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https://www.readbyqxmd.com/read/29212952/dysregulated-aldosterone-secretion-in-persons-of-african-descent-with-endothelin-1-gene-variants
#1
Jia W Tan, Tina Gupta, Worapaka Manosroi, Tham M Yao, Paul N Hopkins, Jonathan S Williams, Gail K Adler, Jose R Romero, Gordon H Williams
Compared with persons of European descent (ED), persons of African descent (AD) have lower aldosterone (ALDO) levels, with the assumption being that the increased cardiovascular disease (CVD) risk associated with AD is not related to ALDO. However, the appropriateness of the ALDO levels for the volume status in AD is unclear. We hypothesized that, even though ALDO levels are lower in AD, they are inappropriately increased, and therefore, ALDO could mediate the increased CVD in AD. To test this hypothesis, we analyzed data from HyperPATH - 1,788 individuals from the total cohort and 765 restricted to ED-to-AD in a 2:1 match and genotyped for the endothelin-1 gene (EDN1)...
December 7, 2017: JCI Insight
https://www.readbyqxmd.com/read/29212491/case-report-schwannoma-arising-from-the-unilateral-adrenal-area-with-bilateral-hyperaldosteronism
#2
Naru Babaya, Yukako Makutani, Shinsuke Noso, Yoshihisa Hiromine, Hiroyuki Ito, Yasunori Taketomo, Kazuki Ueda, Hokuto Ushijima, Yoshifumi Komoike, Yuto Yamazaki, Hironobu Sasano, Yumiko Kawabata, Hiroshi Ikegami
BACKGROUND: We report a rare case of a juxta-adrenal schwannoma that could not be discriminated from an adrenal tumor before surgical resection and was complicated by bilateral hyperaldosteronism. To the best of our knowledge, this is first case in which both a juxta-adrenal schwannoma and hyperaldosteronism co-existed. CASE PRESENTATION: A 69-year-old male treated for hypertension was found to have a left supra-renal mass (5.8 × 5.2 cm) by abdominal computed tomography...
December 6, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29212450/the-impact-of-virus-infections-on-pneumonia-mortality-is-complex-in-adults-a-prospective-multicentre-observational-study
#3
Naoko Katsurada, Motoi Suzuki, Masahiro Aoshima, Makito Yaegashi, Tomoko Ishifuji, Norichika Asoh, Naohisa Hamashige, Masahiko Abe, Koya Ariyoshi, Konosuke Morimoto
BACKGROUND: Various viruses are known to be associated with pneumonia. However, the impact of viral infections on adult pneumonia mortality remains unclear. This study aimed to clarify the effect of virus infection on pneumonia mortality among adults stratified by virus type and patient comorbidities. METHODS: This multicentre prospective study enrolled pneumonia patients aged ≥15 years from September 2011 to August 2014. Sputum samples were tested by in-house multiplex polymerase chain reaction assays to identify 13 respiratory viruses...
December 6, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29211885/outcome-of-surgical-intervention-for-aortic-root-abscess-a-meta-analysis
#4
Guan-Jhou Chen, Wei-Cheng Lo, Hsien-Wei Tseng, Sung-Ching Pan, Yih-Sharng Chen, Shan-Chwen Chang
OBJECTIVES: Aortic root abscess (ARA) is a catastrophic complication of aortic root endocarditis, involving both native and prosthetic valves, which often warrants surgical intervention. Currently, aortic valve replacement (AVR) and aortic root replacement (ARR) are the most widely employed techniques. However, evidence that directly compares these methods is scarce. In this meta-analysis, we aimed to describe the surgical outcome of ARA when using different surgical methods. METHODS: In this meta-analysis, we performed literature searches in the EMBASE and PubMed databases and reviewed articles describing postoperative results of ARA that were published before 30 June 2016...
December 2, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29209873/99mtc-rituximab-as-a-tracer-for-sentinel-lymph-node-biopsy-in-breast-cancer-patients-a-single-center-analysis
#5
Jiwei Wang, Tie Fan, Yingjian He, Xue Chen, Zhaoqing Fan, Yuntao Xie, Tianfeng Wang, Jinfeng Li, Tao Ouyang
PURPOSE: This study aimed to determine the long-term prognosis of breast cancer patients with 99mTc-rituximab for sentinel lymph node biopsy (SLNB). METHODS: A total of 2947 patients with negative sentinel lymph nodes (SLNs) omitting axillary lymph node dissection (ALND), treated between June 2005 and December 2013, were retrospectively analyzed. SLNB was performed prior to adjuvant therapy. RESULTS: After a median follow-up of 62 months, 22 cases of axillary recurrence (AR) were observed...
December 6, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29204707/ocular-surface-and-tear-film-status-among-contact-lens-wearers-and-non-wearers-who-use-vdt-at-work-comparing-three-different-lens-types
#6
Ana Tauste, Elena Ronda, Valborg Baste, Magne Bråtveit, Bente E Moen, María-Del-Mar Seguí Crespo
PURPOSE: To analyze differences in the ocular surface appearance and tear film status of contact lens wearers and non-wearers in a group of visual display terminals (VDT) workers and additionally to assess differences between lens materials. METHODS: Cross-sectional study of 236 office workers, of whom 92 were contact lens wearers. Workers provided information on their contact lenses (conventional hydrogel, silicone hydrogel or rigid gas permeable lenses) and exposure to VDT at work...
December 4, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/29202664/suicide-attempts-and-completions-among-mothers-whose-children-were-taken-into-care-by-child-protection-services-a-cohort-study-using-linkable-administrative-data
#7
Elizabeth Wall-Wieler, Leslie L Roos, Marni Brownell, Nathan Nickel, Dan Chateau, Deepa Singal
OBJECTIVE: The objective of this study is to examine suicide attempts and completions among mothers who had a child taken into care by child protection services (CPS). These mothers were compared with their biological sisters who did not have a child taken into care and with mothers who received services from CPS but did not have a child taken into care. METHODS: A retrospective cohort of mothers whose first child was born in Manitoba, Canada, between April 1, 1992, and March 31, 2015, is used...
January 1, 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/29189194/the-dietary-diversity-and-stunting-prevalence-in-minority-children-under-3-years-old-a-cross-sectional-study-in-forty-two-counties-of-western-china
#8
Anqi Wang, Robert W Scherpbier, Xiaona Huang, Sufang Guo, Yuning Yang, Jonathan Josephs-Spaulding, Chuyang Ma, Hong Zhou, Yan Wang
As a key indicator of childhood malnutrition, few studies have focused on stunting in relation to various socio-economic factors in which disadvantaged groups face in China. We conducted a community-based cross-sectional study incorporating forty-two rural counties in seven western provinces of China in 2011. In total, 5196 children aged 6-23 months were included. We used Poisson regression to examine risk factors for inadequate minimum dietary diversity (MDD) and stunting status, respectively. Overall, the proportion of children not meeting MDD was 44·5 %...
November 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29188615/-prenatal-diagnosis-of-two-fetuses-with-chromosome-1p36-deletion-syndrome
#9
Xiuqing Ji, Huanran Hu, Yan Wang, Dong Liang, Chunyu Luo, Lulu Meng, Jing Zhou, Li Cao, Dingyuan Ma, Ping Hu, Zhengfeng Xu
OBJECTIVE: To analyze two fetuses with multiple malformations revealed by ultrasonography using single nucleotide polymorphism array (SNP array), and to explore the strategy for the prenatal diagnosis of 1p36 deletion syndrome. METHODS: Amniocentesis was performed on the two pregnant women. Amnion fluid cells were cultured, and karyotypes of the fetuses were determined through G-banding analysis. Whole genome SNP array was used to detect genomic anomalies of the two fetuses...
December 10, 2017: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/29188425/increased-benefit-of-betrixaban-among-patients-with-a-history-of-venous-thromboembolism-a-post-hoc-analysis-of-the-apex-trial
#10
Megan K Yee, Tarek Nafee, Yazan Daaboul, Serge Korjian, Fahad AlKhalfan, Mathieu Kerneis, Cara Wiest, Samuel Z Goldhaber, Adrian F Hernandez, Russell D Hull, Alexander T Cohen, Robert A Harrington, C Michael Gibson
Hospitalized acute medically ill patients with a history of venous thromboembolism (VTE) are at increased risk for recurrent VTE. We characterized the efficacy and safety of betrixaban for prevention of recurrent VTE in these high risk patients. The APEX trial randomized 7513 acutely ill hospitalized medical patients at risk for developing VTE to receive either betrixaban for 35-42 days or enoxaparin for 10 ± 4 days to prevent VTE. This exploratory post-hoc analysis assessed the efficacy and safety of betrixaban versus enoxaparin among subjects with and without prior VTE...
November 29, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29186581/type-b-arrs-control-carpel-regeneration-through-mediating-agamous-expression-in-arabidopsis
#11
Xiao Fei Rong, Ya Lin Sang, Liang Wang, Wen Jing Meng, Chun Hao Zou, Yu Xiu Dong, Xiao Min Bie, Zhi Juan Cheng, Xian Sheng Zhang
Plants are known for their capacity to regenerate organs, such as shoot, root and floral organs. Recently, a number of studies contributed to understanding mechanisms of shoots and roots regeneration. However, the mechanisms underlying floral organ regeneration are largely unknown. In this study, we established a carpel regeneration system in which two types of carpels were induced by exogenous cytokinin. For typeI, all the floral organs in the regenerated inflorescence were transformed into carpels. For type II, carpels were generated directly from callus...
November 24, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29185005/larger-range-of-motion-and-increased-return-to-activity-but-higher-revision-rates-following-unicompartmental-versus-total-knee-arthroplasty-in-patients-under-65-a-systematic-review
#12
REVIEW
Laura J Kleeblad, Jelle P van der List, Hendrik A Zuiderbaan, Andrew D Pearle
PURPOSE: Due to the lack of comparative studies, a systematic review was conducted to determine revision rates of unicompartmental and total knee arthroplasty (UKA and TKA), and compare functional outcomes, range of motion and activity scores in patients less than 65 years of age. METHODS: A literature search was performed using PubMed, Embase, and Cochrane systems since 2000. 27 UKA and 33 TKA studies were identified and included. Annual revision rate (ARR), functional outcomes, and return to activity were assessed for both types of arthroplasty using independent t tests...
November 28, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29182993/lymphocyte-count-in-peripheral-blood-is-not-associated-with-the-level-of-clinical-response-to-treatment-with-fingolimod
#13
Yara Dadalti Fragoso, Tim Spelman, Cavit Boz, Raed Alroughani, Alessandra Lugaresi, Steve Vucic, Helmut Butzkueven, Murat Terzi, Eva Havrdova, Dana Horakova, Franco Granella, Javier Olascoaga, José Luis Sánchez-Menoyo, Eugenio Pucci, Michael Barnett, Joseph Bruno B Brooks, Jodi Haartsen
BACKGROUND: Fingolimod is an efficient and safe drug for treating relapsing-remitting multiple sclerosis (RRMS). In vivo, fingolimod is phosphorylated and binds to "sphingosine-1-phosphate"(S1P) receptors that are expressed in a wide range of cells, including lymphocytes. Under the effect of fingolimod, lymphocytes are retained in lymphoid tissues through the regulation of S1P1 receptors. The aim of the present study was to assess whether the degree of lymphopenia was correlated to the positive treatment response of RRMS patients with fingolimod...
November 22, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29176849/association-between-non-barrier-modern-contraceptive-use-and-condomless-sex-among-hiv-positive-female-sex-workers-in-mombasa-kenya-a-prospective-cohort-analysis
#14
Diya Surie, Krista Yuhas, Kate Wilson, Linnet N Masese, Juma Shafi, John Kinuthia, Walter Jaoko, R Scott McClelland
BACKGROUND: As access to antiretroviral therapy in sub-Saharan Africa continues to expand, more women with HIV can expect to survive through their reproductive years. Modern contraceptives can help women choose the timing and spacing of childbearing. However, concerns remain that women with HIV who use non-barrier forms of modern contraception may engage in more condomless sex because of their decreased risk of unintended pregnancy. We examined whether non-barrier modern contraceptive use by HIV-positive female sex workers was associated with increased frequency of recent condomless sex, measured by detection of prostate-specific antigen (PSA) in vaginal secretions...
2017: PloS One
https://www.readbyqxmd.com/read/29173286/an-airway-rapid-response-system-implementation-and-utilization-in-a-large-academic-trauma-center
#15
Joshua H Atkins, Christopher H Rassekh, Ara A Chalian, Jing Zhao
BACKGROUND: Rapid response teams mobilize resources to patients experiencing acute deterioration. Failed airway management results in death or anoxic brain injury. A codified, systems-based approach to bring personnel and equipment to the bedside for multidisciplinary airway assessment and rescue was reflected in the initial implementation of an airway rapid response (ARR) team. METHODS: A retrospective review of records of 117 ARR events in a 40-month period (August 2011-November 2014) was undertaken at the Hospital of the University of Pennsylvania, a 789-bed, academic, urban, tertiary care, Level 1 trauma center...
December 2017: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/29171862/deployment-related-military-sexual-trauma-predicts-heavy-drinking-and-alcohol-problems-among-male-reserve-and-national-guard-soldiers
#16
Jennifer Fillo, Sarah Cercone Heavey, D Lynn Homish, Gregory G Homish
BACKGROUND: Military sexual trauma (MST) is associated with a range of deleterious mental and physical health consequences; however, far less attention has been paid to the associations between MST and negative health behaviors, such as substance abuse. This study examined 2 focal research questions: (i) What is the prevalence of experiencing MST during deployment among male Reserve and National Guard soldiers? and (ii) to what extent is the degree of MST exposure during deployment associated with frequent heavy drinking and alcohol problems postdeployment? METHODS: Data from male soldiers who had been deployed (N = 248) were drawn from the baseline wave of Operation: SAFETY (Soldiers And Families Excelling Through the Years) an ongoing study examining health among U...
November 24, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29164179/schroth-physiotherapeutic-scoliosis-specific-exercises-for-adolescent-idiopathic-scoliosis-how-many-patients-require-treatment-to-prevent-one-deterioration-results-from-a-randomized-controlled-trial-sosort-2017-award-winner
#17
Sanja Schreiber, Eric C Parent, Doug L Hill, Douglas M Hedden, Marc J Moreau, Sarah C Southon
Background: Recent randomized controlled trials (RCTs) support using physiotherapeutic scoliosis-specific exercises (PSSE) for adolescents with idiopathic scoliosis (AIS). All RCTs reported statistically significant results favouring PSSE but none reported on clinical significance. The number needed to treat (NNT) helps determine if RCT results are clinically meaningful. The NNT is the number of patients that need to be treated to prevent one bad outcome in a given period. A low NNT suggests that a therapy has positive outcomes in most patients offered the therapy...
2017: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/29159801/real-life-clinical-use-of-natalizumab-and-fingolimod-in-austria
#18
M Guger, C Enzinger, F Leutmezer, J Kraus, S Kalcher, E Kvas, T Berger
OBJECTIVES: To compare the efficacy of natalizumab or fingolimod in a nationwide observational cohort using prospectively collected data. MATERIALS AND METHODS: We included all patients starting treatment with natalizumab or fingolimod documented in the Austrian MS Treatment Registry (AMSTR) from 2011 and staying on therapy for at least 24 months. We used propensity scores for several matching methods and as a covariate in multivariate models to correct for the bias of this non-randomized registry study...
November 20, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29157859/adolescents-and-young-adults-reports-of-barriers-to-confidential-health-care-and-receipt-of-contraceptive-services
#19
Liza Fuentes, Meghan Ingerick, Rachel Jones, Laura Lindberg
PURPOSE: The purpose of this study was to describe adolescents' and young adults' concerns about confidential reproductive health care and experience with time alone with a provider, and examine the association of these confidentiality issues with receipt of contraceptive services. METHODS: Data from the 2013 to 2015 National Survey of Family Growth were analyzed using Poisson regression to describe 15- to 25-year-olds' confidential reproductive health-care concerns and time alone with a provider at last health-care visit according to sociodemographic characteristics...
November 17, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29153725/differentiating-among-attempted-completed-and-multiple-nonfatal-strangulation-in-women-experiencing-intimate-partner-violence
#20
Jill Theresa Messing, Michelle Patch, Janet Sullivan Wilson, Gabor D Kelen, Jacquelyn Campbell
PURPOSE: Because identification of intimate partner violence (IPV) in health care settings is low and strangulation increases lethality risk among women experiencing IPV, we examined the prevalence and correlates of nonfatal strangulation among 1,008 women survivors of IPV. METHODS: Trained researchers conducted semistructured interviews with women survivors of IPV referred by police. Multinomial logistic regression examined differential correlates of attempted, completed, and multiple strangulation...
November 16, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
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