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sufentanil butorphanol

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https://www.readbyqxmd.com/read/25972155/intranasal-administration-of-butorphanol-benefits-old-patients-undergoing-h-uvulopalatopharyngoplasty-a-randomized-trial
#1
RANDOMIZED CONTROLLED TRIAL
Lin Yang, De-feng Sun, Yue Wu, Jun Han, Ruo-chuan Liu, Li-jie Wang
BACKGROUND: To evaluate intranasal administration of butorphanol on postoperative pain and early postoperative cognitive dysfunction in old patients undergoing H-uvulopalatopharyngoplasty (H-UPPP). METHODS: A total of 260 male patients (65 to 77 years old) with obstructive sleep apnea hypopnea syndrome and scheduled for H-UPPP were divided randomly to receive intranasal butorphanol, intravenous butorphanol, intranasal fentanyl, or intravenous saline (controls). The definition of preemptive analgesia is that the tested drugs are given before anesthesia induction...
2015: BMC Anesthesiology
https://www.readbyqxmd.com/read/25972091/opioids-for-agitation-in-dementia
#2
REVIEW
Richard Brown, Robert Howard, Bridget Candy, Elizabeth L Sampson
BACKGROUND: Agitation is a common experience for people living with dementia, particularly as day-to-day function and cognition start to decline more. At the present time there are limited pharmacological options for relieving agitation and little is known about the safety and efficacy of opioid drugs in this setting. OBJECTIVES: To determine the clinical efficacy and safety of opioids for agitation in people with dementia. SEARCH METHODS: We searched ALOIS, the Cochrane Dementia and Cognitive Improvement Group Specialized Register, on 13 June 2014 using the terms: narcotic OR opioid OR opium OR morphine OR buprenorphine OR codeine OR dextromoramide OR diphenoxylate OR dipipanone OR dextropropoxyphene OR propoxyphene OR diamorphine OR dihydrocodeine OR alfentanil OR fentanyl OR remifentanil OR meptazinol OR methadone OR nalbuphine OR oxycodone OR papaveretum OR pentazocine OR meperidine OR pethidine OR phenazocine OR hydrocodone OR hydromorphone OR levorphanol OR oxymorphone OR butorphanol OR dezocine OR sufentanil OR ketobemidone...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/24984895/partial-intravenous-anaesthesia-in-the-horse-a-review-of-intravenous-agents-used-to-supplement-equine-inhalation-anaesthesia-part-2-opioids-and-alpha-2-adrenoceptor-agonists
#3
REVIEW
Miguel Gozalo-Marcilla, Frank Gasthuys, Stijn Schauvliege
OBJECTIVE: To review the literature with regard to the use of different intravenous agents as supplements to inhalational anaesthesia in horses. The Part 2 of this review will focus in the use of opioids and α2 -agonists. DATABASES USED: Pubmed and Web of Science. Search terms: horse, inhalant anaesthesia, balanced anaesthesia, partial intravenous anaesthesia, opioids, morphine, pethidine, butorphanol, methadone, fentanyl, alfentanil, remifentanil, sufentanil, xylazine, romifidine, detomidine, medetomidine and dexmedetomidine...
January 2015: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/22931048/the-toxic-effect-of-opioid-analgesics-on-human-sperm-motility-in-vitro
#4
Bo Xu, Zhi-Ping Wang, Yan-Juan Wang, Pei-Hua Lu, Li-Jun Wang, Xiao-Hai Wang
Opioid analgesics are the most common therapeutic analgesic for acute pain. In this study, the toxicological and pharmacological features of a group of opioid analgesics were characterized by the motility of human sperm. Aliquots of sperm were incubated with various concentrations of opioid analgesics in vitro. Computer-assisted sperm analysis was used to assess sperm motility at 15 minutes, 2 hours, and 4 hours after drug addition to the medium. Butorphanol and dezocine showed marked reduction of motility after incubation with sperm for 15 minutes...
April 2013: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/22295851/-effects-of-opioid-analgesics-on-sperm-motility-in-vitro
#5
Bo Xu, Zhi-ping Wang, Yan-juan Wang, Yi-ping Hu, Li-jun Wang, Xiao-hai Wang
OBJECTIVE: To observe the effects of short-term exposure to opioid analgesics on human sperm motility. METHODS: Twenty normal semen samples were collected, each divided into 19 groups, one as the control and the others treated in vitro with six opioid analgesics at three different concentrations, respectively, and sperm motility was assessed by computer-assisted sperm analysis at 15 min, 2 h and 4 h. RESULTS: Compared with the control group, fentanyl, alfentanil and sufentanil at 1 x 10(-5), 2 x 10(-3) and 0...
January 2012: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/21804804/a-comparative-evaluation-of-intrathecal-bupivacaine-alone-sufentanil-or-butorphanol-in-combination-with-bupivacaine-for-endoscopic-urological-surgery
#6
Manpreet Kaur, Sunil Katyal, Suneet Kathuria, Prabhjot Singh
BACKGROUND: The objective of the present study was to compare the onset, degree and recovery time of sensory and motor block and hemodynamic effects of intrathecal bupivacaine alone and bupivacaine with sufentanil or butorphanol in endoscopic urological surgeries. METHODS: In a randomized, double-blind study, 90 patients of either sex and age, belonging to ASA Grades I and II, scheduled for elective endoscopic urological surgeries under spinal anesthesia, were allocated into three groups of 30 each...
April 2011: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/21215785/uniform-assessment-and-ranking-of-opioid-%C3%AE-receptor-binding-constants-for-selected-opioid-drugs
#7
COMPARATIVE STUDY
Donna A Volpe, Grainne A McMahon Tobin, R Daniel Mellon, Aspandiar G Katki, Robert J Parker, Thomas Colatsky, Timothy J Kropp, S Leigh Verbois
The safe disposal of unused opioid drugs is an area of regulatory concern. While toilet flushing is recommended for some drugs to prevent accidental exposure, there is a need for data that can support a more consistent disposal policy based on an assessment of relative risk. For drugs acting at the Mu-opioid receptor (MOR), published measurements of binding affinity (K(i)) are incomplete and inconsistent due to differences in methodology and assay system, leading to a wide range of values for the same drug thus precluding a simple and meaningful relative ranking of drug potency...
April 2011: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/19469098/-new-opioids-for-general-anaesthesia-and-in-and-out-hospital-analgesia
#8
REVIEW
Iwona Dabrowska-Wójciak, Andrzej Piotrowski
Over the last 30 years, three new opioids of the piperidine family have been introduced to anaesthesia clinical practice: sufentanil, alfentanil and remifentanil. Alfentanil is a derivative of fentanyl, with quicker onset than that of fentanyl and with shorter duration and more intense vagomimetic properties than those of fentanyl and sufentanil. It may cause less intense respiratory depression than equianalgesic doses of fentanyl. Clinical trials indicate that alfentanil can be used effectively as an analgesic, as an analgesic supplement to anaesthesia, and as the major component of a general anaesthetic...
January 2008: Anestezjologia Intensywna Terapia
https://www.readbyqxmd.com/read/18467078/pharmacokinetic-pharmacodynamic-modelling-of-the-eeg-effects-of-opioids-the-role-of-complex-biophase-distribution-kinetics
#9
Dorien Groenendaal, Jan Freijer, Andrea Rosier, Dennis de Mik, Glynis Nicholls, Anne Hersey, Andrew D Ayrton, Meindert Danhof, Elizabeth C M de Lange
The objective of this investigation is to characterize the role of complex biophase distribution kinetics in the pharmacokinetic-pharmacodynamic correlation of a wide range of opioids. Following intravenous infusion of morphine, alfentanil, fentanyl, sufentanil, butorphanol and nalbuphine the time course of the EEG effect was determined in conjunction with blood concentrations. Different biophase distribution models were tested for their ability to describe hysteresis between blood concentration and effect...
July 3, 2008: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/12139528/nasal-administration-of-opioids-for-pain-management-in-adults
#10
REVIEW
O Dale, R Hjortkjaer, E D Kharasch
BACKGROUND: Nasal administration of opioids may be an alternative route to intravenous, subcutaneous, oral transmucosal, oral or rectal administration in some patients. Key features may be self-administration, combined with rapid onset of action. The aim of this paper is to evaluate the present base of knowledge on this topic. METHODS: The review is based on human studies found in Medline or in the reference list of these papers. The physiology of the nasal mucosa and some pharmaceutical aspects of nasal administration are described...
August 2002: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/12092171/-opioid-tolerance-and-dependence-pharmacological-aspects
#11
REVIEW
I M Jaba, I Luncanu, O C Mungiu
Prolonged opioids administration leads inevitably to tolerance and dependence, a phenomenon we meet more often in healthy people than in ill patients. Tolerance means a hypersensibility of neuronal membranes as well as changes in the number and affinity of opioid receptors, which implies intake of larger doses to obtain the initial effect. Physical dependence, quite different of the psychological one, is the appearance of abstinence syndrome on sudden interruption of opioid administration or on administration of an antagonist...
July 2001: Revista Medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti Din Iaş̧i
https://www.readbyqxmd.com/read/11037117/sufentanil-and-medetomidine-anaesthesia-in-the-rat-and-its-reversal-with-atipamezole-and-butorphanol
#12
COMPARATIVE STUDY
P Hedenqvist, J V Roughan, P A Flecknell
Injectable anaesthetics are widely used to anaesthetize rats, but recovery times are often prolonged. Reversible anaesthetic regimens have the advantage that animals may be recovered quickly, thus reducing the incidence of postoperative complications such as hypothermia, and also providing a means of treating inadvertent anaesthetic overdose. This study assessed and compared the characteristics of anaesthesia induced with combinations of sufentanil and medetomidine administered as a single subcutaneous or intraperitoneal dose, and reversal with butorphanol and atipamezole...
July 2000: Laboratory Animals
https://www.readbyqxmd.com/read/10386982/membrane-microviscosity-modulates-mu-opioid-receptor-conformational-transitions-and-agonist-efficacy
#13
P J Emmerson, M J Clark, F Medzihradsky, A E Remmers
The influence of membrane microviscosity on mu-opioid agonist and antagonist binding, as well as agonist efficacy, was examined in membranes prepared from SH-SY5Y cells and from a C6 glioma cell line stably expressing the rat mu-opioid receptor (C6mu). Addition of cholesteryl hemisuccinate (CHS) to cell membranes increased membrane microviscosity and reduced the inhibitory effect of sodium and guanine nucleotides on the affinity of the full agonists sufentanil and [D-Ala2,N-MePhe4,Gly-ol5]enkephalin (DAMGO) for the mu-opioid receptor...
July 1999: Journal of Neurochemistry
https://www.readbyqxmd.com/read/9862403/tolerance-and-cross-tolerance-to-the-rate-suppressing-effects-of-opioids-in-butorphanol-treated-rats-influence-of-maintenance-dose-and-relative-efficacy-at-the-mu-receptor
#14
M A Smith, M J Picker
The purpose of the present investigation was to examine the development of tolerance to the rate-suppressing effects of mu and kappa opioids in rats administered either 3.0 (low) or 30 (high) mg/kg per day of butorphanol, an opioid with low relative efficacy at the mu receptor. The mu opioids butorphanol, buprenorphine, morphine, fentanyl and sufentanil, and the kappa opioid U50,488 dose-dependently suppressed responding under all conditions examined. In rats administered the low maintenance dose of butorphanol, tolerance developed to the effects of butorphanol, buprenorphine and morphine, but not to fentanyl and sufentanil...
November 1998: Psychopharmacology
https://www.readbyqxmd.com/read/9722054/the-effects-of-epidural-opioids-on-fetal-heart-rate-variability-when-coadministered-with-0-25-bupivacaine-for-labor-analgesia
#15
RANDOMIZED CONTROLLED TRIAL
M S St Amant, B Koffel, A M Malinow
Assessment of fetal heart rate (FHR) variability provides important information regarding fetal well-being. Normal FHR variability is generally associated with fetal normoxia. Opioids are frequently co-administered with local anesthetics to provide epidural analgesia for labor. Epidural opioid effects on FHR variability have not been extensively studied. In a double-blind, randomized study, 109 parturients had their epidural catheter injected with either butorphanol (2 mg), fentanyl (50 microg), sufentanil (15 microg) or saline and bupivacaine (0...
June 1998: American Journal of Perinatology
https://www.readbyqxmd.com/read/8819494/characterization-of-opioid-agonist-efficacy-in-a-c6-glioma-cell-line-expressing-the-mu-opioid-receptor
#16
P J Emmerson, M J Clark, A Mansour, H Akil, J H Woods, F Medzihradsky
In C6 glioma cells stably expressing a homogeneous population of the cloned rat mu opioid receptor, the binding affinities of opioid agonists and subsequent activation of G protein were examined. Opioid receptor number in membranes of these cells was high (10-30 pmol/mg protein [3H]diprenorphine binding sites). Opioids were found to bind to the receptor with high affinity [Tyr-D-Ala-Gly-(Me)Phe-Gly-ol (DAMGO) 0.23 nM; sufentanil 0.034 nM; morphine 0.16 nM]. Activation of G protein by opioid agonists was examined by measuring the stimulation of guanosine-5'-O-(3-[35S]thio)triphosphate ([35S]GTP gamma S) binding...
September 1996: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/8526956/-treatment-of-postoperative-pain-with-peridural-administration-of-opioids
#17
REVIEW
S Chrubasik, J Chrubasik
The advantages and disadvantages associated with epidural opioids require careful selection of the opioid and its dose regimen. There is no ideal opioid available for epidural use. Comparative pharmacokinetic data help selection of the appropriate epidural opioid. Morphine (provided it is given in small doses and volumes) is very appropriate for epidural pain treatment, especially for longer periods of treatment, due to the excellent analgesia and very low systemic morphine concentrations. The faster onset of analgesia makes the epidural application of pethidine, alfentanil and fentanyl recommendable...
1995: Anaesthesiologie und Reanimation
https://www.readbyqxmd.com/read/6232405/-new-anesthetics-and-development-of-methods-of-anesthesia-part-1
#18
REVIEW
M Miyazaki, K Yoda, C Okuda, Y Tsukawaki, K Ogli, A Yokono
No abstract text is available yet for this article.
January 1984: Masui. the Japanese Journal of Anesthesiology
https://www.readbyqxmd.com/read/2954811/which-potent-opioid-important-criteria-for-selection
#19
J G Bovill
Opioids remain the drugs of choice for the treatment of severe pain. In recent years several new potent opioids have become available for clinical use. These newer drugs are generally safer than the older morphine-like compounds and their differing pharmacological and pharmacokinetic properties allow the physician to choose an appropriate drug according to the clinical situation and need of an individual patient. These drugs are classified according to their activity at the opioid receptors. The opioid agonists produce their pharmacological effect by an almost exclusive action at mu-receptors...
May 1987: Drugs
https://www.readbyqxmd.com/read/2861882/-new-morphine-type-analgesics-in-anesthesia
#20
REVIEW
J J Lehot, O Bastien, C Girard, L Ruynat, M Tartulier
Since the synthesis of Fentanyl in 1961, many narcotics have appeared which are not yet available in France. Among agonists, all are Fentanyl derivates but are different by either more powerful (sufentanyl, lofentanyl), and longer-acting effects (lofentanyl), or less powerful and shorter-acting effects (alfentanyl). All would have a greater security index and minimal cardiovascular side effects. Among agonists-antagonists, only pentazocine is available in France for analgesic therapy. The interest of other new molecules as butorphenol, nalbuphine and buprenorphine, which are available in other countries, still remains a matter of discussion...
April 1985: Cahiers D'anesthésiologie
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