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Galbraith james

András Kotschy, Zoltán Szlavik, James Murray, James Davidson, Ana Leticia Maragno, Gaëtane Le Toumelin-Braizat, Maïa Chanrion, Gemma L Kelly, Jia-Nan Gong, Donia M Moujalled, Alain Bruno, Márton Csekei, Attila Paczal, Zoltán B Szabo, Szabolcs Sipos, Gábor Radics, Agnes Proszenyak, Balázs Balint, Levente Ondi, Gábor Blasko, Alan Robertson, Allan Surgenor, Pawel Dokurno, Ijen Chen, Natalia Matassova, Julia Smith, Christopher Pedder, Christopher Graham, Aurélie Studeny, Gaëlle Lysiak-Auvity, Anne-Marie Girard, Fabienne Gravé, David Segal, Chris D Riffkin, Giovanna Pomilio, Laura C A Galbraith, Brandon J Aubrey, Margs S Brennan, Marco J Herold, Catherine Chang, Ghislaine Guasconi, Nicolas Cauquil, Fabien Melchiore, Nolwen Guigal-Stephan, Brian Lockhart, Frédéric Colland, John A Hickman, Andrew W Roberts, David C S Huang, Andrew H Wei, Andreas Strasser, Guillaume Lessene, Olivier Geneste
Avoidance of apoptosis is critical for the development and sustained growth of tumours. The pro-survival protein myeloid cell leukemia 1 (MCL1) is overexpressed in many cancers, but the development of small molecules targeting this protein that are amenable for clinical testing has been challenging. Here we describe S63845, a small molecule that specifically binds with high affinity to the BH3-binding groove of MCL1. Our mechanistic studies demonstrate that S63845 potently kills MCL1-dependent cancer cells, including multiple myeloma, leukaemia and lymphoma cells, by activating the BAX/BAK-dependent mitochondrial apoptotic pathway...
October 19, 2016: Nature
Croix J Laconsay, Andrew M James, John Morrison Galbraith
In an effort to understand the theoretical parameters of charge-shift bonding, computational experiments have been designed to elucidate the factors effecting molecular resonance energy. Valence bond theory calculations have been used to calculate resonance energies of homonuclear bonds in the series [HnX-XHn](Z), where n = 0-3 and Z = 2n - 6, 2n - 4, 2n - 2, and 2n for X = C, N, O, and F respectively. It is shown that the resonance energy decreases as the number of lone pairs increases. Calculated orbital contraction coefficients show that this unexpected result is due to the dominance of orbital size over the lone pair effect...
October 10, 2016: Journal of Physical Chemistry. A
John G Galbraith, Charles J Daly, James A Harty, Hannah L Dailey
BACKGROUND: For tibial fractures, the decision to fix a concomitant fibular fracture is undertaken on a case-by-case basis. To aid in this clinical decision-making process, we investigated whether loss of integrity of the fibula significantly destabilises midshaft tibial fractures, whether fixation of the fibula restores stability to the tibia, and whether removal of the fibula and interosseous membrane for expediency in biomechanical testing significantly influences tibial interfragmentary mechanics...
October 2016: Clinical Biomechanics
Kelly D Sullivan, Hannah C Lewis, Amanda A Hill, Ahwan Pandey, Leisa P Jackson, Joseph M Cabral, Keith P Smith, L Alexander Liggett, Eliana B Gomez, Matthew D Galbraith, James DeGregori, Joaquín M Espinosa
Although it is clear that trisomy 21 causes Down syndrome, the molecular events acting downstream of the trisomy remain ill defined. Using complementary genomics analyses, we identified the interferon pathway as the major signaling cascade consistently activated by trisomy 21 in human cells. Transcriptome analysis revealed that trisomy 21 activates the interferon transcriptional response in fibroblast and lymphoblastoid cell lines, as well as circulating monocytes and T cells. Trisomy 21 cells show increased induction of interferon-stimulated genes and decreased expression of ribosomal proteins and translation factors...
2016: ELife
Jane V Carter, Henry L Roberts, Jianmin Pan, Jonathan D Rice, James F Burton, Norman J Galbraith, Maurice R Eichenberger, Jeffery Jorden, Peter Deveaux, Russell Farmer, Anna Williford, Ziad Kanaan, Shesh N Rai, Susan Galandiuk
OBJECTIVE: To develop a plasma-based microRNA (miRNA) diagnostic assay specific for colorectal neoplasms, building upon our prior work. BACKGROUND: Colorectal neoplasms [colorectal cancer (CRC) and colorectal advanced adenoma (CAA)] frequently develop in individuals at ages when other common cancers also occur. Current screening methods lack sensitivity, specificity, and have poor patient compliance. METHODS: Plasma was screened for 380 miRNAs using microfluidic array technology from a "Training" cohort of 60 patients, (10 each) control, CRC, CAA, breast cancer, pancreatic cancer, and lung cancer...
October 2016: Annals of Surgery
Thomas E Serena, Breda M Cullen, Simon W Bayliff, Molly C Gibson, Marissa J Carter, Lingyun Chen, Raphael A Yaakov, John Samies, Matthew Sabo, Daniel DeMarco, Namchi Le, James Galbraith
It is widely accepted that elevated protease activity (EPA) in chronic wounds impedes healing. However, little progress has occurred in quantifying the level of protease activity that is detrimental for healing. The aim of this study was to determine the relationship between inflammatory protease activity and wound healing status, and to establish the level of EPA above which human neutrophil-derived elastase (HNE) and matrix metalloproteases (MMP) activities correlate with nonhealing wounds. Chronic wound swab samples (n = 290) were collected from four wound centers across the USA to measure HNE and MMP activity...
May 2016: Wound Repair and Regeneration
Khuloud Jaqaman, James A Galbraith, Michael W Davidson, Catherine G Galbraith
Recent advances in light microscopy permit visualization of the behavior of individual molecules within dense macromolecular ensembles in live cells. It is now conceptually possible to relate the dynamic organization of molecular machinery to cellular function. However, inherent heterogeneities, as well as disparities between spatial and temporal scales, pose substantial challenges in deriving such a relationship. New approaches are required to link discrete single-molecule behavior with continuous cellular-level processes...
May 15, 2016: Molecular Biology of the Cell
Ta-Hsuan Ong, Elena V Romanova, Rachel H Roberts-Galbraith, Ning Yang, Tyler A Zimmerman, James J Collins, Ji Eun Lee, Neil L Kelleher, Phillip A Newmark, Jonathan V Sweedler
Tissue regeneration is a complex process that involves a mosaic of molecules that vary spatially and temporally. Insights into the chemical signaling underlying this process can be achieved with a multiplex and untargeted chemical imaging method such as mass spectrometry imaging (MSI), which can enablede novostudies of nervous system regeneration. A combination of MSI and multivariate statistics was used to differentiate peptide dynamics in the freshwater planarian flatwormSchmidtea mediterraneaat different time points during cephalic ganglia regeneration...
April 8, 2016: Journal of Biological Chemistry
James W Galbraith, James H Willig, Joel B Rodgers, John P Donnelly, Andrew O Westfall, Kelly L Ross-Davis, Sonya L Heath
OBJECTIVE: The Centers for Disease Control and Prevention has recommended emergency department (ED) opt-out HIV screening since 2006. Routine screening can prove challenging due to the ED's complexity and competing priorities. This study examined the implementation and evolution of a routine, integrated, opt-out HIV screening program at an urban academic ED in Alabama since August 2011. METHODS: ED routine, opt-out HIV screening was implemented as a standard of care in September 2011...
January 2016: Public Health Reports
John P Donnelly, Ricardo A Franco, Henry E Wang, James W Galbraith
Hepatitis C virus (HCV) infection is a growing problem, disproportionately affecting those born between 1945 and 1965. Here, we demonstrate the wide geographic reach and surveillance potential of emergency department-based screening and identify areas of elevated HCV infection in central Alabama that were socioeconomically disadvantaged compared with surrounding communities.
March 1, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Worth L Barbour, Joel B Rodgers, Henry E Wang, John P Donnelly, Amanda M Tapley, James W Galbraith
OBJECTIVES: Adolescents are at greater risk for acquiring human immunodeficiency virus (HIV) due to increased risk behaviors. Parental influence is known to reduce adolescent risk behaviors. We compared HIV risk behaviors reported by adolescents to parents' perception of adolescent risky behavior engagement. We also examined participants' knowledge of HIV transmission and testing preferences. METHODS: Participants included English-speaking adolescents and parents presenting to a pediatric emergency department...
November 6, 2015: Pediatric Emergency Care
James W Galbraith
No abstract text is available yet for this article.
January 2016: Annals of Emergency Medicine
Danielle A Southern, Jennifer Ngo, Billie-Jean Martin, P Diane Galbraith, Merril L Knudtson, William A Ghali, Matthew T James, Stephen B Wilton
BACKGROUND: Thirty-day readmission rates have been tied to hospital reimbursement in the United States, but remain controversial as measures of healthcare quality. We profile the timing, main diagnoses, and survival outcomes of inpatient and emergency department readmissions after acute coronary syndrome (ACS), based on a large regional database. METHODS AND RESULTS: Patients enrolled in the Alberta Provincial Project for Outcomes Assessment in Coronary Heart Disease (APPROACH) registry with an ACS hospitalization between April 2008 and March 2010 (n=3411) were included...
October 2014: Journal of the American Heart Association
James W Galbraith, Ricardo A Franco, John P Donnelly, Joel B Rodgers, Jordan M Morgan, Andres F Viles, Edgar T Overton, Michael S Saag, Henry E Wang
UNLABELLED: The Centers for Disease Control and Prevention and U.S. Preventive Services Task Force have highlighted public screening as an essential strategy for increasing hepatitis C virus (HCV) detection in persons born between 1945 and 1965 ("baby boomers"). Because earlier HCV screening efforts have not targeted emergency department (ED) baby boomer patients, we describe early experience with integrated opt-out HCV antibody (Ab) screening of medically stable baby boomers presenting to an urban academic ED...
March 2015: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Paul M Foreman, James M Markert, Arnold G Diethelm, Mark N Hadley
: The Division of Neurosurgery at the University of Alabama at Birmingham was formally founded in 1954 under the leadership of James Garber Galbraith. The following 60 years would see neurosurgery at the forefront of the development of a nationally recognized medical center in the heart of Birmingham, Alabama. The Department of Neurosurgery now employs 14 faculty members, performs more than 4500 neurosurgical procedures annually, is active in clinical and laboratory research, and boasts a contemporary, comprehensive residency training program...
October 2014: Neurosurgery
James W Galbraith, John P Donnelly, Ricardo A Franco, Edgar T Overton, Joel B Rodgers, Henry E Wang
BACKGROUND: Hepatitis C virus (HCV) infection is a major public health problem in the United States. Although prior studies have evaluated the HCV-related healthcare burden, these studies examined a single treatment setting and did not account for the growing "baby boomer" population (individuals born during 1945-1965). METHODS: Data from the National Ambulatory Medical Care Survey, the National Hospital Ambulatory Medical Care Survey, and the Nationwide Inpatient Sample were analyzed...
September 15, 2014: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Brent D Kerger, Robert C James, David A Galbraith
The diagnosis of mesothelioma is not always straightforward, despite known immunohistochemical markers and other diagnostic techniques. One reason for the difficulty is that extrapleural tumors resembling mesothelioma may have several possible etiologies, especially in cases with no meaningful history of amphibole asbestos exposure. When the diagnosis of mesothelioma is based on histologic features alone, primary mesotheliomas may resemble various primary or metastatic cancers that have directly invaded the serosal membranes...
2014: Frontiers in Genetics
Veronica C Lee, Patrick Muriithi, Ulrike Gilbert-Nandra, Andrea A Kim, Mary E Schmitz, James Odek, Rose Mokaya, Jennifer S Galbraith
BACKGROUND: In Kenya, it is estimated that there are approximately 3.6 million children aged <18 years who have been orphaned or who are vulnerable. We examined the data from the second Kenya AIDS Indicator Survey (KAIS 2012) to determine the number and profile of orphans and vulnerable children (OVC) in Kenya who were aged <18 years. METHODS: KAIS 2012 was a nationally representative, population-based household survey. We analyzed the data for all the children from birth to age 17 years who resided in an eligible household so as to determine whether their parents were alive or had been very ill to define their OVC status...
May 1, 2014: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Khine M Su, John L Crompton, Dinesh Selva, James Ek Galbraith
No abstract text is available yet for this article.
December 2014: Clinical & Experimental Ophthalmology
Morgan D Wilbanks, James W Galbraith, William M Geisler
INTRODUCTION: The clinical presentation of genital Chlamydia trachomatis infection (chlamydia) in women is often indistinguishable from a urinary tract infection. While merited in the setting of dysuria, emergency department (ED) clinicians do not routinely test for chlamydia in women. The primary aim of our study was to evaluate the frequency of chlamydia testing among women presenting to the ED with dysuria. METHODS: We conducted a retrospective chart review of women 19-25 years of age presenting with dysuria to an urban ED and who had been coded with urinary tract infection (UTI) as their primary diagnosis (ICD-9 599...
March 2014: Western Journal of Emergency Medicine
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