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Convergence insufficiency

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https://www.readbyqxmd.com/read/29431132/longitudinal-changes-in-oculomotor-function-in-young-adults-with-mild-traumatic-brain-injury-in-sweden-an-exploratory-prospective-observational-study
#1
Giedre Matuseviciene, Jan Johansson, Marika Möller, Alison K Godbolt, Tony Pansell, Catharina Nygren Deboussard
OBJECTIVES: To assess (1) whether visual disturbances can be demonstrated with objective measures more often in patients with mild traumatic brain injury (mTBI) than in orthopaedic controls and non-injured controls, (2) whether such objectively demonstrated disturbances change over time and (3) whether self-reported visual symptoms after mTBI correlate with objectively measurable changes in visuomotor performance. DESIGN: A prospective, controlled, observational study, with assessments planned 7-10 and 75-100 days after injury...
February 3, 2018: BMJ Open
https://www.readbyqxmd.com/read/29422214/evidence-based-national-guidelines-for-the-management-of-suspected-fetal-growth-restriction-comparison-consensus-and-controversy
#2
REVIEW
Lesley M McCowan, Francesc Figueras, Ngaire H Anderson
Small for gestational age is usually defined as an infant with a birthweight <10th centile for a population or customized standard. Fetal growth restriction refers to a fetus that has failed to reach its biological growth potential because of placental dysfunction. Small-for-gestational-age babies make up 28-45% of nonanomalous stillbirths, and have a higher chance of neurodevelopmental delay, childhood and adult obesity, and metabolic disease. The majority of small-for-gestational-age babies are not recognized before birth...
February 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29394043/ligand-binding-pathways-and-conformational-transitions-of-the-hiv-protease
#3
Yinglong Miao, Yu-Ming Huang, Ross C Walker, J Andrew McCammon, Chia-En A Chang
It is important to determine the binding pathways and mechanisms of ligand molecules to target proteins in order to effectively design therapeutic drugs. Molecular dynamics (MD) is a promising computational tool that allows us to simulate protein-drug binding at an atomistic level. However, the gap between timescales of current simulations and those of many drug binding processes has limited the usage of conventional MD, which has been reflected in studies of the HIV protease. Here, we have applied a robust enhanced simulation method, Gaussian accelerated molecular dynamics (GaMD), to sample binding pathways of the XK263 ligand and associated protein conformational changes in the HIV protease...
February 2, 2018: Biochemistry
https://www.readbyqxmd.com/read/29393127/uric-acid-renal-lithiasis-new-concepts
#4
Fabiola Pazos Pérez
BACKGROUND: Uric acid (UA) stones are responsible for 5-10% of the formation of all kidney stones. Recently, an association between UA stones and insulin resistance, diabetes mellitus, and obesity has been demonstrated and so the incidence has increased. The development of UA stones is dependent on several risk factors, including genetic predisposition, geographical location, dietary indiscretion, and various metabolic characteristics. SUMMARY: UA nephrolithiasis can arise from diverse etiologies, all with distinct underlying defects converging to one or more of 3 defects of hyperuricosuria, acidic urine pH, and low urinary volume...
2018: Contributions to Nephrology
https://www.readbyqxmd.com/read/29371010/the-discrepancy-between-subjective-and-objective-measures-of-convergence-insufficiency-in-whiplash-associated-disorder-versus-control-participants
#5
Hadas Stiebel-Kalish, Amir Amitai, Michael Mimouni, Michael Bach, Tal Saban, Michelle Cahn, Liat Gantz
PURPOSE: Motor vehicle accidents (MVAs) are a pandemic associated with human suffering and a burden to national economies. Whiplash-associated disorders (WADs) after MVAs are associated commonly with disability claims, many of which are related to vision. Convergence insufficiency (CI) leads to visual disability associated with symptoms of ocular discomfort. We examined the incidence of symptoms and findings consistent with CI in a cohort of patients after MVA-related WAD compared with age-matched control participants...
January 19, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29364897/slower-saccadic-reading-in-parkinson-s-disease
#6
Naz Jehangir, Caroline Yizhu Yu, Jeehey Song, Mohammad Ali Shariati, Steven Binder, Jill Beyer, Veronica Santini, Kathleen Poston, Yaping Joyce Liao
Idiopathic Parkinson's Disease (PD) is characterized by degeneration of dopaminergic and other neurons, leading to motor and non-motor deficits. Abnormal eye movements in PD, including fixations, saccades, and convergence, are well described. However, saccadic reading, which requires serial and alternating saccades and fixations, is not well studied, despite its obvious impact on the quality of life. In this study, we assessed saccadic reading using variations of the King-Devick (KD) test, a rapid single digit number naming test, as a way to assess the ability to make serial left-to-right ocular motor movements necessary for reading...
2018: PloS One
https://www.readbyqxmd.com/read/29308964/the-reliability-and-validity-of-the-standardized-mensendieck-test-in-relation-to-disability-in-patients-with-chronic-pain
#7
Paul Keessen, Jolanda Maaskant, Bart Visser
The standardized Mensendieck test (SMT) was developed to quantify posture, movement, gait, and respiration. In the hands of an experienced therapist, the SMT is proven to be a reliable tool. It is unclear whether posture, movement, gait, and respiration are related to the degree of functional disability in patients with chronic pain. The objective of this study was to assess the reliability and convergent validity of the SMT in a heterogeneous sample of 50 patients with chronic pain. METHODS: Internal consistency was determined by Cronbach's α and interrater reliability by the intraclass correlation coefficient (ICC)...
January 8, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29288676/transcriptomic-profiles-of-post-smolt-atlantic-salmon-challenged-with-piscirickettsia-salmonis-reveal-a-strategy-to-evade-the-adaptive-immune-response-and-modify-cell-autonomous-immunity
#8
Marco Rozas-Serri, Andrea Peña, Lucerina Maldonado
Piscirickettsiosis is the main bacterial disease affecting the Chilean salmon farming industry and is responsible for high economic losses. The development of effective strategies to control piscirickettsiosis has been limited in part by insufficient knowledge of the host response. The aim of this study was to use RNA sequencing to describe the transcriptional profiles of the responses of post-smolt Atlantic salmon infected with LF-89-like or EM-90-like Piscirickettsia salmonis. Enrichment and pathway analyses of the differentially expressed genes revealed several central signatures following infection, including positive regulation of DC-SIGN and TLR5 signalling, which converged at the NF-κB level to modulate the pro-inflammatory cytokine response, particularly in the PS-EM-90-infected fish...
December 27, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29246058/photoelectron-angular-distributions-from-rotationally-resolved-autoionizing-states-of-n2
#9
A M Chartrand, E F McCormack, U Jacovella, D M P Holland, B Gans, Xiaofeng Tang, G A Garcia, L Nahon, S T Pratt
The single-photon, photoelectron-photoion coincidence spectrum of N2 has been recorded at high (∼1.5 cm-1) resolution in the region between the N2+ X Σg2+, v+ = 0 and 1 ionization thresholds by using a double-imaging spectrometer and intense vacuum-ultraviolet light from the Synchrotron SOLEIL. This approach provides the relative photoionization cross section, the photoelectron energy distribution, and the photoelectron angular distribution as a function of photon energy. The region of interest contains autoionizing valence states, vibrationally autoionizing Rydberg states converging to vibrationally excited levels of the N2+ X Σg2+ ground state, and electronically autoionizing states converging to the N2+A2Π and B 2Σu+ states...
December 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29244028/adaptive-heart-rate-based-epileptic-seizure-detection-using-real-time-user-feedback
#10
Thomas De Cooman, Troels Wesenberg Kjær, Sabine Van Huffel, Helge Bjarup Dissing Sørensen
Automated seizure detection in a home environment has been of increased interest the last couple of decades. Heart rate-based seizure detection is a way to detect temporal lobe epilepsy seizures at home, but patient-independent algorithms showed to be insufficiently accurate due to the high patient-dependency of heart rate features. Therefore a real-time adaptive seizure detection algorithm is proposed here. The algorithm starts as a patient-independent algorithm, but gradually converges towards a patient-specific algorithm while more patient-specific data becomes available on-the-run...
December 15, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/29238556/reliable-effective-number-of-breeders-adult-census-size-ratios-in-seasonal-breeding-species-opportunity-for-integrative-demographic-inferences-based-on-capture-mark-recapture-data-and-multilocus-genotypes
#11
Gregorio Sánchez-Montes, Jinliang Wang, Arturo H Ariño, José Luis Vizmanos, Iñigo Martínez-Solano
The ratio of the effective number of breeders (Nb) to the adult census size (Na), Nb/Na, approximates the departure from the standard capacity of a population to maintain genetic diversity in one reproductive season. This information is relevant for assessing population status, understanding evolutionary processes operating at local scales, and unraveling how life-history traits affect these processes. However, our knowledge on Nb/Na ratios in nature is limited because estimation of both parameters is challenging...
December 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29224583/nutrients-for-neurocognition-in-health-and-disease-measures-methodologies-and-mechanisms
#12
Andrew Scholey
Effective pharmaceutical treatments for age-related cognitive decline have proved elusive. There is, however, compelling evidence that nutritional status and supplementation could play crucial roles in modifying the expression of cognitive change through the lifespan. Subjective memory impairment and mild cognitive impairment can be harbingers of dementia but this is by no means inevitable. Neurocognitive change is influenced by a variety of processes, many of which are involved in other aspects of systemic health, including cardiovascular function...
December 11, 2017: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/29212301/convergence-of-cancer-metabolism-and-immunity-an-overview
#13
REVIEW
Chi Van Dang, Jung-Whan Kim
Cancer metabolism as a field of research was founded almost 100 years ago by Otto Warburg, who described the propensity for cancers to convert glucose to lactate despite the presence of oxygen, which in yeast diminishes glycolytic metabolism known as the Pasteur effect. In the past 20 years, the resurgence of interest in cancer metabolism provided significant insights into processes involved in maintenance metabolism of non-proliferating cells and proliferative metabolism, which is regulated by proto-oncogenes and tumor suppressors in normal proliferating cells...
January 1, 2018: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/29211961/scalable-electron-correlation-methods-5-parallel-perturbative-triples-correction-for-explicitly-correlated-local-coupled-cluster-with-pair-natural-orbitals
#14
Qianli Ma, Hans-Joachim Werner
A well-parallelized perturbative triples correction implementation for the pair natural orbital based coupled cluster method PNO-LCCSD(T)-F12 is presented. A composite approach is adopted in addressing the coupling due to off-diagonal Fock matrix elements, in which the local triples amplitudes are iteratively solved using small domains of triples natural orbitals, and a semicanonical (T0) domain correction with larger domains is applied to the reduce the domain errors. This treatment adds only about 20% to the computational cost of (T0) calculations with large domains, and the errors due to the use of small domains in the iterations are very small...
December 6, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29193881/parent-knowledge-of-disease-management-in-cystic-fibrosis-assessing-behavioral-treatment-management
#15
Christina J Nicolais, Ruth Bernstein, Kristin A Riekert, Alexandra L Quittner
BACKGROUND: Cystic fibrosis (CF) is a life-shortening, burdensome disease requiring complex knowledge to manage the disease. Significant gaps in knowledge have been documented for parents, which may lead to unintentionally poor adherence and insufficient transfer of treatment responsibility from parents to adolescents. There are no current, validated measures of parent knowledge for this population and there are no measures that assess the knowledge required for day-to-day behavioral management of CF...
November 29, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29167076/the-convergence-of-two-epidemics-vitamin-d-deficiency-in-obese-school-aged-children
#16
REVIEW
Linda Cheng
PROBLEM: Vitamin D deficiency (VDD) and obesity are two interrelated global epidemics that affect school-aged children. This article will review the relationship between VDD and obesity in school-aged children and implications it has for the pediatric nurse (PN). ELIGIBILITY CRITERIA: Original articles of studies, review articles and meta-analyses were selected from the past 5years and pooled for review. These included obese school-aged children who had vitamin D insufficiency...
October 18, 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/29157679/the-generalized-problematic-internet-use-scale-2-in-a-french-sample-psychometric-evaluation-of-the-theoretical-model
#17
S Laconi, K Kaliszewska-Czeremska, N Tricard, H Chabrol, D J Kuss
OBJECTIVES: The Generalized Problematic Internet Use Scale-2 (GPIUS-2) is a short self-report questionnaire assessing Internet addiction based on a cognitive behavioral model. Our main goal was to evaluate the psychometric properties of its French version among a sample of students and to appraise the relevance of the generalized problematic Internet use model. METHODS: A sample of 563 university students aged between 18 and 35 years (M=20.8; SD=2.7) completed several online self-report questionnaires including the GPIUS-2, the Internet Addiction Test (IAT) and the Center for Epidemiologic Study-Depression scale (CES-D)...
November 17, 2017: L'Encéphale
https://www.readbyqxmd.com/read/29150866/the-minimum-test-battery-to-screen-for-binocular-vision-anomalies-report-3-of-the-band-study
#18
Jameel Rizwana Hussaindeen, Archayeeta Rakshit, Neeraj Kumar Singh, Meenakshi Swaminathan, Ronnie George, Suman Kapur, Mitchell Scheiman, Krishna Kumar Ramani
PURPOSE: This study aims to report the minimum test battery needed to screen non-strabismic binocular vision anomalies (NSBVAs) in a community set-up. When large numbers are to be screened we aim to identify the most useful test battery when there is no opportunity for a more comprehensive and time-consuming clinical examination. METHODS: The prevalence estimates and normative data for binocular vision parameters were estimated from the Binocular Vision Anomalies and Normative Data (BAND) study, following which cut-off estimates and receiver operating characteristic curves to identify the minimum test battery have been plotted...
November 18, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/29120861/preventing-relapse-to-smoking-with-transcranial-magnetic-stimulation-feasibility-and-potential-efficacy
#19
Christine E Sheffer, Warren K Bickel, Thomas H Brandon, Christopher T Franck, Darwin Deen, Luana Panissidi, Syed Amir Abdali, Jami C Pittman, Sara E Lunden, Neelam Prashad, Ria Malhotra, Antonio Mantovani
Many smokers attempt to quit every year, but 90% relapse within 12 months. Converging evidence suggests relapse is associated with insufficient activation of the prefrontal cortex. Delay discounting rate reflects relative activity in brain regions associated with relapse. High-frequency repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (LDLPFC) increases cortical excitability and reduces delay discounting rates, but little is known about feasibility, tolerability, and potential efficacy for smoking cessation...
November 4, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29119208/failures-in-adaptive-locomotion-trial-and-error-exploration-to-determine-adequate-foot-elevation-over-obstacles
#20
Michel J H Heijnen, Shirley Rietdyk
Lifting the limb sufficiently to clear an obstacle seems like a straightforward task, yet trips are a common cause of falls across all ages. Examination of obstacle contacts in the lab revealed a progressive decrease in foot elevation with repeated exposures, ultimately resulting in failure (Heijnen et al. Exp Brain Res 23:219-231, 2012). The purpose of this study was to determine if the progressive decrease in foot elevation continued when knowledge of obstacle contact was removed. Twenty-one young adults (mean 20...
November 8, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
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