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Convergence insufficiency

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https://www.readbyqxmd.com/read/28212875/genotyping-by-sequencing-provides-the-first-well-resolved-phylogeny-for-coffee-coffea-and-insights-into-the-evolution-of-caffeine-content-in-its-species-gbs-coffee-phylogeny-and-the-evolution-of-caffeine-content
#1
Perla Hamon, Corrinne E Grover, Aaron P Davis, Jean-Jacques Rakotomalala, Nathalie E Raharimalala, Victor A Albert, Hosahalli L Sreenath, Piet Stoffelen, Sharon E Mitchell, Emmanuel Couturon, Serge Hamon, Alexandre de Kochko, Dominique Crouzillat, Michel Rigoreau, Ucu Sumirat, Sélastique Akaffou, Romain Guyot
A comprehensive and meaningful phylogenetic hypothesis for the commercially important coffee genus (Coffea) has long been a key objective for coffee researchers. For molecular studies, progress has been limited by low levels of sequence divergence, leading to insufficient topological resolution and statistical support in phylogenetic trees, particularly for the major lineages and for the numerous species occurring in Madagascar. We report here the first almost fully resolved, broadly sampled phylogenetic hypothesis for coffee, the result of combining genotyping-by-sequencing (GBS) technology with a newly developed, lab-based workflow to integrate short read next-generation sequencing for low numbers of additional samples...
February 14, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28132818/salt-inducible-kinase-3-provides-sugar-tolerance-by-regulating-nadph-nadp-redox-balance
#2
Mari Teesalu, Bohdana M Rovenko, Ville Hietakangas
Nutrient-sensing pathways respond to changes in the levels of macronutrients, such as sugars, lipids, or amino acids, and regulate metabolic pathways to maintain organismal homeostasis [1, 2]. Consequently, nutrient sensing provides animals with the metabolic flexibility necessary for enduring temporal fluctuations in nutrient intake. Recent studies have shown that an animal's ability to survive on a high-sugar diet is determined by sugar-responsive gene regulation [3-8]. It remains to be elucidated whether other levels of metabolic control, such as post-translational regulation of metabolic enzymes, also contribute to organismal sugar tolerance...
February 6, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28126262/changes-in-stimulus-and-response-ac-a-ratio-with-vision-therapy-in-convergence-insufficiency
#3
Neeraj Kumar Singh, Revathy Mani, Jameel Rizwana Hussaindeen
PURPOSE: To evaluate the changes in the stimulus and response Accommodative Convergence to Accommodation (AC/A) ratio following vision therapy (VT) in Convergence Insufficiency (CI). METHODS: Stimulus and response AC/A ratio were measured on twenty five CI participants, pre and post 10 sessions of VT. Stimulus AC/A ratio was measured using the gradient method and response AC/A ratio was calculated using modified Thorington technique with accommodative responses measured using WAM-5500 open-field autorefractor...
January 23, 2017: Journal of Optometry
https://www.readbyqxmd.com/read/28094981/gw100-a-plane-wave-perspective-for-small-molecules
#4
Emanuele Maggio, Peitao Liu, Michiel J van Setten, Georg Kresse
In a recent work, van Setten and co-workers have presented a carefully converged G0W0 study of 100 closed shell molecules [ J. Chem. Theory Comput. 2015 , 11 , 5665 - 5687 ]. For two different codes they found excellent agreement to within a few 10 meV if identical Gaussian basis sets were used. We inspect the same set of molecules using the projector augmented wave method and the Vienna ab initio simulation package (VASP). For the ionization potential, the basis set extrapolated plane wave results agree very well with the Gaussian basis sets, often reaching better than 50 meV agreement...
January 31, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28089390/quantitative-evaluation-of-the-in-vivo-vocal-fold-medial-surface-shape
#5
Andrew M Vahabzadeh-Hagh, Zhaoyan Zhang, Dinesh K Chhetri
OBJECTIVES/HYPOTHESIS: Glottal insufficiency is a common clinical problem in otolaryngology and medialization laryngoplasty (ML) procedures remain the primary treatment modality. Although the goal of ML is to restore physiologic glottal posture and achieve optimal phonation, this posture has not been directly measured. In this study, we assessed glottal medial surface contour changes with selective activation of the intrinsic laryngeal muscles (ILMs). STUDY DESIGN: Basic science study using an in vivo canine hemilarynx model...
January 12, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28079738/vision-problems-and-reduced-reading-outcomes-in-queensland-schoolchildren
#6
Shelley Hopkins, Geoff P Sampson, Peter L Hendicott, Joanne M Wood
PURPOSE: To assess the relationship between vision and reading outcomes in Indigenous and non-Indigenous schoolchildren to determine whether vision problems are associated with lower reading outcomes in these populations. METHODS: Vision testing and reading assessments were performed on 508 Indigenous and non-Indigenous schoolchildren in Queensland, Australia divided into two age groups: Grades 1 and 2 (6-7 years of age) and Grades 6 and 7 (12-13 years of age). Vision parameters measured included cycloplegic refraction, near point of convergence, heterophoria, fusional vergence range, rapid automatized naming, and visual motor integration...
January 12, 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28069468/children-with-dorsal-midbrain-syndrome-as-a-result-of-pineal-tumors
#7
Mary Ellen Hoehn, Julie Calderwood, Thomas O'Donnell, Gregory T Armstrong, Amar Gajjar
BACKGROUND: Dorsal midbrain syndrome (also known as Parinaud syndrome and pretectal syndrome) is a well-known complication of tumors of the pineal region. However, there are few reports regarding outcomes, especially in children. The purpose of this study was to report the ophthalmic outcomes in a group of children with pineal tumors treated at a single institution. METHODS: The medical records of pediatric patients diagnosed with pineal region tumors and evaluated at our ophthalmology clinic were studied retrospectively...
January 7, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28059865/efferent-vision-therapy
#8
Janet C Rucker, Paul H Phillips
BACKGROUND: Traditional orthoptic therapy used by ophthalmologists, orthoptists, and optometrists is directed at improving visual acuity, ocular alignment, or both. For example, convergence exercises are used to treat convergence insufficiency (CI). However, other forms of "vision therapy" are directed at improving "visual processing and efficiency." The therapeutic regimen often entails repetitive ocular motor tasks performed during multiple office visits with a behavioral optometrist...
January 4, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28055920/robust-dlpp-with-nongreedy-%C3%A2-%C3%A2-norm-minimization-and-maximization
#9
Qianqian Wang, Quanxue Gao, Deyan Xie, Xinbo Gao, Yong Wang
Recently, discriminant locality preserving projection based on L1-norm (DLPP-L1) was developed for robust subspace learning and image classification. It obtains projection vectors by greedy strategy, i.e., all projection vectors are optimized individually through maximizing the objective function. Thus, the obtained solution does not necessarily best optimize the corresponding trace ratio optimization algorithm, which is the essential objective function for general dimensionality reduction. It results in insufficient recognition accuracy...
December 29, 2016: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/27932281/nutcracker-syndrome-a-rare-cause-of-left-flank-pain-that-can-also-manifest-as-unexplained-pelvic-pain
#10
Jean-Marie Berthelot, Frédéric Douane, Yves Maugars, Eric Frampas
Nutcracker syndrome (NCS) is symptomatic unilateral renal venous hypertension due to compression of the left renal vein between the superior mesenteric artery and aorta (anterior NCS) or between the aorta and spine (posterior NCS). The left ovarian or spermatic vein empties into the left renal vein and is an additional site of venostasis in about half the cases of NCS. The presenting symptom of NCS in about half the cases is atypical left flank pain suggesting a disorder of the lower ribs or thoracolumbar spinal junction, particularly as the pain worsens with standing and increased lumbar lordosis...
December 5, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27929719/nad-the-convergence-of-dna-repair-and-mitophagy
#11
Evandro F Fang, Vilhelm A Bohr
ATM is a 350 kDa serine/threonine kinase best known for its role in DNA repair and multiple cellular homeostasis pathways. Mutation in ATM causes the disease ataxia telangiectasia (A-T) with clinical features including ataxia, severe cerebellar atrophy and Purkinje cell loss. In a cross-species study, using primary rat neurons, the roundworm C. elegans, and a mouse model of A-T, we showed that loss of ATM induces mitochondrial dysfunction and compromised mitophagy due to NAD(+) insufficiency. Remarkably, NAD(+) repletion mitigates both the DNA repair defect and mitochondrial dysfunction in ATM-deficient neurons...
February 2017: Autophagy
https://www.readbyqxmd.com/read/27928407/vergence-neural-pathways-a-systematic-narrative-literature-review
#12
REVIEW
Annabelle Searle, Fiona J Rowe
Research in the neural pathway for vergence is less understood in comparison to the other four visual eye movements. The aim of this study was to review the literature on vergence neural pathways and associated disorders. A review of previous published literature though to March 2016 was conducted. Intracranial pathologies that affect entire neural functioning were found to cause convergence insufficiencies. In contrast, pathologies with a more localised intracranial lesion cause more specific vergence disorders...
October 2016: Neuro-ophthalmology
https://www.readbyqxmd.com/read/27875025/adherence-and-barriers-to-hyperinsufflation-in-children-with-congenital-muscular-dystrophy
#13
John E Pascoe, Hemant Sawnani, Oscar H Mayer, Keith McConnell, Joseph M McDonough, Cynthia White, Anne M Rutkowski, Raouf S Amin, Avani C Modi
BACKGROUND: Congenital muscular dystrophy (CMD) is a rare, inherited neuromuscular disease characterized by progressive muscle weakness, thoracic insufficiency, and ultimately respiratory failure. Adherence to respiratory therapies in children with neuromuscular disorders is unknown. This study examined the multimodal assessment of adherence and barriers to 15 min, twice daily hyperinsufflation in children with CMD. Adherence was hypothesized to be greater than 50% and discomfort, embarrassment, and difficulty finding time were hypothesized to be barriers...
November 22, 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27859646/prevalence-of-non-strabismic-anomalies-of-binocular-vision-in-tamil-nadu-report-2-of-band-study
#14
Jameel Rizwana Hussaindeen, Archayeeta Rakshit, Neeraj Kumar Singh, Ronnie George, Meenakshi Swaminathan, Suman Kapur, Mitchell Scheiman, Krishna Kumar Ramani
BACKGROUND: Population-based studies on the prevalence of non-strabismic anomalies of binocular vision in ethnic Indians are more than two decades old. Based on indigenous normative data, the BAND (Binocular Vision Anomalies and Normative Data) study aims to report the prevalence of non-strabismic anomalies of binocular vision among school children in rural and urban Tamil Nadu. METHODS: This population-based, cross-sectional study was designed to estimate the prevalence of non-strabismic anomalies of binocular vision in the rural and urban population of Tamil Nadu...
November 18, 2016: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/27843485/learning-latent-variable-gaussian-graphical-model-for-biomolecular-network-with-low-sample-complexity
#15
Yanbo Wang, Quan Liu, Bo Yuan
Learning a Gaussian graphical model with latent variables is ill posed when there is insufficient sample complexity, thus having to be appropriately regularized. A common choice is convex ℓ1 plus nuclear norm to regularize the searching process. However, the best estimator performance is not always achieved with these additive convex regularizations, especially when the sample complexity is low. In this paper, we consider a concave additive regularization which does not require the strong irrepresentable condition...
2016: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/27823719/individual-and-socio-demographic-factors-related-to-presenting-problem-and-diagnostic-impressions-at-a-pediatric-sleep-clinic
#16
Sonia L Rubens, Kristina E Patrick, Ariel A Williamson, Melisa Moore, Jodi A Mindell
OBJECTIVE: Individual and socio-demographic factors have been found to be associated with sleep disturbances in children. Few studies have examined these factors among children presenting for care at pediatric sleep clinics. This study examined individual and socio-demographic factors in association with presenting problems and diagnostic impressions for new patients at an interdisciplinary pediatric sleep clinic. METHODS: Data were collected from electronic medical records of 207 consecutive patients (54% male, 59% White, Meanage = 7...
September 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27790467/nursing-instructor-and-students-perspectives-on-clinical-education-apprenticeship-problems
#17
Ali Hasanpour-Dehkordi, Masoumeh Shohani
INTRODUCTION: Different problems might lead to reduction in the efficiency of nursing students' apprenticeship education and solving those problems. AIM: This study was conducted to determine nursing internship problems from the perspective of trainers and students. MATERIALS AND METHODS: In this descriptive cross-sectional study, 20 trainers and 43 senior students of nursing were selected using census method. A researcher-made questionnaire was used to collect data...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27784281/hoarding-symptoms-among-psychiatric-outpatients-confirmatory-factor-analysis-and-psychometric-properties-of-the-saving-inventory-revised-si-r
#18
Siau Pheng Lee, Clarissa Ong, Vathsala Sagayadevan, Rebecca Ong, Edimansyah Abdin, Susan Lim, Janhavi Vaingankar, Louisa Picco, Swapna Verma, Siow Ann Chong, Mythily Subramaniam
BACKGROUND: The growing interest in problematic hoarding as an independent clinical condition has led to the development of the Saving Inventory-Revised (SI-R) to assess hoarding phenomenology. The SI-R is one of the most widely used instruments to measure hoarding symptoms; however, it lacks validation in non-Western samples. METHODS: The current study examined the construct, convergent, and discriminant validity of the SI-R among 500 outpatients at a psychiatric hospital in Singapore...
October 26, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27642672/extraction-of-protein-conformational-modes-from-distance-distributions-using-structurally-imputed-bayesian-data-augmentation
#19
Xun Sun, Thomas E Morrell, Haw Yang
Protein conformational changes are known to play important roles in assorted biochemical and biological processes. Driven by thermal motions of surrounding solvent molecules, such a structural remodeling often occurs stochastically. Yet, regardless of how random the conformational reconfiguration may appear, it could in principle be described by a linear combination of a set of orthogonal modes which, in turn, are contained in the intramolecular distance distributions. The central challenge is how to obtain the distribution...
October 13, 2016: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/27600596/the-dopamine-d3-receptor-a-quarter-century-later
#20
REVIEW
Pierre Sokoloff, Bernard Le Foll
This review updates the existing knowledge suggesting a role for the D3 receptor in schizophrenia and drug addiction. The D3 receptor is expressed in brain regions controlling reward, emotions, and motivation. Antipsychotics bind in vitro to the D3 receptor with similar affinity as to the D2 receptor, and occupancy of D3 receptors in vivo by these compounds given acutely at clinical dosage have been demonstrated in Positron Emission Tomography (PET) studies. The D3 receptor modulates glutamatergic pathways from the prefrontal cortex to subcortical areas, either directly by interacting with N-methyl-D-aspartate (NMDA) receptors in the nucleus accumbens, or indirectly by controlling dopamine release from ventral tegmental area neurons...
January 2017: European Journal of Neuroscience
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