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https://www.readbyqxmd.com/read/28533241/arr-cb-a-rifampin-resistance-determinant-found-active-or-cryptic-in-clostridium-bolteae
#1
Jean-Christophe Marvaud, Thierry Lambert
Clostridium bolteae, which belongs to the Clostridium clostridioforme complex is a member of the human gut microbiota. Recent analysis of seven genomes of C. bolteae revealed the presence of an arr-like gene. Among these strains only 90A7 was found to be resistant to rifampin in the absence of alteration in RpoB. Cloning of arr-cb from 90A7 in Escherichia coli combined with directed mutagenesis demonstrated that Arr-cb is functional but that a Q127→R variant present in 90A9 and 90B3 was inactive. qRT-PCR analysis indicated that arr-cb was silent in the four remaining strains due to a defective transcription...
May 22, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28529497/efficacy-and-safety-of-fingolimod-in-daily-practice-experience-of-an-academic-ms-french-center
#2
Thomas Roux, Elisabeth Maillart, Jean-Sébastien Vidal, Sophie Tezenas du Montcel, Catherine Lubetzki, Caroline Papeix
INTRODUCTION: Fingolimod (Fg), a sphingosine 1-phosphate receptor modulator, decreases the annual relapse rate (ARR) in relapsing-remitting multiple sclerosis (RRMS). The aim of this study was to assess the efficacy and safety of Fg in daily practice in patients with RRMS, previously treated with natalizumab (Nz) or not, and systematically followed during at least 1 year. METHODS: Data were collected from the patient files. Primary endpoint was the comparison between the ARR the year before Fg onset and after 1 and 2 years of Fg treatment...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28529209/quantitative-value-of-aldosterone-renin-ratio-for-detection-of-aldosterone-producing-adenoma-the-aldosterone-renin-ratio-for-primary-aldosteronism-aquarr-study
#3
Giuseppe Maiolino, Giacomo Rossitto, Valeria Bisogni, Maurizio Cesari, Teresa Maria Seccia, Mario Plebani, Gian Paolo Rossi
BACKGROUND: Current guidelines recommend use of the aldosterone-renin ratio (ARR) for the case detection of primary aldosteronism followed by confirmatory tests to exclude false-positive results from further diagnostic workup. We investigated the hypothesis that this could be unnecessary in patients with a high ARR value if the quantitative information carried by the ARR is taken into due consideration. METHODS AND RESULTS: We interrogated 2 large data sets of prospectively collected patients studied with the same predefined protocol, which included the captopril challenge test...
May 21, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28526027/description-of-inter-institutional-referrals-after-admission-for-labor-and-delivery-a-prospective-population-based-cohort-study-in-rural-maharashtra-india
#4
Archana B Patel, Amber Abhijeet Prakash, Camille Raynes-Greenow, Yamini V Pusdekar, Patricia L Hibberd
BACKGROUND: In 2008, the Indian government introduced financial assistance to encourage health facility deliveries. Facility births have increased, but maternal and neonatal morbidity and mortality have not decreased raising questions about the quality of care provided in facilities and access to a quality referral system. We evaluated the potential role of inter-institutional transfers of women admitted for labor and delivery on adverse maternal and neonatal outcomes in an ongoing prospective, population-based Maternal and Newborn Health Registry in Central India...
May 19, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28517950/gender-differences-in-service-utilization-among-operations-enduring-freedom-iraqi-freedom-and-new-dawn-veterans-affairs-patients-with-severe-mental-illness-and-substance-use-disorders
#5
Janelle M Painter, Emily Brignone, Amanda K Gilmore, Keren Lehavot, Jamison Fargo, Ying Suo, Tracy Simpson, Marjorie E Carter, Rebecca K Blais, Adi V Gundlapalli
Severe mental illness (SMI) and substance use disorders (SUD) are among the more chronic and costly mental health conditions treated in the Department of Veterans Affairs (VA). Service use patterns of returning veterans with SMI and SUD have received little attention. We examined gender differences in the utilization of VA services among a national sample of Operations Enduring Freedom, Iraqi Freedom, and New Dawn (OEF/OIF/OND) VA patients with SMI, SUD, and their comorbidity (SMI/SUD) in their first year of established VA care (N = 24,166)...
May 18, 2017: Psychological Services
https://www.readbyqxmd.com/read/28511732/outbreak-of-diarrhoea-among-participants-of-a-triathlon-and-a-duathlon-on-12-july-2015-in-utrecht-the-netherlands
#6
S Parkkali, R Joosten, E Fanoy, R Pijnacker, J VAN Beek, D Brandwagt, W VAN Pelt
On 12 July 2015, a triathlon competition with 900 participants took place in Utrecht, the Netherlands. An outbreak investigation was initiated after 56 participants reported health complaints. An online questionnaire was sent to 700 participants. Stool specimens from six participants and four water specimens were collected from the swimming location. A total of 239 participants completed the questionnaire (response rate: 34%), 73 (31%) of them met the case definition for acute gastrointestinal illness (AGI)...
May 17, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28508414/cervical-cerclage-placed-before-14%C3%A2-weeks-gestation-in-women-with-one-previous-midtrimester-loss-a-population-based-cohort-study
#7
Margaret E Harpham, Charles S Algert, Christine L Roberts, Jane B Ford, Antonia W Shand
BACKGROUND: Cervical cerclage is used in an attempt to reduce recurrence risk of preterm birth, but evidence for use is limited. AIMS: To compare pregnancy outcomes among women with a single previous midtrimester delivery when managed with or without a cervical cerclage. MATERIALS AND METHODS: Population-based cohort study of all women in New South Wales, Australia with a singleton pregnancy ending in birth/miscarriage ≥14 and <28 weeks, between 2003 and 2011...
May 16, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28506115/predictors-of-work-participation-for-m%C3%A4-ori-three-months-after-injury
#8
Emma H Wyeth, Brett Maclennan, Michelle Lambert, Gabrielle Davie, Rebbecca Lilley, Sarah Derrett
An important rehabilitation outcome for injured Māori is timely sustainable return to work. This paper identifies the factors influencing working after injury in an attempt to reduce the individual, social and economic costs. Māori participants in the Prospective Outcomes of Injury Study were interviewed, about pre-injury and injury-related factors. Among Māori participants, 521 were working for pay prior to injury; 64% were working three months post-injury. Factors identified, using modified Poisson regression, that predicted working include: financial security (aRR = 1...
May 16, 2017: Archives of Environmental & Occupational Health
https://www.readbyqxmd.com/read/28501795/patient-preferences-for-cardiovascular-preventive-medication-a-systematic-review
#9
REVIEW
Loai Albarqouni, Jenny Doust, Paul Glasziou
OBJECTIVE: To systematically review current evidence regarding the minimum acceptable risk reduction of a cardiovascular event that patients feel would justify daily intake of a preventive medication. METHODS: We used the Web of Science to track the forward and backward citations of a set of five key articles until 15 November 2016. Studies were eligible if they quantitatively assessed the minimum acceptable benefit-in absolute values-of a cardiovascular disease preventive medication among a sample of the general population and required participants to choose if they would consider taking the medication...
May 13, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28498189/impact-of-point-of-care-cd4-testing-on-retention-in-care-among-hiv-positive-pregnant-and-breastfeeding-women-in-the-context-of-option-b-in-zimbabwe-a-cluster-randomized-controlled-trial
#10
Jessica Joseph, Tendai Gotora, Alison S Erlwanger, Angela Mushavi, Simukai Zizhou, Nyasha Masuka, Caroline E Boeke, Alexio-Zambezi Mangwiro
INTRODUCTION: Scale-up of Option B+ in Zimbabwe has increased antiretroviral therapy (ART) coverage but patient loss-to-follow-up remains high; thus, effective strategies to improve retention in care are needed. Evidence for Elimination, a cluster randomized controlled trial, evaluated the impact of point-of-care (POC) CD4 testing with CD4 count-specific adherence counseling on rates of retention among 1150 HIV-positive pregnant women initiating ART in Zimbabwe. METHODS: Thirty-two primary care health facilities were randomized to offer either standard-of-care (SOC) or POC CD4 testing plus CD4-specific counseling to clients (POC Plus)...
June 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28497440/-treatment-of-relapsing-remitting-multiple-sclerosis-with-fingolimod-in-routine-clinical-practice
#11
C Alcala-Vicente, F C Perez-Miralles, F Gascon-Gimenez, I Bosca-Blasco, A Navarre-Gimeno, F Coret-Ferrer, B Casanova-Estruch
INTRODUCTION: Fingolimod is a selective immunosuppressant that targets the S1P receptor, and is indicated in the treatment of aggressive relapsing-remitting multiple sclerosis (RRMS) and following treatment failure with first-order drugs. AIM: To investigate the safety and effectiveness of fingolimod under the conditions of routine clinical practice. PATIENTS AND METHODS: We conducted an observational study with prospective follow-up of patients with RRMS who received fingolimod from January 2011 until February 2014...
May 16, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28495999/%C3%AE-arrestin-mediated-regulation-of-the-human-ether-a-go-go-related-gene-herg-potassium-channel
#12
Matthew G Sangoi, Shawn M Lamothe, Jun Guo, Tonghua Yang, Wentao Li, Ellen G Avery, John T Fisher, Shetuan Zhang
The rapidly activating delayed rectifier K(+) channel (IKr) is encoded by the human ether-a-go-go-related gene (hERG), which is important for the repolarization of the cardiac action potential. Mutations in hERG or drugs can impair the function or decrease the expression level of hERG channels, leading to long QT syndrome (LQTS). Thus, it is important to understand hERG channel trafficking and its regulation. For this purpose, G protein-coupled receptors (GPCRs), which regulate a vast array of cellular processes, represent a useful route...
May 11, 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/28495266/maternal-pre-pregnancy-infection-with-hepatitis-b-virus-and-the-risk-of-preterm-birth-a-population-based-cohort-study
#13
Jue Liu, Shikun Zhang, Min Liu, Qiaomei Wang, Haiping Shen, Yiping Zhang
BACKGROUND: Preterm birth is the leading cause of child death in children younger than 5 years. Large cohort studies in developed countries have shown that maternal hepatitis B virus infection is associated with preterm birth, but there is little reliable evidence from China and other developing countries, where hepatitis B virus prevalence is intermediate or high. Hence, we designed this study to investigate the association between pre-pregnancy hepatitis B virus infection and risk of preterm and early preterm birth...
June 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28493291/prevalence-of-primary-aldosteronism-among-patients-with-type-2-diabetes
#14
M Tancredi, G Johansson, B Eliasson, R Eggertsen, U Lindblad, S Dahlqvist, H Imberg, M Lind
CONTEXT: Diabetes and hypertension coexist in 40-60% of individuals with type 2 diabetes. The coexistence of this two conditions is associated with increased risk of retinopathy, nephropathy and cardiovascular disease. OBJECTIVE: To investigate the prevalence of primary aldosteronism (PA) in a general cohort of persons with type 2 diabetes. DESIGN: Cross-sectional study involving 6 diabetes outpatient clinics in Sweden. PATIENTS: Were enrolled individuals with type 2 diabetes between February 2008 and December 2013...
May 10, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28472944/risk-of-incident-active-tuberculosis-disease-in-patients-treated-with-non-steroidal-anti-inflammatory-drugs-a-population-based-study
#15
Chun-Wei Wu, Jiunn-Yih Wu, Meng-Tse Gabriel Lee, Chih-Cheng Lai, I-Lin Wu, Yi-Wen Tsai, Shy-Shin Chang, Chien-Chang Lee
BACKGROUND: Mycobacterium tuberculosis (TB) is one of the world's most devastating public health threats. Our goal is to evaluate whether the use of non-steroidal anti-inflammatory drugs (NSAIDs) affect the risk of new incident active TB disease. METHODS: We conducted a nested case-control analysis by using a 1 million longitudinally followed cohort, from Taiwan's national health insurance research database. Effects of NSAIDs on active TB were estimated by conditional logistic regression and adjusted using a TB-specific disease risk score (DRS)...
May 4, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28467152/the-interaction-between-glucose-and-cytokinin-signaling-in-controlling-arabidopsis-thaliana-seedling-root-growth-and-development
#16
Sunita Kushwah, Ashverya Laxmi
Cytokinin (CK) and glucose (GLC) control several common responses in plants. There is an extensive overlap between CK and GLC signal transduction pathways in Arabidopsis. Physiologically, both GLC and CK could regulate root length in light. CK interacts with GLC via HXK1 dependent pathway for root length control. Wild-type (WT) roots cannot elongate in the GLC free medium while CK-receptor mutant ARABIDOPSIS HISTIDINE KINASE4 (ahk4) and type B ARR triple mutant ARABIDOPSIS RESPONSE REGULATOR1, 10,11 (arr1, 10,11) roots could elongate even in the absence of GLC as compared with the WT...
May 3, 2017: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/28461293/breastfeeding-maternal-asthma-and-wheezing-in-the-first-year-of-life-a%C3%A2-longitudinal-birth-cohort-study
#17
Meghan B Azad, Lorena Vehling, Zihang Lu, David Dai, Padmaja Subbarao, Allan B Becker, Piushkumar J Mandhane, Stuart E Turvey, Diana L Lefebvre, Malcolm R Sears
The impact of breastfeeding on respiratory health is uncertain, particularly when the mother has asthma. We examined the association of breastfeeding and wheezing in the first year of life.We studied 2773 infants from the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort. Caregivers reported on infant feeding and wheezing episodes at 3, 6 and 12 months. Breastfeeding was classified as exclusive, partial (supplemented with formula or complementary foods) or none.Overall, 21% of mothers had asthma, 46% breastfed for at least 12 months and 21% of infants experienced wheezing...
May 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28460079/postpartum-complications-in-new-mothers-with-juvenile-idiopathic-arthritis-a-population-based-cohort-study
#18
Debbie Ehrmann Feldman, Évelyne Vinet, Marie-Pierre Sylvestre, Beth Hazel, Ciarán Duffy, Anick Bérard, Garbis Meshefedjian, Sasha Bernatsky
Objective.: The aim was to evaluate the prevalence of postpartum complications, including depression, in new mothers who had juvenile idiopathic arthritis (JIA) and to assess whether these differ from mothers who never had JIA. Methods.: Our cohort study used data from physician billing and hospitalizations covering Quebec, Canada. We identified females with JIA with a first-time birth between 1 January 1983 and 31 December 2010 and assembled a control cohort of first-time mothers without JIA from the same administrative data, matching 4:1 for date of first birth, maternal age and area of residence...
April 27, 2017: Rheumatology
https://www.readbyqxmd.com/read/28459838/ebola-management-centre-proximity-associated-with-reduced-delays-of-healthcare-of-ebola-virus-disease-evd-patients-tonkolili-sierra-leone-2014-15
#19
Georgios Theocharopoulos, Kostas Danis, Jane Greig, Alexandra Hoffmann, Henriette De Valk, Augustine Jimissa, Sumaila Tejan, Mohammed Sankoh, Karline Kleijer, Will Turner, Jay Achar, Jennifer Duncombe, Kamalini Lokuge, Ivan Gayton, Rob Broeder, Ronald Kremer, Grazia Caleo
Between August-December 2014, Ebola Virus Disease (EVD) patients from Tonkolili District were referred for care to two Médecins Sans Frontières (MSF) Ebola Management Centres (EMCs) outside the district (distant EMCs). In December 2014, MSF opened an EMC in Tonkolili District (district EMC). We examined the effect of opening a district-based EMC on time to admission and number of suspect cases dead on arrival (DOA), and identified factors associated with fatality in EVD patients, residents in Tonkolili District...
2017: PloS One
https://www.readbyqxmd.com/read/28456863/performance-and-kinetics-of-anammox-granular-sludge-with-ph-shock-in-a-sequencing-batch-reactor
#20
Jin Li, Weiqiang Zhu, Huiyu Dong, Dan Wang
As an efficient and cost-effective nitrogen removal process, anaerobic ammonium oxidation (ANAMMOX) could be well operated at suitable pH condition. However, pH shock occurred in different kinds of wastewater and affected ANANNOX process greatly. The present research aimed at studying the performance and kinetics of ANAMMOX granular sludge with pH shock. When influent pH was below 7.5, effluent [Formula: see text]-N and [Formula: see text]-N increased with decreasing pH. At Ph 6.0, effluent [Formula: see text]-N approached 100 mg/L, and the ratios of [Formula: see text] approached 2...
April 29, 2017: Biodegradation
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