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Liquor biomarkers

Aleksey Kulesh, Viktor Drobakha, Elena Kuklina, Irina Nekrasova, Vladimir Shestakov
BACKGROUND: Post-stroke cognitive impairment is a clinically heterogeneous condition and its types have a different course and prognosis. The aim of the present study is to address the roles of inflammation, white matter pathology, and brain atrophy in different neuropsychological types of cognitive impairment in the acute period of ischemic stroke. METHODS: In 92 patients, we performed an assessment of the cognitive status and measured concentrations of cytokines (interleukin [IL]-1β, IL-6, tumor necrosis factor-alpha, IL-10) in liquor and serum, as well as a number of magnetic resonance imaging (MRI) morphometric parameters and fractional anisotropy...
July 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Giulia A M Dolci, Sarah Damanti, Valeria Scortichini, Alessandro Galli, Paolo D Rossi, Carlo Abbate, Beatrice Arosio, Daniela Mari, Andrea Arighi, Giorgio G Fumagalli, Elio Scarpini, Silvia Inglese, Maura Marcucci
Background: The role of cerebrospinal fluid (CSF) biomarkers, and neuroimaging in the diagnostic process of Alzheimer's disease (AD) is not clear, in particular in the older patients. Objective: The aim of this study was to compare the clinical diagnosis of AD with CSF biomarkers and with cerebrovascular damage at neuroimaging in a cohort of geriatric patients. Methods: Retrospective analysis of medical records of ≥65-year-old patients with cognitive impairment referred to an Italian geriatric outpatient clinic, for whom the CSF concentration of amyloid-β (Aβ), total Tau (Tau), and phosphorylated Tau (p-Tau) was available...
2017: Frontiers in Medicine
Xiao-Wei Zheng, Zheng Yan, M J Robert Nout, Teun Boekhout, Bei-Zhong Han, Marcel H Zwietering, Eddy J Smid
Daqu is a fermentative saccharification agent that is used to initiate fermentation in the production of Chinese liquor and vinegar. Different types of Daqu can be distinguished based on the maximum fermentation temperature, location of production, and raw materials used. We aimed to characterize and distinguish the different types of Daqu using a culture-independent cloning method. The lowest microbial diversity was found in Daqu produced at high-temperature. Principal component analysis (PCA) was used to compare the bacterial composition of Daqu from different regions (i...
January 2015: World Journal of Microbiology & Biotechnology
Roberto Santangelo, Elisabetta Coppi, Laura Ferrari, Maria Paola Bernasconi, Patrizia Pinto, Gabriella Passerini, Giancarlo Comi, Giuseppe Magnani
BACKGROUND: Three variants of primary progressive aphasia (PPA) have been currently characterized: non fluent/agrammatic (nfv-PPA), semantic (sv-PPA), and logopenic variant (lv-PPA). lv-PPA is most commonly associated with Alzheimer's disease (AD), while nfv-PPA and sv-PPA are related to frontotemporal lobar degeneration. OBJECTIVE: We aimed to determine whether cerebrospinal fluid (CSF) amyloid-β42 (Aβ42), total tau protein (t-tau), and phosphorylated tau (p-tau), frequently abnormal in AD, could constitute a useful tool in the PPA diagnostic work up, in order to identify subjects with an underlying AD pathology...
2015: Journal of Alzheimer's Disease: JAD
Nils von Neuhoff, Andreas Pich
The use of modern mass spectroscopy methods has made proteomics a promising new tool for the clinical diagnosis of cancer and other diseases. Because body fluids like plasma, serum or liquor can be analyzed, proteomics should be easily integrated into large clinical trials. However, before proteomics can be implemented, rigorous quality control is urgently needed. One of the major topics of proteomics is the search for specific biomarkers which can be used for the qualitative and quantitative judgment of a disease...
2005: Drug Discovery Today. Technologies
Kristin A Guertin, Steven C Moore, Joshua N Sampson, Wen-Yi Huang, Qian Xiao, Rachael Z Stolzenberg-Solomon, Rashmi Sinha, Amanda J Cross
BACKGROUND: Metabolomics is an emerging field with the potential to advance nutritional epidemiology; however, it has not yet been applied to large cohort studies. OBJECTIVES: Our first aim was to identify metabolites that are biomarkers of usual dietary intake. Second, among serum metabolites correlated with diet, we evaluated metabolite reproducibility and required sample sizes to determine the potential for metabolomics in epidemiologic studies. DESIGN: Baseline serum from 502 participants in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial was analyzed by using ultra-high-performance liquid-phase chromatography with tandem mass spectrometry and gas chromatography-mass spectrometry...
July 2014: American Journal of Clinical Nutrition
Antonio Chiaretti, Antonio Ruggiero, Paola Coccia, Alessia Antonelli, Filomena Pierri, Giovanni Barone, Giorgio Attinà, Laura Iuvone, Palma Maurizi, Riccardo Riccardi
Brain damage related to intrathecal methotrexate in children with acute lymphoblastic leukemia (ALL) is still unclear. Neuroinflammatory mechanisms and intracerebral production of specific biomarkers, play a key role in determining neuroprotective mechanisms after brain injury. To determine whether the CSF concentrations of neuron-specific enolase (NSE), neurotrophic factors and doublecortin (DCX) are influenced by repeated intrathecal methotrexate administrations, we prospectively collected CSF samples from 10 children with ALL and 10 controls...
November 2011: Leukemia Research
Shangfu Li, Hongxia Liu, Yibao Jin, Shuhai Lin, Zongwei Cai, Yuyang Jiang
Alcohol abuse is one of the major causes of liver injury and a promoter for hepatocellular carcinoma (HCC). To understand the disease-associated metabolic changes, we investigated and compared the profiles of metabolites in nude mice with alcohol-induced liver injury or bearing a HCC xenograft (HCCX). Alcohol-induced liver injury was achieved by daily administration of grain liquor, and HCC xenografts were generated by subcutaneous inoculation of HepG2 cells in nude mice. Metabolites in serum samples were profiled by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF MS)...
August 15, 2011: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Inês D S Henriques, Diana S Aga, Pedro Mendes, Seamus K O'Connor, Nancy G Love
Metabolic footprinting coupled with statistical analysis was applied to multiple, chemically stressed activated sludge cultures to identify probable biomarkers that indicate community stress. The impact of cadmium (Cd), 2,4-dinitrophenol (DNP), and N-ethyl-maleimide (NEM) shock loads on the composition of the soluble fraction of activated sludge cultures was analyzed by gross biomolecular analyses and liquid chromatography-mass spectrometry (LC-MS). Fresh mixed liquor from four distinct treatment plants was each divided in four different batches and was subjected to no chemical addition (control) and spike additions of the stressors Cd, DNP, or NEM...
June 1, 2007: Environmental Science & Technology
Maneesha P Ginige, Philip Hugenholtz, Holger Daims, Michael Wagner, Jürg Keller, Linda L Blackall
A denitrifying microbial consortium was enriched in an anoxically operated, methanol-fed sequencing batch reactor (SBR) fed with a mineral salts medium containing methanol as the sole carbon source and nitrate as the electron acceptor. The SBR was inoculated with sludge from a biological nutrient removal activated sludge plant exhibiting good denitrification. The SBR denitrification rate improved from less than 0.02 mg of NO(3)(-)-N mg of mixed-liquor volatile suspended solids (MLVSS)(-1) h(-1) to a steady-state value of 0...
January 2004: Applied and Environmental Microbiology
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