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https://www.readbyqxmd.com/read/29457371/validation-of-a-blood-marker-for-plasma-volume-in-endurance-athletes-during-a-live-high-train-low-altitude-training-camp
#1
Louisa M Lobigs, Laura A Garvican-Lewis, Victor L Vuong, Nicolin Tee, Christopher J Gore, Peter Peeling, Brian Dawson, Yorck O Schumacher
Altitude is a confounding factor within the Athlete's Biological Passport (ABP) due, in part, to the plasma volume (PV) response to hypoxia. Here, a newly developed PV blood test is applied to assess the possible efficacy of reducing the influence of PV on the volumetric ABP markers; hemoglobin concentration ([Hb]) and the OFF-score. Endurance athletes (n=34) completed a 21 night simulated live high: train low protocol (14h.d-1 at 3000m). Bloods were collected twice pre-altitude, at days 3, 8 and 15 at altitude and 1, 7, 21 and 42 days post-altitude...
February 19, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29454784/coronary-artery-calcium-scores-and-atherosclerotic-cardiovascular-disease-risk-stratification-in-smokers-mesa
#2
Adam Leigh, John W McEvoy, Parveen Garg, J Jeffrey Carr, Veit Sandfort, Elizabeth C Oelsner, Matthew Budoff, David Herrington, Joseph Yeboah
OBJECTIVES: This study assessed the utility of the pooled cohort equation (PCE) and/or coronary artery calcium (CAC) for atherosclerotic cardiovascular disease (ASCVD) risk assessment in smokers, especially those who were lung cancer screening eligible (LCSE). BACKGROUND: The U.S. Preventive Services Task Force recommended and the Centers for Medicare & Medicaid Services currently pays for annual screening for lung cancer with low-dose computed tomography scans in a specified group of cigarette smokers...
February 9, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29454767/diagnostic-performance-of-fully-automated-pixel-wise-quantitative-myocardial-perfusion-imaging-by-cardiovascular-magnetic-resonance
#3
Li-Yueh Hsu, Matthew Jacobs, Mitchel Benovoy, Allison D Ta, Hannah M Conn, Susanne Winkler, Anders M Greve, Marcus Y Chen, Sujata M Shanbhag, W Patricia Bandettini, Andrew E Arai
OBJECTIVES: The authors developed a fully automated framework to quantify myocardial blood flow (MBF) from contrast-enhanced cardiac magnetic resonance (CMR) perfusion imaging and evaluated its diagnostic performance in patients. BACKGROUND: Fully quantitative CMR perfusion pixel maps were previously validated with microsphere MBF measurements and showed potential in clinical applications, but the methods required laborious manual processes and were excessively time-consuming...
February 9, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29454686/differential-effects-of-a-single-dose-of-oral-calcium-based-on-postpartum-plasma-calcium-concentration-in-holstein-cows
#4
B M Leno, R C Neves, I M Louge, M D Curler, M J Thomas, T R Overton, J A A McArt
Our objectives were to determine (1) the effect of a single dose of an oral Ca bolus within 24 h after parturition on plasma Ca concentration, (2) the response of primiparous (PP) and multiparous (MP) cows to this supplementation strategy, and (3) differential responses based on plasma Ca at enrollment. For objective 1, cows from 1 commercial dairy in New York State were enrolled within 19 h after parturition (mean ± standard deviation = 8.3 ± 5.3 h) and randomized within parity group (first, second, and ≥third) to control [CON (n = 25); no placebo] or a single dose bolus treatment [BOL (n = 25); 3 oral Ca boluses supplying 54 to 64 g of Ca]...
February 14, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29452691/recurrent-cardiovascular-events-in-survivors-of-myocardial-infarction-with-st-segment-elevation-from-the-ami-quebec-study
#5
Thao Huynh, Martine Montigny, Umair Iftikhar, Roxanne Gagnon, Mark Eisenberg, Claude Lauzon, Samer Mansour, Stephane Rinfret, Marc Afilalo, Michel Nguyen, Simon Kouz, Jean-Pierre Déry, Richard Harvey, Robert De LaRocheliere, Bernard Cantin, Eerick Schampaert, Jean-Claude Tardif
The characteristics and predictors of long-term recurrent ischemic cardiovascular events (RICEs) after myocardial infarction with ST-segment elevation (STEMI) have not yet been clarified. We aimed to characterize the 10-year incidence, types, and predictors of RICE. We obtained 10-year follow-up of STEMI survivors at 17 Quebec hospitals in Canada (the AMI-QUEBEC Study) in 2003. There were 858 patients; mean age was 60 years and 73% were male. The majority of patients receive reperfusion therapy; 53.3% and 39...
January 31, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29452689/measurements-of-lumen-areas-and-diameters-of-proximal-and-middle-coronary-artery-segments-in-subjects-without-coronary-atherosclerosis
#6
Jaroslaw Skowronski, Jerzy Pregowski, Gary S Mintz, Mariusz Kruk, Cezary Kepka, Pawel Tyczynski, Ilona Michalowska, Lukasz Kalinczuk, Maksymilian P Opolski, Michal Ciszewski, Rafal Wolny, Zbigniew Chmielak, Adam Witkowski
There are plenty of data on morphology and lumen dimensions of diseased coronary arteries. However, information on normal coronary vessel anatomy is scarce. We provided computed tomography angiography-derived reference values of lumen dimensions in proximal and middle coronary segments in a healthy population with respect to gender and vessel dominance. Consecutive 2,849 computed tomography angiography examinations were reviewed to identify 201 subjects (77 men, patient age 50 ± 13 years) whose coronary arteries were free from any sign of atherosclerosis (calcium score 0, no detectable plaque)...
February 2, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29451618/the-association-of-vitamin-d-levels-and-the-frailty-phenotype-among-non-geriatric-dialysis-patients-a-cross-sectional-study
#7
Demet Tekdos Demircioglu
OBJECTIVES: The aim of this study was to investigate the frequency of frailty and the association of vitamin D levels and the frailty phenotype among non-geriatric dialysis patients. METHOD: Seventy-four stable, chronic hemodialysis patients from the hemodialysis unit of the hospital were enrolled in the study. The patients' medical histories and laboratory findings were obtained from the medical records of the dialysis unit. Serum parathyroid hormone and 25-hydroxy vitamin D levels were determined using chemiluminometric immunoassays...
2018: Clinics
https://www.readbyqxmd.com/read/29450584/dietary-patterns-and-longitudinal-change-in-hip-bone-mineral-density-among-older-men
#8
T S Rogers, S Harrison, S Judd, E S Orwoll, L M Marshall, J Shannon, L Langsetmo, N E Lane, J M Shikany
Studying dietary patterns is often more informative than individual nutrients or foods. We found that a Prudent dietary pattern (rich in vegetables and fish) was associated with reduced loss of total hip BMD in older men. A Prudent dietary pattern may be a potential lifestyle strategy for minimizing bone loss. INTRODUCTION: This study aimed to identify baseline dietary patterns using factor analysis in a cohort of older men and to evaluate whether the dietary patterns were associated with bone mineral density change (%ΔBMD) at the total hip and femoral neck over time...
February 15, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29445220/association-of-admission-serum-levels-of-vitamin-d-calcium-phosphate-magnesium-and-parathormone-with-clinical-outcomes-in-neurosurgical-icu-patients
#9
Seyed Hossein Ardehali, Salman Dehghan, Ahmad Reza Baghestani, Aynaz Velayati, Zahra Vahdat Shariatpanahi
To evaluate the association of admission serum levels of 25(OH)D, parathormone and the related electrolytes with severity of illness and clinical outcomes in neurosurgical critically ill patients, serum levels of 25(OH)D, parathormone, calcium, magnesium, and phosphate, along with APACHE II score were measured for 210 patients upon admission. Mean serum 25(OH)D was 21.1 ± 7.4 ng/mL. 25(OH)D deficiency (less than 20 ng/dL) and elevated serum parathormone level were found in 47.6% and 38% of patients respectively...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29443744/serum-levels-of-vitamin-a-and-25-hydroxyvitamin-d3-25ohd3-as-reflectors-of-pulmonary-function-and-quality-of-life-qol-in-children-with-stable-asthma-a-case-control-study
#10
Ya-Jie Bai, Ru-Jun Dai
BACKGROUND: This study aims to explore the relationship between serum vitamin A and 25-hydroxyvitamin D3 (25OHD3) levels with pulmonary function and quality of life (QOL) in children with stable asthma. METHODS: A total of 117 cases of children with stable asthma were assigned into the case group and 129 healthy children underwent physical examination during the same period into the control group. Electrochemiluminescence was employed to determine serum vitamin A and 25OHD3 levels...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29440877/psychometric-properties-and-assessment-of-the-osteoporosis-health-belief-scale-among-the-general-arabic-population
#11
Mohanad Naji Sahib
Background: Any educational program should be implemented with a good understanding of the population's beliefs. Therefore, the aims of this study were to validate the Arabic version of the Osteoporosis Health Belief Scale (OHBS-A) and assess the osteoprotective attitude among the Iraqi population. Methods: A cross-sectional design, with a random cluster sampling method from the community, was used. The forward-backward-forward translation method was used to translate the questionnaire from English to Arabic...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29439698/a-retrospective-analysis-of-bone-mineral-status-in-patients-requiring-spinal-surgery
#12
Tobias Schmidt, Katharina Ebert, Tim Rolvien, Nicola Oehler, Jens Lohmann, Luca Papavero, Ralph Kothe, Michael Amling, Florian Barvencik, Haider Mussawy
BACKGROUND: Impaired bone quality is associated with poor outcome of spinal surgery. The aim of the study was to assess the bone mineral status of patients scheduled to undergo spinal surgery and to report frequencies of bone mineral disorders. METHODS: We retrospectively analyzed the bone mineral status of 144 patients requiring spinal surgery including bone mineral density by dual-energy X-ray absorptiometry (DXA) as well as laboratory data with serum levels of 25-hydroxyvitamin D (25-OH-D), parathyroid hormone, calcium, bone specific alkaline phosphate, osteocalcin, and gastrin...
February 13, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29438745/an-automated-epifluorescence-microscopy-imaging-assay-for-the-identification-of-phospho-akt-level-modulators-in-breast-cancer-cells
#13
Elke Kaemmerer, Dane Turner, Amelia A Peters, Sarah J Roberts-Thomson, Gregory R Monteith
AKT is an enzyme of the PI3K/pAKT pathway, regulating proliferation and cell survival. High basal levels of active, phosphorylated AKT (pAKT) are associated with tumor progression and therapeutic resistance in some breast cancer subtypes, including HER2 positive breast cancers. Various stimuli can increase pAKT levels and elevated basal pAKT levels are a feature of PTEN-deficient breast cancer cell lines. The aim of this study was to develop an assay able to identify modulators of pAKT levels using an automated epifluorescence microscope and high content analysis...
February 10, 2018: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/29436385/cholesterol-efflux-capacity-does-not-associate-with-coronary-calcium-plaque-vulnerability-and-telomere-length-in-healthy-octogenarians
#14
Francesca Zimetti, Wladimir M Freitas, Alessandra M Campos, Mauricio Daher, Maria Pia Adorni, Franco Bernini, Andrei C Sposito, Ilaria Zanotti
Several studies revealed that traditional risk factors are less effective in predicting CVD risk in the elderly, suggesting the need to identify new biomarkers. Here we evaluated the association between serum cholesterol efflux capacity (CEC), an atheroprotective property of HDL recently identified as a novel marker of CVD risk, and atherosclerotic burden in a cohort of very old, healthy individuals. Serum CEC values were not significantly correlated neither with calcium score nor with markers of vulnerable plaque, such as positive remodeling, hypodensity, spotty calcification or napking-ring sign...
February 7, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29435665/coronary-artery-calcium-scoring-in-young-adults-evidence-and-challenges
#15
REVIEW
Marwan Saad, Naga Venkata Pothineni, Joseph Thomas, Richa Parikh, Swathi Kovelamudi, Dina Elsayed, Ramez Nairooz, Frederick Feit
PURPOSE OF REVIEW: This review aims to summarize the evidence and challenges of coronary artery calcium (CAC) scoring as a screening tool for coronary artery disease (CAD) in young adults. RECENT FINDINGS: Several cohort studies have highlighted the value of CAC scoring in CAD risk assessment in young adults. The largest study to date is the Coronary Artery Risk Development in Young Adults (CARDIA) study. The study examined patients at 18-30 years of age and demonstrated that the presence of any degree of CAC was associated with a higher risk of coronary events compared to zero CAC, with an incremental increase in the risk of events with higher scores...
February 12, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29434062/glucose-tolerance-insulin-secretion-sensitivity-characteristics-in-indian-children-with-cystic-fibrosis-a-pilot-study
#16
Vandana Jain, Santosh Kumar, Naval K Vikram, Mani Kalaivani, Surya Prakash Bhatt, Rajni Sharma, Kumar Kabra Sushil
Background & objectives: Cystic fibrosis (CF) is a life-limiting genetic condition resulting in chronic respiratory infections, pancreatic enzyme insufficiency and associated complications. This pilot study was undertaken to assess the glucose tolerance and insulin secretion and sensitivity among Indian children with CF. Methods: Children with CF under regular follow up at the Paediatric Pulmonology Clinic of a tertiary care hospital in New Delhi, India, were enrolled...
October 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29432592/ultra-low-dose-coronary-artery-calcium-scoring-using-novel-scoring-thresholds-for-low-tube-voltage-protocols-a-pilot-study
#17
Christoph Gräni, Jan Vontobel, Dominik C Benz, Sara Bacanovic, Andreas A Giannopoulos, Michael Messerli, Marvin Grossmann, Cathérine Gebhard, Aju P Pazhenkottil, Oliver Gaemperli, Philipp A Kaufmann, Ronny R Buechel
Aims: To determine if tube-adapted thresholds for coronary artery calcium (CAC) scoring by computed tomography at 80 kilovolt-peak (kVp) tube voltage and 70-kVp yield comparable results to the standard 120-kVp protocol. Methods and results: We prospectively included 103 patients who underwent standard scanning with 120-kVp tube voltage and additional scans with 80 kVp and 70 kVp. Mean body mass index (BMI) was 27.9 ± 5.1 kg/m2. For the lowered tube voltages, we applied novel kVp-adapted thresholds for calculation of CAC scores and compared them with standard 120-kVp scans using intraclass correlation and Bland-Altman (BA) analysis...
February 8, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29430885/abdominal-aortic-aneurysm-calcification-trying-to-identify-a-reliable-semiquantitative-method
#18
Marina Dias-Neto, Emmanuel Neves, Fábio Sousa-Nunes, Tiago Henriques-Coelho, Sérgio Sampaio
BACKGROUND: The main objective of this study was to assess the correlation between three semiquantitative and one computerized method based on Agatston Score (AS), when measuring abdominal aortic calcification (AAC) in abdominal aortic aneurysm (AAA) patients. Secondary aim was to access differences in AAC upon clinical variables, when different methods of calcium scoring are used. METHODS: This was an observational, retrospective, cross-sectional study. A database of AAA patients consecutively submitted to elective repair between 2008 and 2015 was used...
February 8, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29425964/alterations-of-l-type-voltage-dependent-calcium-channel-alpha-1-subunit-in-the-hippocampal-ca3-region-during-and-after-pilocarpine-induced-epilepsy
#19
Jie Hua Xu, Hui Wang, Wen Zhang, Feng Ru Tang
Voltage-dependent calcium channels (VDCC) have been shown to regulate neuronal excitability and their antagonists have been used clinically for the control of seizures. While functional studies of VDCC in epileptogenesis in the CA1 area of hippocampus or the dentate gyrus have been done, few studies were carried out in the CA3 area. Given the bursting characteristics of the CA3 neurons, we speculated that VDCC in the CA3 area might play an important role in the epileptogenesis. In the present study in the mouse pilocarpine model of temporal lobe epilepsy, we investigated the alterations of alpha 1 subunits of L-type VDCC in the CA3 area of the hippocampus at different stages of epileptogenesis, i...
February 7, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29424796/activation-of-sigma-1-receptor-by-cutamesine-attenuates-neuronal-apoptosis-by-inhibiting-endoplasmic-reticulum-stress-and-mitochondrial-dysfunction-in-a-rat-model-of-asphyxia-cardiac-arrest
#20
Jiahong Qin, Peng Wang, Yi Li, Lan Yao, Yuanshan Liu, Tao Yu, Jiali Lin, Xiangshao Fang, Zitong Huang
BACKGROUND: Global cerebral ischemic/reperfusion (I/R) injury after cardiac arrest (CA) is a major cause of mortality and morbidity in survivors of resuscitation. We utilized a rat model of asphyxia CA to explore the functional effects and mechanisms of Sigma-1 receptor (Sig-1R) activation in cerebral protection using the Sig-1R agonist cutamesine (SA-4503). METHODS: After resuscitation, the surviving rats were randomly divided into three groups (n = 18 each): (1) the CPR group (0...
February 8, 2018: Shock
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