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immunotherapy allergen

P González Delgado, E Ibáñez Echevarría, M Antón Gironés, M Rodríguez Mosquera, M D Alonso Díaz de Durana, P Prieto Montaño, A Marín de Pablo, M Fernández-Rivas
No abstract text is available yet for this article.
April 2018: Journal of Investigational Allergology & Clinical Immunology
Amy M Scurlock
Development of active therapies for IgE-mediated food allergy is a critical action step toward alleviating the adverse medical, psychosocial, and economic burdens on affected patients and families. Significant progress has been observed specifically in the application of single-allergen oral and sublingual immunotherapy for treatment of IgE-mediated food allergy, with emphasis on milk, egg, and peanut as the primary allergens. Oral immunotherapy (OIT) has demonstrated efficacy in promoting immunomodulatory effects that lead to the clinical outcome of desensitization, defined as reduced reactivity while on active OIT, in the majority of treated individuals; however, achievement of sustained unresponsiveness following cessation of therapy has been observed in a smaller subset of treated subjects...
April 14, 2018: Clinical Reviews in Allergy & Immunology
David I Bernstein, Joerg Kleine-Tebbe, Harold S Nelson, Jose A Bardelas, Gordon L Sussman, Susan Lu, Dorte Rehm, Bodil Svanholm Fogh, Hendrik Nolte
BACKGROUND: Allergic rhinitis with or without conjunctivitis (AR/C) is common, necessitating evaluation of SQ house dust mite (HDM) sublingual immunotherapy (SLIT)-tablet efficacy in various subgroups. OBJECTIVE: To evaluate 12 SQ-HDM efficacy and safety across subgroups, and the onset, duration, and recurrence of local application site reactions. METHODS: Subgroup (age, gender, race, asthma status, and allergen sensitization) efficacy was assessed using pooled data from two previously described trials of daily 12 SQ-HDM vs placebo for AR/C (N=2138)...
April 12, 2018: Annals of Allergy, Asthma & Immunology
Jessica J O'Konek, Jeffrey J Landers, Katarzyna W Janczak, Rishi R Goel, Anna M Mondrusov, Pamela T Wong, James R Baker
BACKGROUND: Immunotherapy for food allergies involves progressive increased exposures to food that result in desensitization to food allergens in some subjects but not tolerance to the food. Therefore new approaches to suppress allergic immunity to food are necessary. Previously, we demonstrated that intranasal immunization with a nanoemulsion (NE) adjuvant induces robust mucosal antibody and TH 17-polarized immunity, as well as systemic TH 1-biased cellular immunity with suppression of pre-existing TH 2-biased immunity...
April 11, 2018: Journal of Allergy and Clinical Immunology
J M Orengo, A R Radin, V Kamat, A Badithe, L H Ben, B L Bennett, S Zhong, D Birchard, A Limnander, A Rafique, J Bautista, A Kostic, D Newell, X Duan, M C Franklin, W Olson, T Huang, N A Gandhi, L Lipsich, N Stahl, N J Papadopoulos, A J Murphy, G D Yancopoulos
Acute allergic symptoms are caused by allergen-induced crosslinking of allergen-specific immunoglobulin E (IgE) bound to Fc-epsilon receptors on effector cells. Desensitization with allergen-specific immunotherapy (SIT) has been used for over a century, but the dominant protective mechanism remains unclear. One consistent observation is increased allergen-specific IgG, thought to competitively block allergen binding to IgE. Here we show that the blocking potency of the IgG response to Cat-SIT is heterogeneous...
April 12, 2018: Nature Communications
B Bonnet, K Messaoudi, F Jacomet, E Michaud, J L Fauquert, D Caillaud, B Evrard
Background: Cats are the major source of indoor inhalant allergens after house dust mites. The global incidence of cat allergies is rising sharply, posing a major public health problem. Ten cat allergens have been identified. The major allergen responsible for symptoms is Fel d 1, a secretoglobin and not a lipocalin, making the cat a special case among mammals. Main body: Given its clinical predominance, it is essential to have a good knowledge of this allergenic fraction, including its basic structure, to understand the new exciting diagnostic and therapeutic applications currently in development...
2018: Allergy, Asthma, and Clinical Immunology
Jessika R Richards, Janice L Stumpf
OBJECTIVE: To review the published literature evaluating administration of house dust mite (HDM) sublingual immunotherapy (SLIT) in pediatric patients with allergic asthma. DATA SOURCES: PubMed database search (1966 to November 2017) using the search terms allergy, allergic rhinitis, asthma, allergic asthma, house dust mite, allergen immunotherapy, subcutaneous immunotherapy, sublingual immunotherapy, MK-8237, children, and pediatric. Package labeling and references from identified articles were also reviewed...
April 1, 2018: Annals of Pharmacotherapy
Valentina Pecora, Maurizio Mennini, Veronica Calandrelli, Giampiero Patriarca, Rocco Valluzzi, Vincenzo Fierro
PURPOSE OF REVIEW: In the last years, food allergy treatment is moving away from food avoidance to interventional treatments. We review here the recent developments on immunotherapy with food allergens. RECENT FINDINGS: Oral immunotherapy remains the best studied form of food immunotherapy. In 2017, further evidence has been added to its efficacy. Its mechanisms of action are under scrutiny. To reduce its side effects, studies have been dedicated to the simultaneous use of biologics, in particular omalizumab...
April 6, 2018: Current Opinion in Allergy and Clinical Immunology
Désirée Larenas-Linnemann, Jorge A Luna-Pech
PURPOSE OF REVIEW: Allergen immunotherapy (AIT) is a well recognized and extensively studied therapeutic intervention for some allergic diseases. Every year new systematic reviews and meta-analysis provide the most powerful source of evidence to orient decision making on prevention or efficacy of AIT. We here discuss systematic reviews and meta-analyses on AIT (published January 2017 to February 2018). RECENT FINDINGS: We identified 4 systematic reviews and 10 meta-analyses...
April 6, 2018: Current Opinion in Allergy and Clinical Immunology
Raheleh Shokouhi Shoormasti, Mohammad Reza Fazlollahi, Anoshirvan Kazemnejad, Masoud Movahedi, Behnoosh Tayebi, Zahra Yazdanyar, Zakieh Azadi, Zahra Pourpak, Mostafa Moin
Background and aim: Standardized techniques help us to better diagnosis and follow up of allergic diseases. In this study, we determined the sensitivity, accuracy, and specificity of an Immunoblotting test compared to ImmunoCAP as the reference in vitro test for detection of specific IgE in allergic patients. Methods: In this cross-sectional study, specific IgE level was determined in patients with allergic symptoms who referred to the Immunology, Asthma and Allergy Research Institute, Tehran, Iran from 2010-2016, by two techniques...
February 2018: Electronic Physician
Yin Yao, Cai-Ling Chen, Nan Wang, Zhi-Chao Wang, Jin Ma, Rong-Fei Zhu, Xiao-Yan Xu, Peng-Cheng Zhou, Di Yu, Zheng Liu
Allergen-specific IL-4+ Tfh cells may contribute to allergen-specific IgE production and correlate with clinical efficacy of AIT in AR patients, which may be a promising therapeutic target and biomarker for AIT in AR.
April 4, 2018: Journal of Allergy and Clinical Immunology
Sara Anvari, Katherine Anagnostou
Food allergies are on the rise and have a major impact on the quality of life of the food allergic child and their family. Currently, the mainstream treatment for food allergies is strict avoidance and elimination of the allergenic food(s) from the patient's diet in order to prevent an allergic reaction. However, recent advances in research have presented new therapeutic options for food allergic patients that are potentially becoming promising alternatives to traditional treatment. Food immunotherapy is the most popular of these new emerging interventions and has been studied intensively over the last decade for various foods...
April 4, 2018: Children
P Wilkołek, W Sitkowski, M Szczepanik, Ł Adamek, M Pluta, I Taszkun, M Gołyński, A Malinowska
Allergic responses in humans, horses and other species are mediated by immunoglobulin E (IgE) antibodies. Serum testing to detect allergen-specific IgE antibodies has been developed for dogs, cats and horses; this allows for the identification of allergens and determination of appropriate allergen- specific immunotherapies. This study compared serum allergen-specific IgE concentrations in atopic and healthy horses. The study was performed on Malopolski breed atopic (n=21) and nonatopic (n=21) clinically healthy horses...
December 2017: Polish Journal of Veterinary Sciences
Susanne C Diesner, Cornelia Bergmayr, Xue-Yan Wang, Denise Heiden, Sarah Exenberger, Franziska Roth-Walter, Philipp Starkl, Davide Ret, Isabella Pali-Schöll, Franz Gabor, Eva Untersmayr
To improve current mucosal allergen immunotherapy Vibrio cholerae neuraminidase (NA) was evaluated as a novel epithelial targeting molecule for functionalization of allergen-loaded, poly(D,L-lactide-co-glycolide) (PLGA) microparticles (MPs) and compared to the previously described epithelial targeting lectins wheat germ agglutinin (WGA) and Aleuria aurantia lectin (AAL). All targeters revealed binding to Caco-2 cells, but only NA had high binding specificity to α-L fucose and monosialoganglioside-1. An increased transepithelial uptake was found for NA-MPs in a M-cell co-culture model...
March 30, 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
Ewa M Czarnobilska, Małgorzata Bulanda, Radosław Śpiewak
Introduction: In clinical practice, reliable tools for monitoring specific immunotherapy (SIT) are of utmost importance. Aim: To assess the usefulness of the basophil activation test (BAT) in monitoring SIT in paediatric patients with allergy to house dust mites (HDM). Material and methods: Thirty-one children qualified for SIT with HDM, of whom 21 completed the SIT during the observation period. The BAT was carried out prior to commencing the SIT (time point BAT1) and upon finishing the initial pack of allergy vaccine (cumulative dose of allergen 12487...
February 2018: Postȩpy Dermatologii i Alergologii
Deborah S Leuthard, Agathe Duda, Sandra N Freiberger, Sina Weiss, Isabella Dommann, Gabriele Fenini, Emmanuel Contassot, Matthias F Kramer, Murray A Skinner, Thomas M Kündig, Matthew D Heath, Pål Johansen
Allergen immunotherapy (AIT) is the only modality that can modify immune responses to allergen exposure, but therapeutic coverage is low. One strategy to improve AIT safety and efficacy is the use of new or improved adjuvants. This study investigates immune responses produced by microcrystalline tyrosine (MCT)-based vaccines as compared with conventional aluminum hydroxide (alum). Wild-type, immune-signaling-deficient, and TCR-transgenic mice were treated with different Ags (e.g., OVA and cat dander Fel d 1), plus MCT or alum as depot adjuvants...
March 28, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
Meng Chen, Michael Welch, Susan Laubach
The rising prevalence of food allergy and specifically peanut allergy has had significant implications for affected patients, families, and society. The current standard of care remains strict avoidance and the use of emergency medications for accidental ingestions. There is recent evidence-based information to suggest that one approach to preventing peanut allergy lies in early introduction of peanut. This represents a paradigm shift from previous recommendations and has led to updated guidelines in the United States, Europe, and Australasia on the introduction of potentially allergenic foods in the infant diet...
March 1, 2018: Pediatric Allergy, Immunology, and Pulmonology
Jaymin B Morjaria, Massimo Caruso, Rosalia Emma, Cristina Russo, Riccardo Polosa
PURPOSE OF REVIEW: To evaluate the impact of allergic rhinitis (AR) on the development of asthma and to update readers on recent literature suggesting that early treatment of allergic subjects with immunotherapy may prevent asthma onset. RECENT FINDINGS: AR is frequently associated with asthma, leading to the concept that these two conditions are different aspects of the same disease. There is increasing evidence that AR precedes the onset of asthmatic symptoms and current treatment strategies are beneficial in symptom control with no impact prevention...
March 24, 2018: Current Allergy and Asthma Reports
Jessica L Rice, Gregory B Diette, Catalina Suarez-Cuervo, Emily P Brigham, Sandra Y Lin, Murugappan Ramanathan, Karen A Robinson, Antoine Azar
CONTEXT: Treatment options for allergic asthma include allergen avoidance, pharmacotherapy, and allergen immunotherapy. OBJECTIVES: Summarize and update current evidence for the efficacy and safety of subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) in pediatric allergic asthma. DATA SOURCES: PubMed, Embase, Cochrane Central Register of Controlled Trials (January 1, 2005, through May 8, 2017),, and the US Food and Drug Administration Adverse Event Reporting System...
March 23, 2018: Pediatrics
Songwe Fanuel, Saeideh Tabesh, Kobra Mokhtarian, Esmaeil Saroddiny, Mohammad Reza Fazlollahi, Zahra Pourpak, Reza Falak, Gholam Ali Kardar
AIM: House dust mite (HDM) allergens are important elicitors of IgE-mediated allergies. This study was aimed at constructing and characterizing a recombinant fusion protein, DpTTDp, which was based on carrier-bound Der p 1-derived peptides for HDM allergen immunotherapy. METHODS: Using the Immune Epitope Database (IEDB), we identified from Der p 1, a 34-mer hypoallergenic peptide. Two copies of the hypoallergen were then fused to a partial fragment of a tetanus toxoid molecule's N-and C terminus and expressed in Escherichia coli...
March 23, 2018: Immunotherapy
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