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https://www.readbyqxmd.com/read/28368880/critical-questions-regarding-gadolinium-deposition-in-the-brain-and-body-after-injections-of-the-gadolinium-based-contrast-agents-safety-and-clinical-recommendations-in-consideration-of-the-ema-s-pharmacovigilance-and-risk-assessment-committee-recommendation
#1
Val M Runge
For magnetic resonance, the established class of intravenous contrast media is the gadolinium-based contrast agents. In the 3 decades since initial approval, these have proven in general to be very safe for human administration. However, in 2006, a devastating late adverse reaction to administration of the less stable gadolinium-based contrast agents was identified, nephrogenic systemic fibrosis. The result of actions taken by the European Medicines Agency and the US Food and Drug Administration, stratifying the agents by risk and contraindicating specific agents in severe renal dysfunction, has led to no new cases being identified in North America or Europe...
June 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28144867/removal-of-gadolinium-based-contrast-agents-adsorption-on-activated-carbon
#2
María P Elizalde-González, Esmeralda García-Díaz, Mario González-Perea, Jürgen Mattusch
Three carbon samples were employed in this work, including commercial (1690 m(2) g(-1)), activated carbon prepared from guava seeds (637 m(2) g(-1)), and activated carbon prepared from avocado kernel (1068 m(2) g(-1)), to study the adsorption of the following gadolinium-based contrast agents (GBCAs): gadoterate meglumine Dotarem®, gadopentetate dimeglumine Magnevist®, and gadoxetate disodium Primovist®. The activation conditions with H3PO4 were optimized using a Taguchi methodology to obtain mesoporous materials...
March 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27755934/case-235-hepatic-adenomatosis-due-to-inflammatory-adenomas
#3
Gavin Low, Harini Dharmana, Samantha Saravana-Bawan, Safwat Girgis
History An asymptomatic 33-year-old woman was referred to the Hepatology Department in 2013 for work-up of indeterminate multifocal liver masses. These lesions were discovered incidentally at multiphase contrast material-enhanced multidetector computed tomography (CT) performed in 2004 to investigate right lower quadrant pain. Imaging surveillance at sporadic intervals revealed slow progressive growth of the lesions over time; however, the number of lesions remained constant. There was no history of cancer, nor were there predisposing factors for chronic liver disease or cirrhosis...
November 2016: Radiology
https://www.readbyqxmd.com/read/27684824/diagnostic-performance-of-gadoxetic-acid-primovist-enhanced-mr-imaging-versus-ct-during-hepatic-arteriography-and-portography-for-small-hypervascular-hepatocellular-carcinoma
#4
COMPARATIVE STUDY
Sun Young Yim, Beom Jin Park, Soon Ho Um, Na Yeon Han, Deuk Jae Sung, Sung Bum Cho, Seung Hwa Lee, Min Ju Kim, Jin Yong Jung, Jin Dong Kim, Yeon Seok Seo, Dong Sik Kim, Hyonggin An, Yun Hwan Kim
To compare the diagnostic performance of gadoxetic acid-enhanced magnetic resonance imaging (MRI) with that of computed tomography (CT) during hepatic arteriography and arterial portography (CT HA/AP) for detecting hepatocellular carcinoma (HCC) from small hypervascular nodules.This retrospective study included 38 patients with 131 hypervascular nodules (≤2 cm) who had underwent MRI and CT HA/AP within a 2-week interval. Two observers analyzed MRI while other 2 observers analyzed CT HA/AP. Thereafter, MRI observers reviewed the CT HA/AP and magnetic resonance (MR) images again using both modalities...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27652261/immediate-adverse-reactions-to-gadolinium-based-mr-contrast-media-a-retrospective-analysis-on-10-608-examinations
#5
Vincenza Granata, Marco Cascella, Roberta Fusco, Nicoletta dell'Aprovitola, Orlando Catalano, Salvatore Filice, Vincenzo Schiavone, Francesco Izzo, Arturo Cuomo, Antonella Petrillo
Background and Purpose. Contrast media (CM) for magnetic resonance imaging (MRI) may determine the development of acute adverse reactions. Objective was to retrospectively assess the frequency and severity of adverse reactions associated with gadolinium-based contrast agents (GBCAs) injection in patients who underwent MRI. Material and Methods. At our center 10608 MRI examinations with CM were performed using five different GBCAs: Gd-BOPTA (MultiHance), Gd-DTPA (Magnevist), Gd-EOBDTPA (Primovist), Gd-DOTA (Dotarem), and Gd-BTDO3A (Gadovist)...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27633531/gadoxetate-disodium-gd-eob-dtpa-contrast-enhanced-magnetic-resonance-imaging-characteristics-of-hepatocellular-carcinoma-in-dogs
#6
Chase Constant, Silke Hecht, Linden E Craig, Cassie N Lux, Claire M Cannon, Gordon A Conklin
Hepatocellular carcinoma is the most common primary hepatic tumor in dogs and is amenable to surgical resection in many cases. Unfortunately, overlap of sonographic findings between benign and malignant hepatic lesions typically requires more invasive diagnostic tests to be performed (e.g., biopsy for histopathology). The availability of a noninvasive diagnostic test to identify hepatocellular carcinoma would be beneficial. The use of a liver-specific magnetic resonance imaging (MRI) contrast agent such as gadoxetate disodium (Gd-EOB-DTPA; Eovist® or Primovist®) has improved lesion detection in human patients...
November 2016: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/27332047/clinical-effect-of-add-on-primovist-enhanced-magnetic-resonance-imaging-on-preoperative-tumor-staging-in-hepatocellular-carcinoma-patients
#7
MULTICENTER STUDY
Young-Joo Jin, Jin-Woo Lee, Oh Sang Kwon, Young Kul Jung, Jung Hyun Kwon, Jeong Won Jang, Young Seok Kim, Tae Hun Kim, Yong Sun Jeon
BACKGROUND/AIMS: We analyzed the incidence of change of Barcelona Clinic Liver Cancer (BCLC) stage after add-on Primovist-enhanced magnetic resonance imaging (MRI) in hepatocellular carcinoma (HCC) patients with Barcelona Clinic Liver Cancer stage 0 or A as determined by liver dynamic computed tomography (LDCT). METHODS: A total of 166 patients enrolled prospectively between August 2012 and December 2014 were retrospectively analyzed. The rates of stage change after Primovist-enhanced MRI and the treatment finally adopted in patients with stage change were evaluated...
July 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27100719/role-of-mri-with-hepatospecific-contrast-agent-in-the-identification-and-characterization-of-focal-liver-lesions-pathological-correlation-in-explanted-livers
#8
Antonio Orlacchio, Fabrizio Chegai, Sebastiano Fabiano, Stefano Merolla, Valentina Funel, Francesca Di Giuliano, Matteo Manuelli, Giuseppe Tisone, Simona Francioso, Mario Angelico, Giampiero Palmieri, Giovanni Simonetti
AIM: To assess the diagnostic performance of magnetic resonance imaging (MRI) with gadoxetic acid in the identification of hepatocellular carcinoma (HCC) nodules by comparison with histological findings. METHODS: In a cohort of patients suffering from cirrhosis of various etiologies (chronic hepatitis C virus (HCV) or hepatitis B virus (HBV), alcohol abuse, cryptogenic forms), we selected 17 patients affected by HCC who were eligible for liver transplantation on the basis of a computed-tomography (CT) total-body examination...
July 2016: La Radiologia Medica
https://www.readbyqxmd.com/read/27017170/colorectal-liver-metastases-disappearing-lesions-in-the-era-of-eovist-hepatobiliary-magnetic-resonance-imaging
#9
Joseph W Owen, Kathryn J Fowler, Maria B Doyle, Nael E Saad, David C Linehan, William C Chapman
BACKGROUND: Hepatobiliary contrast enhanced MRI is known to be the most sensitive imaging modality for detection of colorectal hepatic metastasis. To date no study has investigated the rate of disappearing lesions with gadoxetic acid MR (Eovist/Primovist), or characterized the pathologic response of lesions which disappear on gadoxetic acid MR. METHODS: Retrospective review of hepatic resections for colorectal metastases between 01/2008 and 01/2014 was performed to evaluated the rate of disappearance of lesions on gadoxetic acid MR and the rate of complete pathologic response in the lesions that disappear...
March 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/26345332/irreversible-electroporation-of-hepatocellular-carcinoma-preliminary-report-on-the-diagnostic-accuracy-of-magnetic-resonance-computer-tomography-and-contrast-enhanced-ultrasound-in-evaluation-of-the-ablated-area
#10
Vincenza Granata, Elisabetta de Lutio di Castelguidone, Roberta Fusco, Orlando Catalano, Mauro Piccirillo, Raffaele Palaia, Francesco Izzo, Adolfo D'Errico Gallipoli, Antonella Petrillo
OBJECTIVE: Irreversible electroporation (IRE) is a new ablation modality. Our purpose was to describe the effectiveness and the safety of the treatment and to evaluate the magnetic resonance imaging (MRI), computed tomography (CT) and contrast-enhanced ultrasound (CEUS) diagnostic accuracy in HCC patients treated with IRE at 1-, 3-, and 6-month follow-up. MATERIALS AND METHODS: In an 18-month period, we treated 24 HCC lesions in 20 patients unfit for surgery. MRI, CT and CEUS were performed before and one, 3 and 6 month after IRE...
February 2016: La Radiologia Medica
https://www.readbyqxmd.com/read/26258662/prospective-diagnostic-test-accuracy-comparison-of-computed-tomography-during-arterial-portography-and-primovist-magnetic-resonance-imaging-in-the-pre-operative-assessment-of-colorectal-cancer-liver-metastases
#11
COMPARATIVE STUDY
Jai S Bagia, Alan Chai, Roger Chou, Christopher Chu, John Rouse, Elizabeth Sinclair, Leon Vonthethoff, Armando Teixeira-Pinto
OBJECTIVES: To assess and compare the accuracy and inter-observer agreement for the detection of liver lesions using Primovist magnetic resonance imaging (pMRI) and computed tomography during arterial portography (CTAP). METHODS: Patients evaluated at St George Hospital Liver Unit for colorectal liver metastases (CRCLM) underwent CTAP as part of standard staging. pMRI was added to the pre-operative assessment. Two radiologists reported CTAP and two reported pMRI...
October 2015: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/26154554/liver-specific-magnetic-resonance-contrast-medium-in-the-evaluation-of-chronic-liver-disease
#12
REVIEW
Marcio Augusto Correia Rodrigues dos Reis, Ronaldo Hueb Baroni
The hepatobiliary-specific contrast medium (gadoxetic acid - Primovist®) is primarily used to improve detection and characterization of focal hepatic lesions, such as in chronic liver disease patients with suspected hepatocellular carcinoma. Since the contrast medium is selectively taken up by functioning hepatocytes in the late hepatobiliary phase, it helps to detect typical hepatocellular carcinoma, which show low signal intensity on this phase. This imaging feature also assists in differentiating regenerative/dysplastic nodules from early hepatocellular carcinomas (with over 90% accuracy), as well as hypervascular hepatocellular carcinomas from arterial pseudo-enhancement foci...
April 2015: Einstein
https://www.readbyqxmd.com/read/26048848/safety-of-gadoxetate-disodium-results-from-six-clinical-phase-iv-studies-in-8194-patients
#13
MULTICENTER STUDY
Jan Endrikat, So Yeon Kim, Toshiaki Sakaguchi, Susan Dohanish, Josy Breuer
Background Safety data on routine clinical use of gadoxetate disodium for liver magnetic resonance imaging (MRI) is not reported yet. Purpose To assess the safety profile of gadoxetate disodium for liver MRI in the routine clinical setting. Material and Methods Six multicenter studies were performed in Europe, USA, Australia, and Asia to evaluate the safety and efficacy of gadoxetate disodium (Primovist®/Eovist®) enhanced liver MRI. Patients received a single intravenous bolus injection of the standard approved dose of 0...
November 2016: Acta Radiologica
https://www.readbyqxmd.com/read/25925288/functional-assessment-of-the-liver-with-gadolinium-ethoxybenzyl-diethylenetriamine-penta-acetate-enhanced-mri-in-living-donor-liver-transplantation
#14
M Ninomiya, K Shirabe, H Kayashima, T Ikegami, A Nishie, N Harimoto, Y Yamashita, T Yoshizumi, H Uchiyama, Y Maehara
BACKGROUND: A precise estimation of the capacity of the remnant liver following partial liver resection is important. In this study, the regional function of the liver in patients undergoing living-donor liver transplantation was evaluated by gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid (EOB)-enhanced MRI, with special reference to the congested region. METHODS: EOB-MRI analysis was performed before hepatectomy in donors, and 7 days after surgery in the donor and recipient...
July 2015: British Journal of Surgery
https://www.readbyqxmd.com/read/25056714/value-of-gadoxetate-biliary-transit-time-in-determining-hepatocyte-function
#15
Jianwei Wu, Hui Li, Yuning Lin, Ziqian Chen, Qun Zhong, Hong Gao, Liyuan Fu, Kumar Sandrasegaran
OBJECTIVE: To determine if transit time for excretion of gadoxetate into major bile ducts and duodenum correlates with clinical models of hepatocellular function. METHODS: This retrospective research was approved by the Institutional Review Board with waiver of informed consent. Search of the radiology database from January 1, 2013 to March 4, 2014 revealed 84 patients with chronic liver disease (65 males, mean age 47 years). Eighteen control subjects with no known liver disease or risk factors were also enrolled for analysis (9 males, mean age 43 years)...
January 2015: Abdominal Imaging
https://www.readbyqxmd.com/read/24365398/interference-of-gadolinium-based-contrast-agents-on-colorimetric-calcium-assays
#16
Ronald Yan, Heather Tarr, Martin McNally, Louis-Jacques Cartier, Yu Chen
OBJECTIVE: The aim of this study was to evaluate the potential interference of five gadolinium-based contrast agents (GBCAs), gadodiamide (Omniscan®), gadobenate dimeglumine (Multihance®), gadoxetate disodium (Primovist®), gadobutrol (Gadovist®), and gadoteridol (Prohance®), on three clinical laboratory widely used colorimetric calcium assays including the newly developed 5-nitro-5'methyl-l,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (NM-BAPTA) method. METHODS: Plasma was collected from healthy volunteers aged 23-52, and spiked with varying concentrations of the five GBCAs...
May 2014: Clinical Biochemistry
https://www.readbyqxmd.com/read/24357463/the-liverpool-uveal-melanoma-liver-metastases-pathway-outcome-following-liver-resection
#17
D Gomez, C Wetherill, J Cheong, L Jones, E Marshall, B Damato, S E Coupland, P Ghaneh, G J Poston, H Z Malik, S W Fenwick
AIM: To determine the outcome of patients that underwent liver resection for metastases from uveal melanoma. METHODS: Over a 9-year period, patients referred with uveal melanoma metastases were included. Following treatment of primary uveal melanoma, high-risk patients were offered to be enrolled into a 6-monthly non-contrast liver magnetic resonance imaging (MRI) surveillance. Following detection of liver metastases, patients were staged with a contrast-enhanced (Primovist(®)) liver MRI, computer tomography (CT) of the thorax and staging laparoscopy...
May 2014: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/24267331/photo-cured-pmma-pei-core-shell-nanoparticles-surface-modified-with-gd-dtpa-for-t1-mr-imaging
#18
Montri Ratanajanchai, Don Haeng Lee, Panya Sunintaboon, Su-Geun Yang
Herein, we introduced amine-functionalized core-shell nanoparticles (Polymethyl methacrylate/Polyethyleneimine; PMMA/PEI) with surface primary amines (3.15×10(5) groups/particle) and uniform size distribution (150-200nm) that were prepared by one-step photo-induced emulsion polymerization. Further PEI-surface was modified with diethylenetriamine pentaacetic acid (DTPA) and introduced with Gd(III). The modified particles possessing DTPA can entrap a high content of Gd(III) ions of over 5.5×10(4)Gd/particle with stable chelation (no release of free Gd) at least 7h...
February 1, 2014: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/24056116/characterization-of-the-intestinal-and-hepatic-uptake-efflux-transport-of-the-magnetic-resonance-imaging-contrast-agent-gadolinium-ethoxylbenzyl-diethylenetriamine-pentaacetic-acid
#19
Jia Jia, Dorothee Puls, Stefan Oswald, Gabriele Jedlitschky, Jens P Kühn, Werner Weitschies, Norbert Hosten, Werner Siegmund, Markus Keiser
OBJECTIVES: The objectives of the study were to measure the pharmacokinetics and liver enhancement of gadoxetate (gadolinium-ethoxylbenzyl-diethylenetriamine-pentaacetic acid [Gd-EOB-DTPA], Eovist, Primovist) after oral and intravenous administration in wild-type and (multidrug resistance-associated protein 2) Mrp2-deficient rats and to evaluate the in vitro transport of the contrast agent via intestinal and hepatic transporter proteins. MATERIALS AND METHODS: Gadolinium-ethoxylbenzyl-diethylenetriamine-pentaacetic acid-enhanced magnetic resonance imaging and pharmacokinetics of Gd-EOB-DTPA after intravenous and oral administration were evaluated in wild-type and Mrp2-deficient rats using T1-weighted magnetic resonance imaging and a validated liquid chromatography-mass spectrometry method, respectively...
February 2014: Investigative Radiology
https://www.readbyqxmd.com/read/23814126/von-meyenburg-complexes-mimicking-metastatic-disease-at-laparotomy-for-focal-nodular-hyperplasia
#20
Matthanja Bieze, Joanne Verheij, Saffire S Phoa, Thomas M van Gulik
A 44-year-old woman presented with symptoms of fatigue and increasing abdominal discomfort. MRI with the hepatobiliary contrast Gd-EOB-DTPA (Primovist) was performed showing a 6 cm lesion in segment 2/3 of the liver typical for focal nodular hyperplasia (FNH). Because of severe complaints attributed to the lesion, the patient was scheduled for resection. At laparotomy multiple small white lesions were found throughout the liver with enlarged locoregional lymph nodes. Macroscopically, the findings could be consistent with widespread metastases and the surgeon felt compelled to determine the nature of these lesions before continuing resection...
2013: BMJ Case Reports
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