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https://www.readbyqxmd.com/read/29319556/gadolinium-accumulation-in-the-deep-cerebellar-nuclei-and-globus-pallidus-after-exposure-to-linear-but-not-macrocyclic-gadolinium-based-contrast-agents-in-a-retrospective-pig-study-with-high-similarity-to-clinical-conditions
#1
Janina Boyken, Thomas Frenzel, Jessica Lohrke, Gregor Jost, Hubertus Pietsch
OBJECTIVE: The aim of this retrospective study was to determine the gadolinium (Gd) concentration in different brain areas in a pig cohort that received repeated administration of Gd-based contrast agents (GBCAs) at standard doses over several years, comparable with a clinical setting. MATERIAL AND METHODS: Brain tissue was collected from 13 Göttingen mini pigs that had received repeated intravenous injections of gadopentetate dimeglumine (Gd-DTPA; Magnevist) and/or gadobutrol (Gadovist)...
January 9, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29306049/evaluation-of-lymphedema-in-upper-extremities-by-mr-lymphangiography-comparison-with-lymphoscintigraphy
#2
Jae Seok Bae, Roh-Eul Yoo, Seung Hong Choi, Seong Oh Park, Hak Chang, Minseok Suh, Gi Jeong Cheon
PURPOSE: To validate usefulness of magnetic resonance (MR) lymphangiography for evaluation of peripheral lymphedema in upper extremities by comparison with lymphoscintigraphy. MATERIALS AND METHODS: This prospective study had institutional review board approval and written informed consent was obtained from all patients. Initially, protocol of MR lymphangiography for upper extremity was established in seven healthy volunteers with 3.0T fat-saturated three-dimensional gradient-echo MR after gadobutrol injection...
January 3, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29275054/gadobutrol-and-the-end-of-the-tap-test
#3
Leonardo C Welling, Mariana S Welling, Eberval G Figueiredo
No abstract text is available yet for this article.
December 21, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29247585/simultaneous-acquisition-of-mr-angiography-and-diagnostic-images-of-abdomen-at-view-sharing-multiarterial-phases-and-comparing-the-effect-of-two-different-contrast-agents
#4
Yoshifumi Noda, Satoshi Goshima, Tomohiro Namimoto, Norihiro Shinkawa, Masataka Nakagawa, Kimihiro Kajita, Hiroshi Kawada, Nobuyuki Kawai, Yukichi Tanahashi, Masayuki Matsuo, Kyongtae T Bae, Toshinori Hirai, Yasuyuki Yamashita
BACKGROUND: Simultaneous acquisition of magnetic resonance angiography (MRA) and diagnostic images is challenging in contrast-enhanced upper abdominal MRI. PURPOSE: To evaluate the image quality of MRA of the abdomen acquired simultaneously with diagnostic MR images, and to compare the contrast effect, conspicuity of aortic branches, and pancreatic lesions in MRA between gadobutrol and gadoterate meglumine. STUDY TYPE: Prospective. POPULATION: Eighty-eight patients with known and suspected upper abdominal disease...
December 16, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29218620/the-impact-of-injector-based-contrast-agent-administration-in-time-resolved-mra
#5
Johannes Budjan, Ulrike I Attenberger, Stefan O Schoenberg, Hubertus Pietsch, Gregor Jost
OBJECTIVES: Time-resolved contrast-enhanced MR angiography (4D-MRA), which allows the simultaneous visualization of the vasculature and blood-flow dynamics, is widely used in clinical routine. In this study, the impact of two different contrast agent injection methods on 4D-MRA was examined in a controlled, standardized setting in an animal model. METHODS: Six anesthetized Goettingen minipigs underwent two identical 4D-MRA examinations at 1.5 T in a single session...
December 7, 2017: European Radiology
https://www.readbyqxmd.com/read/29217300/dynamic-magnetic-resonance-imaging-of-the-breast-comparison-of-gadobutrol-vs-gd-dtpa
#6
F Escribano, M Sentís, J C Oliva, L Tortajada, M Villajos, A Martín, S Ganau
OBJECTIVE: To compare the pharmacokinetic profile of gadobutrol versus Gd-DTPA in dynamic contrast-enhanced MRI (DCE-MRI) in patients with breast cancer. Secondary objectives included comparing the safety profiles and diagnostic efficacy of the two contrast agents for detecting additional malignant lesions. MATERIAL AND METHODS: This retrospective observational study included 400 patients with histologically confirmed breast cancer; 200 underwent DCE-MRI with Gd-DTPA (Magnevist®) and 200 underwent DCE-MRI with gadobutrol (Gadovist®)...
December 4, 2017: Radiología
https://www.readbyqxmd.com/read/29110679/high-throughput-gadobutrol-enhanced-cmr-a-time-and-dose-optimization-study
#7
Tommaso D'Angelo, Chrysanthos Grigoratos, Silvio Mazziotti, Konstantinos Bratis, Faraz Pathan, Alfredo Blandino, Elen Elen, Valentina O Puntmann, Eike Nagel
BACKGROUND: Reducing time and contrast agent doses are important goals to provide cost-efficient cardiovascular magnetic resonance (CMR) imaging. Limited information is available regarding the feasibility of evaluating left ventricular (LV) function after gadobutrol injection as well as defining the lowest dose for high quality scar imaging. We sought to evaluate both aspects separately and systematically to provide an optimized protocol for contrast-enhanced CMR (CE-CMR) using gadobutrol...
November 6, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29097921/investigating-the-lymphatic-system-by-dual-color-elemental-mass-spectrometry-imaging
#8
Ann-Christin Niehoff, Tim Klasen, Rebecca Schmidt, Daniel Palmes, Cornelius Faber, Uwe Karst, Rebecca Hadrian
Secondary lymphedema accompanied with strong restrictions in quality of life is still major side effects in cancer therapy. Therefore, dedicated diagnostic tools and further investigation of the lymphatic system are crucial to improve lymphedema therapy. In this pilot study, a method for quantitative analysis of the lymphatic system in a rat model by laser ablation (LA) with inductively coupled plasma mass spectrometry imaging (ICP-MSI) is presented. As a possible lymph marker, thulium(III)(1R,4R,7R,10R)-α,α',α'',α'''-tetramethyl-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (Tm-DOTMA) is introduced and compared to the clinically used magnetic resonance imaging contrast agent gadolinium(III)2,2',2''-(10-((2R,3S)-1,3,4-trihydroxybutan-2-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate (Gd-DO3A-butrol)...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29097910/analytical-interference-by-contrast-agents-in-biochemical-assays
#9
Sigrid Otnes, Niels Fogh-Andersen, Janne Rømsing, Henrik S Thomsen
Objective: To provide a clinically relevant overview of the analytical interference by contrast agents (CA) in laboratory blood test measurements. Materials and Methods: The effects of five CAs, gadobutrol, gadoterate meglumine, gadoxetate disodium, iodixanol, and iomeprol, were studied on the 29 most frequently performed biochemical assays. One-day-old plasma, serum, and whole blood were spiked with doses of each agent such that the gadolinium agents and the iodine agents reached concentrations of 0...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29091750/t1-shortening-in-the-globus-pallidus-after-multiple-administrations-of-gadobutrol-assessment-with-a-multidynamic-multiecho-sequence
#10
Koung Mi Kang, Seung Hong Choi, Moonjung Hwang, Tae Jin Yun, Ji-Hoon Kim, Chul-Ho Sohn
Purpose To determine the association between the administration of the macrocyclic contrast medium gadobutrol and T1 relaxation time in the brains of patients with normal renal function by using multidynamic multiecho (MDME) magnetic resonance (MR) imaging sequences. Materials and Methods The institutional review board approved this retrospective study, and the need to obtain written informed consent was waived. This study included 46 patients (revealed by an electronic medical record search) who had received one or more gadobutrol injections and a maximum of one MR imaging contrast medium injection other than gadobutrol before MDME sequence acquisition...
November 1, 2017: Radiology
https://www.readbyqxmd.com/read/29023687/a-guide-for-effective-anatomical-vascularization-studies-useful-ex%C3%A2-vivo-methods-for-both-ct-and-mri-imaging-before-dissection
#11
Yohann Renard, Gabriela Hossu, Bailiang Chen, Marine Krebs, Marc Labrousse, Manuela Perez
The objective of this study was to develop a simple and useful injection protocol for imaging cadaveric vascularization and dissection. Mixtures of contrast agent and cast product should provide adequate contrast for two types of ex vivo imaging (MRI and CT) and should harden to allow gross dissection of the injected structures. We tested the most popular contrast agents and cast products, and selected the optimal mixture composition based on their availability and ease of use. All mixtures were first tested in vitro to adjust dilution parameters of each contrast agent and to fine-tune MR imaging acquisition sequences...
October 11, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28976476/comparison-of-unenhanced-t1-weighted-signal-intensities-within-the-dentate-nucleus-and-the-globus-pallidus-after-serial-applications-of-gadopentetate-dimeglumine-versus-gadobutrol-in-a-pediatric-population
#12
Diane M Renz, Stefanie Kümpel, Joachim Böttcher, Alexander Pfeil, Florian Streitparth, Matthias Waginger, Jürgen R Reichenbach, Ulf K Teichgräber, Hans-Joachim Mentzel
OBJECTIVE: The aim of this study was to evaluate and compare changes in T1-weighted signal intensity (SI) within the dentate nucleus (DN) and globus pallidus (GP) in a pediatric population after serial applications of the linear gadolinium-based magnetic resonance contrast medium gadopentetate dimeglumine and the more stable macrocyclic agent gadobutrol. MATERIALS AND METHODS: Institutional review board approval was obtained. Two similar pediatric patient cohorts who underwent at least 3 serial contrast-enhanced magnetic resonance imaging (MRI) examinations with sole application of gadopentetate dimeglumine or gadobutrol were analyzed...
October 2, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28971799/human-and-nonhuman-primate-meninges-harbor-lymphatic-vessels-that-can-be-visualized-noninvasively-by-mri
#13
Martina Absinta, Seung-Kwon Ha, Govind Nair, Pascal Sati, Nicholas J Luciano, Maryknoll Palisoc, Antoine Louveau, Kareem A Zaghloul, Stefania Pittaluga, Jonathan Kipnis, Daniel S Reich
Here, we report the existence of meningeal lymphatic vessels in human and nonhuman primates (common marmoset monkeys) and the feasibility of noninvasively imaging and mapping them in vivo with high-resolution, clinical MRI. On T2-FLAIR and T1-weighted black-blood imaging, lymphatic vessels enhance with gadobutrol, a gadolinium-based contrast agent with high propensity to extravasate across a permeable capillary endothelial barrier, but not with gadofosveset, a blood-pool contrast agent. The topography of these vessels, running alongside dural venous sinuses, recapitulates the meningeal lymphatic system of rodents...
October 3, 2017: ELife
https://www.readbyqxmd.com/read/28969373/glymphatic-mri-in-idiopathic-normal-pressure-hydrocephalus
#14
Geir Ringstad, Svein Are Sirirud Vatnehol, Per Kristian Eide
The glymphatic system has in previous studies been shown as fundamental to clearance of waste metabolites from the brain interstitial space, and is proposed to be instrumental in normal ageing and brain pathology such as Alzheimer's disease and brain trauma. Assessment of glymphatic function using magnetic resonance imaging with intrathecal contrast agent as a cerebrospinal fluid tracer has so far been limited to rodents. We aimed to image cerebrospinal fluid flow characteristics and glymphatic function in humans, and applied the methodology in a prospective study of 15 idiopathic normal pressure hydrocephalus patients (mean age 71...
October 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28952018/effects-of-serial-macrocyclic-based-contrast-materials-gadoterate-meglumine-and-gadobutrol-administrations-on-gadolinium-related-dentate-nuclei-signal-increases-in-unenhanced-t1-weighted-brain-a-retrospective-study-in-158-multiple-sclerosis-ms-patients
#15
Alessandra Splendiani, Marco Perri, Claudia Marsecano, Valentina Vellucci, Giulia Michelini, Antonio Barile, Ernesto Di Cesare
PURPOSE: To perform T1 signal intensity (SI) measurements in the dentate nuclei of adult patients with confirmed multiple sclerosis (MS) after serial administrations of the macrocyclic gadolinium-based contrast agents (GBCAs), gadoterate meglumine and gadobutrol. MATERIALS AND METHODS: This retrospective study was approved by the institutional review board and informed consent was waived. A review of our PACS database for the period from March 1, 2007 to July 31, 2016 revealed 158 confirmed MS patients who received exclusively either gadoterate meglumine (n = 81) or gadobutrol (n = 77) for diagnosis and follow-up...
September 27, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28932122/gadobutrol-in-india-a-comprehensive-review-of-safety-and-efficacy
#16
REVIEW
Jan Endrikat, Nicoletta Anzalone
Gadobutrol is a gadolinium (Gd)-based contrast agent for magnetic resonance imaging (MRI). In India, gadobutrol is approved for MRI of the central nervous system (CNS), liver, kidneys, breast and for MR angiography for patients 2 years and older. The standard dose for all age groups is 0.1 mmol/kg body weight. The safety profile has been demonstrated in 42 clinical phase 2 to 4 studies (>6800 patients), 7 observational studies, and by assessing pharmacovigilance data of 29 million applications. Furthermore, studies in children, adults, and elderly and in patients with impaired liver or kidney function did not show any increased adverse event rate...
2017: Magnetic Resonance Insights
https://www.readbyqxmd.com/read/28913611/prospective-intraindividual-comparison-of-gadoterate-and-gadobutrol-for-cervical-and-intracranial-contrast-enhanced-magnetic-resonance-angiography
#17
Philip Hoelter, Stefan Lang, Marina Weibart, Manuel Schmidt, Michael F X Knott, Tobias Engelhorn, Marco Essig, Stephan Kloska, Arnd Doerfler
PURPOSE: Gadobutrol (GB) is reported to provide improved relaxivity and concentration compared to gadoterate (GT). This study was designed to intraindividually compare quantitative and qualitative enhancement characteristics of GB to GT in cervicocranial magnetic resonance angiography (MRA) of patients with cerebrovascular disease (CVD). METHODS: Patients (n = 54) with CVD underwent two identical contrast-enhanced magnetic resonance angiography (CE-MRA) examinations of the cervical and intracranial vasculature in randomized order, using GB and GT in equimolar dose...
December 2017: Neuroradiology
https://www.readbyqxmd.com/read/28885891/signal-enhancement-of-the-dentate-nucleus-at-unenhanced-mr-imaging-after-very-high-cumulative-doses-of-the-macrocyclic-gadolinium-based-contrast-agent-gadobutrol-an-observational-study
#18
Atle Bjørnerud, Svein Are Sirirud Vatnehol, Christopher Larsson, Paulina Due-Tønnessen, Per Kristian Hol, Inge Rasmus Groote
Purpose To test for measurable visual enhancement of the dentate nucleus (DN) on unenhanced T1-weighted magnetic resonance (MR) images in a cohort of patients with a primary brain tumor who had not received linear gadolinium-based contrast agents (GBCAs) but had received many injections of macrocyclic GBCAs. Materials and Methods Seventeen patients with high-grade gliomas who had received 10-44 administrations of the macrocyclic GBCA gadobutrol (0.1 mmol/kg of body weight) were retrospectively included in this regional ethics committee-approved study...
November 2017: Radiology
https://www.readbyqxmd.com/read/28796722/accuracy-and-repeatability-of-automated-injector-versus-manual-administration-of-an-mri-contrast-agent-results-of-a-laboratory-study
#19
Jan Endrikat, Ron Barbati, Marcella Scarpa, Gregor Jost, Arthur E Ned Uber
OBJECTIVE: The aim of this study was to compare flow rates over time and the deviations from the target flow rate of a magnetic resonance imaging contrast agent achieved by an automated injector versus manual injection. MATERIALS AND METHODS: In this laboratory study, the magnetic resonance contrast agent gadobutrol was repeatedly injected by an injector and by 10 experienced technologists. Six scenarios with 2 different target flow rates (1 and 5 mL/s), 2 different contrast volumes (10 and 20 mL), and 2 different intravenous (IV) catheters (22 gauge and 20 gauge) were tested...
August 7, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28742734/evaluation-of-gadolinium-retention-after-serial-administrations-of-a-macrocyclic-gadolinium-based-contrast-agent-gadobutrol-a-single-institution-experience-with-189-patients
#20
Roh-Eul Yoo, Chul-Ho Sohn, Koung Mi Kang, Tae Jin Yun, Seung Hong Choi, Ji-Hoon Kim, Sun-Won Park
OBJECTIVE: There has been controversy as to whether gadobutrol, one of the widely used macrocyclic gadolinium-based contrast agents, can lead to gadolinium retention after serial injections. Our aim was to validate whether serial administrations of gadobutrol can cause signal increase in the dentate nucleus (DN) and globus pallidus (GP) on unenhanced T1-weighted magnetic resonance (MR) images due to gadolinium retention. MATERIALS AND METHODS: A total of 189 patients who had undergone at least 2 contrast-enhanced MR scans using only gadobutrol between August 2009 and August 2016 were retrospectively included...
July 24, 2017: Investigative Radiology
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