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Biomedical chemistry

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https://www.readbyqxmd.com/read/28816400/silica-modified-luminescent-lapo4-eu-lapo4-sio2-core-shell-nanorods-synthesis-structural-and-luminescent-properties
#1
Anees A Ansari
Monoclinic-type tetragonal LaPO4 :Eu (core) and LaPO4 :Eu@LaPO4 (core/shell) nanorods (NRs) were successfully prepared using a urea-based co-precipitation process under ambient conditions. An amorphous silica layer was coated around the luminescent core/shell NRs via the sol-gel process to improve their solubility and colloidal stability in aqueous and non-aqueous media. The prepared nano-products were systematically characterized by X-ray diffraction pattern, transmission electron microscopy, energy dispersive X-ray analysis, and FTIR, UV/Vis, and photoluminescence spectroscopy to examine their phase purity, crystal phase, surface chemistry, solubility and luminescence characteristics...
August 17, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/28813592/3d-printed-phema-materials-for-topographical-and-biochemical-modulation-of-dorsal-root-ganglion-cell-response
#2
Adina Badea, Joselle M McCracken, Emily G Tillmaand, Mikhail Eugene Kandel, Aaron W Oraham, Molly B Mevis, Stanislav S Rubakhin, Gabriel Popescu, Jonathan V Sweedler, Ralph G Nuzzo
Understanding and controlling the interactions occurring between cells and engineered materials are central challenges towards progress in the development of biomedical devices. In this work, we describe materials for direct ink writing (DIW), an extrusion-based type of 3D printing, that embed a custom synthetic protein (RGD-PDL) within the microfilaments of 3D-hydrogel scaffolds to modify these interactions and differentially direct tissue-level organization of complex cell populations in vitro. The RGD-PDL is synthesized by modifying poly-ᴅ-lysine (PDL) to varying extents with peptides containing the integrin-binding motif Arg-Gly-Asp (RGD)...
August 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28809538/dynamic-covalent-hydrogels-for-triggered-cell-capture-and-release
#3
Fatemeh Karimi, Joe Collins, Daniel E Heath, Luke A Connal
A dual-responsive, cell capture and release surface was prepared through the incorporation of phenylboronic acid (PBA) groups into an oxime-based polyethylene glycol (PEG) hydrogel. Owing to its PEG-like properties, the unfunctionalized hydrogel was non-fouling. The use of the highly efficient oxime-click chemistry allows for the facile incorporation of commercially available 3,5-diformylphenyl boronic acid into the hydrogel matrix. Thus, the surface properties of the hydrogel were modified to enable reversible cell capture and release...
August 15, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28804798/probing-biological-redox-chemistry-with-large-amplitude-fourier-transformed-ac-voltammetry
#4
Hope Adamson, Alan M Bond, Alison Parkin
Biological electron-exchange reactions are fundamental to life on earth. Redox reactions underpin respiration, photosynthesis, molecular biosynthesis, cell signalling and protein folding. Chemical, biomedical and future energy technology developments are also inspired by these natural electron transfer processes. Further developments in techniques and data analysis are required to gain a deeper understanding of the redox biochemistry processes that power Nature. This review outlines the new insights gained from developing Fourier transformed ac voltammetry as a tool for protein film electrochemistry...
August 14, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28795495/thiol-ene-click-reaction-as-a-facile-and-general-approach-for-surface-functionalization-of-colloidal-nanocrystals
#5
Bin Liu, Xiaoran Deng, Zhongxi Xie, Ziyong Cheng, Piaoping Yang, Jun Lin
Oleic acid (OA) and/or oleylamine (OAm) are generally used as the surface ligands for stabilization of inorganic nanocrystals (NCs). The hydrophobic and inert surface of the NCs limits their applications such as in biomedical areas. Hence, surface modifications are essential in many physical and chemical processes. Here, a facile and versatile strategy is reported for the modification of NCs by ultraviolet-induced thiol-ene chemistry, in which thiol-terminated poly(ethylene glycol) (HSPEG) and its derivatives can react directly with double bonds in OA/OAm ligands to form covalent linking within one step...
August 10, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28792052/asymmetric-synthesis-of-%C3%AE-deuterated-%C3%AE-amino-acids
#6
Ryosuke Takeda, Hidenori Abe, Norio Shibata, Hiroki Moriwaki, Kunisuke Izawa, Vadim A Soloshonok
α-Deuterated-α-amino acids represent a very special class of stable isotopically labeled compounds, used in advanced biomedical research. Herein, we disclose a generalized approach for the preparation of α-(2)H-α-amino acids in enantiomerically pure form and with up to 99% deuteration. The reaction chemistry involved in this process is based on the dynamic kinetic resolution of racemates or (S)-(R) interconversion via the formation of intermediate Ni(ii) complexes derived from unprotected amino acids and recyclable tridentate ligands...
August 9, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28771959/antibacterial-activity-and-cytotoxycity-of-gelatine-conjugated-lysine-based-peptides
#7
Maja Kaisersberger Vincek, Amram Mor, Selestina Gorgieva, Vanja Kokol
The effect of the coupling approach (chemical by using carbodiimide chemistry, and enzymatic by using transglutaminase) of a hydrophilic ε-poly-L-lysine (εPL) and a structurally-hydrophobic oligo-acyl-lysyl (OAK) to a gelatine (GEL) macromolecule, and their antibacterial activity against Gram-negative E. coli and Gram-positive S. aureus bacteria, as well as cytotoxicity to human osteoblast cells was studied as potential macromolecules for biomedical applications. Different spectroscopic (ultraviolet-visible, infrared, fluorescence, and electron paramagnetic resonance) and separation (size-exclusion chromatography and capillary zone electrophoresis) techniques, as well as zeta-potential analysis were performed to confirm the εPL/OAK covalent coupling and to determine their amount and orientation of the immobilization...
August 2, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28770494/cell-microencapsulation-in-polyethylene-glycol-hydrogel-microspheres-using-electrohydrodynamic-spraying
#8
Mozhdeh Imaninezhad, Era Jain, Silviya Petrova Zustiak
Microencapsulation of cells is beneficial for various biomedical applications, such as tissue regeneration and cell delivery. While a variety of techniques can be used to produce microspheres, electrohydrodynamic spraying (EHS) has shown promising results for the fabrication of cell-laden hydrogel microspheres in a wide range of sizes and in a relatively high-throughput manner. Here we describe an EHS technique for the fabrication of cell-laden polyethylene glycol (PEG) microspheres. We utilize mild hydrogel gelation chemistry and a combination of EHS parameters to allow for cell microencapsulation with high efficiency and viability...
August 3, 2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28763076/-study-plan-2016-of-the-licentiate-of-medical-surgery-of-the-faculty-of-higher-studies-iztacala
#9
Adolfo René Méndez-Cruz, Xavier de Jesús Novales-Castro, Lilia Isabel Ramírez-García, Eugenio Camarena-Ocampo, Julia Reyes-Reali, Uriel Calderón-Abundes, Dante Amato
The 2016 undergraduate medical degree curriculum at the Facultad de Estudios Superiores Iztacala of the Universidad Nacional Autónoma de México (UNAM) is presented. It is the result of a long institutional reflection and academic dialog process of approximately three years, which culminated in its approval by UNAM's Academic Council for the Biology, Chemistry, and Health Sciences areas on January 25, 2016. Its most relevant characteristics are: modular organization, four knowledge areas (biomedical, methodological, socio-psychological, and humanistic and medical practice), and new modules such as Seminar of socio-psycho-biological integration; Genetics and molecular biology; Biochemistry and cellular biology; Pharmacological basis of therapeutics; Infectious diseases, microbiology and parasitology; Medical ethics; Public health; and Evidence-based medicine - clinical epidemiology...
May 2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/28762718/3d-printing-polymers-with-supramolecular-functionality-for-biological-applications
#10
Allison M Pekkanen, Ryan J Mondschein, Christopher Bryant Williams, Timothy E Long
Supramolecular chemistry continues to experience widespread growth, as fine-tuned chemical structures lead to well-defined bulk materials. Previous literature described the roles of hydrogen bonding, ionic aggregation, guest/host interactions and π-π stacking to tune mechanical, viscoelastic, and processing performance. The versatility of reversible interactions enables the more facile manufacturing of molded parts with tailored hierarchical structures such as tissue engineered scaffolds for biological applications...
August 1, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28748734/biochemical-alterations-induced-by-nickel-oxide-nanoparticles-in-female-wistar-albino-rats-after-acute-oral-exposure
#11
Naresh Dumala, Bhanuramya Mangalampalli, Kalyan Kamal Srinivasa Sarika, Paramjit Grover
CONTEXT: Nickel oxide (NiO) nanoparticles (NPs) with appropriate surface chemistry have been widely used for their potential new applications in biomedical industry. Increased usage of these NPs, enhances the chance of exposure of personnel involved in the work place. OBJECTIVE: This study was designed to assess the ability of NiO NPs to cause biochemical alterations post-acute oral exposure in female Wistar rats. MATERIALS AND METHODS: Rats were administered with 125, 250, and 500 mg/kg doses of NiO NPs for haematological, biochemical and histopathological studies...
July 27, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28726386/smart-biointerface-with-photoswitched-functions-between-bactericidal-activity-and-bacteria-releasing-ability
#12
Ting Wei, Wenjun Zhan, Qian Yu, Hong Chen
Smart biointerfaces with capability to regulate cell-surface interactions in response to external stimuli are of great interest for both fundamental research and practical applications. Smart surfaces with "ON/OFF" switchability for a single function such as cell attachment/detachment are well-known and useful, but the ability to switch between two different functions may be seen as the next level of "smart". In this work reported, a smart supramolecular surface capable of switching functions reversibly between bactericidal activity and bacteria-releasing ability in response to UV-visible light is developed...
August 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28722434/design-considerations-for-silica-particle-doped-nitric-oxide-releasing-polyurethane-glucose-biosensor-membranes
#13
Robert J Soto, Jonathon B Schofield, Shaylyn E Walter, Maggie J Malone-Povolny, Mark H Schoenfisch
Nitric oxide (NO)-releasing polymers have proven useful for improving the biocompatibility of in vivo glucose biosensors. Unfortunately, leaching of the NO donor from the polymer matrix remains a critical design flaw of NO-releasing membranes. Herein, a toolbox of NO-releasing silica nanoparticles (SNPs) was utilized to systematically evaluate SNP leaching from a diverse selection of biomedical-grade polyurethane sensor membranes. Glucose sensor analytical performance and NO-release kinetics from the sensor membranes were also evaluated as a function of particle and polyurethane (PU) chemistries...
January 27, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28691693/influence-of-physico-mechanical-properties-of-elastomeric-material-for-different-cell-growth
#14
Jyoti Wala, Debashis Maji, Soumen Das
The tunable mechanical and physical properties of Polydimethylsiloxane (PDMS) are commonly utilized for studying cellular dynamics. However, the inherent hydrophobic nature of PDMS limits its application as cell culture films. Various surface modification techniques render PDMS films hydrophilic which alters the surface chemistry, elasticity, roughness and cell attachment of anchorage dependent cell types to the films. The surface properties of thin film lead to alteration in bio-mechano-physical properties of cells and therefore could be used as mechanical signature for viability testing of different normal and cancerous cells...
July 10, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28687508/a-framework-for-the-targeted-selection-of-herbs-with-similar-efficacy-by-exploiting-drug-repositioning-technique-and-curated-biomedical-knowledge
#15
Sang-Jun Yea, Bu-Yeo Kim, Chul Kim, Mun Yong Yi
ETHNO PHARMACOLOGICAL RELEVANCE: Plants have been the most important natural resources for traditional medicine and for the modern pharmaceutical industry. They have been in demand in regards to finding alternative medicinal herbs with similar efficacy. Due to the very low probability of discovering useful compounds by random screening, researchers have advocated for using targeted selection approaches. Furthermore, because drug repositioning can speed up the process of drug development, an integrated technique that exploits chemical, genetic, and disease information has been recently developed...
July 5, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28686454/multiresponsive-nanogels-for-targeted-anticancer-drug-delivery
#16
Qiang Zhang, Juan Colazo, Darren Berg, Samuel M Mugo, Michael J Serpe
Nanogels with a biomolecular coating (biocoating) were shown to be capable of triggered delivery of anticancer drug Doxorubicin. The biocoating was formed utilizing binding between glycogen and the tetra-functional lectin Concanavalin A, which can be triggered to disassemble (and release) upon exposure to glucose and changes in solution pH. We also show the nanogel's thermoresponsivity can be used to accelerate Doxorubicin release. Moreover, we showed that transferrin immobilized on the nanogel surface could accelerate nanogel uptake by cancer cells...
August 7, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28676386/prodrugs-in-medicinal-chemistry-and-enzyme-prodrug-therapies
#17
Raoul Walther, Jarkko Rautio, Alexander N Zelikin
Prodrugs are cunning derivatives of therapeutic agents designed to improve the pharmacokinetics profile of the drug. Within a prodrug, pharmacological activity of the drug is masked and is recovered within the human body upon bioconversion of the prodrug, a process that is typically mediated by enzymes. This concept is highly successful and a significant fraction of marketed therapeutic formulations is based on prodrugs. An advanced subset of prodrugs can be engineered such as to achieve site-specific bioconversion of the prodrug - to comprise the highly advantageous "enzyme prodrug therapy", EPT...
July 1, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28665317/biological-fate-of-fe%C3%A2-o%C3%A2-core-shell-mesoporous-silica-nanoparticles-depending-on-particle-surface-chemistry
#18
Estelle Rascol, Morgane Daurat, Afitz Da Silva, Marie Maynadier, Christophe Dorandeu, Clarence Charnay, Marcel Garcia, Joséphine Lai-Kee-Him, Patrick Bron, Mélanie Auffan, Wei Liu, Bernard Angeletti, Jean-Marie Devoisselle, Yannick Guari, Magali Gary-Bobo, Joël Chopineau
The biological fate of nanoparticles (NPs) for biomedical applications is highly dependent of their size and charge, their aggregation state and their surface chemistry. The chemical composition of the NPs surface influences their stability in biological fluids, their interaction with proteins, and their attraction to the cell membranes. In this work, core-shell magnetic mesoporous silica nanoparticles (Fe₃O₄@MSN), that are considered as potential theranostic candidates, are coated with polyethylene glycol (PEG) or 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) lipid bilayer...
June 30, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28653066/on-the-binding-modes-of-metal-nhc-complexes-with-dna-secondary-structures-implications-for-therapy-and-imaging
#19
Özden Karaca, Samuel M Meier-Menches, Angela Casini, Fritz E Kühn
Organometallic compounds currently occupy an important place in the field of medicinal inorganic chemistry due to the unique chemical properties of metal coordination compounds. Particularly, metal compounds ligated by N-heterocyclic carbenes (NHC) have shown high potential for biomedical applications as antimicrobial and anticancer agents during the recent 15 years. Although further studies are necessary to validate the modes of action of this family of compounds, a number of biological targets have been identified, including DNA secondary structures...
June 27, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28645199/do-neurobiological-understandings-of-smoking-influence-quitting-self-efficacy-or-treatment-intentions
#20
Kylie Morphett, Adrian Carter, Wayne Hall, Jayne Lucke, Brad Partridge, Coral Gartner
Introduction: Addiction is increasingly defined as a "brain disease" caused by changes to neurochemistry. While nicotine addiction has historically been excluded in the brain disease model of addiction (BDMA), it is beginning to be labelled a chronic brain disease. We investigated whether Australian smokers endorse brain-based explanations of smoking, and whether these beliefs are associated with quitting self-efficacy or treatment intentions. Method: Cross-sectional study of Australian smokers (N=1,538) who completed a survey measuring their agreement with statements on the brain's role in smoking...
June 22, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
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