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immunotherapy allergen

Laila Hellkvist, Eric Hjalmarsson, Susanna Kumlien Georén, Agnetha Karlsson, Karin Lundkvist, Ola Winqvist, Ulla Westin, Lars Olaf Cardell
Intralymphatic immunotherapy (ILIT) with only three lymph node-injections was performed with a combination of grass and birch allergen, with maintained safety and reduced reactivity at nasal grass allergen challenge.
June 13, 2018: Journal of Allergy and Clinical Immunology
Daniel M Moldaver, Mantej S Bharhani, Christopher D Rudulier, Jennifer Wattie, Mark D Inman, Mark Larché
BACKGROUND: Treatment of cat allergic subjects with peptides derived from Fel d 1 (the major cat allergen) ameliorated symptoms of cat allergy in phase 2 clinical trials. OBJECTIVE: To demonstrate that the tolerance induced by Fel d 1 peptide immunotherapy can be exploited to reduce allergic responses to a second allergen, ovalbumin (OVA), in mice dually sensitized to OVA and Fel d 1. METHODS: The induction of tolerance to OVA was achieved via a simultaneous exposure to both allergens following peptide treatment...
June 12, 2018: Journal of Allergy and Clinical Immunology
Paloma Campo, Ibon Eguiluz-Gracia, Gador Bogas, María Salas, Carmen Plaza Serón, Natalia Pérez, C Mayorga, M J Torres, Mohammed Shamji, Carmen Rondon
A significant proportion of rhinitis patients without systemic IgE-sensitization tested by skin prick test and serum allergen-specific IgE (sIgE) display nasal reactivity upon nasal allergen provocation test (NAPT). This disease phenotype has been termed local allergic rhinitis (LAR). LAR is an underdiagnosed entity affecting children and adults from different parts of the world, with moderate-to-severe symptoms, impairment of quality of life and rapid progression to symptom worsening. LAR is a stable phenotype and not merely an initial state of AR...
June 14, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Mirela Curin, Musa Khaitov, Alexander Karaulov, Leyla Namazova-Baranova, Raffaela Campana, Victoria Garib, Rudolf Valenta
PURPOSE OF REVIEW: The aim of this article is to discuss how allergen-specific immunotherapy (AIT) can be improved through molecular approaches. We provide a summary of next-generation molecular AIT approaches and of their clinical evaluation. Furthermore, we discuss the potential of next generation molecular AIT forms for the treatment of severe manifestations of allergy and mention possible future molecular strategies for the secondary and primary prevention of allergy. RECENT FINDINGS: AIT has important advantages over symptomatic forms of allergy treatment but its further development is limited by the quality of the therapeutic antigen preparations which are derived from natural allergen sources...
June 9, 2018: Current Allergy and Asthma Reports
Sandra Y Lin, Antoine Azar, Catalina Suarez-Cuervo, Gregory B Diette, Emily Brigham, Jessica Rice, Murugappan Ramanathan, Karen A Robinson
BACKGROUND: The purpose of the systematic review is to evaluate the efficacy and safety of sublingual immunotherapy (SLIT) for the treatment of allergic asthma. METHODS: PubMed, Embase, and CENTRAL databases were searched, updating an earlier review (January 1, 2005 through May 8, 2017). Randomized, controlled studies (RCTs) were included, which reported one of the prespecified outcomes: asthma symptoms measured by control composite scores; quality of life; medication use; pulmonary physiology; and health-care utilization...
June 9, 2018: International Forum of Allergy & Rhinology
Fatma Tritar, Majed Béji, A Ben Khedher, Mohamed Ridha Charfi, A El Kamel, K Rekik, H Daghfous, J Ammar, S Azabi, Z Souissi, S Taktak, Ikram Drira, M Smaoui, Boubaker Zakhama
No abstract text is available yet for this article.
August 2017: La Tunisie Médicale
Sangeeta Dhami, Arnav Agarwal
PURPOSE OF REVIEW: Cat allergy can manifest as allergic rhinitis, conjunctivitis and/or asthma. With widespread cat ownership and exposure, cat allergy has emerged as a major cause of morbidity. Cat allergen immunotherapy is a potential disease modifying treatment for patients with cat allergy. We examine evidence on the effectiveness, cost-effectiveness and safety of cat allergen immunotherapy and consider the clinical contexts in which it should be prescribed. RECENT FINDINGS: The European Association of Allergy and Clinical Immunology systematic reviews on allergic rhinitis and asthma along with the accompanying guidelines on allergic rhinitis were used as primary sources of evidence...
June 4, 2018: Current Opinion in Allergy and Clinical Immunology
Simone M Hayen, Henny G Otten, Saskia A Overbeek, André C Knulst, Johan Garssen, Linette E M Willemsen
Background: Non-digestible oligosaccharides promote colonization of beneficial gut bacteria and have direct immunomodulatory effects. Apical exposure of intestinal epithelial cells (IECs) to short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides (scGOS/lcFOS) in a transwell co-culture model enhanced the CpG-induced (TLR-9 ligand) T helper 1 (Th1) phenotype and regulatory IL-10 response of underlying peripheral mononuclear cells (PBMCs) of healthy donors. scGOS is derived from lactose and may pose risks in severe cow's milk allergic patients, and scFOS/lcFOS may be an alternative...
2018: Frontiers in Immunology
Richard L Wasserman, Angela R Hague, Deanna M Pence, Robert W Sugerman, Stacy K Silvers, Joanna G Rolen, Morley Herbert
BACKGROUND: Peanut allergy (PA) is a significant and increasing problem, interfering with psychological development and family life. The standard recommendation to avoid peanut products and have access to injectable epinephrine is often inadequate. Oral immunotherapy for PA has been formally studied. Clinical observations of allergen immunotherapy have repeatedly enhanced patient care. OBJECTIVE: The purpose of this study is to report observations on the treatment of 270 PA patients over 8...
May 30, 2018: Journal of Allergy and Clinical Immunology in Practice
Petra Bacher, Alexander Scheffold
The mucosal immune system of the respiratory tract is specialized to continuously monitor the external environment and to protect against invading pathogens, while maintaining tolerance to innocuous inhaled particles. Allergies result from a loss of tolerance against harmless antigens characterized by formation of allergen-specific Th2 cells and IgE. Tolerance is often described as a balance between harmful Th2 cells and various types of protective "regulatory" T cells. However, the identity of the protective T cells in healthy vs...
June 1, 2018: Mucosal Immunology
Akihiro Maeta, Marin Matsushima, Risako Katahira, Natsumi Sakamoto, Kyoko Takahashi
BACKGROUND: The objective of this study was to determine the required concentration of egg white (EW) in the diet to induce oral desensitization and/or immune tolerance within 4 weeks of oral immunotherapy (OIT) in an EW allergic mouse model. METHODS: Female BALB/c mice were systemically sensitized to EW by intraperitoneal injections and subsequently subjected to oral allergen gavage. Sensitized mice were provided 4 weeks of OIT by supplementing with 0 (non-OIT), 0...
May 30, 2018: International Archives of Allergy and Immunology
Carmen Rondón, Ibon Eguiluz-Gracia, Paloma Campo
PURPOSE OF REVIEW: To examine the recent advances on epidemiological studies, diagnostic approach and clinical management of local allergic rhinitis (LAR) in adults and children. RECENT FINDINGS: Evidence about LAR is growing especially in pediatric and Asian populations. The prevalence of LAR is lower in Asian countries compared with western countries in both children and adults. LAR is considered a chronic condition and an independent rhinitis phenotype that affects up to 26...
May 29, 2018: Current Opinion in Allergy and Clinical Immunology
Sara Haunstrup Næraa, Niels-Erik Harbo Schollert, Peter Nytofte Flader Skov, Preben Homøe
An emerging method for allergen-specific immunotherapy is intralymphatic placement, which only requires three injections with intervals of four weeks. In this review, we summarise available evidence on clinical safety, biological efficacy and therapeutic outcomes. The treatment appears to be safe with only few and mild adverse reactions. The immunological activation profile is comparable to that known for subcutaneous therapy. Clinically, patients experienced fewer symptoms with less medication use with intralymphatic allergen-specific immunotherapy than with other types of immunotherapy...
May 28, 2018: Ugeskrift for Laeger
Marek Lommatzsch
The new international and german asthma guidelines recommend a 5-step treatment approach, to achieve asthma control and to minimize future risk. Inhaled corticosteroids (ICS) are still the mainstay of treatment, which should be combined with long-acting bronchodilators in patients with more severe disease. Specific treatment options such as allergen-Immunotherapy (AIT) or biologics, which can be very efficacious in individual patients, are forerunners of a new era of precision medicine in asthma.
June 2018: Deutsche Medizinische Wochenschrift
Keisuke Masuyama, Tomokazu Matsuoka, Atsushi Kamijo
Japanese cedar pollen (JCP) and house dust mite (HDM) are two major allergens that cause allergic rhinitis (AR) in Japan and the prevalence of AR is increasing. Pharmacothearpy is a commonly used treatment, but the level of patient satisfaction is very low. Allergen immunotherapy (AIT) is the only therapeutic modality that provides not only symptom relief but also quality of life improvement that leads to a high rate of satisfaction. In particular, sublingual immunotherapy (SLIT) is a safe and effective treatment for AR...
May 25, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
Flore Amat, Lucile Sese, Marie Hayat, Mélisande Bourgoin-Heck, Jocelyne Just
No abstract text is available yet for this article.
May 24, 2018: Annals of Allergy, Asthma & Immunology
L Cheng
No abstract text is available yet for this article.
September 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Kostas Karatzas, Nikos Katsifarakis, Marina Riga, Barbora Werchan, Matthias Werchan, Uwe Berger, Oliver Pfaar, Karl-Christian Bergmann
BACKGROUND: The use of allergen immunotherapy (AIT) for allergic rhinitis and its clinical efficacy in clinical trials depends on the effective determination of pollen allergens exposure time-periods. We evaluate pollen data from Germany to examine the new definitions on pollen season and peak pollen period start and end as proposed by the European Academy of Allergy and Clinical Immunology (EAACI) in a recently published Position Paper. The aim was to demonstrate the ability of these definitions to mirror symptom loads for grass and birch pollen-induced allergic rhinitis based on real-life data...
May 23, 2018: Allergy
Yuanming Wang, Chuling Li, Yaxiong Xu, Deyu Xu, Gang Yang, Fang Liao, Xianglin Luo
OBJECTIVES: To identify the expression of IL-33 during SLIT (Sublingual immunotherapy) in AR (Allergic rhinitis) children. METHODS: Thirty children received house dust mite (HDM) allergen extract for SLIT and thirty children received placebo in this study. Serum and nasal lavage samples of cases and controls were collected at different time points during SLIT. Interleukin (IL)-33 and other cytokines were estimated in these samples by enzyme-linked immuno sorbent assay (ELISA)...
May 23, 2018: Indian Journal of Pediatrics
Kuan-Wei Chen, Laura Marusciac, Paul Tudor Tamas, Rudolf Valenta, Carmen Panaitescu
Ambrosia artemisiifolia, also known as common or short ragweed, is an invasive annual flowering herbaceous plant that has its origin in North America. Nowadays, ragweed can be found in many areas worldwide. Ragweed pollen is known for its high potential to cause type I allergic reactions in late summer and autumn and represents a major health problem in America and several countries in Europe. Climate change and urbanization, as well as long distance transport capacity, enhance the spread of ragweed pollen...
May 22, 2018: International Archives of Allergy and Immunology
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