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https://www.readbyqxmd.com/read/28715158/loss-to-follow-up-among-children-and-adolescents-growing-up-with-hiv-infection-age-really-matters
#1
Katharina Kranzer, John Bradley, Joseph Musaazi, Mary Nyathi, Hilary Gunguwo, Wedu Ndebele, Mark Dixon, Mbongeni Ndhlovu, Andrea Rehman, Palwasha Khan, Florian Vogt, Tsitsi Apollo, Rashida Abbas Ferrand
INTRODUCTION: Globally, increasing numbers of HIV-infected children are reaching adolescence due to antiretroviral therapy (ART). We investigated rates of loss-to-follow-up (LTFU) from HIV care services among children as they transition from childhood through adolescence. METHODS: Individuals aged 5-19 years initiated on ART in a public-sector HIV clinic in Bulawayo, Zimbabwe, between 2005 and 2009 were included in a retrospective cohort study. Participants were categorized into narrow age-bands namely: 5-9 (children), 10-14 (young adolescents) and 15-19 (older adolescents)...
July 17, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28713355/respiratory-pathways-reconstructed-by-multi-omics-analysis-in-melioribacter-roseus-residing-in-a-deep-thermal-aquifer-of-the-west-siberian-megabasin
#2
Sergey Gavrilov, Olga Podosokorskaya, Dmitry Alexeev, Alexander Merkel, Maria Khomyakova, Maria Muntyan, Ilya Altukhov, Ivan Butenko, Elizaveta Bonch-Osmolovskaya, Vadim Govorun, Ilya Kublanov
Melioribacter roseus, a representative of recently proposed Ignavibacteriae phylum, is a metabolically versatile thermophilic bacterium, inhabiting subsurface biosphere of the West-Siberian megabasin and capable of growing on various substrates and electron acceptors. Genomic analysis followed by inhibitor studies and membrane potential measurements of aerobically grown M. roseus cells revealed the activity of aerobic respiratory electron transfer chain comprised of respiratory complexes I and IV, and an alternative complex III...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28708809/gender-differences-in-outcomes-of-antiretroviral-treatment-among-hiv-infected-patients-in-china-a-retrospective-cohort-study-2010-2015
#3
Meiling Chen, Zhihui Dou, Liming Wang, Yasong Wu, Decai Zhao, Xiumin Gan, Hu Ran, Ye Ma, Zhang Fujie
BACKGROUD: Women now account for about half of all people living with HIV worldwide, but researchers lack clear information and large population-based study about gender differences in treatment outcomes. METHODS: A nationwide retrospective observational cohort study with data from the China National Free Antiretroviral Treatment Program was carried out. Antiretroviral-naïve patients older than 18 years initiating standard antiretroviral therapy between January 1, 2010 and December 31, 2011 were included and followed up to Dec 31, 2015...
July 8, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28704548/socio-economic-predictors-of-stillbirths-in-nepal-2001-2011
#4
Pramesh Raj Ghimire, Kingsley Emwinyore Agho, Andre Renzaho, Aliki Christou, Monjura Khatun Nisha, Michael Dibley, Camille Raynes-Greenow
INTRODUCTION: Stillbirth has a long-lasting impact on parents and families. This study examined socio-economic predictors associated with stillbirth in Nepal for the year 2001, 2006 and 2011. METHODS: The Nepalese Demographic and Health Survey (NDHS) data for the period (2001-2011) were pooled to estimate socio-economic predictors associated with stillbirths in Nepal using binomial logistic regression while taking clustering and sampling weights into account. RESULTS: A total of 18,386 pregnancies of at least 28 weeks gestation were identified...
2017: PloS One
https://www.readbyqxmd.com/read/28700818/fetal-mca-doppler-to-time-intrauterine-transfusions-in-red-cell-alloimmunisation-a-randomised-trial
#5
Jodie M Dodd, Chad Andersen, Jan E Dickinson, Jennie Louise, Andrea Deussen, Rosalie M Grivell, Liliana Voto, Mark D Kilby, Rory Windrim, Greg Ryan
OBJECTIVES: Red cell alloimmunisation affects up to 0.6% of all live births, and can be successfully treated with intrauterine fetal blood transfusion. Fetal middle cerebral artery (MCA) Doppler peak systolic velocity (PSV) is a non-invasive test, to identify fetal anaemia and requiring intrauterine transfusion (IUT). Traditionally, timing of subsequent IUTs has involved estimating a fall in fetal haematocrit of 1% per day, or a fall in fetal haemoglobin of 0.3 g/dL per day. The aim of this pragmatic multi-centre randomised trial was to evaluate whether Doppler MCA-PSV in the fetus that has undergone one IUT for anaemia secondary to red cell alloimmunisation was non-inferior to timing IUT by timing based on predicting the fall in fetal haematocrit or fetal haemoglobin, without compromising infant haemoglobin at birth...
July 12, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28698073/does-a-body-mass-index-greater-than-25kg-m-2-increase-maternal-and-neonatal-morbidity-a-french-historical-cohort-study
#6
Philippe Deruelle, Elie Servan-Schreiber, Olivier Riviere, Charles Garabedian, Françoise Vendittelli
OBJECTIVES: To evaluate, in a French multicenter cohort, the risk of C-section based on a high pre-pregnancy body mass index (BMI). Secondary objectives were to assess the risk of elective C-section, severe post-partum hemorrhage (> 1 L), severe perineal tears (3(rd) and 4(th) degree) and neonatal complications according to pre-pregnancy BMI. STUDY DESIGN: This historical cohort study analyzed records from the French AUDIPOG perinatal database. Inclusion criteria were deliveries ≥ 22 weeks (or with a birth weight ≥ 500g)...
July 8, 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/28692173/perinatal-and-maternal-morbidity-and-mortality-among-term-singletons-following-midcavity-operative-vaginal-delivery-versus-caesarean-delivery
#7
Giulia M Muraca, Amanda Skoll, Sarka Lisonkova, Yasser Sabr, Rollin Brant, Geoffrey W Cundiff, K S Joseph
OBJECTIVE: To quantify severe perinatal and maternal morbidity/mortality associated with midcavity operative vaginal delivery compared with caesarean delivery. DESIGN: Population-based, retrospective cohort study. SETTING: British Columbia, Canada. POPULATION: Term, singleton deliveries (2004-2014) by attempted midcavity operative vaginal delivery or caesarean delivery in the second stage of labour, stratified by indication for operative delivery (n=10,901 deliveries; 5,057 indicated for dystocia, 5,844 for fetal distress)...
July 10, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28687066/genomic-characterization-of-a-large-plasmid-containing-a-bla-ndm-1-gene-carried-on-salmonella-enterica-serovar-indiana-c629-isolate-from-china
#8
Wei Wang, Zulqarnain Baloch, Zixin Peng, Yujie Hu, Jin Xu, Séamus Fanning, Fengqin Li
BACKGROUND: The bla NDM-1 gene in Salmonella species is mostly reported in clinical cases, but is rarely isolated from red and white meat in China. METHODS: A Salmonella Indiana (S. Indiana) isolate was cultured from a chicken carcass procured from a slaughterhouse in China. Antimicrobial susceptibility was tested against a panel of agents. Whole-genome sequencing of the isolate was carried out and data was analyzed. RESULTS: A large plasmid, denoted as plasmid pC629 (210,106 bp), containing a composite cassette, consisting of IS26-bla NDM-1-ble MBL -△trpF-tat-cutA-ISCR1-sul1-qacE△1-aadA2-dfrA12-intI1-IS26 was identified...
July 7, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28686197/vulnerability-reduction-needed-to-maintain-current-burdens-of-heat-related-mortality-in-a-changing-climate-magnitude-and-determinants
#9
Christofer Åström, Daniel Oudin Åström, Camilla Andersson, Kristie L Ebi, Bertil Forsberg
The health burden from heatwaves is expected to increase with rising global mean temperatures and more extreme heat events over the coming decades. Health-related effects from extreme heat are more common in elderly populations. The population of Europe is rapidly aging, which will increase the health effects of future temperatures. In this study, we estimate the magnitude of adaptation needed to lower vulnerability to heat in order to prevent an increase in heat-related deaths in the 2050s; this is the Adaptive Risk Reduction (ARR) needed...
July 7, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28682319/neonatal-abstinence-syndrome-and-early-childhood-morbidity-and-mortality-in-washington-state-a-retrospective-cohort-study
#10
C E Witt, K E Rudd, P Bhatraju, F P Rivara, S E Hawes, N S Weiss
OBJECTIVE: The objective of the study was to evaluate the association between neonatal abstinence syndrome (NAS) and long-term childhood morbidity and infant mortality. STUDY DESIGN: We conducted a cohort study of infants born in Washington State during 1990 to 2008 who were diagnosed with NAS (n=1900) or were unexposed (n=12,283, frequency matched by birth year). 5-year hospital readmissions and infant mortality were ascertained. RESULTS: Children with history of NAS had increased risk of readmission during the first 5 years of life relative to unexposed children; this remained statistically significant after adjustment for maternal age, maternal education, gestational age and intrapartum smoking status (readmission rates: NAS=21...
July 6, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28679367/relationship-between-azathioprine-metabolites-and-therapeutic-efficacy-in-chinese-patients-with-neuromyelitis-optica-spectrum-disorders
#11
Xindi Li, Shenghui Mei, Xiaoqing Gong, Heng Zhou, Li Yang, Anna Zhou, Yonghong Liu, Xingang Li, Zhigang Zhao, Xinghu Zhang
BACKGROUND: Neuromyelitis optica spectrum disorders (NMOSD) are demyelinating autoimmune diseases in the central nervous system (CNS) that are characterized by a high relapse rate and the presence of anti-aquaporin 4 antibodies (AQP4-IgG) in the serum. Azathioprine (AZA) is a first-line immunomodulatory drug that is widely used for the treatment of patients with NMOSD. However, the efficacy and safety of AZA vary in different individuals. METHOD: Thirty-two patients with NMOSD who regularly took AZA were enrolled in the study at Beijing Tiantan Hospital, Capital Medical University...
July 5, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28678814/long-term-health-status-and-trajectories-of-seriously-injured-patients-a-population-based-longitudinal-study
#12
Belinda J Gabbe, Pam M Simpson, Peter A Cameron, Jennie Ponsford, Ronan A Lyons, Alex Collie, Mark Fitzgerald, Rodney Judson, Warwick J Teague, Sandra Braaf, Andrew Nunn, Shanthi Ameratunga, James E Harrison
BACKGROUND: Improved understanding of the quality of survival of patients is crucial in evaluating trauma care, understanding recovery patterns and timeframes, and informing healthcare, social, and disability service provision. We aimed to describe the longer-term health status of seriously injured patients, identify predictors of outcome, and establish recovery trajectories by population characteristics. METHODS AND FINDINGS: A population-based, prospective cohort study using the Victorian State Trauma Registry (VSTR) was undertaken...
July 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28674133/effect-of-adherence-to-antihypertensive-medication-on-stroke-incidence-in-patients-with-hypertension-a-population-based-retrospective-cohort-study
#13
Hyo Jung Lee, Sung-In Jang, Eun-Cheol Park
OBJECTIVE: High blood pressure is a modifiable risk factor for stroke, but non-adherence to antihypertensive medication is a growing concern for healthcare providers in controlling blood pressure. This study aimed to investigate the effect of adherence to antihypertensive medication on stroke incidence. DESIGN: Retrospective cohort study. SETTING: We analysed National Health Insurance claim data and check-up data from 2009 to 2013. PARTICIPANTS: 38520patients with hypertension were defined as those diagnosed with hypertension and prescribed antihypertensive medication...
July 2, 2017: BMJ Open
https://www.readbyqxmd.com/read/28673986/cytokinin-induces-genome-wide-binding-of-the-type-b-response-regulator-arr10-to-regulate-growth-and-development-in-arabidopsis
#14
Yan O Zubo, Ivory Clabaugh Blakley, Maria V Yamburenko, Jennifer M Worthen, Ian H Street, José M Franco-Zorrilla, Wenjing Zhang, Kristine Hill, Tracy Raines, Roberto Solano, Joseph J Kieber, Ann E Loraine, G Eric Schaller
The plant hormone cytokinin affects a diverse array of growth and development processes and responses to the environment. How a signaling molecule mediates such a diverse array of outputs and how these response pathways are integrated with other inputs remain fundamental questions in plant biology. To this end, we characterized the transcriptional network initiated by the type-B ARABIDOPSIS RESPONSE REGULATORs (ARRs) that mediate the cytokinin primary response, making use of chromatin immunoprecipitation sequencing (ChIP-seq), protein-binding microarrays, and transcriptomic approaches...
July 3, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28672763/a-step-by-step-approach-in-differential-diagnosing-of-adrenal-incidentaloma-epinephroma-with-comments-on-the-new-clinical-practice-guidelines-of-the-european-society-of-endocrinology
#15
Frederick-Anthony Farrugia, Evangelos Misiakos, Georgios Martikos, Panagiotis Tzanetis, Anestis Charalampopoulos, Nicolaos Zavras, Dimitrios Sotiropoulos, Nikolaos Koliakos
OBJECTIVES: To present a step by step approach for the diagnosis of adrenal incidentaloma (AI). METHOD: An extensive review of the literature was conducted, searching the Pub-Med and Google Scholar using the Mesh terms; Adrenal; Incidentaloma; Adrenal tumours; Radiology; Diagnosis. We also did a cross-referencing search of the literature. Comments on the new European guidelines are presented. RESULTS: The majority of the tumours are non-functioning benign adenomas...
June 23, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28672292/association-between-pregnancy-and-perinatal-outcomes-among-women-with-epilepsy
#16
Neda Razaz, Torbjörn Tomson, Anna-Karin Wikström, Sven Cnattingius
Importance: To date, few attempts have been made to examine associations between exposure to maternal epilepsy with or without antiepileptic drug (AED) therapy and pregnancy and perinatal outcomes. Objectives: To investigate associations between epilepsy in pregnancy and risks of pregnancy and perinatal outcomes as well as whether use of AEDs influenced risks. Design, Setting, and Participants: A population-based cohort study was conducted on all singleton births at 22 or more completed gestational weeks in Sweden from 1997 through 2011; of these, 1 424 279 were included in the sample...
July 3, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28670841/the-sensitivity-of-38-heart-rate-variability-measures-to-the-addition-of-artifact-in-human-and-artificial-24-hr-cardiac-recordings
#17
Nicolas J C Stapelberg, David L Neumann, David H K Shum, Harry McConnell, Ian Hamilton-Craig
BACKGROUND: Artifact is common in cardiac RR interval data derived from 24-hr recordings and has a significant impact on heart rate variability (HRV) measures. However, the relative impact of progressively added artifact on a large group of commonly used HRV measures has not been assessed. This study compared the relative sensitivity of 38 commonly used HRV measures to artifact to determine which measures show the most change with increasing increments of artifact. A secondary aim was to ascertain whether short-term and long-term HRV measures, as groups, share similarities in their sensitivity to artifact...
July 2, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28670437/use-of-clinical-chromosomal-microarray-in-chinese-patients-with-autism-spectrum-disorder-implications-of-a-copy-number-variation-involving-dpp10
#18
Annisa Shui Lam Mak, Annie Ting Gee Chiu, Gordon Ka Chun Leung, Christopher Chun Yu Mak, Yoyo Wing Yiu Chu, Gary Tsz Kin Mok, Wing Fai Tang, Kelvin Yuen Kwong Chan, Mary Hoi Yin Tang, Elizabeth Tak-Kwong Lau Yim, Kin Wai So, Victoria Qinchen Tao, Cheuk Wing Fung, Virginia Chun Nei Wong, Mohammed Uddin, So Lun Lee, Christian R Marshall, Stephen W Scherer, Anita Sik Yau Kan, Brian Hon Yin Chung
BACKGROUND: Array comparative genomic hybridization (aCGH) is recommended as a first-tier genetic test for children with autism spectrum disorder (ASD). However, interpretation of results can often be challenging partly due to the fact that copy number variants (CNVs) in non-European ASD patients are not well studied. To address this literature gap, we report the CNV findings in a cohort of Chinese children with ASD. METHODS: DNA samples were obtained from 258 Chinese ASD patients recruited from a child assessment center between January 2011 and August 2014...
2017: Molecular Autism
https://www.readbyqxmd.com/read/28669321/factors-associated-with-receiving-an-hiv-test-among-patients-admitted-through-the-emergency-unit-at-a-kenyan-referral-hospital
#19
Rebecca Bridge, Janet Lin
Despite decreasing incidence, HIV is the leading cause of morbidity and mortality in Kenya. In Kisumu, HIV prevalence is ∼19% and incidence is second highest in the country. There is a need to identify HIV-positive persons and link them to care. Universal testing in healthcare facilities is a strategy supported by the Kenyan government to facilitate identification of new HIV cases. The objective was to identify patterns of HIV testing in a hospital in Kisumu, Kenya, a setting where universal testing is recommended...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28662947/rehospitalization-through-childhood-and-adolescence-association-with-neonatal-morbidities-in-infants-of-very-low-birth-weight
#20
Jacob Kuint, Liat Lerner-Geva, Gabriel Chodick, Valentina Boyko, Varda Shalev, Brian Reichman
OBJECTIVE: To evaluate the impact of major neonatal morbidities on the risks for rehospitalization in children and adolescents born of very low birth weight. STUDY DESIGN: An observational study was performed on data of the Israel Neonatal Network linked together with the Maccabi Healthcare Services medical records. After discharge from the neonatal intensive care unit, 6385 infants of very low birth weight born from 1995 to 2012 were registered with Maccabi Healthcare Services and formed the study cohort...
June 26, 2017: Journal of Pediatrics
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