Ying Zhao, Fei Ye, Torkel B Brismar, Xuan Li, Rui He, Rainer Heuchel, Ramy El-Sayed, Neus Feliu, Wenyi Zheng, Sandra Oerther, Joydeep Dutta, Wolfgang J Parak, Mamoun Muhammed, Moustapha Hassan
Late diagnosis and refractory behavior toward current treatment protocols make pancreatic ductal adenocarcinoma (PDAC) one of the most difficult cancer forms to treat. The imaging-based approach plays an important role to identify potentially curable PDAC patients in high-risk groups at the early stage. In the present study, we developed a core-shell structured gold nanorod (AuNR) as a contrast agent for multimodal imaging and investigated its application for PDAC diagnosis. The composite nanoparticles composed of a AuNR core inside a layer of mesoporous silica that was then coated with a gadolinium oxide carbonate shell (AuNR-SiO2 -Gd) are designed to be used in magnetic resonance imaging (MRI), X-ray computed tomography (CT), and photoacoustic imaging (PAI)...
November 17, 2020: ACS Applied Materials & Interfaces