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https://www.readbyqxmd.com/read/29151101/psychoacoustics-and-neurophysiological-alterations-after-30-36-hours-of-sleep-deprivation
#1
Adrián Poblano, Sergio Díaz-Leines, Olga Gama-Moreno, Blanca Flores-Avalos
BACKGROUND AND AIM: Sleep deprivation (SD) may result in perceptual and cognitive alterations in healthy subjects. Our objective was to compare whether psychoacoustics and neurophysiological variables in healthy subjects were altered after SD of 30-36 h. METHOD: We examined 22 subjects by means of several psychoacoustics tests, P300 and mismatch negativity (MMN) recordings, and brainstem auditory evoked potentials (BAEP) before and after 30-36 h of SD. RESULTS: In the psychoacoustics tests, we found that after SD, difficulties were experienced by the left ear in the discrimination of words in noise and by the right ear in music discrimination...
November 18, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/29150847/chronic-sun-exposure-is-associated-with-distinct-histone-acetylation-changes-in-human-skin
#2
S Ding, J Chen, Q Zeng, J Lu, L Tan, A Guo, J Kang, S Yang, Y Xiang, C Zuo, J Huang
BACKGROUND: Photoaging is attributed to continuous sunlight or artificial UV exposure and manifests the clinical and histological changes of skin. Epigenetic changes have been found to be involved in the pathogenesis of photoaging. However, the underlying mechanisms are unclear. OBJECTIVES: To analyse histone modification patterns in sun-exposed and non-exposed skins, and identify the abnormally histone modified-genes related to photoaging. METHODS: Skin biopsies were collected both from the outer forearm (sun-exposed area) and the buttock (sun-protected area) in 20 healthy middle-aged female volunteers...
November 18, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29150430/interferon-%C3%A1%C2%B5-2-signaling-in-melanocytes-and-melanoma-cells-regulates-expression-of-ctla-4
#3
Xuan Mo, Hanghang Zhang, Sarah Preston, Kayla Martin, Bo Zhou, Nish Vadalia, Ana M Gamero, Jonathan Soboloff, Italo Tempera, M Raza Zaidi
CTLA-4 is a cell surface receptor on T cells that functions as an immune checkpoint molecule to enforce tolerance to cognate antigens. Anti-CTLA-4 immunotherapy is highly effective at reactivating T cell responses against melanoma, which is postulated to be due to targeting CTLA-4 on T cells. Here we report that CTLA-4 is also highly expressed by most human melanoma cell lines, as well as in normal human melanocytes. Interferon-gamma (IFNG) signaling activated the expression of the human CTLA-4 gene in a melanocyte and melanoma cell-specific manner...
November 17, 2017: Cancer Research
https://www.readbyqxmd.com/read/29148150/pressure-flow-characteristics-of-breathing-systems-and-their-components-for-pediatric-and-adult-patients
#4
Christin Wenzel, Stefan Schumann, Johannes Spaeth
BACKGROUND: Breathing circuits connect the ventilator to the patients' respiratory system. Breathing tubes, connectors, and sensors contribute to artificial airway resistance to a varying extent. We hypothesized that the flow-dependent resistance is higher in pediatric breathing systems and their components compared to respective types for adults. AIMS: We aimed to characterize the resistance of representative breathing systems and their components used in pediatric patients (including devices for adults) by their nonlinear pressure-flow relationship...
November 17, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29145650/loss-of-p300-and-cbp-disrupts-histone-acetylation-at-the-mouse-sry-promoter-and-causes-xy-gonadal-sex-reversal
#5
Gwenn-Aël Carré, Pam Siggers, Marilena Xipolita, Paul Brindle, Beat Lutz, Sara Wells, Andy Greenfield
CREB-binding protein (CBP, CREBBP, KAT3A) and its closely related paralogue p300 (EP300, KAT3B), together termed p300/CBP, are histone/lysine acetyl-transferases that control gene expression by modifying chromatin-associated proteins. Here, we report roles for both of these chromatin-modifying enzymes in mouse sex determination, the process by which the embryonic gonad develops into a testis or an ovary. By targeting gene ablation to embryonic gonadal somatic cells using an inducible Cre line, we show that gonads lacking either gene exhibit major abnormalities of XY gonad development at 14...
November 14, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29142126/hpv-replication-regulation-by-acetylation-of-a-conserved-lysine-in-the-e2-protein
#6
Yanique Thomas, Elliot J Androphy
The Papillomavirus (PV) E2 protein is a sequence specific DNA binding protein that recruits cellular factors to its genome in infected epithelial cells. E2 also binds to and loads the viral E1 DNA helicase at the origin of replication. Post-translational modifications (PTMs) of PV E2 have been identified as potential regulators E2 functions. We recently reported lysine (K) 111 as a target of p300 acetylation in bovine (B)PV. The di-lysines at 111 and 112 are conserved in almost all papillomaviruses. We pursued a mutational approach to query the functional significance of lysine in human (H)PV E2...
November 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29141987/brachyury-directs-histone-acetylation-to-target-loci-during-mesoderm-development
#7
Arica Beisaw, Pavel Tsaytler, Frederic Koch, Sandra U Schmitz, Maria-Theodora Melissari, Anna D Senft, Lars Wittler, Tracie Pennimpede, Karol Macura, Bernhard G Herrmann, Phillip Grote
T-box transcription factors play essential roles in multiple aspects of vertebrate development. Here, we show that cooperative function of BRACHYURY (T) with histone-modifying enzymes is essential for mouse embryogenesis. A single point mutation (T(Y88A)) results in decreased histone 3 lysine 27 acetylation (H3K27ac) at T target sites, including the T locus, suggesting that T autoregulates the maintenance of its expression and functions by recruiting permissive chromatin modifications to putative enhancers during mesoderm specification...
November 15, 2017: EMBO Reports
https://www.readbyqxmd.com/read/29139557/using-somatosensory-mismatch-responses-as-a-window-into-somatotopic-processing-of-tactile-stimulation
#8
Guannan Shen, Nathan J Smyk, Andrew N Meltzoff, Peter J Marshall
Brain responses to tactile stimulation have often been studied through the examination of ERPs elicited to touch on the body surface. Here, we examined two factors potentially modulating the amplitude of the somatosensory mismatch negativity (sMMN) and P300 responses elicited by touch to pairs of body parts: (a) the distance between the representation of these body parts in somatosensory cortex, and (b) the physical distances between the stimulated points on the body surface. The sMMN and the P300 response were elicited by tactile stimulation in two oddball protocols...
November 15, 2017: Psychophysiology
https://www.readbyqxmd.com/read/29138297/mafb-enhances-oncogenic-notch-signaling-in-t-cell-acute-lymphoblastic-leukemia
#9
Kostandin V Pajcini, Lanwei Xu, Lijian Shao, Jelena Petrovic, Karol Palasiewicz, Yumi Ohtani, Will Bailis, Curtis Lee, Gerald B Wertheim, Rajeswaran Mani, Natarajan Musuthamy, Yunlei Li, Jules P P Meijerink, Stephen C Blacklow, Robert B Faryabi, Sara Cherry, Warren S Pear
Activating mutations in the gene encoding the cell-cell contact signaling protein Notch1 are common in human T cell acute lymphoblastic leukemias (T-ALLs). However, expressing Notch1 mutant alleles in mice fails to efficiently induce the development of leukemia. We performed a gain-of-function screen to identify proteins that enhanced signaling by leukemia-associated Notch1 mutants. The transcription factors MAFB and ETS2 emerged as candidates that individually enhanced Notch1 signaling, and when coexpressed, they synergistically increased signaling to an extent similar to that induced by core components of the Notch transcriptional complex...
November 14, 2017: Science Signaling
https://www.readbyqxmd.com/read/29137031/subcellular-localization-of-%C3%AE-arrestin1-and-its-prognostic-value-in-lung-adenocarcinoma
#10
Xiaowei Li, Keying Che, Liguang Wang, Tiehong Zhang, Guanghui Wang, Zhaofei Pang, Hongchang Shen, Jiajun Du
β-Arrestins play important roles in cancer progression, and the subcellular localization of β-arrestin1 has been receiving increasingly more attention. Intriguingly, several studies, including some of our previous work, showed that the effects of β-arrestin1 on outcomes of cancer patients were controversial.Specimens were obtained from 133 patients with lung adenocarcinoma. Immunohistochemistry was used to detect the expression of β-arrestin1 and p300 in the collected tissues. The Kaplan-Meier analysis and Cox proportional hazards regression were used to examine the relationship between β-arrestin1 and patient survival...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29134296/p300-based-acuity-estimation-in-imitated-amblyopia
#11
Marvin L Beusterien, Sven P Heinrich
PURPOSE: A frequent approach to estimating visual acuity objectively is the recording of visual evoked potentials (VEPs) to patterns of different coarseness. This, however, overestimates acuity in patients with fragmented and distorted vision such as in amblyopia. This is likely due to VEP-based techniques using checkerboard or grating stimuli. We hypothesized that no overestimation would occur when the event-related potential P300 in response to optotype stimuli is used for acuity estimation...
November 13, 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/29118015/anril-regulates-production-of-extracellular-matrix-proteins-and-vasoactive-factors-in-diabetic-complications
#12
Anu Alice Thomas, Biao Feng, Subrata Chakrabarti
Long non-coding RNAs (lncRNAs) have gained widespread interest due to their prevailing presence in various diseases. lncRNA ANRIL (a.k.a CDKN2B-AS1) is located on human chromosome 9 (p21.3) and transcribed in opposite direction to INK4b-ARF-INK4a gene cluster. It has been identified as highly susceptible region for diseases such as coronary artery diseases and Type 2 Diabetes. Here we explored its regulatory role in diabetic nephropathy (DN) and diabetic cardiomyopathy (DCM) in association with epigenetic modifiers p300 and polycomb repressive complex 2 (PRC2) complex...
November 7, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29115418/predicting-pathogenic-genes-for-primary-myelofibrosis-based-on-a-system%C3%A2-network-approach
#13
Shu-Cai Xu, Peng Ning
The aim of the present study was to predict pathogenic genes for primary myelofibrosis (PMF) using a system‑network approach by combining protein‑protein interaction (PPI) network and gene expression data with known pathogenic genes. PMF gene expression profiles, known pathogenic genes and protein‑protein interactions were obtained. Using these data, differentially expressed genes (DEGs) were identified between PMF and normal conditions using significance analysis of microarrays, and seed genes were determined based on the intersection of known pathogenic genes and the PMF gene expression profile...
October 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29115376/ccdc134-serves-a-crucial-role-in-embryonic-development
#14
Biaoyi Yu, Tianzhuo Zhang, Peng Xia, Xiaoting Gong, Xiaoyan Qiu, Jing Huang
Coiled-coil domain containing 134 (CCDC134), a characterized secreted protein, may serve as an immune cytokine and illustrates its potent antitumor effects by augmenting CD8+ T-cell-mediated immunity. Additionally, CCDC134 may also act as a novel regulator of human alteration/deficiency in activation 2a, and be involved in the p300-CBP-associated factor complex and affect its acetyltransferase activity. To clarify the biological and pathological function of CCDC134, the present study generated a viable and fertile Ccdc134fl/fl mouse strain that allowed temporal and spatial control of gene ablation...
October 19, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29111453/electrophysiological-correlates-of-near-outcome-and-outcome-sequence-processing-in-problem-gamblers-and-controls
#15
Natalie Ulrich, Johannes Hewig
The magnification of skill component in gambling as well as the gambler's and hot hand fallacies are gambling-related cognitive distortions. The magnification of skill component refers to the belief that one's ability can be used to win in gambling and that there is a reliable way to do so. The gambler's fallacy refers to the belief that a given outcome is unlikely to follow a preceding run of the same outcome (e.g. a coin coming up heads following a run of heads), while the hot hand fallacy refers to the belief that a streak of wins is going to continue...
October 27, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29111275/morphine-delays-neural-stem-cells-differentiation-by-facilitating-nestin-overexpression
#16
Ada Jimenez-Gonzalez, Adrián García-Concejo, Fernando León-Lobera, Raquel E Rodriguez
BACKGROUND: Morphine is used as an analgesic although it causes important secondary effects. These effects are triggered by several mechanisms leading to the dysregulation of gene expression. Here we aimed to study these alterations on neural stem cells (NSC) during CNS development. METHODS: AB strain and tg nestin:GFP zebrafish embryos, zebrafish primary neuron culture and mouse embryonic stem cells were used to assess the effect of morphine by qPCR, time lapse microscopy and western blot...
October 27, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29107659/is-this-blood-an-erp-study-on-the-visual-identification-of-red-fluids-in-patients-with-blood-phobia
#17
Verena Leutgeb, Daniela Schwab, Wilfried Scharmüller, Carina Höfler, Anne Schienle
Blood can be easily recognized in situations involving injury. However, very little is known about the ability of humans to identify blood without such context information. We investigated the blood detection capacity and associated electrocortical correlates (event-related potentials) in 20 women with blood phobia and 20 non-phobic females. The participants viewed images depicting droplets of pig blood, and water with pink or red food coloring. They were asked to decide, whether the pictures showed real blood or not...
October 28, 2017: Brain Research
https://www.readbyqxmd.com/read/29101234/periodic-variation-in-bile-acids-controls-circadian-changes-in-uric-acid-via-regulation-of-xanthine-oxidase-by-the-orphan-nuclear-receptor-ppar%C3%AE
#18
Takumi Kanemitsu, Yuya Tsurudome, Naoki Kusunose, Masayuki Oda, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo
Xanthine oxidase (XOD), also known as xanthine dehydrogenase, is a rate-limiting enzyme in purine nucleotide degradation, which produces uric acid. Uric acid concentrations in the blood and liver exhibit circadian oscillations in both humans and rodents; however, the underlying mechanisms remain unclear. Here, we demonstrate that XOD expression and enzymatic activity exhibit circadian oscillations in the mouse liver. The orphan nuclear receptor peroxisome proliferator-activated receptor-α (PPARα) transcriptionally activates the mouse XOD gene and that bile acids suppresses the XOD transactivation...
November 3, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29100212/an-event-related-potential-investigation-of-the-acute-effects-of-aerobic-and-coordinative-exercise-on-inhibitory-control-in-children-with-adhd
#19
Sebastian Ludyga, Serge Brand, Markus Gerber, Peter Weber, Mark Brotzmann, Fahimeh Habibifar, Uwe Pühse
The current body of evidence suggests that an aerobic exercise session has a beneficial effect on inhibitory control, whereas the impact of coordinative exercise on this executive function has not yet been examined in children with ADHD. Therefore, the present study aims to investigate the acute effects of aerobic and coordinative exercise on behavioral performance and the allocation of attentional resources in an inhibitory control task. Using a cross-over design, children with ADHD-combined type and healthy comparisons completed a Flanker task before and after 20min moderately-intense cycling exercise, coordinative exercise and an inactive control condition...
October 27, 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/29099917/cbp-1-acts-in-gabaergic-neurons-to-double-lifespan-in-axenically-cultured-c-elegans
#20
Huaihan Cai, Ineke Dhondt, Lieselot Vandemeulebroucke, Caroline Vlaeminck, Madina Rasulova, Bart P Braeckman
When cultured in axenic medium, C. elegans shows the largest lifespan extension compared to other dietary restriction regimens. However, the underlying molecular mechanism still remains elusive. The gene cbp-1, encoding the worm ortholog of p300/CBP (CREB-binding protein), is one of the very few key genes known to be essential for lifespan doubling under axenic dietary restriction (ADR). By using tissue-specific RNAi, we found that cbp-1 expression in the germline is essential for fertility whereas this gene functions specifically in the GABAergic neurons to support the full lifespan-doubling effect of ADR...
November 1, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
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