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https://www.readbyqxmd.com/read/29212301/convergence-of-cancer-metabolism-and-immunity-an-overview
#1
REVIEW
Chi Van Dang, Jung-Whan Kim
Cancer metabolism as a field of research was founded almost 100 years ago by Otto Warburg, who described the propensity for cancers to convert glucose to lactate despite the presence of oxygen, which in yeast diminishes glycolytic metabolism known as the Pasteur effect. In the past 20 years, the resurgence of interest in cancer metabolism provided significant insights into processes involved in maintenance metabolism of non-proliferating cells and proliferative metabolism, which is regulated by proto-oncogenes and tumor suppressors in normal proliferating cells...
December 7, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/29211961/scalable-electron-correlation-methods-5-parallel-perturbative-triples-correction-for-explicitly-correlated-local-coupled-cluster-with-pair-natural-orbitals
#2
Qianli Ma, Hans-Joachim Werner
A well-parallelized perturbative triples correction implementation for the pair natural orbital based coupled cluster method PNO-LCCSD(T)-F12 is presented. A composite approach is adopted in addressing the coupling due to off-diagonal Fock matrix elements, in which the local triples amplitudes are iteratively solved using small domains of triples natural orbitals, and a semicanonical (T0) domain correction with larger domains is applied to the reduce the domain errors. This treatment adds only about 20% to the computational cost of (T0) calculations with large domains, and the errors due to the use of small domains in the iterations are very small...
December 6, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29193881/parent-knowledge-of-disease-management-in-cystic-fibrosis-assessing-behavioral-treatment-management
#3
Christina J Nicolais, Ruth Bernstein, Kristin A Riekert, Alexandra L Quittner
BACKGROUND: Cystic fibrosis (CF) is a life-shortening, burdensome disease requiring complex knowledge to manage the disease. Significant gaps in knowledge have been documented for parents, which may lead to unintentionally poor adherence and insufficient transfer of treatment responsibility from parents to adolescents. There are no current, validated measures of parent knowledge for this population and there are no measures that assess the knowledge required for day-to-day behavioral management of CF...
November 29, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29167076/the-convergence-of-two-epidemics-vitamin-d-deficiency-in-obese-school-aged-children
#4
REVIEW
Linda Cheng
PROBLEM: Vitamin D deficiency (VDD) and obesity are two interrelated global epidemics that affect school-aged children. This article will review the relationship between VDD and obesity in school-aged children and implications it has for the pediatric nurse (PN). ELIGIBILITY CRITERIA: Original articles of studies, review articles and meta-analyses were selected from the past 5years and pooled for review. These included obese school-aged children who had vitamin D insufficiency...
October 18, 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/29157679/the-generalized-problematic-internet-use-scale-2-in-a-french-sample-psychometric-evaluation-of-the-theoretical-model
#5
S Laconi, K Kaliszewska-Czeremska, N Tricard, H Chabrol, D J Kuss
OBJECTIVES: The Generalized Problematic Internet Use Scale-2 (GPIUS-2) is a short self-report questionnaire assessing Internet addiction based on a cognitive behavioral model. Our main goal was to evaluate the psychometric properties of its French version among a sample of students and to appraise the relevance of the generalized problematic Internet use model. METHODS: A sample of 563 university students aged between 18 and 35 years (M=20.8; SD=2.7) completed several online self-report questionnaires including the GPIUS-2, the Internet Addiction Test (IAT) and the Center for Epidemiologic Study-Depression scale (CES-D)...
November 17, 2017: L'Encéphale
https://www.readbyqxmd.com/read/29150866/the-minimum-test-battery-to-screen-for-binocular-vision-anomalies-report-3-of-the-band-study
#6
Jameel Rizwana Hussaindeen, Archayeeta Rakshit, Neeraj Kumar Singh, Meenakshi Swaminathan, Ronnie George, Suman Kapur, Mitchell Scheiman, Krishna Kumar Ramani
PURPOSE: This study aims to report the minimum test battery needed to screen non-strabismic binocular vision anomalies (NSBVAs) in a community set-up. When large numbers are to be screened we aim to identify the most useful test battery when there is no opportunity for a more comprehensive and time-consuming clinical examination. METHODS: The prevalence estimates and normative data for binocular vision parameters were estimated from the Binocular Vision Anomalies and Normative Data (BAND) study, following which cut-off estimates and receiver operating characteristic curves to identify the minimum test battery have been plotted...
November 18, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/29120861/preventing-relapse-to-smoking-with-transcranial-magnetic-stimulation-feasibility-and-potential-efficacy
#7
Christine E Sheffer, Warren K Bickel, Thomas H Brandon, Christopher T Franck, Darwin Deen, Luana Panissidi, Syed Amir Abdali, Jami C Pittman, Sara E Lunden, Neelam Prashad, Ria Malhotra, Antonio Mantovani
Many smokers attempt to quit every year, but 90% relapse within 12 months. Converging evidence suggests relapse is associated with insufficient activation of the prefrontal cortex. Delay discounting rate reflects relative activity in brain regions associated with relapse. High-frequency repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (LDLPFC) increases cortical excitability and reduces delay discounting rates, but little is known about feasibility, tolerability, and potential efficacy for smoking cessation...
November 4, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29119208/failures-in-adaptive-locomotion-trial-and-error-exploration-to-determine-adequate-foot-elevation-over-obstacles
#8
Michel J H Heijnen, Shirley Rietdyk
Lifting the limb sufficiently to clear an obstacle seems like a straightforward task, yet trips are a common cause of falls across all ages. Examination of obstacle contacts in the lab revealed a progressive decrease in foot elevation with repeated exposures, ultimately resulting in failure (Heijnen et al. Exp Brain Res 23:219-231, 2012). The purpose of this study was to determine if the progressive decrease in foot elevation continued when knowledge of obstacle contact was removed. Twenty-one young adults (mean 20...
November 8, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29105817/loss-of-spry1-attenuates-vascular-smooth-muscle-proliferation-by-impairing-mitogen-mediated-changes-in-cell-cycle-regulatory-circuits
#9
Xuehui Yang, Yan Gong, Qing He, Jonathan D Licht, Lucy Liaw, Robert E Friesel
Signals from growth factors or mechanical stimuli converge to promote vascular smooth muscle cell (VSMC) migration and proliferation, key events in the pathogenesis of intimal hyperplasia upon vascular injury. Spry1, a regulator of receptor tyrosine kinases (RTK), plays a role in maintaining the contractile phenotype of VSMC. The aim of the current study was to determine the role of Spry1 in VSMC proliferation in vitro and injury induced neointimal hyperplasia in vivo. VSMC proliferation and neointima formation were evaluated in cultured human aortic SMC (hAoSMC) and ligation-induced injury of mouse carotid arteries from Spry1 gene targeted mice, and their corresponding wild type littermates...
November 6, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29076570/validity-and-reliability-of-the-japanese-version-of-the-care-transitions-measure
#10
Mai Yoshimura, Miho Sato, Naomi Sumi
OBJECTIVE: To evaluate the validity and reliability of the Japanese Version of the Care Transitions Measure (J-CTM-15). DESIGN: Questionnaire items were translated, and a longitudinal study was conducted. SETTING: Three urban hospitals: a special functioning hospital, a regional-designated cancer care hospital, and a private hospital in the northern part of Japan. PARTICIPANTS: Patients, aged 20 years and older, who were discharged from hospitals...
October 27, 2017: International Journal of Health Planning and Management
https://www.readbyqxmd.com/read/29059258/the-inventory-of-depressive-symptomatology-self-report-ids-sr-psychometric-properties-of-the-indonesian-version
#11
Retha Arjadi, Maaike H Nauta, Dharmayati B Utoyo, Claudi L H Bockting
BACKGROUND: Depression screening and examination in Indonesia are highly challenging due to the disproportionately low number of mental health professionals in comparison to the Indonesian population. Self-report questionnaires on depression are cost-effective and time-efficient. The current study investigates the psychometric properties of the Indonesian Inventory of Depressive Symptomatology Self Report (IDS-SR). METHODS: The participants were 904 Indonesians (aged 16-61; 50...
2017: PloS One
https://www.readbyqxmd.com/read/28993094/characterization-of-diplopia-in-non-demented-patients-with-parkinson-s-disease
#12
Katharina A Schindlbeck, Shideh Schönfeld, Wanda Naumann, David J Friedrich, André Maier, Charlotte Rewitzer, Fabian Klostermann, Frank Marzinzik
INTRODUCTION: Although diplopia is considered a frequent symptom of Parkinson's disease (PD), little is known about its clinical manifestation, associated mechanisms and treatment. Here we characterized binocular diplopia in non-demented PD patients in an interdisciplinary setting. METHODS: PD patients were prospectively screened for diplopia, visual hallucinations, problems with spatial perception, contrast sensitivity, presence of blurred vision, and history of ophthalmological comorbidities via interview...
September 29, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28985221/long-term-outcomes-of-augmented-unilateral-recess-resect-procedure-in-children-with-intermittent-exotropia
#13
Jin-Soo Kim, Hee Kyung Yang, Jeong-Min Hwang
BACKGROUND: Initial overcorrection after exotropia surgery has been considered as a desirable result. Recently, there had been several studies that reported better surgical results of augmented bilateral lateral rectus muscle recession procedure over the conventional procedure. OBJECTIVES: To compare the long-term results of augmented unilateral lateral rectus recession-medial rectus resection procedure (RR) with the original surgery in exotropic children. DATA EXTRACTION: A retrospective cohort study was performed on a total of 121 children with exotropia who underwent RR from February 2005 to December 2012 and were followed-up for at least 24 months...
2017: PloS One
https://www.readbyqxmd.com/read/28977122/-comprehensive-primary-care-and-segmented-health-systems-in-south-america
#14
Ligia Giovanella, Patty Fidelis de Almeida
The article analyzes recent reforms in primary health care in the South American countries, discussing the scope and challenges for establishing comprehensive primary health care in the region's health systems. The data sources were case studies conducted in 12 countries, and the analytical lines were the strategic components in the design and implementation of primary health care: national policy approaches, characteristics of financing, organization and provision, and the workforce in primary health care...
October 2, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28945646/efficacy-of-toric-contact-lenses-in-fitting-and-patient-reported-outcomes-in-contact-lens-wearers
#15
Stephanie M Cox, David A Berntsen, Katherine M Bickle, Jessica H Mathew, Daniel R Powell, B Kim Little, Kathrine Osborn Lorenz, Jason J Nichols
OBJECTIVES: To assess whether patient-reported measures are improved with soft toric contact lenses (TCLs) compared with soft spherical contact lenses (SCLs) and whether clinical time needed to fit TCL is greater than SCL. METHODS: Habitual contact lens wearers with vertexed spherical refraction +4.00 to +0.25 D or -0.50 to -9.00 D and cylinder -0.75 to -1.75 DC were randomly assigned to be binocularly fitted into a TCL or SCL, and masked to treatment assignment...
September 21, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28912110/the-genetics-of-congenitally-small-brains
#16
REVIEW
Sarah Duerinckx, Marc Abramowicz
Primary microcephaly (PM) refers to a congenitally small brain, resulting from insufficient prenatal production of neurons, and serves as a model disease for brain volumic development. Known PM genes delineate several cellular pathways, among which the centriole duplication pathway, which provide interesting clues about the cellular mechanisms involved. The general interest of the genetic dissection of PM is illustrated by the convergence of Zika virus infection and PM gene mutations on congenital microcephaly, with CENPJ/CPAP emerging as a key target...
September 12, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28890076/convergence-insufficiency-symptom-survey-scores-for-required-reading-versus-leisure-reading-in-school-age-children
#17
Tiana Y Clark, Robert A Clark
PURPOSE: To compare Convergence Insufficiency Symptom Survey scores for required reading for school versus scores for leisure reading. METHODS: At a single private practice, we surveyed 100 children with normal binocular vision using modified survey questions specifying either required reading or leisure reading as the near visual activity. Average total symptom scores and subscores for questions about discomfort, fatigue, impaired vision, and cognitive performance were analyzed using t tests; responses to individual questions were analyzed using Mann-Whitney U tests...
September 7, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28882500/convergence-insufficiency-relationship-to-reading-and-academic-performance
#18
Paul H Phillips
Patients with convergence insufficiency (CI) are often symptomatic during activities that require near fixation, such as reading. Indeed, CI has been associated with reading impairment and poor academic performance. However, these associations do not prove a causal relationship between these conditions. The current evidence regarding the relationship between CI and its treatment, reading ability, and academic performance is discussed.
September 4, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28866427/influence-of-neck-torsion-on-near-point-convergence-in-subjects-with-idiopathic-neck-pain
#19
Phoebe Giffard, Laura Daly, Julia Treleaven
BACKGROUND: People with neck pain (NP) experience sensorimotor and oculomotor deficits thought to be due to abnormal cervical afferent input. Convergence insufficiency (CI) measured by near point convergence (NPC) may be a feature in NP and neck torsion might help to differentiate a cervical cause. OBJECTIVES: This study aimed to investigate repeatability and reliability of NPC in neutral and torsion and compare between idiopathic NP and controls along with correlation to the Convergence Insufficiency Symptom Survey (CISS)...
August 26, 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/28862105/prevalence-of-convergence-insufficiency-type-symptomatology-in-parkinson-s-disease
#20
Caroline Law, Estefania Chriqui, Marie-Jeanne Kergoat, Bernard-Simon Leclerc, Michel Panisset, Elizabeth L Irving, Ronald B Postuma, Sylvain Chouinard, Hélène Kergoat
BACKGROUND: Individuals with Parkinson's disease (PD) often present with visual symptoms (e.g., difficulty in reading, double vision) that can also be found in convergence insufficiency (CI). Our objective was to estimate the prevalence of CI-type visual symptomatology in individuals with PD, in comparison with controls. METHODS: Participants ≥50 years with (n=300) and without (n=300) PD were recruited. They were administered the Convergence Insufficiency Symptom Survey (CISS-15) over the phone...
September 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
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