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https://www.readbyqxmd.com/read/28334776/structural-characterization-of-interactions-between-transactivation-domain-1-of-the-p65-subunit-of-nf-%C3%AE%C2%BAb-and-transcription-regulatory-factors
#1
Lauriane Lecoq, Luca Raiola, Philippe R Chabot, Normand Cyr, Geneviève Arseneault, Pascale Legault, James G Omichinski
p65 is a member of the NF-κB family of transcriptional regulatory proteins that functions as the activating component of the p65-p50 heterodimer. Through its acidic transactivation domain (TAD), p65 has the capacity to form interactions with several different transcriptional regulatory proteins, including TFIIB, TFIIH, CREB-binding protein (CBP)/p300 and TAFII31. Like other acidic TADs, the p65 TAD contains two subdomains (p65TA1 and p65TA2) that interact with different regulatory factors depending on the target gene...
February 28, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28324996/analysis-of-the-non-stationarity-of-neural-activity-during-an-auditory-oddball-task-in-schizophrenia
#2
P Nunez, J Poza, J Gomez-Pilar, A Bachiller, C Gomez, A Lubeiro, V Molina, R Hornero
The aim of this study was to characterize brain dynamics during an auditory oddball task. For this purpose, a measure of the non-stationarity of a given time-frequency representation (TFR) was applied to electroencephalographic (EEG) signals. EEG activity was acquired from 20 schizophrenic (SCH) patients and 20 healthy controls while they underwent a three-stimulus auditory oddball task. The Degree of Stationarity (DS), a measure of the non-stationarity of the TFR, was computed using the continuous wavelet transform...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28322791/lps-depletes-phlpp-levels-in-macrophages-through-the-inhibition-of-sp1-dependent-transcriptional-regulation
#3
Neeraja P Alamuru-Yellapragada, Sanghamitra Vundyala, Soma Behera, Kishore V L Parsa
We have previously reported that bacterial endotoxin LPS attenuates expression of PHLPP, a ser/thr phosphatase, at both transcript and protein levels in different immune cells, however the underlying molecular mechanism is unknown and is of significant interest. Here, in line with the decreased transcript levels upon LPS treatment, we observed that LPS caused significant reduction in PHLPP promoter activity. We observed that SP1, a transcription factor frequently associated with inflammation, was recruited to the PHLPP promoter region...
March 18, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28316617/an-efficient-framework-for-eeg-analysis-with-application-to-hybrid-brain-computer-interfaces-based-on-motor-imagery-and-p300
#4
Jinyi Long, Jue Wang, Tianyou Yu
The hybrid brain computer interface (BCI) based on motor imagery (MI) and P300 has been a preferred strategy aiming to improve the detection performance through combining the features of each. However, current methods used for combining these two modalities optimize them separately, which does not result in optimal performance. Here, we present an efficient framework to optimize them together by concatenating the features of MI and P300 in a block diagonal form. Then a linear classifier under a dual spectral norm regularizer is applied to the combined features...
2017: Computational Intelligence and Neuroscience
https://www.readbyqxmd.com/read/28315726/social-distance-influences-the-outcome-evaluation-of-cooperation-and-conflict-evidence-from-event-related-potentials
#5
Yezi Chen, Jiamei Lu, Yiwen Wang, Zhouqi Feng, Bo Yuan
Previous research shows that social distance plays an important role in promoting cooperation and that subtle cues that reduce social distance increase the tendency to cooperate. However, it is unclear how social distance influences our outcome evaluation of cooperative and conflict feedback. The present study investigated the influence of social distance on cooperative and conflict behavior and the evaluation process of the cooperative and conflict outcomes, using the event-related potentials (ERPs) technique...
March 15, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28314201/inhibition-of-mirna-212-132-improves-the-reprogramming-of-fibroblasts-into-induced-pluripotent-stem-cells-by-de-repressing-important-epigenetic-remodelling-factors
#6
Nils Pfaff, Steffi Liebhaber, Selina Möbus, Abbas Beh-Pajooh, Jan Fiedler, Angelika Pfanne, Axel Schambach, Thomas Thum, Tobias Cantz, Thomas Moritz
MicroRNAs (miRNAs) repeatedly have been demonstrated to play important roles in the generation of induced pluripotent stem cells (iPSCs). To further elucidate the molecular mechanisms underlying transcription factor-mediated reprogramming we have established a model, which allows for the efficient screening of whole libraries of miRNAs modulating the generation of iPSCs from murine embryonic fibroblasts. Applying this model, we identified 14 miRNAs effectively inhibiting iPSC generation, including miR-132 and miR-212...
March 7, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28306348/differences-in-dyslexic-students-before-and-after-a-remediation-program-a-clinical-neuropsychological-and-event-related-potential-study
#7
Nikolaos C Zygouris, Elias Avramidis, Argyris V Karapetsas, George I Stamoulis
Developmental dyslexia is defined as an unexpected specific and persistent failure to acquire efficient reading skills despite conventional instruction, adequate intelligence and sociocultural opportunity. This article reports the outcomes of a study that evaluated the implementation of a 4-month intervention program. The intervention consisted of structured activities aiming at improving (a) the children's phonological awareness, (b) their visual and auditory memory, (c) their visual discrimination ability, and (d) their text comprehension...
March 17, 2017: Applied Neuropsychology. Child
https://www.readbyqxmd.com/read/28303949/the-processing-of-body-expressions-during-emotional-scenes-the-modulation-role-of-attachment-styles
#8
Yuanxiao Ma, Xu Chen, Guangming Ran, Haijing Ma, Xing Zhang, Guangzeng Liu
There is broad evidence indicating that contextual information influence the processing of emotional stimuli. However, attachment theory suggests that attachment styles contribute to the ways in which people perceive emotional events. To shed light on whether the processing of body expressions during different emotional scenes is modulated by attachment styles, attachment-related electrophysiological differences were measured using event-related potentials. For avoidantly attached group, our results suggested that larger N170 amplitudes were educed by neutral bodies than angry bodies, which was found only in neutral scene...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28301306/two-possible-modes-of-pioneering-associated-with-combinations-of-h2a-z-and-p300-cbp-at-nucleosome-occupied-enhancers
#9
Pierre Cauchy, Frederic Koch, Jean-Christophe Andrau
Pioneer transcription factors are defined by their ability to bind nucleosome-occupied regions. Here, we discuss the properties of nucleosomes bound by pioneers at enhancer regions. We describe how select pioneers bind nucleosome-occupied or -depleted enhancer sites. Importantly, by revisiting and expanding existing data sets, we show differential H2A.Z and p300/CBP association at bound enhancers, highlighting two possible pioneering modes.
February 13, 2017: Transcription
https://www.readbyqxmd.com/read/28299666/runx3-and-p53-how-two-tumor-suppressors-cooperate-against-oncogenic-ras
#10
Jung-Won Lee, Andre van Wijnen, Suk-Chul Bae
RUNX family members play pivotal roles in both normal development and neoplasia. In particular, RUNX1 and RUNX2 are essential for determination of the hematopoietic and osteogenic lineages, respectively. RUNX3 is involved in lineage determination of various types of epithelial cells. Analysis of mouse models and human cancer specimens revealed that RUNX3 acts as a tumor suppressor via multiple mechanisms. p53-related pathways play central roles in tumor suppression through the DNA damage response and oncogene surveillance, and RUNX3 is involved in both processes...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28298889/cortical-sensitivity-to-guitar-note-patterns-eeg-entrainment-to-repetition-and-key
#11
David A Bridwell, Emily Leslie, Dakarai Q McCoy, Sergey M Plis, Vince D Calhoun
Music is ubiquitous throughout recent human culture, and many individual's have an innate ability to appreciate and understand music. Our appreciation of music likely emerges from the brain's ability to process a series of repeated complex acoustic patterns. In order to understand these processes further, cortical responses were measured to a series of guitar notes presented with a musical pattern or without a pattern. ERP responses to individual notes were measured using a 24 electrode Bluetooth mobile EEG system (Smarting mBrainTrain) while 13 healthy non-musicians listened to structured (i...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28298888/reaching-and-grasping-a-glass-of-water-by-locked-in-als-patients-through-a-bci-controlled-humanoid-robot
#12
Rossella Spataro, Antonio Chella, Brendan Allison, Marcello Giardina, Rosario Sorbello, Salvatore Tramonte, Christoph Guger, Vincenzo La Bella
Locked-in Amyotrophic Lateral Sclerosis (ALS) patients are fully dependent on caregivers for any daily need. At this stage, basic communication and environmental control may not be possible even with commonly used augmentative and alternative communication devices. Brain Computer Interface (BCI) technology allows users to modulate brain activity for communication and control of machines and devices, without requiring a motor control. In the last several years, numerous articles have described how persons with ALS could effectively use BCIs for different goals, usually spelling...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28296173/snail-acetylation-by-histone-acetyltransferase-p300-in-lung-cancer
#13
Rui Chang, Yinjie Zhang, Peng Zhang, Qinghua Zhou
BACKGROUND: Epithelial to mesenchymal transition (EMT) is a complex and dynamic molecular event in lung cancer metastasis that has not yet been thoroughly investigated. EMT transcriptional factors, such as Snail, play a central role in regulation of the EMT process. In this study, we sought to identify an association between p300 and Snail in lung cancer, as well as the engagement of p300 in Snail acetylation. METHODS: We transfected p300 small interfering RNA into lung cancer cells to detect Snail and E-cadherin expression levels by real time-PCR...
March 13, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28295342/an-information-theory-account-of-late-frontoparietal-erp-positivities-in-cognitive-control
#14
Francisco Barceló, Patrick S Cooper
ERP research on task switching has revealed distinct transient and sustained positive waveforms (latency circa 300-900 ms) while shifting task rules or stimulus-response (S-R) mappings. However, it remains unclear whether such switch-related positivities show similar scalp topography and index context-updating mechanisms akin to those posed for domain-general (i.e., classic P300) positivities in many task domains. To examine this question, ERPs were recorded from 31 young adults (18-30 years) while they were intermittently cued to switch or repeat their perceptual categorization of Gabor gratings varying in color and thickness (switch task), or else they performed two visually identical control tasks (go/no-go and oddball)...
March 15, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28289734/regulatory-mechanisms-of-hsp90
#15
Chrisostomos Prodromou
The ability of Hsp90 to activate a disparate clientele implicates this chaperone in diverse biological processes. To accommodate such varied roles, Hsp90 requires a variety of regulatory mechanisms that are coordinated in order to modulate its activity appropriately. Amongst these, the master-regulator heat shock factor 1 (HSF1) is critically important in upregulating Hsp90 during stress, but is also responsible, through interaction with specific transcription factors (such as STAT1 and Strap/p300) for the integration of a variety of biological signals that ultimately modulate Hsp90 expression...
January 30, 2017: Biochemistry & Molecular Biology Journal
https://www.readbyqxmd.com/read/28288178/can-application-and-transfer-of-strategy-be-observed-in-low-visibility-condition
#16
Imen El Karoui, Kalliopi Christoforidis, Lionel Naccache
It has been long assumed that cognitive control processes can only be applied on consciously visible stimuli, but empirical evidence is contradictory. In the present study, we investigated strategic adaptation to conflict both in unmasked and in low-visibility masked trials. Using a paradigm derived from the Stroop task, we studied the application of strategies, but also the transfer of a strategy developed in unmasked trials to masked trials, and the trial-to-trial dynamics of strategic processing. In unmasked trials, we found evidence of strategic adaptation to conflict, both in reaction times and in ERPs (N2 and P300)...
2017: PloS One
https://www.readbyqxmd.com/read/28287777/n400-and-emotional-word-processing-in-parkinson-s-disease
#17
Nadeeka N W Dissanayaka, Tiffany R Au, Anthony J Angwin, John D O'Sullivan, Gerard J Byrne, Peter A Silburn, Rodney Marsh, George D Mellick, David A Copland
OBJECTIVE: Emotional and cognitive disturbances are common complications in Parkinson's disease (PD). N400 is an event related potential (ERP) strongly linked to lexical-semantic processing and has demonstrated alterations in amplitude and latency when PD patients performed semantic priming tasks. The present study investigated the role of N400 in an automatic affective priming paradigm in PD. Other ERP components relevant to emotion processing were also examined. METHOD: Twenty-two PD patients and 17 healthy adults performed an automatic affective priming task while ERPs were recorded using 128 channels...
March 13, 2017: Neuropsychology
https://www.readbyqxmd.com/read/28287402/hdac6-mediated-acetylation-of-lipid-droplet-binding-protein-cidec-regulates-fat-induced-lipid-storage
#18
Hui Qian, Yuanying Chen, Zongqian Nian, Lu Su, Haoyong Yu, Feng-Jung Chen, Xiuqin Zhang, Wenyi Xu, Linkang Zhou, Jiaming Liu, Jinhai Yu, Luxin Yu, Yan Gao, Hongchao Zhang, Haihong Zhang, Shimin Zhao, Li Yu, Rui-Ping Xiao, Yuqian Bao, Shaocong Hou, Pingping Li, Jiada Li, Haiteng Deng, Weiping Jia, Peng Li
Obesity is characterized by aberrant fat accumulation. However, the intracellular signaling pathway that senses dietary fat and leads to fat storage remains elusive. Here, we have observed that the levels of histone deacetylase 6 (HDAC6) and the related family member HDAC10 are markedly reduced in adipose tissues of obese animals and humans. Mice with adipocyte-specific depletion of Hdac6 exhibited increased fat accumulation and reduced insulin sensitivity. In normal adipocytes, we found that reversal of P300/CBP-associated factor-induced (PCAF-induced) acetylation at K56 on cell death-inducing DFFA-like effector C (CIDEC, also known as FSP27) critically regulated lipid droplet fusion and lipid storage...
March 13, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28286521/pulling-a-ligase-out-of-a-hat-pcaf-mediates-ubiquitination-of-the-class-ii-transactivator
#19
Julie E Morgan, Susanna F Greer
The Class II Transactivator (CIITA) is essential to the regulation of Major Histocompatibility Class II (MHC II) genes transcription. As the "master regulator" of MHC II transcription, CIITA regulation is imperative and requires various posttranslational modifications (PTMs) in order to facilitate its role. Previously we identified various ubiquitination events on CIITA. Monoubiquitination is important for CIITA transactivity, while K63 linked ubiquitination is involved in crosstalk with ERK1/2 phosphorylation, where together they mediate cellular movement from the cytoplasm to nuclear region...
2017: International Journal of Cell Biology
https://www.readbyqxmd.com/read/28285917/examining-the-structure-activity-relationship-of-benzopyran-based-inhibitors-of-the-hypoxia-inducible-factor-1-pathway
#20
Jalisa Ferguson, Zeus De Los Santos, Narra Devi, Erwin Van Meir, Sarah Zingales, Binghe Wang
Many forms of solid tumor have a characteristic feature known as hypoxia, which describes a low or non-existent presence of oxygen in the cellular microenvironment. This decrease in oxygen causes activation of the hypoxia inducible factor (HIF) pathway, which activates the transcription of many genes that cause cell proliferation, metastasis, increased glycolysis and angiogenesis. Increased HIF expression has been linked with poor patient prognosis, increased malignancy, and therapeutic resistance. Previous work in our lab has identified 1 and 2 as inhibitors of the HIF pathway, specifically as disrupters of the p300-HIF-1α complex formation...
March 1, 2017: Bioorganic & Medicinal Chemistry Letters
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