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https://www.readbyqxmd.com/read/27936454/white-matter-volumes-in-youth-offspring-of-bipolar-parents
#1
Fabiano G Nery, Matthew Norris, James C Eliassen, Wade A Weber, Thomas J Blom, Jeffrey A Welge, Drew A Barzman, Jeffrey R Strawn, Caleb M Adler, Stephen M Strakowski, Melissa P DelBello
BACKGROUND: Studying youth at high risk of developing bipolar disorder may clarify neurobiological factors associated with vulnerability to this illness. We present here a baseline characterization of brain structure in youth at-risk for bipolar disorder. METHODS: Magnetic resonance images were obtained from 115 child and adolescent offspring of bipolar disorder type I subjects and 57 healthy child and adolescent offspring of healthy parents (healthy control offspring)...
November 25, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27936213/radiologic-histopathologic-correlation-of-cerebral-microbleeds-using-pre-mortem-and-post-mortem-mri
#2
Sven Haller, Marie-Louise Montandon, François Lazeyras, Max Scheffler, Stephan Meckel, Francois R Herrmann, Panteleimon Giannakopoulos, Enikö Kövari
INTRODUCTION: Cerebral microbleeds (CMB), also known as cerebral microhemorrhages, are small areas of susceptibility on brain magnetic resonance imaging (MRI), that are increasingly detected due to the higher availability of high-field MRI systems and dedicated pulse sequences. The prevalence of CMBs increases in cases with cognitive decline. The current investigation assessed the poorly investigated radiologic-histopathologic correlation of CMBs on MRI. METHODS: The local ethical committee approved the current investigation...
2016: PloS One
https://www.readbyqxmd.com/read/27936206/abdominal-adiposity-not-cardiorespiratory-fitness-mediates-the-exercise-induced-change-in-insulin-sensitivity-in-older-adults
#3
Gifferd Ko, Lance E Davidson, Andrea M Brennan, Miu Lam, Robert Ross
Abdominal obesity and low cardiorespiratory fitness (CRF) are associated with insulin resistance in older adults. Exercise is associated with improvement in insulin sensitivity. Whether this association is mediated by change in CRF and/or abdominal obesity is unclear. The current study is a secondary analysis of data from a randomized controlled trial in Kingston, Ontario. Sedentary older adults (60-80 years) (N = 80) who completed the exercise (N = 59) or control (N = 21) conditions for 6 months were included...
2016: PloS One
https://www.readbyqxmd.com/read/27936061/in-vivo-measurements-of-t2-relaxation-time-of-mouse-lungs-during-inspiration-and-expiration
#4
Lars E Olsson, Paul D Hockings
PURPOSE: The interest in measurements of magnetic resonance imaging relaxation times, T1, T2, T2*, with intention to characterize healthy and diseased lungs has increased recently. Animal studies play an important role in this context providing models for understanding and linking the measured relaxation time changes to the underlying physiology or disease. The aim of this work was to study how the measured transversal relaxation time (T2) in healthy lungs is affected by normal respiration in mouse...
2016: PloS One
https://www.readbyqxmd.com/read/27936014/inhibition-of-interleukin-6-receptor-in-a-murine-model-of-myocardial-ischemia-reperfusion
#5
Minke H T Hartman, Inge Vreeswijk-Baudoin, Hilde E Groot, Kees W A van de Kolk, Rudolf A de Boer, Irene Mateo Leach, Rozemarijn Vliegenthart, Herman H W Sillje, Pim van der Harst
BACKGROUND: Interleukin-6 (IL-6) levels are upregulated in myocardial infarction. Recent data suggest a causal role of the IL-6 receptor (IL-6R) in coronary heart disease. We evaluated if IL-6R blockade by a monoclonal antibody (MR16-1) prevents the heart from adverse left ventricular remodeling in a mouse model of ischemia-reperfusion (I/R). METHODS: CJ57/BL6 mice underwent I/R injury (left coronary artery ligation for 45 minutes) or sham surgery, and thereafter received MR16-1 (2mg/mouse) 5 minutes before reperfusion and 0...
2016: PloS One
https://www.readbyqxmd.com/read/27935881/-contrast-free-mr-phlebography-as-a-method-of-screening-of-phlebothromboses-and-extravasal-compression-of-the-inferior-vena-cava-and-its-basin
#6
V V Shebryakov, G G Karmazanovsky, Yu M Stoiko, K V Mazaishvili, D K Lyutarevich, S Yu Kim, M V Fel'dsherov, M N Yashkin
The study was aimed at assessing possibilities and determining diagnostic significance of the method of contrast-free magnetic resonance phlebography (MR phlebography) in diagnosis of diseases of the inferior vena cava (IVC) and its basin. Presented herein is experience with examining a total of 74 patients at two therapeutic-diagnostic facilities: the National Medical Surgical Centre named after N.I. Pirogov and the Medical Diagnostic Centre "Ramsey Diagnostics". The studies were carried out on magnetic resonance tomographs "Philips Intera Nova" and "GE Optima MR360", using a special protocol of contrast-free MR-phlebography in consequences at free breathing, followed by 3D reconstruction and processing of the obtained images as MIP and 3D...
2016: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/27935825/microglia-activation-in-a-pediatric-rabbit-model-of-tuberculous-meningitis
#7
Elizabeth W Tucker, Supriya Pokkali, Zhi Zhang, Vincent P DeMarco, Mariah Klunk, Elizabeth S Smith, Alvaro A Ordonez, Marie-France Penet, Zaver Bhujwalla, Sanjay K Jain, Sujatha Kannan
Central nervous system (CNS) tuberculosis (TB) is the most severe form of extra-pulmonary TB and disproportionately affects young children where the developing brain has a unique host response. New Zealand white rabbits were infected with Mycobacterium tuberculosis via subarachnoid inoculation at postnatal day 4-8 and evaluated until 4-6 weeks post-infection. Control and infected rabbit kits were assessed for the development of neurological deficits, bacterial burden, and postmortem microbiologic and pathologic changes...
December 1, 2016: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/27935768/hypertrophic-osteoarthropathy-clinical-and-imaging-features
#8
Felix Y Yap, Matthew R Skalski, Dakshesh B Patel, Aaron J Schein, Eric A White, Anderanik Tomasian, Sulabha Masih, George R Matcuk
Hypertrophic osteoarthropathy (HOA) is a medical condition characterized by abnormal proliferation of skin and periosteal tissues involving the extremities and characterized by three clinical features: digital clubbing (also termed Hippocratic fingers), periostosis of tubular bones, and synovial effusions. HOA can be a primary entity, known as pachydermoperiostosis, or can be secondary to extraskeletal conditions, with different prognoses and management implications for each. There is a high association between secondary HOA and malignancy, especially non-small cell lung cancer...
December 9, 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27935600/pseudodacryocystitis-paediatric-case-series-of-infected-atypical-ethmoid-air-cells-masquerading-as-recurrent-dacryocystitis
#9
A Mohite, T Jenyon, B Manoj, S Sandramouli, K Foster, A Oates, A-L McDermott, M V Parulekar
PurposeTo highlight the clinical and surgical considerations in treating patients with apparent recurrent acute dacryocystitis with a patent lacrimal system.MethodsThree children referred to a tertiary unit as recurrent acute dacryocystitis were reviewed retrospectively. Imaging and subsequent surgical intervention revealed the underlying diagnosis.ResultsAll three cases presented with recurrent abscesses in the region of the lacrimal sac that failed to respond to incision and drainage. The lesions were lower and more lateral to the usual location of a sac abscess and closer to the inferior orbital rim...
December 9, 2016: Eye
https://www.readbyqxmd.com/read/27935599/magnetic-resonance-imaging-of-the-functional-anatomy-of-the-superior-oblique-muscle-in-patients-with-primary-superior-oblique-overaction
#10
Q Gong, M Janowski, H Tang, Q Yang, H Wei, X Zhou, L Liu
PurposeTo quantitatively determine the size and contractility of the superior oblique (SO) muscle in primary SO overaction (PSOOA).Patients and methodsA prospective, observational study was conducted on 12 patients with PSOOA, and 10 healthy, orthotropic subjects. Sets of contiguous, 2 mm slice thickness, quasi-coronal magnetic resonance imaging were obtained during different gazes, giving pixel resolution of 0.391 mm. Cross-sectional areas of the SO muscles were determined in primary position, supraduction, and infraduction to evaluate size and contractility...
December 9, 2016: Eye
https://www.readbyqxmd.com/read/27935574/europium-doping-of-superparamagnetic-iron-oxide-nanoparticles-enables-their-detection-by-fluorescence-microscopy-and-for-quantitative-analytics
#11
Yuske Kobayashi, Ralf Hauptmann, Harald Kratz, Monika Ebert, Susanne Wagner, Matthias Taupitz
BACKGROUND: Pharmacokinetic studies and histological detection of superparamagnetic iron oxide nanoparticles (SPIO) in biomedical research are limited due to a high iron background especially in pathological tissues. OBJECTIVE: The suitability of doping the iron oxide cores of SPIO with europium (Eu) was tested for improved histologic detection and for quantitative analysis without changing their properties as probes for magnetic resonance imaging (MRI). A special variant of SPIO, so called very small superparamagnetic iron oxide nanoparticles (VSOP), was used for this approach...
December 2, 2016: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/27935543/acoustic-neuroma-as-first-sign-of-inner-ear-functional-disorders
#12
Marzena Bielińska, Kalina Owczarek, Joanna Nowosielska-Grygiel, Jurek Olszewski, Piotr Pietkiewicz
INTRODUCTION: The aim of this work was to describe acoustic neuromas as the first signs of inner ear functional disorders. MATERIAL AND METHODS: The study covered 3,456 audiological and otoneurological patients, who were treated in the Department of Otolaryngology, Laryngological Oncology, Audiology and Phoniatrics Military Medical Academy University Teaching Hospital in Lodz within the period of 2011-2016. Among the studied subjects, an acoustic neuroma on the vestibulocochlear nerve was diagnosed in 13 cases (5,16%), including 9 women and 4 men...
October 31, 2016: Otolaryngologia Polska. the Polish Otolaryngology
https://www.readbyqxmd.com/read/27935229/cortico-limbic-connectivity-in-maoa-l-carriers-is-vulnerable-to-acute-tryptophan-depletion
#13
Patrick Eisner, Martin Klasen, Dhana Wolf, Klaus Zerres, Thomas Eggermann, Albrecht Eisert, Mikhail Zvyagintsev, Pegah Sarkheil, Krystyna A Mathiak, Florian Zepf, Klaus Mathiak
INTRODUCTION: A gene-environment interaction between expression genotypes of the monoamine oxidase A (MAOA) and adverse childhood experience increases the risk of antisocial behavior. However, the neural underpinnings of this interaction remain uninvestigated. A cortico-limbic circuit involving the prefrontal cortex (PFC) and the amygdala is central to the suppression of aggressive impulses and is modulated by serotonin (5-HT). MAOA genotypes may modulate the vulnerability of this circuit and increase the risk for emotion regulation deficits after specific life events...
December 9, 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/27935100/precise-injection-of-human-mesenchymal-stromal-cells-in-the-urethral-sphincter-complex-of-g%C3%A3-ttingen-minipigs-without-unspecific-bulking-effects
#14
Bastian Amend, Alexandra Kelp, Martin Vaegler, Mario Klünder, Viktoria Frajs, Gerd Klein, Karl-Dietrich Sievert, Oliver Sawodny, Arnulf Stenzl, Wilhelm K Aicher
AIM: To investigate if injection of cells in the urethral sphincter complex causes unspecific bulking effects. METHODS: Human mesenchymal stromal cells were isolated, expanded, and characterized. For transurethral injection, cells were labeled with the fluorescent dye PKH26 and in magnetic resonance imaging associated experiments with superparamagnetic particles. Aliquots of cells in 250 µL solvent were injected under vision in the urethral sphincter of immuno-suppressed Göttingen minipigs...
December 9, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27934890/plasmonic-efficiencies-of-nanoparticles-made-of-metal-nitrides-tin-zrn-compared-with-gold
#15
Adrien Lalisse, Gilles Tessier, Jérome Plain, Guillaume Baffou
Metal nitrides have been proposed to replace noble metals in plasmonics for some specific applications. In particular, while titanium nitride (TiN) and zirconium nitride (ZrN) possess localized plasmon resonances very similar to gold in magnitude and wavelength, they benefit from a much higher sustainability to temperature. For this reason, they are foreseen as ideal candidates for applications in nanoplasmonics that require high material temperature under operation, such as heat assisted magnetic recording (HAMR) or thermophotovoltaics...
December 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27934635/metabolism-of-the-mek1-2-inhibitor-pimasertib-involves-a-novel-conjugation-with-phospho-ethanolamine-in-patients-with-solid-tumors
#16
Holger Scheible, Friedrich Kraetzer, Andreas Marx, Andreas Johne, Elmar Wimmer
Pimasertib (AS703026 or MSC1936369B) is a selective inhibitor of MEK1/2, the mitogen-activated protein kinase (MAPK) signaling pathway, which is often dysregulated in cancer cells. Pimasertib has shown potent preclinical anti tumor activity and its clinical activity is being investigated in various tumor types. In this phase I study, the disposition and biotransformation of (14)C-radiolabeled pimasertib was investigated in six patients with locally advanced or metastatic solid tumors (NCT 01713036). Ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) and radiodetection techniques were used to investigate the profiles and structures of metabolites in plasma, urine and feces after a single oral dose of (14)C-pimasertib...
December 1, 2016: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/27934631/cardiac-involvement-in-ankylosing-spondylitis-can-new-magnetic-resonance-indices-interpret-cardiac-pathophysiology-beyond-echocardiography
#17
EDITORIAL
Sophie Mavrogeni, Genovefa Kolovou, George Kitas
No abstract text is available yet for this article.
December 1, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27934188/nanostructured-montmorillonite-clay-for-controlling-the-lipase-mediated-digestion-of-medium-chain-triglycerides
#18
Tahnee J Dening, Paul Joyce, Shasha Rao, Nicky Thomas, Clive A Prestidge
Biocompatible lipid hybrid particles composed of montmorillonite and medium chain triglycerides were engineered for the first time by spray drying oil-in-water emulsions stabilized by montmorillonite platelets to form montmorillonite-lipid hybrid (MLH) microparticles containing up to 75% w/w lipid. In vitro lipolysis studies under simulated intestinal conditions indicated that the specific porous nanoarchitecture and surface chemistry of MLH particles significantly increased the rate (>10-fold) and extent of lipase-mediated digestion compared to that of coarse and homogenized submicrometer triglyceride emulsions...
December 7, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27934159/tailored-dual-pegylation-of-inorganic-porous-nanocarriers-for-extremely-long-blood-circulation-in-vivo
#19
Tuomo Nissinen, Simo Näkki, Hanne Laakso, Dalius Kučiauskas, Algirdas Kaupinis, Mikko I Kettunen, Timo Liimatainen, Mervi Hyvönen, Mindaugas Valius, Olli Gröhn, Vesa-Pekka Lehto
Drug carrier systems based on mesoporous inorganic nanoparticles generally face the problem of fast clearance from bloodstream thus failing in passive and active targeting to cancer tissue. To address this problem, a specific dual PEGylation (DPEG) method for mesoporous silicon (PSi) was developed and studied in vitro and in vivo. The DPEG coating changed significantly the behavior of the nanoparticles in vivo, increasing the circulation half-life from 1 to 241 min. Furthermore, accumulation of the coated particles was mainly taking place in the spleen whereas uncoated nanoparticles were rapidly deposited in the liver...
December 7, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27934124/detection-of-moisture-by-fluorescent-off-on-sensor-in-organic-solvents-and-raw-food-products
#20
Pawan Kumar, Rahul Kaushik, Amrita Ghosh, D Amilan Jose
Copper complex based on a new class of fluorescence OFF-ON sensor 1.Cu has been reported for the detection of trace amounts of water in various organic solvents such as CH3OH, THF, CH3CN, and acetone by means of fluorescence emission intensity. The probe is highly responsive to water in THF (DL = 0.003 wt %). The dissociation of copper from probe 1.Cu in the presence of water is responsible for the fluorescence change and it was confirmed by electrospray ionization-mass spectrometry (ESI-MS), proton nuclear magnetic resonance ((1)H-NMR), and fluorescence lifetime studies...
December 6, 2016: Analytical Chemistry
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