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Mansi R Shah, Milana Flusberg, Viktoriya Paroder, Alla M Rozenblit, Victoria Chernyak
PURPOSE: The purpose was to compare hepatic arterial phase (HAP) respiratory motion artifact (RMA) between gadoxetate, gadobutrol, gadopentetate, and gadobenate. MATERIALS/METHODS: Two hundred cases of each gadolinium agent were included. RMA was assigned using 5-point Likert scale (1=no motion, 5=extreme motion) on precontrast and HAP. RMA increase (increase ≥1 on HAP from precontrast) was the outcome in logistic regression. RESULTS: Odds of RMA increase for gadoxetate were 5...
September 13, 2016: Clinical Imaging
Animesh Tandon, Lorraine James, Markus Henningsson, René M Botnar, Amanda Potersnak, Gerald F Greil, Tarique Hussain
BACKGROUND: The use of gadolinium contrast agents in cardiovascular magnetic resonance is well-established and serves to improve both vascular imaging as well as enable late gadolinium enhancement (LGE) imaging for tissue characterization. Currently, gadofosveset trisodium, an intravascular contrast agent, combined with a three-dimensional inversion recovery balanced steady state free precession (3D IR bSSFP) sequence, is commonly used in pediatric cardiac imaging and yields excellent vascular imaging, but cannot be used for late gadolinium enhancement...
October 5, 2016: Journal of Cardiovascular Magnetic Resonance
Bing Fan, Meijiao Li, Xiaoying Wang, Yufeng Xu, Feiyu Li, Laiyun Zhang, Jian Jiang, Yanyan Jiang
PURPOSE: To compare gadobutrol and gadopentetate dimeglumine (Gd-DTPA) contrast-enhanced magnetic resonance imaging (MRI) at 3T for visualizing brain metastases. MATERIALS AND METHODS: The present randomized study included 60 consecutive patients with known or suspected brain metastases from systemic malignancies. Two enhanced cerebral MR scans were performed in each patient within an interval of 2-5 days using different contrast agents (gadobutrol or Gd-DTPA) at 3T...
October 3, 2016: Journal of Magnetic Resonance Imaging: JMRI
Daniella F Pinho, Naama Lev-Cohain, Haitham Awdeh, Yin Xi, Gaurav Khatri, Takeshi Yokoo, Ivan Pedrosa
PURPOSE: To compare a protocol with higher concentration macrocyclic gadolinium-based contrast agent (GBCA) [study group] to the traditional protocol with lower-concentration linear GBCAs [control group] for breath-held arterial phase magnetic resonance imaging. MATERIAL AND METHODS: A total of 136 patients were quantitatively evaluated for image quality (IQ), breathing artifacts (BA), and timing of the arterial phase (Tap). Quantitative analysis was also performed...
September 4, 2016: Clinical Imaging
Ludwig Schlemm, Claudia Chien, Judith Bellmann-Strobl, Jan Dörr, Jens Wuerfel, Alexander U Brandt, Friedemann Paul, Michael Scheel
BACKGROUND: Previous studies have postulated an association between dentate nucleus T1 hyperintensity and multiple sclerosis (MS)-related progressive neurodegeneration. Therefore, MS patients have been excluded from most studies investigating brain deposition of gadolinium-based contrast agents (GBCAs). OBJECTIVE: To study the hypothesis that dentate nucleus T1 hyperintensity in MS patients is associated with GBCA administration. METHODS: In a cohort of 97 MS patients, the dentate-to-pons signal intensity ratio (DPSIR) was calculated for 265 consecutive T1-weighted magnetic resonance (MR) scans (including sessions with and without the administration of GBCA)...
September 27, 2016: Multiple Sclerosis: Clinical and Laboratory Research
Devang Padalia, Corey Reeves, Enrique Galang
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
Thibault Caspar, Anthony Schultz, Mickaël Schaeffer, Aïssam Labani, Mi-Young Jeung, Paul Thomas Jurgens, Soraya El Ghannudi, Catherine Roy, Mickaël Ohana
OBJECTIVES: To compare cine MR b-TFE sequences acquired before and after gadolinium injection, on a 3T scanner with a parallel RF transmission technique in order to potentially improve scanning time efficiency when evaluating LV function. METHODS: 25 consecutive patients scheduled for a cardiac MRI were prospectively included and had their b-TFE cine sequences acquired before and right after gadobutrol injection. Images were assessed qualitatively (overall image quality, LV edge sharpness, artifacts and LV wall motion) and quantitatively with measurement of LVEF, LV mass, and telediastolic volume and contrast-to-noise ratio (CNR) between the myocardium and the cardiac chamber...
2016: PloS One
Yusuhn Kang, Ja-Young Choi, Hye Jin Yoo, Sung Hwan Hong, Heung Sik Kang
Purpose To compare the delayed gadolinium-enhanced magnetic resonance (MR) imaging of cartilage (dGEMRIC) indexes acquired with different gadolinium-based contrast agents (GBCAs), with emphasis on the difference in electrical charge, and to evaluate the feasibility of the use of GBCAs other than gadopentetate dimeglumine with a double negative charge (Gd-DTPA(2-)) as alternatives at dGEMRIC. Materials and Methods Intact porcine patellae (n = 44) were divided into four groups according to GBCA used: Gd-DTPA(2-), double negative gadobenate dimeglumine (Gd-BOPTA(2-)), single negative gadoterate meglumine (Gd-DOTA(-)), and nonionic gadobutrol (Gd-DT-DO3A)...
September 20, 2016: Radiology
Gang Wu, Teng Jin, Ting Li, John Morelli, Xiaoming Li
The aim of this study was to compare diagnostic value of high spatial resolution time-resolved magnetic resonance angiography with interleaved stochastic trajectory (TWIST) using Gadobutrol to Computed tomography angiography (CTA) for preoperative evaluation of lower extremity tumors.This prospective study was approved by the institutional review board. Fifty consecutive patients (31 men, 19 women, age range 18-80 years, average age 42.7 years) with lower extremity tumors underwent TWIST magnetic resonance angiography (MRA) and CTA...
September 2016: Medicine (Baltimore)
Gang Wu, Teng Jin, Ting Li, Xiaoming Li
PURPOSE: To evaluate the diagnostic value of time resolved magnetic resonance angiography with interleaved stochastic trajectory (TWIST) using Gadobutrol for preoperative evaluation of lower extremity tumors. MATERIALS AND METHODS: This prospective study was approved by the local Institutional Review Board. 50 consecutive patients (31 men, 19 women, age range 18-80 years, average age 42.7 years) with lower extremity tumors underwent TWIST and computed tomography angiography (CTA)...
2016: European Journal of Radiology Open
Xinfa Pan, Yongfu Lu, Liang Wen, Xiujue Zheng, Yuehui Ma
BACKGROUND: Timely diagnosis of meningeal carcinomatosis is often difficult even with the assistant of magnetic resonance imaging examination, cerebrospinal fluid analysis, or both. To the best of our knowledge, gadobutrol-enhanced MRI has not been reported in the diagnosis of meningeal carcinomatosis. Here we present two cases where meningeal carcinomatosis was identified on gadobutrol-enhanced magnetic resonance imaging. CASE PRESENTATION: We identified two cases of meningeal carcinomatosis who had been diagnosed with malignant tumors several years ago...
2016: BMC Neurology
Or Cohen-Inbar, Zhiyuan Xu, Blair Dodson, Tanvir Rizvi, Christopher R Durst, Sugoto Mukherjee, Jason P Sheehan
The radiological detection of brain metastases (BMs) is essential for optimizing a patient's treatment. This statement is even more valid when stereotactic radiosurgery, a noninvasive image guided treatment that can target BM as small as 1-2 mm, is delivered as part of that care. The timing of image acquisition after contrast administration can influence the diagnostic sensitivity of contrast enhanced magnetic resonance imaging (MRI) for BM. Investigate the effect of time delayed acquisition after administration of intravenous Gadavist® (Gadobutrol 1 mmol/ml) on the detection of BM...
August 27, 2016: Journal of Neuro-oncology
Weicui Chen, Bo Liu, Jun Chen, Guoqing Liu, Xian Liu
BACKGROUND: Immunoliposomes have been used to deliver MR contrast agents to cancer tissue by targeting tumor associated antigens, thus enabling the visualization of biological processes at the cellular level. PURPOSE: To develop and evaluate the feasibility of specific HER2 targeted liposomal MR contrast agent. MATERIAL AND METHODS: Gd-loaded anti-HER2 immunolipomes (Gd-ILs) and non-targeted PEGylated liposomes (Gd-NTLs) were prepared and characterized...
August 26, 2016: Acta Radiologica
Tobias Rutz, Davide Piccini, Simone Coppo, Jerome Chaptinel, Giulia Ginami, Gabriella Vincenti, Matthias Stuber, Juerg Schwitter
The border zone of post-infarction myocardial scar as identified by late gadolinium enhancement (LGE) has been identified as a substrate for arrhythmias and consequently, high-resolution 3D scar information is potentially useful for planning of electrophysiological interventions. This study evaluates the performance of a novel high-resolution 3D self-navigated free-breathing inversion recovery magnetic resonance pulse sequence (3D-SN-LGE) vs. conventional 2D breath-hold LGE (2D-LGE) with regard to sharpness of borders (SBorder) of post-infarction scar...
August 22, 2016: International Journal of Cardiovascular Imaging
Edyta Blaszczyk, Agnieszka Töpper, Luisa Schmacht, Felix Wanke, Andreas Greiser, Jeanette Schulz-Menger, Florian von Knobelsdorff-Brenkenhoff
OBJECTIVE: Our aim was to study the influence of small variations in spatial resolution and contrast agent dosage on myocardial T1 relaxation time. MATERIALS AND METHODS: Twenty-nine healthy volunteers underwent cardiovascular magnetic resonance at 3T twice, including a modified look-locker inversion recovery (MOLLI) technique-3(3)3(3)5-for T1 mapping. Native T1 was assessed in three spatial resolutions (voxel size 1.4 × 1.4 × 6, 1.6 × 1.6 × 6, 1.7 × 1...
August 20, 2016: Magma
Henrik J Michaely, Manuela Aschauer, Hannes Deutschmann, Georg Bongartz, Matthias Gutberlet, Ramona Woitek, Birgit Ertl-Wagner, Walter Kucharczyk, Renate Hammerstingl, Francesco De Cobelli, Martin Rosenberg, Thomas Balzer, Jan Endrikat
OBJECTIVE: The aim of this study was to assess the potential risk of gadobutrol-enhanced magnetic resonance imaging (MRI) in patients with moderate to severe renal impairment for the development of nephrogenic systemic fibrosis (NSF). MATERIALS AND METHODS: We performed a prospective, international, multicenter, open-label study in 55 centers. Patients with moderate to severe renal impairment scheduled for any gadobutrol-enhanced MRI were included. All patients received a single intravenous bolus injection of gadobutrol at a dose of 0...
August 15, 2016: Investigative Radiology
Alexander Radbruch, Lukas D Weberling, Pascal J Kieslich, Johanna Hepp, Philipp Kickingereder, Wolfgang Wick, Heinz-Peter Schlemmer, Martin Bendszus
PURPOSE: Recent studies reported an increase in the dentate nucleus (DN)-to-pons signal intensity (SI) ratio (DN-pons SI ratio) on unenhanced T1-weighted images in patients who received consecutive serial injections of linear gadolinium-based contrast agents (GBCAs). In contrast, most studies found no increase in the DN-pons SI ratio when patients were treated with consecutive serial injections of macrocyclic GBCAs. However, the potential difference between macrocyclic and linear GBCAs has never been assessed in individuals who received subsequent applications of both contrast agents...
November 2016: Investigative Radiology
Heike Breuer, Martin Meier, Sophie Schneefeld, Wolfgang Härtig, Alexander Wittneben, Martin Märkel, Tobias L Ross, Frank M Bengel, Marion Bankstahl, Jens P Bankstahl
Insult-associated blood-brain barrier leakage is strongly suggested to be a key step during epileptogenesis. In this study, we used three non-invasive translational imaging modalities, i.e. positron emission tomography, single photon emission computed tomography, and magnetic resonance imaging, to evaluate BBB leakage after an epileptogenic brain insult. Sprague-Dawley rats were scanned during early epileptogenesis initiated by status epilepticus. Positron emission tomography and single photon emission computed tomography scans were performed using the novel tracer [(68)Ga]DTPA or [(99m)Tc]DTPA, respectively...
July 19, 2016: Journal of Cerebral Blood Flow and Metabolism
Gunther Helms, Christina Schlumbohm, Enrique Garea-Rodriguez, Peter Dechent, Eberhard Fuchs
BACKGROUND: This study determined the pharmacokinetics of the contrast agent gadobutrol in marmosets by quantitative MRI to derive guidelines for neuroimaging protocols. METHODS: Local concentrations of gadobutrol were determined from consecutive gradient echo-based mapping of the relaxation rate R1 on a clinical 3T MRI scanner. Half-time of renal elimination was measured after injection of a triple dose of gadobutrol (0.3 mmol/kg) into the saphenous vein. A first-order single-compartment model was fitted to the measured R1 values and verified by blood analysis...
July 15, 2016: Journal of Medical Primatology
Tae Won Choi, Jeong Min Lee, Jung Hoon Kim, Mi Hye Yu, Joon Koo Han, Byung Ihn Choi
OBJECTIVE: To compare multidetector computed tomography (MDCT) and MRI for lesion conspicuity, as well as the detection and characterization of small solid pancreatic lesions (SPLs). MATERIALS AND METHODS: 193 patients with small SPLs (< 3 cm) and 52 patients with normal pancreas who underwent both multiphasic MDCT and gadobutrol-enhanced MRI were included in our study. Two radiologists blinded to the pathologic diagnoses independently reviewed those images, and determined the detection of "SPL per se" and "SPL in consideration of secondary features", the lesion conspicuity, the probability of pancreatic ductal adenocarcinoma (PDAC), and the most likely specific diagnosis...
July 2016: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
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