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https://www.readbyqxmd.com/read/23414215/triggering-receptor-expressed-on-myeloid-cells-1-trem-1-on-blood-neutrophils-is-associated-with-cytokine-inducibility-in-human-e-coli-sepsis
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Tobias van Bremen, Daniel Drömann, Karin Luitjens, Christoph Dodt, Klaus Dalhoff, Torsten Goldmann, Bernhard Schaaf
BACKGROUND: Bacterial sepsis induced immunsuppression via antigen hyporesponsibility increases the risk of nosokomial infections and mortality. Pattern recognition receptors (PRR) might have a central role in the pathophysiology of hyporesponsibility. METHODS: In this study we evaluated in a human E. coli sepsis cohort, the role of PRR including TLR's and Trem-1. Expression of Trem-1, TLR2, TLR4, CD14 and HLA-DR on blood monozytes and neutrophils were examined using flow cytometry from 22 patients with E...
2013: Diagnostic Pathology
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