keyword
MENU ▼
Read by QxMD icon Read
search

viral hepatitis b and c, HIV,

keyword
https://www.readbyqxmd.com/read/29143609/survey-of-programmatic-experiences-and-challenges-in-delivery-of-hepatitis-b-and-c-testing-in-low-and-middle-income-countries
#1
Azumi Ishizaki, Julie Bouscaillou, Niklas Luhmann, Stephanie Liu, Raissa Chua, Nick Walsh, Sarah Hess, Elena Ivanova, Teri Roberts, Philippa Easterbrook
BACKGROUND: There have been few reports on programmatic experience of viral hepatitis testing and treatment in resource-limited settings. To inform the development of the 2017 World Health Organization (WHO) viral hepatitis testing guidance and in particular the feasibility of proposed recommendations, we undertook a survey across a range of organisations engaged with hepatitis testing in low- and middle-income countries (LMICs). Our objective was to describe current hepatitis B and C testing practices across a range of settings in different countries, as well as key barriers or challenges encountered and proposed solutions to promote testing scale-up...
November 1, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29132760/hepatitis-c-in-sub-saharan-africa-the-current-status-and-recommendations-for-achieving-elimination-by-2030
#2
REVIEW
Mark W Sonderup, Mary Afihene, Reidwaan Ally, Betty Apica, Yaw Awuku, Lina Cunha, Geoffrey Dusheiko, Neliswa Gogela, Marie-Jeanne Lohouès-Kouacou, Phillip Lam, Olufunmilayo Lesi, Papa Saliou Mbaye, Emmanuel Musabeyezu, Betty Musau, Olesegun Ojo, John Rwegasha, Barbara Scholz, Abate B Shewaye, Christian Tzeuton, Chris Kassianides, C Wendy Spearman
In 2016, WHO adopted a strategy for the elimination of viral hepatitis by 2030. Africa, and more specifically, sub-Saharan Africa, carries a substantial portion of the global burden of viral hepatitis, especially chronic hepatitis B and hepatitis C virus infections. The task that lies ahead for sub-Saharan Africa to achieve elimination is substantial, but not insurmountable. Major developments in the management of hepatitis C have put elimination within reach, but several difficulties will need to be navigated on the path to elimination...
December 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29116878/evaluation-of-methadone-treatment-in-malaysia-findings-from-the-malaysian-methadone-treatment-outcome-study-mytos
#3
Norsiah Ali, Salina Abd Aziz, Salmah Nordin, Norliza Che Mi, Norni Abdullah, V Paranthaman, Maimunah Mahmud, Anne Yee, Mahmoud Danaee
BACKGROUND: Opioid misuse and dependence is a global issue with a huge negative impact. In Malaysia, heroin is still the main illicit drug used, and methadone maintenance treatment (MMT) has been used since 2005. OBJECTIVE: To evaluate the effectiveness of MMT. METHODS: This was a cross-sectional study conducted in 103 treatment centers between October and December 2014 using a set of standard questionnaires. Data were analyzed using SPSS Statistics 20...
November 8, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/29097998/differential-relationships-among-circulating-inflammatory-and-immune-activation-biomediators-and-impact-of-aging-and-human-immunodeficiency-virus-infection-in-a-cohort-of-injection-drug-users
#4
Gregory D Kirk, Stewart Dandorf, Huifen Li, Yiyin Chen, Shruti H Mehta, Damani A Piggott, Joseph B Margolick, Sean X Leng
As individuals with human immunodeficiency virus (HIV) infection live longer, aging and age-related chronic conditions have become major health concerns for this vulnerable population. Substantial evidence suggests that chronic inflammation and immune activation contribute significantly to chronic conditions in people aging with or without HIV infection. As a result, increasing numbers of inflammation and immune activation biomediators have been measured. While very few studies describe their in vivo relationships, such studies can serve as an important and necessary initial step toward delineating the complex network of chronic inflammation and immune activation...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29094807/food-insecurity-may-lead-to-incomplete-hiv-viral-suppression-and-less-immune-reconstitution-among-hiv-hepatitis-c-virus-coinfected-people
#5
W Aibibula, J Cox, A-M Hamelin, Eem Moodie, A I Naimi, T McLinden, M B Klein, P Brassard
OBJECTIVES: The aim of this study was to determine the impact of food insecurity (FI) on HIV viral load and CD4 count among people coinfected with HIV and hepatitis C virus (HCV). METHODS: This study was conducted using data from the Food Security & HIV-HCV Sub-Study of the Canadian Co-Infection Cohort study. FI was measured using the adult scale of Health Canada's Household Food Security Survey Module and was classified into three categories: food security, moderate food insecurity and severe food insecurity...
November 2, 2017: HIV Medicine
https://www.readbyqxmd.com/read/29091279/hbv-hcv-and-hbv-hcv-co-infection-among-hiv-positive-patients-in-hunan-province-china-regimen-selection-hepatotoxicity-and-antiretroviral-therapy-outcome
#6
Shu Su, Christopher Kincaid Fairley, Joe Sasadeusz, Jianmei He, Xiuqing Wei, Huan Zeng, Jun Jing, Limin Mao, Xi Chen, Lei Zhang
Background Co-infection with hepatitis B (HBV) and C (HCV) is common among people living with HIV (PLHIV). This study investigates the impacts of hepatitis co-infection on antiretroviral therapy (ART) outcomes and hepatotoxicity in PLHIV. Methods The cohort study included 1,984 PLHIV. Hepatotoxicity was defined by elevated alanine aminotransferase (ALT) levels. ART outcomes were measured by CD4 cell counts, viral load and mortality rate in patients. Results Among 1,984 PLHIV, 184 (9.3%) were co-infected with HBV and 198 (10...
November 1, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/29033936/coinhibitory-receptor-expression-and-immune-checkpoint-blockade-maintaining-a-balance-in-cd8-t-cell-responses-to-chronic-viral-infections-and-cancer
#7
REVIEW
Isobel S Okoye, Michael Houghton, Lorne Tyrrell, Khaled Barakat, Shokrollah Elahi
In cancer and chronic viral infections, T cells are exposed to persistent antigen stimulation. This results in expression of multiple inhibitory receptors also called "immune checkpoints" by T cells. Although these inhibitory receptors under normal conditions maintain self-tolerance and prevent immunopathology, their sustained expression deteriorates T cell function: a phenomenon called exhaustion. Recent advances in cancer immunotherapy involve blockade of cytotoxic T lymphocyte antigen-4 and programmed cell death 1 in order to reverse T cell exhaustion and reinvigorate immunity, which has translated to dramatic clinical remission in many cases of metastatic melanoma and lung cancer...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29022533/distribution-of-hepatitis-b-virus-infection-in-namibia
#8
P Mhata, T W Rennie, L F Small, P M Nyarang'o, Z Chagla, C J Hunter
BACKGROUND: Namibia regards hepatitis B virus (HBV) infection as a public health problem and introduced hepatitis B vaccinations for infants during 2009. However, information on HBV infection in the country remains limited, and effective public health interventions may be compromised in the absence of adequate evidence-based data. Available data from the World Health Organization (WHO) estimate that 15 - 60% of the normal population in many African countries may be positive for one or more of the HBV serological markers...
September 22, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28994164/utilization-of-increased-risk-for-transmission-of-infectious-disease-donor-organs-in-solid-organ-transplantation-retrospective-analysis-of-disease-transmission-and-safety
#9
Linda Irwin, Camille N Kotton, Nahel Elias, Julie Palafox, Debra Basler, Sarah H Shao, William Lester, Xiaofeng Zhang, Brendan Kimball, Carrie Trencher, Jay A Fishman
The inadequate supply of transplantable organs necessitates new approaches to organ availability. Serologies and nucleic acid testing (NAT) for hepatitis C virus (HCV), hepatitis B virus (HBV), and human immunodeficiency virus (HIV) are used in microbiologic screening of potential organ donors. Organs from donors considered at "high risk" (Centers for Disease Control and Prevention, CDC 1994) or "increased risk" (U.S. Public Health Service, PHS 2013) for transmission of viral infection to recipients may provide an expanded source of organs for transplantation...
October 10, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28991189/translational-implication-of-galectin-9-in-the-pathogenesis-and-treatment-of-viral-infection
#10
REVIEW
Jenn-Haung Lai, Shue-Fen Luo, Mei-Yi Wang, Ling-Jun Ho
The interaction between galectin-9 and its receptor, Tim-3, triggers a series of signaling events that regulate immune responses. The expression of galectin-9 has been shown to be increased in a variety of target cells of many different viruses, such as hepatitis C virus (HCV), hepatitis B virus (HBV), herpes simplex virus (HSV), influenza virus, dengue virus (DENV), and human immunodeficiency virus (HIV). This enhanced expression of galectin-9 following viral infection promotes significant changes in the behaviors of the virus-infected cells, and the resulting events tightly correlate with the immunopathogenesis of the viral disease...
October 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28981470/telomere-dynamics-in-immune-senescence-and-exhaustion-triggered-by-chronic-viral-infection
#11
REVIEW
Marcia Bellon, Christophe Nicot
The progressive loss of immunological memory during aging correlates with a reduced proliferative capacity and shortened telomeres of T cells. Growing evidence suggests that this phenotype is recapitulated during chronic viral infection. The antigenic volume imposed by persistent and latent viruses exposes the immune system to unique challenges that lead to host T-cell exhaustion, characterized by impaired T-cell functions. These dysfunctional memory T cells lack telomerase, the protein capable of extending and stabilizing chromosome ends, imposing constraints on telomere dynamics...
October 5, 2017: Viruses
https://www.readbyqxmd.com/read/28979637/seroprevalence-of-human-immunodeficiency-virus-hepatitis-b-and-c-viruses-among-haemodialysis-patients-in-two-newly-opened-centres-in-cameroon
#12
MULTICENTER STUDY
Henry Namme Luma, Marie Patrice Halle, Servais Albert Fiacre Bagnaka Eloumou, Fondong Azingala, Felicite Kamdem, Olivier Donfack-Sontsa, Gloria Ashuntantang
INTRODUCTION: Haemodialysis (HD) patients are potentially susceptible to infection with blood borne viral agents especially; Human Immunodeficiency Virus (HIV), hepatitis B (HBV) and hepatitis C Viruses (HCV), compared to the general population. We described their epidemiology in two newly created haemodialysis units in Cameroon: the Buea and Bamenda haemodialysis centres. METHODS: A cross sectional study: included were patients who had spent at least three months in haemodialysis...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28965214/serological-and-molecular-markers-of-hepatitis-e-virus-infection-in-hiv-infected-patients-in-brazil
#13
A C Ferreira, Michele Soares Gomes-Gouvêa, G Lisboa-Neto, M C J Mendes-Correa, C M Picone, N A Salles, A Mendrone-Junior, F J Carrilho, J R R Pinho
In Brazil, the circulation of hepatitis E virus (HEV) has been demonstrated in distinct groups of individuals and some animals, but its prevalence among individuals with human immunodeficiency virus (HIV) infection is unknown. This study aimed to assess the frequency of serological and molecular HEV markers in individuals infected with HIV from São Paulo, Brazil. Serum and plasma samples of 354 HIV-infected patients collected between 2007 and 2013 were included. All samples were tested for anti-HEV IgG and IgM antibodies and HEV RNA...
September 30, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28962899/the-interaction-between-mitochondria-and-oncoviruses
#14
REVIEW
Shujie Song, Shasha Gong, Pragya Singh, Jianxin Lyu, Yidong Bai
Mitochondria play important roles in multiple aspects of viral tumorigenesis. Mitochondrial genomes contribute to the host's genetic background. After viruses enter the cell, they modulate mitochondrial function and thus alter bioenergetics and retrograde signaling pathways. At the same time, mitochondria also regulate and mediate viral oncogenesis. In this context, oncogenesis by oncoviruses like Hepatitis B virus (HBV), Hepatitis C virus (HCV), Human papilloma virus (HPV), Human Immunodeficiency virus (HIV) and Epstein-Barr virus (EBV) will be discussed...
September 26, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28954067/profile-of-hiv-subtypes-in-hiv-hbv-and-hiv-hcv-coinfected-patients-in-southern-brazil
#15
Valéria Miranda Avanzi, Bianca Arão Vicente, Nayara Carvalho Polido Beloto, Monica Maria Gomes-da-Silva, Clea Elisa Lopes Ribeiro, Felipe Francisco Tuon, Luine Rosele Renaud Vidal, Meri Bordignon Nogueira, Sonia Mara Raboni
INTRODUCTION: HIV and viral hepatitis infections are major causes of chronic disease worldwide and have some similarities with regard to routes of transmission, epidemiology, front barriers faced during access of treatment, and strategies for a global public health response. The objective was to describe the HIV-1 subtypes, viral tropism and single-nucleotide polymorphisms (SNPs) of interleukin 28B (IL28B) from a case series of HIV/viral hepatitis coinfected patients from southern Brazil...
July 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28953324/clinical-utility-of-hcv-core-antigen-detection-and-quantification-using-serum-samples-and-dried-blood-spots-in-people-who-inject-drugs-in-dar-es-salaam-tanzania
#16
Zameer Mohamed, Jessie Mbwambo, Yusuke Shimakawa, Lila Poiteau, Stéphane Chevaliez, Jean-Michel Pawlotsky, John Rwegasha, Sanjay Bhagani, Taylor-Robinson Simon D, Julie Makani, Mark R Thursz, Maud Lemoine
INTRODUCTION: A lack of access to hepatitis C virus (HCV) diagnostics is a significant barrier to achieving the World Health Organization 2030 global elimination goal. HCV core antigen (HCVcAg) quantification and dried blood spot (DBS) are appealing alternatives to conventional HCV serology and nucleic acid testing (NAT) for resource-constraint settings, particularly in difficult-to-reach populations. We assessed the accuracy of serum and DBS HCVcAg testing in people who inject drugs in Tanzania using HCV NAT as a reference...
September 19, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28951598/prevalence-and-predictors-of-liver-disease-in-hiv-infected-children-and-adolescents
#17
Maria Pokorska-Śpiewak, Aleksandra Stańska-Perka, Jolanta Popielska, Agnieszka Ołdakowska, Urszula Coupland, Konrad Zawadka, Małgorzata Szczepańska-Putz, Magdalena Marczyńska
Liver disease in HIV-infected patients may result from the infection itself, antiretroviral treatment or comorbidities. In this study, we analysed liver disease in 79 HIV-infected children and adolescents aged 14.0 ± 5.1 years. All the patients were receiving combination antiretroviral therapy (cART), with a mean duration of 11.5 ± 4.7 years. Six patients (8%) had detectable HIV viral load, and 8/79 (10%) of the participants were coinfected with hepatitis B or C virus (HCV, 6/8 or HBV, 2/8). Liver disease was defined as an elevation of any of the following parameters: alanine or aspartate aminotransferase (ALT and AST), total bilirubin, and gamma glutamyl transferase (GGTP)...
September 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28949020/barriers-to-hepatitis-c-treatment-in-the-era-of-direct-acting-anti-viral-agents
#18
M Lin, J Kramer, D White, Y Cao, S Tavakoli-Tabasi, S Madu, D Smith, S M Asch, H B El-Serag, F Kanwal
BACKGROUND: Direct-acting anti-virals (DAA) are safe, effective treatment of hepatitis C virus (HCV). Suboptimal linkage to specialists and access to DAAs are the leading barriers to treatment; however, data are limited. AIM: To determine predictors of follow-up, receipt of DAAs, and reasons for the lack thereof. METHODS: We used clinical data from retrospective cohort of HCV-infected patients with previously established HCV care in the US Department of Veterans Affairs to examine predictors of follow-up in HCV clinics and DAA treatment (during 12/1/2013-4/30/2015)...
September 26, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28947403/hepatitis%C3%A2-b-c-and-e-infection-among-hiv-infected-patients-in-franceville-gabon-retrospective-cross-sectional-study
#19
B Bivigou-Mboumba, F Rouet, A Mouinga-Ondeme, L Deleplancque, J Sica, A Ndjoyi-Mbiguino, R Njouom, S François-Souquière
Access to antiretrovirals has increased the life expectancy of patients living with HIV. However, HIV-viral hepatitis coinfections in countries endemic for these infections make management more difficult. To determine the extent of these coinfections in Gabon, we investigated markers of hepatitis B, C, and E viruses in 762 adults infected with HIV-1 by ELISA. We used real-time PCR to quantify plasma HBV DNA (HBV VL) and amplified HCV and HEV RNA by nested RT-PCR and PCR.The seroprevalence of chronic hepatitis B infection was 9...
August 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28945149/risk-of-developing-antiphospholipid-antibodies-following-viral-infection-a-systematic-review-and-meta-analysis
#20
N Abdel-Wahab, S Talathi, M A Lopez-Olivo, M E Suarez-Almazor
Objective The objective of this paper is to conduct a systematic review and meta-analysis on the risk of developing elevated antiphospholipid (aPL) antibodies and related thromboembolic and/or pregnancy events following a viral infection. Method We searched Medline, EMBASE, Web of Science, PubMed ePubs, and Cochrane Central Register of Controlled Trials through June 2016. Independent observational studies of elevated aPL antibodies in patients with a viral infection compared with controls or patients with lupus were included...
January 1, 2017: Lupus
keyword
keyword
35133
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"