Ying Wen, Yingying Liu, Qiang Li, Jinlin Tan, Xing Fu, Yiwen Liang, Yonghua Tuo, Luhao Liu, Xueqiong Zhou, Dongkai LiuFu, Xuejiao Fan, Chaofei Chen, Zheng Chen, Zhouping Wang, Shunyang Fan, Renjing Liu, Lei Pan, Yuan Zhang, Wai Ho Tang
BACKGROUND: Abdominal aortic aneurysm (AAA) is a catastrophic disease with little effective therapy, likely due to the limited understanding of the mechanisms underlying AAA development and progression. Activating transcription factor (ATF) 3 has been increasingly recognized as a key regulator of cardiovascular diseases. However, the role of ATF3 (activating transcription factor 3) in AAA development and progression remains elusive. METHODS: Genome-wide RNA sequencing analysis was performed on the aorta isolated from saline or Ang II (angiotensin II)-induced AAA mice, and ATF3 was identified as the potential key gene for AAA development...
April 30, 2024: Circulation Research