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Acute coronary syndrome

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https://www.readbyqxmd.com/read/29928895/hdl-apoa-i-induces-the-expression-of-angiopoietin-like-4-angptl4-in-endothelial-cells-via-a-pi3k-akt-foxo1-signaling-pathway
#1
Dimitris Theofilatos, Panagiotis Fotakis, Efi Valanti, Despina Sanoudou, Vassilis Zannis, Dimitris Kardassis
BACKGROUND: High Density Lipoprotein (HDL) and its main protein component, apolipoprotein A-I (apoA-I) have numerous atheroprotective functions on various tissues including the endothelium. Therapies based on reconstituted HDL containing apoA-I (rHDL-apoA-I) have been used successfully in patients with acute coronary syndrome, peripheral vascular disease or diabetes but very little is known about the genomic effects of rHDL-apoA-I and how they could contribute to atheroprotection. OBJECTIVE: The present study aimed to understand the endothelial signaling pathways and the genes that may contribute to rHDL-apoA-I-mediated atheroprotection...
June 18, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29928315/non-vitamin-k-antagonist-oral-anticoagulant-after-acute-coronary-syndrome-is-there-a-role
#2
REVIEW
Paul Guedeney, Birgit Vogel, Roxana Mehran
Despite dual antiplatelet therapy (DAPT) including potent P2Y12 inhibitors, recurrent ischaemic events occur in a significant number of patients after acute coronary syndrome (ACS), warranting new antithrombotic strategies. Combinations of non-vitamin K antagonist oral anticoagulant (NOAC) with antiplatelet therapy have been tested in several large phases II and III randomised trials. Overall, current evidence suggests that the use of NOACs on top of DAPT after ACS reduces the rate of recurrent ischaemic events, albeit at the price of increased risk for major bleeding...
May 2018: Interventional Cardiology
https://www.readbyqxmd.com/read/29928314/anticoagulant-therapy-for-acute-coronary-syndromes
#3
REVIEW
Eunice Nc Onwordi, Amr Gamal, Azfar Zaman
Anticoagulation in conjunction with antiplatelet therapy is central to the management of acute coronary syndromes (ACS). When used effectively it is associated with a reduction in recurrent ischaemic events including myocardial infarction and stent thrombosis as well as a reduction in death. Effective ischaemic risk reduction whilst balancing bleeding risk remains a clinical challenge. This article reviews the current available evidence for anticoagulation in ACS and recommendations from the European Society of Cardiology...
May 2018: Interventional Cardiology
https://www.readbyqxmd.com/read/29927947/regional-to-tertiary-inter-hospital-transfer-versus-in-house-percutaneous-coronary-intervention-in-acute-coronary-syndrome
#4
Delara Javat, Clare Heal, Jennifer Banks, Stefan Buchholz, Zhihua Zhang
RATIONALE: To address the inaccessibility of interventional cardiac services in North Queensland a new cardiac catheterisation laboratory (CCL) was established in Mackay Base Hospital (MBH) in February 2014. OBJECTIVE: To determine whether the provision of in-house angiography and/or percutaneous coronary intervention (PCI) 1) minimises treatment delays 2) further reduces the risk of mortality, recurrent myocardial infarction (MI) and recurrent ischaemia 3) improves patient satisfaction and 4) minimises cost expenditure compared with inter-hospital transfer for patients with acute coronary syndrome (ACS)...
2018: PloS One
https://www.readbyqxmd.com/read/29926562/-acute-coronary-syndrome
#5
O Gach, Husseini Z El, P Lancellotti
Acute coronary syndromes represent a major cause of mortality in our country. There is a very wide spectrum of clinical presentation since the actual classification of acute coronary syndromes is based on electrocardiographic presentation, that is to say based on absence or presence of ST segment elevation. When dealing with an acute chest pain, once the probability of acute coronary syndrome is established, the emergency care must follow the scientific guidelines. One of the critical steps is represented by the evaluation of ischaemic and hemorrhagic risk in order to tailor optimally antithrombotic and anticoagulation therapies and revascularization timing...
May 2018: Revue Médicale de Liège
https://www.readbyqxmd.com/read/29925187/-a-meta-analysis-on-the-association-between-genetic-polymorphisms-of-osteoprotegerin-and-cardiovascular-disease
#6
J Y Xin, H L Cong
Objective: To explore the association between genetic polymorphisms of rs2073617T/C (950T/C) and rs2073618G/C(1181G/C) in the osteoprotegerin gene and cardiovascular disease with meta-analysis. Methods: A computer-based search for the study of relationship between genetic polymorphisms of rs2073617T/C and rs2073618G/C in the osteoprotegerin gene and cardiovascular disease were performed in electronic databases including China National Knowledge Infrastructure(CNKI), China Biomedical Literature Database, Wanfang Database, Chinese Journal Full-text Database, Embase, PubMed, and Cochrane Library, supplemented by manual search, from the beginning of library to February 28, 2017...
June 24, 2018: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29924791/-algorithm-of-treatment-policy-for-a-femoral-artery-false-aneurysm
#7
A A Fokin, K A Kireev
The purpose of the study was to elaborate an algorithm of treatment policy for post-puncture false aneurysms of the femoral artery (FAFA). The study was performed on the basis of the clinical material over 2014-2017 at the Regional Vascular Centre whose specialists have since 2017 been using the femoral arterial approach (FAA) only if the radial arteries are inaccessible for puncture or for inserting the endovascular tools and appliances. The obtained findings demonstrated that the number of coronary interventions performed with the use of the femoral arterial approach in patients presenting with acute coronary syndrome decreased from a total of 758 (100...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29924379/survival-benefit-from-recent-changes-in-management-of-men-and-women-with-st-elevation-myocardial-infarction-treated-with-percutaneous-coronary-interventions
#8
Łukasz Zandecki, Marcin Sadowski, Marianna Janion, Jacek Kurzawski, Marek Gierlotka, Lech Poloński, Mariusz Gąsior
BACKGROUND: Nowadays, the majority of patients with myocardial infarction with ST-segment elevation (STEMI) are treated with primary percutaneous coronary interventions (pPCI). In recent years, there have been ongoing improvements in PCI techniques, devices and concomitant pharmacotherapy. However, reports on further mortality reduction among PCI-treated STEMI patients remain inconclusive. The aim of this study was to compare changes in management and mortality in PCI-treated STEMI patients between 2005 and 2011 in a real-life setting...
June 20, 2018: Cardiology Journal
https://www.readbyqxmd.com/read/29923156/clinical-efficacy-of-aspirin-with-identification-of-intimal-morphology-by-optical-coherence-tomography-in-preventing-event-recurrence-in-patients-with-vasospasm-induced-acute-coronary-syndrome
#9
Yonggu Lee, Hwan-Cheol Park, Jinho Shin
Using optical coherence tomography (OCT), we found that there were morphological differences in the coronary intima between patients with vasospasm-induced acute coronary syndrome (VACS) and those with stable variant angina. We investigated whether aspirin use would protect against chest pain recurrence in patients with VACS. A retrospective cohort study was performed. Patients with ST-segment elevation who were confirmed to have VACS by a provocation test were included. OCT was performed at the index event and when chest pain recurred to assess intimal morphology...
June 19, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29922739/kounis-syndrome-due-to-hirudotherapy-leech-therapy-in-emergency-department-a-case-report
#10
Tolga Çakmak, İbrahim Çaltekin, Emre Gökçen, Atakan Savrun, Erdoğan Yaşar
Kounis Syndrome is the development of acute coronary syndrome (ACS) because of allergic reactions; allergens, such as foods, insect venom, iodine contrast agent or drugs can cause this syndrome. Hirudotherapy (leech therapy) is increasingly used as a useful therapeutic option in a variety of medical and surgical procedures, and potential complications related to this therapy include Aeromonas species infections, bleeding, anemia and allergic reactions. Here, we present a patient diagnosed as Type 1 Kounis Syndrome after using hirudotherapy for her knee aches...
June 2018: Turkish Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29922732/prognostic-value-of-plasma-st2-in-patients-with-non-st-segment-elevation-acute-coronary-syndrome
#11
Çağrı Kokkoz, Adnan Bilge, Mehmet Irik, Halil I Dayangaç, Mustafa Hayran, Funda Karbek Akarca, Nimet Bilal Erdem, Musa Çavuş
Objective: The aim of this study is to detect plasma ST2 levels in patients who were admitted to emergency department with chest pain and diagnosed with non st segment elevation myocardial infarction (NSTEMI) and to research the relationship between 28-day mortality and ST2 levels. Methods: The present study was conducted at Emergency Department of Celal Bayar University Hafsa Sultan Hospital between September 2015 and January 2016 as a prospective, single-center, cross-sectional study...
June 2018: Turkish Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29922729/the-heart-score-a-guide-to-its-application-in-the-emergency-department
#12
REVIEW
William Brady, Katya de Souza
Chest pain is one of the most common, potentially serious presenting complaints for adult emergency department (ED) visits. The challenge of acute coronary syndrome (ACS) identification with appropriate disposition is quite significant. Many of these patients are low risk and can be managed non-urgently in the outpatient environment; other patients, however, are intermediate to high risk for ACS and should be managed more aggressively, likely with inpatient admission and cardiology consultation. The HEART score, a recently derived clinical decision rule aimed at the identification of risk in the undifferentiated chest pain patient, is potentially quite useful as an adjunct to physician medical decision-making...
June 2018: Turkish Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29922097/acute-myocardial-infarction-in-young-women-current-perspectives
#13
REVIEW
Jaya Chandrasekhar, Amrita Gill, Roxana Mehran
Acute myocardial infarction (AMI) is the leading cause of death in women worldwide. Every year, in the USA alone, more than 30,000 young women <55 years of age are hospitalized with AMI. In recent decades, the incidence of AMI is increasing in younger women in the context of increasing metabolic syndrome, diabetes mellitus, and non-traditional risk factors such as stress, anxiety, and depression. Although women are classically considered to present with atypical chest pain, several observational data confirm that men and women experience similar rates of chest pain, with some differences in intensity, duration, radiation, and the choice of descriptors...
2018: International Journal of Women's Health
https://www.readbyqxmd.com/read/29922047/relationship-between-high-sensitivity-cardiac-troponin-t-and-the-prognosis-of-elderly-inpatients-with-non-acute-coronary-syndromes
#14
Wei Wu, Dong-Xia Li, Qing Wang, Ying Xu, Yun-Jing Cui
Objective: Low-level high-sensitivity cardiac troponin T (hs-cTnT) increases in elderly population. In this study, the relationship between hs-cTnT level and all-cause death of elderly inpatients with non-acute coronary syndrome (non-ACS) after discharge from the hospital was investigated. Materials and methods: Non-ACS patients aged >65 years admitted in the General Practice Wards and Department of Geriatrics of Fuxing Hospital Affiliated to Capital Medical University were enrolled in the study...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29922008/long-term-outcome-of-coronary-artery-dilatation-in-kawasaki-disease
#15
Najib Advani, Sudigdo Sastroasmoro, Teddy Ontoseno, Cuno Spm Uiterwaal
Background: Kawasaki disease (KD) is an acute systemic vasculitis syndrome with a high incidence of coronary aneurysms in untreated children. The majority of aneurysms resulting from KD are known to regress with time. Aims: This study aimed to determine the course and outcome of coronary artery dilatation in patients with KD and ascertain whether there are any differences in the outcomes in the different branches. Setting and Design: This is a retrospective cohort study of patients diagnosed with KD with midterm follow-up data...
May 2018: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/29921621/outcomes-of-beta-blocker-use-in-cocaine-associated-chest-pain-a-meta-analysis
#16
Don Pham, Daniel Addison, Waleed Kayani, Arunima Misra, Hani Jneid, Jon Resar, Nassir Lakkis, Mahboob Alam
OBJECTIVES: Beta blockers (β-blockers) remain a standard therapy in the early treatment of acute coronary syndromes. However, β-blocker therapy in patients with cocaine-associated chest pain (CACP) continues to be an area of debate due to the potential risk of unopposed α-adrenergic stimulation and coronary vasospasm. Therefore, we performed a systematic review and meta-analysis of available studies to compare outcomes of β-blocker versus no β-blocker use among patients with CACP...
June 19, 2018: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29921477/quality-of-evidence-based-guidelines-for-transfusion-of-red-blood-cells-and-plasma-a-systematic-review
#17
REVIEW
Katerina Pavenski, Simon Stanworth, Mark Fung, Erica M Wood, Joanne Pink, Michael F Murphy, Heather Hume, Susan Nahirniak, Kathryn E Webert, Susano Tanael, Denise Landry, Nadine Shehata
Many transfusion guidelines are available, but little appraisal of their quality has been undertaken. The quality of guidelines may potentially influence adoption. Our aim was to determine the quality of evidence-based transfusion guidelines (EBG) for red cells and plasma, using the Appraisal of Guidelines for Research and Evaluation (AGREE II) instrument, and assess duplication and consistency of recommendations. MEDLINE and EMBASE were systematically searched for EBG from 2005 to June 3, 2016. Citations were reviewed for inclusion in duplicate...
June 1, 2018: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/29915959/the-utility-of-total-lipid-core-burden-index-maximal-lipid-core-burden-index-ratio-within-the-culprit-plaque-to-predict-filter-no-reflow-insight-from-near-infrared-spectroscopy-with-intravascular-ultrasound
#18
Takao Sato, Yoshifusa Aizawa, Naomasa Suzuki, Yuji Taya, Sho Yuasa, Shohei Kishi, Tomoyasu Koshikawa, Koichi Fuse, Satoshi Fujita, Yoshio Ikeda, Hitoshi Kitazawa, Minoru Takahashi, Masaaki Okabe
Filter-no reflow (FNR) is a phenomenon wherein flow improves after the retrieve of distal protection. Near-infrared spectroscopy with intravascular ultrasound (NIRS-IVUS) enables lipid detection. We evaluated the predictors of FNR during PCI using NIRS-IVUS. Thirty-two patients who underwent PCI using the Filtrap® for acute coronary syndrome (ACS) were enrolled. The culprit plaque (CP) was observed using NIRS-IVUS. Total lipid-core burden index (T-LCBI) and maximal LCBI over any 4-mm segment (max-LCBI4mm) within CP were evaluated...
June 18, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29915905/antithromboembolic-strategies-for-patients-with-atrial-fibrillation-undergoing-percutaneous-coronary-intervention
#19
REVIEW
Ayesha Ather, Benjamin Laliberte, Brent N Reed, Ashley Schenk, Kristin Watson, Sandeep Devabhakthuni, Vincent Y See
We set out to synthesize available data on antithrombotic strategies for patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI), with a focus on triple antithrombotic therapy (triple therapy [TT]; dual antiplatelet therapy plus an anticoagulant) versus dual therapy (DT; one antiplatelet agent and an anticoagulant). We searched OVID MEDLINE and PubMed from January 2005 to September 2017 using the search terms oral anticoagulant, triple therapy, dual therapy, acute coronary syndrome, percutaneous coronary intervention, and atrial fibrillation (limited to randomized controlled trials, observational studies, English language, minimum 6-12 months of follow-up, minimum 100 human patients)...
June 19, 2018: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/29915535/the-therapeutic-efficacy-of-danhong-injection-combined-with-percutaneous-coronary-intervention-in-acute-coronary-syndrome-a-systematic-review-and-meta-analysis
#20
REVIEW
Jun-Bo Zou, Xiao-Fei Zhang, Jing Wang, Fang Wang, Jiang-Xue Cheng, Fang-Yan Yang, Xiao Song, Yu Wang, Yu-Lin Liang, Ya-Jun Shi
Background: Percutaneous coronary intervention (PCI) is widely used in treatment of acute coronary syndrome (ACS) clinically. It is believed that Danhong injection (DHI) extracted from salviae miltiorrhizae and flos carthami combined with PCI could increase the therapeutic efficacy on ACS. We provide an updated meta-analysis with detailed information on combination of DHI and PCI therapy. Materials and Methods: Electronic databases were searched for appropriate articles without language limitations on key words before October 22, 2017...
2018: Frontiers in Pharmacology
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