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Two stage hepatectomy

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https://www.readbyqxmd.com/read/29672888/a-novel-fibroblast-growth-factor-15-dependent-and-bile-acid-independent-promotion-of-liver-regeneration-in-mice
#1
Bo Kong, Runbin Sun, Mingxing Huang, Monica D Chow, Xiao-Bo Zhong, Wen Xie, Yi-Horng Lee, Grace L Guo
The role of intestine-derived factors in promoting liver regeneration after partial hepatectomy (PHx) are not entirely known, but bile acids (BAs) and fibroblast growth factor 15 (Fgf15) that is highly expressed in the mouse ileum could promote hepatocyte proliferation. Fgf15 strongly suppresses the synthesis of BAs and emerging evidence indicates that Fgf15 is important for liver regeneration. The mechanisms by which Fgf15 promotes liver regeneration are unclear, but Fgf15 may do so indirectly by reducing BA levels and/or directly by promoting cell proliferation...
April 19, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29650855/-a-case-of-double-cancer-of-intrahepatic-cholangiocarcinoma-and-gastric-carcinoma-with-difficult-diagnosis-of-the-primary-tumor-with-peritoneal-metastasis
#2
Hiroyuki Kanomata, Yasuji Seyama, Hiroki Kudo, Toru Tanizawa, Masahiro Warabi, Masamichi Takahashi, Yujiro Matsuoka, Ikuo Wada, Masayuki Takegami, Yukio Miyamoto, Nobutaka Umekita
Double cancer of intrahepatic cholangiocarcinoma and gastric cancer is rare. A 62-year-old man underwent gastrectomy for gastric cancer. The pathological findings were tub1>tub2, m, ly0, v0, n0, Stage I A. Two years and a month later, a liver tumor(diameter of 3 cm)and a pelvic mass(diameter of 2.5 cm)were observed. Metastasis from gastric cancer was suspected and chemotherapy(SOX)was administered. However, after 5 courses, CT revealed worseningof the liver tumor (diameter of 12 cm)and pelvic mass(diameter of 3 cm)...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650846/-two-stage-radical-resection-of-a-case-of-colon-cancer-with-abdominal-wall-invasion-and-cholangiocarcinoma
#3
Takashi Sugimoto, Hidenori Kiyochi, Yohei Hosoda, Izumi Komoto, Yu Sasaki, Kazuhiro Nishiyama, Hokahiro Katayama, Nobuko Ogura, Shoji Tsunekawa, Yoshiro Taki, Mizuho Akahane, Teruyoshi Aoyama, Hiroko Matsumoto, Shoji Takami, Jun Kawai
A woman in her 50s was admitted to our hospital with fever and lower abdominal swelling. Abdominal CT/MRI examinations revealed irregular thickening of the transverse colon wall, which was attached to a subcutaneous abscess. An abdominal wall mass, a patent urachus, and a tumor in the 5th segment of the liver were also noted. Colonoscopy revealed type 2 advanced transverse colon cancer. The solitary, sessile tumor was observed at the apex of the bladder under cystoscopy, suggesting the formation of the urachal carcinoma...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29629319/liver-transplantation-for-unresectable-pancreatic-neuroendocrine-tumors-with-liver-metastases-in-an-era-of-transplant-oncology
#4
REVIEW
Keita Shimata, Yasuhiko Sugawara, Taizo Hibi
Patients with pancreatic neuroendocrine tumors (pNETs) very often present with a metastatic disease at the first diagnosis. Liver transplantation (LT) for unresectable pNET with liver metastases (pNETLM) has been described to prolong survival in highly selected patients, although outcomes were worse than those of patients who underwent LT for gastrointestinal NETLM (GI-NETLM). In this review, several proposed criteria are described with their rationale and controversies. Most of the data used to establish these criteria do not reflect the recent improvements of non-surgical treatments that has changed the landscape of treatment for pNETs, including the development of peptide receptor radionuclide therapy and molecular-targeted agents (sunitinib and everolimus)...
February 2018: Gland Surgery
https://www.readbyqxmd.com/read/29621745/associating-liver-partition-and-portal-vein-ligation-for-staged-hepatectomy-in-the-treatment-of-colorectal-liver-metastases-current-scenario
#5
Hauke Lang, Janine Baumgart, Jens Mittler
Associating Liver Partition and Portal vein ligation for Staged hepatectomy (ALPPS) has expanded the surgical armamentarium for patients with advanced and bilateral colorectal liver metastases. However, the enthusiasm that the medical fraternity had about ALPPS was hampered by a high mortality rate and early and frequent tumor recurrence. While surgical safety has improved, mainly due to technical refinements and a better patient selection, the oncological value in the face of early tumor recurrence remains unclear...
April 5, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29615295/radiologic-and-pathologic-response-to-neoadjuvant-chemotherapy-predicts-survival-in-patients-undergoing-the-liver-first-approach-for-synchronous-colorectal-liver-metastases
#6
Giammauro Berardi, Marc De Man, Stéphanie Laurent, Peter Smeets, Federico Tomassini, Riccardo Ariotti, Anne Hoorens, Jo van Dorpe, Oswald Varin, Karen Geboes, Roberto I Troisi
PURPOSE: To investigate the short- and long-term outcomes of liver first approach (LFA) in patients with synchronous colorectal liver metastases (CRLM), evaluating the predictive factors of survival. METHODS: Sixty-two out of 301 patients presenting with synchronous CRLM underwent LFA between 2007 and 2016. All patients underwent neoadjuvant chemotherapy. After neoadjuvant treatment patients were re-evaluated according to the Response Evaluation Criteria in Solid Tumors (RECIST)...
March 21, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29562418/-current-status-of-alpps-in-the-treatment-of-advanced-liver-cancer-with-insufficient-future-liver-remnant
#7
Y L Cao, W Li
Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) which represented a new two-steps liver resection procedures has been considered a revolutionary innovation for liver surgery technique in recent 10 years, it was first discovered by Professor Lang in Germany in 2007.The first step of the classic surgical procedures for portal vein ligation and liver parenchyma, until the future liver remnant (FLR) increased to a sufficient remnant then resect the right three-leaf liver.With the development of ALPPS, the method of hepatic parenchyma separation and isolation materials have been modified, which improves the safety of operation...
April 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29562411/-the-role-of-anatomical-hepatectomy-in-the-treatment-of-intrahepatic-cholangiocarcinoma
#8
X S Wu, Y Chen, Y P Jin, M L Li, W W Wu, W Gong, Y B Liu, S Y Peng
Objective: To evaluate the role of anatomical hepatectomy in the treatment of intrahepatic cholangiocarcinoma. Methods: The cases of intrahepatic cholangiocarcinoma who received curative surgery in two hospitals from 2010 to 2015 were analyzed retrospectively. Among the 98 patients enrolled in this study, 55 were male and 43 were female. The median age was 61 years. According to receiving anatomical hepatectomy or not, the 98 cases were divided into two groups: non-anatomical hepatectomy( n =30) and anatomical hepatectomy( n =68)...
April 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29538038/recurrence-rate-and-overall-survival-of-operated-ruptured-hepatocellular-carcinomas
#9
Gaëtan-Romain Joliat, Ismail Labgaa, Emilie Uldry, Nicolas Demartines, Nermin Halkic
OBJECTIVE: Hepatocellular carcinomas (HCC) can infrequently rupture and cause hemorrhage. Little is known on recurrence rate (RR) and overall survival (OS) in case of ruptured HCC. This study aimed to assess RR, time to recurrence, and OS of operated ruptured HCC. PATIENTS AND METHODS: All operated patients with HCC (1999-2015) were reviewed. Patient demographics, perioperative details, and postoperative outcomes of ruptured HCC were recorded. RR, time to recurrence, and OS were calculated...
March 13, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29533004/comparison-and-validation-of-the-prognostic-value-of-preoperative-systemic-immune-cells-in-hepatocellular-carcinoma-after-curative-hepatectomy
#10
Rui Liao, Cong Peng, Ming Li, De-Wei Li, Ning Jiang, Pei-Zhi Li, Xiong Ding, Qiao Wu, Cheng-You Du, Jian-Ping Gong
In this study, we aimed to compare and validate the prognostic abilities of preoperative systemic immune cells in hepatocellular carcinoma (HCC) after curative hepatectomy. We developed two nomograms to predict the postoperative recurrence-free survival (RFS) and overall survival (OS) after comparisons of the systemic immune cell prognostic scores. The two nomograms were constructed based on 305 patients who underwent curative hepatectomy for HCC. The predictive accuracy and discriminative ability of the nomograms were compared with six commonly used staging systems for HCC...
March 13, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29525540/large-hepatocellular-carcinoma-does-fibrosis-really-impact-prognosis-after-resection
#11
N Golse, A El Bouyousfi, F Marques, B Bancel, K Mohkam, C Ducerf, P Merle, M Sebagh, D Castaing, A Sa Cunha, R Adam, D Cherqui, E Vibert, J-Y Mabrut
BACKGROUND: Hepatectomy remains the standard treatment for large hepatocellular carcinoma (LHCC) ≥5cm. Fibrosis may constitute a contraindication for resection because of high risk of post-hepatectomy liver failure, but its impact on patient outcome and cancer recurrence remains ill defined. Our aim was to compare predictors of survival in patients with and without cirrhosis following hepatectomy for LHCC. METHODS: The data on consecutive patients undergoing hepatectomy for LHCC in two tertiary centres between 2012 and 2016 were reviewed...
March 7, 2018: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/29454099/two-stage-hepatectomy-vs-one-stage-major-hepatectomy-with-contralateral-resection-or-ablation-for-advanced-bilobar-colorectal-liver-metastases
#12
Takashi Mizuno, Jordan M Cloyd, Kiyohiko Omichi, Yun Shin Chun, Claudius Conrad, Ching-Wei D Tzeng, Steven H Wei, Thomas A Aloia, Jean-Nicolas Vauthey
BACKGROUND: Both two-stage hepatectomy (TSH) and one-stage hepatectomy (OSH) represent feasible strategies for resection of advanced bilobar colorectal liver metastases (CLM). However, the influence of the surgical approach on postoperative outcomes and overall survival (OS) is unknown. To define the optimal surgical approach for advanced bilobar CLM requiring right hemihepatectomy, we compared short-term and long-term outcomes following TSH and OSH with contralateral resection or radiofrequency ablation (RFA)...
February 14, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29453737/two-stage-hepatectomy-aiming-for-the-development-of-intrahepatic-venous-collaterals-for-multiple-colorectal-liver-metastases
#13
Harufumi Maki, Shouichi Satou, Kentaro Nakajima, Atsuki Nagao, Kazuteru Watanabe, Hitoshi Satodate, Satoshi Nara, Kaoru Furushima, Yasushi Harihara
BACKGROUND: Aggressive hepatectomy with venous resection has a higher risk of postoperative liver failure (POLF) than hepatectomy without venous reconstruction; however, venous reconstruction is technically demanding. We performed a novel two-stage hepatectomy (TSH) without venous reconstruction in a patient with bilobar multiple colorectal liver metastases located near the caval confluence, waiting for the development of intrahepatic venous collaterals between procedures. CASE PRESENTATION: A 60-year-old man was referred to our hospital with sigmoid colon cancer accompanied by intraabdominal abscess and two synchronous liver metastases...
February 16, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29444146/prediction-of-small-for-size-syndrome-after-extended-hepatectomy-tissue-characterization-by-relaxometry-diffusion-weighted-magnetic-resonance-imaging-and-magnetization-transfer
#14
Christian Eberhardt, Moritz C Wurnig, Andrea Wirsching, Cristina Rossi, Idana Feldmane, Mickael Lesurtel, Andreas Boss
This study aimed to monitor the course of liver regeneration by multiparametric magnetic-resonance imaging (MRI) after partial liver resection characterizing Small-for-Size Syndrome (SFSS), which frequently leads to fatal post-hepatectomy liver failure (PLF). Twenty-two C57BL/6 mice underwent either conventional 70% partial hepatectomy (cPH), extended 86% partial hepatectomy (ePH) or SHAM operation. Subsequent MRI scans on days 0, 1, 2, 3, 5 and 7 in a 4.7T MR Scanner quantified longitudinal and transverse relaxation times, apparent diffusion coefficient (ADC) and the magnetization-transfer ratio (MTR) of the regenerating liver parenchyma...
2018: PloS One
https://www.readbyqxmd.com/read/29439275/is-enhanced-one-stage-hepatectomy-a-safe-and-feasible-alternative-to-the-two-stage-hepatectomy-in-the-setting-of-multiple-bilobar-colorectal-liver-metastases-a-comparative-analysis-between-two-pioneering-centers
#15
Guido Torzilli, Luca Viganò, Matteo Cimino, Katsunori Imai, Eric Vibert, Matteo Donadon, Doaa Mansour, Denis Castaing, Ren Adam
BACKGROUND: Two-stage hepatectomy (TSH) is the present standard for multiple bilobar colorectal metastases (CLM). As alternative, ultrasound-guided one-stage hepatectomy (E-OSH) has been proposed even for deep-located nodules to compare TSH and E-OSH. METHODS: All consecutive TSH at the Paul Brousse Hospital and E-OSH at the Humanitas Research Hospital were considered. The inclusion criteria were ≥6 CLM, ≥3 CLM in the left liver, and ≥1 lesion with vascular contact...
February 13, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29425829/assessment-and-optimization-of-liver-volume-before-major-hepatic-resection-current-guidelines-and-a-narrative-review
#16
REVIEW
Adeel S Khan, Sandra Garcia-Aroz, Mohammad A Ansari, Syed M Atiq, Michael Senter-Zapata, Kathryn Fowler, M B Doyle, W C Chapman
Post hepatectomy liver failure (PHLF) remains a significant cause of morbidity and mortality after major liver resection. Although the etiology of PHLF is multifactorial, an inadequate functional liver remnant (FLR) is felt to be the most important modifiable predictor of PHLF. Pre-operative evaluation of FLR function and volume is of paramount importance before proceeding with any major liver resection. Patients with inadequate or borderline FLR volume must be considered for volume optimization strategies such as portal vein embolization (PVE), two stage hepatectomy with portal vein ligation (PVL), Yttrium-90 radioembolization, and associating liver partition and portal vein ligation for staged hepatectomy (ALPPS)...
February 6, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29394831/-a-case-of-a-two-stage-hepatectomy-for-irresectable-colorectal-cancer-liver-metastases
#17
Yoshiro Yukawa, Kohei Murata, Yoshinori Kagawa, Takuya Sakamoto, Junichi Inatome, Atsushi Naito, Kohei Murakami, Yoshiteru Katsura, Yoshiaki Ohmura, Atsushi Takeno, Chiyomi Egawa, Shinichi Nakatsuka, Takeshi Kato, Shigeyuki Tamura, Yutaka Takeda
A 60-year-oldman was diagnosedwith ascending colon cancer with multiple bilobar metastases. He then received7 courses of tegafur-gimeracil-oteracil andoxaliplatin (SOX)plus panitumumab as downstaging chemotherapy. This treatment significantly reducedthe size of the metastatic tumor, andwe subsequently triedto perform a curative resection. A twostage hepatectomy was plannedto avoidthe risk of hepatic failure from small future liver remnant. First, the anterior segmentectomy andthe left portal vein ligation were performed...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29362330/-two-cases-of-colon-metastasis-of-gastric-cancer-by-different-metastasis-pathway
#18
Ichiro Higuchi, Yosuke Akiyama, Akira Ishikawa, Sanae Hosomi, Takahiko Tanigawa, Yasunori Hasuike, Makoto Miyamoto
We treated 2 cases ofcolon metastasis ofgastric cancer considered to be caused by different pathway. Case 1 was a 55- year-old male with gastric cancer associated with metastases for lymph node, gallbladder, and liver. Curative surgical treatment of distal gastrectomy, partial hepatectomy, cholecystectomy and lymph node dissection was performed. The final find- ing was, L, Less, Type 3, pT4b(GB), tub2, pN3a(10/20), sP0, CY0, pH1, pM1, Stage IV , R0. Ten months after, ileocecal resection was performed, as a tumor was detected in the cecum...
January 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29359240/feasibility-of-percutaneous-intrahepatic-split-by-microwave-ablation-pisa-after-portal-vein-embolization-for-hypertrophy-of-future-liver-remnant-the-radiological-stage-1-alpps
#19
Alessandro Lunardi, Rosa Cervelli, Duccio Volterrani, Saverio Vitali, Carlo Lombardo, Giulia Lorenzoni, Laura Crocetti, Irene Bargellini, Daniela Campani, Luca Emanuele Pollina, Roberto Cioni, Davide Caramella, Ugo Boggi
PURPOSE: To assess the feasibility of radiological stage-1 ALPPS, associating liver partition and portal vein ligation for staged hepatectomy, by combining portal vein embolization (PVE) with percutaneous intrahepatic split by ablation (PISA). MATERIALS AND METHODS: Three patients (mean age 65.0 ± 7.3 years) underwent PVE and PISA. PISA was performed 21 days after PVE by microwave ablation to create a continuous intrahepatic cutting plane. Abdominal CT examinations were performed before and after PVE and PISA...
May 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29325786/a-proactive-outreach-intervention-that-decreases-readmission-after-hepatectomy
#20
Nisha Narula, Bradford J Kim, Catherine H Davis, Whitney L Dewhurst, Leigh A Samp, Thomas A Aloia
BACKGROUND: After hepatectomy, 7%-19% of patients are readmitted within 30 days, accounting for substantial cost and poor patient experience. The purpose of this study was to analyze the impact of a proactive outreach intervention on readmissions. METHODS: Consecutive patients undergoing hepatectomy by a single surgeon 2012-2016 were identified in a prospectively maintained database. In August 2013 a postoperative intervention was implemented; an advanced practice provider called each patient within 72 hours of discharge...
April 2018: Surgery
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