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https://www.readbyqxmd.com/read/28445420/vitamin-d-and-calcium-are-required-during-denosumab-treatment-in-osteoporosis-with-rheumatoid-arthritis
#1
Yukio Nakamura, Takako Suzuki, Tomohiko Yoshida, Hideshi Yamazaki, Hiroyuki Kato
The aim of this 12-month retrospective study was to evaluate differences in the outcomes of denosumab alone or denosumab combined with vitamin D and calcium supplementation in patients having osteoporosis (OP) with rheumatoid arthritis (RA). Patients were divided into the denosumab monotherapy group (denosumab group, 22 cases) or denosumab plus vitamin D supplementation group (combination group, 21 cases). We measured serum bone alkaline phosphatase (BAP), N-terminal propeptide of type 1 collagen (P1NP), tartrate-resistant acid phosphatase (TRACP)-5b, and urinary N-terminal telopeptide of type-I collagen (NTX) at baseline, 1 week, and 1, 2, 4, 6, 8, and 12 months...
April 26, 2017: Nutrients
https://www.readbyqxmd.com/read/28445258/renal-vascular-calcification-and-response-to-renal-nerve-denervation-in-resistant-hypertension
#2
Annemiek F Hoogerwaard, Mark R de Jong, Ahmet Adiyaman, Jaap Jan J Smit, Peter P H M Delnoy, Jan-Evert Heeg, Boudewijn A A M van Hasselt, Anand R Ramdat Misier, Arif Elvan
Renal sympathetic nerve denervation (RDN) is accepted as a treatment option for patients with resistant hypertension. However, results on decline in ambulatory blood pressure (BP) measurement (ABPM) are conflicting. The high rate of nonresponders may be related to increased systemic vascular stiffness rather than sympathetic overdrive. A single center, prospective registry including 26 patients with treatment resistant hypertension who underwent RDN at the Isala Hospital in the Netherlands. Renal perivascular calcium scores were obtained from noncontrast computed tomography scans...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28444996/breast-arterial-calcification-association-with-coronary-artery-calcium-scoring-and-implications-for-cardiovascular-risk-assessment-in-women
#3
REVIEW
Angela J Ryan, Andrew D Choi, Brian G Choi, Jannet F Lewis
Breast arterial calcification (BAC) is a type of medial artery calcification that can be seen incidentally on mammography. Studies have suggested association of BAC with cardiovascular risk factors, coronary artery disease (CAD), and cardiovascular morbidity and mortality. Recently published studies have also suggested a modest correlation of BAC with coronary artery calcium (CAC) scoring. Roughly 40 million mammograms are already performed annually in the United States with overlap in patients that undergo CAD screening via CAC scoring...
April 26, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28443950/chronic-kidney-disease-determinants-of-progression-and-cardiovascular-risk-progredir-cohort-study-design-and-methods
#4
Maria Alice Muniz Domingos, Alessandra Carvalho Goulart, Paulo Andrade Lotufo, Isabela Judith Martins Benseñor, Silvia Maria de Oliveira Titan
CONTEXT AND OBJECTIVE: Chronic kidney disease (CKD) has become an important public health issue. The socioeconomic burden of renal replacement therapy (RRT) is very high, as is CKD-related cardiovascular mortality and morbidity. Preventive and therapeutic measures only have modest impact and more research is needed. Few cohort studies have been conducted on populations with CKD. Our aim was to establish a cohort that would include more advanced forms of CKD (stages 3 and 4). Data collection was focused on renal and cardiovascular parameters...
April 20, 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28442927/mechanical-factors-and-vitamin-d-deficiency-in-schoolchildren-with-low-back-pain-biochemical-and-cross-sectional-survey-analysis
#5
Ahmad H Alghadir, Sami A Gabr, Einas S Al-Eisa
OBJECTIVE: This study was designed to evaluate the role of vitamin D, muscle fatigue biomarkers, and mechanical factors in the progression of low back pain (LBP) in schoolchildren. BACKGROUND: Children and adolescents frequently suffer from LBP with no clear clinical causes, and >71% of schoolchildren aged 12-17 years will show at least one episode of LBP. MATERIALS AND METHODS: A total of 250 schoolchildren aged 12-16 years were randomly enrolled in this study...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28437620/american-association-of-clinical-endocrinologists-and-american-college-of-endocrinology-guidelines-for-management-of-dyslipidemia-and-prevention-of-cardiovascular-disease
#6
Paul S Jellinger, Yehuda Handelsman, Paul D Rosenblit, Zachary T Bloomgarden, Vivian A Fonseca, Alan J Garber, George Grunberger, Chris K Guerin, David S H Bell, Jeffrey I Mechanick, Rachel Pessah-Pollack, Kathleen Wyne, Donald Smith, Eliot A Brinton, Sergio Fazio, Michael Davidson
OBJECTIVE: The development of these guidelines is mandated by the American Association of Clinical Endocrinologists (AACE) Board of Directors and American College of Endocrinology (ACE) Board of Trustees and adheres with published AACE protocols for the standardized production of clinical practice guidelines (CPGs). METHODS: Recommendations are based on diligent reviews of the clinical evidence with transparent incorporation of subjective factors, according to established AACE/ACE guidelines for guidelines protocols...
April 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28437443/relative-predictive-value-of-lung-cancer-screening-ct-versus-myocardial-perfusion-attenuation-correction-ct-in-the-evaluation-of-coronary-calcium
#7
Grant Bailey, Abigail Healy, Bryan D Young, Esseim Sharma, Judith Meadows, Hyung J Chun, Wen-Chih Wu, Gaurav Choudhary, Alan R Morrison
Coronary artery calcium scores (CACS) from lung cancer screening computed tomography (LCSCT) or myocardial perfusion attenuation correction computed tomography (ACCT) are not routinely performed or reported. CACS from LCSCT and ACCT have not been directly compared in the same patient population. We identified 66 patients who underwent both LCSCT (non-gated) and ECG-gated cardiac CT (CCT) within a 2-year span. Of this population, 40 subjects had also undergone ACCT. Using the Agatston method, CACS for 264 individual vessels from the LCSCT population and for 160 vessels from ACCT population were calculated and evaluated for agreement with ECG-gated CCT as the gold standard...
2017: PloS One
https://www.readbyqxmd.com/read/28435446/cardiovascular-risk-assessment-in-patients-with-diabetes
#8
REVIEW
Marcello Casaccia Bertoluci, Viviane Zorzanelli Rocha
Although patients with diabetes have 2 to 4 times increased risk of cardiovascular morbidity and mortality than individuals without diabetes, recent studies indicate that a significant part of patients are in a lower cardiovascular risk category. Men younger than 35 years, women younger than 45 years, patients with diabetes duration of less than 10 years without other risk factors have a much lower risk than patients who have traditional cardiovascular risk factors, and subclinical or established coronary artery disease (CAD)...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28434191/the-effect-of-parotid-gland-sparing-imrt-on-salivary-composition-flow-rate-and-xerostomia-measures
#9
Thomas M Richards, Tara Hurley, Lorna Grove, Kevin J Harrington, Guy H Carpenter, Gordon B Proctor, Christopher M Nutting
OBJECTIVES: To describe parotid gland (PG) saliva organic and inorganic composition and flow rate changes, after curative intensity-modulated radiotherapy (IMRT) for head and neck cancer (HNC) and analyse the relationship between PG saliva analytes and xerostomia measures. METHODS AND MATERIALS: Twenty-six patients recruited to five prospective phase 2 or 3 trials which assessed toxicity and efficacy of IMRT by HNC subsite, provided longitudinal PG salivas. Salivary flow rate, subjective and objective xerostomia measures were prospectively collected and salivas tested for inorganic and organic analytes...
April 23, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28431628/clinical-and-quantitative-analysis-of-patients-with-crowned-dens-syndrome
#10
Teruyuki Takahashi, Masato Tamura, Toshiaki Takasu, Satoshi Kamei
BACKGROUND: Crowned dens syndrome (CDS) is a radioclinical entity defined by calcium deposition on the transverse ligament of atlas (TLA). In this study, the novel semi-quantitative diagnostic criteria for CDS to evaluate the degree of calcification on TLA by cervical CT are proposed. METHOD: From January 2010 to September 2014, 35 patients who were diagnosed with CDS by cervical CT were adopted as subjects in this study. Based on novel criteria, calcium deposition on TLA was classified into "Stage" and "Grade", to make a score, which was evaluated semi-quantitatively...
May 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28429533/impact-of-adverse-drug-events-and-treatment-satisfaction-on-patient-adherence-with-antihypertensive-medication-a-study-in-ambulatory-patients
#11
Derbew Fikadu Berhe, Katja Taxis, Flora M Haaijer-Ruskamp, Afework Mulugeta, Yewondwossen Tadesse Mengistu, Johannes G M Burgerhof, Peter G M Mol
OBJECTIVE: To evaluate the impact of adverse drug events (ADEs) and treatment satisfaction on antihypertensive medication adherence. METHODS: A cross-sectional study was conducted in six public hospitals in Ethiopia. We included adult ambulatory patients on antihypertensive medication. Adherence was measured with the 8-point Morisky Medication Adherence Scale (MMAS-8), categorized in low (0-5), medium (6-7), and high (=8) adherence. Treatment satisfaction was measured using the Treatment Satisfaction Questionnaire for Medication (TSQM) version 1...
April 21, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28427885/prognostic-scoring-system-to-risk-stratify-parathyroid-carcinoma
#12
Angelica M Silva-Figueroa, Kenneth R Hess, Michelle D Williams, Callisia N Clarke, Ioannis Christakis, Paul H Graham, Elizabeth G Grubbs, Jeffrey E Lee, Naifa L Busaidy, Nancy D Perrier
BACKGROUND: Parathyroid carcinoma is a rare endocrine malignancy that lacks an established system for risk categorization. This study evaluated a prognostic scoring system for recurrence-free survival (RFS) of patients with parathyroid carcinoma. STUDY DESIGN: Patients diagnosed and confirmed to have parathyroid carcinoma and who were treated between 1980 and 2016 at The University of Texas MD Anderson Cancer Center were studied retrospectively. Univariate and multivariate Cox proportional hazards regression analyses of RFS were conducted...
March 15, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28427294/increased-phagocytic-nadph-oxidase-activity-associates-with-coronary-artery-calcification-in-asymptomatic-men
#13
Oscar Beloqui, María U Moreno, Gorka San José, Álvaro Pejenaute, Adriana Cortés, Manuel F Landecho, Javier Díez, Ana Fortuño, Guillermo Zalba
Vascular calcification is a common feature in atherosclerosis and associates with cardiovascular events. Oxidative stress may be involved in the pathogenesis of vascular calcification. Previous studies have shown that the phagocytic NADPH oxidase is associated with atherosclerosis. The objective of the present study was to investigate the association between phagocytic NADPH oxidase-mediated superoxide production and coronary artery calcium (CAC). NADPH oxidase-mediated superoxide production was determined by chemiluminescence and CAC by computed tomography in 159 asymptomatic men free of overt clinical atherosclerosis...
April 20, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28427257/effect-of-dietary-calcium-concentrations-in-low-non-phytate-phosphorus-diets-containing-phytase-on-growth-performance-bone-mineralization-litter-quality-and-footpad-dermatitis-incidence-in-growing-broiler-chickens
#14
Jong Hyuk Kim, Hyunjung Jung, Franco Martinez Pitargue, Gi Ppeum Han, Hyeon Seok Choi, Dong Yong Kil
Objective: An experiment was conducted to investigate the effect of dietary Ca concentrations in low non-phytate phosphorus (NPP) diets containing phytase on growth performance, bone mineralization, litter quality, and footpad dermatitis (FPD) incidence in growing broiler chickens. Methods: A total of 1,800 21-day-old Ross 308 growing broiler chickens were allotted to 1 of 6 dietary treatments with 6 replicated cages. Six diets were formulated to provide increasing Ca concentrations of 4...
April 21, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28426828/consumption-of-fortified-infant-foods-reduces-dietary-diversity-but-has-a-positive-effect-on-subsequent-growth-in-infants-from-sumedang-district-indonesia
#15
Aly Diana, Simonette R Mallard, Jillian J Haszard, Dwi Monik Purnamasari, Ikrimah Nurulazmi, Pratami D Herliani, Gaga I Nugraha, Rosalind S Gibson, Lisa Houghton
Stunting and underweight among under-five children in Indonesia are common, raising public health concerns. Whether inappropriate complementary feeding (CF) practices compromise optimal growth during late infancy in Indonesia is uncertain. Therefore we characterized and evaluated CF practices in Indonesian infants and investigated their relationship with subsequent growth. We enrolled breastfed infants at 6 months of age (n = 230); and followed them at 9 (n = 202) and 12 months of age (n = 190). We collected socio-demographic and anthropometric data and two-day in-home weighed food records...
2017: PloS One
https://www.readbyqxmd.com/read/28418600/validation-of-a-laboratory-developed-test-of-human-sperm-capacitation
#16
Melissa A Moody, Cristina Cardona, Alana J Simpson, T Timothy Smith, Alexander J Travis, G Charles Ostermeier
Sperm must undergo capacitation to become fertilization competent. Here we validated that monosialotetrahexosylganglioside (GM1 ) localization patterns, which were assessed in the Cap-Score™ Sperm Function Test, reflect a capacitated state in human sperm. First, we defined patterns representing sperm that do or do not respond to stimuli for capacitation. Sperm with "capacitated" patterns had exposed acrosomal carbohydrates and underwent acrosome exocytosis in response to calcium ionophore (A23187). Precision was evaluated by percent change of the Cap-Score measured for 50, 100, 150, and 200 sperm...
April 18, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28418321/s100a10-identified-in-a-genome-wide-gene-%C3%A3-cannabis-dependence-interaction-analysis-of-risky-sexual-behaviours
#17
Renato Polimanti, Shashwath A Meda, Godfrey D Pearlson, Hongyu Zhao, Richard Sherva, Lindsay A Farrer, Henry R Kranzler, Joel Gelernter
BACKGROUND: We conducted a genome-wide gene × environment interaction analysis to identify genetic variants that interact with cannabis dependence (CaD) in influencing risky sexual behaviours (RSB). METHODS: Our sample included cannabis-exposed and sexually experienced African-American and European-American participants. A DSM-IV CaD diagnosis and RSB were evaluated using the Semi-Structured Assessment for Drug Dependence and Alcoholism. We analyzed RSBs as a score that takes into account experiences of unprotected sex and multiple sexual partners...
April 13, 2017: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/28417148/relationship-between-nutritional-factors-and-hip-bone-density-in-individuals-with-chronic-stroke
#18
Samuel K Y Li, Mabel M P Wan, Frankie P L Siu, Susan Chung, Marco Y C Pang
The aim of this study was to investigate the relationship between dietary habits and hip bone health in community-dwelling individuals with chronic stroke. The usual dietary intake of 94 individuals with chronic stroke (30 women, mean age: 59.0 years) was assessed by a 3-day food record within a single week. Dual-energy X-ray absorptiometry was used to measure bone mineral density (BMD) at both hips. The results showed that low hip bone mass was found in 59 and 50 of the participants on the affected and unaffected side, respectively...
April 17, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28416363/-adequacy-of-treatment-for-osteoporosis-in-primary-prevention-quantitative-and-qualitative-study
#19
Cristina Vedia Urgell, Mireia Massot Mesquida, Roser Valles Fernandez, Juan Antonio Garcia Vicente, Alicia Franzi Siso, Laura Muñoz Ortiz, Laia Vilaró Jaques, Maite Bosch Peligero
OBJECTIVE: Quantitative study: To assess the prevalence of inadequacy of treatment for osteoporosis in primary prevention (OPP) in women aged 60-74years. Qualitative study: To evaluate the diagnostic and treatment criteria of the OPP and it's variability in primary care physicians (PC) and specialists. MATERIAL AND METHODS: Quantitative study: observational, cross-sectional and retrospective study. POPULATION: women aged 60-74years with active treatment for OPP (n=424) in May 2012...
April 14, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28414758/early-dialysis-initiation-does-not-improve-clinical-outcomes-in-elderly-end-stage-renal-disease-patients-a-multicenter-prospective-cohort-study
#20
MULTICENTER STUDY
Jae Yoon Park, Kyung Don Yoo, Yong Chul Kim, Dong Ki Kim, Kwon Wook Joo, Shin-Wook Kang, Chul Woo Yang, Nam-Ho Kim, Yong-Lim Kim, Chun-Soo Lim, Yon Su Kim, Jung Pyo Lee
BACKGROUND: The optimal timing for initiating dialysis in end-stage renal disease (ESRD) is controversial, especially in the elderly. METHODS: 665 patients ≥65 years old who began dialysis from August 2008 to February 2015 were prospectively enrolled in the Clinical Research Center for End-Stage Renal Disease cohort study. Participants were divided into 2 groups based on the median estimated glomerular filtration rate at the initiation of dialysis. Propensity score matching (PSM) was used to compare the overall survival rate, cardiovascular events, Kidney Disease Quality of Life Short Form 36 (KDQOL-36) results, Karnofsky performance scale values, Beck's depression inventory values, and subjective global assessments...
2017: PloS One
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