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https://www.readbyqxmd.com/read/28817660/cited4-is-related-to-cardiogenic-induction-and-maintenance-of-proliferation-capacity-of-embryonic-stem-cell-derived-cardiomyocytes-during-in-vitro-cardiogenesis
#1
Junichiro Miake, Tomomi Notsu, Katsumi Higaki, Kyoko Hidaka, Takayuki Morisaki, Kazuhiro Yamamoto, Ichiro Hisatome
Cardiac progenitor cells have a limited proliferative capacity. The CREB-binding protein/p300-interacting transactivator, with the Glu/Asp-rich carboxy-terminal domain (Cited) gene family, regulates gene transcription. Increased expression of the Cited4 gene in an adult mouse is associated with exercise-induced cardiomyocyte hypertrophy and proliferation. However, the expression patterns and functional roles of the Cited4 gene during cardiogenesis are largely unknown. Therefore, in the present study, we investigated the expression patterns and functional roles of the Cited4 gene during in vitro cardiogenesis...
2017: PloS One
https://www.readbyqxmd.com/read/28811072/evolution-of-hemoglobin-loci-and-their-regulatory-elements
#2
REVIEW
Sjaak Philipsen, Ross C Hardison
Across the expanse of vertebrate evolution, each species produces multiple forms of hemoglobin in erythroid cells at appropriate times and in the proper amounts. The multiple hemoglobins are encoded in two globin gene clusters in almost all species. One globin gene cluster, linked to the gene NPRL3, is preserved in all vertebrates, including a gene cluster encoding the highly divergent globins from jawless vertebrates. This preservation of synteny may reflect the presence of a powerful enhancer of globin gene expression in the NPRL3 gene...
August 9, 2017: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/28809703/motion-based-rapid-serial-visual-presentation-for-gaze-independent-brain-computer-interfaces
#3
Dong-Ok Won, Han-Jeong Hwang, Dong-Min Kim, Klaus-Robert Muller, Seong-Whan Lee
Most event-related potential (ERP)-based braincomputer interface (BCI) spellers primarily use matrix layouts, and generally require moderate eye movement for successful operation. The fundamental objective of this study is to enhance the perceptibility of target characters by introducing motion stimuli to classical rapid serial visual presentation (RSVP) spellers that do not require any eye movement, thereby applying them to paralyzed patients with oculomotor dysfunctions. To test the feasibility of the proposed motion-based RSVP paradigm, we implemented three RSVP spellers: i) fixed-direction motion (FM-RSVP), ii) random-direction motion (RM-RSVP), and iii) (the conventional) non-motion stimulation (NM-RSVP), and evaluated the effect of the three different stimulation methods on spelling performance...
August 11, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28808655/multirapid-serial-visual-presentation-framework-for-eeg-based-target-detection
#4
Zhimin Lin, Ying Zeng, Hui Gao, Li Tong, Chi Zhang, Xiaojuan Wang, Qunjian Wu, Bin Yan
Target image detection based on a rapid serial visual presentation (RSVP) paradigm is a typical brain-computer interface system with various applications, such as image retrieval. In an RSVP paradigm, a P300 component is detected to determine target images. This strategy requires high-precision single-trial P300 detection methods. However, the performance of single-trial detection methods is relatively lower than that of multitrial P300 detection methods. Image retrieval based on multitrial P300 is a new research direction...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28803990/high-doses-of-baicalin-induces-kidney-injury-and-fibrosis-through-regulating-tgf-%C3%AE-smad-signaling-pathway
#5
Yi Cai, Wanqing Ma, Yichuan Xiao, Bo Wu, Xiaobing Li, Fengrong Liu, Jianhua Qiu, Genshui Zhang
Baicalin is a major flavonoid compound purified from Scutellariae radix, which has been described as an herb in the Chinese Pharmacopoeia. Previous studies have suggested baicalin possessed extensive anti-inflammatory, anti-cancer, anti-viral properties. However, up to known, there have been no reports of safety and toxicity in the rats following oral administration of baicalin. In this present study, we showed the first evidence that treatment of baicalin (400, 800 and 1600mg/kg/day) induced significantly kidney injury and fibrosis...
August 10, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28801636/inhibition-of-hypoxic-response-decreases-stemness-and-reduces-tumorigenic-signaling-due-to-impaired-assembly-of-hif1-transcription-complex-in-pancreatic-cancer
#6
Olivia McGinn, Vineet K Gupta, Patricia Dauer, Nivedita Arora, Nikita Sharma, Alice Nomura, Vikas Dudeja, Ashok Saluja, Sulagna Banerjee
Pancreatic tumors are renowned for their extremely hypoxic centers, resulting in upregulation of a number of hypoxia mediated signaling pathways including cell proliferation, metabolism and cell survival. Previous studies from our laboratory have shown that Minnelide, a water-soluble pro-drug of triptolide (anti-cancer compound), decreases viability of cancer cells in vitro as well as in vivo. However, its mechanism of action remain elusive. In the current study we evaluated the effect of Minnelide, on hypoxia mediated oncogenic signaling as well as stemness in pancreatic cancer...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28800972/intranasal-oxytocin-and-the-neural-correlates-of-infant-face-processing-in-non-parent-women
#7
Helena J V Rutherford, Xiaoyue M Guo, Kelsey M Graber, Nathan J Hayes, Kevin A Pelphrey, Linda C Mayes
Event-related potentials (ERPs) have been widely employed to identify different stages of face processing, with recent research probing the neural dynamics of adult's processing of infant faces. Infant faces represent a salient category of visual stimuli, especially in parents, likely prioritized for processing through activity of the oxytocinergic system. Here we employed a randomized, double-blind, and within-subject crossover study of 24 non-parent women to examine the impact of intranasal oxytocin administration, relative to placebo, on processing infant and adult faces...
August 8, 2017: Biological Psychology
https://www.readbyqxmd.com/read/28798030/ethanol-exposure-regulates-gabra1-expression-via-histone-deacetylation-at-the-promoter-in-cultured-cortical-neurons
#8
John Peyton Bohnsack, Vraj K Patel, A Leslie Morrow
GABAA-Rs mediate the majority of inhibitory neurotransmission in the adult brain. α1-containing GABAA-Rs are the most prominent subtype in the adult brain, and are important in both homeostatic function and several disease pathologies including alcohol dependence, epilepsy, and stress. Ethanol exposure causes a decrease of α1 transcription and peptide expression both in vivo and in vitro, but the mechanism that controls the transcriptional regulation is unknown. Since ethanol is known to activate epigenetic regulation of gene expression, we tested the hypothesis that ethanol regulates α1 expression through histone modifications in cerebral cortical cultured neurons...
August 10, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28793344/neurocognitive-mechanisms-underlying-deceptive-hazard-evaluation-an-event-related-potentials-investigation
#9
Huijian Fu, Wenwei Qiu, Haiying Ma, Qingguo Ma
Deceptive behavior is common in human social interactions. Researchers have been trying to uncover the cognitive process and neural basis underlying deception due to its theoretical and practical significance. We used Event-related potentials (ERPs) to investigate the neural correlates of deception when the participants completed a hazard judgment task. Pictures conveying or not conveying hazard information were presented to the participants who were then requested to discriminate the hazard content (safe or hazardous) and make a response corresponding to the cues (truthful or deceptive)...
2017: PloS One
https://www.readbyqxmd.com/read/28790910/hybrid-brain-computer-interface-techniques-for-improved-classification-accuracy-and-increased-number-of-commands-a-review
#10
REVIEW
Keum-Shik Hong, Muhammad Jawad Khan
In this article, non-invasive hybrid brain-computer interface (hBCI) technologies for improving classification accuracy and increasing the number of commands are reviewed. Hybridization combining more than two modalities is a new trend in brain imaging and prosthesis control. Electroencephalography (EEG), due to its easy use and fast temporal resolution, is most widely utilized in combination with other brain/non-brain signal acquisition modalities, for instance, functional near infrared spectroscopy (fNIRS), electromyography (EMG), electrooculography (EOG), and eye tracker...
2017: Frontiers in Neurorobotics
https://www.readbyqxmd.com/read/28782640/effect-of-melatonin-on-neuronal-differentiation-requires-cbp-p300-mediated-acetylation-of-histone-h3-lysine-14
#11
Xian Li, Xueran Chen, Wenjuan Zhou, Shufang Ji, Xinyue Li, Guanchong Li, Guowei Liu, Fuwu Wang, Aijun Hao
The transition from multipotent neural stem cells (NSCs) to terminally differentiated neurons is a multistep process, and the transition is finely regulated by transcription factors with basic helix-loop-helix (bHLH) motifs. Melatonin is an endogenous neurohormone with profound neurotrophic and neuroprotective effects both during the embryonic developmental stage and adulthood. The effects of melatonin on the differentiation of NSCs have been reported, and these effects may be responsible for its neuroprotective properties...
August 3, 2017: Neuroscience
https://www.readbyqxmd.com/read/28774794/the-acute-effects-of-aerobic-exercise-on-cognitive-control-among-people-with-chronic-stroke
#12
Karli Swatridge, Kayla Regan, William Richard Staines, Eric Roy, Laura Elizabeth Middleton
BACKGROUND: Over half of stroke survivors have cognitive impairment, which impedes rehabilitation and functional recovery. Evidence suggests a single session of aerobic exercise improves cognitive functions among healthy adults. Whether this holds true for stroke survivors is unclear. The objective of this study was to examine whether one session of moderate-intensity aerobic exercise improves the cognitive control and attention of stroke survivors. METHODS: Nine people with chronic stroke (≥6 months poststroke) performed a modified Eriksen Flanker task with concurrent electroencephalography (EEG) before and immediately, 20 minutes, and 40 minutes after 20 minutes of moderate-intensity exercise and after 20 minutes of rest...
July 31, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28769825/a-pilot-study-of-possible-easy-to-use-electrophysiological-index-for-early-detection-of-antidepressive-treatment-non-response
#13
Goded Shahaf, Shahak Yariv, Boaz Bloch, Uri Nitzan, Aviv Segev, Alon Reshef, Yuval Bloch
INTRODUCTION: The evaluation of response to pharmacological treatment in MDD requires 4-8 weeks. Therefore, the ability to predict response, and especially lack of response to treatment, as early as possible after treatment onset or change, is of prime significance. Many studies have demonstrated significant results regarding the ability to use EEG and ERP markers, including attention-associated markers such as P300, for early prediction of response to treatment. But these markers are derived from long EEG/ERP samples, often from multiple channels, which render them impractical for frequent sampling...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28768151/tuned-by-experience-how-orientation-probability-modulates-early-perceptual-processing
#14
Syaheed B Jabar, Alex Filipowicz, Britt Anderson
Probable stimuli are more often and more quickly detected. While stimulus probability is known to affect decision-making, it can also be explained as a perceptual phenomenon. Using spatial gratings, we have previously shown that probable orientations are also more precisely estimated, even while participants remained naive to the manipulation. We conducted an electrophysiological study to investigate the effect that probability has on perception and visual-evoked potentials. In line with previous studies on oddballs and stimulus prevalence, low-probability orientations were associated with a greater late positive 'P300' component which might be related to either surprise or decision-making...
September 2017: Vision Research
https://www.readbyqxmd.com/read/28766825/beyond-the-bet-family-targeting-cbp-p300-with-4-acyl-pyrroles
#15
Martin Hügle, Xavier Lucas, Dmytro Ostrovskyi, Pierre Regenass, Stefan Gerhardt, Oliver Einsle, Mirjam Hau, Manfred Jung, Bernhard Breit, Stefan Günther, Daniel Wohlwend
BET bromodomain inhibitors are widely used both as chemical tools to study the biological role of their targets in living organisms, and as candidates for drug development against several cancer variants and human disorders. However, non-BET bromodomains such as those in p300 and CBP are less studied. Here, we introduce XDM-CBP, a highly potent and selective inhibitor for the bromodomains of CBP and p300 derived from a pan-selective BET BRD-binding fragment. In addition to X-ray crystal structure analysis and thermodynamic profiling, we used XDM-CBP in in vitro cell screenings of several cancer cell lines to study its inhibitory potential on cancer cell proliferation...
August 2, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28765831/the-dataset-describes-hif-1-%C3%AE-expression-and-lps-mediated-cytokine-production-in-mkp-1-deficient-bone-marrow-derived-murine-macrophages
#16
Harvinder Talwar, Christian Bauerfeld, Yusen Liu, Lobelia Samavati
The data presented in this article are related to the research article entitled "MKP-1 negatively regulates LPS-mediated IL-1β production through p38 activation and HIF-1α expression" (Talwar et al., 2017) [1]. This data describes that LPS-mediated p38 and JNK phosphorylation is enhanced in MKP-1 deficient macrophages. HIF-1α expression and its nuclear accumulation are significantly increased in the nuclear extracts of MKP-1 deficient BMDMs. MKP-1 deficient BMDMs exhibited higher expression of the coactivator p300 of HIF-1α both at baseline and after LPS challenge...
October 2017: Data in Brief
https://www.readbyqxmd.com/read/28761523/the-use-of-event-related-potential-p300-and-neuropsychological-testing-to-evaluate-cognitive-impairment-in-mild-traumatic-brain-injury-patients
#17
Puneet Nandrajog, Zamzuri Idris, Wan Nor Azlen, Alwani Liyana, Jafri Malin Abdullah
BACKGROUND: The aim of the study is to compare the amplitude and latency of the P300 event-related potential (ERP) component between a control group and patients after mild traumatic brain injury (mTBI) during 1-7 days (short duration) and 2-3 months (long duration), and to compare the outcome of neuropsychological tests between the long duration postinjury and control study groups. MATERIALS AND METHODS: We studied responses to auditory stimulation in two main and one subgroups, namely the control healthy group (19 patients, both ERP and neuropsychology test done), the mTBI 1 group (17 patients, only ERP done within 7 days after injury), and the mTBI 2 subgroup (the 17 mTBI 1 patients in whom a repeated ERP together with neuropsychological testing was done at 2-3 months postinjury)...
July 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28760486/a-novel-brain-computer-interface-for-classification-of-social-joint-attention-in-autism-and-comparison-of-3-experimental-setups-a-feasibility-study
#18
Carlos P Amaral, Marco A Simões, Susana Mouga, João Andrade, Miguel Castelo-Branco
BACKGROUND: We present a novel virtual-reality P300-based Brain Computer Interface (BCI) paradigm using social cues to direct the focus of attention. We combined interactive immersive virtual-reality (VR) technology with the properties of P300 signals in a training tool which can be used in social attention disorders such as autism spectrum disorder (ASD). NEW METHOD: We tested the novel social attention training paradigm (P300-based BCI paradigm for rehabilitation of joint-attention skills) in 13 healthy participants, in 3 EEG systems...
July 29, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28759294/epidermal-growth-factor-receptor-activation-promotes-ada3-acetylation-through-the-akt-p300-pathway
#19
Shashank Srivastava, Shakur Mohibi, Sameer Mirza, Hamid Band, Vimla Band
The ADA3 (Alteration/Deficiency in Activation 3) protein is an essential adaptor component of several Lysine Acetyltransferase (KAT) complexes involved in chromatin modifications. Previously, we and others have demonstrated a crucial role of ADA3 in cell cycle progression and maintenance of genomic stability. Recently, we have shown that acetylation of ADA3 is key to its role in cell cycle progression. Here, we demonstrate that AKT activation downstream of Epidermal Growth Factor Receptor (EGFR) family proteins stimulation leads to phosphorylation of p300, which in turn promotes the acetylation of ADA3...
July 31, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28757384/znf509s1-downregulates-puma-by-inhibiting-p53k382-acetylation-and-p53-dna-binding
#20
Bu-Nam Jeon, Jae-Hyeon Yoon, Dohyun Han, Min-Kyeong Kim, Youngsoo Kim, Seo-Hyun Choi, Jiyang Song, Kyung-Sup Kim, Kunhong Kim, Man-Wook Hur
Expression of the POK family protein ZNF509L, and -its S1 isoform, is induced by p53 upon exposure to genotoxic stress. Due to alternative splicing of the ZNF509 primary transcript, ZNF509S1 lacks the 6 zinc-fingers and C-terminus of ZNF509L, resulting in only one zinc-finger. ZNF509L and -S1 inhibit cell proliferation by activating p21/CDKN1A and RB transcription, respectively. When cells are exposed to severe DNA damage, p53 activates PUMA (p53-upregulated modulator of apoptosis) transcription. Interestingly, apoptosis due to transcriptional activation of PUMA by p53 is attenuated by ZNF509S1...
July 27, 2017: Biochimica et Biophysica Acta
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