Vasighe Sadat Mirbagheri, Alireza Alishahi, Gholamreza Ahmadian, Seyyed Hamidreza Hashemi Petroudi, Seyed Mahdi Ojagh, Gianfranco Romanazzi
The antibacterial effects of chitosan have been widely studied, but the underlying molecular mechanisms are not fully understood. We investigated the molecular responses of Escherichia coli MG1655 cell, a model gram-negative bacterium, upon exposure to chitosan (Cs), alkylated Cs (AlkCs), and chitosan nanoparticles (CsNPs). Nine target genes involved in relevant signaling pathways (ompF, ompC, ompA, mrcA, mrcB, mgtA, glnA, kdpA, lptA) were selected for analysis. A significant reduction in the expression of mrcA, mgtA, glnA, and lptA genes was observed in the cells treated with Cs...
September 19, 2023: International Journal of Biological Macromolecules