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Biomedical chemistry

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https://www.readbyqxmd.com/read/28225818/heat-induced-radiolabeling-and-click-chemistry-a-powerful-combination-for-generating-multifunctional-nanomaterials
#1
Hushan Yuan, Moses Q Wilks, Georges El Fakhri, Marc D Normandin, Charalambos Kaittanis, Lee Josephson
A key advantage of nanomaterials for biomedical applications is their ability to feature multiple small reporter groups (multimodality), or combinations of reporter groups and therapeutic agents (multifunctionality), while being targeted to cell surface receptors. Here a facile combination of techniques for the syntheses of multimodal, targeted nanoparticles (NPs) is presented, whereby heat-induced-radiolabeling (HIR) labels NPs with radiometals and so-called click chemistry is used to attach bioactive groups to the NP surface...
2017: PloS One
https://www.readbyqxmd.com/read/28215075/iron-oxide-surface-chemistry-the-effect-of-chemical-structure-on-binding-in-benzoic-acid-and-catechol-derivatives
#2
Katalin V Korpany, Dorothy D Majewski, Cindy T Chiu, Shoronia N Cross, Amy Szuchmacher Blum
Excellent performance of functionalized iron oxide nanoparticles in nanomaterial and biomedical applications often relies on achieving attachment of ligands to the iron oxide surface both in sufficient number and with proper orientation. Towards this end, we determine relationships between ligand chemical structure and surface binding on magnetic iron oxide nanoparticles for a series of related benzoic acid and catechol derivatives. Ligand exchange was used to introduce the model ligands, and the resulting nanoparticles were characterized by FTIR-ATR, transmission electron microscopy (TEM), and nanoparticle solubility behavior...
February 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28205401/computer-aided-drug-design-to-explore-cyclodextrin-therapeutics-and-biomedical-applications
#3
Azizeh Abdolmaleki, Fatemeh Ghasemi, Jahan B Ghasemi
Cyclodextrin (CD) is a subset of the macrocyclic structural class, which is an important class of small organic agents that are useful functional excipients. They have wide range application possibilities in different fields of sciences such as material preparation, medicine, analytical chemistry, and separation processes. They are used widely in pharmaceutical formulations and drug delivery for increasing the water solubility of low soluble drugs and drug candidates. Due to the ring structure, they behave differently than smaller molecules and may be capable of hitting new classes of targets...
February 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28183655/differential-cytotoxicity-and-internalization-of-graphene-family-nanomaterials-in-myocardial-cells
#4
Flavio F Contreras-Torres, Andrés Rodríguez-Galván, Carlos E Guerrero-Beltrán, Erick Martínez-Lorán, Eduardo Vázquez-Garza, Nancy Ornelas-Soto, Gerardo García-Rivas
Given the well-known physical properties of graphene oxide (GO), numerous applications for this novel nanomaterial have been recently envisioned to improve the performance of biomedical devices. However, the toxicological assessment of GO, which strongly depends on the used material and the studied cell line, is a fundamental task that needs to be performed prior to its use in biomedical applications. Therefore, the toxicological characterization of GO is still ongoing. This study contributes to this, aiming to synthesize and characterize GO particles and thus investigate their toxic effects in myocardial cells...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28181828/synthesis-of-sericin-based-conjugates-by-click-chemistry-enhancement-of-sunitinib-bioavailability-and-cell-membrane-permeation
#5
Luca Scrivano, Domenico Iacopetta, Maria Stefania Sinicropi, Carmela Saturnino, Pasquale Longo, Ortensia Ilaria Parisi, Francesco Puoci
Sericin is a natural protein that has been used in biomedical and pharmaceutical fields as raw material for polypeptide-based drug delivery systems (DDSs). In this paper, it has been employed as pharmaceutical biopolymer for the production of sunitinib-polypeptide conjugate. The synthesis has been carried out by simple click reaction in water, using the redox couple l-ascorbic acid/hydrogen peroxide as a free radical grafting initiator. The bioconjugate molecular weight (50 kDa < Mw < 75 kDa) was obtained by SDS-PAGE, while the spectroscopic characteristics have been studied in order to reveal the presence of grafted sunitinib...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28155937/controlled-aggregation-and-cell-uptake-of-thermoresponsive-polyoxazoline-grafted-superparamagnetic-iron-oxide-nanoparticles
#6
Steffen Kurzhals, Noga Gal, Ronald Zirbs, Erik Reimhult
Hydrophilic polymer-coated iron oxide nanoparticles are potential materials for a plethora of applications in the biotechnological field. Typical such polymers, e.g. dextran or poly(ethylene glycol), lack the ability to tailor the biological response to an environmental trigger, while common responsive polymers such as poly(N-isopropylacrylamide) or poly(acrylic acid) are not suitable for biomedical applications. We present the synthesis and characterization of superparamagnetic iron oxide nanoparticles with thermoresponsive polyoxazoline brushes grafted at unprecedented density using nitrodopamine anchor chemistry...
February 3, 2017: Nanoscale
https://www.readbyqxmd.com/read/28139927/continuous-in-flight-synthesis-for-on-demand-delivery-of-ligand-free-colloidal-gold-nanoparticles
#7
Paul Maguire, David Rutherford, Manuel Macias-Montero, Charles Mahony, Colin Kelsey, Mark Tweedie, Fátima Pérez-Martin, Harold McQuaid, Declan Diver, Davide Mariotti
We demonstrate an entirely new method of nanoparticle chemical synthesis based on liquid droplet irradiation with ultralow (<0.1 eV) energy electrons. While nanoparticle formation via high energy radiolysis or transmission electron microscopy-based electron bombardment is well-understood, we have developed a source of electrons with energies close to thermal which leads to a number of important and unique benefits. The charged species, including the growing nanoparticles, are held in an ultrathin surface reaction zone which enables extremely rapid precursor reduction...
January 31, 2017: Nano Letters
https://www.readbyqxmd.com/read/28126597/tuning-cell-adhesive-properties-via-layer-by-layer-assembly-of-chitosan-and-alginate
#8
Joana M Silva, José R García, Rui L Reis, Andrés J García, João F Mano
: Understanding the mechanisms controlling cell-multilayer film interactions is crucial to the successful engineering of these coatings for biotechnological and biomedical applications. Herein, we present a strategy to tune the cell adhesive properties of multilayers based on marine polysaccharides with and without cross-linking and/or coating with extracellular matrix proteins. Chemical cross-linking of multilayers improved mechanical properties of the coatings but also elicited changes in surface chemistry that alter the adhesion of human umbilical vein endothelial cells...
January 23, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28124034/low-fouling-and-functional-poly-carboxybetaine-coating-via-a-photo-crosslinking-process
#9
Hsiu-Wen Chien, Po-Hsiu Cheng, Shao-Yung Chen, Jiashing Yu, Wei-Bor Tsai
Antifouling modification technology is developed for many biomedical applications such as blood-contact devices and biosensors. In this work, a photo-reactive polymer containing zwitterionic carboxybetaine groups was prepared by copolymerization of two kinds of methacrylic acids with carboxybetaine and azidoaniline. The carboxybetaine moiety is for low fouling and the azidophenyl moiety is for photo-crosslinking. The synthesized copolymers were coated onto polymeric substrates, and then covalently immobilized on the substrates by exposure to UV radiation...
January 26, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28116390/recent-progress-in-cellulose-nanocrystals-sources-and-production
#10
REVIEW
Djalal Trache, M Hazwan Hussin, M K Mohamad Haafiz, Vijay Kumar Thakur
Cellulose nanocrystals, a class of fascinating bio-based nanoscale materials, have received a tremendous amount of interest both in industry and academia owing to its unique structural features and impressive physicochemical properties such as biocompatibility, biodegradability, renewability, low density, adaptable surface chemistry, optical transparency, and improved mechanical properties. This nanomaterial is a promising candidate for applications in fields such as biomedical, pharmaceuticals, electronics, barrier films, nanocomposites, membranes, supercapacitors, etc...
January 24, 2017: Nanoscale
https://www.readbyqxmd.com/read/28098453/surface-engineered-multifunctional-eu-gd2o3-nanoplates-for-targeted-and-ph-responsive-drug-delivery-and-imaging-applications
#11
Arindam Saha, Subas Chandra Mohanta, Kashmiri Deka, Pritam Deb, Parukuttyamma Sujatha Devi
In this paper, we report the synthesis of surface-engineered multifunctional Eu:Gd2O3 triangular nanoplates with small size and uniform shape via a high-temperature solvothermal technique. Surface engineering has been performed by a one-step polyacrylate coating, followed by controlled conjugation chemistry. This creates the desired number of surface functional groups that can be used to attach folic acid as a targeting ligand on the nanoparticle surface. To specifically deliver the drug molecules in the nucleus, the folate density on the nanoparticle surface has been kept low...
February 1, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28095847/the-biomedical-piglet-establishing-reference-intervals-for-haematology-and-clinical-chemistry-parameters-of-two-age-groups-with-and-without-iron-supplementation
#12
Domenico Ventrella, Francesco Dondi, Francesca Barone, Federica Serafini, Alberto Elmi, Massimo Giunti, Noemi Romagnoli, Monica Forni, Maria L Bacci
BACKGROUND: The similarities between swine and humans in physiological and genomic patterns, and the great correlation in size and anatomy, make pigs extremely useful in preclinical studies. New-born piglets can represent a model for congenital and genetic diseases in new-born children. It is known that piglets may have significant differences in clinicopathological results compared to adult pigs. Therefore, adult laboratory reference intervals cannot be applied to piglets. The aim of this study was to compare haematological and chemical variables in piglets of two ages and determinate age-related reference intervals for commercial hybrid young pigs...
January 17, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28094261/beyond-the-margins-real-time-detection-of-cancer-using-targeted-fluorophores
#13
REVIEW
Ray R Zhang, Alexandra B Schroeder, Joseph J Grudzinski, Eben L Rosenthal, Jason M Warram, Anatoly N Pinchuk, Kevin W Eliceiri, John S Kuo, Jamey P Weichert
Over the past two decades, synergistic innovations in imaging technology have resulted in a revolution in which a range of biomedical applications are now benefiting from fluorescence imaging. Specifically, advances in fluorophore chemistry and imaging hardware, and the identification of targetable biomarkers have now positioned intraoperative fluorescence as a highly specific real-time detection modality for surgeons in oncology. In particular, the deeper tissue penetration and limited autofluorescence of near-infrared (NIR) fluorescence imaging improves the translational potential of this modality over visible-light fluorescence imaging...
January 17, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28094081/emerging-human-fetuin-a-assays-for-biomedical-diagnostics
#14
REVIEW
Sandeep Kumar Vashist, E Marion Schneider, A G Venkatesh, John H T Luong
Human fetuin A (HFA) plays a prominent pathophysiological role in numerous diseases and pathophysiological conditions with considerable biomedical significance; one example is the formation of calciprotein particles in osteoporosis and impaired calcium metabolisms. With impressive advances in in vitro diagnostic assays during the last decade, ELISAs have become a workhorse in routine clinical diagnostics. Recent diagnostic formats involve high-sensitivity immunoassay procedures, surface plasmon resonance, rapid immunoassay chemistries, signal enhancement, and smartphone detection...
January 13, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28093367/effect-of-construction-of-tio2-nanotubes-on-platelet-behaviors-structure-property-relationships
#15
Qiaoling Huang, Yun Yang, Dajiang Zheng, Ran Song, Yanmei Zhang, Pinliang Jiang, Erwin A Vogler, Changjian Lin
: Blood compatibility of TiO2 nanotubes (TNTs) has been assessed in rabbit platelet-rich plasma (PRP), which combines activation of both blood plasma coagulation and platelets. We find that (i) amorphous TiO2 nanotubes (TNTs) with relatively larger outer diameters led to reduced platelet adhesion/activation, (ii) TNTs with relatively smaller outer diameters in a predominately rutile phase also inhibited platelet adhesion and activation, and (iii) a pervasive fibrin network formed on larger outer diameter TNTs in a predominately anatase phase...
January 13, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28092430/optimal-reactivity-and-improved-self-healing-capability-of-structurally-dynamic-polymers-grafted-on-janus-nanoparticles-governed-by-chain-stiffness-and-spatial-organization
#16
Guoxi Xu, Zihan Huang, Pengyu Chen, Tianqi Cui, Xinghua Zhang, Bing Miao, Li-Tang Yan
Structurally dynamic polymers are recognized as a key potential to revolutionize technologies ranging from design of self-healing materials to numerous biomedical applications. Despite intense research in this area, optimizing reactivity and thereby improving self-healing ability at the most fundamental level pose urgent issue for wider applications of such emerging materials. Here, the authors report the first mechanistic investigation of the fundamental principle for the dependence of reactivity and self-healing capabilities on the properties inherent to dynamic polymers by combining large-scale computer simulation, theoretical analysis, and experimental discussion...
January 16, 2017: Small
https://www.readbyqxmd.com/read/28078979/biotechnological-patents-applications-of-the-deuterium-oxide-in-human-health
#17
Alexsandro S Galdino, Reysla M da S Mariano, Wendell C Bila, Maria Jaciara F Trindade, Joel Alves Lamounier
BACKGROUND: Deuterium oxide is a molecule that has been used for decades in several studies related to human health. Currently, studies on D2O have mobilized a "Race for Patenting" worldwide. Several patents have been registered from biomedical and technological studies of D2O showing the potential of this stable isotope in industry and health care ecosystems. METHODS: Most of the patents relating to applications of the deuterium oxide in human health have been summarized in this review...
January 12, 2017: Recent Patents on Biotechnology
https://www.readbyqxmd.com/read/28078952/recent-advances-in-green-nanoparticulate-systems-for-drug-delivery-efficient-delivery-and-safety-concern
#18
Pik-Ling Lam, Wai-Yeung Wong, Zhaoxiang Bian, Chung-Hin Chui, Roberto Gambari
Nanotechnology manipulates therapeutic agents at the nanoscale for the development of nanomedicines. However, there are current concerns over nanomedicines, mainly related to the possible toxicity of nanomaterials used for health medications. Due to their small size, they can enter the human body more readily than larger sized particles. Green chemistry encompasses the green synthesis of drug-loaded nanoparticles by reducing the use of hazardous materials in the synthesis process, thus reducing the adverse health impacts of pharmaceutics...
January 12, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28075405/the-role-of-reactive-oxygen-species-ros-in-the-biological-activities-of-metallic-nanoparticles
#19
REVIEW
Ahmed Abdal Dayem, Mohammed Kawser Hossain, Soo Bin Lee, Kyeongseok Kim, Subbroto Kumar Saha, Gwang-Mo Yang, Hye Yeon Choi, Ssang-Goo Cho
Nanoparticles (NPs) possess unique physical and chemical properties that make them appropriate for various applications. The structural alteration of metallic NPs leads to different biological functions, specifically resulting in different potentials for the generation of reactive oxygen species (ROS). The amount of ROS produced by metallic NPs correlates with particle size, shape, surface area, and chemistry. ROS possess multiple functions in cellular biology, with ROS generation a key factor in metallic NP-induced toxicity, as well as modulation of cellular signaling involved in cell death, proliferation, and differentiation...
January 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28069502/synthesis-and-characterization-of-citrate-based-fluorescent-small-molecules-and-biodegradable-polymers
#20
Zhiwei Xie, Jimin P Kim, Qing Cai, Yi Zhang, Jinshan Guo, Ranjodh S Dhami, Li Li, Bin Kong, Yixue Su, Kevin A Schug, Jian Yang
: Novel citric acid based photoluminescent dyes and biodegradable polymers are synthesized via a facile "one-pot" reaction. A comprehensive understanding of the fluorescence mechanisms of the resulting citric acid-based fluorophores is reported. Two distinct types of fluorophores are identified: a thiozolopyridine family with high quantum yield, long lifetime, and exceptional photostability, and a dioxopyridine family with relatively lower quantum yield, multiple lifetimes, and solvent-dependent band shifting behavior...
January 6, 2017: Acta Biomaterialia
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