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Convergence insufficiency

Xun Sun, Thomas E Morrell, Haw Yang
Protein conformational changes are known to play important roles in assorted biochemical and biological processes. Driven by thermal motions of surrounding solvent molecules, such a structural remodeling often occurs stochastically. Yet, regardless of how random the conformational reconfiguration may appear, it could in principle be described by a linear combination of a set of orthogonal modes which, in turn, are contained in the intramolecular distance distributions. The central challenge is how to obtain the distribution...
October 13, 2016: Journal of Physical Chemistry. B
Pierre Sokoloff, Bernard Le Foll
This review updates the existing knowledge suggesting a role for the D3 receptor in schizophrenia and drug addiction. The D3 receptor is expressed in brain regions controlling reward, emotions, and motivation. Antipsychotics bind in vitro to the D3 receptor with similar affinity as to the D2 receptor, and occupancy of D3 receptors in vivo by these compounds given acutely at clinical dosage have been demonstrated in Positron Emission Tomography (PET) studies. The D3 receptor modulates glutamatergic pathways from the prefrontal cortex to subcortical areas, either directly by interacting with N-methyl-D-aspartate (NMDA) receptors in the nucleus accumbens, or indirectly by controlling dopamine release from ventral tegmental area neurons...
September 7, 2016: European Journal of Neuroscience
Zhong Lin, Balamurali Vasudevan, Su Jie Fang, Vishal Jhanji, Guang Yun Mao, Wei Han, Tie Ying Gao, Kenneth J Ciuffreda, Yuan Bo Liang
BACKGROUND: Chinese traditional "eye exercises of acupoints" have been advocated as a compulsory measure to reduce visual symptoms, as well as to retard the development of refractive error, among Chinese students for decades. The exercises are comprised of a 5-min, bilateral eye acupoint self-massage. This study evaluated the possible effect of these eye exercises among Chinese rural students. METHODS: Eight hundred thirty-six students (437 males, 52.3 %), aged 10...
2016: BMC Complementary and Alternative Medicine
(no author information available yet)
PURPOSE: To compare the effectiveness of home-based (HB) computer vergence/accommodative therapy (HB-C) to HB near target push-up therapy (HB-PU) and to HB placebo treatment (HB-P) among children aged 9 to <18 years with symptomatic convergence insufficiency (CI). METHODS: In this multicenter randomized clinical trial, participants were randomly assigned to computer therapy, near target push-ups, or placebo. All therapy was prescribed for 5 days per week at home...
August 30, 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
Amy L Davis, Erin M Harvey, J Daniel Twelker, Joseph M Miller, Tina Leonard-Green, Irene Campus
Purpose. To determine rate of convergence insufficiency (CI) and accommodative insufficiency (AI) and assess the relation between CI, AI, visual symptoms, and astigmatism in school-age children. Methods. 3rd-8th-grade students completed the Convergence Insufficiency Symptom Survey (CISS) and binocular vision testing with correction if prescribed. Students were categorized by astigmatism magnitude (no/low: <1.00 D, moderate: 1.00 D to <3.00 D, and high: ≥3.00 D), presence/absence of clinical signs of CI and AI, and presence of symptoms...
2016: Journal of Ophthalmology
Michael Gallaway, Mitchell Scheiman, G Lynn Mitchell
PURPOSE: To determine the frequency and types of vision disorders associated with concussion, and to determine the success rate of vision therapy for these conditions in two private practice settings. METHODS: All records over an 18-month period of patients referred for post-concussion vision problems were reviewed from two private practices. Diagnoses of vergence, accommodative, or eye movement disorders were based on pre-established, clinical criteria. Vision therapy was recommended based on clinical findings and symptoms...
August 8, 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
M Kageyama, Y Nakamura, S Kobayashi, K Yokoyama
: WHAT IS KNOWN ON THE SUBJECT?: Empowerment of family caregivers of adults with mental health issues has received increasing attention among mental health nurses in Japan and has been recognized as a new goal of family interventions. The Family Empowerment Scale (FES) was originally developed to measure the empowerment status of parents of children with emotional disorders. However, it was later applied to broader health issues. WHAT THIS PAPER ADDS TO EXISTING KNOWLEDGE?: We developed a Japanese version of the FES for family caregivers of adults with mental health issues (FES-AMJ) and examined the validity and reliability among parents...
October 2016: Journal of Psychiatric and Mental Health Nursing
John Y Yoritomo, Richard L Weaver
Inasmuch as ambient noise fields are often not fully diffuse the question arises as to how, or whether, noise cross-correlations converge to Green's function in practice. Well-known theoretical estimates suggest that the quality of convergence scales with the square root of the product of integration time and bandwidth. However, correlations from natural environments often show random features too large to be consistent with fluctuations from insufficient integration time. Here it is argued that empirical seismic correlations suffer in practice from spurious arrivals due to scatterers, and not from insufficient integration time...
July 2016: Journal of the Acoustical Society of America
Johannes Wappenschmidt, Simon J Sonntag, Martin Buesen, Sascha Gross-Hardt, Tim Kaufmann, Thomas Schmitz-Rode, Ruediger Autschbach, Andreas Goetzenich
Mechanical circulatory support can maintain a sufficient blood circulation if the native heart is failing. The first implantable devices were displacement pumps with membranes. They were able to provide a sufficient blood flow, yet, were limited because of size and low durability. Rotary pumps have resolved these technical drawbacks, enabled a growing number of mechanical circulatory support therapy and a safer application. However, clinical complications like gastrointestinal bleeding, aortic insufficiency, thromboembolic complications, and impaired renal function are observed with their application...
July 27, 2016: Annals of Biomedical Engineering
Mitchell M Scheiman, Henry Talasan, Gladys Lynn Mitchell, Tara L Alvarez
PURPOSE: To evaluate changes in objective measures of disparity vergence after office-based vision therapy (OBVT) for concussion-related convergence insufficiency (CI) and determine the feasibility of using this objective assessment as an outcome measure in a clinical trial. METHODS: This was a prospective, observational trial. All participants were treated with weekly OBVT with home reinforcement. Participants included two adolescents and three young adults with concussion-related, symptomatic CI...
July 23, 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
Joseph Samuel Conrad, G Lynn Mitchell, Marjean Taylor Kulp
PURPOSE: To prospectively evaluate the effectiveness of home-based computer vergence therapy for the treatment of binocular vision disorders in adults at least 3 months after an acquired brain injury. METHODS: Eligibility criteria included presence of binocular dysfunction characterized by receded near point of convergence (≥6 cm break), insufficient positive fusional vergence at near (failing Sheard's criterion or <15△ blur or break), insufficient negative fusional vergence at near (<12△ blur or break), and/or reduced vergence facility at near (<15 cycles per minute with 12△BO/3△BI)...
July 23, 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
R Rouger, K Reichel, F Malrieu, J P Masson, S Stoeckel
Neutral patterns of population genetic diversity in species with complex life cycles are difficult to anticipate. Cyclical parthenogenesis (CP), in which organisms undergo several rounds of clonal reproduction followed by a sexual event, is one such life cycle. Many species, including crop pests (aphids), human parasites (trematodes) or models used in evolutionary science (Daphnia), are cyclical parthenogens. It is therefore crucial to understand the impact of such a life cycle on neutral genetic diversity...
November 2016: Heredity
Jin Yang, Fagui Liu, Jianneng Cao, Liangming Wang
Mobile sinks can achieve load-balancing and energy-consumption balancing across the wireless sensor networks (WSNs). However, the frequent change of the paths between source nodes and the sinks caused by sink mobility introduces significant overhead in terms of energy and packet delays. To enhance network performance of WSNs with mobile sinks (MWSNs), we present an efficient routing strategy, which is formulated as an optimization problem and employs the particle swarm optimization algorithm (PSO) to build the optimal routing paths...
2016: Sensors
Kwan Hyuk Cho, Hee Weon Kim, Dong Gyu Choi, Joo Yeon Lee
BACKGROUND: The aim of this study was to investigate the type of exotropia (XT) based on the distance-near (D/N) difference in recurrent XT after bilateral lateral rectus (BLR) recession to treat intermittent XT (IXT) to look into the possibility of secondary convergence insufficiency (CI)-type strabismus. METHODS: A total of 121 patients with recurrent XT after BLR recession for basic-type and divergence excess (DE)-type IXT were retrospectively enrolled at a single institution...
2016: BMC Ophthalmology
Hande Taylan Sekeroglu, Kadriye Erkan Turan, Jale Karakaya, Emin Cumhur Sener, Ali Sefik Sanac
AIM: To compare a group of patients with consecutive exotropia with patients who had ≤10 prism diopters (PD) esotropia or no deviation postoperatively in terms of probable clinical risk factors for the development of consecutive exotropia. METHODS: The study recruited fourteen patients who developed consecutive exodeviation during follow-up period after the correction of esotropia who were categorized as group 1 and thirty-one patients who had still ≤10 PD esotropia or no deviation at the final visit that were considered as group 2...
2016: International Journal of Ophthalmology
Elizabeth A Brown
Employers are collecting and using their employees' health data, mined from wearable fitness devices and health apps, in new, profitable, and barely regulated ways. The importance of protecting employee health and fitness data will grow exponentially in the future. This is the moment for a robust discussion of how law can better protect employees from the potential misuse of their health data. While scholars have just begun to examine the problem of health data privacy, this Article contributes to the academic literature in three important ways...
2016: Yale Journal of Health Policy, Law, and Ethics
David R Howell, Michael O'Brien, Aparna Raghuram, William P Meehan
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Pengjiang Qian, Shouwei Sun, Yizhang Jiang, Kuan-Hao Su, Tongguang Ni, Shitong Wang, Raymond F Muzic
Conventional, soft-partition clustering approaches, such as fuzzy c-means (FCM), maximum entropy clustering (MEC) and fuzzy clustering by quadratic regularization (FC-QR), are usually incompetent in those situations where the data are quite insufficient or much polluted by underlying noise or outliers. In order to address this challenge, the quadratic weights and Gini-Simpson diversity based fuzzy clustering model (QWGSD-FC), is first proposed as a basis of our work. Based on QWGSD-FC and inspired by transfer learning, two types of cross-domain, soft-partition clustering frameworks and their corresponding algorithms, referred to as type-I/type-II knowledge-transfer-oriented c-means (TI-KT-CM and TII-KT-CM), are subsequently presented, respectively...
February 2016: Pattern Recognition
Sebastiano Bariselli, Stamatina Tzanoulinou, Christelle Glangetas, Clément Prévost-Solié, Luca Pucci, Joanna Viguié, Paola Bezzi, Eoin C O'Connor, François Georges, Christian Lüscher, Camilla Bellone
Haploinsufficiency of SHANK3, encoding the synapse scaffolding protein SHANK3, leads to a highly penetrant form of autism spectrum disorder. How SHANK3 insufficiency affects specific neural circuits and how this is related to specific symptoms remains elusive. Here we used shRNA to model Shank3 insufficiency in the ventral tegmental area of mice. We identified dopamine (DA) and GABA cell-type-specific changes in excitatory synapse transmission that converge to reduce DA neuron activity and generate behavioral deficits, including impaired social preference...
July 2016: Nature Neuroscience
Mana Hirano, Osamu Wada-Hiraike, Houju Fu, Nana Akino, Wataru Isono, Ayako Sakurabashi, Tomohiko Fukuda, Yoshihiro Morita, Michihiro Tanikawa, Yuichiro Miyamoto, Yoshihiro Nishi, Toshihiko Yanase, Miyuki Harada, Hajime Oishi, Tetsu Yano, Kaori Koga, Katsutoshi Oda, Kei Kawana, Tomoyuki Fujii, Yutaka Osuga
Germline mutations of the fork-head transcriptional factor forkhead box L2 (FOXL2) predispose embryos to autosomal-dominant blepharophimosis-ptosis-epicanthus inversus syndrome with primary ovarian insufficiency in female patients, but the mechanisms of FOXL2 in ovarian follicular development remain elusive. Estrogens produced by ovarian granulosa cells and estrogen receptor (ER) α and ERβ play fundamental roles in ovarian pathophysiology, and a previous study revealed that ERα and ERβ physically interact with FOXL2...
June 1, 2016: Reproductive Sciences
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