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JOURNAL ARTICLE
Sarah E Rowan, Jason Haukoos, Kevin F Kamis, Emily Hopkins, Stephanie Gravitz, Carolynn Lyle, Alia A Al-Tayyib, Edward M Gardner, James W Galbraith, Yu-Hsiang Hsieh, Michael S Lyons, Richard E Rothman, Douglas A E White, Jake R Morgan, Benjamin P Linas, Allison L Sabel, David L Wyles
BACKGROUND: Hepatitis C (HCV) poses a major public health problem in the USA. While early identification is a critical priority, subsequent linkage to a treatment specialist is a crucial step that bridges diagnosed patients to treatment, cure, and prevention of ongoing transmission. Emergency departments (EDs) serve as an important clinical setting for HCV screening, although optimal methods of linkage-to-care for HCV-diagnosed individuals remain unknown. In this article, we describe the rationale and design of The Determining Effective Testing in Emergency Departments and Care Coordination on Treatment Outcomes (DETECT) for Hepatitis C (Hep C) Linkage-to-Care Trial...
January 27, 2023: Trials
#22
JOURNAL ARTICLE
Ariel M Hay, Travis Nemkov, Fabia Gamboni, Monika Dzieciatkowska, Alicia Key, Matthew Galbraith, Kyle Bartsch, Kaiqi Sun, Yang Xia, Mars Stone, Michael P Busch, Philip J Norris, James C Zimring, Angelo D'Alessandro
Blood storage promotes the rapid depletion of red blood cell (RBC) high-energy adenosine triphosphate and 2,3-diphosphoglycerate, which are critical regulators of erythrocyte physiology and function, as well as oxygen kinetics and post transfusion survival. Sphingosine 1-phosphate (S1P) promotes fluxes through glycolysis. We hypothesized that S1P supplementation to stored RBC units would improve energy metabolism and post-transfusion recovery. We quantified S1P in 1,929 samples (n=643, storage day 10, 23, 42) from the REDS RBC Omics study...
December 5, 2022: Blood Advances
#23
JOURNAL ARTICLE
James D Galbraith, Atma M Ivancevic, Zhipeng Qu, David L Adelson
Transposable elements (TEs) are prevalent genomic components which can replicate as a function of mobilization in eukaryotes. Not only do they alter genome structure, they also play regulatory functions or organize chromatin structure. In addition to vertical parent-to-offspring inheritance, TEs can also horizontally "jump" between species, known as horizontal transposon transfer (HTT). This can rapidly alter the course of genome evolution. In this chapter, we provide a practical framework to detect HTT events...
2023: Methods in Molecular Biology
#24
JOURNAL ARTICLE
Glen James Henson, Bruce V Taylor, Ingrid van der Mei, Suzi B Claflin, Steve Simpson-Yap, Andrew J Palmer, Qing Xia, Benny Antony, Ambrish Singh, Julie A Campbell
INTRODUCTION: Generic multiattribute utility instruments (MAUIs) are efficient tools for determining and enumerating health-related quality of life. MAUIs accomplish this by generating health state utilities (HSUs) via algorithms. Minimal important differences (MIDs) assist with the interpretation of HSUs by estimating minimum changes that are clinically significant. The overall goal of the proposed systematic review and meta-analysis is the development of comprehensive guidelines for MID estimation...
October 25, 2022: BMJ Open
#25
JOURNAL ARTICLE
Jason S Haukoos, Sarah E Rowan, James W Galbraith, Richard E Rothman, Yu-Hsiang Hsieh, Emily Hopkins, Rachel A Houk, Matthew F Toerper, Kevin F Kamis, Jake R Morgan, Benjamin P Linas, Alia A Al-Tayyib, Edward M Gardner, Michael S Lyons, Allison L Sabel, Douglas A E White, David L Wyles
BACKGROUND: Early identification of HCV is a critical health priority, especially now that treatment options are available to limit further transmission and provide cure before long-term sequelae develop. Emergency departments (EDs) are important clinical settings for HCV screening given that EDs serve many at-risk patients who do not access other forms of healthcare. In this article, we describe the rationale and design of The Determining Effective Testing in Emergency Departments and Care Coordination on Treatment Outcomes (DETECT) for Hepatitis C (Hep C) Screening Trial...
April 25, 2022: Trials
#26
JOURNAL ARTICLE
Adam Nunn, Isaac Rodríguez-Arévalo, Zenith Tandukar, Katherine Frels, Adrián Contreras-Garrido, Pablo Carbonell-Bejerano, Panpan Zhang, Daniela Ramos-Cruz, Katharina Jandrasits, Christa Lanz, Anthony Brusa, Marie Mirouze, Kevin Dorn, David Galbraith, Brice A Jarvis, John C Sedbrook, Donald L Wyse, Christian Otto, David Langenberger, Peter F Stadler, Detlef Weigel, M David Marks, James A Anderson, Claude Becker, Ratan Chopra
Thlaspi arvense (field pennycress) is being domesticated as a winter annual oilseed crop capable of improving ecosystems and intensifying agricultural productivity without increasing land use. It is a selfing diploid with a short life cycle and is amenable to genetic manipulations, making it an accessible field-based model species for genetics and epigenetics. The availability of a high-quality reference genome is vital for understanding pennycress physiology and for clarifying its evolutionary history within the Brassicaceae...
January 6, 2022: Plant Biotechnology Journal
#27
JOURNAL ARTICLE
James D Galbraith, Robert Daniel Kortschak, Alexander Suh, David L Adelson
Since the sequencing of the zebra finch genome it has become clear that avian genomes, while largely stable in terms of chromosome number and gene synteny, are more dynamic at an intrachromosomal level. A multitude of intrachromosomal rearrangements and significant variation in transposable element (TE) content have been noted across the avian tree. TEs are a source of genome plasticity, because their high similarity enables chromosomal rearrangements through nonallelic homologous recombination, and they have potential for exaptation as regulatory and coding sequences...
December 1, 2021: Genome Biology and Evolution
#28
JOURNAL ARTICLE
James D Galbraith, Alastair J Ludington, Kate L Sanders, Alexander Suh, David L Adelson
Transposable elements (TEs) are self-replicating genetic sequences and are often described as important 'drivers of evolution'. This driving force is because TEs promote genomic novelty by enabling rearrangement, and through exaptation as coding and regulatory elements. However, most TE insertions potentially lead to neutral or harmful outcomes, therefore host genomes have evolved machinery to suppress TE expansion. Through horizontal transposon transfer (HTT) TEs can colonize new genomes, and since new hosts may not be able to regulate subsequent replication, these TEs may proliferate rapidly...
September 2021: Biology Letters
#29
JOURNAL ARTICLE
J Daniel Moore, James Galbraith, Roger Humphries, Jennifer R Havens
Background: We describe the initial results of an adult academic emergency department (ED) nontargeted hepatitis C virus (HCV) screening program serving Appalachia, which is disproportionately affected by the opioid epidemic. Methods: The study was a retrospective screening study of ED systematic, nontargeted, opt-out HCV testing outcomes from July 2018 through September 2020. Eligibility requirements for "nontargeted" HCV testing included age ≥18 years, verbally able to communicate, receiving bloodwork already as part of routine clinical care, and not opting out of testing...
August 2021: Open Forum Infectious Diseases
#30
JOURNAL ARTICLE
Keith T Flaherty, James H Doroshow, Susan Galbraith, Antoni Ribas, Paul G Kluetz, Richard Pazdur, Marc R Theoret
<b/> The COVID-19 pandemic brought about major changes in cancer clinical trials. In its aftermath, the community has an opportunity to incorporate some of these changes as part of the future of trial conduct to make it more patient centered.
July 21, 2021: Cancer Discovery
#31
REVIEW
Elizabeth Olson, Kanupriya Gupta, Barbara Van Der Pol, James W Galbraith, William M Geisler
Mycoplasma genitalium (MG) infection, a sexually transmitted infection (STI), causes cervicitis and may cause reproductive sequelae and adverse pregnancy outcomes. Some MG-infected women report dysuria, a symptom frequently attributed to urinary tract infection (UTI). Given potential MG-associated morbidity and the likelihood that UTI treatment would be ineffective in eradicating MG, an improved understanding of MG infection frequency and clinical significance in young women reporting dysuria is needed. We conducted MG testing on stored urogenital specimens collected in a pilot study on frequency of STIs in young women presenting to an emergency department for dysuria evaluation and performed a literature review on MG infection frequency in women reporting dysuria...
November 2021: International Journal of STD & AIDS
#32
JOURNAL ARTICLE
Kanupriya Gupta, Sally A Harrison, Nkele A Davis, Matilda L Culp, Samuel C Hand, Tina Simpson, Barbara Van Der Pol, James W Galbraith, Nicholas J Van Wagoner, Sandra G Morrison, Richard P Morrison, William M Geisler
BACKGROUND: Chlamydia trachomatis (CT) infection remains highly prevalent and young women are disproportionately affected. Most CT-infected women are asymptomatic and their infection often goes unrecognized and untreated. We hypothesized that testing for active CT infection with molecular diagnostics and obtaining a reported history of CT infection underestimates the prevalence of current and past CT infection, and incorporating serum CT antibody testing in addition to these other prevalence measures would generate more accurate estimates of the prevalence of CT infection in asymptomatic young women...
January 12, 2021: Sexually Transmitted Diseases
#33
JOURNAL ARTICLE
Eilidh Bruce, Ben Carter, Terence J Quinn, Alessia Verduri, Oliver Pearson, Arturo Vilches-Moraga, Angeline Price, Aine McGovern, Louis Evans, Kathryn McCarthy, Jonathan Hewitt, Susan Moug, Phyo K Myint, Behalf Of Cope Study Team, Alice Einarsson, Anna Fleck, Carly Bisset, Ross Alexander, Giovanni Guaraldi, Caroline Murphy, Joanna Kelly, Roxanna Short, Philip Braude, Tarik El Jichi Mutasem, Sandeep Singh, Dolcie Paxton, Will Harris, James Hesford, Mark Holloway, Emma Mitchell, Frances Rickard, Norman Galbraith, Emma Bhatti, Jenny Edwards, Siobhan Duffy, Fenella Barlow-Pay, Lyndsey Pearce, Madeline Garcia, Shefali Sangani, Thomas Kneen, Thomas Lee, Charlotte Davey, Sheila Jones, Kiah Lunstone, Alice Cavenagh, Charlotte Silver, Thomas Telford, Rebecca Simmons, Michael Stechman
BACKGROUND: In response to the COVID-19 pandemic, many countries mandated staying at home to reduce transmission. This study examined the association between living arrangements (house occupancy numbers) and outcomes in COVID-19. METHODS: Study population was drawn from the COPE Study, a multicentre cohort study. House occupancy was defined as: living alone; living with one other person; living with multiple other people; or living in a nursing/residential home...
May 17, 2021: European Journal of Public Health
#34
JOURNAL ARTICLE
Frederick C Draper, Flavia R C Costa, Gabriel Arellano, Oliver L Phillips, Alvaro Duque, Manuel J Macía, Hans Ter Steege, Gregory P Asner, Erika Berenguer, Juliana Schietti, Jacob B Socolar, Fernanda Coelho de Souza, Kyle G Dexter, Peter M Jørgensen, J Sebastian Tello, William E Magnusson, Timothy R Baker, Carolina V Castilho, Abel Monteagudo-Mendoza, Paul V A Fine, Kalle Ruokolainen, Euridice N Honorio Coronado, Gerardo Aymard, Nállarett Dávila, Mauricio Sánchez Sáenz, Marcos A Rios Paredes, Julien Engel, Claire Fortunel, C E Timothy Paine, Jean-Yves Goret, Aurelie Dourdain, Pascal Petronelli, Elodie Allie, Juan E Guevara Andino, Roel J W Brienen, Leslie Cayola Pérez, Ângelo G Manzatto, Narel Y Paniagua Zambrana, Jean-François Molino, Daniel Sabatier, Jerôme Chave, Sophie Fauset, Roosevelt Garcia Villacorta, Maxime Réjou-Méchain, Paul E Berry, Karina Melgaço, Ted R Feldpausch, Elvis Valderamma Sandoval, Rodolfo Vasquez Martinez, Italo Mesones, André B Junqueira, Katherine H Roucoux, José J de Toledo, Ana C Andrade, José Luís Camargo, Jhon Del Aguila Pasquel, Flávia D Santana, William F Laurance, Susan G Laurance, Thomas E Lovejoy, James A Comiskey, David R Galbraith, Michelle Kalamandeen, Gilberto E Navarro Aguilar, Jim Vega Arenas, Carlos A Amasifuen Guerra, Manuel Flores, Gerardo Flores Llampazo, Luis A Torres Montenegro, Ricardo Zarate Gomez, Marcelo P Pansonato, Victor Chama Moscoso, Jason Vleminckx, Oscar J Valverde Barrantes, Joost F Duivenvoorden, Sidney Araújo de Sousa, Luzmila Arroyo, Ricardo O Perdiz, Jessica Soares Cravo, Beatriz S Marimon, Ben Hur Marimon Junior, Fernanda Antunes Carvalho, Gabriel Damasco, Mathias Disney, Marcos Salgado Vital, Pablo R Stevenson Diaz, Alberto Vicentini, Henrique Nascimento, Niro Higuchi, Tinde Van Andel, Yadvinder Malhi, Sabina Cerruto Ribeiro, John W Terborgh, Raquel S Thomas, Francisco Dallmeier, Adriana Prieto, Renato R Hilário, Rafael P Salomão, Richarlly da Costa Silva, Luisa F Casas, Ima C Guimarães Vieira, Alejandro Araujo-Murakami, Fredy Ramirez Arevalo, Hirma Ramírez-Angulo, Emilio Vilanova Torre, Maria C Peñuela, Timothy J Killeen, Guido Pardo, Eliana Jimenez-Rojas, Wenderson Castro, Darcy Galiano Cabrera, John Pipoly, Thaiane Rodrigues de Sousa, Marcos Silvera, Vincent Vos, David Neill, Percy Núñez Vargas, Dilys M Vela, Luiz E O C Aragão, Ricardo Keichi Umetsu, Rodrigo Sierra, Ophelia Wang, Kenneth R Young, Nayane C C S Prestes, Klécia G Massi, José Reyna Huaymacari, Germaine A Parada Gutierrez, Ana M Aldana, Miguel N Alexiades, Fabrício Baccaro, Carlos Céron, Adriane Esquivel Muelbert, Julio M Grandez Rios, Antonio S Lima, Jonathan L Lloyd, Nigel C A Pitman, Luis Valenzuela Gamarra, Cesar J Cordova Oroche, Alfredo F Fuentes, Walter Palacios, Sandra Patiño, Armando Torres-Lezama, Christopher Baraloto
The forests of Amazonia are among the most biodiverse plant communities on Earth. Given the immediate threats posed by climate and land-use change, an improved understanding of how this extraordinary biodiversity is spatially organized is urgently required to develop effective conservation strategies. Most Amazonian tree species are extremely rare but a few are common across the region. Indeed, just 227 'hyperdominant' species account for >50% of all individuals >10 cm diameter at 1.3 m in height...
June 2021: Nature Ecology & Evolution
#35
JOURNAL ARTICLE
L Alexander Liggett, Matthew D Galbraith, Keith P Smith, Kelly D Sullivan, Ross E Granrath, Belinda Enriquez-Estrada, Kohl T Kinning, Jessica R Shaw, Angela L Rachubinski, Joaquin M Espinosa, James DeGregori
No abstract text is available yet for this article.
April 13, 2021: Blood Advances
#36
Adriane Esquivel-Muelbert, Oliver L Phillips, Roel J W Brienen, Sophie Fauset, Martin J P Sullivan, Timothy R Baker, Kuo-Jung Chao, Ted R Feldpausch, Emanuel Gloor, Niro Higuchi, Jeanne Houwing-Duistermaat, Jon Lloyd, Haiyan Liu, Yadvinder Malhi, Beatriz Marimon, Ben Hur Marimon Junior, Abel Monteagudo-Mendoza, Lourens Poorter, Marcos Silveira, Emilio Vilanova Torre, Esteban Alvarez Dávila, Jhon Del Aguila Pasquel, Everton Almeida, Patricia Alvarez Loayza, Ana Andrade, Luiz E O C Aragão, Alejandro Araujo-Murakami, Eric Arets, Luzmila Arroyo, Gerardo A Aymard C, Michel Baisie, Christopher Baraloto, Plínio Barbosa Camargo, Jorcely Barroso, Lilian Blanc, Damien Bonal, Frans Bongers, René Boot, Foster Brown, Benoit Burban, José Luís Camargo, Wendeson Castro, Victor Chama Moscoso, Jerome Chave, James Comiskey, Fernando Cornejo Valverde, Antonio Lola da Costa, Nallaret Davila Cardozo, Anthony Di Fiore, Aurélie Dourdain, Terry Erwin, Gerardo Flores Llampazo, Ima Célia Guimarães Vieira, Rafael Herrera, Eurídice Honorio Coronado, Isau Huamantupa-Chuquimaco, Eliana Jimenez-Rojas, Timothy Killeen, Susan Laurance, William Laurance, Aurora Levesley, Simon L Lewis, Karina Liana Lisboa Melgaço Ladvocat, Gabriela Lopez-Gonzalez, Thomas Lovejoy, Patrick Meir, Casimiro Mendoza, Paulo Morandi, David Neill, Adriano José Nogueira Lima, Percy Nuñez Vargas, Edmar Almeida de Oliveira, Nadir Pallqui Camacho, Guido Pardo, Julie Peacock, Marielos Peña-Claros, Maria Cristina Peñuela-Mora, Georgia Pickavance, John Pipoly, Nigel Pitman, Adriana Prieto, Thomas A M Pugh, Carlos Quesada, Hirma Ramirez-Angulo, Simone Matias de Almeida Reis, Maxime Rejou-Machain, Zorayda Restrepo Correa, Lily Rodriguez Bayona, Agustín Rudas, Rafael Salomão, Julio Serrano, Javier Silva Espejo, Natalino Silva, James Singh, Clement Stahl, Juliana Stropp, Varun Swamy, Joey Talbot, Hans Ter Steege, John Terborgh, Raquel Thomas, Marisol Toledo, Armando Torres-Lezama, Luis Valenzuela Gamarra, Geertje van der Heijden, Peter van der Meer, Peter van der Hout, Rodolfo Vasquez Martinez, Simone Aparecida Vieira, Jeanneth Villalobos Cayo, Vincent Vos, Roderick Zagt, Pieter Zuidema, David Galbraith
No abstract text is available yet for this article.
January 4, 2021: Nature Communications
#37
JOURNAL ARTICLE
Sara M Galbraith, James H Cane, James W Rivers
Although ecological disturbances can have a strong influence on pollinators through changes in habitat, virtually no studies have quantified how characteristics of wildfire influence the demography of essential pollinators. Nevertheless, evaluating this topic is critical for understanding how wildfire is linked to pollinator population dynamics, particularly given recent changes in wildfire frequency and severity in many regions of the world. In this study, we measured the demographic response of the blue orchard bee (Osmia lignaria) across a natural gradient of wildfire severity to assess how variation in wildfire characteristics influenced reproductive output, offspring sex ratio, and offspring mass...
January 3, 2021: Oecologia
#38
JOURNAL ARTICLE
Adriane Esquivel-Muelbert, Oliver L Phillips, Roel J W Brienen, Sophie Fauset, Martin J P Sullivan, Timothy R Baker, Kuo-Jung Chao, Ted R Feldpausch, Emanuel Gloor, Niro Higuchi, Jeanne Houwing-Duistermaat, Jon Lloyd, Haiyan Liu, Yadvinder Malhi, Beatriz Marimon, Ben Hur Marimon Junior, Abel Monteagudo-Mendoza, Lourens Poorter, Marcos Silveira, Emilio Vilanova Torre, Esteban Alvarez Dávila, Jhon Del Aguila Pasquel, Everton Almeida, Patricia Alvarez Loayza, Ana Andrade, Luiz E O C Aragão, Alejandro Araujo-Murakami, Eric Arets, Luzmila Arroyo, Gerardo A Aymard C, Michel Baisie, Christopher Baraloto, Plínio Barbosa Camargo, Jorcely Barroso, Lilian Blanc, Damien Bonal, Frans Bongers, René Boot, Foster Brown, Benoit Burban, José Luís Camargo, Wendeson Castro, Victor Chama Moscoso, Jerome Chave, James Comiskey, Fernando Cornejo Valverde, Antonio Lola da Costa, Nallaret Davila Cardozo, Anthony Di Fiore, Aurélie Dourdain, Terry Erwin, Gerardo Flores Llampazo, Ima Célia Guimarães Vieira, Rafael Herrera, Eurídice Honorio Coronado, Isau Huamantupa-Chuquimaco, Eliana Jimenez-Rojas, Timothy Killeen, Susan Laurance, William Laurance, Aurora Levesley, Simon L Lewis, Karina Liana Lisboa Melgaço Ladvocat, Gabriela Lopez-Gonzalez, Thomas Lovejoy, Patrick Meir, Casimiro Mendoza, Paulo Morandi, David Neill, Adriano José Nogueira Lima, Percy Nuñez Vargas, Edmar Almeida de Oliveira, Nadir Pallqui Camacho, Guido Pardo, Julie Peacock, Marielos Peña-Claros, Maria Cristina Peñuela-Mora, Georgia Pickavance, John Pipoly, Nigel Pitman, Adriana Prieto, Thomas A M Pugh, Carlos Quesada, Hirma Ramirez-Angulo, Simone Matias de Almeida Reis, Maxime Rejou-Machain, Zorayda Restrepo Correa, Lily Rodriguez Bayona, Agustín Rudas, Rafael Salomão, Julio Serrano, Javier Silva Espejo, Natalino Silva, James Singh, Clement Stahl, Juliana Stropp, Varun Swamy, Joey Talbot, Hans Ter Steege, John Terborgh, Raquel Thomas, Marisol Toledo, Armando Torres-Lezama, Luis Valenzuela Gamarra, Geertje van der Heijden, Peter van der Meer, Peter van der Hout, Rodolfo Vasquez Martinez, Simone Aparecida Vieira, Jeanneth Villalobos Cayo, Vincent Vos, Roderick Zagt, Pieter Zuidema, David Galbraith
The carbon sink capacity of tropical forests is substantially affected by tree mortality. However, the main drivers of tropical tree death remain largely unknown. Here we present a pan-Amazonian assessment of how and why trees die, analysing over 120,000 trees representing > 3800 species from 189 long-term RAINFOR forest plots. While tree mortality rates vary greatly Amazon-wide, on average trees are as likely to die standing as they are broken or uprooted-modes of death with different ecological consequences...
November 9, 2020: Nature Communications
#39
JOURNAL ARTICLE
Sarah B Dubbs, Siamak Moayedi, James W Galbraith, Boris Lubavin, Amal Mattu, Micelle Haydel, Mohamad Ali Cheaito, Michael C Bond, Amin Kazzi
Emergency Medicine Interest Groups (EMIGs) serve as a bountiful resource for students interested in pursuing a career in Emergency Medicine (EM). In this article we elaborate on how medical students can get involved as members in an EMIG, discuss opportunities for leadership through these groups, detail how to make the most out of the EMIG (including a listing of important lectures, workshops/labs and opportunities for growth and advancement), provide a framework for how to institute a new EMIG when one does not exist, and discuss considerations for international EMIG groups...
October 27, 2020: Journal of Emergency Medicine
#40
JOURNAL ARTICLE
James D Galbraith, Alastair J Ludington, Alexander Suh, Kate L Sanders, David L Adelson
While numerous studies have found horizontal transposon transfer (HTT) to be widespread across metazoans, few have focused on HTT in marine ecosystems. To investigate potential recent HTTs into marine species we searched for novel repetitive elements in sea snakes, a group of elapids which transitioned to a marine habitat at most 18 Mya. Our analysis uncovered repeated HTTs into sea snakes following their marine transition. The 7 subfamilies of horizontally transferred LINE retrotransposons we identified in the olive sea snake (Aipysurus laevis) are transcribed, and hence are likely still active and expanding across the genome...
October 6, 2020: Genome Biology and Evolution
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