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https://www.readbyqxmd.com/read/29908323/novel-myxobolus-and-ellipsomyxa-species-cnidaria-myxozoa-parasiting-brachyplatystoma-rousseauxii-siluriformes-pimelodidae-in-the-amazon-basin-brazil
#1
Suellen A Zatti, Stephen D Atkinson, Antônio A M Maia, Lincoln L Corrêa, Jerri L Bartholomew, Edson A Adriano
We describe two novel myxosporean parasites from Brachyplatystoma rousseauxii, an economically important freshwater catfish from the Amazon basin, Brazil. Myxobolus tapajosi n. sp., was found in the gill filaments of 23.5% of 17 fish, with myxospores round to oval in frontal view and biconvex in lateral view: length 15 (13.5-17) μm and width 10.7 (9.6-11.4) μm; polar capsules equal, length 5.8 (4.6-7.1) μm and width 3 (2.3-3.8) μm containing polar tubules with 6-7 turns. Ellipsomyxa amazonensis n. sp. myxospores were found floating freely or inside plasmodia in the gall bladder of 23...
June 13, 2018: Parasitology International
https://www.readbyqxmd.com/read/29893894/new-developments-in-systemic-therapy-for-advanced-biliary-tract-cancer
#2
Chigusa Morizane, Makoto Ueno, Masafumi Ikeda, Takuji Okusaka, Hiroshi Ishii, Junji Furuse
Biliary tract cancer, carcinoma of the extrahepatic bile ducts, carcinoma of the gall bladder, ampullary carcinoma and intrahepatic cholangiocarcinoma are often identified at an advanced stage and have poor prognoses. Although effective chemotherapy regimens are needed, their development remains unsatisfactory. From the results of a phase III clinical trial (ABC-02 trial), gemcitabine plus cisplatin is the standard first-line chemotherapeutic regimen for advanced biliary tract cancer. A phase III trial of gemcitabine plus cisplatin vs...
June 11, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29884666/gallbladder-volvulus-with-segmental-right-liver-lobe-hypoplasia-atrophy-a-preoperative-diagnostic-dilemma
#3
Shameel Musthafa, Zia Aftab, Syed Muhammad Ali, Maneesh Khanna
Gallbladder volvulus (GBV) due to rotation of the gall bladder (GB) around its own mesentery is a rare surgical emergency and often identified intraoperatively. Typically, cholecystitis is the initial clinical diagnosis, but a high index of suspicion on imaging can alert the physician for the possibility of GBV requiring urgent surgical intervention. We describe a case of a young female patient with hypoplasia/atrophy of the posterior segment of the right liver lobe and a GB with no hepatic attachments but only mesenteric pedicle...
June 8, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29877992/123i-iomazenil-whole-body-imaging-to-detect-hepatic-carboxylesterase-drug-metabolizing-enzyme-activity
#4
Asuka Mizutani, Masato Kobayashi, Ken-Ichi Fujita, Kotaro Takahashi, Tsuzumi Hokama, Hiroaki Takasu, Kodai Nishi, Ryuichi Nishii, Naoto Shikano, Kazuki Fukuchi, Keiichi Kawai
OBJECTIVES: Drugs are mainly metabolized by hepatic enzymes, the activity of which can differ between individuals. Although it is ideal to measure the hepatic clearance of liver-targeted drugs in individualized medicine, blood enzyme tests typically measure metabolic drug clearance in the entire body, and not just in the liver. We investigated whether I-iomazenil imaging can directly assess and quantify the activity of hepatic drug-metabolizing enzymes. MATERIALS AND METHODS: Hepatic enzymes that metabolize I-iomazenil were identified by thin-layer chromatography in mouse liver homogenates with bis(4-nitrophenyl) phosphate (BNPP) inhibitor for carboxylesterase enzymes and nicotinamide adenine dinucleotide phosphate (NADPH) generator for cytochrome P450 enzymes...
June 5, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29850458/efficacy-and-safety-of-lumen-apposing-self-expandable-metal-stents-for-eus-guided-cholecystostomy-a-meta-analysis-and-systematic-review
#5
REVIEW
Nikhil R Kalva, Vishwas Vanar, David Forcione, Matthew L Bechtold, Srinivas Reddy Puli
Background: Patients with acute cholecystitis are treated with early cholecystectomy. A subset of patients are unfit for surgery due to comorbidities and late presentation. Prompt gall bladder drainage (GBD) with percutaneous or endoscopic approach remains a viable therapeutic option for nonoperative candidates. Endoscopic ultrasound (EUS) guided transluminal gall bladder drainage (EUS-GBD) continues to evolve as an alternative approach to percutaneous drainage. With continued refinement in stent technology, lumen apposing self-expandable metal stent (LAMS) offers several advantages...
2018: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29848433/utility-of-routine-gall-bladder-histopathology-after-living-donor-hepatectomy-in-liver-transplantation
#6
Abu Bakar Hafeez Bhatti, Ihsan Ul Haq, Imran Nazir Ahmed, Raenah Bilal, Faisal Saud Dar
Intraoperative cholangiogram with cholecystectomy is a routinely performed procedure in living donor liver transplantation (LDLT).The objective of this study was to determine the frequency of gall bladder pathology in healthy living donors and whether routine histopathology can be omitted. This was a retrospective review of 366 donors who underwent donor hepatectomy between 2012 and 2016. Primary outcome of interest was frequency of abnormal histopathology findings in removed gall bladder specimen; and if their distribution was different with respect to gender, age and BMI...
June 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29809126/-metastasis-from-a-malignant-melanoma-presenting-as-a-gall-bladder-polyp
#7
Helene Juul Würtz, Sönke Detlefsen, Alan Patrick Ainsworth
Gall bladder polyps larger than 10 mm hold an increased risk of malignancy. In this case report, a metastasis from a superficial spreading malignant melanoma level IV presented as a large gall bladder polyp in a 52-year-old woman. The melanoma had been surgically resected eight years earlier. The most frequent distant metastatic sites of malignant melanoma are soft tissue, lung, liver, skin and brain, but metastasis to the gallbladder is rare. It is important to refer patients with large gall bladder polyps to centres with expertise in liver surgery...
June 4, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29803752/a-novel-ultrasonographic-scoring-system-of-sinusoidal-obstruction-syndrome-after-hematopoietic-stem-cell-transplantation
#8
Mutsumi Nishida, Kaoru Kahata, Eiko Hayase, Akio Shigematsu, Megumi Sato, Yusuke Kudo, Satomi Omotehara, Takahito Iwai, Junichi Sugita, Hitoshi Shibuya, Chikara Shimizu, Takanori Teshima
BACKGROUND: Sinusoidal obstruction syndrome (SOS)/hepatic veno-occlusive disease (VOD) is a well-documented complication after hematopoietic stem cell transplantation (HSCT). Transabdominal ultrasonography (US) enables to visualize blood flow abnormalities and is therefore useful for the diagnosis of SOS/VOD. We herein prospectively evaluated accuracy of a novel ultrasonographic diagnostic scoring system of SOS/VOD based on US findings. METHODS: We carried out US in 106 patients on day 14 and when SOS/VOD was suspected after allogeneic HSCT...
May 24, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29796007/b-chronic-lymphocytic-leukemia-showed-triple-transformation-to-diffuse-large-b-cell-cd20-negative-and-t-cell-neoplasm-during-ofatumumab-treatment-a-case-report
#9
Osamu Imataki, Makiko Uemura
Background: Chronic lymphocytic leukemia (CLL) is a mature lymphoid neoplasm currently categorized as an indolent type of malignant lymphoma. CLL progresses slowly over years, but it eventually transforms to a more aggressive lymphoma such as the diffuse large B-cell (DLBCL) type, also known as Richter's syndrome. Case presentation: We treated a 69-year-old Japanese male who was histologically diagnosed with Richter's syndrome after 6 years of CLL. His lymphadenopathy had systemically progressed for years, with lymphocyte counts of less than 10,000 cells/μL and a disease status of Rai classification stage I and Binet classification B...
2018: BMC Clinical Pathology
https://www.readbyqxmd.com/read/29791985/-management-of-acute-cholecystitis
#10
REVIEW
Seung Ok Lee, Sung Kyun Yim
Acute cholecystitis is a common serious complication of gallstones. The reported mortality of acute cholecystitis is approximately 3%, but the rate increases with age or comorbidity of the patient. If appropriate treatment is delayed, complications can develop as a consequence with a grave prognosis. The current standard of care in acute cholecystitis is an early laparoscopic cholecystectomy with the appropriate administration of fluid, electrolyte, and antibiotics. On the other hand, the severity of the disease and patient's operational risk must be considered...
May 25, 2018: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29790924/typhoidal-salmonella-serovars-ecological-opportunity-and-the-evolution-of-a-new-pathovar
#11
Hirotaka Hiyoshi, Connor R Tiffany, Denise N Bronner, Andreas J Bäumler
Typhoid and paratyphoid fever are severe systemic infections caused by human-adapted typhoidal Salmonella serovars that are indistinguishable in their clinical presentation, but differ from human gastroenteritis caused by zoonotic non-typhoidal Salmonella serovars. Typhoidal Salmonella serovars evolved from ancestral gastrointestinal pathogens through genetic changes that supported a change in pathogen ecology. Typhoidal Salmonella serovars share virulence properties that were acquired through convergent evolution and therefore this group is not defined by the presence of shared virulence genes that are absent from non-typhoidal Salmonella serovars...
May 21, 2018: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/29783219/-clinical-and-laboratory-features-of-cholelithiasis-in-patients-with-type-2-diabetes-by-gender
#12
Natalya I Dyakiv-Koreiba
OBJECTIVE: Introduction: Today, diabetes is considered a factor that provokes the development of bile duct disease. Cholelithiasis is associated with such risk factors as aging, high body mass index, female sex, genetic predisposition, alcohol abuse, high concentration of triglycerides and cholesterol, low density lipoprotein in blood plasma The aim of the work is to analyze the clinical and laboratory features of the pathology of the gall bladder in patients with type 2 diabetes, depending on the sex...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29750128/clinicohistopathological-characteristics-of-malignant-melanoma-in-the-gall-bladder-a-case-report-and-review-of-the-literature
#13
Schmidt Adrian, Caspar Clemens, Schmidt-Weiss Elisabeth, Stadlmann Sylvia
Objective: Primary gall bladder melanoma is a rare and controversial entity. So far, only 36 cases are documented in the literature. Metastatic melanoma targeting the gall bladder, however, has been reported to occur in about 15-20% of melanoma patients and is much more common. Methods: Based on the case of a 58-year-old woman presenting with multiple melanoma nodules in the gall bladder, we searched in the available literature in PubMed for articles describing a "primary melanoma of the gallbladder" regardless of language used...
2018: Case Reports in Pathology
https://www.readbyqxmd.com/read/29737313/laparoscopic-management-of-a-case-of-accessory-gall-bladder-with-review-of-literature
#14
Guru Prasad Painuly, Ankur Gupta, Mini Singhal, Bhavna Bansal
Gall bladder duplication is a rare congenital anomaly. True duplication is still rarer. Pre-operative detection helps in avoiding complications or missing the gall bladder during surgery. Ultrasonography (USG) and magnetic resonance cholangiography are investigation of choice. Laparoscopic cholecystectomy is the preferred modality for management of double gall bladder. We present a case diagnosed as cholelithiasis on USG. While doing laparoscopic surgery 2 gall bladders were found. She had a normal gall bladder that was lying in the supraduodenal area...
May 4, 2018: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29727803/synchronous-double-primary-cancers-of-the-extrahepatic-bile-duct-a-case-report-and-literature-review
#15
Takeshi Nishi, Yoshitoshi Sato, Takuya Hanaoka, Takuya Takahashi, Hiroshi Miura, Kenji Takubo
BACKGROUND: Double cancers of the biliary tract system are rare. Most of these cancers are synchronous double cancers of the gall bladder and bile duct, associated with pancreaticobiliary maljunction (PBM). Synchronous double cancers of the extrahepatic bile duct without PBM are especially rare, and only 4 cases have been reported. CASE PRESENTATION: A 78-year-old woman was admitted to our hospital for examination of hyperbilirubinemia and liver dysfunction. Contrast-enhanced abdominal computed tomography, Magnetic resonance cholangiopancreatography and endoscopic retrograde cholangiopancreatography revealed 2 stenotic regions in the common bile duct: at its junction with the cystic duct and in the distal bile duct...
April 27, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29721656/effects-of-miconazole-clotrimazole-and-praziquantel-combinations-against-the-liver-fluke-opisthorchis-felineus-in-vivo-and-in-vitro
#16
Maria Y Pakharukova, Yuri V Pakharukov, Viatcheslav A Mordvinov
The liver fluke Opisthorchis felineus (Rivolta, 1884) is the causative agent of opisthorchiasis felinea in Eurasia. Opisthorchiasis is a serious human and fish-eating animal's disease affecting bile ducts and the gall bladder. Currently, the main drug for specific therapy of opisthorchiasis is praziquantel. We have previously shown that azole inhibitors of O. felineus cytochrome P450 significantly reduced survival of the worms in vitro. Here, we studied in vitro anthelmintic effects of drug combinations involving azole substances approved by the US Food and Drug Administration together with praziquantel against adult or juvenile O...
May 2, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29705976/feasibility-study-of-postoperative-adjuvant-chemotherapy-with-s-1-in-patients-with-biliary-tract-cancer
#17
Kohei Nakachi, Masaru Konishi, Masafumi Ikeda, Kazuaki Shimada, Takuji Okusaka, Akio Saiura, Hiroshi Ishii, Masanori Sugiyama, Junji Furuse, Hirohiko Sakamoto, Tomotaka Shimamura, Takehiro Ohta
BACKGROUND: The role of adjuvant chemotherapy has not yet been established for patients with resected biliary tract cancer. S-1 has been shown to exert activity against advanced biliary tract cancer. Therefore, we evaluated the feasibility of adjuvant chemotherapy with S-1 in patients with resected biliary tract cancer. METHODS: Patients with complete macroscopic resection of intrahepatic/extrahepatic bile duct, gall bladder, or ampullary cancer were eligible. S-1 was administered orally twice daily for 4 weeks every 6 weeks, up to 4 cycles...
April 28, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29669131/effect-of-dietary-fructooligosaccharide-supplementation-on-internal-organs-salmonella-colonization-immune-response-ileal-morphology-and-ileal-immunohistochemistry-in-laying-hens-challenged-with-salmonella-enteritidis
#18
Pratima Adhikari, Douglas E Cosby, Nelson A Cox, Monique S Franca, Susan M Williams, Robert M Gogal, Casey W Ritz, Woo K Kim
A study was conducted to evaluate the efficacy of fructooligosaccharides (FOS) in controlling the infection of Salmonella Enteritidis (SE) in White Leghorns. A total of 30 laying hens (white leghorns W-36) were challenged both orally and cloacally with approximately 108 colony-forming units of nalidxic acid resistant SE (SENAR) and divided into 3 treatments: 1) SENAR challenged + 0.0% FOS, 2) SENAR challenged + 0.5% FOS (Nutraflora), and 3) SENAR challenged + 1.0% FOS. SENAR recovery via fecal shedding was measured at 3- and 6-d post-infection (dpi), whereas in the ceca and internal organs, SENAR recovery was measured at 7-d post-infection...
April 13, 2018: Poultry Science
https://www.readbyqxmd.com/read/29650819/-a-case-report-of-neuroendocrine-carcinoma-in-the-gall-bladder-showing-recurrence-shortly-after-surgery
#19
Yoshihiro Uchino, Sonofu Taketani, Nobuhisa Hirayu, Koji Shiota, Hironobu Sou, Satoshi Taniwaki, Tetsuo Imamura
A55 -year-old woman with a 10×8mm protuberant gallbladder lesion visited our hospital. To determine possible malignancy, she underwent laparoscopic excision biopsy of the gallbladder, and pathological findings revealed an endocrine carcinoma in the gallbladder. Surgery involved extrahepatic bile duct resection, gallbladder bed resection, and hepatic portal lymph node resection. Recurrence in the peritoneal lymph node was observed in the early postoperative period. Chemotherapy was initiated with cisplatin and irinotecan, and continues 18 months post-operatively...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29649951/biliary-ascariasis-presenting-with-gangrenous-perforation-of-the-gall-bladder-report-of-a-case-and-brief-review-of-literature
#20
Ankush Sharma, Priyansh Jariwala, Navneet Kaur
The most common cause of gallbladder perforation is calculous cholecystitis. Rarer causes include trauma, iatrogenic injuries, biliary stasis and gall bladder ischemia. We report a case of gall bladder gangrene with perforation, secondary to extensive ascariasis. A 45-year-old woman presented with acute intestinal obstruction and jaundice. She had abdominal distension and right hypochondrial tenderness. Abdominal radiography showed dilated bowel loops and ultrasonogram showed worms in the small intestine and biliary tree...
January 1, 2018: Tropical Doctor
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