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https://www.readbyqxmd.com/read/28813021/enhanced-cell-growth-of-adipocyte-derived-mesenchymal-stem-cells-using-chemically-defined-serum-free-media
#1
Myung-Suk Lee, Christine Youn, Jeong Hyun Kim, Byoung Jun Park, Jongchan Ahn, Sungyoul Hong, Young-Deug Kim, Young Kee Shin, Sang Gyu Park
The multipotency and anti-inflammatory effects of mesenchymal stem cells (MSCs) make them attractive for cell therapy in regenerative medicine. A large number of MSCs is required for efficient therapy owing to the low homing efficiency of MSCs to target sites. Furthermore, owing to limitations in obtaining sufficient amounts of MSCs, in vitro expansion of MSCs that preserves their differentiation and proliferative potential is essential. The animal factor included in culture media also limits clinical application...
August 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28812315/metabolite-cycled-steam-and-semi-laser-localization-for-mr-spectroscopy-of-the-human-brain-at-9-4t
#2
Ioannis-Angelos Giapitzakis, Tingting Shao, Nikolai Avdievich, Ralf Mekle, Roland Kreis, Anke Henning
PURPOSE: Metabolite cycling (MC) is an MRS technique for the simultaneous acquisition of water and metabolite spectra that avoids chemical exchange saturation transfer effects and for which water may serve as a reference signal or contain additional information in functional or diffusion studies. Here, MC was developed for human investigations at ultrahigh field. METHODS: MC-STEAM and MC-semi-LASER are introduced at 9.4T with an optimized inversion pulse and elaborate coil setup...
August 15, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28811221/is-the-hype-around-the-reproductive-health-claims-of-maca-lepidium-meyenii-walp-justified
#3
REVIEW
Shruti Beharry, Michael Heinrich
ETHNOPHARMACOLOGICAL RELEVANCE: Maca - Lepidium meyenii Walp has been cultivated and used by Andean people for over 1,300 to 2000 years in Peru as food and medicine. Starting in the late 1990's it has developed into an important herbal medicine in China and is now cultivated there widely, too. AIM OF STUDY: This study aims to provide an insight into the emergence of maca on the global market as an alternative remedy to treat reproductive health related problems in both men and women and to critically assess these health claims...
August 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28809952/computational-and-experimental-analysis-of-short-peptide-motifs-for-enzyme-inhibition
#4
Jinglin Fu, Luca Larini, Anthony J Cooper, John W Whittaker, Azka Ahmed, Junhao Dong, Minyoung Lee, Ting Zhang
The metabolism of living systems involves many enzymes that play key roles as catalysts and are essential to biological function. Searching ligands with the ability to modulate enzyme activities is central to diagnosis and therapeutics. Peptides represent a promising class of potential enzyme modulators due to the large chemical diversity, and well-established methods for library synthesis. Peptides and their derivatives are found to play critical roles in modulating enzymes and mediating cellular uptakes, which are increasingly valuable in therapeutics...
2017: PloS One
https://www.readbyqxmd.com/read/28809931/the-cost-of-entry-an-analysis-of-pharmaceutical-registration-fees-in-low-middle-and-high-income-countries
#5
Steven G Morgan, Brandon Yau, Murray M Lumpkin
BACKGROUND: Advances in pharmaceuticals offer improved health outcomes for a wide range of illnesses, yet medicines are often inaccessible for many patients worldwide. One potential barrier to making medicines available to all is the cost of product registration, the fees for regulatory review and licensing for the sale of medicines beyond the cost of clinical trials, if needed. METHODS AND FINDINGS: We performed a cross-sectional analysis of pharmaceutical registration fees in low-, middle-, and high-income countries...
2017: PloS One
https://www.readbyqxmd.com/read/28808394/antiproliferative-activity-of-haematoxylum-brasiletto-h-karst
#6
J Bello-Martínez, M Jiménez-Estrada, J L Rosas-Acevedo, L P Avila-Caballero, M Vidal-Gutierrez, C Patiño-Morales, E Ortiz-Sánchez, R E Robles-Zepeda
BACKGROUND: Haematoxylum brasiletto is a tree that grows in Central America, commonly known as "Palo de Brasil," which is used in the traditional medicine for the treatment of cancer and gastric ulcers. OBJECTIVE: The aim of this study was to isolate the compounds responsible for antiproliferative activity of H. brasiletto. MATERIALS AND METHODS: A bioassay-guided fractionation of ethanol extract of H. brasiletto was performed using 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide cell proliferation assay to measure the antiproliferative activity on six human cancer cell lines (A549, LS180, HeLa, SiHa, MDA-MB-231, and NCI-H1299) and one human noncancer cell line (ARPE-19)...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28808391/resolving-identification-issues-of-saraca-asoca-from-its-adulterant-and-commercial-samples-using-phytochemical-markers
#7
Satisha Hegde, Harsha Vasudev Hegde, Sunil Satyappa Jalalpure, Malleswara Rao Peram, Sandeep Ramachandra Pai, Subarna Roy
Saraca asoca (Roxb.) De Wilde (Ashoka) is a highly valued endangered medicinal tree species from Western Ghats of India. Besides treating cardiac and circulatory problems, S. asoca provides immense relief in gynecological disorders. Higher price and demand, in contrast to the smaller population size of the plant, have motivated adulteration with other plants such as Polyalthia longifolia (Sonnerat) Thwaites. The fundamental concerns in quality control of S. asoca arise due to its part of medicinal value (Bark) and the chemical composition...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28808259/combination-of-chemical-fingerprint-and-bioactivity-evaluation-to-explore-the-antibacterial-components-of-salvia-miltiorrhizae
#8
Wei-Jun Kong, Shan-Shan Zhang, Yan-Ling Zhao, Ming-Quan Wu, Ping Chen, Xiao-Ru Wu, Xin-Ping Ma, Wei-Ying Guo, Mei-Hua Yang
The aim of this study was to explore the possible antibacterial components of Salvia miltiorrhizae on Pseudomonas aeruginosa using a combination of chemical fingerprint and bioactivity evaluation. The chemical fingerprints of 32 batches of S. miltiorrhizae samples from different sources were developed using high-performance liquid chromatography with diode array detection, and then were evaluated by similarity analysis and hierarchical clustering analysis. Anti-P. aeruginosa activity was determined by microcalorimetry...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28807230/global-identification-of-chemical-constituents-and-rat-metabolites-of-si-miao-wan-by-liquid-chromatography-electrospray-ionization-quadrupole-time-of-flight-mass-spectrometry
#9
Jin-Jin Lu, Xue-Wen Hu, Ping Li, Jun Chen
Si-Miao-Wan (SMW), a tradiational Chinese medicinal formula consisting of Atractylodis Rhizoma, Phellodendri Chinensis Cortex, Coicis Semen, and Achyranthis Bidentatae Radix, has been used for the treatment of gout and gouty arthritis for many years. In the present study, a liquid chromatography quadrupole-time-of-flight mass spectrometry (LC-Q-TOF/MS) method was established to identify the multiple constituents of SMW and its metabolites in rat biological samples after oral administration. A total of 48 compounds in SMW, including 21 alkaloids, 12 organic acids, 2 terpenes, 3 lactones, 2 phytosterols, and 8 other compounds, were tentatively characterized with the diagnostic-ion filtering strategy...
July 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28807166/neurobiology-of-chinese-herbal-medicine-on-major-depressive-disorder
#10
Gang Chen, Xiaoyan Guo
Major depressive disorder, or depression, becomes a serious public health problem globally. As current mainstream conventional antidepressants have limitations in unsatisfied response and remission rate, late onset of efficacy and side effects, increasing attention has been drawn to traditional Chinese medicine (TCM), in which mixture of herbs is commonly prescribed after the clinicians make pattern identification for diagnosis. Here, the principle of herbal formulation for TCM (Chinese herbal medicine, CHM) on depression as well as some clinical outcome research is briefly introduced...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28807163/effect-of-chinese-herbal-medicine-on-alzheimer-s-disease
#11
Melanie-Jayne R Howes, Rui Fang, Peter J Houghton
Alzheimer's disease (AD) is reaching epidemic proportions yet treatment strategies are limited and are restricted to providing symptomatic relief for the cognitive and behavioral and psychological symptoms of dementia (BPSD). Chinese herbal medicine (CHM) has been a valuable source of medicines for centuries and research has burgeoned in recent years to understand the scientific basis for their use. Some plants have been used in CHM for AD symptoms (e.g., Polygala tenuifolia), while others are CHMs for different conditions, but they show mechanistic effects relevant to AD (e...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28807159/herb-drug-interactions-of-commonly-used-chinese-medicinal-herbs
#12
Amrinder Singh, Kaicun Zhao
With more and more popular use of traditional herbal medicines, in particular Chinese herbal medicines, herb-drug interactions have become a more and more important safety issue in the clinical applications of the conventional drugs. Researches in this area are increasing very rapidly. Herb-drug interactions are complicated due to the fact that multiple chemical components are involved, and these compounds may possess diverse pharmacological activities. Interactions can be in both pharmacokinetics and pharmacodynamics...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28807157/antiinflammatory-and-hepatoprotective-medicinal-herbs-as-potential-substitutes-for-bear-bile
#13
Sandra Appiah, Mike Revitt, Huw Jones, Milan Vu, Monique Simmonds, Celia Bell
Practitioners of traditional Chinese medicine (TCM) commonly prescribe medicinal formulations relying on the purported synergism of a combination of plant species, sometimes incorporating animal parts and minerals. Bear bile, obtained from either wild or farmed bears, is a commonly used constituent of traditional medicine formulations. With several bear species now listed under Convention on International Trade in Endangered Species of Wild Fauna and Flora as threatened with extinction and with bear farming being actively campaigned against on ethical grounds, it is important to seek and promote alternatives to the use of bear bile as medicine...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28806082/the-discovery-of-novel-antimalarial-aminoxadiazoles-as-a-promising-nonendoperoxide-scaffold
#14
Elena Sandoval, María José Lafuente-Monasterio, María J Almela, Pablo Castañeda, María Belén Jiménez Díaz, María S Martínez-Martínez, Jaume Vidal, Íñigo Angulo-Barturen, Paul Bamborough, Jeremy Burrows, Nicholas Cammack, María J Chaparro, José M Coterón, Cristina de Cozar, Benigno Crespo, Beatriz Díaz, Gerard Drewes, Esther Fernández, Santiago Ferrer-Bazaga, María Teresa Fraile, Francisco J Gamo, Sonja Ghidelli-Disse, Rubén Gómez, John Haselden, Sophie Huss, María Luisa León, Jaime de Mercado, Simon J F Macdonald, José Ignacio Martín Hernando, Sara Prats, Margarita Puente, Anne Rodríguez, Juan C de la Rosa, Lourdes Rueda, Carolyn Selenski, Paul Willis, David M Wilson, Michael Witty, Félix Calderón
Since the appearance of resistance to the current front-line antimalarial treatments, ACTs (artemisinin combination therapies), the discovery of novel chemical entities to treat the disease is recognized as a major global health priority. From the GSK antimalarial set, we identified an aminoxadiazole with an antiparasitic profile comparable with artemisinin (1), with no cross-resistance in a resistant strains panel and a potential new mode of action. A medicinal chemistry program allowed delivery of compounds such as 19 with high solubility in aqueous media, an acceptable toxicological profile, and oral efficacy...
August 14, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28805726/chemical-identity-of-interaction-of-protein-with-reactive-metabolite-of-diosbulbin-b-in-vitro-and-in-vivo
#15
Kai Wang, Dongju Lin, Xiucai Guo, Wenlin Huang, Ying Peng, Jiang Zheng
Diosbulbin B (DIOB), a hepatotoxic furan-containing compound, is a primary ingredient in Dioscorea bulbifera L., a common herbal medicine. Metabolic activation is required for DIOB-induced liver injury. Protein covalent binding of an electrophilic reactive intermediate of DIOB is considered to be one of the key mechanisms of cytotoxicity. A bromine-based analytical technique was developed to characterize the chemical identity of interaction of protein with reactive intermediate of DIOB. Cysteine (Cys) and lysine (Lys) residues were found to react with the reactive intermediate to form three types of protein modification, including Cys adduction, Schiff's base, and Cys/Lys crosslink...
August 14, 2017: Toxins
https://www.readbyqxmd.com/read/28804933/chemical-functionalization-of-polysaccharides-towards-biocompatible-hydrogels-for-biomedical-applications
#16
Andreas Kirschning, Gerald Dräger, Nick Dibbert
Hydrogels have emerged as a highly interdisciplinary topic as they play a significant role for a vast number of applications. They have been studied extensively as materials for contact lenses, wound dressing and as filler material in soft-tissue augmentation, in which classical polymer backbones such as hydroxyethylmethacrylate (HEMA) are typically employed. More recently, polysaccharides have received attention, particularly in the fields of regenerative medicine and tissue engineering, as ideal candidate materials for artificial extracellular matrices (ECM)...
August 13, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28803117/phenolics-from-rubus-fairholmianus-induces-cytotoxicity-and-apoptosis-in-human-breast-adenocarcinoma-cells
#17
Blassan P George, Heidi Abrahamse, Nanjundaswamy M Hemmaragala
Herbal medicine is an important part of health care system in most of the countries. Rubus fairholmianus is an unexplored berry in folkloric medicine. In this study, we aimed to understand the importance of R. fairholmianus in pharmaceutical industry for the development of cost-effective cancer therapeutic drugs using in vivo and in vitro analysis. Chemical characterisation, antioxidant, antiproliferative and apoptosis inducing properties of R. fairholmianus root methanolic column subfraction (RFM) were investigated...
August 9, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28802227/anti-inflammatory-effects-of-shufengjiedu-capsule-for-upper-respiratory-infection-via-the-erk-pathway
#18
Yanmei Li, Nianwei Chang, Yanqi Han, Mengge Zhou, Jie Gao, Yuanyuan Hou, Min Jiang, Tiejun Zhang, Gang Bai
BACKGROUND: Shufengjiedu Capsule (SFJD) is a type of Chinese traditional medicine compound for the treatment of acute upper respiratory tract infection. The present work aims to decipher the mechanism of SFJD. METHODS: In this study, we used target prediction and RNA sequence (RNA-Seq) based on transcriptome analysis to clarify the inflammation-eliminating mechanism of SFJD. Firstly, Pseudomonas aeruginosa (PAK) was used to induce acute lung injury in KM mice. After being treated by SFJD, the differently expressed genes were analyzed by RNA-Seq...
August 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28802088/screening-bioactive-quality-control-markers-of-qishenyiqi-dripping-pills-based-on-the-relationship-between-the-ultra-high-performance-liquid-chromatography-fingerprint-and-vascular-protective-activity
#19
Limeng Zhuo, Jingjing Peng, Yunli Zhao, Dongxiang Li, Xiuman Xie, Ling Tong, Zhiguo Yu
Traditional Chinese medicine consists of complex phytochemical constituents. Selecting appropriately analytical markers of traditional Chinese medicine is a critical step in quality control. Currently, the combination of fingerprinting and efficacy evaluation is considered as a useful method for screening active ingredients in complex mixtures. This study was designed to develop an orthogonal partial least squares model for screening bioactive quality control markers of QishenYiqi dripping pills based on the fingerprint-efficacy relationship...
August 12, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28801633/evaluation-of-novel-factor-xa-inhibitors-from-oxya-chinensis-sinuosa-with-anti-platelet-aggregation-activity
#20
Wonhwa Lee, HeeSeung Lee, Mi-Ae Kim, Joonhyeok Choi, Kyung-Min Kim, Jae Sam Hwang, MinKyun Na, Jong-Sup Bae
The edible grasshopper Oxya chinensis sinuosa is consumed worldwide for its various medicinal effects. The purpose of this study was to investigate potential bioactive antithrombotic and antiplatelet compounds from O. chinensis sinuosa. Five N-acetyldopamine dimers (1-5) were isolated from O. chinensis sinuosa and compounds 1 and 2 were identified as new chemicals with chiral centers at H-2 and H-3 of the benzo-1,4-dioxane structure. Compounds 1-4 were found to have both FXa and platelet aggregation inhibitory activities...
August 11, 2017: Scientific Reports
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