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https://www.readbyqxmd.com/read/27716273/a-clinical-combined-gadobutrol-bolus-and-slow-infusion-protocol-enabling-angiography-inversion-recovery-whole-heart-and-late-gadolinium-enhancement-imaging-in-a-single-study
#1
Animesh Tandon, Lorraine James, Markus Henningsson, René M Botnar, Amanda Potersnak, Gerald F Greil, Tarique Hussain
BACKGROUND: The use of gadolinium contrast agents in cardiovascular magnetic resonance is well-established and serves to improve both vascular imaging as well as enable late gadolinium enhancement (LGE) imaging for tissue characterization. Currently, gadofosveset trisodium, an intravascular contrast agent, combined with a three-dimensional inversion recovery balanced steady state free precession (3D IR bSSFP) sequence, is commonly used in pediatric cardiac imaging and yields excellent vascular imaging, but cannot be used for late gadolinium enhancement...
October 5, 2016: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/27652261/immediate-adverse-reactions-to-gadolinium-based-mr-contrast-media-a-retrospective-analysis-on-10-608-examinations
#2
Vincenza Granata, Marco Cascella, Roberta Fusco, Nicoletta dell'Aprovitola, Orlando Catalano, Salvatore Filice, Vincenzo Schiavone, Francesco Izzo, Arturo Cuomo, Antonella Petrillo
Background and Purpose. Contrast media (CM) for magnetic resonance imaging (MRI) may determine the development of acute adverse reactions. Objective was to retrospectively assess the frequency and severity of adverse reactions associated with gadolinium-based contrast agents (GBCAs) injection in patients who underwent MRI. Material and Methods. At our center 10608 MRI examinations with CM were performed using five different GBCAs: Gd-BOPTA (MultiHance), Gd-DTPA (Magnevist), Gd-EOBDTPA (Primovist), Gd-DOTA (Dotarem), and Gd-BTDO3A (Gadovist)...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27098885/rapid-and-robust-variable-flip-angle-t1-mapping-using-interleaved-two-dimensional-multislice-spoiled-gradient-echo-imaging
#3
Rahel Heule, Oliver Bieri
PURPOSE: Conventional T1 mapping using three-dimensional (3D) radiofrequency (RF) spoiled gradient echo (SPGR) imaging with short repetition times (TR) is adversely affected by incomplete spoiling (i.e. residual T2 dependency). In this work, an optimized interleaved 2D multislice SPGR sequence scheme and an adapted postprocessing procedure are evaluated for highly T2 -insensitive T1 quantification of human brain tissues. METHODS: An efficient 2D multislice SPGR protocol including a relatively long TR of 200 ms is investigated with careful consideration of cross talk and magnetization transfer effects...
April 21, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/26863577/macrocyclic-and-other-non-group-1-gadolinium-contrast-agents-deposit-low-levels-of-gadolinium-in-brain-and-bone-tissue-preliminary-results-from-9-patients-with-normal-renal-function
#4
Nozomu Murata, Luis F Gonzalez-Cuyar, Kiyoko Murata, Corinne Fligner, Russell Dills, Daniel Hippe, Kenneth R Maravilla
OBJECTIVE: The purpose of this study was to determine whether gadolinium (Gd) is deposited in brain and bone tissues in patients receiving only non-Group 1 agents, either macrocyclic or linear protein interacting Gd-based contrast agents, with normal renal function. Group 1 agents are linear agents most associated with nephrogenic systemic fibrosis that the US Federal Drug Administration has defined as contraindicated in patients at risk for this disease. MATERIALS AND METHODS: This study was institutional review board approved and Health Insurance Portability and Accountability Act compliant for retrospective review of records and also had signed autopsy consent authorizing use of decedent's tissue in research studies...
July 2016: Investigative Radiology
https://www.readbyqxmd.com/read/26619282/effect-of-temporal-resolution-on-diagnostic-performance-of-dynamic-contrast-enhanced-magnetic-resonance-imaging-of-the-prostate
#5
Ahmed E Othman, Florian Falkner, Jakob Weiss, Stephan Kruck, Robert Grimm, Petros Martirosian, Konstantin Nikolaou, Mike Notohamiprodjo
OBJECTIVE: The aim of this study was to assess the effect of temporal resolution on semiquantitative and pharmacokinetic parameters from dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and their diagnostic accuracy regarding the detection of potentially malignant prostate lesions. MATERIALS AND METHODS: Sixty consecutive male patients (age, 64.5 ± 7.0 years) with clinically suspected prostate cancer were included. All patients underwent multiparametric MRI of the prostate (T2-weighted, diffusion-weighted imaging, and DCE-MRI) on a 3 T MRI scanner...
May 2016: Investigative Radiology
https://www.readbyqxmd.com/read/26268906/multi-modal-magnetic-resonance-imaging-and-histology-of-vascular-function-in-xenografts-using-macromolecular-contrast-agent-hyperbranched-polyglycerol-hpg-gdf
#6
Jennifer H E Baker, Kelly C McPhee, Firas Moosvi, Katayoun Saatchi, Urs O Häfeli, Andrew I Minchinton, Stefan A Reinsberg
Macromolecular gadolinium (Gd)-based contrast agents are in development as blood pool markers for MRI. HPG-GdF is a 583 kDa hyperbranched polyglycerol doubly tagged with Gd and Alexa 647 nm dye, making it both MR and histologically visible. In this study we examined the location of HPG-GdF in whole-tumor xenograft sections matched to in vivo DCE-MR images of both HPG-GdF and Gadovist. Despite its large size, we have shown that HPG-GdF extravasates from some tumor vessels and accumulates over time, but does not distribute beyond a few cell diameters from vessels...
January 2016: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/26069143/acute-respiratory-distress-syndrome-after-the-use-of-gadolinium-contrast-media
#7
Jihye Park, Il Hwan Byun, Kyung Hee Park, Jae-Hyun Lee, Eun Ji Nam, Jung-Won Park
Acute respiratory distress syndrome (ARDS) is a medical emergency that threatens life. To this day, ARDS is very rarely reported by iodine contrast media, and there is no reported case of ARDS induced by gadolinium contrast media. Here, we present a case with ARDS after the use of gadobutrol (Gadovist) as a magnetic resonance imaging (MRI) contrast medium. A 26 years old female without any medical history, including allergic diseases and without current use of drugs, visited the emergency room for abdominal pain...
July 2015: Yonsei Medical Journal
https://www.readbyqxmd.com/read/25670214/characterisation-and-application-of-ultra-high-spin-clusters-as-magnetic-resonance-relaxation-agents
#8
Gisela Guthausen, Julyana R Machado, Burkhard Luy, Amer Baniodeh, Annie K Powell, Steffen Krämer, Florian Ranzinger, Maria P Herrling, Susanne Lackner, Harald Horn
In Magnetic Resonance Tomography (MRT) image contrast can be improved by adding paramagnetic relaxation agents such as lanthanide ions. Here we report on the use of highly paramagnetic isostructural Fe(III)/4f coordination clusters with a [Fe10Ln10] core to enhance relaxation. Measurements were performed over the range of (1)H Larmor frequencies of 10 MHz to 1.4 GHz in order to determine the relevant parameters for longitudinal and transverse relaxivities. Variation of the lanthanide ion allows differentiation of relaxation contributions from electronic states and molecular dynamics...
March 21, 2015: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/25638228/single-bolus-versus-split-dose-gadolinium-administration-in-extra-cellular-volume-calculation-at-3-tesla
#9
Adam K McDiarmid, Peter P Swoboda, Bara Erhayiem, David P Ripley, Ananth Kidambi, David A Broadbent, David M Higgins, John P Greenwood, Sven Plein
BACKGROUND: Diffuse myocardial fibrosis may be quantified with cardiovascular magnetic resonance (CMR) by calculating extra-cellular volume (ECV) from native and post-contrast T1 values. Accurate ECV calculation is dependent upon the contrast agent having reached equilibrium within tissue compartments. Previous studies have used infusion or single bolus injections of contrast to calculate ECV. In clinical practice however, split dose contrast injection is commonly used as part of stress/rest perfusion studies...
2015: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/25154504/gadolinium-detection-via-in-vivo-prompt-gamma-neutron-activation-analysis-following-gadolinium-based-contrast-agent-injection-a-pilot-study-in-10-human-participants
#10
J L Gräfe, F E McNeill, M D Noseworthy, D R Chettle
Gadolinium (Gd) based contrast agents are routinely used as part of many magnetic resonance imaging (MRI) procedures. The widespread use of these agents and concerns about Gd toxicity, motivated us to develop a monitoring procedure that could non-invasively measure quantitatively potential retention of toxic free Gd in tissues after use of the agent. We have been developing a method to measure Gd painlessly and non-invasively by prompt gamma neutron activation analysis. In this paper we present the results of a pilot study where we show that we can measure Gd, quantitatively in vivo, in the lower leg muscle of 10 participants...
September 2014: Physiological Measurement
https://www.readbyqxmd.com/read/24688815/neurotoxic-effects-of-indocyanine-green-cerebellar-granule-cell-culture-viability-study
#11
Beata Toczylowska, Elzbieta Zieminska, Grazyna Goch, Daniel Milej, Anna Gerega, Adam Liebert
The aim of this study was to examine neurotoxicity indocyanine green (ICG). We assessed viability of primary cerebellar granule cell culture (CGC) exposed to ICG to test two mechanisms that could be the first triggers causing neuronal toxicity: imbalance in calcium homeostasis and the degree of oligomerization of ICG molecules. We have observed this imbalance in CGC after exposure to 75-125μΜ ICG and dose and application sequence dependent protective effect of Gadovist on surviving neurons in vitro when used with ICG...
March 1, 2014: Biomedical Optics Express
https://www.readbyqxmd.com/read/24365398/interference-of-gadolinium-based-contrast-agents-on-colorimetric-calcium-assays
#12
Ronald Yan, Heather Tarr, Martin McNally, Louis-Jacques Cartier, Yu Chen
OBJECTIVE: The aim of this study was to evaluate the potential interference of five gadolinium-based contrast agents (GBCAs), gadodiamide (Omniscan®), gadobenate dimeglumine (Multihance®), gadoxetate disodium (Primovist®), gadobutrol (Gadovist®), and gadoteridol (Prohance®), on three clinical laboratory widely used colorimetric calcium assays including the newly developed 5-nitro-5'methyl-l,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (NM-BAPTA) method. METHODS: Plasma was collected from healthy volunteers aged 23-52, and spiked with varying concentrations of the five GBCAs...
May 2014: Clinical Biochemistry
https://www.readbyqxmd.com/read/24250860/the-relationship-between-enhanced-plaques-with-gadovist-and-magnevist-contrast-brain-magnetic-resonance-imaging-and-the-neurological-deficit-in-the-acute-phase-of-relapsing-remitting-multiple-sclerosis
#13
Mahboobeh Yaghoobi, Mohammad Hossein Harirchian, Kavous Firouznia, Somayeh Behzadi, Hassan Hashemi, Hossein Ghanaati, Madjid Shakiba, Amir Hossein Jalali, Shahrzad Mohebbi
BACKGROUND: Magnetic resonance imaging (MRI) is the standard method for observing brain plaques and contrast material injection is necessary for demonstrating the active plaque.This study compared the rate of enhancement of plaques with Gadovist and Magnevist in relapse phase of MS. METHODS: In this double blind study, after neurological examination of 62 patients in the attack phase of MS, two consecutive MRIs were performed with Gadovist and Magnevist with 48 hours interval...
2012: Iranian Journal of Neurology
https://www.readbyqxmd.com/read/23435930/gadobutrol-a-review-of-its-use-for-contrast-enhanced-magnetic-resonance-imaging-in-adults-and-children
#14
REVIEW
Lesley J Scott
Since the introduction of the first gadolinium-based contrast agent (GBCA) approximately 25 years ago, magnetic resonance imaging (MRI) using GBCAs has revolutionized diagnostic and follow-up imaging of pathological lesions, with clinical applications expanded to encompass almost all fields of medicine. Intravenous gadobutrol (Gadovist™ [EU]; Gadavist(®) [USA]) is a second-generation extracellular non-ionic macrocyclic GBCA that is used in patients undergoing diagnostic contrast-enhanced MRI for visualization of pathological lesions in the CNS and all other body regions or for contrast-enhanced magnetic resonance angiography (MRA) to evaluate perfusion and flow-related abnormalities...
April 2013: Clinical Drug Investigation
https://www.readbyqxmd.com/read/23296304/speciation-of-gadolinium-in-surface-water-samples-and-plants-by-hydrophilic-interaction-chromatography-hyphenated-with-inductively-coupled-plasma-mass-spectrometry
#15
Uwe Lindner, Jana Lingott, Silke Richter, Norbert Jakubowski, Ulrich Panne
Hydrophilic interaction chromatography (HILIC) coupled with inductively coupled plasma mass spectrometry (ICP-MS) was optimized for speciation analysis of gadolinium-based contrast agents in environmental samples, in particular surface river waters and plants. Surface water samples from the Teltow channel, near Berlin, were investigated over a distance of 5 km downstream from the influx of a wastewater treatment plant. The total concentration of gadolinium increased significantly from 50 to 990 ng L(-1) due to the influx of the contrast agents...
February 2013: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/23281283/gadolinium-containing-magnetic-resonance-contrast-media-investigation-on-the-possible-transchelation-of-gd%C3%A2-%C3%A2-%C2%BA-to-the-glycosaminoglycan-heparin
#16
Matthias Taupitz, Nicola Stolzenburg, Monika Ebert, Jörg Schnorr, Ralf Hauptmann, Harald Kratz, Bernd Hamm, Susanne Wagner
Retention of gadolinium (Gd) in biological tissues is considered an important cofactor in the development of nephrogenic systemic fibrosis (NSF). Research on this issue has so far focused on the stability of Gd-based contrast media (GdCM) and a possible release of Gd³⁺ from the complex. No studies have investigated competing chelators that may occur in vivo. We performed proton T(1) -relaxometry in solutions of nine approved GdCM and the macromolecular chelator heparin (250 000 IU per 10 ml) without and with addition of ZnCl₂...
March 2013: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/23011188/toxicological-safety-evaluation-of-gadobutrol
#17
Christiane Wack, Thomas Steger-Hartmann, Louis Mylecraine, Rainer Hofmeister
OBJECTIVES: Gadobutrol (Gadovist/Gadavist, Bayer Pharma AG, Berlin, Germany) is a nonionic, macrocyclic, gadolinium-based contrast agent for magnetic resonance imaging of the central nervous system as well as liver and kidneys and for contrast enhancement in magnetic resonance angiography. For risk assessment of the single diagnostic use in humans, the toxicity of this compound was evaluated with a series of preclinical studies. MATERIALS AND METHODS: Preclinical studies into acute, repeated-dose, reproductive, and developmental toxicity as well as genotoxicity, local tolerance, contact-sensitizing potential, and antigenicity were performed...
November 2012: Investigative Radiology
https://www.readbyqxmd.com/read/22890801/effect-of-mr-contrast-agents-on-quantitative-accuracy-of-pet-in-combined-whole-body-pet-mr-imaging
#18
Cristina Lois, Ilja Bezrukov, Holger Schmidt, Nina Schwenzer, Matthias K Werner, Jürgen Kupferschläger, Thomas Beyer
PURPOSE: Clinical PET/MR acquisition protocols entail the use of MR contrast agents (MRCA) that could potentially affect PET quantification following MR-based attenuation correction (AC). We assessed the effect of oral and intravenous (IV) MRCA on PET quantification in PET/MR imaging. METHODS: We employed two MRCA: Lumirem (oral) and Gadovist (IV). First, we determined their reference PET attenuation values using a PET transmission scan (ECAT-EXACT HR+, Siemens) and a CT scan (PET/CT Biograph 16 HI-REZ, Siemens)...
November 2012: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/22790331/23na-chemical-shift-imaging-and-gd-enhancement-of-myocardial-edema
#19
COMPARATIVE STUDY
Eissa N E Aguor, Cees W A van de Kolk, Fatih Arslan, Marcel G J Nederhoff, Pieter A F M Doevendans, Gerard Pasterkamp, Gustav J Strijkers, Cees J A van Echteld
Myocardial edema can arise in several disease states. MRI contrast agent can accumulate in edematous tissue, which complicates differential diagnosis with contrast-enhanced (CE)-MRI and might lead to overestimation of infarct size. Sodium Chemical Shift Imaging ((23)Na-CSI) may provide an alternative for edema imaging. We have developed a non-infarct, isolated rat heart model with two levels of edema, which was studied with (23)Na-CSI and CE-MRI. In edematous, but viable tissue the extracellular sodium (Na (e) (+)) signal is hypothesized to increase, but not the intracellular sodium (Na (i) (+)) signal...
February 2013: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/22766975/detection-and-treatment-of-spinal-csf-leaks-in-idiopathic-intracranial-hypotension
#20
G Albes, H Weng, D Horvath, C Musahl, H Bäzner, H Henkes
INTRODUCTION: This study aimed to evaluate the diagnostic imaging findings and treatment results of patients with idiopathic intracranial hypotension (IIH) due to cerebrospinal fluid (CSF) leaks. METHODS: Between February 2009 and April 2012, 26 IIH patients (15 men, median age 49 years) presenting with orthostatic headache (n = 20) and/or with spontaneous subdural effusions or subarachnoid hemorrhage (n = 19) were enrolled. Twenty-three patients underwent a whole spine CT and MRI myelography, starting 45 min after the intrathecal injection of 9 cc of iomeprol (Imeron 300 M) and 1 cc of gadobutrolum (Gadovist)...
December 2012: Neuroradiology
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