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https://www.readbyqxmd.com/read/29666985/induction-of-disease-remission-with-one-cycle-of-alemtuzumab-in-relapsing-remitting-ms
#1
Alexandra S Kocsik, David E Klein, Maryana Liedke, Ulrike W Kaunzner, Nancy M Nealon, Susan A Gauthier, Timothy Vartanian, Jai S Perumal
OBJECTIVE: To investigate a single-course treatment with alemtuzumab in patients with relapsing-remitting multiple sclerosis. METHODS: We performed a retrospective chart review of all patients diagnosed with RRMS who were treated with alemtuzumab at our MS center and who had at least 12 month follow-up since the first dose. Data on radiological and clinical relapse were collected for the 2 years prior to patients' first dose of alemtuzumab and were tracked until the time of analysis...
April 17, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29661642/an-abstinence-and-safer-sex-intervention-for-adolescents-attending-the-public-sexually-transmitted-infection-clinic-in-singapore
#2
Junice Yi Siu Ng, Roy Kum Wah Chan, Martin Tze-Wei Chio, Raymond Boon Tar Lim, David Koh, Mee Lian Wong
PURPOSE: The objective of this study was to evaluate the efficacy of a behavioral intervention in increasing secondary abstinence and safer sex among heterosexually active adolescents aged 16-19 years. METHODS: This was a randomized controlled trial conducted at the only national sexually transmitted infection clinic in Singapore. The intervention focused on information giving, motivation, and skills building to abstain or practice safer sex. The outcome measures were self-reported secondary abstinence, consistent condom use, and keeping to one partner in the past 6 months over a 12-month period...
April 13, 2018: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29659728/racial-disparities-in-invasive-methicillin-resistant-staphylococcus-aureus-infections-2005-2014
#3
Nicole Gualandi, Yi Mu, Wendy M Bamberg, Ghinwa Dumyati, Lee H Harrison, Lindsey Lesher, Joelle Nadle, Sue Petit, Susan M Ray, William Schaffner, John Townes, Mariana McDonald, Isaac See
Background: Despite substantial attention to the individual topics, little is known about the relationship between racial disparities and antimicrobial-resistant and/or healthcare-associated infection trends, such as infections due to methicillin-resistant Staphylococcus aureus (MRSA). Methods: We analyzed CDC's Emerging Infections Program 2005-2014 surveillance data (9 U.S. states) to determine whether reductions in invasive MRSA incidence (isolated from normally sterile body sites) affected racial disparities in rates...
April 5, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29659021/absence-of-a-moderating-effect-of-parent-health-literacy-on-early-head-start-enrollment-and-dental-use
#4
Jacqueline M Burgette, John S Preisser, Morris Weinberger, Rebecca S King, Jessica Y Lee, R Gary Rozier
OBJECTIVES: To examine the moderating effect of parents' health literacy (HL) on the effectiveness of North Carolina Early Head Start (EHS) in improving children's dental use. METHODS: Parents of 479 children enrolled in EHS and 699 Medicaid-matched parent-child dyads were interviewed at baseline when children were approximately 10 months old and 24 months later. We used in-person computer-assisted, structured interviews to collect information on sociodemographic characteristics, dental use, and administer the Short Assessment of Health Literacy - Spanish and English (SAHL-S&E)...
April 16, 2018: Journal of Public Health Dentistry
https://www.readbyqxmd.com/read/29658177/patterns-of-statin-use-and-long-term-adherence-and-persistence-among-older-adults-with-diabetes
#5
Richard Ofori-Asenso, Jenni Llomäki, Mark Tacey, Ella Zomer, Andrea J Curtis, J Simon Bell, Sophia Zoungas, Danny Liew
BACKGROUND: Statins reduce the risk of cardiovascular disease in patients with diabetes. We examined the prevalence of statin use and assessed the long-term adherence and persistence among people aged ≥65 years with diabetes. METHODS: Pharmaceutical Benefits Scheme data covering a 10% random sample of the Australian population were analysed. Among older adults with diabetes, the yearly prevalence of statin use was compared via Poisson regression modelling using 2006 as the reference year...
April 15, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29655877/endocrine-and-haemodynamic-changes-in-resistant-hypertension-and-blood-pressure-responses-to-spironolactone-or-amiloride-the-pathway-2-mechanisms-substudies
#6
Bryan Williams, Thomas M MacDonald, Steve V Morant, David J Webb, Peter Sever, Gordon T McInnes, Ian Ford, J Kennedy Cruickshank, Mark J Caulfield, Sandosh Padmanabhan, Isla S Mackenzie, Jackie Salsbury, Morris J Brown
BACKGROUND: In the PATHWAY-2 study of resistant hypertension, spironolactone reduced blood pressure substantially more than conventional antihypertensive drugs. We did three substudies to assess the mechanisms underlying this superiority and the pathogenesis of resistant hypertension. METHODS: PATHWAY-2 was a randomised, double-blind crossover trial done at 14 UK primary and secondary care sites in 314 patients with resistant hypertension. Patients were given 12 weeks of once daily treatment with each of placebo, spironolactone 25-50 mg, bisoprolol 5-10 mg, and doxazosin 4-8 mg and the change in home systolic blood pressure was assessed as the primary outcome...
April 11, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29652999/-application-of-single-nucleotide-polymorphism-microarray-and-fluorescence-in-situ-hybridization-analysis-for-the-prenatal-diagnosis-of-a-case-with-pallister-killian-syndrome
#7
Wenling Zhang, Zhichao Guo, Weiwei Wang, Yonghui Sun, Chenxi Zhang, Xiaofei Wang, Liwen Zhang, Chengbin Wang
OBJECTIVE: To explore the clinical and genetic characteristics of a case with Pallister-Killian syndrome (PKS). METHODS: Chromosomal karyotype of umbilical cord blood sample derived from a 36-year-old pregnant woman was analyzed by G-banding analysis. After birth, the child was further analyzed with single nucleotide polymorphism microarray (SNP array) and fluorescence in situ hybridization (FISH) using 12pter/12qter probes. RESULTS: G-banding analysis showed that the fetus has a karyotype of 46,XY [77]/47,XY,+mar [23]...
April 10, 2018: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/29648900/no-evidence-of-disease-activity-in-patients-receiving-fingolimod-at-private-or-academic-centers-in-clinical-practice-a-retrospective-analysis-of-the-multiple-sclerosis-clinical-and-magnetic-resonance-imaging-outcomes-in-the-usa-ms-mrius-study
#8
Robert Zivadinov, Nasreen Khan, Jonathan R Korn, Ellen Lathi, Jason Silversteen, Jonathan Calkwood, Scott Kolodny, Diego Silva, Jennie Medin, Bianca Weinstock-Guttman
OBJECTIVE: The impact of multiple sclerosis (MS) center type on outcomes has not been investigated. This study aimed to evaluate baseline characteristics and clinical and magnetic resonance imaging (MRI) outcomes in patients with MS receiving fingolimod over 16 months' follow-up at private or academic centers in the USA. METHODS: Clinical and MRI data collected in clinical practice from patients initiating fingolimod were stratified by center type and retrospectively analyzed...
April 12, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29643479/use-of-statins-and-the-risk-of-dementia-and-mild-cognitive-impairment-a-systematic-review-and-meta-analysis
#9
Che-Sheng Chu, Ping-Tao Tseng, Brendon Stubbs, Tien-Yu Chen, Chia-Hung Tang, Dian-Jeng Li, Wei-Cheng Yang, Yen-Wen Chen, Ching-Kuan Wu, Nicola Veronese, Andre F Carvalho, Brisa S Fernandes, Nathan Herrmann, Pao-Yen Lin
We conducted a systematic review and meta-analysis to investigate whether the use of statins could be associated with the risk of all-caused dementia, Alzheimer's disease (AD), vascular dementia (VaD), and mild cognitive impairment (MCI). Major electronic databases were searched until December 27th , 2017 for studies investigating use of statins and incident cognitive decline in adults. Random-effects meta-analyses calculating relative risks (RRs) were conducted to synthesize effect sizes of individual studies...
April 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29624866/factors-associated-with-recovery-delay-in-a-sample-of-patients-diagnosed-by-mers-cov-rrt-pcr-a-saudi-arabian-multicenter-retrospective-study
#10
Anwar E Ahmed, Hamdan Al-Jahdali, Mody Alaqeel, Salma S Siddiq, Hanan A Alsaab, Ezzeldin A Sakr, Hamed A Alyahya, Munzir M Alandonisi, Alaa T Subedar, Yosra Z Ali, Hazza Al Otaibi, Nouf M Aloudah, Salim Baharoon, Sameera Al Johani, Mohammed G Alghamdi
AIM: Research evidence exists that poor prognosis is common in Middle East Respiratory Syndrome Coronavirus (MERS-CoV) patients. This study estimates recovery delay intervals and identifies associated factors in a sample of Saudi Arabian patients admitted for suspected MERS-CoV and diagnosed by rRT-PCR assay. METHOD: A multicenter retrospective study was conducted on 829 patients admitted between September 2012 and June 2016 and diagnosed by rRT-PCR procedures to have MERS-CoV and non-MERS-CoV infection in which 396 achieved recovery...
April 6, 2018: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29620955/the-anatomy-features-and-variations-of-the-point-where-right-gastroepiploic-vein-flows-into-superior-mesenteric-vein-portal-vein-anatomical-study-of-catheterization-of-portal-vein-infusion-chemotherapy
#11
Xingxing Liu, Jian Yang, Xia-Xi Li, Nan Xiang, Ning Zeng, Ying-Fang Fan, Chi-Hua Fang
INTRODUCTION: To study the anatomical features and classification of the angle between the right gastroepiploic vein (RGEV) and superior mesenteric vein/portal vein (SMV/PV) and to guide the catheterization of intraportal infusion chemotherapy through RGEV and reduce surgical complications. PATIENTS AND METHODS: A retrospective three-dimensional (3D) computed tomography study was undertaken on 200 consecutive subjects with or without hepatic malignant tumors with a dedicated workstation 3D-MIA (the improved MI-3DVS workstation) developed by ourselves to determine the prevalence of surgically significant angle between RGEV and SMV/PV anatomic variations and its classification...
April 5, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29617437/patient-nominated-supporters-as-facilitators-for-engagement-in-hiv-care-in-a-referral-hospital-in-peru-a-retrospective-cohort-study
#12
Mateo Prochazka, Larissa Otero, Kelika A Konda, Elsa González-Lagos, Juan Echevarría, Eduardo Gotuzzo
Patient-nominated supporters can potentially improve the continuum of HIV care. We retrospectively determined factors associated with having a patient-nominated supporter among people living with HIV (PLWH), and its association with retention in care and viral suppression. We analysed registries of adults evaluated by social workers (n = 1345) at a referral hospital in Peru between 2011-2014. Nondisclosure of HIV status was associated with lacking supporters (aPR: 5.41, 95% CI: 3.83-7.64). Retention in care was 76...
2018: PloS One
https://www.readbyqxmd.com/read/29616500/effect-of-obesity-on-postacute-outcomes-of-skilled-nursing-facility-residents-with-hip-fracture
#13
Cyrus M Kosar, Kali S Thomas, Pedro L Gozalo, Jessica A Ogarek, Vincent Mor
OBJECTIVES: To examine the effect of obesity (body mass index (BMI)≥30.0 kg/m2 ) on outcomes of older adults admitted to skilled nursing facilities (SNFs) for hip fracture postacute care (PAC). DESIGN: Retrospective cohort study. SETTING: U.S. Medicare- and Medicaid-certified SNFs from 2008 to 2015. PARTICIPANTS: Medicare fee-for-service beneficiaries discharged to a SNF after hospitalization for hip fracture (N=586,683; n=82,768 (14...
April 3, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29602171/appendicectomy-during-pregnancy-and-the-risk-of-preterm-birth-a-population-data-linkage-study
#14
Ibinabo Ibiebele, Margaret Schnitzler, Tanya Nippita, Jane B Ford
BACKGROUND: Suspected appendicitis is a common non-obstetric indication for emergency abdominal surgery during pregnancy. AIMS: Assess the risk of preterm birth and other maternal and neonatal adverse birth outcomes following appendicectomy during pregnancy. MATERIALS AND METHODS: Population-based data linkage study of women with singleton births in New South Wales, Australia, 2002-2014. Pregnancies with appendicitis and appendicectomy were compared to pregnancies without appendicitis...
March 30, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29596818/clinical-outcomes-of-root-reimplantation-and-bentall-procedure-propensity-score-matching-analysis
#15
Heemoon Lee, Yang Hyun Cho, Kiick Sung, Wook Sung Kim, Kay-Hyun Park, Dong Seop Jeong, Pyo Won Park, Young Tak Lee
BACKGROUND: This study aimed to evaluate the clinical outcomes of aortic root replacement(ARR) surgery:Root reimplantation as valve-sparing root replacement(VSR) and the Bentall procedure. METHODS: We retrospectively reviewed 216 patients who underwent ARR between 1995 and 2013 at Samsung Medical Center. Patients were divided into two groups, depending on the procedure they underwent: Bentall(n=134) and VSR(n=82). The mean follow-up duration was 100.9±56.4 months...
March 26, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29590216/perception-of-the-importance-of-chemistry-research-papers-and-comparison-to-citation-rates
#16
Rachel Borchardt, Cullen Moran, Stuart Cantrill, Chemjobber, See Arr Oh, Matthew R Hartings
Chemistry researchers are frequently evaluated on the perceived significance of their work with the citation count as the most commonly-used metric for gauging this property. Recent studies have called for a broader evaluation of significance that includes more nuanced bibliometrics as well as altmetrics to more completely evaluate scientific research. To better understand the relationship between metrics and peer judgements of significance in chemistry, we have conducted a survey of chemists to investigate their perceptions of previously published research...
2018: PloS One
https://www.readbyqxmd.com/read/29589136/syndemic-conditions-hiv-transmission-risk-behavior-and-transactional-sex-among-transgender-women
#17
Jeffrey T Parsons, Nadav Antebi-Gruszka, Brett M Millar, Demetria Cain, Sitaji Gurung
This study examined the effect of four syndemic conditions-namely, polydrug use, depression, childhood sexual abuse, and intimate partner violence-on rates of HIV transmission risk behavior (TRB) and separately, transactional sex among transgender women. TRB was defined as the number of condomless penetrative sex events with a casual or main partner of discordant or unknown HIV status. Using data from 212 transgender women in New York City, multivariable analyses revealed that, compared to those with no syndemic conditions, dramatically higher rates of recent HIV TRB events (ARR = 8...
March 27, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29587791/sexual-and-reproductive-health-behavior-and-unmet-needs-among-a-sample-of-adolescents-living-with-hiv-in-zambia-a-cross-sectional-study
#18
Sumiyo Okawa, Sylvia Mwanza-Kabaghe, Mwiya Mwiya, Kimiyo Kikuchi, Masamine Jimba, Chipepo Kankasa, Naoko Ishikawa
BACKGROUND: Adolescents living with HIV face challenges, such as disclosure of HIV status, adherence to antiretroviral therapy, mental health, and sexual and reproductive health (SRH). These challenges affect their future quality of life. However, little evidence is available on their sexual behaviors and SRH needs in Zambia. This study aimed at assessing their sexual behaviors and SRH needs and identifying factors associated with marriage concerns and a desire to have children. METHODS: This cross-sectional study was conducted at the University Teaching Hospital from April to July 2014...
March 27, 2018: Reproductive Health
https://www.readbyqxmd.com/read/29576257/mortality-outcomes-based-on-ed-qsofa-score-and-hiv-status-in-a-developing-low-income-country
#19
Adam R Aluisio, Stephanie Garbern, Tess Wiskel, Zeta A Mutabazi, Olivier Umuhire, Chin Chin Ch'ng, Kristina E Rudd, Jeanne D'Arc Nyinawankusi, Jean Claude Byiringiro, Adam C Levine
OBJECTIVE: To evaluate the utility of the quick Sepsis-related Organ Failure Assessment (qSOFA) score to predict risks for emergency department (ED) and hospital mortality among patients in a sub-Saharan Africa (SSA) setting. METHODS: This retrospective cohort study was carried out at a tertiary-care hospital, in Kigali, Rwanda and included patients ≥15years, presenting for ED care during 2013 with an infectious disease (ID). ED and overall hospital mortality were evaluated using multivariable regression, with qSOFA scores as the primary predictor (reference: qSOFA=0), to yield adjusted relative risks (aRR) with 95% confidence intervals (CI)...
March 10, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29574739/reimagining-the-environment-in-developmental-psychopathology-from-molecules-to-effective-interventions
#20
EDITORIAL
Pasco Fearon
The Journal of Child Psychology and Psychiatry's Annual Research Review (ARR) is a must-read special issue of the journal that presents a series of major reviews of key topics in the field. This year the ARR consists of eight reviews, each accompanied by a commentary from a leading expert in the field, on a diverse range of topics addressing, in complementary ways, the key role of the environment in child psychopathology and in leveraging change in the service of prevention and intervention. Topics include epigenetics, stress physiology, neonatal imaging, interparental conflict, bullying, autism treatments and suicide...
April 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
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