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https://www.readbyqxmd.com/read/29677705/in-house-validation-and-small-scale-collaborative-study-to-evaluate-analytical-performances-of-multi-mycotoxin-screening-methods-based-on-liquid-chromatography-high-resolution-mass-spectrometry-case-study-fusarium-toxins-in-wheat
#1
Biancamaria Ciasca, Michelangelo Pascale, Valerio Guido Altieri, Francesco Longobardi, Michele Suman, Dante Catellani, Veronica M T Lattanzio
A strong trend toward using highly selective mass spectrometry technologies for screening of multiple mycotoxins has been observed in recent years. In the present study, the process of validation of a multi-mycotoxin screening method based on liquid chromatography high-resolution mass spectrometry method is presented. The method was intended for the simultaneous screening of the major Fusarium toxins (deoxynivalenol, 3- and 15-acetyl deoxynivalenol, T-2 and HT-2 toxins, zearalenone, enniatins A, A1, B, B1, beauvericin) in wheat...
April 20, 2018: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/29677704/morphology-of-a-hidden-tube-resin-injection-and-ct-scanning-reveal-the-three-dimensional-structure-of-the-spiracle-in-the-japanese-bullhead-shark-heterodontus-japonicus-chondrichthyes-heterodontiformes-heterodontidae
#2
Taketeru Tomita, Minoru Toda, Kei Miyamoto, Keiichi Ueda, Kazuhiro Nakaya
The spiracle of elasmobranchs (sharks, skates, and rays) is a gill-slit-derived tube located behind the eye. Its inner structure was well studied in the late nineteenth to early twentieth century, but its entire morphology has rarely been characterized and is poorly understood. The present study shows the three-dimensional morphology of the spiracular tube for the first time, using resin injection and CT scanning, in the Japanese bullhead shark. The spiracular tube is characterized by the presence of two caeca (dorsal and ventral spiracular caeca) on the medial wall of the spiracular tube and the presence of a pseudobranch on the anterior wall...
April 20, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29677691/iodine-status-of-pregnant-women-from-a-coastal-brazilian-state-after-the-reduction-in-recommended-iodine-concentration-in-table-salt-according-to-governmental-requirements
#3
Débora Ayres Saraiva, Nathalie Anne de Oliveira E Silva de Morais, Carolina Martins Corcino, Tatiana Martins Benvenuto Louro Berbara, Annie Schtscherbyna, Mischelle Santos, Heron Botelho, Mario Vaisman, Patrícia de Fátima Dos Santos Teixeira
OBJECTIVE: To evaluate iodine status among pregnant women from a coastal state after Brazilian governmental resolution reducing iodine concentrations in table salt. Secondarily, we correlated urinary iodine concentration (UIC) with thyroid volume and hormones. METHODS: Inductively coupled plasma mass spectrometry was used to assess UIC from 629 samples of 244 first trimester pregnant women. Thyroid ultrasound, serum thyroglobulin, thyrotropin, free thyroxine, and antithyroid antibodies were measured as iodine concentrations on samples of table salt from patient's home...
February 14, 2018: Nutrition
https://www.readbyqxmd.com/read/29677689/neural-and-behavioral-changes-after-the-use-of-hearing-aids
#4
Hanin Karawani, Kimberly A Jenkins, Samira Anderson
OBJECTIVE: Individuals with age-related hearing loss (ARHL) can restore some loss of the auditory function with the use of hearing aids (HAs). However, what remains unknown are the physiological mechanisms that underlie how the brain changes with exposure to amplified sounds though the use of HAs. We aimed to examine behavioral and physiological changes induced by HAs. METHODS: Thirty-five older-adults with moderate ARHL with no history of hearing aid use were fit with HAs tested in aided and unaided conditions, and divided into experimental and control groups...
April 7, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29677686/bicycle-helmets-to-wear-or-not-to-wear-a-meta-analyses-of-the-effects-of-bicycle-helmets-on-injuries
#5
Alena Høye
A meta-analysis has been conducted of the effects of bicycle helmets on serious head injury and other injuries among crash involved cyclists. 179 effect estimates from 55 studies from 1989-2017 are included in the meta-analysis. The use of bicycle helmets was found to reduce head injury by 48%, serious head injury by 60%, traumatic brain injury by 53%, face injury by 23%, and the total number of killed or seriously injured cyclists by 34%. Bicycle helmets were not found to have any statistically significant effect on cervical spine injury...
April 17, 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29677685/on-the-phylogenetic-position-of-the-genus-raphidocystis-haptista-centroplasthelida-with-notes-on-the-dimorphism-in-centrohelid-life-cycle
#6
Vasily V Zlatogursky, Daria Drachko, Vladimir I Klimov, Yegor Shishkin
Centrohelid heliozoan Raphidocystis glabra was reisolated for the first time after initial description and put into a clonal culture. Its correct identification was confirmed by scanning and transmission electron microscopy of scales. The first light microscopy data from the living cells were obtained. Phylogenetic analysis of its position using 18S rDNA sequences was also performed. This species branches inside of the Polyplacocystis clade, being closely related to the strain HLO4. The latter was isolated from the same sample with R...
April 5, 2018: European Journal of Protistology
https://www.readbyqxmd.com/read/29677681/pphb22-a-member-of-hd-zip-proteins-activates-ppdam1-to-regulate-bud-dormancy-transition-in-suli-pear-pyrus-pyrifolia-white-pear-group
#7
Qinsong Yang, Qingfeng Niu, Jianzhao Li, Xiaoyan Zheng, Yunjing Ma, Songling Bai, Yuanwen Teng
Homeodomain-leucine zipper (HD-Zip) proteins, which form one of the largest and most diverse families, regulate many biological processes in plants, including differentiation, flowering, vascular development, and stress signaling. Abscisic acid (ABA) has been proved to be one of the key regulators of bud dormancy and to influence several HD-Zip genes expression. However, the role of HD-Zip genes in regulating bud dormancy remains unclear. We identified 47 pear (P. pyrifolia White Pear Group) HD-Zip genes, which were classified into four subfamilies (HD-Zip I-IV)...
April 5, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29677680/transcriptomic-identification-of-salt-related-genes-and-de-novo-assembly-in-common-buckwheat-f-esculentum
#8
Qi-Huan Lu, Ya-Qi Wang, Jin-Nan Song, Hong-Bing Yang
Common buckwheat (F. esculentum), annually herbaceous crop, is prevalent in people's daily life with the increasing development of economics. Compared with wheat, it is highly praised with high content of rutin and flavonoid. Common buckwheat is recognized as healthy food with good taste, and the product price of which such as noodles, flour, bread and so on are higher than wheat, and the seeds of which are bigger than that of tartary buckwheat, so if common buckwheat are planted more widely, people will spend less money on this healthy and delicious food...
April 4, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29677675/nitrogen-use-efficiency-and-crop-production-patterns-of-regional-variation-in-the-united-states-1987-2012
#9
Dennis P Swaney, Robert W Howarth, Bongghi Hong
National-level summaries of crop production and nutrient use efficiency, important for international comparisons, only partially elucidate agricultural dynamics within a country. Agricultural production and associated environmental impacts in large countries vary significantly because of regional differences in crops, climate, resource use and production practices. Here, we review patterns of regional crop production, nitrogen use efficiency (NUE), and major inputs of nitrogen to US crops over 1987-2012, based on the Farm Resource Regions developed by the Economic Research Service (USDA-ERS)...
April 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29677670/the-response-of-lake-area-and-vegetation-cover-variations-to-climate-change-over-the-qinghai-tibetan-plateau-during-the-past-30years
#10
Zengxin Zhang, Juan Chang, Chong-Yu Xu, Yang Zhou, Yanhong Wu, Xi Chen, Shanshan Jiang, Zheng Duan
Lakes and vegetation are important factors of the Earth's hydrological cycle and can be called an "indicator" of climate change. In this study, long-term changes of lakes' area and vegetation coverage in the Qinghai-Tibetan Plateau (QTP) and their relations to the climate change were analyzed by using Mann-Kendall method during the past 30years. Results showed that: 1) the lakes' area of the QTP increased significantly during the past 30years as a whole, and the increasing rates have been dramatically sped up since the year of 2000...
April 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29677669/toxicological-interaction-of-multi-component-mixtures-to-vibrio-qinghaiensis-sp-q67-induced-by-at-least-three-components
#11
Ya-Qian Xu, Shu-Shen Liu, Ye Fan, Kai Li
It has been stated by researchers that the antibiotic polymyxin B sulfate (POL) is a key component inducing time-dependent antagonism in freshwater luminescent bacteria, Vibrio qinghaiensis sp.-Q67, exposed in the ternary mixture system of the ionic liquids, pesticide and antibiotics. However, the previous statement is limited to ternary and quaternary mixtures without considering situations such as the binary system. In order to prove the direct inducing of antagonism by POL in a more complete and systematic way, two categories of experiments (adding POL in non-antagonistic ternary system and decomposing antagonistic ternary system with POL into the binary system) have been conducted in this paper...
April 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29677665/development-and-prospects-of-standardization-in-the-german-municipal-wastewater-sector
#12
Claudia Freimuth, Mark Oelmann, Erwin Amann
Given the significance of wastewater treatment and disposal for society and the economy together with the omnipresence of standards in the sector, we studied the development and prospects of the rules governing standardization in the German municipal wastewater sector. We thereby provide a detailed description of sector-specific committee-based standardization and significantly contribute to the understanding of this complex arena. We find that the German Association for Water Wastewater and Waste (DWA) has significantly improved its rules on standardization over time by aligning them closer to the generally accepted superordinate standardization principles...
April 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29677663/haptic-based-perception-empathy-biofeedback-system-for-balance-rehabilitation-in-patients-with-chronic-stroke-concepts-and-initial-feasibility-study
#13
Kazuhiro Yasuda, Kenta Saichi, Naomi Kaibuki, Hiroaki Harashima, Hiroyasu Iwata
BACKGROUND: Most individuals have sensory disturbances post stroke, and these deficits contribute to post-stroke balance impairment. The haptic-based biofeedback (BF) system appears to be one of the promising tools for balance rehabilitation in patients with stroke, and the BF system can increase the objectivity of feedback and encouragement than that provided by a therapist. RESEARCH QUESTION: Studies in skill science indicated that feedback or encouragement from a coach or trainer enhances motor learning effect...
April 14, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29677652/cardiomyocytes-have-mosaic-patterns-of-protein-expression
#14
Tony Y Wang, Dongwong Lee, Karen Fox-Talbot, Dan E Arking, Aravinda Chakravarti, Marc K Halushka
Skeletal myocytes have well-established fast and slow twitch fibers with unique gene and protein specific expression patterns. By immunohistochemical staining, these show a mosaic pattern across myocytes. We hypothesized cardiac myocytes may behave similarly where some proteins are differentially expressed between mature cardiomyocytes. We utilized the tool HPASubC on over 52,000 cardiac images of the Human Protein Atlas to identify differential protein expression patterns by immunohistochemistry across the cardiomyocytes...
March 24, 2018: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/29677646/adjuvant-strategies-to-improve-vaccination-of-the-elderly-population
#15
REVIEW
Birgit Weinberger
Immunosenescence contributes to increased incidence and severity of many infections in old age and is responsible for impaired immunogenicity and efficacy of vaccines. Adjuvants are one strategy to enhance immunogenicity of vaccines. The oil-in-water emulsions MF59TM and AS03, as well as a virosomal vaccine have been licensed in seasonal or pandemic influenza vaccines and are/were used successfully in the elderly. AS01, a liposome-based adjuvant comprising two immunostimulants has recently been approved in a recombinant protein vaccine for older adults, which showed very high efficacy against herpes zoster in clinical trials...
April 17, 2018: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29677640/18%C3%AE-glycyrrhetinic-acid-mitigates-radiation-induced-skin-damage-via-nadph-oxidase-ros-p38mapk-and-nf-%C3%AE%C2%BAb-pathways
#16
Li Su, Zeng Wang, Fei Huang, Ruilong Lan, Xiuying Chen, Deping Han, Lurong Zhang, Weijian Zhang, Jinsheng Hong
Radiation-induced inflammation plays an important role in radiation-induced tissue injury. 18β-glycyrrhetinic acid (18β-GA) has shown an anti-inflammatory activity. This study aimed to assess the activity of 18β-GA against radiation-induced skin damage, and explore the underlying mechanisms. In vitro assay revealed 18β-GA treatment decreased the production of IL-1β, IL-6, PGE2 and decreased p38MAPK phosphorylation, DNA-binding activity of AP-1, and NF-κB activation in irradiated RAW264.7 macrophages. Additionally, 18β-GA suppressed NF-κB activation by inhibiting NF-κB/p65 and IκB-α phosphorylation and alleviated ROS overproduction in irradiated RAW264...
April 13, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29677638/gestational-glucocorticoid-exposure-disrupts-glucose-homeostasis-that-is-accompanied-by-increased-endoglin-and-dpp-4-activity-instead-of-gsk-3-in-rats
#17
Olufunto O Badmus, Olugbenga S Michael, Saheed Rabiu, Lawrence A Olatunji
Gestational glucocorticoid (GC) treatment has been associated with cardiometabolic disorder (CMD) in offspring's in later life. Elevated dipeptidyl peptidase-4 (DPP-4) activity, endoglin and glycogen synthase kinase-3 (GSK-3) has also been implicated in the development of insulin resistance (IR) and/or vascular inflammation. We aimed to investigate the impact of GC exposure on glucose metabolism and the circulating levels of inflammatory biomarkers, DPP-4 activity and GSK-3 in pregnant rats. Pregnant Wistar rats received either vehicle or dexamethasone (DEX; 0...
April 13, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29677635/synthesis-and-structure-activity-relationship-of-furoquinolinediones-as-inhibitors-of-tyrosyl-dna-phosphodiesterase-2-tdp2
#18
Le-Mao Yu, Zhu Hu, Yu Chen, Azhar Ravji, Sophia Lopez, Caroline B Plescia, Qian Yu, Hui Yang, Monica Abdelmalak, Sourav Saha, Keli Agama, Evgeny Kiselev, Christophe Marchand, Yves Pommier, Lin-Kun An
Tyrosyl-DNA phosphodiesterase 2 (TDP2) is a recently discovered enzyme specifically repairing topoisomerase II (TOP2)-mediated DNA damage. It has been shown that inhibition of TDP2 synergize with TOP2 inhibitors. Herein, we report the discovery of the furoquinolinedione chemotype as a suitable skeleton for the development of selective TDP2 inhibitors. Compound 1 was identified as a TDP2 inhibitor as a result of screening our in-house compound library for compounds selective for TDP2 vs. TDP1. Further SAR studies provide several selective TDP2 inhibitors at low-micromolar range...
April 12, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29677631/enhancement-of-monoclonal-antibody-production-after-single-and-combination-treatment-of-the-hybridoma-cells-with-all-trans-retinoic-acid-and-docosahexaenoic-acid-an-in-vitro-and-in-vivo-study
#19
Mohsen Rokni, Ali Reza Razavi, Fazel Shokri, Kazem Ahmadi Kia, Farid Solaymani-Mohammadi, Reza Chahardoli, Ali Akbar Saboor-Yaraghi
Murine hybridoma cells can produce monoclonal antibody (MAb) and the production of these antibodies in culture and peritoneum can be affected by different factors, including stimulants, inhibitors and supplements. Among these factors, the impact of micronutrients on the production of MAbs by mouse hybridoma cells has not fully been explored. In this study the murine hybridoma cells, M3C5, were cultured and treated with different concentrations of ATRA and DHA, alone, in combinations, and at different time of exposure...
April 17, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29677625/nitrogen-isotope-variations-of-ammonium-across-rain-events-implications-for-different-scavenging-between-ammonia-and-particulate-ammonium
#20
Xu-Dong Zheng, Xue-Yan Liu, Wei Song, Xin-Chao Sun, Cong-Qiang Liu
Enhanced ammonia (NH3 ) emissions and deposition caused negative effects on air quality and ecosystems. Precipitation is an efficient pathway to remove NH3 and particulate ammonium (p-NH4 + ) from the atmosphere into ecosystems. However, precipitation scavenging of p-NH4 + in chemical transport models has often considered fine p-NH4 + , with inadequate constraints on NH3 and coarse p-NH4 + . Based on distinct δ15 N values between NH3 and NH4 + in PM2.5 (particulate matters with aerodynamic diameters ≤ 2...
April 17, 2018: Environmental Pollution
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