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gadobutrol

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https://www.readbyqxmd.com/read/28640692/comparison-of-gadolinium-concentrations-within-multiple-rat-organs-after-intravenous-administration-of-linear-versus-macrocyclic-gadolinium-chelates
#1
Robert J McDonald, Jennifer S McDonald, Daying Dai, Dana Schroeder, Mark E Jentoft, David L Murray, Ramanathan Kadirvel, Laurence J Eckel, David F Kallmes
Purpose To compare gadolinium tissue concentrations of multiple linear and macrocyclic chelates in a rat model to better understand the scope and extent of tissue deposition following multiple intravenous doses of gadolinium-based contrast agent (GBCA). Materials and Methods In this Institutional Animal Care and Use Committee-approved study, healthy rats received 20 intravenous injections of 2.5 mmol gadolinium per kilogram (gadolinium-exposed group) or saline (control group) over a 26-day period. Unenhanced T1 signal intensities of the dentate nucleus were measured from magnetic resonance (MR) images obtained prior to GBCA injection and 3 days after final injection...
June 19, 2017: Radiology
https://www.readbyqxmd.com/read/28619842/cumulative-dose-of-macrocyclic-gadolinium-based-contrast-agent-improves-detection-of-enhancing-lesions-in-patients-with-multiple-sclerosis
#2
A Rovira, C Auger, E Huerga, J F Corral, R Mitjana, J Sastre-Garriga, M Tintoré, X Montalban
BACKGROUND AND PURPOSE: Gadolinium-enhanced MR imaging is currently the reference standard for detecting active inflammatory lesions in patients with multiple sclerosis. The sensitivity of MR imaging for this purpose may vary according to the physicochemical characteristics of the contrast agent used and the acquisition strategy. The purpose of this study was to compare detection of gadolinium- enhancing lesions or active disease following a single or cumulative dose of a macrocyclic gadolinium-based contrast agent with different image acquisition delays in patients with clinically isolated syndrome or relapsing multiple sclerosis...
June 15, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28594113/self-gated-4d-mri-of-the-liver-initial-clinical-results-of-continuous-multiphase-imaging-of-hepatic-enhancement
#3
Jakob Weiss, Mike Notohamiprodjo, Petros Martirosian, Jana Taron, Marcel D Nickel, Manuel Kolb, Fabian Bamberg, Konstantin Nikolaou, Ahmed E Othman
PURPOSE: To evaluate the feasibility of a self-gated free-breathing volume-interpolated breath-hold examination (VIBE) sequence using compressed sensing (CS) for contrast-enhanced multiphase liver MRI. MATERIALS AND METHODS: We identified 23 patients who underwent multiphase gadobutrol-enhanced liver magnetic resonance imaging (MRI) using 1) a prototype free-breathing VIBE sequence with respiratory self-gating and CS (VIBECS ), and 2) a standard breath-hold VIBE (VIBESTD ) on the same 1...
June 8, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28586445/relative-conspicuity-of-gadolinium-based-contrast-agents-in-interventional-pain-procedures
#4
Timothy P Maus, Beth A Schueler, Dixon J Magnuson, Dayne Magnuson
Objective. : To assess the relative radiographic conspicuity of gadolinium-based contrast agents (GBCAs) that may be used in spinal injection procedures when iodine-based contrast agents are contraindicated. Methods. : Eight GBCAs and three iodinated agents of varying iodine concentrations were radiographed under conditions representative of lumbar spinal injections at four kilovoltage peak (kVp) values. Radiographic contrast of each agent was measured as the percent pixel value difference with respect to background...
April 1, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28579796/the-impact-of-injector-based-contrast-agent-administration-on-bolus-shape-and-magnetic-resonance-angiography-image-quality
#5
Gregor Jost, Jan Endrikat, Hubertus Pietsch
OBJECTIVE: To compare injector-based contrast agent (CA) administration with hand injection in magnetic resonance angiography (MRA). METHODS: Gadobutrol was administered in 6 minipigs with 3 protocols: (a) hand injection (one senior technician), (b) hand injection (6 less-experienced technicians), and (c) power injector administration. The arterial bolus shape was quantified by test bolus measurements. A head and neck MRA was performed for quantitative and qualitative comparison of signal enhancement...
2017: Magnetic Resonance Insights
https://www.readbyqxmd.com/read/28574637/efficacy-and-safety-of-gadobutrol-enhanced-mra-of-the-renal-arteries-results-from-grams-gadobutrol-enhanced-renal-artery-mra-study-a-prospective-intraindividual-multicenter-phase-3-blinded-study
#6
Kelly E Fabrega-Foster, Sheela Agarwal, Neda Rastegar, Daniel Haverstock, Jacob M Agris, Ihab R Kamel
PURPOSE: To compare the performance of magnetic resonance angiography (MRA) with 1M gadobutrol, a high relaxivity macrocyclic contrast agent, to 2D time-of-flight MRA (ToF-MRA) using computed tomographic angiography (CTA) as the standard of reference. Primary objectives were evaluation for superiority of structural delineation and noninferiority for detection and exclusion of clinically significant disease. MATERIALS AND METHODS: In all, 315 subjects underwent unenhanced and contrast-enhanced MRA with 1M gadobutrol (CE-MRA) and were scanned with 1...
June 2, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28570419/ultra-high-field-9-4-t-mri-analysis-of-contrast-agent-transport-across-the-blood-perilymph-barrier-and-intrastrial-fluid-blood-barrier-in-the-mouse-inner-ear
#7
S Allen Counter, Sahar Nikkhou-Aski, Peter Damberg, Cecilia Engmér Berglin, Göran Laurell
HYPOTHESIS: Effective paramagnetic contrast agent for the penetration of the perilymphatic spaces of the scala tympani, scala vestibuli, and scala media of the mouse inner ear can be determined using intravenous injection of various gadolinium (Gd) complexes and ultra-high-field magnetic resonance imaging (MRI) at 9.4 Tesla. BACKGROUND: A number of contrast agents have been explored in experimental high-field MRI to determine the most effective Gd complex for ideal signal-to-noise ratio and maximal visualization of the in vivo mammalian inner ear in analyzing the temporal and spatial parameters involved in drug penetration of the blood-perilymph barrier and intrastrial fluid-blood barrier in the mouse model using MRI...
May 31, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28489466/intrathecal-injection-of-gadobutrol-a-tale-of-caution
#8
Corey Reeves, Enrique Galang, Raj Padalia, Nam Tran, Devang Padalia
In the field of interventional pain medicine a radiocontrast agent is commonly used in conjunction with fluoroscopy. Limited work has been published regarding the use of gadolium based contrast agents (GBCA) in the intrathecal space. We report a case of an intrathecal gadobutrol injection resulting in neurotoxic manifestations.A 60-year-old female with a history significant for lumbar post-laminectomy syndrome and intrathecal drug delivery implantation was admitted for lumbar fusion and kyphoplasty. Postoperatively, the patient had escalating pain medication requirements...
June 2017: Journal of Pain & Palliative Care Pharmacotherapy
https://www.readbyqxmd.com/read/28473338/appropriate-minimal-dose-of-gadobutrol-for-3d-time-resolved-mra-of-the-supra-aortic-arteries-comparison-with-conventional-single-phase-high-resolution-3d-contrast-enhanced-mra
#9
S H Bak, H G Roh, W-J Moon, J W Choi, H S An
BACKGROUND AND PURPOSE: The development of nephrogenic systemic fibrosis and neural tissue deposition is gadolinium dose-dependent. The purpose of this study was to determine the appropriate minimal dose of gadobutrol with time-resolved MRA to assess supra-aortic arterial stenosis with contrast-enhanced MRA as a reference standard. MATERIALS AND METHODS: Four hundred sixty-two consecutive patients underwent both standard-dose contrast-enhanced MRA and low-dose time-resolved MRA and were classified into 3 groups; group A (a constant dose of 1 mL for time-resolved MRA), group B (2 mL), or group C (3 mL)...
May 4, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28455632/utility-of-stress-perfusion-cardiac-magnetic-resonance-in-follow-up-of-patients-undergoing-percutaneous-coronary-interventions-of-the-left-main-coronary-artery
#10
Samuele Nanni, Luigi Lovato, Gabriele Ghetti, Fabio Vagnarelli, GianGaspare Mineo, Rossella Fattori, Francesco Saia, Antonio Marzocchi, Cinzia Marrozzini, Maurizio Zompatori, Letizia Bacchi Reggiani, Franco Semprini, Giovanni Melandri, Elena Biagini, Anna Corsini, Giulia Norscini, Claudio Rapezzi
To assess the accuracy of cardiac magnetic resonance (CMR) for the diagnosis of angiographic stenosis after percutaneous coronary intervention (PCI) of left main coronary artery (LMCA). Patients undergone in the last year PCI of unprotected LMCA and scheduled for conventional X-ray coronary angiography (CXA) were evaluated with stress perfusion CMR within 2 weeks before CXA. Main contraindications to CMR were exclusion criteria. Stress perfusion CMR was performed to follow a bolus of contrast Gadobutrol after 3 min of adenosine infusion...
April 28, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28448310/comparison-of-power-versus-manual-injection-in-bolus-shape-and-image-quality-on-contrast-enhanced-magnetic-resonance-angiography-an-experimental-study-in-a-swine-model
#11
Takahiro Tsuboyama, Gregor Jost, Hubertus Pietsch, Noriyuki Tomiyama
OBJECTIVE: The aim of this study was to compare power versus manual injection in bolus shape and image quality on contrast-enhanced magnetic resonance angiography (CE-MRA). MATERIALS AND METHODS: Three types of CE-MRA (head-neck 3-dimensional [3D] MRA with a test-bolus technique, thoracic-abdominal 3D MRA with a bolus-tracking technique, and thoracic-abdominal time-resolved 4-dimensional [4D] MRA) were performed after power and manual injection of gadobutrol (0...
April 26, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28429574/flip-angle-optimization-for-balanced-ssfp-cardiac-cine-imaging-following-the-application-of-standard-extracellular-contrast-agent-gadobutrol
#12
Daniel L R Kuetting, Darius Dabir, Julian Luetkens, Andreas Feisst, Rami Homsi, Daniel Thomas, Hans H Schild, Alois M Sprinkart
PURPOSE: To investigate the effect of the flip angle (FA) on the blood-myocardium contrast and to define the FA leading to highest image quality in contrast-enhanced balanced steady-state free precession (bSSFP) images. bSSFP images provide excellent contrast between myocardium and blood with high signal-to-noise and contrast-to-noise ratios (SNR, CNR). In clinical practice, bSSFP images are typically acquired following the injection of extracellular contrast agents (ECAs), although ECAs decrease the blood-myocardium contrast...
April 21, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28425048/biopsy-targeting-with-dynamic-contrast-enhanced-versus-standard-neuronavigation-mri-in-glioma-a-prospective-double-blinded-evaluation-of-selection-benefits
#13
Vera C Keil, Bogdan Pintea, Gerrit H Gielen, Susanne Greschus, Rolf Fimmers, Jürgen Gieseke, Matthias Simon, Hans H Schild, Dariusch R Hadizadeh
Current biopsy planning based on contrast-enhanced T1W (CET1W) or FLAIR sequences frequently delivers biopsy samples that are not in concordance with the gross tumor diagnosis. This study investigates whether the quantitative information of transfer constant K(trans) maps derived from T1W dynamic contrast-enhanced MRI (DCE-MRI) can help enhance the quality of biopsy target selection in glioma. 28 patients with suspected glioma received MRI including DCE-MRI and a standard neuronavigation protocol of 3D FLAIR- and CET1W data sets (0...
April 19, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28412420/stress-perfusion-cmr-in-patients-with-known-and-suspected-cad-prognostic-value-and-optimal-ischemic-threshold-for-revascularization
#14
Gabriella Vincenti, Pier Giorgio Masci, Pierre Monney, Tobias Rutz, Sarah Hugelshofer, Mirdita Gaxherri, Olivier Muller, Juan F Iglesias, Eric Eeckhout, Valentina Lorenzoni, Cyril Pellaton, Christophe Sierro, Juerg Schwitter
OBJECTIVES: This study sought to determine the ischemia threshold and additional prognostic factors that identify patients for safe deferral from revascularizations in a large cohort of all-comer patients with known or suspected coronary artery disease (CAD). BACKGROUND: Stress-perfusion cardiac magnetic resonance (CMR) is increasingly used in daily practice for ischemia detection. However, there is insufficient evidence about the ischemia burden that identifies patients who benefit from revascularization versus those with a good prognosis who receive drugs only...
May 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28367903/longitudinal-assessment-of-dentate-nuclei-relaxometry-during-massive-gadobutrol-exposure
#15
Enrico Tedeschi, Sirio Cocozza, Pasquale Borrelli, Lorenzo Ugga, Vincenzo Brescia Morra, Giuseppe Palma
We report the assessment of Dentate Nuclei (DN) R1 (1/T1) and R2* (1/R2*) values in a patient with relapsing-remitting Multiple Sclerosis, exposed to 22 standard (0.1 mmol/kg) doses of gadobutrol, who underwent eight relaxometric magnetic resonance (MR) measurements within two years. DN R1 did not significantly increase nor correlated with cumulative gadobutrol administration, even after a total dose of 130 ml. Likewise, DN R2* relaxometry remained unchanged. In conclusion, massive gadobutrol exposure did not induce significant DN relaxometry changes...
March 27, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/28364045/diagnostic-accuracy-of-3-0-t-magnetic-resonance-t1-and-t2-mapping-and-t2-weighted-dark-blood-imaging-for-the-infarct-related-coronary-artery-in-non-st-segment-elevation-myocardial-infarction
#16
Jamie Layland, Samuli Rauhalammi, Matthew M Y Lee, Nadeem Ahmed, Jaclyn Carberry, Vannesa Teng Yue May, Stuart Watkins, Christie McComb, Kenneth Mangion, John D McClure, David Carrick, Anna O'Donnell, Arvind Sood, Margaret McEntegart, Keith G Oldroyd, Aleksandra Radjenovic, Colin Berry
BACKGROUND: Patients with recent non-ST-segment elevation myocardial infarction commonly have heterogeneous characteristics that may be challenging to assess clinically. METHODS AND RESULTS: We prospectively studied the diagnostic accuracy of 2 novel (T1, T2 mapping) and 1 established (T2-weighted short tau inversion recovery [T2W-STIR]) magnetic resonance imaging methods for imaging the ischemic area at risk and myocardial salvage in 73 patients with non-ST-segment elevation myocardial infarction (mean age 57±10 years, 78% male) at 3...
March 31, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28323657/histology-and-gadolinium-distribution-in-the-rodent-brain-after-the-administration-of-cumulative-high-doses-of-linear-and-macrocyclic-gadolinium-based-contrast-agents
#17
Jessica Lohrke, Anna-Lena Frisk, Thomas Frenzel, Laura Schöckel, Martin Rosenbruch, Gregor Jost, Diana Constanze Lenhard, Martin A Sieber, Volker Nischwitz, Astrid Küppers, Hubertus Pietsch
OBJECTIVES: Retrospective studies in patients with primary brain tumors or other central nervous system pathologies as well as postmortem studies have suggested that gadolinium (Gd) deposition occurs in the dentate nucleus (DN) and globus pallidus (GP) after multiple administrations of primarily linear Gd-based contrast agents (GBCAs). However, this deposition has not been associated with any adverse effects or histopathological alterations. The aim of this preclinical study was to systematically examine differences between linear and macrocyclic GBCAs in their potential to induce changes in brain and skin histology including Gd distribution in high spatial resolution...
June 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28289991/quantitative-analysis-of-late-gadolinium-enhancement-in-hypertrophic-cardiomyopathy-comparison-of-diagnostic-performance-in-myocardial-fibrosis-between-gadobutrol-and-gadopentetate-dimeglumine
#18
Dongting Liu, Xiaohai Ma, Jiayi Liu, Lei Zhao, Hui Chen, Lei Xu, Zhonghua Sun, Zhanming Fan
The purpose of this study was to compare different semi-automated late gadolinium enhancement (LGE) quantification techniques using gadobutrol and gadopentetate dimeglumine contrast agents with regard to the diagnosis of fibrotic myocardium in patients with hypertrophic cardiomyopathy (HCM). Thirty patients with HCM underwent two cardiac MRI protocols with use of gadobutrol and gadopentetate dimeglumine. Contrast-to-noise ratio (CNR) between LGE area and remote myocardium (CNRremote), between LGE area and left ventricular blood pool (CNRpool), and signal-to-noise ratio (SNR) in LGE were compared...
March 13, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28289935/repeated-intravenous-administration-of-gadobutrol-does-not-lead-to-increased-signal-intensity-on-unenhanced-t1-weighted-images-a-voxel-based-whole-brain-analysis
#19
Soenke Langner, Marie-Luise Kromrey, Jens-Peter Kuehn, Matthias Grothe, Martin Domin
OBJECTIVES: To identify a possible association between repeated intravenous administration of gadobutrol and increased signal intensity in the grey and white matter using voxel-based whole-brain analysis. METHODS: In this retrospective single-centre study, 217 patients with a clinically isolated syndrome underwent baseline brain magnetic resonance imaging and at least one annual follow-up examination with intravenous administration of 0.1 mmol/kg body weight of gadobutrol...
March 13, 2017: European Radiology
https://www.readbyqxmd.com/read/28279370/myocardial-infarct-size-by-cmr-in-clinical%C3%A2-cardioprotection-studies-insights-from-randomized-controlled-trials
#20
Heerajnarain Bulluck, Matthew Hammond-Haley, Shane Weinmann, Roberto Martinez-Macias, Derek J Hausenloy
OBJECTIVES: The aim of this study was to review randomized controlled trials (RCTs) using cardiac magnetic resonance (CMR) to assess myocardial infarct (MI) size in reperfused patients with ST-segment elevation myocardial infarction (STEMI). BACKGROUND: There is limited guidance on the use of CMR in clinical cardioprotection RCTs in patients with STEMI treated by primary percutaneous coronary intervention. METHODS: All RCTs in which CMR was used to quantify MI size in patients with STEMI treated with primary percutaneous coronary intervention were identified and reviewed...
March 2017: JACC. Cardiovascular Imaging
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