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Bamidele O Johnson, Amisha Nimawat, Nyier W Doar, Thi Nguyen, Malar Thwin
Immune thrombocytopenic purpura (ITP) is a hematologic condition characterized by decreased circulating platelets, resulting in bruising, bleeding gums, and internal bleeding. This disorder can be categorized into two primary forms based on the duration of symptoms and underlying causes. Acute ITP primarily affects young children, typically between the ages of two and six, but it can also impact older children and adults. Viral infections like chickenpox, respiratory infections, or gastroenteritis often precede it...
March 2024: Curēus
#2
JOURNAL ARTICLE
Carolin Zitzmann, Ruian Ke, Ruy M Ribeiro, Alan S Perelson
Mathematical models of viral infection have been developed, fitted to data, and provide insight into disease pathogenesis for multiple agents that cause chronic infection, including HIV, hepatitis C, and B virus. However, for agents that cause acute infections or during the acute stage of agents that cause chronic infections, viral load data are often collected after symptoms develop, usually around or after the peak viral load. Consequently, we frequently lack data in the initial phase of viral growth, i.e...
April 16, 2024: PLoS Computational Biology
#3
JOURNAL ARTICLE
Waleed Abdelgaber Nemr, Radwan K Nashwa
BACKGROUND: Hepatitis C virus (HCV), hepatitis B virus (HBV), and human immunodeficiency virus 1 (HIV-1) are the most epidemic blood-borne viruses, posing threats to human health and causing economic losses to nations for combating the infection transmission. The diagnostic methodologies that depend on the detection of viral nucleic acids are much more expensive, but they are more accurate than serological testing. AIM: To develop a rapid, cost-effective, and accurate diagnostic multiplex polymerase chain reaction (PCR) assay for simultaneous detection of HCV, HBV, and HIV-1...
March 25, 2024: World Journal of Virology
#4
JOURNAL ARTICLE
Fadia M Attia, Ahmed M Farouk, Shaymaa A Abdelhady
Prevention of transfusion-transmitted viral infections and insurance of safe blood transfusion are the main goals of all blood banks worldwide. Despite the high sensitivity and specificity of currently used enzyme linked immunosorbent assay (ELISA) for hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) testing, viral transmission could still occur during the window period. Introducing viral individual donation nucleic acid testing (ID-NAT) can greatly decrease such risk providing an additional layer in securing blood transfusion...
April 2024: Egyptian Journal of Immunology
#5
JOURNAL ARTICLE
Murad A Mubaraki, Mubbashir Hussain, Fozia Fozia, Ijaz Ahmad, Shahid Niaz Khan, Abdul Qadir Khan, Ziaullah Ziaullah
INTRODUCTION: This study determines the incidence of common viral and helminth coinfections with malaria in the tertiary care hospital set up in southern Khyber Pakhtunkhwa, Pakistan. MATERIALS AND METHODS: The multidimensional research included malaria patients admitted to different hospitals of district Kohat during January and December 2021. Stool samples and blood were assembled from the patients. Giemsa-stained microscopy-positive samples were processed by the immunochromatography technique (ICT) to identify Plasmodium species...
2024: Journal of Tropical Medicine
#6
REVIEW
Arian Haghtalab, Milad Hejazi, Naeem Goharnia, Ali Yekanlou, Kousha Hazhir, Asma Barghi, Zahra Bazzaz, Iman Allahverdizadeh, Ataollah GhalibafSabbaghi
Extensive research has been conducted on the correlation between viral infections and hematological cancers ever since the identification of the Rous Sarcoma Virus as a cancer-causing agent. Numerous viruses, such as the Epstein-Barr virus, hepatitis B virus, hepatitis C virus, human immunodeficiency virus, human T-lymphotropic virus 1, and severe acute respiratory syndrome-related coronavirus 2, have been identified as potential contributors to the development and progression of cancer by disrupting normal cellular processes...
March 28, 2024: Medical Oncology
#7
JOURNAL ARTICLE
Jaisheela Vimali, Yean K Yong, Amudhan Murugesan, Hong Y Tan, Ying Zhang, Rajeev Ashwin, Sivadoss Raju, Pachamuthu Balakrishnan, Marie Larsson, Vijayakumar Velu, Esaki M Shankar
BACKGROUND: Chronic viral infection results in impaired immune responses rendering viral persistence. Here, we compared the quality of T-cell responses among chronic hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV)-infected individuals by examining the levels of expression of selected immune activation and exhaustion molecules on circulating MAIT cells and Tfh cells. METHODS: Cytokines were measured using a commercial Bio-plex Pro Human Cytokine Grp I Panel 17-plex kit (BioRad, Hercules, CA, USA)...
March 22, 2024: Frontiers in Bioscience (Landmark Edition)
#8
JOURNAL ARTICLE
Camila A Picchio, Aina Nicolàs, Ironne Valdèse Ayemfouo Fofou, Viola Kasone, Magellan Guewo-Fokeng, Claude T Tagny, Teddy Nanyonjo, Hellen Nansumba, Yves Nacel Kouongni, Rita Gaëlle Epse Sezawo Kamdjeu, Emmanuel Seremba, Charles Kouanfack, Isaac Ssewanyana, Richard Njouom, Ariadna Rando Segura, Francisco Rodríguez-Frías, Jean Claude Mbanya, Ponsiano Ocama, Jeffrey V Lazarus
BACKGROUND: Sub-Saharan African countries have a high burden of viral hepatitis and poor access to screening and care. The aim of this study was to evaluate the feasibility and acceptability of using the plasma separation card (PSC) for viral hepatitis B and C screening among people living with HIV (PLHIV) in Cameroon and Uganda. METHODS: This is a cross-sectional study carried out between 05/2021 and 03/2023 including 192 PLHIV in Cameroon (n = 104) and Uganda (n = 88)...
March 27, 2024: Journal of Epidemiology and Global Health
#9
JOURNAL ARTICLE
Soe T Maung, Pakanat Decharatanachart, Sombat Treeprasertsuk, Roongruedee Chaiteerakij
BACKGROUND AND AIMS: Chronic viral hepatitis B (CHB)-infected patients occasionally develop cirrhosis despite having persistent viral suppression with antiviral therapy. We aimed to identify risk factors for developing cirrhosis in hepatitis B virus (HBV)-suppressed patients. METHODS: We conducted a case-control study involving 120 noncirrhotic CHB-infected patients achieving viral suppression with antiviral treatment, with 40 cases developing cirrhosis and 80 age-, sex-, and Fibrosis-4 (FIB-4)-matched controls...
2024: Journal of Clinical and Experimental Hepatology
#10
JOURNAL ARTICLE
Helen M Faddy, Carla Osiowy, Brian Custer, Michael Busch, Susan L Stramer, Melinda M Dean, Jessika Acutt, Elvina Viennet, Thijs van de Laar, Wai-Chiu Tsoi, Claire Styles, Phil Kiely, Angelo Margaritis, So-Yong Kwon, Yan Qiu, Xuelian Deng, Antoine Lewin, Signe Winther Jørgensen, Christian Erikstrup, David Juhl, Silvia Sauleda, Bernardo Armando Camacho Rodriguez, Lisbeth Jennifer Catherine Soto Coral, Paula Andrea Gaviria García, Sineenart Oota, Sheila F O'Brien, Silvano Wendel, Emma Castro, Laura Navarro Pérez, Heli Harvala, Katy Davison, Claire Reynolds, Lisa Jarvis, Piotr Grabarczyk, Aneta Kopacz, Magdalena Łętowska, Niamh O'Flaherty, Fiona Young, Padraig Williams, Lisa Burke, Sze Sze Chua, An Muylaert, Isabel Page, Ann Jones, Christoph Niederhauser, Marion Vermeulen, Syria Laperche, Pierre Gallian, Masahiro Satake, Marcelo Addas-Carvalho, Sebastián Blanco, Sandra V Gallego, Axel Seltsam, Marijke Weber-Schehl, Arwa Z Al-Riyami, Khuloud Al Maamari, Fatma Ba Alawi, Hem Chandra Pandey, Rochele Azevedo França, Richard Charlewood
BACKGROUND AND OBJECTIVES: Nucleic acid-amplification testing (NAT) is used for screening blood donations/donors for blood-borne viruses. We reviewed global viral NAT characteristics and NAT-yield confirmatory testing used by blood operators. MATERIALS AND METHODS: NAT characteristics and NAT-yield confirmatory testing used during 2019 was surveyed internationally by the International Society of Blood Transfusion Working Party Transfusion-Transmitted Infectious Diseases...
March 22, 2024: Vox Sanguinis
#11
REVIEW
Marcos Vinicius de Sousa
Glomeruli can be damaged in several conditions after kidney transplantation, with a potential impact on the graft function and survival. Primary glomerulonephritis, a group of glomerular immunological damage that results in variable histological patterns and clinical phenotypes, can occur in kidney transplant recipients as a recurrent or de novo condition. Specific immunologic conditions associated with kidney transplantation, such as acute rejection episodes, can act as an additional trigger after transplantation, impacting the incidence of these glomerulopathies...
2024: International Journal of Nephrology and Renovascular Disease
#12
JOURNAL ARTICLE
Keyur Patel, Sumeet K Asrani, Maria Isabel Fiel, Deborah Levine, Daniel H Leung, Andres Duarte-Rojo, Jonathan A Dranoff, Tarek Nayfeh, Bashar Hasan, Tamar H Taddei, Yahya Alsawaf, Samer Saadi, Abdul Mounaem Majzoub, Apostolos Manolopoulos, Muayad Alzuabi, Jingyi Ding, Nigar Sofiyeva, M Hassan Murad, Mouaz Alsawas, Don C Rockey, Richard K Sterling
BACKGROUND AND AIMS: Blood-based biomarkers have been proposed as an alternative to liver biopsy for non-invasive liver disease assessment (NILDA) in chronic liver disease (CLD). Our aims for this systematic review were to evaluate the diagnostic utility of selected blood-based tests either alone, or in combination, for identifying significant fibrosis (F2-4), advanced fibrosis (F3-4) and cirrhosis (F4), as compared to biopsy in CLD. APPROACH AND RESULTS: We included a comprehensive search of databases including Ovid MEDLINE(R), EMBASE, Cochrane Database, and Scopus through to April 2022...
March 15, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
#13
JOURNAL ARTICLE
Amrei Krings, Gyde Steffen, Ruth Zimmermann
BACKGROUND: To reach the global elimination goals of viral hepatitis B and C (HBC, HCV), human immunodeficiency virus (HIV) and other sexually transmitted infections as a public health threat by 2030, monitoring is needed. Staff members of drug services and opioid substitution treatment (OST) practices in Berlin and Bavaria recruited clients for a pilot study addressing the respective infections among people who injected drugs (PWID) in Germany, 2021/2022. Participants filled a questionnaire and were tested for HBV, HCV, HIV and syphilis using dried blood spots (DBS)...
March 14, 2024: Harm Reduction Journal
#14
JOURNAL ARTICLE
Jehan Altinawe, Muhammad Eid Akkawi, Nihad Kharrat Helu, Qusai Hassan, Abdul-Hakim Nattouf
OBJECTIVE: The aim of this study is to determine the prevalence rates of hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) infections among hemodialysis (HD) patients as well as to identify associated risk factors. METHODOLOGY: A multicenter cross-sectional study involved patients who had been on HD for at least three months. The study was conducted at five HD centers in Damascus, Syria from August 2019 to September 2021. HBsAg, HCV-Ab and HIV (antibody/antigen) seropositivity were identified using the third generation ELISA technique...
March 6, 2024: BMC Infectious Diseases
#15
JOURNAL ARTICLE
Danish Kumar, Raja Taha Yaseen, Muhammad Qaiser Panezai, Muhammad Usman Naeem, Hina Ismail, Zain Majid, Nasir Mehmood, Muhammad Ali Khalid, Ghulamullah Lail, Nasir Hassan Luck
Introduction Limited studies are available for predicting mortality in patients with spontaneous bacterial peritonitis (SBP) based on ascitic fluid analysis. Recently, a proposition has been made regarding the role of ascitic fluid lactate as a better prognostic indicator of mortality in cirrhotic patients with SBP. Therefore, we aimed to evaluate the utility of ascitic fluid lactate in predicting mortality in cirrhotic patients with SBP. Methods This was a prospective, observational study that was conducted in the Hepato-Gastroenterology Department of Sindh Institute of Urology and Transplantation (SIUT), Karachi from 1 January 2022 to 31 December 2022...
January 2024: Curēus
#16
JOURNAL ARTICLE
Naomi Beard, Michael McGrath, Debbie Scott, Ziad Nehme, Dan I Lubman, Rowan P Ogeil
OBJECTIVE: Preventable transmission of blood-borne viruses (BBV), including human immunodeficiency virus (HIV), hepatitis C virus (HCV) and hepatitis B virus (HBV), continue in at-risk populations, including people who use alcohol and drugs (AODs). To our knowledge, no studies have explored the use of ambulance data for surveillance of AOD harms in patients with BBV infections. METHODS: We used electronic patient care records from the National Ambulance Surveillance System for people who were attended by an ambulance in Victoria, Australia between July 2015 and July 2016 for AOD-related harms, and with identified history of a BBV infection...
February 28, 2024: Emergency Medicine Australasia: EMA
#17
JOURNAL ARTICLE
Inas Muayad Mohammed Ali, Ashwaq Ali Hussein, Israa Mustafa Salih Al-Musawi, Sabeeha Sahib Hadi Hillawi, Naus Salih Kadhim, Abdulkareem Alaiwi Jasim
Hemophilia is an X-linked congenital bleeding disorder caused by a deficiency of coagulation factor VIII (FVIII) (in hemophilia A) or factor IX (FIX) (in hemophilia B) and is one of the most important hereditary conditions in Iraq. The current study tried to provide a glimpse into the epidemiological and clinical status, as well as complications and treatment used for patients with hemophilia A in Karbala, Iraq. This retrospective research was carried out by reviewing the medical records of 90 male patients diagnosed with hemophilia A registered at the Hereditary Blood Disease Center in Karbala Teaching Hospital for children in Karbala, Iraq...
November 2023: Journal of Medicine and Life
#18
Proteomic Signature of HIV-Associated Subclinical Left Atrial Remodeling and Incident Heart Failure.
Tess E Peterson, Virginia S Hahn, Ruin Moaddel, Min Zhu, Sabina A Haberlen, Frank J Palella, Michael Plankey, Joel S Bader, Joao Ac Lima, Robert E Gerszten, Jerome I Rotter, Stephen S Rich, Susan R Heckbert, Gregory D Kirk, Damani A Piggott, Luigi Ferrucci, Joseph B Margolick, Todd T Brown, Katherine C Wu, Wendy S Post
BACKGROUND: People living with HIV (PLWH) are at higher risk of heart failure (HF) and preceding subclinical cardiac abnormalities, including left atrial dilation, compared to people without HIV (PWOH). Hypothesized mechanisms include premature aging linked to chronic immune activation. We leveraged plasma proteomics to identify potential novel contributors to HIV-associated differences in indexed left atrial volume (LAVi) among PLWH and PWOH and externally validated identified proteomic signatures with incident HF among a cohort of older PWOH...
February 14, 2024: medRxiv
#19
JOURNAL ARTICLE
Helen M Faddy, Carla Osiowy, Brian Custer, Michael Busch, Susan L Stramer, Opeyemi Adesina, Thijs van de Laar, Wai-Chiu Tsoi, Claire Styles, Phil Kiely, Angelo Margaritis, So-Yong Kwon, Yan Qiu, Xuelian Deng, Antoine Lewin, Signe Winther Jørgensen, Christian Erikstrup, David Juhl, Silvia Sauleda, Bernardo Armando Camacho Rodriguez, Lisbeth Jennifer Catherine Soto Coral, Paula Andrea Gaviria García, Sineenart Oota, Sheila F O'Brien, Silvano Wendel, Emma Castro, Laura Navarro Pérez, Heli Harvala, Katy Davison, Claire Reynolds, Lisa Jarvis, Piotr Grabarczyk, Aneta Kopacz, Magdalena Łętowska, Niamh O'Flaherty, Fiona Young, Padraig Williams, Lisa Burke, Sze Sze Chua, An Muylaert, Isabel Page, Ann Jones, Christoph Niederhauser, Marion Vermeulen, Syria Laperche, Pierre Gallian, Salam Sawadogo, Masahiro Satake, Ahmad Gharehbaghian, Marcelo Addas-Carvalho, Sebastián Blanco, Sandra V Gallego, Axel Seltsam, Marijke Weber-Schehl, Arwa Z Al-Riyami, Khuloud Al Maamari, Fatma Ba Alawi, Hem Chandra Pandey, Dora Mbanya, Rochele Azevedo França, Richard Charlewood
BACKGROUND AND OBJECTIVES: Nucleic acid amplification testing (NAT), in blood services context, is used for the detection of viral and parasite nucleic acids to reduce transfusion-transmitted infections. This project reviewed NAT for screening blood donations globally. MATERIALS AND METHODS: A survey on NAT usage, developed by the International Society of Blood Transfusion Working Party on Transfusion-transmitted Infectious Diseases (ISBT WP-TTID), was distributed through ISBT WP-TTID members...
February 23, 2024: Vox Sanguinis
#20
JOURNAL ARTICLE
Foulques Icole, Vincent Haghnejad, Cyrille Jeannoel, Philippe Besançon, Frédéric Boulanger, Jean-Pierre Bronowicki
INTRODUCTION: Several studies suggest that the prevalence of hepatitis C, hepatitis B and HIV are higher in psychiatric patients than in the general population; however, few French studies have been published. The aims of this study were to determine the seroprevalence of the three viruses, describe the profile of infected patients and evaluate the initiation of antiviral treatment in a population of patients hospitalized in a psychiatric hospital. METHOD: Between January and October 2020, screening for hepatitis C virus, hepatitis B virus and HIV was systematically offered to all patients admitted to the intersectoral reception and orientation unit of a psychiatric hospital...
February 16, 2024: L'Encéphale
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