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https://www.readbyqxmd.com/read/28497525/risk-of-end-stage-renal-disease-in-hiv-positive-potential-live-kidney-donors
#1
A D Muzaale, K N Althoff, C J Sperati, A G Abraham, L M Kucirka, A B Massie, M M Kitahata, M A Horberg, A C Justice, M J Fischer, M J Silverberg, A A Butt, S L Boswell, A R Rachlis, A M Mayor, M J Gill, J J Eron, S Napravnik, D R Drozd, J N Martin, R J Bosch, C M Durand, J E Locke, R D Moore, G M Lucas, D L Segev
New federal regulations allow HIV-positive individuals to be live kidney donors; however, potential candidacy for donation is poorly understood given the increased risk of end-stage renal disease (ESRD) associated with HIV infection. To better understand this risk, we compared the incidence of ESRD among 41 968 HIV-positive participants of North America AIDS Cohort Collaboration on Research and Design followed for a median of 5 years with the incidence of ESRD among comparable HIV-negative participants of National Health and Nutrition Examination III followed for a median of 14 years...
May 12, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28488960/towards-pathogen-inactivation-of-red-blood-cells-and-whole-blood-targeting-viral-dna-rna-design-technologies-and-future-prospects-for-developing-countries
#2
REVIEW
Victor J Drew, Lassina Barro, Jerard Seghatchian, Thierry Burnouf
Over 110 million units of blood are collected yearly. The need for blood products is greater in developing countries, but so is the risk of contracting a transfusion-transmitted infection. Without efficient donor screening/viral testing and validated pathogen inactivation technology, the risk of transfusion-transmitted infections correlates with the infection rate of the donor population. The World Health Organization has published guidelines on good manufacturing practices in an effort to ensure a strong global standard of transfusion and blood product safety...
April 13, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28480234/estimating-the-time-to-diagnosis-and-the-chance-of-spontaneous-clearance-during-acute-hepatitis-c-in-human-immunodeficiency-virus-infected-individuals
#3
Romain Ragonnet, Sylvie Deuffic-Burban, Christoph Boesecke, Marguerite Guiguet, Karine Lacombe, Jeremie Guedj, Jürgen K Rockstroh, Yazdan Yazdanpanah
BACKGROUND: Hepatitis C virus (HCV) infection is often asymptomatic, and the date of infection is almost impossible to determine. Furthermore, spontaneous clearance (SC) may occur, but little is known about its time of occurrence. METHODS: Data on human immunodeficiency virus (HIV)-HCV coinfected individuals were used to inform a stochastic simulation model of HCV viral load kinetics, alanine aminotransferase (ALT), and HCV antibodies during acute hepatitis C. The dates of diagnosis and potential SC were estimated through a Bayesian approach...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28475637/assessment-of-hepatitis-c-virus-infection-in-two-adjacent-thai-provinces-with-drastically-different-seroprevalence
#4
Rujipat Wasitthankasem, Preeyaporn Vichaiwattana, Nipaporn Siripon, Nawarat Posuwan, Chompoonut Auphimai, Sirapa Klinfueng, Napha Thaneskongtong, Viboonsak Vuthitanachot, Supapith Saiyatha, Chaiwat Thongmai, Sarawut Suwanpatoomlerd, Saowakon Sochoo, Natnada Pongsuwan, Kittiyod Poovorawan, Pisit Tangkijvanich, Sompong Vongpunsawad, Yong Poovorawan
Improved awareness of the hepatitis C virus (HCV) transmission has contributed to the overall decline in the HCV infection rate in some developing countries including Thailand. Chronic HCV infection in some rural Thai communities, however, presents a challenge in the efforts to treat and manage HCV-related diseases. Published and unpublished studies have suggested an unusually high incidence of HCV infection in a Thai province of Phetchabun compared to elsewhere in Thailand. To determine the magnitude of HCV infection and identify potential factors contributing to the higher rate of HCV infection in this province, we performed a population-based study in Phetchabun (n = 1667) and the neighboring Khon Kaen province (n = 1410) where HCV prevalence is much lower...
2017: PloS One
https://www.readbyqxmd.com/read/28471765/impact-of-aging-on-neurocognitive-performance-in-previously-antiretroviral-na%C3%A3-ve-hiv-individuals-on-their-first-suppressive-regimen
#5
Hamza Coban, Kevin Robertson, Marlene Smurzynski, Supriya Krishnan, Kunling Wu, Ronald J Bosch, Ann C Collier, Ronald J Ellis
BACKGROUND: Despite treatment with virologically suppressive antiretroviral therapy (ART), neurocognitive impairment may persist or develop de novo in aging HIV-infected individuals. We evaluated advancing age as a predictor of neurocognitive impairment in a large cohort of previously ART-naïve individuals on long-term ART DESIGN:: The AIDS Clinical Trials Group (ACTG) Longitudinal Linked Randomized Trials (ALLRT) was a prospective cohort study of HIV-infected individuals originally enrolled in randomized ART trials...
May 3, 2017: AIDS
https://www.readbyqxmd.com/read/28465279/knowledge-attitude-behavior-and-practices-regarding-hiv-viral-hepatitis-and-sexually-transmitted-infections-among-migrants-from-sub-saharan-africa-living-in-germany-a-multicenter-survey-protocol
#6
Claudia Santos-Hövener, Carmen Koschollek, Anna Kuehne, Adama Thorlie, Viviane Bremer
BACKGROUND: Migration has an impact on the epidemiology of viral hepatitis B and C (HEP) and HIV in Germany; migrants from sub-Saharan Africa (MisSA) in Germany are disproportionally affected by HIV. In the last 10 years, a total of 10%-15% of all newly diagnosed HIV cases were among MisSA; 20%-30% of them acquired HIV in Germany. Prevalence of HEP among MisSA in Germany is unknown, but Western Africa, from where most MisSA in Germany originate, reports the highest prevalence of hepatitis B worldwide...
May 2, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28464899/prevalence-of-hepatitis-b-and-c-infection-in-persons-living-with-hiv-enrolled-in-care-in-rwanda
#7
Justine Umutesi, Bryony Simmons, Jean D Makuza, Donatha Dushimiyimana, Aimable Mbituyumuremyi, Jean Marie Uwimana, Nathan Ford, Edward J Mills, Sabin Nsanzimana
BACKGROUND: Hepatitis B (HBV) and C (HCV) are important causes of morbidity and mortality in people living with human immunodeficiency virus (HIV). The burden of these co-infections in sub-Saharan Africa is still unclear. We estimated the prevalence of the hepatitis B surface antigen (HBsAg) and hepatitis C antibody (HCVAb) among HIV-infected individuals in Rwanda and identified factors associated with infection. METHODS: Between January 2016 and June 2016, we performed systematic screening for HBsAg and HCVAb among HIV-positive individuals enrolled at public and private HIV facilities across Rwanda...
May 2, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28464883/late-presentation-of-chronic-viral-hepatitis-for-medical-care-a-consensus-definition
#8
Stefan Mauss, Stanislas Pol, Maria Buti, Erika Duffell, Charles Gore, Jeffrey V Lazarus, Hilje Logtenberg-van der Grient, Jens Lundgren, Antons Mozalevskis, Dorthe Raben, Eberhard Schatz, Stefan Wiktor, Jürgen K Rockstroh
INTRODUCTION: We present two consensus definitions of advanced and late stage liver disease being used as epidemiological tools. These definitions can be applied to assess the morbidity caused by liver diseases in different health care systems. We focus is on hepatitis B and C virus infections, because effective and well tolerated treatments for both of these infections have greatly improved our ability to successfully treat and prevent advanced and late stage disease, especially if diagnosed early...
May 3, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28457424/what-can-we-do-when-all-collapses-fatal-outcome-of-collapsing-glomerulopathy-and-systemic-lupus-erythematosus-with-diffuse-alveolar-hemorrhage-case-report
#9
H Pinto, R Leal, L Rodrigues, L Santos, C Romãozinho, F Macário, R Alves, J Pratas, V Sousa, C Marinho, L Prado E Castro, F Costa, M Campos, A Mota, A Figueiredo
INTRODUCTION: Collapsing glomerulopathy (CG) is a rare form of glomerular injury. Although commonly associated with human immunodeficiency virus (HIV) infection, it can occur in association with systemic lupus erythematosus (SLE). CASE REPORT: We present the case of a 50-year-old man, with chronic kidney disease secondary to focal and segmental glomerulosclerosis, who received a cadaveric kidney transplant in 2007. There were no relevant intercurrences until May 2015, when he presented with nephrotic range proteinuria (± 4 g/d)...
May 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28434689/early-childhood-transmission-of-hepatitis-b-prior-to-the-first-hepatitis-b-vaccine-dose-is-rare-among-babies-born-to-hiv-infected-and-non-hiv-infected-mothers-in-gulu-uganda
#10
E Seremba, J P Van Geertruyden, R Ssenyonga, C K Opio, J M Kaducu, J B Sempa, R Colebunders, P Ocama
BACKGROUND: Hepatitis B (HBV) in sub-Saharan Africa is believed to be horizontally acquired. However, because of the high HBV prevalence in northern Uganda, no hepatitis B vaccination at birth and no access to HBV immunoglobulin, we hypothesize that vertical transmission also could also play an important role. We therefore investigated the incidence of HBV among babies presenting for their first HBV vaccine dose in Gulu, Uganda. METHODS: We recruited mothers and their babies (at least 6-week old) presenting for their postnatal care and first HBV vaccine dose respectively...
May 19, 2017: Vaccine
https://www.readbyqxmd.com/read/28419653/hcv-viraemia-associates-with-nk-cell-activation-and-dysfunction-in-antiretroviral-therapy-treated-hiv-hcv-co-infected-subjects
#11
E Papasavvas, L Azzoni, X Yin, Q Liu, J Joseph, A Mackiewicz, B Ross, K M Lynn, J M Jacobson, K Mounzer, J R Kostman, L J Montaner
The impact of hepatitis C virus (HCV) RNA levels on immune status in chronically HCV mono-infected when compared to HIV/HCV co-infected on antiretroviral therapy (ART) remains poorly understood. A total of 78 African American subjects HCV viraemic/naïve to HCV treatment (33 HCV genotype 1 mono-infected, 45 ART-treated HIV/HCV genotype 1 co-infected) were studied. Clinical and liver enzyme measurements were performed. Whole blood was analysed for immune subset changes by flow cytometry. Peripheral blood mononuclear cells (PBMC) were used for same-day constitutive and in vitro Interferon (IFN)-α-induced signal transducer and activator of transcription (STAT) phosphorylation, K562 target cell lysis and K562 target cell recognition-mediated IFN-γ production...
April 17, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28416195/pitavastatin-versus-pravastatin-in-adults-with-hiv-1-infection-and-dyslipidaemia-intrepid-12-week-and-52-week-results-of-a-phase-4-multicentre-randomised-double-blind-superiority-trial
#12
Judith A Aberg, Craig A Sponseller, Douglas J Ward, Vladimir A Kryzhanovski, Stuart E Campbell, Melanie A Thompson
BACKGROUND: People living with HIV-1 infection are at greater risk for cardiovascular disease than seronegative adults. Treatment of dyslipidaemia with statins has been challenging in people with HIV because of an increased potential for drug interactions due to competing cytochrome P450 metabolism between statins and commonly used antiretroviral agents. Neither pitavastatin nor pravastatin depend on cytochrome P450 for primary metabolism. We aimed to assess the safety and efficacy of pitavastatin versus pravastatin in adults with HIV and dyslipidaemia...
April 13, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28412679/epidemic-characteristics-of-main-infectious-diseases-in-yantai-city-between-2010-and-2012-and-prevention-strategy-research
#13
Huimin Gao, Wenbo Luan, Maobo Wang, Yanjie Dong
To investigate the epidemic characteristics and prevention strategies of main infectious diseases. From 2010 to 2012, 23 notifiable diseases were reported in Yantai with average reported cases of 17,376. The morbidity was the highest in 2012 and the lowest in 2011. The accumulated death toll was 101 with the highest death rate in 2011 and the lowest in 2012. Major class A and B infectious diseases included viral hepatitis, phthisis, syphilis, clap and dysentery. The major class C infectious disease was hand-foot-and-mouth disease every year...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28400540/cd56-bright-nk-il-7r%C3%AE-expression-negatively-associates-with-hcv-level-and-il-7-induced-nk-function-is-impaired-during-hcv-and-hiv-infections
#14
Chelsey J Judge, Lenche Kostadinova, Kenneth E Sherman, Adeel A Butt, Yngve Falck-Ytter, Nicholas T Funderburg, Alan L Landay, Michael M Lederman, Scott F Sieg, Johan K Sandberg, Donald D Anthony
Several lines of evidence support the concept that NK cells play an important role in control of hepatitis C virus (HCV) infection via cytokine secretion and cytotoxicity. IL-7 is a homeostatic cytokine with a role in T cell development, activation, proliferation, and cytokine secretion. The IL-7Rα chain [cluster of differentiation (CD)127] is expressed on NK cells, with greatest abundance on the CD56(bright)CD16(dim/-) (CD56(bright)) subset. Here, we measured CD127 expression on CD56(bright), CD56(dim)CD16(+) (CD56(dim)), or CD56(neg)CD16(+) (CD56(neg)) NK cell subsets of 25 uninfected donors (UD); 34 chronic HCV-infected, treatment-naïve; 25 HIV-infected, virally suppressed on antiretroviral therapy (ART); and 42 HCV-HIV-coinfected subjects on ART...
April 11, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28399349/sexually-transmitted-infections-prevalence-knowledge-and-behaviours-among-professional-defence-forces-in-estonia-a-pilot-study
#15
David Parker, Kristi Rüütel
OBJECTIVES: Our study assessed sexually transmitted infections (STI) occurrence and risk behaviours from a sample of the defence forces of Estonia. Previous research on military personnel yields various results on the prevalence of STIs and high risk behaviours. The increasing recognition of high risk behaviours among military personnel is evident given increased programmes that focus on education of drug use and risky sexual behaviours. Many militaries conduct routine, periodic screening for diseases such as HIV and viral hepatitis at entry and pre-foreign deployment...
March 2017: Central European Journal of Public Health
https://www.readbyqxmd.com/read/28395689/prevalence-of-hepatitis-b-hepatitis-c-and-human-immunodeficiency-viruses-and-evaluation-of-risk-factors-for-transmission-report-of-a-population-screening-in-nigeria
#16
U C Okonkwo, H Okpara, A Otu, S Ameh, Y Ogarekpe, H Osim, M Inyama
BACKGROUND: Hepatitis B virus (HBV), hepatitis C virus (HCV) and HIV are common blood-borne infections unevenly distributed across regions in Nigeria. Few population-based prevalence studies have been done in Nigeria. OBJECTIVE: To determine the prevalence of HBV, HCV and HIV and risk factors for infection with these viruses in a Nigerian population. METHODS: Hepatitis B surface antigen, anti-HCV and HIV were assayed in 1 498 healthy adult participants...
March 29, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28389206/residual-risk-of-hiv-hcv-and-hbv-in-canada
#17
Sheila F O'Brien, Qi-Long Yi, Wenli Fan, Vito Scalia, Mindy Goldman, Margaret A Fearon
BACKGROUND: Residual risk is estimated as the product of the incidence and the infectious window period, the time during which a blood donation could be infectious but the assay may not detect it. In 2011 nucleic acid multiplex testing (MPX) was implemented in 6 unit minipools (previously 24 unit minipools). MPX also included hepatitis B (HBV) NAT for the first time (complementing HBsAg screening) in addition to HIV-1 and hepatitis C (HCV) as before. We aimed to estimate window period risk-day equivalents for MPX, and the residual risk of viral infections in blood donations updated to reflect current incidence and testing...
March 18, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28376824/hepatitis-c-co-infection-is-associated-with-an-increased-risk-of-incident-chronic-kidney-disease-in-hiv-infected-patients-initiating-combination-antiretroviral-therapy
#18
Carmine Rossi, Janet Raboud, Sharon Walmsley, Curtis Cooper, Tony Antoniou, Ann N Burchell, Mark Hull, Jason Chia, Robert S Hogg, Erica E M Moodie, Marina B Klein
BACKGROUND: Combination antiretroviral therapy (cART) has reduced mortality from AIDS-related illnesses and chronic comorbidities have become prevalent among HIV-infected patients. We examined the association between hepatitis C virus (HCV) co-infection and chronic kidney disease (CKD) among patients initiating modern antiretroviral therapy. METHODS: Data were obtained from the Canadian HIV Observational Cohort for individuals initiating cART from 2000 to 2012. Incident CKD was defined as two consecutive serum creatinine-based estimated glomerular filtration (eGFR) measurements <60 mL/min/1...
April 4, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28362065/alcohol-use-viral-hepatitis-and-liver-fibrosis-among-hiv-positive-persons-in-west-africa-a-cross-sectional-study
#19
Antoine Jaquet, Gilles Wandeler, Marcellin Nouaman, Didier K Ekouevi, Judicaël Tine, Akouda Patassi, Patrick A Coffie, Aristophane Tanon, Moussa Seydi, Alain Attia, François Dabis
INTRODUCTION: Liver fibrosis is often the first stage of liver disease in people living with HIV (PLWHIV) in industrialized countries. However, little is known about liver fibrosis and its correlates among PLWHIV in sub-Saharan Africa. METHODS: The study was undertaken in three HIV referral clinics in Côte d'Ivoire, Senegal and Togo. Enrolled PLWHIV underwent a non-invasive assessment of liver fibrosis combining liver stiffness measure (LSM) with transient elastography and the aspartate aminotransferase-to-platelet ratio index (APRI)...
February 17, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28356465/viral-hepatitis-and-parkinson-disease-a-national-record-linkage-study
#20
Julia Pakpoor, Alastair Noyce, Raph Goldacre, Marianna Selkihova, Stephen Mullin, Anette Schrag, Andrew Lees, Michael Goldacre
OBJECTIVE: To study associations between viral hepatitis and Parkinson disease (PD). METHODS: A retrospective cohort study was done by analyzing linked English National Hospital Episode Statistics and mortality data (1999-2011). Cohorts of individuals with hepatitis B, hepatitis C, autoimmune hepatitis, chronic active hepatitis, and HIV were constructed, and compared to a reference cohort for subsequent rates of PD. RESULTS: The standardized rate ratio (RR) of PD following hepatitis B was 1...
April 25, 2017: Neurology
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