keyword
https://read.qxmd.com/read/38652839/integrative-phytochemical-ligand-structure-based-drug-design-nephroprotective-potential-of-annona-muricata-flower-petals
#21
JOURNAL ARTICLE
Zacchaeus S Ololade, Olayinka F Onifade, John C Eze, Olawumi T Oyebanji, Anikeola C Olaniran, Iyaduni A Anuoluwa, Oluwatope O Idowu, Bessie E Tommy
This study was aimed at investigating the ability of extract of Annona muricata (AM) flower-petals in ameliorating the toxic effects of acetaminophen on the kidneys of albino rats. The biochemical results showed a marked increase in AM 200 mg (32.84 ± 0.14) and AM 400 mg (32.64 ± 0.78). Increase levels of total protein in AM 200 mg (77.00 ± 5.65) displays nephroprotective potential of the flower extract. Reduction of renal activities of serum urea in AM 400 mg group (6...
April 23, 2024: Natural Product Research
https://read.qxmd.com/read/38652837/selective-and-controlled-grafting-from-pvdf-based-materials-by-oxygen-tolerant-green-light-mediated-atrp
#22
JOURNAL ARTICLE
Piotr Mocny, Ting-Chih Lin, Rohan Parekh, Yuqi Zhao, Marek Czarnota, Mateusz Urbańczyk, Carmel Majidi, Krzysztof Matyjaszewski
Poly(vinylidene fluoride) (PVDF) shows excellent chemical and thermal resistance and displays high dielectric strength and unique piezoelectricity, which are enabling for applications in membranes, electric insulators, sensors, or power generators. However, its low polarity and lack of functional groups limit wider applications. While inert, PVDF has been modified by grafting polymer chains by atom transfer radical polymerization (ATRP), albeit via an unclear mechanism, given the strong C-F bonds. Herein, we applied eosin Y and green-light-mediated ATRP to modify PVDF-based materials...
April 23, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38652834/tunability-in-3-site-electronic-excitation-transfer-dynamics-insights-into-the-role-of-perturbative-coupling
#23
JOURNAL ARTICLE
Amit Kumar Upadhyay, Karthik Sasihithlu
Electronic excitation transfer dynamics in photosynthetic systems, including the Fenna-Matthews-Olson complex, are often modeled using the interaction picture of three two-level systems, also known as the 3-site system. Among the two possible configurations, uphill and downhill, a recent publication reported an intriguing correlation between population dynamics and the intersite coupling. Specifically, the uphill configuration has been shown to have a pronounced dependence on perturbations in the intersite coupling, whereas the downhill configuration displays negligible dependence...
April 23, 2024: Journal of Physical Chemistry. B
https://read.qxmd.com/read/38652830/how-a-single-5-ev-electron-can-induce-double-strand-breaks-in-dna-a-time-dependent-density-functional-theory-study
#24
JOURNAL ARTICLE
Anil Kumar, Michael D Sevilla, Leon Sanche
Low-energy (<20 eV) electrons (LEEs) can resonantly interact with DNA to form transient anions (TAs) of fundamental units, inducing single-strand breaks (SSBs), and cluster damage, such as double-strand breaks (DSBs). Shape resonances, which arise from electron capture in a previously unfilled orbital, can induce only a SSB, whereas a single core-excited resonance (i.e., two electrons in excited orbitals of the field of a hole) has been shown experimentally to cause cluster lesions. Herein, we show from time-dependent density functional theory (TDDFT) that a core-excited resonance can produce a DSB, i...
April 23, 2024: Journal of Physical Chemistry. B
https://read.qxmd.com/read/38652825/the-fastest-capillary-flow-in-root-like-networks-under-gravity
#25
JOURNAL ARTICLE
Peilong Wang, Jun Gao, Boqi Xiao, Gongbo Long, Qian Zheng, Dahua Shou
Capillary flow has garnered significant attention due to its unique dynamic characteristics that require no external force. Creating a quantitative analytical model to evaluate capillary flow behaviors in root-like networks is essential for enhancing fluid control properties in functional textiles. In this study, we explore the capillary dynamics within root-like networks under the influence of gravity and derive the most rapid capillary flow via structural optimization. The flow time in a capillary is dominated by the capillary pressure, viscous pressure loss, and gravity, each of which exhibits diverse sensitivities to the structures of root-like networks...
April 23, 2024: Langmuir: the ACS Journal of Surfaces and Colloids
https://read.qxmd.com/read/38652824/microphysiologically-engineered-vessel-tumor-model-to-investigate-vascular-transport-dynamics-of-immune-cells
#26
JOURNAL ARTICLE
Yuwen Zhao, Yue Wu, Khayrul Islam, Ratul Paul, Yuyuan Zhou, Xiaochen Qin, Qiying Li, Yaling Liu
Cancer immunotherapy has emerged as a promising therapeutic strategy to combat cancer effectively. However, it is hard to observe and quantify how this in vivo process happens. Three-dimensional (3D) microfluidic vessel-tumor models offer valuable capability to study how immune cells transport during cancer progression. We presented an advanced 3D vessel-supported tumor model consisting of the endothelial lumen and vessel network for the study of T cells' transportation. The process of T cell transport through the vessel network and interaction with tumor spheroids was represented and monitored in vitro...
April 23, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38652822/using-machine-learning-to-construct-the-blood-follicle-distribution-models-of-various-trace-elements-and-explore-the-transport-related-pathways-with-multiomics-data
#27
JOURNAL ARTICLE
Guohuan Zhang, Weinan Lin, Ning Gao, Changxin Lan, Mengyuan Ren, Lailai Yan, Bo Pan, Jia Xu, Bin Han, Ligang Hu, Yuanchen Chen, Tianxiang Wu, Lili Zhuang, Qun Lu, Bin Wang, Mingliang Fang
Permeabilities of various trace elements (TEs) through the blood-follicle barrier (BFB) play an important role in oocyte development. However, it has not been comprehensively described as well as its involved biological pathways. Our study aimed to construct a blood-follicle distribution model of the concerned TEs and explore their related biological pathways. We finally included a total of 168 women from a cohort of in vitro fertilization-embryo transfer conducted in two reproductive centers in Beijing City and Shandong Province, China...
April 23, 2024: Environmental Science & Technology
https://read.qxmd.com/read/38652820/connected-speech-fluency-in-poststroke-and-progressive-aphasia-a-scoping-review-of-quantitative-approaches-and-features
#28
JOURNAL ARTICLE
Claire Cordella, Lauren Di Filippo, Vijaya B Kolachalama, Swathi Kiran
PURPOSE: Speech fluency has important diagnostic implications for individuals with poststroke aphasia (PSA) as well as primary progressive aphasia (PPA), and quantitative assessment of connected speech has emerged as a widely used approach across both etiologies. The purpose of this review was to provide a clearer picture on the range, nature, and utility of individual quantitative speech/language measures and methods used to assess connected speech fluency in PSA and PPA, and to compare approaches across etiologies...
April 23, 2024: American Journal of Speech-language Pathology
https://read.qxmd.com/read/38652818/histopathological-evaluation-of-bipolar-and-microneedle-radiofrequency-energy-on-the-skin-and-fat-of-the-abdominal-region-of-the-rat
#29
JOURNAL ARTICLE
Caner Gelbal, Burak Ergün Tatar, Bengi Yilmaz, Yiğit Uyanikgil, Canberk Tomruk, Mehmet Bozkurt
BACKGROUND: Radiofrequency (RF)-based devices are frequently used in plastic surgeries. In the current literature, no comparative experimental study has demonstrated the histological and immunological effects of these devices that are frequently used in the facial area. In this study, we investigated the histological and immunological effects of Bipolar RF (BodyTite) and Microneedle RF (Morpheus 8) devices in the rat abdominal region. METHODS: 24 rats were used in this study...
April 23, 2024: Plastic and Reconstructive Surgery
https://read.qxmd.com/read/38652811/one-step-construction-of-closed-pores-enabling-high-plateau-capacity-hard-carbon-anodes-for-sodium-ion-batteries-closed-pore-formation-and-energy-storage-mechanisms
#30
JOURNAL ARTICLE
Chuang Qiu, Ang Li, Daping Qiu, Yawen Wu, Zhijie Jiang, Jiapeng Zhang, Jianqi Xiao, Renlu Yuan, Zipeng Jiang, Xuewei Liu, Xiaohong Chen, Huaihe Song
Closed pores play a crucial role in improving the low-voltage (<0.1 V) plateau capacity of hard carbon anodes for sodium-ion batteries (SIBs). However, the lack of simple and effective closed-pore construction strategies, as well as the unclear closed-pore formation mechanism, has severely hindered the development of high plateau capacity hard carbon anodes. Herein, we present an effective closed-pore construction strategy by one-step pyrolysis of zinc gluconate (ZG) and elucidate the corresponding mechanism of closed-pore formation...
April 23, 2024: ACS Nano
https://read.qxmd.com/read/38652785/diversity-is-diverse-social-justice-reparations-and-science
#31
JOURNAL ARTICLE
Lee Jussim
Because the term "diversity" has two related but different meanings, what authors mean when they use the term is inherently unclear. In its broad form, it refers to vast variety. In its narrow form, it refers to human demographic categories deemed deserving of special attention by social justice-oriented activists. In this article, I review Hommel's critique of Roberts et al. (2020), which, I suggest, essentially constitutes two claims: that Roberts et al.'s (2020) call for diversity in psychological science focuses exclusively on the latter narrow form of diversity and ignores the scientific importance of diversity in the broader sense, and ignoring diversity in the broader sense is scientifically unjustified...
May 2024: Perspectives on Psychological Science
https://read.qxmd.com/read/38652756/neurovascular-ultrasound-in-acute-stroke-emergency-department-applications
#32
REVIEW
Grigory Ostrovskiy, Alexandra S Reynolds, Aarti Sarwal
Acute stroke is one of the most common neurologic emergencies encountered by emergency clinicians. While point of care ultrasound has been a core part of emergency clinicians' training and practice for many years, the use of specialized ultrasound modalities in the care of acute ischemic stroke has not been as widely adopted. This review discusses the use of ultrasound in acute stroke, with a focus on applications of interest to emergency clinicians. Transcranial Doppler, carotid Doppler, microembolic signal detection, transthoracic echocardiography, evaluation for collateral circulation and optic nerve sheath diameter measurement are discussed in a case-based format, with a focus on practical applications for emergency clinicians...
April 25, 2024: Emergency Medicine Practice
https://read.qxmd.com/read/38652750/organ-delimited-gene-regulatory-networks-provide-high-accuracy-in-candidate-transcription-factor-selection-across-diverse-processes
#33
JOURNAL ARTICLE
Rajeev Ranjan, Sonali Srijan, Somaiah Balekuttira, Tina Agarwal, Melissa Ramey, Madison Dobbins, Rachel Kuhn, Xiaojin Wang, Karen Hudson, Ying Li, Kranthi Varala
Organ-specific gene expression datasets that include hundreds to thousands of experiments allow the reconstruction of organ-level gene regulatory networks (GRNs). However, creating such datasets is greatly hampered by the requirements of extensive and tedious manual curation. Here, we trained a supervised classification model that can accurately classify the organ-of-origin for a plant transcriptome. This K-Nearest Neighbor-based multiclass classifier was used to create organ-specific gene expression datasets for the leaf, root, shoot, flower, and seed in Arabidopsis thaliana ...
April 30, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38652749/low-latency-gravitational-wave-alert-products-and-their-performance-at-the-time-of-the-fourth-ligo-virgo-kagra-observing-run
#34
JOURNAL ARTICLE
Sushant Sharma Chaudhary, Andrew Toivonen, Gaurav Waratkar, Geoffrey Mo, Deep Chatterjee, Sarah Antier, Patrick Brockill, Michael W Coughlin, Reed Essick, Shaon Ghosh, Soichiro Morisaki, Pratyusava Baral, Amanda Baylor, Naresh Adhikari, Patrick Brady, Gareth Cabourn Davies, Tito Dal Canton, Marco Cavaglia, Jolien Creighton, Sunil Choudhary, Yu-Kuang Chu, Patrick Clearwater, Luke Davis, Thomas Dent, Marco Drago, Becca Ewing, Patrick Godwin, Weichangfeng Guo, Chad Hanna, Rachael Huxford, Ian Harry, Erik Katsavounidis, Manoj Kovalam, Alvin K Y Li, Ryan Magee, Ethan Marx, Duncan Meacher, Cody Messick, Xan Morice-Atkinson, Alexander Pace, Roberto De Pietri, Brandon Piotrzkowski, Soumen Roy, Surabhi Sachdev, Leo P Singer, Divya Singh, Marek Szczepanczyk, Daniel Tang, Max Trevor, Leo Tsukada, Verónica Villa-Ortega, Linqing Wen, Daniel Wysocki
Multimessenger searches for binary neutron star (BNS) and neutron star-black hole (NSBH) mergers are currently one of the most exciting areas of astronomy. The search for joint electromagnetic and neutrino counterparts to gravitational wave (GW)s has resumed with ALIGO's, AdVirgo's and KAGRA's fourth observing run (O4). To support this effort, public semiautomated data products are sent in near real-time and include localization and source properties to guide complementary observations. In preparation for O4, we have conducted a study using a simulated population of compact binaries and a mock data challenge (MDC) in the form of a real-time replay to optimize and profile the software infrastructure and scientific deliverables...
April 30, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38652747/c-di-amp-determines-the-hierarchical-organization-of-bacterial-rck-proteins
#35
JOURNAL ARTICLE
Rita Rocha, João M P Jorge, Celso M Teixeira-Duarte, Inês R Figueiredo-Costa, Tatiana B Cereija, Paula F Ferreira-Teixeira, Christina Herzberg, Jörg Stülke, João H Morais-Cabral
In bacteria, intracellular K+ is involved in the regulation of membrane potential, cytosolic pH, and cell turgor as well as in spore germination, environmental adaptation, cell-to-cell communication in biofilms, antibiotic sensitivity, and infectivity. The second messenger cyclic-di-AMP (c-di-AMP) has a central role in modulating the intracellular K+ concentration in many bacterial species, controlling transcription and function of K+ channels and transporters. However, our understanding of how this regulatory network responds to c-di-AMP remains poor...
April 30, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38652745/thermodynamic-crossovers-in-supercritical-fluids
#36
JOURNAL ARTICLE
Xinyang Li, Yuliang Jin
Can liquid-like and gas-like states be distinguished beyond the critical point, where the liquid-gas phase transition no longer exists and conventionally only a single supercritical fluid phase is defined? Recent experiments and simulations report strong evidence of dynamical crossovers above the critical temperature and pressure. Despite using different criteria, many existing theoretical explanations consider a single crossover line separating liquid-like and gas-like states in the supercritical fluid phase...
April 30, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38652733/magnesium-and-vitamin-d-in-long-covid-syndrome-do-they-help
#37
JOURNAL ARTICLE
Federica I Wolf, Valentina Trapani
Since the start of the COVID-19 pandemic, it has become increasingly clear that the disease can have relevant multisystemic and long-term effects, and several studies have attempted to identify key determinants of the disease course. Here we discuss recent evidence suggesting that, in long COVID patients, combined magnesium and vitamin D deficiencies associate with a higher number of clinical manifestations, as compared to patients with normal levels of both nutrients. We highlight the potential synergistic effects of these deficiencies and propose that future studies should explore a causal link with the risk of developing long COVID...
April 23, 2024: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
https://read.qxmd.com/read/38652729/how-does-the-online-innovation-community-climate-affect-the-user-s-value-co-creation-behavior-the-mediating-role-of-motivation
#38
JOURNAL ARTICLE
Qiong Tan, Juan Tan, Xiaohui Gao
Online Innovation Community (OIC) serves as a virtual space for users to exchange products and services, and share knowledge and information. Previous studies have indicated that community climate is an important factor affecting users' value co-creation behavior, however, the influencing process has not been clearly revealed from the perspective of motivation. In this study, we explored the relationship between online innovation community climate (supportive climate and controlling climate), user motivation and value co-creation behavior (user's participation behavior and user's citizenship behavior) based on the SOR model...
2024: PloS One
https://read.qxmd.com/read/38652727/intravitreal-dexamethasone-for-the-treatment-of-macular-edema-secondary-to-hydroxychloroquine-toxicity
#39
JOURNAL ARTICLE
Mariam Mathai, Alexander Zeleny, Bradley H Jacobsen, Richard A Garfinkel, Reshma Katira, Jordana G Fein
PURPOSE: Cystoid macular edema is a vision-threatening complication infrequently associated with hydroxychloroquine retinal toxicity. There are limited data on the best treatment for this pathology. METHODS: A retrospective case series is presented. RESULTS: In this series, we present three cases of cystoid macular edema in patients with diagnosed hydroxychloroquine maculopathy successfully treated with intravitreal dexamethasone implantation...
May 1, 2024: Retinal Cases & Brief Reports
https://read.qxmd.com/read/38652709/stabilization-of-a-photoradiated-naphthalene-diimide-based-organic-radical-anion-inside-a-peptide-based-gel-matrix-with-an-improvement-of-optoelectronic-properties
#40
JOURNAL ARTICLE
Niladri Hazra, Kousik Gayen, Purnadas Ghosh, Biswanath Hansda, Arindam Banerjee
An amino acid-conjugated naphthalene diimide (NDI)-based highly red fluorescent radical anion has been found in a water medium under the photoradiated condition. This molecule has failed to form the radical anion in the monomeric state; however, the J aggregation in the aqueous medium has ensured the formation of radical anion in the ambient condition after the irradiation of both sunlight and UV light exposure. Electron paramagnetic resonance (EPR) studies clearly suggest the formation of radical anions. Herein, the stability of the radical anion in the aqueous medium is only a few minutes as a small amount of shaking is enough to quench the radical anion in the solution state...
April 23, 2024: Langmuir: the ACS Journal of Surfaces and Colloids
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