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https://www.readbyqxmd.com/read/28782578/performance-of-rapid-diagnostic-tests-for-detection-of-hepatitis-b-and-c-markers-in-hiv-infected-patients
#1
Jakeline Ribeiro Barbosa, Jeová Keny Baima Colares, Geane Lopes Flores, Vanessa Faria Cortes, Juliana Custódio Miguel, Moyra Machado Portilho, Vanessa Alves Marques, Denise Vigo Potsch, Carlos Eduardo Brandão-Mello, Marcia Amendola-Pires, José Henrique Pilotto, Danielle Malta Lima, Elisabeth Lampe, Livia Melo Villar
There is little information describing the influence of HIV infection upon the performance of rapid diagnostic tests (RDTs) for hepatitis B and C virus diagnosis. This study aims to evaluate the performance of RDTs for HBsAg and anti-HCV detection among HIV-infected individuals. A total of 362 HIV infected individuals were recruited from clinics between January 2013 to November 2014 in the southeast and northeast of Brazil. HBsAg and anti-HCV were detected using commercial EIAs and four RDTs: HBV (Vikia HBsAg(®) and Wama Imuno-Rapido HBV(®)) and HCV (Bioeasy Teste Rápido HCV(®) and Wama Imuno-Rapido HCV(®))...
August 4, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28774417/treatment-of-hepatitis-b-virus-with-combination-therapy-now-and-in-the-future
#2
REVIEW
Joel S Emery, Jordan J Feld
Chronic Hepatitis B continues as a significant public health problem despite the availability of safe and effective antivirals and a highly effective protective vaccine. Current therapy, however rarely leads to cure and lifelong therapy is often required, contributing to poor uptake and ongoing morbidity. New insights into the hepatitis B viral life cycle and the host immune response have expanded the potential targets for drug therapies with interesting antiviral candidates and novel immunotherapeutic approaches in early stage development...
June 2017: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/28769934/human-leukocyte-antigen-hla-and-immune-regulation-how-do-classical-and-non-classical-hla-alleles-modulate-immune-response-to-human-immunodeficiency-virus-and-hepatitis-c-virus-infections
#3
REVIEW
Nicole B Crux, Shokrollah Elahi
The genetic factors associated with susceptibility or resistance to viral infections are likely to involve a sophisticated array of immune response. These genetic elements may modulate other biological factors that account for significant influence on the gene expression and/or protein function in the host. Among them, the role of the major histocompatibility complex in viral pathogenesis in particular human immunodeficiency virus (HIV) and hepatitis C virus (HCV), is very well documented. We, recently, added a novel insight into the field by identifying the molecular mechanism associated with the protective role of human leukocyte antigen (HLA)-B27/B57 CD8(+) T cells in the context of HIV-1 infection and why these alleles act as a double-edged sword protecting against viral infections but predisposing the host to autoimmune diseases...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28723711/epidemiology-of-autoimmune-and-inflammatory-diseases-in-a-french-nationwide-hiv-cohort
#4
D Lebrun, M Hentzien, L Cuzin, D Rey, V Joly, L Cotte, C Allavena, P Dellamonica, A Servettaz, F Bani-Sadr
HIV infection and inflammatory and autoimmune diseases (IAD) are both related to immune dysfunction. Epidemiological data on IAD in patients living with HIV (PLHIV) are scarce. The aim of this study was thus to estimate the prevalence of 26 IAD among PLHIV followed in a large French multicenter cohort in the cART era (from January 2000 to July 2013), and to describe their occurrence according to cART onset, the immuno-virological status of patients and HCV and/or HBV co-infection.During the study period, 33 403 PLHIV were included in the Dat'AIDS cohort; 1381 patients with an IAD were identified...
July 18, 2017: AIDS
https://www.readbyqxmd.com/read/28707319/tenofovir-disoproxil-fumarate-significantly-decreases-serum-lipoprotein-levels-compared-with-entecavir-nucleos-t-ide-analogue-therapy-in-chronic-hepatitis-b-carriers
#5
A A Shaheen, M AlMattooq, S Yazdanfar, K W Burak, M G Swain, S E Congly, M A Borman, S S Lee, R P Myers, C S Coffin
BACKGROUND: Tenofovir disoproxil fumarate (TDF) and entecavir (ETV) are first-line treatments for chronic hepatitis B (CHB). Studies suggest lipid lowering effect of TDF in human immunodeficiency virus positive (HIV+) individuals, but the effect on lipids and cardiovascular disease (CVD) risk in CHB is unknown. AIM: To compare TDF vs ETV effects on lipid levels in CHB. METHODS: In this retrospective cohort study, data on serum lipids and CVD risk factors at baseline and ~1 year on TDF or ETV were collected from CHB carriers...
July 13, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28681826/prevalence-of-transfusion-transmitted-viral-pathogens-among-health-care-workers-and-risk-mitigation-programme-in-a-paediatric-tertiary-care-hospital
#6
Charu Nayyar, Rushika Saksena, Vikas Manchanda
The health-care workers (HCWs) are at an occupational risk of exposure to blood-borne pathogens, mainly, HIV, hepatitis B virus (HBV) and hepatitis C virus. HBV is currently the only blood-borne virus for which a vaccine is available. All health-care institutions must encourage the HCWs to undergo screening for blood-borne pathogens.
April 2017: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28678865/transfusion-transmissible-viral-infections-among-blood-donors-at-the-north-gondar-district-blood-bank-northwest-ethiopia-a-three-year-retrospective-study
#7
Belete Biadgo, Elias Shiferaw, Berhanu Woldu, Kefyalew Addis Alene, Mulugeta Melku
BACKGROUND: Transfusion-transmissible viral infections, such as hepatitis C virus (HCV), hepatitis B virus (HBV), and human immunodeficiency virus (HIV), remain a major public health problem in developing countries. The prevalence of these viral infections among blood donors may reflect the burden of these diseases among populations. Therefore, the aim of this study was to assess the sero-prevalence of transfusion-transmissible viral infections among blood donors. METHODS: A retrospective study was conducted using data obtained from registration books of blood donors from the Ethiopian North Gondar District Blood Bank from 2010 to 2012...
2017: PloS One
https://www.readbyqxmd.com/read/28636651/yield-of-yearly-routine-physical-examination-in-hiv-1-infected-patients-is-limited-a-retrospective-cohort-study-in-the-netherlands
#8
Marleen A van Amsterdam, Sander van Assen, Herman G Sprenger, Kasper R Wilting, Ymkje Stienstra, Wouter F W Bierman
BACKGROUND: Routine physical examinations might be of value in HIV-infected patients, but the yield is unknown. We determined the diagnoses that would have been missed without performing annual routine physical examinations in HIV-infected patients with stable disease. METHODS: Data were collected from the medical records of 299 HIV-1-infected patients with CD4 count >350 cells/mm3 if not using combination antiretroviral therapy (cART), or CD4 count >100 cells/mm3 and undetectable viral load if using cART...
2017: PloS One
https://www.readbyqxmd.com/read/28632974/hcv-positive-donor-organs-in-solid-organ-transplantation-mind-the-gap
#9
EDITORIAL
J A Fishman, X Forns
The shortage of organs for transplantation is a major impediment to access to life-saving therapy. The availability of antiviral therapies that control hepatitis B (HBV) and HIV, or cure hepatitis C (HCV), have changed traditional equations in transplantation, allowing infected individuals access to transplantation without unimpeded viral replication during immunosuppression. The availability of these therapies also permits use of organs from donors actively or potentially infected with these viruses. This article is protected by copyright...
June 20, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28621653/increased-mortality-among-indigenous-persons-in-a-multisite-cohort-of-people-living-with-hiv-in-canada
#10
MULTICENTER STUDY
Anita C Benoit, Jaime Younger, Kerrigan Beaver, Randy Jackson, Mona Loutfy, Renée Masching, Tony Nobis, Earl Nowgesic, Doe O'Brien-Teengs, Wanda Whitebird, Art Zoccole, Mark Hull, Denise Jaworsky, Elizabeth Benson, Anita Rachlis, Sean B Rourke, Ann N Burchell, Curtis Cooper, Robert S Hogg, Marina B Klein, Nima Machouf, Julio S G Montaner, Chris Tsoukas, Janet Raboud
OBJECTIVE: Compare all-cause mortality between Indigenous participants and participants of other ethnicities living with HIV initiating combination antiretroviral therapy (cART) in an interprovincial multi-site cohort. METHODS: The Canadian Observational Cohort is a collaboration of 8 cohorts of treatment-naïve persons with HIV initiating cART after January 1, 2000. Participants were followed from the cART initiation date until death or last viral load (VL) test date on or before December 31, 2012...
June 16, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28598793/croi-2017-highlights-of-advances-in-viral-hepatitis-and-liver-fibrosis
#11
Anne F Luetkemeyer, David L Wyles
At the 2017 Conference on Retroviruses and Opportunistic Infections (CROI) in Seattle, Washington, hepatitis C virus (HCV) infection was a major focus in the context of HIV-associated liver disease. Well-tolerated direct-acting antiviral (DAA) regimens have enabled effective treatment of the populations that are hardest to cure, including those with decompensated cirrhosis, and many studies examined the impact of HCV cure on hepatitis and extrahepatic outcomes. Scaling up access to DAA, and the impact that their universal availability can have on reducing prevalence were key topics...
May 2017: Topics in Antiviral Medicine
https://www.readbyqxmd.com/read/28586700/injection-into-the-jugular-vein-among-people-who-inject-drugs-in-the-united-kingdom-prevalence-associated-factors-and-harms
#12
Vivian D Hope, Jenny Iversen, Katelyn J Cullen, John V Parry, Lisa Maher, Fortune Nucbe
BACKGROUND: While people who inject drugs (PWID) typically use peripheral veins, some inject into their central veins, including the femoral and jugular veins. Injection into the jugular vein can have serious adverse health consequences, including jugular vein thrombosis, deep neck infections, pneumothorax, endocarditis and sepsis. This study examined the prevalence of, and factors associated with, jugular vein injection among a large sample of PWID in the United Kingdom. METHOD: Unlinked anonymous surveys (2011-14) recruited PWID from agencies providing services to this population...
June 3, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28579170/vaccination-coverage-in-a-cohort-of-hiv-infected-patients-receiving-care-at-an-aids-outpatient-clinic-in-esp%C3%A3-rito-santo-brazil
#13
Lauro Ferreira da Silva Pinto Neto, Julia Vescovi Vieira, Nathália Rossoni Ronchi
This cross-sectional study assessed the immunization status of human immune deficiency virus (HIV)-infected patients receiving care at an outpatient clinic in Brazil. The sociodemographic characteristics, CD4 count and HIV viral load of 281 out of 612 adult outpatients were analyzed. A total of 331 patients were excluded because of no availability of vaccination cards. Chi-square or Fisher's exact test were used. Immunization coverage was higher for diphtheria/tetanus (59.79%) and hepatitis B (56.7%), and lowest for hepatitis A (6...
June 1, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28562715/evaluation-of-hiv-sti-and-cd4-results-among-voluntary-attendees-at-the-hiv-aids-program-of-mexico-city
#14
Luis Alfredo Juárez-Figueroa, Felipe Javier Uribe-Salas, Andrea González-Rodríguez, Patricia Iracheta-Hernández, Verónica Ruiz-González, Yazmín Medina-Islas
Objective: To describe results of HIV, sexually transmitted diseases (STI) and CD4 counts at the HIV-specialized Condesa Clinic (CC) in Mexico City. Materials and methods: Individuals who requested voluntary counseling and testing at CC were studied. We identified antibodies against HIV, syphilis, hepatitis C, and hepatitis B HBsAg. CD4 cell counts and viral load of HIV positive individuals were also obtained. Late HIV infection diagnosis was established if CD4 counts were lower than 200 cells/μL...
March 2017: Salud Pública de México
https://www.readbyqxmd.com/read/28497525/risk-of-end-stage-renal-disease-in-hiv-positive-potential-live-kidney-donors
#15
A D Muzaale, K N Althoff, C J Sperati, A G Abraham, L M Kucirka, A B Massie, M M Kitahata, M A Horberg, A C Justice, M J Fischer, M J Silverberg, A A Butt, S L Boswell, A R Rachlis, A M Mayor, M J Gill, J J Eron, S Napravnik, D R Drozd, J N Martin, R J Bosch, C M Durand, J E Locke, R D Moore, G M Lucas, D L Segev
New federal regulations allow HIV-positive individuals to be live kidney donors; however, potential candidacy for donation is poorly understood given the increased risk of end-stage renal disease (ESRD) associated with HIV infection. To better understand this risk, we compared the incidence of ESRD among 41 968 HIV-positive participants of North America AIDS Cohort Collaboration on Research and Design followed for a median of 5 years with the incidence of ESRD among comparable HIV-negative participants of National Health and Nutrition Examination III followed for a median of 14 years...
July 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28488960/towards-pathogen-inactivation-of-red-blood-cells-and-whole-blood-targeting-viral-dna-rna-design-technologies-and-future-prospects-for-developing-countries
#16
REVIEW
Victor J Drew, Lassina Barro, Jerard Seghatchian, Thierry Burnouf
Over 110 million units of blood are collected yearly. The need for blood products is greater in developing countries, but so is the risk of contracting a transfusion-transmitted infection. Without efficient donor screening/viral testing and validated pathogen inactivation technology, the risk of transfusion-transmitted infections correlates with the infection rate of the donor population. The World Health Organization has published guidelines on good manufacturing practices in an effort to ensure a strong global standard of transfusion and blood product safety...
April 13, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28480234/estimating-the-time-to-diagnosis-and-the-chance-of-spontaneous-clearance-during-acute-hepatitis-c-in-human-immunodeficiency-virus-infected-individuals
#17
Romain Ragonnet, Sylvie Deuffic-Burban, Christoph Boesecke, Marguerite Guiguet, Karine Lacombe, Jeremie Guedj, Jürgen K Rockstroh, Yazdan Yazdanpanah
BACKGROUND: Hepatitis C virus (HCV) infection is often asymptomatic, and the date of infection is almost impossible to determine. Furthermore, spontaneous clearance (SC) may occur, but little is known about its time of occurrence. METHODS: Data on human immunodeficiency virus (HIV)-HCV coinfected individuals were used to inform a stochastic simulation model of HCV viral load kinetics, alanine aminotransferase (ALT), and HCV antibodies during acute hepatitis C. The dates of diagnosis and potential SC were estimated through a Bayesian approach...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28475637/assessment-of-hepatitis-c-virus-infection-in-two-adjacent-thai-provinces-with-drastically-different-seroprevalence
#18
Rujipat Wasitthankasem, Preeyaporn Vichaiwattana, Nipaporn Siripon, Nawarat Posuwan, Chompoonut Auphimai, Sirapa Klinfueng, Napha Thaneskongtong, Viboonsak Vuthitanachot, Supapith Saiyatha, Chaiwat Thongmai, Sarawut Suwanpatoomlerd, Saowakon Sochoo, Natnada Pongsuwan, Kittiyod Poovorawan, Pisit Tangkijvanich, Sompong Vongpunsawad, Yong Poovorawan
Improved awareness of the hepatitis C virus (HCV) transmission has contributed to the overall decline in the HCV infection rate in some developing countries including Thailand. Chronic HCV infection in some rural Thai communities, however, presents a challenge in the efforts to treat and manage HCV-related diseases. Published and unpublished studies have suggested an unusually high incidence of HCV infection in a Thai province of Phetchabun compared to elsewhere in Thailand. To determine the magnitude of HCV infection and identify potential factors contributing to the higher rate of HCV infection in this province, we performed a population-based study in Phetchabun (n = 1667) and the neighboring Khon Kaen province (n = 1410) where HCV prevalence is much lower...
2017: PloS One
https://www.readbyqxmd.com/read/28471765/impact-of-aging-on-neurocognitive-performance-in-previously-antiretroviral-naive-hiv-infected-individuals-on-their-first-suppressive-regimen
#19
Hamza Coban, Kevin Robertson, Marlene Smurzynski, Supriya Krishnan, Kunling Wu, Ronald J Bosch, Ann C Collier, Ronald J Ellis
BACKGROUND: Despite treatment with virologically suppressive antiretroviral therapy (ART), neurocognitive impairment may persist or develop de novo in aging HIV-infected individuals. We evaluated advancing age as a predictor of neurocognitive impairment in a large cohort of previously ART-naive individuals on long-term ART. DESIGN: The AIDS Clinical Trials Group Longitudinal Linked Randomized Trials was a prospective cohort study of HIV-infected individuals originally enrolled in randomized ART trials...
July 17, 2017: AIDS
https://www.readbyqxmd.com/read/28465279/knowledge-attitude-behavior-and-practices-regarding-hiv-viral-hepatitis-and-sexually-transmitted-infections-among-migrants-from-sub-saharan-africa-living-in-germany-a-multicenter-survey-protocol
#20
Claudia Santos-Hövener, Carmen Koschollek, Anna Kuehne, Adama Thorlie, Viviane Bremer
BACKGROUND: Migration has an impact on the epidemiology of viral hepatitis B and C (HEP) and HIV in Germany; migrants from sub-Saharan Africa (MisSA) in Germany are disproportionally affected by HIV. In the last 10 years, a total of 10%-15% of all newly diagnosed HIV cases were among MisSA; 20%-30% of them acquired HIV in Germany. Prevalence of HEP among MisSA in Germany is unknown, but Western Africa, from where most MisSA in Germany originate, reports the highest prevalence of hepatitis B worldwide...
May 2, 2017: JMIR Research Protocols
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