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Biomedical chemistry

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https://www.readbyqxmd.com/read/28533376/b12-dependent-photoresponsive-protein-hydrogels-for-controlled-stem-cell-protein-release
#1
Ri Wang, Zhongguang Yang, Jiren Luo, I-Ming Hsing, Fei Sun
Thanks to the precise control over their structural and functional properties, genetically engineered protein-based hydrogels have emerged as a promising candidate for biomedical applications. Given the growing demand for creating stimuli-responsive "smart" hydrogels, here we show the synthesis of entirely protein-based photoresponsive hydrogels by covalently polymerizing the adenosylcobalamin (AdoB12)-dependent photoreceptor C-terminal adenosylcobalamin binding domain (CarHC) proteins using genetically encoded SpyTag-SpyCatcher chemistry under mild physiological conditions...
May 22, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28532078/enhancement-of-fibroblast-growing-on-the-mannosylated-surface-of-cellulose-membranes
#2
Simone Birkheur, Paula Cristina de Sousa Faria-Tischer, Cesar A Tischer, Elisângela Flávia Pimentel, Marcio Fronza, Denise Coutinho Endringer, Anna Paola Butera, Renato Márcio Ribeiro-Viana
Bacterial cellulose membrane is a biomaterial with high value in the biomedical field. Many groups have been making efforts to promote chemical modifications of its structure and, consequently, add new characteristics. Recently, our group has developed a methodology to insert monoester succinic acid in bacterial cellulose membrane without disrupting the microfibril network and bind a protein on it. Considering the role of carbohydrates in the molecular recognition process in biological events, we continued these studies by inserting covalently multiples copies of aryl monosaccharide to bacterial cellulose succinylated and to study the in vitro tissue compatibility using fibroblasts...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531195/livestock-metabolomics-and-the-livestock-metabolome-a-systematic-review
#3
Seyed Ali Goldansaz, An Chi Guo, Tanvir Sajed, Michael A Steele, Graham S Plastow, David S Wishart
Metabolomics uses advanced analytical chemistry techniques to comprehensively measure large numbers of small molecule metabolites in cells, tissues and biofluids. The ability to rapidly detect and quantify hundreds or even thousands of metabolites within a single sample is helping scientists paint a far more complete picture of system-wide metabolism and biology. Metabolomics is also allowing researchers to focus on measuring the end-products of complex, hard-to-decipher genetic, epigenetic and environmental interactions...
2017: PloS One
https://www.readbyqxmd.com/read/28521100/single-step-synthesis-of-small-azide-functionalized-gold-nanoparticles-versatile-water-dispersible-reagents-for-click-chemistry
#4
Edward W Elliott, Aurora L Ginzburg, Zachary C Kennedy, Zhenshuo Feng, James E Hutchison
Nanoparticles possessing functional groups that can be readily conjugated (e.g. through click chemistry) are important precursors for the preparation of customized nanohybrid products. Such nanoparticles, if they are stable against agglomeration, are easily dispersible and have well-defined surface chemistry and size. As click-ready reagents, they can be stored until their time of use and then simply dispersed and reacted with an appropriate substrate. Gold nanoparticles (AuNPs) are excellent candidates for this purpose and some clickable gold nanoparticles have been developed; however, AuNPs for use in aqueous systems are often prepared through difficult multistep processes and/or can be poorly dispersible in water...
May 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28520407/controlling-configurational-isomerism-in-three-component-colloidal-hybrid-nanoparticles
#5
James M Hodges, Raymond E Schaak
Colloidal hybrid nanoparticles are solution-dispersible constructs that join together multiple distinct nanoscale materials through direct solid-solid interfaces. Given their multifunctionality and synergistic properties that emerge from interfacial coupling, hybrid nanoparticles are of interest for applications in biomedical imaging, solar energy conversion, heterogeneous catalysis, nanophotonics, and beyond. High-order hybrid nanoparticles, which incorporate three or more nanocrystal domains, offer greater tunability and functional diversity relative to one or two-component nanoparticles...
May 18, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28505596/engineered-hydrogels-increase-the-post-transplantation-survival-of-encapsulated-hesc-derived-midbrain-dopaminergic-neurons
#6
Maroof M Adil, Tandis Vazin, Badriprasad Ananthanarayanan, Gonçalo M C Rodrigues, Antara T Rao, Rishikesh U Kulkarni, Evan W Miller, Sanjay Kumar, David V Schaffer
Cell replacement therapies have broad biomedical potential; however, low cell survival and poor functional integration post-transplantation are major hurdles that hamper clinical benefit. For example, following striatal transplantation of midbrain dopaminergic (mDA) neurons for the treatment of Parkinson's disease (PD), only 1-5% of the neurons typically survive in preclinical models and in clinical trials. In general, resource-intensive generation and implantation of larger numbers of cells are used to compensate for the low post-transplantation cell-survival...
May 5, 2017: Biomaterials
https://www.readbyqxmd.com/read/28497789/underwater-leidenfrost-nanochemistry-for-creation-of-size-tailored-zinc-peroxide-cancer-nanotherapeutics
#7
Mady Elbahri, Ramzy Abdelaziz, Duygu Disci-Zayed, Shahin Homaeigohar, Justyna Sosna, Dieter Adam, Lorenz Kienle, Torben Dankwort, Moheb Abdelaziz
The dynamic underwater chemistry seen in nature is inspiring for the next generation of eco-friendly nanochemistry. In this context, green synthesis of size-tailored nanoparticles in a facile and scalable manner via a dynamic process is an interesting challenge. Simulating the volcano-induced dynamic chemistry of the deep ocean, here we demonstrate the Leidenfrost dynamic chemistry occurring in an underwater overheated confined zone as a new tool for customized creation of nanoclusters of zinc peroxide. The hydrodynamic nature of the phenomenon ensures eruption of the nanoclusters towards a much colder region, giving rise to growth of monodisperse, size-tailored nanoclusters...
May 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/28496523/probing-the-causes-of-thermal-hysteresis-using-tunable-nagg-micelles-with-linear-and-brush-like-thermoresponsive-coronas
#8
L D Blackman, M I Gibson, R K O'Reilly
Self-assembled thermoresponsive polymers in aqueous solution have great potential as smart, switchable materials for use in biomedical applications. In recent years, attention has turned to the reversibility of these polymers' thermal transitions, which has led to debate over what factors influence discrepancies in the transition temperature when heating the system compared to the temperature obtained when cooling the system, known as the thermal hysteresis. Herein, we synthesize micelles with tunable aggregation numbers (Nagg) whose cores contain poly(n-butyl acrylate-co-N,N-dimethylacrylamide) (p(nBA-co-DMA)) and four different thermoresponsive corona blocks, namely poly(N-isopropylacrylamide) (pNIPAM), poly(N,N-diethylacrylamide) (pDEAm), poly(diethylene glycol monomethyl ether methacrylate) (pDEGMA) and poly(oligo(ethylene glycol) monomethyl ether methacrylate) (pOEGMA)...
January 1, 2017: Polymer Chemistry
https://www.readbyqxmd.com/read/28494152/low-temperature-synthesis-of-carbon-rich-nanoparticles-with-clickable-surface-for-functionalization
#9
Audrey Picard-Lafond, Jean-Francois Morin
Carbon nanoparticles (CNPs) are promising materials for optoelectronic and biomedical applications thanks to their optical properties, low production cost, and superior biocompatibility compared to traditional semi-conductor quantum dots. The countless synthetic methods reported allow a library of diverse CNPs structures and optical properties, guiding their subsequent applications. However, the current drawbacks lie mainly within these synthetic processes, as many of them require harsh conditions preventing control over morphology and often generating chemically inert nanoparticles...
May 11, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28489410/strategically-designing-a-pumpless-microfluidic-device-on-an-inert-polypropylene-substrate-with-potential-application-in-biosensing-and-diagnostics
#10
Elham Shirani, Amir Razmjou, Hossein Tavassoli, Amir Landarani-Isfahani, Saghar Rezaei, Abolghasem Abbasi Kajani, Mohsen Asadnia, Jingwei Hou, Majid Ebrahimi Warkiani
This study is an attempt to make a step forward to implement the very immature concept of pumpless transportation of liquid into a real miniaturized device or lab-on-chip (LOC) on a plastic substrate. "Inert" plastic materials such as polypropylene (PP) are used in a variety of biomedical applications but their surface engineering is very challenging. Here, it was demonstrated that with a facile innovative wettability patterning route using fluorosilanized UV-independent TiO2 nanoparticle coating it is possible to create wedge-shaped open microfluidic tracks on inert solid surfaces for low-cost biomedical devices (lab-on-plastic)...
May 22, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28481537/designing-peptide-and-protein-modified-hydrogels-selecting-the-optimal-conjugation-strategy
#11
Stephanie A Fisher, Alexander E G Baker, Molly S Shoichet
Hydrogels are used in a wide variety of biomedical applications including tissue engineering, biomolecule delivery, cell delivery, and cell culture. These hydrogels are often designed with a specific biological function in mind, requiring the chemical incorporation of bioactive factors to either mimic extracellular matrix or to deliver a payload to diseased tissue. Appropriate synthetic techniques to ligate bioactive factors, such as peptides and proteins, onto hydrogels are critical in designing materials with biological function...
May 8, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28480714/nanoparticle-protein-interactions-therapeutic-approaches-and-supramolecular-chemistry
#12
Mathis Kopp, Sebastian Kollenda, Matthias Epple
Research on nanoparticles has evolved into a major topic in chemistry. Concerning biomedical research, nanoparticles have decisively entered the field, creating the area of nanomedicine where nanoparticles are used for drug delivery, imaging, and tumor targeting. Besides these functions, scientists have addressed the specific ways in which nanoparticles interact with biomolecules, with proteins being the most prominent example. Depending on their size, shape, charge, and surface functionality, specifically designed nanoparticles can interact with proteins in a defined way...
May 8, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28477379/tolyporphin-an-unusual-green-chlorin-like-dioxobacteriochlorin
#13
Christian Brückner
The tolyporphins, a family of green tetrapyrrolic pigments isolated from a cyanobacterium-microbial ecological unit, possess unique carbohydrate-derivatized dioxobacteriochlorin frameworks. A brief overview over the history, synthesis, chemistry, and biological properties of the tolyporphins form the backdrop for highlighting the contribution by Hood et al. [Hood, D., D. M. Niedzwiedzki, R. Zhang, Y. Zhang, J. Dai, E. S. Miller, D. F. Bocian, P. G. Williams, J. S. Lindsey and D. Holten (2017) Photochem. Photobiol...
May 6, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28468500/physical-chemistry-in-biomedical-research-from-cuvettes-toward-cellular-insights
#14
Jessica D Flynn, Jennifer C Lee
No abstract text is available yet for this article.
May 4, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28466898/enhanced-antibacterial-efficacy-of-nitric-oxide-releasing-thermoplastic-polyurethanes-with-antifouling-hydrophilic-topcoats
#15
Priyadarshini Singha, Jitendra Pant, Marcus J Goudie, Christina D Workman, Hitesh Handa
Surface fouling is one of the leading causes of infection associated with implants, stents, catheters, and other medical devices. The surface chemistry of medical device coatings is important in controlling and/or preventing fouling. In this study, we have shown that a combination of nitric oxide releasing hydrophobic polymer with a hydrophilic polymer topcoat can significantly reduce protein attachment and subsequently reduce bacterial adhesion as a result of the synergistic effect. Nitric oxide (NO) is a well-known potent antibacterial agent due to its adverse reactions on microbial cell components...
May 3, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28451194/modulating-the-phases-of-iron-carbide-nanoparticles-from-a-perspective-of-interfering-with-the-carbon-penetration-of-fe-fe3o4-by-selectively-adsorbed-halide-ions
#16
Ziyu Yang, Tianshan Zhao, Xiaoxiao Huang, Xin Chu, Tianyu Tang, Yanmin Ju, Qian Wang, Yanglong Hou, Song Gao
Iron carbide nanoparticles (ICNPs) are considered to have great potential in new energy conversion, nanomagnets and biomedical applications due to their intrinsically peculiar magnetic and catalytic properties. However, the synthetic routes were greatly limited in morphology and phase controlled synthesis. In this article, we present a versatile solution chemistry route towards colloidal ICNPs (Fe2C-hexagonal and monoclinic syngony, Fe5C2-monoclinic syngony and Fe3C-orthorhombic syngony) derived from body centered cubic Fe@Fe3O4 by introducing heteroatoms to restrain their phase transformation...
January 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28445804/nanoencapsulation-of-individual-mammalian-cells-with-cytoprotective-polymer-shell
#17
Jianmin Yang, Jingchao Li, Xiaomeng Li, Xinlong Wang, Yingjun Yang, Naoki Kawazoe, Guoping Chen
Nanoencapsulation of individual mammalian cells has great potential in biomedical, biotechnological and bioelectronic applications. However, existing techniques for cell nanoencapsulation generally yield short sustaining period and loose structure of encapsulation shell, which fails to meet the long-term cytoprotection and immunosuppression requirements. Here, we report a mild method to realize the nanoencapsulation of individual mammalian cells by layer-by-layer (LbL) assembly of gelatin inner layer and cross-linking of poly(ethylene glycol) (PEG) outer layer through thiol-click chemistry...
April 18, 2017: Biomaterials
https://www.readbyqxmd.com/read/28443929/construction-of-protein-assemblies-by-host-guest-interactions-with-cucurbiturils
#18
REVIEW
Chunxi Hou, Zupeng Huang, Yu Fang, Junqiu Liu
Protein assemblies are extremely interesting in chemistry and supramolecular chemistry. How to design protein assemblies with dimensional structures is important for applications. To address this challenge, cucurbituril (CB[n]s)-based strategies have been explored owing to their high affinity toward small peptide motifs, organic cations and amines. By incorporation of a small molecule guest and a peptide motif guest into N-terminals of oligomeric proteins, CB[n]s could recognize and bind to the N-terminal guests, leading to dimensional protein assemblies...
May 23, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28438041/design-of-multifunctional-liposome-quantum-dot-hybrid-nanocarriers-and-their-biomedical-application
#19
Wenjing Qu, Wenbao Zuo, Na Li, Yanhui Hou, Zhihua Song, Guojing Gou, Jianhong Yang
Luminescent semiconductor nanocrystals, also known as quantum dots (QDs), have rich surface chemistry and unique optical properties that make them useful as probes or carriers for molecular diagnostics and therapeutics. However, their potential toxicity and instability in biological environments have puzzled scientific researchers. Much research effort has been devoted to encapsulation of QDs with liposomal hybrids to make them versatile nanocarriers for simultaneous therapeutics and diagnostics (theranostics) and considerable progress has been made over recent years...
May 8, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28433992/the-aachen-minipig-phenotype-genotype-hematological-and-biochemical-characterization-and-comparison-to-the-g%C3%A3-ttingen-minipig
#20
Kerstin Pawlowsky, Lisa Ernst, Julia Steitz, Thaddäus Stopinski, Babette Kögel, Anna Henger, Reinhart Kluge, René Tolba
BACKGROUND: The pig is one of the most frequently used large animal models for biomedical research, especially in the field of translational research and surgical models. While standard livestock breeds are used in short-term and acute studies, minipig breeds are the preferred breeds in long-term and chronic studies due to their limited growth and body weight. OBJECTIVE: In consideration of the 3R principle (refinement, reduction, replacement) and the increasing demand, the aim of this study was to generate a new, robust, non-specific-pathogen-free minipig breed, the Aachen minipig...
April 22, 2017: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
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