communication to the site of previous drainage...
March 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28457170/an-adult-case-of-kommerell-s-diverticulum-with-a-right-sided-aortic-arch
#15
Koji Tsutsumi, Kosuke Nishida, Jun Tsukamoto, Natsumi Iijima, Osamu Ishida
The patient was a 56-year-old woman with Kommerell's diverticulum associated with a right-sided aortic arch with mirror-image branching. No other congenital heart anomalies or vascular rings were observed. Descending aortic replacement through a right posterolateral thoracotomy was performed to eliminate the risk of diverticular rupture. The patient's postoperative course was uneventful. This was a rare adult case of right-sided aortic arch with Kommerell's diverticulum associated with no other congenital heart disease...
January 1, 2017: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/28453588/-diverticular-disease-myths-and-realities
#16
Daniela Fluxá, Rodrigo Quera
Diverticulosis and diverticular disease of the colon are common conditions in Western countries. The incidence and prevalence of these diseases are increasing and becoming significant for health systems. A growing body of knowledge is shifting the paradigm of the pathogenesis and treatment of diverticular disease. Low-grade inflammation, altered intestinal microbiota, visceral hypersensitivity, and abnormal colonic motility have been identified as factors leading to diverticular disease. The risk of developing diverticulitis among individuals with diverticulosis is lower than 10 to 25%...
February 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28450063/diverticulitis-diagnosed-in-the-emergency-room-is-it-safe-to-discharge-home
#17
Anne-Marie E Sirany, Wolfgang B Gaertner, Robert D Madoff, Mary R Kwaan
BACKGROUND: Inpatient treatment of patients with colon diverticulitis represents a significant financial and clinical burden to the healthcare system and patients. The aim of this study was compare patients with diverticulitis in the emergency department (ED) who were discharged to home versus admitted to the hospital. STUDY DESIGN: We reviewed all patients evaluated in the ED of a metropolitan health system with the primary diagnosis of diverticulitis (ICD9 562...
March 7, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28447967/management-of-colovesical-and-colovaginal-diverticular-fistulas-our-experience-and-literature-reviewed
#18
Tommaso Marcucci, Sandro Giannessi, Francesco Giudici, Sara Riccadonna, Agnese Gori, Francesco Tonelli
AIM: This study aims evaluate the effectiveness of various surgical techniques in treating diverticular fistulas, and the safety and efficacy of the laparoscopic procedure comparing our results with those of the literature. MATERIAL OF STUDY: This was a prospective and uncontrolled study performed at a general surgery units. Between 2005 and 2011, 16 patients (11 men, 5 women) underwent surgery for diverticular fistulas. The mean age was 70.2 (range, 35-87) years...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28440847/diafragmabr%C3%A3-ck-ledde-till-kolonileus-med-sekund%C3%A3-r-mediastinal-%C3%A3-verskjutning-ovanligt-fall-visar-att-hiatusbr%C3%A3-ck-m%C3%A3-ste-tas-p%C3%A3-allvar
#19
Victor Mill, Claes Brodin
Large bowel obstruction with effects on the mediastinum We present a patient in which the colon and left kidney herniated through a left-sided diaphragmatic hernia. The cause of the hernia was unknown, although most likely it emanated from an earlier diaphragmatic rupture caused by trauma. Due to a diverticular stenosis of the sigmoid colon, the patient developed large bowel obstruction, causing displacement of mediastinal structures. Emergency laparotomy and anterolateral thoracotomy was performed.
April 19, 2017: Läkartidningen
https://www.readbyqxmd.com/read/28438753/complicated-small-bowel-diverticular-disease-a-case-series
#20
Linden Karas, Mohammed Asif, Victor Chun, Farrukh A Khan
Small bowel diverticulosis of the jejunum and ileum is an uncommon finding with a prevalence rate of 0.2% to 1.3% at autopsy and 0.3% to 1.9% on small bowel studies. Diagnosis can be difficult because there are no pathognomonic features or clinical symptoms that are specific for small bowel diverticulosis. Though rare, it is critical to keep the possibility of small bowel diverticulosis in mind when evaluating cases of malabsorption, chronic abdominal pain, haemorrhage, perforation and intestinal obstruction, especially in patients with connective tissue disorders, a family history of diverticula and a personal history of colonic diverticulosis...
April 23, 2017: BMJ Case Reports
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