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Young-Hoo Kwon

Jongshin Kim, Yoo Hyung Kim, Jaeryung Kim, Do Young Park, Hosung Bae, Da-Hye Lee, Kyun Hoo Kim, Seon Pyo Hong, Seung Pil Jang, Yoshiaki Kubota, Young-Guen Kwon, Dae-Sik Lim, Gou Young Koh
Angiogenesis is a multistep process that requires coordinated migration, proliferation, and junction formation of vascular endothelial cells (ECs) to form new vessel branches in response to growth stimuli. Major intracellular signaling pathways that regulate angiogenesis have been well elucidated, but key transcriptional regulators that mediate these signaling pathways and control EC behaviors are only beginning to be understood. Here, we show that YAP/TAZ, a transcriptional coactivator that acts as an end effector of Hippo signaling, is critical for sprouting angiogenesis and vascular barrier formation and maturation...
August 14, 2017: Journal of Clinical Investigation
Yun-Sok Ha, Jae-Wook Chung, So Young Chun, Seock Hwan Choi, Jun Nyung Lee, Bum Soo Kim, Hyun Tae Kim, Tae-Hwan Kim, Seok-Soo Byun, Eu Chang Hwang, Seok Ho Kang, Sung-Hoo Hong, Jinsoo Chung, Cheol Kwak, Yong-June Kim, Tae Gyun Kwon
BACKGROUND: The prognostic significance of preoperative thrombocytosis (TC) in renal cell carcinoma (RCC) is not without some debate. The aim of the present multi-institutional study was to determine the association of preoperative TC with the clinicopathological features and prognosis of localized RCC patients who underwent surgery in a large cohort. METHODS: A study involving 8 institutions, and 4,376 patients with pT1 and pT2 RCC from the Korean renal cell carcinoma (KORCC) database, was conducted...
March 11, 2017: Oncotarget
Sung Han Kim, Sohee Kim, Byung-Ho Nam, Sang Eun Lee, Choung-Soo Kim, Ill Young Seo, Tae Nam Kim, Sung-Hoo Hong, Tae Gyun Kwon, Seong Il Seo, Kwan Joong Joo, Kanghyon Song, Cheol Kwak, Jinsoo Chung
We aimed to identify prognostic factors associated with progression-free survival (PFS) and overall survival (OS) in metastatic renal cell carcinoma (mRCC) patients treated with sorafenib. We investigated 177 patients, including 116 who received sorafenib as first-line therapy, using the Cox regression model. During a median follow-up period of 19.2 months, the PFS and OS were 6.4 and 32.6 months among all patients and 7.4 months and undetermined for first-line sorafenib-treated patients, respectively. Clinical T3-4 stage (hazard ratio [HR] 2...
2017: BioMed Research International
Yeo Hong Yun, Geum Ran Ahn, Seong Kwon Yoon, Hoo Hyun Kim, Seung Yeol Son, Seong Hwan Kim
During the growing season of 2015, leaf specimens with yellow rust spots were collected from Salix koreensis Andersson, known as Korean willow, in riverine areas in Cheonan, Korea. The fungus on S. koreensis was identified as the rust species, Melampsora yezoensis, based on the morphology of urediniospores observed by light and scanning electron microscopy, and the molecular properties of the internal transcribed spacer rDNA region. Pathogenicity tests confirmed that the urediniospores are the causal agent of the rust symptoms on the leaves and young stems of S...
December 2016: Mycobiology
Jin-Ki Hwang, Hong-Nu Yu, Eun-Mi Noh, Jeong-Mi Kim, On-Yu Hong, Hyun Jo Youn, Sung Hoo Jung, Kang-Beom Kwon, Jong-Suk Kim, Young-Rae Lee
Docosahexaenoic acid (DHA) is an omega-3 fatty acid that is considered to have applications in cancer prevention and treatment. The beneficial effects of DHA against cancer metastasis are well established; however, the mechanisms underlying these effects in breast cancer are not clear. Cell invasion is critical for neoplastic metastasis, and involves the degradation of the extracellular matrix by matrix metalloproteinase (MMP)-9. The present study investigated the inhibitory effect of DHA on MMP-9 expression and cell invasion induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in the MCF-7 breast cancer cell line...
January 2017: Oncology Letters
Ho Won Kang, Sung Pil Seo, Won Tae Kim, Seok Joong Yun, Sang Cheol Lee, Wun Jae Kim, Eu Chang Hwang, Seok Ho Kang, Sung Hoo Hong, Jinsoo Chung, Tae Gyun Kwon, Hyeon Hoe Kim, Cheol Kwak, Seok Soo Byun, Yong June Kim
The prognostic significance of age in renal cell carcinoma (RCC) is a subject of debate. The aim of the present multi-institutional study was to evaluate the impact of age on clinicopathological features and survival in a large cohort of patients with RCC. A total of 5,178 patients who underwent surgery for RCC at eight institutions in Korea between 1999 and 2011 were categorized into three groups according to age at diagnosis as follows: young age (< 40 years, n = 541), middle-age (≥ 40 and < 60 years, n = 2,551), and old age (≥ 60 years, n = 2,096) groups...
December 2016: Journal of Korean Medical Science
YeonSung Son, BomNaeRin Lee, Young-Jin Choi, Seon Ae Jeon, Ju-Hyun Kim, Hoo-Keun Lee, Sang-Mo Kwon, Je-Yoel Cho
Outgrowth endothelial cells (OECs) are a subpopulation of endothelial progenitor cells (EPCs) that have the capacity for proliferation and the ability to promote angiogenesis. In this study, we identified Nectin-2 as a surface protein of OECs through unbiased quantitative proteomics analysis. Using immunocytochemistry and flow cytometry, we confirmed that Nectin-2 is highly expressed on OECs. Nectin-2 (CD112) expression was limited or lower on mononuclear cells (MNCs) and mature tube-forming endothelial cells (ECs)...
2016: PloS One
Hoo Rim Song, Young-Joon Kwon, Young Sup Woo, Won-Myong Bahk
No abstract text is available yet for this article.
December 2015: Journal of Clinical Psychopharmacology
Sung Han Kim, Sohee Kim, Byung-Ho Nam, Sang Eun Lee, Choung Soo Kim, Ill Young Seo, Tae Nam Kim, Sung-Hoo Hong, Tae Gyun Kwon, Seong Il Seo, Kwan Joong Joo, Kanghyon Song, Cheol Kwak, Jinsoo Chung
OBJECTIVE: To evaluate the efficacy and safety of sorafenib for Korean patients with metastatic renal cell carcinoma (mRCC). METHODS: A total of 177 mRCC patients using sorafenib as first- (N = 116), second- (N = 43), and third-line (N = 18) therapies were enrolled from 11 Korean centers between 2006 and 2012. The patient characteristics, therapy duration, tumor response, disease control rate, and tolerability were assessed at baseline and at routine follow-ups, and the progression-free survival (PFS) and overall survival (OS) times and rates were analyzed...
2015: PloS One
Hoo Rim Song, Won-Myong Bahk, Young Sup Woo, Jong-Hyun Jeong, Young-Joon Kwon, Jeong Seok Seo, Won Kim, Moon-Doo Kim, Young-Chul Shin, Sang-Yeol Lee, Kyung Joon Min
OBJECTIVE: Mirtax is a generic mirtazapine widely used since 2003. We conducted an open-label, uncontrolled 6-week study to evaluate the efficacy and safety of Mirtax for major depressive disorder (MDD). METHODS: Ninety three MDD patients with the diagnosis of MDD and 17-item Hamilton Depression Rating Scale (HDRS) score ≥14 were recruited. The HDRS, Montgomery-Åsberg Depression Rating Scale (MADRS), and the Clinical Global Impressions-Severity Scale (CGI-S) were administered at baseline, 1, 2, 4 and 6 weeks...
August 31, 2015: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
Hoo Rim Song, Young-Joon Kwon, Won-Myong Bahk, Young Sup Woo, Hwang-Bin Lee, Jonghun Lee, Dae-Bo Lee, Sang-Yeol Lee, Moon-Doo Kim, Seunghee Won, Kwanghun Lee, Inki Sohn, Jung Goo Lee, Young-Chul Shin, Sangkeun Chung, Saeheon Jang, Young Myo Jae, Bo-Hyun Yoon
AIMS: We examined prescription patterns in maintenance treatment for recovered bipolar patients and compared these with acute treatments. METHODS: Using retrospective methods, the bipolar patients in clinical recovery (Clinical Global Impression Bipolar Version score ≤ 2 for 6 months) after acute episode were selected. We reviewed differences between prescription patterns at remission and after a maintenance period of at least 6 months. RESULTS: A total of 340 bipolar disorder patients were selected...
January 2016: Psychiatry and Clinical Neurosciences
Young-Won Kim, Won Tae Kim, Seok Joong Yun, Sang-Cheol Lee, Wun-Jae Kim, Yun-Sok Ha, Yong Hyun Park, Seok Ho Kang, Sung-Hoo Hong, Tae Gyun Kwon, Seok-Soo Byun, Cheol Kwak, Yong-June Kim
PURPOSE: Preoperative chronic kidney disease (CKD) status may affect disease outcomes in patients with renal cell carcinoma (RCC). This study evaluated the influence of preoperative CKD status on clinicopathological features and prognosis in patients with RCC. METHODS: Between 1999 and 2011, a total of 1855 patients underwent radical nephrectomy at various centers throughout Korea. Of these patients, 1655 had an estimated glomerular filtration rate (eGFR) ≥60 ml/min/1...
November 2015: Annals of Surgical Oncology
Kunal Singhal, Jemin Kim, Jeffrey Casebolt, Sangwoo Lee, Ki-Hoon Han, Young-Hoo Kwon
Angular momentum of the body is a highly controlled quantity signifying stability, therefore, it is essential to understand its regulation during stair descent. The purpose of this study was to investigate how older adults use gravity and ground reaction force to regulate the angular momentum of the body during stair descent. A total of 28 participants (12 male and 16 female; 68.5 years and 69.0 years of mean age respectively) performed stair descent from a level walk in a step-over-step manner at a self-selected speed over a custom made three-step staircase with embedded force plates...
June 2015: Human Movement Science
Jemin Kim, Margaret A Wilson, Kunal Singhal, Sarah Gamblin, Cha-Young Suh, Young-Hoo Kwon
The purpose of this study was to investigate the vertical angular momentum generation strategies used by skilled ballet dancers in pirouette en dehors. Select kinematic parameters of the pirouette preparation (stance depth, vertical center-of-mass motion range, initial shoulder line position, shoulder line angular displacement, and maximum trunk twist angle) along with vertical angular momentum parameters during the turn (maximum momentums of the whole body and body parts, and duration and rate of generation) were obtained from nine skilled collegiate ballet dancers through a three-dimensional motion analysis and compared among three turn conditions (single, double, and triple)...
September 2014: Sports Biomechanics
Kunal Singhal, Jemin Kim, Jeffrey Casebolt, Sangwoo Lee, Ki Hoon Han, Young-Hoo Kwon
Stair walking is one of the most challenging tasks for older adults, with women reporting higher incidence of falls. The purpose of this study was to investigate the gender differences in kinetics during stair descent transition. Twenty-eight participants (12 male and 16 female; 68.5 and 69.0 years of mean age, respectively) performed stair descent from level walking in a step-over-step manner at a self-selected speed over a custom-made three-step staircase with embedded force plates. Kinematic and force data were combined using inverse dynamics to generate kinetic data for gender comparison...
September 2014: Gait & Posture
Nguyen Phuong Thao, Bui Thi Thuy Luyen, Sung Hoo Jo, Tran Manh Hung, Nguyen Xuan Cuong, Nguyen Hoai Nam, Young In Kwon, Chau Van Minh, Young Ho Kim
Medicinal plants constitute an important source of potential therapeutic agents for diabetes. The purpose of present study is to investigate the effect of root extract of Rosa rugosa Thunb. on inhibition of sucrase related to diabetes mellitus (DM). Bioassay-guided fractionation of the methanol extract led to the identification of 13 triterpenoid saponins (1-13). Their structures were elucidated on the basis of extensive spectroscopic analysis, including 1D, 2D NMR, and MS. The n-butanol fraction showed potent rat intestinal sucrase inhibitory activity with value of 87...
October 2014: Archives of Pharmacal Research
Jeong-Mi Kim, Eun-Mi Noh, Mi-Seong Kim, Jin-Ki Hwang, Hong-Yeon Hwang, Do-Gon Ryu, Hye-Jung Kim, Hong-Nu Yu, Yong-Ouk You, Jong-Suk Kim, Hyun Jo Youn, Kang-Beom Kwon, Sung Hoo Jung, Young-Rae Lee
Decursin, a coumarin compound, was first isolated from the roots of Angelica gigas almost four decades ago. It was found to exhibit cytotoxicity against various human cancer cells and to possess anti-amnesic activity in vivo through the inhibition of AChE activity. However, the effect of decursin on breast cancer invasion is unknown. Matrix metalloproteinase-9 (MMP-9) is known to be an important factor for cancer cell invasion. Therefore, in this study, we investigated the inhibitory effect of decursin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 expression and cell invasion, as well as the molecular mechanisms involved in MCF-7 cells...
May 2014: International Journal of Oncology
Kwang Hyun Ko, Na Young Han, Chang Il Kwon, Hoo Keun Lee, Jong Min Park, Eun Hee Kim, Ki Baik Hahm
Recent advances in optical molecular imaging allow identification of morphologic and biochemical changes in tissues associated with gastrointestinal (GI) premalignant lesions earlier and in real-time. This focused review series introduces high-resolution imaging modalities that are being evaluated preclinically and clinically for the detection of early GI cancers, especially Barrett esophagus and esophageal adenocarcinoma. Although narrow band imaging, autofluorescence imaging, and chromoendoscopy are currently applied for this purpose in the clinic, further adoptions of probe-based confocal laser endomicroscopy, high-resolution microendoscopy, optical coherence tomography, and metabolomic imaging, as well as imaging mass spectrometry, will lead to detection at the earliest and will guide predictions of the clinical course in the near future in a manner that is beyond current advancements in optical imaging...
January 2014: Clinical Endoscopy
Ilhwan Ryu, MinHo Yang, Hyemin Kwon, Hoo Keun Park, Young Rag Do, Sang Bok Lee, Sanggyu Yim
Supercapacitive properties of ruthenium oxide (RuO2) nanoparticles electrodeposited onto the indium tin oxide (ITO) nanopillars were investigated. Compared to conventional planar current collectors, this coaxially nanostructured current collector-electrode system can provide increased contact for efficient charge transport, and the internanopillar spacing allows easy access of electrolyte ions. The morphological and electrochemical properties depended on the thickness of the RuO2 layers, i.e., the number of electrodeposition cycles...
February 18, 2014: Langmuir: the ACS Journal of Surfaces and Colloids
Nguyen Phuong Thao, Bui Thi Thuy Luyen, Bui Huu Tai, Seo Young Yang, Sung Hoo Jo, Nguyen Xuan Cuong, Nguyen Hoai Nam, Young In Kwon, Chau Van Minh, Young Ho Kim
A new octanordammarane triterpene, 3β,15α-dihydroxymansumbinol (1) and a novel A-ring contracted oleanane triterpenoid, 2-formyl-(A)1-19α-hydroxy-1-norolean-2,12-dien-28-oic acid (2) were isolated from the roots extract of Rosa rugosa along with fifteen known compounds (3-17). Their structures were elucidated by extensive spectroscopic analysis, including 1D and 2D NMR, and FTICRMS. The MeOH extract, as well as CH2Cl2 and EtOAc fractions at a concentration of 0.5mg/mL showed potent sucrase inhibitory activity, with inhibition percentage values of 84...
February 15, 2014: Bioorganic & Medicinal Chemistry Letters
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