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Acute coronary syndrome

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https://www.readbyqxmd.com/read/30242056/associations-between-circulating-igg-antibodies-to-apolipoprotein-b-100-derived-peptide-antigens-and-acute-coronary-syndrome-in-a-chinese-han-population
#1
Weina Hu, Xueying Zhang, Yunan Han, Yong Wang, Mingming Lei, Ian L Megson, Jun Wei, Yuanzhe Jin
Acute coronary syndrome (ACS) is the major cause of mortality worldwide and caused mainly by atherosclerosis of coronary arteries. Apolipoprotein B100 (ApoB100) is a major component of low-density lipoprotein (LDL) and its oxidation can trigger inflammation in vascular endothelial cells leading to atherosclerosis. The present study developed an enzyme-linked immunosorbent assay (ELISA) in-house with ApoB100-derived peptide antigens to circulating anti-ApoB100 IgG antibodies in patients with ACS. Fifteen ApoB100-derived peptide antigens (Ag1-Ag15) were designed to develop an in-house ELISA for detection of circulating anti-ApoB100 IgG levels in 350 patients with ACS and 201 control subjects among a Chinese population...
September 21, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/30241493/epidemiology-of-non-steroidal-anti-inflammatory-drugs-consumption-in-spain-the-mcc-spain-study
#2
Inés Gómez-Acebo, Trinidad Dierssen-Sotos, María de Pedro, Beatriz Pérez-Gómez, Gemma Castaño-Vinyals, Tania Fernández-Villa, Camilo Palazuelos-Calderón, Pilar Amiano, Jaione Etxeberria, Yolanda Benavente, Guillermo Fernández-Tardón, Inmaculada Salcedo-Bellido, Rocío Capelo, Rosana Peiró, Rafael Marcos-Gragera, José M Huerta, Adonina Tardón, Aurelio Barricarte, Jone-Miren Altzibar, Jessica Alonso-Molero, Verónica Dávila-Batista, Nuria Aragonés, Marina Pollán, Manolis Kogevinas, Javier Llorca
BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used despite their risk of gastrointestinal bleeding or cardiovascular events. We report the profile of people taking NSAIDs in Spain, and we include demographic factors, health-related behaviours and cardiovascular disease history. METHODS: Four thousand sixtyparticipants were selected using a pseudorandom number list from Family Practice lists in 12 Spanish provinces. They completed a face-to-face computerized interview on their NSAID consumption, demographic characteristics, body mass index, alcohol and tobacco consumption and medical history...
September 21, 2018: BMC Public Health
https://www.readbyqxmd.com/read/30239711/modes-and-timing-of-death-in-66-252-patients-with-non-st-segment-elevation-acute-coronary-syndromes-enrolled-in-14-timi-trials
#3
David D Berg, Stephen D Wiviott, Eugene Braunwald, Jianping Guo, KyungAh Im, Amir Kashani, C Michael Gibson, Christopher P Cannon, David A Morrow, Deepak L Bhatt, Jessica L Mega, Michelle L O'Donoghue, Elliott M Antman, L Kristin Newby, Marc S Sabatine, Robert P Giugliano
Aims: Although presenting features and early sequelae of non-ST-segment elevation acute coronary syndromes (NSTE-ACS) are well described, less is known about longer-term risks and modes of death. The purpose of this study was to characterize modes of death following NSTE-ACS in clinical trial populations. Methods and results: We evaluated 66 252 patients with NSTE-ACS enrolled in 14 Thrombolysis in Myocardial Infarction (TIMI) trials, examining baseline characteristics and modes and timing of death...
September 20, 2018: European Heart Journal
https://www.readbyqxmd.com/read/30238704/de-escalation-of-p2y12-receptor-inhibitor-therapy-after-acute-coronary-syndromes-in-patients-undergoing-percutaneous-coronary-intervention
#4
REVIEW
Danny Kupka, Dirk Sibbing
Dual antiplatelet therapy (DAPT) - a combination of a P2Y₁₂ receptor inhibitor and aspirin - has revolutionized antithrombotic treatment. Potent P2Y₁₂ inhibitors such as prasugrel and ticagrelor exhibit a strong and more consistent platelet inhibition when compared to clopidogrel. Therefore, ticagrelor and prasugrel significantly reduce ischemic events, but at an expense of an increased bleeding risk in acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI). These observations have engaged intensive clinical research in alternative DAPT regimens to achieve sufficient platelet inhibition with an acceptable bleeding risk...
October 2018: Korean Circulation Journal
https://www.readbyqxmd.com/read/30238210/beta-blocker-therapy-in-acute-coronary-syndromes-a-time-trend-interpretation-of-evolving-clinical-benefits-editorial-to-the-use-of-oral-beta-blockers-and-clinical-outcomes-in-patients-with-non-st-segment-elevation-acute-coronary-syndromes-a-long-term-follow
#5
EDITORIAL
https://www.readbyqxmd.com/read/30237949/mid-ventricle-takotsubo-in-a-patient-with-goodpasture-syndrome
#6
Gerardo Zablah, Raúl A Montañez-Valverde, David Hurtado-de-Mendoza, Rosario Colombo
Takotsubo syndrome (TTS) is characterized by transient, regional systolic dysfunction of the left ventricle, often mimicking acute coronary syndrome. Atypical variants of this syndrome with mid-ventricular, basal, and focal wall motion patterns are increasingly diagnosed and show different clinical features compared to typical TTS. Even though TTS was generally considered a benign condition, continuous and strict monitoring is necessary to diagnose potentially life-threating complications. This is the first case report, to our knowledge, of atypical TTS in a patient with Goodpasture syndrome triggered by acute kidney injury (AKI)...
July 17, 2018: Curēus
https://www.readbyqxmd.com/read/30237934/what-s-the-risk-older-women-report-fewer-symptoms-for-suspected-acute-coronary-syndrome-than-younger-women
#7
Holli A DeVon, Karen Vuckovic, Larisa A Burke, Sahereh Mirzaei, Katherine Breen, Nadia Robinson, Jessica Zegre-Hemsey
The purpose of the study was to determine whether older (≥65 years) and younger (<65 years) women presenting to the emergency department (ED) with symptoms suggestive of acute coronary syndrome (ACS) varied on risk factors, comorbid conditions, functional status, and symptoms that have implications for emergent cardiac care. Women admitted to five EDs were enrolled. The ACS Symptom Checklist was used to measure symptoms. Comorbid conditions and functional status were measured with the Charlson Comorbidity Index and Duke Activity Status Index...
2018: BioResearch Open Access
https://www.readbyqxmd.com/read/30236499/psoriatic-disease-aging-chronic-inflammation-and-acute-coronary-syndromes-two-and-two-may-not-always-make-four
#8
EDITORIAL
Angelo A Manfredi, Patrizia Rovere-Querini
No abstract text is available yet for this article.
September 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/30236360/temporal-trends-and-outcomes-of-percutaneous-coronary-interventions-in-nonagenarians-a-national-perspective
#9
Kashish Goel, Tanush Gupta, Rajiv Gulati, Malcolm R Bell, Dhaval Kolte, Sahil Khera, Deepak L Bhatt, Charanjit S Rihal, David R Holmes
OBJECTIVES: This study sought to assess temporal trends and outcomes of percutaneous coronary intervention (PCI) in nonagenarians. BACKGROUND: With increasing life expectancy, nonagenarians requiring PCI are increasing even though outcomes data are limited. METHODS: The National Inpatient Sample was used to identify all hospitalizations for PCI in patients aged ≥90 years from January 1, 2003, to December 31, 2014. The primary outcome was in-hospital mortality...
September 24, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/30236352/a-practical-approach-to-the-management-of-complications-during-percutaneous-coronary-intervention
#10
REVIEW
Francesco Giannini, Luciano Candilio, Satoru Mitomo, Neil Ruparelia, Alaide Chieffo, Luca Baldetti, Francesco Ponticelli, Azeem Latib, Antonio Colombo
Percutaneous coronary intervention relieves symptoms in patients with chronic ischemic heart disease resistant to optimal medical therapy and alters the natural history of acute coronary syndromes. However, adverse procedural outcomes may occur during the intervention. Knowledge of possible complications and their timely management are essential for the practicing cardiologist and can be life-saving for the patient. In this review, the authors summarize potential complications of percutaneous coronary intervention focusing on their practical management...
September 24, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/30236312/alterations-of-hyaluronan-metabolism-in-acute-coronary-syndrome-implications-for-plaque-erosion
#11
Daniela Pedicino, Ramona Vinci, Ada F Giglio, Eugenia Pisano, Italo Porto, Rocco Vergallo, Giulio Russo, Aureliano Ruggio, Alessia D'Aiello, Davide Flego, Gianmarco Annibali, Francesco Trotta, Roberto Piacentini, Giampaolo Niccoli, Giovanna Liuzzo, Filippo Crea
BACKGROUND: Superficial erosion currently causes at least one-third of acute coronary syndromes (ACS), and its incidence is increasing. Yet, the underlying mechanisms in humans are still largely unknown. OBJECTIVES: The authors sought to assess the role of hyaluronan (HA) metabolism in ACS. METHODS: Peripheral blood mononuclear cells were collected from ACS (n = 66), stable angina (SA) (n = 55), and control (CTRL) patients (n = 45). The authors evaluated: 1) gene expression of hyaluronidase 2 (HYAL2) (enzyme degrading high-molecular-weight HA to its proinflammatory 20-kDa isoform) and of CD44v1, CD44v4, and CD44v6 splicing variants of HA receptor; and 2) HYAL2 and CD44 protein expression...
September 25, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/30235969/long-term-outcome-of-first-300-implanted-absorb-bioresorbable-vascular-scaffolds-in-an-all-comers-middle-east-population
#12
Arif Al Nooryani, Wael N Elabbassi, Bassam AlBaba, Jalal A Kerfes, Loai M Abudaqa, Amit Bhatia, Nagwa A Abdelrahman, Nikola Boskovic, Branko Beleslin
Objectives To evaluate long-term clinical outcomes of the Absorb bioresorbable vascular scaffold (BVS) system (Abbott Vascular) in an all-comers Middle East population. Methods This prospective registry study included an initial set of patients with coronary lesions treated using Absorb BVS. Patients were followed for target vessel failure (TVF) including cardiac death, target vessel myocardial infarction (MI), and target lesion revascularization. Results A total of 217 patients (age, 55 ± 11 years; male, 169) with 300 treated lesions were included (median follow-up, 36 months [range, 26-41 months]; complete follow-up, 201 patients)...
September 21, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/30235475/meta-analysis-of-potent-p2y12-adp-receptor-antagonist-therapy-compared-to-clopidogrel-therapy-in-acute-coronary-syndrome-patients-with-chronic-kidney-disease
#13
Laurent Bonello, Marc Laine, Gilles Lemesle, Etienne Puymirat, Thibaut Dabry, Franck Thuny, Franck Paganelli, Daniel Aradi, Corinne Frere, Stéphane Burtey, Dirk Sibbing, Julien Mancini
BACKGROUND:  The clinical benefit of anti-platelet agents in patients with chronic kidney disease (CKD) is uncertain. In addition, the risk-benefit ratio of potent oral P2Y12-adenosine diphosphate (ADP) receptor antagonists (PPAs), namely, prasugrel and ticagrelor, compared with clopidogrel in CKD patients suffering from acute coronary syndrome (ACS) remains unknown. OBJECTIVE:  We performed a meta-analysis of all studies comparing the clinical outcomes of PPA and clopidogrel therapy in CKD patients suffering from ACS...
September 20, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/30234907/association-between-mild-thyroid-dysfunction-and-clinical-outcome-in-acute-coronary-syndrome-undergoing-percutaneous-coronary-intervention
#14
Qian Cao, Yundi Jiao, Tongtong Yu, Zhaoqing Sun
BACKGROUND: Thyroid hormones profoundly influence the cardiovascular system, but the effects of mild thyroid dysfunction on the clinical outcome of acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI) are not well defined. This study aimed to determine the effect of mild thyroid dysfunction on 12-month prognosis in ACS patients undergoing PCI. METHODS: In this prospective cohort study with a 12-month follow-up, 1560 individuals were divided into four groups based on thyroid hormone levels upon admission: euthyroidism (used as a reference group), subclinical hypothyroidism, subclinical hyperthyroidism, and low triiodothyronine syndrome (low T3 syndrome)...
September 20, 2018: Cardiology Journal
https://www.readbyqxmd.com/read/30234899/cardiac-sarcoidosis-and-ventricular-arrhythmias-a-rare-association-of-a-rare-disease-a-retrospective-cohort-study-from-the-national-inpatient-sample-and-current-evidence-for-management
#15
Amr Salama, Abdullah Abdullah, Abdul Wahab, George Eigbire, Ryan Hoefen, Richard Alweis
BACKGROUND: Sarcoidosis is an increasingly recognized multi-systemic condition. Cardiac sarcoidosis is associated with ventricular arrhythmias and higher mortality rates. Little epidemiological data is available regarding the disease and associated ventricular arrhythmias. METHODS: Data from the National Inpatient Sample (NIS) database 2012-2014, were reviewed. Discharges associated with sarcoidosis were identified as the target population using relevant ICD-9-CM codes...
September 20, 2018: Cardiology Journal
https://www.readbyqxmd.com/read/30234895/lipoprotein-a-screening-in-young-and-middle-aged-patients-presenting-with-acute-coronary-syndrome
#16
Ayman Jubran, Anna Zetser, Barak Zafrir
BACKGROUND: Elevated lipoprotein(a) [Lp(a)] is an independent risk factor for coronary artery disease (CAD). However, its role in real-world practice and implications for clinical care remains limited. Under investigation herein, are the clinical characteristics associated with increased Lp(a) levels in patients presenting with acute coronary syndrome (ACS). METHODS: Lp(a) was measured at admission in patients ≤ 65 years of age presenting with ACS in a single center...
September 20, 2018: Cardiology Journal
https://www.readbyqxmd.com/read/30234682/left-main-coronary-artery-external-compression-by-lung-adenocarcinoma-successfully-treated-with-percutaneous-coronary-intervention
#17
Marco Ferlini, Roberto Dore, Gianmarco Iannopollo, Gaetano M De Ferrari, Luigi Oltrona Visconti
: A 54-year-old woman with a history of stage IV nonsmall-cell lung cancer, on treatment with chemiotherapy was hospitalized for acute coronary syndrome. Coronary angiography showed a tight stenosis of ostial left main coronary artery (LMCA) probably caused by external compression. Computed tomography scan confirmed LMCA compression and entrapment between a neoplastic mass and the root of the aorta, with vessel collapsing during diastole but patency and narrowing in systole. A drug-eluting stent was then successfully implanted at LMCA ostium without further episodes of angina...
September 17, 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/30233897/an-atypical-presentation-of-acute-coronary-syndrome
#18
Amir Solomonica, Shahar Lavi, Tawfiq Choudhury, Rodrigo Bagur
No abstract text is available yet for this article.
August 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/30233785/oxidant-and-antioxidant-status-in-coronary-artery-disease
#19
Abdolhossein Bastani, Sadegh Rajabi, Afshin Daliran, Habibollah Saadat, Feridoun Karimi-Busheri
Formation of atherosclerotic plaques is the major cause of coronary artery disease (CAD). Several lines of study have revealed the role of oxidative stress in CAD pathogenesis. In the present study the aim was to investigate the oxidative and antioxidative markers in CAD patients and a control population. The study sample comprised of acute coronary syndrome (ACS) patients, chronic CAD patients and healthy controls (n=30/group). Blood samples of patients and control subjects were collected to measure the concentrations of reduced glutathione (GSH), malondialdehyde (MDA) and the percentage of MDA release as well as the activity of erythrocyte glutathione peroxidase (GPx) and total antioxidant capacity (TAC) of plasma...
October 2018: Biomedical Reports
https://www.readbyqxmd.com/read/30233677/long-noncoding-rna-tcons_00024652-regulates-vascular-endothelial-cell-proliferation-and-angiogenesis-via-microrna-21
#20
Muertiza Halimulati, Bagedati Duman, Julaiti Nijiati, Abudoureyimu Aizezi
Acute coronary syndrome caused by the rupture of atherosclerotic plaques is one of the primary causes of major cardiovascular events, and neovascularization within the plaque is closely associated with its stability. Long noncoding RNA (lncRNAs) is a type of noncoding RNA that serves a crucial role in regulating vascular endothelial cells (VECs). The aim of the present study was to investigate the effect of lncRNA TCONS_00024652 on the proliferation and angiogenesis of VECs following stimulation with TNF-α...
October 2018: Experimental and Therapeutic Medicine
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