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https://www.readbyqxmd.com/read/28335723/erratum-to-unity-in-defence-honeybee-workers-exhibit-conserved-molecular-responses-to-diverse-pathogens
#1
Vincent Doublet, Yvonne Poeschl, Andreas Gogol-Döring, Cédric Alaux, Desiderato Annoscia, Christian Aurori, Seth M Barribeau, Oscar C Bedoya-Reina, Mark J F Brown, James C Bull, Michelle L Flenniken, David A Galbraith, Elke Genersch, Sebastian Gisder, Ivo Grosse, Holly L Holt, Dan Hultmark, H Michael G Lattorff, Yves Le Conte, Fabio Manfredini, Dino P McMahon, Robin F A Moritz, Francesco Nazzi, Elina L Niño, Katja Nowick, Ronald P van Rij, Robert J Paxton, Christina M Grozinger
No abstract text is available yet for this article.
March 23, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28295769/hill-robertson-interference-maintained-by-red-queen-dynamics-favours-the-evolution-of-sex
#2
Jack da Silva, James D Galbraith
Although it is well established theoretically that selective interference among mutations (Hill-Robertson interference) favours meiotic recombination, genome-wide mean rates of mutation and strengths of selection appear too low to support this as the mechanism favouring recombination in nature. A possible solution to this discrepancy between theory and observation is that selection is at least intermittently very strong due to the antagonistic coevolution between a host and its parasites. The Red Queen theory posits that such coevolution generates fitness epistasis among loci, which generates negative linkage disequilibrium among beneficial mutations, which in turn favours recombination...
March 15, 2017: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/28249569/unity-in-defence-honeybee-workers-exhibit-conserved-molecular-responses-to-diverse-pathogens
#3
Vincent Doublet, Yvonne Poeschl, Andreas Gogol-Döring, Cédric Alaux, Desiderato Annoscia, Christian Aurori, Seth M Barribeau, Oscar C Bedoya-Reina, Mark J F Brown, James C Bull, Michelle L Flenniken, David A Galbraith, Elke Genersch, Sebastian Gisder, Ivo Grosse, Holly L Holt, Dan Hultmark, H Michael G Lattorff, Yves Le Conte, Fabio Manfredini, Dino P McMahon, Robin F A Moritz, Francesco Nazzi, Elina L Niño, Katja Nowick, Ronald P van Rij, Robert J Paxton, Christina M Grozinger
BACKGROUND: Organisms typically face infection by diverse pathogens, and hosts are thought to have developed specific responses to each type of pathogen they encounter. The advent of transcriptomics now makes it possible to test this hypothesis and compare host gene expression responses to multiple pathogens at a genome-wide scale. Here, we performed a meta-analysis of multiple published and new transcriptomes using a newly developed bioinformatics approach that filters genes based on their expression profile across datasets...
March 2, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28207069/continuum-of-care-for-hcv-among-patients-diagnosed-in-the-emergency-department-setting
#4
Erik S Anderson, James W Galbraith, Laura J Deering, Sarah K Pfeil, Tamara Todorovic, Joel B Rodgers, Jordan M Forsythe, Ricardo Franco, Henry Wang, N Ewen Wang, Douglas A E White
No abstract text is available yet for this article.
February 16, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28152545/blood-based-micrornas-as-biomarkers-for-the-diagnosis-of-colorectal-cancer-a-systematic-review-and-meta-analysis
#5
Jane V Carter, Norman J Galbraith, Dongyan Yang, James F Burton, Samuel P Walker, Susan Galandiuk
BACKGROUND: Colorectal cancer (CRC) is common and associated with significant mortality. Current screening methods for CRC lack patient compliance. microRNAs (miRNAs), identified in body fluids, are negative regulators of gene expression and are dysregulated in many cancers, including CRC. This paper summarises studies identifying blood-based miRNAs dysregulated in CRC compared with healthy controls in an attempt to evaluate their use as a screening tool for the diagnosis of CRC. METHODS: A search of electronic databases (PubMed and EMBASE) and grey literature was performed between January 2002 and April 2016...
March 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28066793/characterizing-failure-to-establish-hepatitis-c-care-of-baby-boomers-diagnosed-in-the-emergency-department
#6
Ricardo A Franco, E Turner Overton, Ashutosh R Tamhane, Jordan M Forsythe, Joel B Rodgers, Julie K Schexnayder, Deanne Guthrie, Suneetha Thogaripally, Anne Zinski, Michael S Saag, Michael J Mugavero, Henry E Wang, James W Galbraith
BACKGROUND: Emergency departments (EDs) are high-yield sites for hepatitis C virus (HCV) screening, but data regarding linkage to care (LTC) determinants are limited. METHODS: Between September 2013 and June 2014, 4371 baby boomers unaware of their HCV status presented to the University of Alabama at Birmingham ED and underwent opt-out screening. A linkage coordinator facilitated referrals for positive cases. Demographic data, International Classification of Diseases, Ninth Revision codes, and clinic visits were collected, and patients were (retrospectively) followed up until February 2015...
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27974517/evolutionary-heritage-influences-amazon-tree-ecology
#7
Fernanda Coelho de Souza, Kyle G Dexter, Oliver L Phillips, Roel J W Brienen, Jerome Chave, David R Galbraith, Gabriela Lopez Gonzalez, Abel Monteagudo Mendoza, R Toby Pennington, Lourens Poorter, Miguel Alexiades, Esteban Álvarez-Dávila, Ana Andrade, Luis E O C Aragão, Alejandro Araujo-Murakami, Eric J M M Arets, Gerardo A Aymard C, Christopher Baraloto, Jorcely G Barroso, Damien Bonal, Rene G A Boot, José L C Camargo, James A Comiskey, Fernando Cornejo Valverde, Plínio B de Camargo, Anthony Di Fiore, Fernando Elias, Terry L Erwin, Ted R Feldpausch, Leandro Ferreira, Nikolaos M Fyllas, Emanuel Gloor, Bruno Herault, Rafael Herrera, Niro Higuchi, Eurídice N Honorio Coronado, Timothy J Killeen, William F Laurance, Susan Laurance, Jon Lloyd, Thomas E Lovejoy, Yadvinder Malhi, Leandro Maracahipes, Beatriz S Marimon, Ben H Marimon-Junior, Casimiro Mendoza, Paulo Morandi, David A Neill, Percy Núñez Vargas, Edmar A Oliveira, Eddie Lenza, Walter A Palacios, Maria C Peñuela-Mora, John J Pipoly, Nigel C A Pitman, Adriana Prieto, Carlos A Quesada, Hirma Ramirez-Angulo, Agustin Rudas, Kalle Ruokolainen, Rafael P Salomão, Marcos Silveira, Juliana Stropp, Hans Ter Steege, Raquel Thomas-Caesar, Peter van der Hout, Geertje M F van der Heijden, Peter J van der Meer, Rodolfo V Vasquez, Simone A Vieira, Emilio Vilanova, Vincent A Vos, Ophelia Wang, Kenneth R Young, Roderick J Zagt, Timothy R Baker
Lineages tend to retain ecological characteristics of their ancestors through time. However, for some traits, selection during evolutionary history may have also played a role in determining trait values. To address the relative importance of these processes requires large-scale quantification of traits and evolutionary relationships among species. The Amazonian tree flora comprises a high diversity of angiosperm lineages and species with widely differing life-history characteristics, providing an excellent system to investigate the combined influences of evolutionary heritage and selection in determining trait variation...
December 14, 2016: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/27868200/impact-of-copayment-changes-on-children-s-albuterol-inhaler-use-and-costs-after-the-clean-air-act-chlorofluorocarbon-ban
#8
Alison A Galbraith, Vicki Fung, Lingling Li, Melissa G Butler, James D Nordin, John Hsu, David Smith, William M Vollmer, Tracy A Lieu, Stephen B Soumerai, Ann Chen Wu
OBJECTIVE: To examine changes in children's albuterol use and out-of-pocket (OOP) costs in response to increased copayments after the Food and Drug Administration banned inhalers with chlorofluorocarbon (CFC) propellants. SETTING: Four health maintenance organizations (HMOs), two that increased copayments for albuterol inhalers that went from generic CFC-containing to branded CFC-free versions, and two that retained generic copayments for CFC-free inhalers (controls)...
November 20, 2016: Health Services Research
https://www.readbyqxmd.com/read/27862363/a-comprehensive-microbiological-safety-approach-for-agarose-encapsulated-porcine-islets-intended-for-clinical-trials
#9
Lawrence S Gazda, James Collins, Archie Lovatt, Robert W Holdcraft, Merribeth J Morin, Daniel Galbraith, Melanie Graham, Melissa A Laramore, Christine Maclean, John Black, Euan W Milne, Douglas G Marthaler, Horatiu V Vinerean, Michelle M Michalak, Deborah Hoffer, Steven Richter, Richard D Hall, Barry H Smith
BACKGROUND: The use of porcine islets to replace insulin-producing islet β-cells, destroyed during the diabetogenic disease process, presents distinct challenges if this option is to become a therapeutic reality for the treatment of type 1 diabetes. These challenges include a thorough evaluation of the microbiological safety of the islets. In this study, we describe a robust porcine islet-screening program that provides a high level of confidence in the microbiological safety of porcine islets suitable for clinical trials...
November 2016: Xenotransplantation
https://www.readbyqxmd.com/read/27792659/serum-total-25-oh-vitamin-d-adds-little-prognostic-value-in-patients-undergoing-coronary-catheterization
#10
Michael E Gerling, Matthew T James, Stephen B Wilton, Christopher Naugler, Danielle A Southern, P Diane Galbraith, Merril Knudtson, Lawrence de Koning
BACKGROUND: Vitamin D deficiency is associated with an increased risk of cardiovascular disease; however, it is unclear whether vitamin D status should be considered in clinical risk assessments of patients with cardiovascular disease. METHODS AND RESULTS: This study included 2975 patients who had their first serum total 25-hydroxy vitamin D (25-OH vitamin D) measurement before their first coronary catheterization in Alberta, Canada. Cox regression was used to examine associations between 25-OH vitamin D and mortality risk after adjusting for demographic and clinical risk factors...
October 21, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27760111/the-mcl1-inhibitor-s63845-is-tolerable-and-effective-in-diverse-cancer-models
#11
András Kotschy, Zoltán Szlavik, James Murray, James Davidson, Ana Leticia Maragno, Gaëtane Le Toumelin-Braizat, Maïa Chanrion, Gemma L Kelly, Jia-Nan Gong, Donia M Moujalled, Alain Bruno, Márton Csekei, Attila Paczal, Zoltán B Szabo, Szabolcs Sipos, Gábor Radics, Agnes Proszenyak, Balázs Balint, Levente Ondi, Gábor Blasko, Alan Robertson, Allan Surgenor, Pawel Dokurno, Ijen Chen, Natalia Matassova, Julia Smith, Christopher Pedder, Christopher Graham, Aurélie Studeny, Gaëlle Lysiak-Auvity, Anne-Marie Girard, Fabienne Gravé, David Segal, Chris D Riffkin, Giovanna Pomilio, Laura C A Galbraith, Brandon J Aubrey, Margs S Brennan, Marco J Herold, Catherine Chang, Ghislaine Guasconi, Nicolas Cauquil, Fabien Melchiore, Nolwen Guigal-Stephan, Brian Lockhart, Frédéric Colland, John A Hickman, Andrew W Roberts, David C S Huang, Andrew H Wei, Andreas Strasser, Guillaume Lessene, Olivier Geneste
Avoidance of apoptosis is critical for the development and sustained growth of tumours. The pro-survival protein myeloid cell leukemia 1 (MCL1) is overexpressed in many cancers, but the development of small molecules targeting this protein that are amenable for clinical testing has been challenging. Here we describe S63845, a small molecule that specifically binds with high affinity to the BH3-binding groove of MCL1. Our mechanistic studies demonstrate that S63845 potently kills MCL1-dependent cancer cells, including multiple myeloma, leukaemia and lymphoma cells, by activating the BAX/BAK-dependent mitochondrial apoptotic pathway...
October 27, 2016: Nature
https://www.readbyqxmd.com/read/27723345/the-effect-of-lone-pairs-on-molecular-resonance-energy
#12
Croix J Laconsay, Andrew M James, John Morrison Galbraith
In an effort to understand the theoretical parameters of charge-shift bonding, computational experiments have been designed to elucidate the factors effecting molecular resonance energy. Valence bond theory calculations have been used to calculate resonance energies of homonuclear bonds in the series [HnX-XHn](Z), where n = 0-3 and Z = 2n - 6, 2n - 4, 2n - 2, and 2n for X = C, N, O, and F respectively. It is shown that the resonance energy decreases as the number of lone pairs increases. Calculated orbital contraction coefficients show that this unexpected result is due to the dominance of orbital size over the lone pair effect...
October 10, 2016: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/27566982/role-of-the-fibula-in-the-stability-of-diaphyseal-tibial-fractures-fixed-by-intramedullary-nailing
#13
John G Galbraith, Charles J Daly, James A Harty, Hannah L Dailey
BACKGROUND: For tibial fractures, the decision to fix a concomitant fibular fracture is undertaken on a case-by-case basis. To aid in this clinical decision-making process, we investigated whether loss of integrity of the fibula significantly destabilises midshaft tibial fractures, whether fixation of the fibula restores stability to the tibia, and whether removal of the fibula and interosseous membrane for expediency in biomechanical testing significantly influences tibial interfragmentary mechanics...
October 2016: Clinical Biomechanics
https://www.readbyqxmd.com/read/27472900/trisomy-21-consistently-activates-the-interferon-response
#14
Kelly D Sullivan, Hannah C Lewis, Amanda A Hill, Ahwan Pandey, Leisa P Jackson, Joseph M Cabral, Keith P Smith, L Alexander Liggett, Eliana B Gomez, Matthew D Galbraith, James DeGregori, Joaquín M Espinosa
Although it is clear that trisomy 21 causes Down syndrome, the molecular events acting downstream of the trisomy remain ill defined. Using complementary genomics analyses, we identified the interferon pathway as the major signaling cascade consistently activated by trisomy 21 in human cells. Transcriptome analysis revealed that trisomy 21 activates the interferon transcriptional response in fibroblast and lymphoblastoid cell lines, as well as circulating monocytes and T cells. Trisomy 21 cells show increased induction of interferon-stimulated genes and decreased expression of ribosomal proteins and translation factors...
July 29, 2016: ELife
https://www.readbyqxmd.com/read/27471839/a-highly-predictive-model-for-diagnosis-of-colorectal-neoplasms-using-plasma-microrna-improving-specificity-and-sensitivity
#15
Jane V Carter, Henry L Roberts, Jianmin Pan, Jonathan D Rice, James F Burton, Norman J Galbraith, Maurice R Eichenberger, Jeffery Jorden, Peter Deveaux, Russell Farmer, Anna Williford, Ziad Kanaan, Shesh N Rai, Susan Galandiuk
OBJECTIVE: To develop a plasma-based microRNA (miRNA) diagnostic assay specific for colorectal neoplasms, building upon our prior work. BACKGROUND: Colorectal neoplasms [colorectal cancer (CRC) and colorectal advanced adenoma (CAA)] frequently develop in individuals at ages when other common cancers also occur. Current screening methods lack sensitivity, specificity, and have poor patient compliance. METHODS: Plasma was screened for 380 miRNAs using microfluidic array technology from a "Training" cohort of 60 patients, (10 each) control, CRC, CAA, breast cancer, pancreatic cancer, and lung cancer...
October 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27027492/defining-a-new-diagnostic-assessment-parameter-for-wound-care-elevated-protease-activity-an-indicator-of-nonhealing-for-targeted-protease-modulating-treatment
#16
Thomas E Serena, Breda M Cullen, Simon W Bayliff, Molly C Gibson, Marissa J Carter, Lingyun Chen, Raphael A Yaakov, John Samies, Matthew Sabo, Daniel DeMarco, Namchi Le, James Galbraith
It is widely accepted that elevated protease activity (EPA) in chronic wounds impedes healing. However, little progress has occurred in quantifying the level of protease activity that is detrimental for healing. The aim of this study was to determine the relationship between inflammatory protease activity and wound healing status, and to establish the level of EPA above which human neutrophil-derived elastase (HNE) and matrix metalloproteases (MMP) activities correlate with nonhealing wounds. Chronic wound swab samples (n = 290) were collected from four wound centers across the USA to measure HNE and MMP activity...
May 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/27009207/changes-in-single-molecule-integrin-dynamics-linked-to-local-cellular-behavior
#17
Khuloud Jaqaman, James A Galbraith, Michael W Davidson, Catherine G Galbraith
Recent advances in light microscopy permit visualization of the behavior of individual molecules within dense macromolecular ensembles in live cells. It is now conceptually possible to relate the dynamic organization of molecular machinery to cellular function. However, inherent heterogeneities, as well as disparities between spatial and temporal scales, pose substantial challenges in deriving such a relationship. New approaches are required to link discrete single-molecule behavior with continuous cellular-level processes...
May 15, 2016: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/26884331/mass-spectrometry-imaging-and-identification-of-peptides-associated-with-cephalic-ganglia-regeneration-in-schmidtea-mediterranea
#18
Ta-Hsuan Ong, Elena V Romanova, Rachel H Roberts-Galbraith, Ning Yang, Tyler A Zimmerman, James J Collins, Ji Eun Lee, Neil L Kelleher, Phillip A Newmark, Jonathan V Sweedler
Tissue regeneration is a complex process that involves a mosaic of molecules that vary spatially and temporally. Insights into the chemical signaling underlying this process can be achieved with a multiplex and untargeted chemical imaging method such as mass spectrometry imaging (MSI), which can enablede novostudies of nervous system regeneration. A combination of MSI and multivariate statistics was used to differentiate peptide dynamics in the freshwater planarian flatwormSchmidtea mediterraneaat different time points during cephalic ganglia regeneration...
April 8, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/26862235/evolution-and-escalation-of-an-emergency-department-routine-opt-out-hiv-screening-and-linkage-to-care-program
#19
James W Galbraith, James H Willig, Joel B Rodgers, John P Donnelly, Andrew O Westfall, Kelly L Ross-Davis, Sonya L Heath
OBJECTIVE: The Centers for Disease Control and Prevention has recommended emergency department (ED) opt-out HIV screening since 2006. Routine screening can prove challenging due to the ED's complexity and competing priorities. This study examined the implementation and evolution of a routine, integrated, opt-out HIV screening program at an urban academic ED in Alabama since August 2011. METHODS: ED routine, opt-out HIV screening was implemented as a standard of care in September 2011...
January 2016: Public Health Reports
https://www.readbyqxmd.com/read/26611776/emergency-department-screening-for-hepatitis-c-virus-geographic-reach-and-spatial-clustering-in-central-alabama
#20
John P Donnelly, Ricardo A Franco, Henry E Wang, James W Galbraith
Hepatitis C virus (HCV) infection is a growing problem, disproportionately affecting those born between 1945 and 1965. Here, we demonstrate the wide geographic reach and surveillance potential of emergency department-based screening and identify areas of elevated HCV infection in central Alabama that were socioeconomically disadvantaged compared with surrounding communities.
March 1, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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