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https://www.readbyqxmd.com/read/29139146/effects-of-the-sodium-glucose-cotransporter-2-sglt2-inhibitor-velagliflozin-a-new-drug-with-therapeutic-potential-to-treat-diabetes-in-cats
#1
M Hoenig, M Clark, D J Schaeffer, D Reiche
Sodium-glucose cotransporter 2 (SGLT2) inhibitors are used in the treatment of human diabetics. They increase glucose excretion and correct hyperglycemia. We examined the investigational SGLT2 inhibitor velagliflozin in two groups of six neutered adult obese cats (equal gender distribution). Placebo (Pl) or drug (D; 1 mg/kg) was administered for 35 days. Routine blood examinations, fructosamine, beta-hydroxybutyrate (BHB), nonesterified fatty acids (NEFA), glucagon, adiponectin, and leptin were measured before and after treatment, also water intake, and urinary electrolytes, glucose, and volume...
November 15, 2017: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29134099/assessment-of-owner-directed-aggressive-behavioural-tendencies-of-dogs-in-situations-of-possession-and-manipulation
#2
Anna Bálint, Gabriella Rieger, Ádám Miklósi, Péter Pongrácz
Excessive aggression is a common behaviour problem in dogs that can have various destructive effects on the affected people and the implicated dog. Aggressive behaviour directed towards the owner or other family members is one of the most frequently occurring aggressive phenotypes. Here, we examine the reliability of a short questionnaire assessing aggressive behaviours by two, contextually different behavioural tests: 'take away bone' and 'roll over'. Based on dogs' behaviour in the tests, we sorted dogs (N = 93) in two groups for each test, namely a less and a more disobedient/resistant group...
October 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/29132371/survey-of-vector-borne-agents-in-feral-cats-and-first-report-of-babesia-gibsoni-in-cats-on-st-kitts-west-indies
#3
Patrick John Kelly, Liza Köster, Jing Li, Jilei Zhang, Ke Huang, Gillian Carmichael Branford, Silvia Marchi, Michel Vandenplas, Chengming Wang
BACKGROUND: As there is little data on vector-borne diseases of cats in the Caribbean region and even around the world, we tested feral cats from St Kitts by PCR to detect infections with Babesia, Ehrlichia and spotted fever group Rickettsia (SFGR) and surveyed them for antibodies to Rickettsia rickettsii and Ehrlichia canis. RESULTS: Whole blood was collected from apparently healthy feral cats during spay/ neuter campaigns on St Kitts in 2011 (N = 68) and 2014 (N = 52)...
November 13, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29130572/ischemic-optic-neuropathy-in-a-dog-with-acute-bilateral-blindness-and-primary-systemic-hypertension
#4
L Mari, R Stavinohova, E Dominguez, J Premont, J Oliver, L De Risio
A 6-year-old neutered female Jack Russell terrier was investigated for sudden onset prechiasmatic bilateral blindness, left circling, reduced proprioception in the right pelvic limb and right facial allodynia. Electroretinography was normal. Magnetic resonance imaging (MRI) examination revealed that the right optic nerve and the optic chiasm were hyperintense on diffusion weighted imaging and hypointense on apparent diffusion coefficient map consistent with ischemic optic neuropathy. A concurrent lacunar infarct was detected in the left rostral colliculus...
November 12, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29126424/salivary-ph-calcium-phosphorus-and-selected-enzymes-in-healthy-dogs-a-pilot-study
#5
Ilaria Iacopetti, Anna Perazzi, Tamara Badon, Silvia Bedin, Barbara Contiero, Rebecca Ricci
BACKGROUND: Saliva in dogs, as in humans, is a complex fluid secreted by different salivary glands in the oral cavity to protect the oral mucosa and teeth. The use of saliva as a substitute for blood in diagnosing and prognosticating disease in humans is widely accepted. Salivary biochemistry has also been used as a marker for periodontal disease in humans. No studies have as yet investigated the relation between salivary biochemistry and periodontal disease in dogs, however; neither has the salivary composition of healthy dogs with no oral disease been assessed...
November 10, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29123915/global-cerebral-ischemia-with-subsequent-respiratory-arrest-in-a-cat-after-repeated-use-of-a-spring-loaded-mouth-gag
#6
Emily A Hartman, Robert J McCarthy, Mary A Labato
Case summary: A 10-year-old neutered male domestic shorthair cat was evaluated because of signs of stertorous breathing and reverse sneezing of 8 months' duration. A CT scan performed 1 week before evaluation indicated nasopharyngeal stenosis or collapse. Increased respiratory effort, stertorous breathing, coughing, reverse sneezing, bilateral black ocular discharge and mucoid left nasal discharge were noted. Rhinoscopy suggested possible nasopharyngeal stenosis. Balloon dilation was attempted but unsuccessful...
July 2017: JFMS open reports
https://www.readbyqxmd.com/read/29115902/open-mouth-jaw-locking-in-cats-a-literature-review-and-use-of-computed-tomography-in-three-cases
#7
Anna E Nutt, Thomas Anderson, Margherita Gracis, Ivan Doran, Chris Warren-Smith, Sorrel J Langley-Hobbs
Case series summary This report summarises and reviews the published cases of open-mouth jaw locking in cats and describes three further cases. Case 1 was a 5-year-old, 5.3 kg male neutered domestic shorthair cat. CT identified changes consistent with temporomandibular joint (TMJ) dysplasia with osseous degenerative changes, and the cat subsequently underwent bilateral partial zygomectomy with bilateral partial coronoidectomy. Case 2 was a 10-year-old, 6.0 kg male neutered Exotic Shorthair. Aside from a fracture of the left maxillary canine tooth crown and absence of the left maxillary fourth premolar tooth, no abnormalities were found on CT scan...
November 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29099270/accuracy-of-a-point-of-care-luteinizing-hormone-test-for-help-in-distinguishing-between-sexually-intact-and-ovariectomized-or-castrated-domestic-cats
#8
Matthew R Krecic, Brian A DiGangi, Brenda Griffin
Objectives The aim of this study was to determine the accuracy of a commercial luteinizing hormone (LH) test as an aid in distinguishing between sexually intact and ovariectomized or castrated domestic cats. Methods Convenience serum samples collected from sexually intact female and male cats (n = 67) undergoing elective sterilization surgery and archived sera from ovariectomized and castrated cats (n = 54) were tested for LH using a commercial diagnostic assay. Test results were compared with the known reproductive status of the cats...
November 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29081582/quantitative-assessment-of-muscle-in-dogs-using-a-vertebral-epaxial-muscle-score
#9
Lisa M Freeman, James Sutherland-Smith, Lori R Prantil, Amy F Sato, John E Rush, Bruce A Barton
Muscle loss associated with disease (cachexia) or with aging (sarcopenia) is common in dogs, but clinically relevant methods for quantifying muscle loss are needed. We previously validated an ultrasound method of quantifying muscle size in dogs in a single breed. The goal of this study was to assess the variability and reproducibility of the Vertebral Epaxial Muscle Score (VEMS) in other dog breeds. Static ultrasound images were obtained from 38 healthy, neutered dogs of 5 different breeds between 1- and 5-years-old...
October 2017: Canadian Journal of Veterinary Research, Revue Canadienne de Recherche Vétérinaire
https://www.readbyqxmd.com/read/29080770/atypical-fatal-sarcocystosis-associated-with-sarcocystis-neurona-in-a-white-nosed-coati-nasua-narica-molaris
#10
Jitender P Dubey, John G Trupkiewicz, Shiv K Verma, Joseph D Mowery, Gloria Adedoyin, Tim Georoff, Michael E Grigg
The protozoan parasite Sarcocystis neurona is an important cause of disease in horses (equine protozoal myeloencephalitis, EPM) and marine mammals. Isolated reports of clinical EPM-like disease have been documented in a zebra, raccoon, domestic cat, domestic dog, ferret, skunk, mink, lynx, red panda and fisher. The predominant disease is encephalomyelitis associated with schizonts in neural tissues. Here, we report highly disseminated sarcocystosis, in many tissues of a captive White-nosed coati (Nasua narica molaris)...
November 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/29080763/delineation-of-an-endemic-tick-paralysis-zone-in-southeastern-australia
#11
Zoe Whitfield, Mark Kelman, Michael P Ward
Tick paralysis has a major impact on pet dog and cat populations in southeastern Australia. It results from envenomation by Ixodes holocyclus and Ixodes cornuatus ticks, the role of Ixodes cornuatus in the epidemiology of this disease in Australia being unclear. The aim of this study was to describe the geographical distribution of tick paralysis cases in southeastern Australia using data from a national disease surveillance system and to compare characteristics of "endemic" cases with those reported outside this endemic zone ("sporadic" cases)...
November 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/29056703/complete-resolution-of-a-recurrent-canine-anal-sac-squamous-cell-carcinoma-with-palliative-radiotherapy-and-carboplatin-chemotherapy
#12
Antonio Giuliano, Jane Dobson, Sarah Mason
Anal sac squamous cell carcinoma (SCC) is a rare tumor in dogs. Only eight cases have been described in the literature, and previous reports of treatment only describe surgery or palliative treatment with non-steroidal anti-inflammatory drugs. We report a case of a 12-year-old female neutered Labrador with locally advanced anal sac SCC. The dog was treated with four cycles of carboplatin 300 mg/m² and four weekly fractions of 8.5 Gy radiation. The dog achieved a complete response, and one year later the dog is still alive and well with no evidence of tumor recurrence...
September 14, 2017: Veterinary Sciences
https://www.readbyqxmd.com/read/29037850/comparison-of-dna-fragmentation-of-frozen-thawed-epididymal-sperm-of-dogs-using-sperm-chromatin-structure-analysis-and-sperm-chromatin-dispersion-test
#13
I Ortiz, M Urbano, J Dorado, J M Morrell, E Al-Essawe, A Johannisson, M Hidalgo
The aim of this study was to compare sperm DNA fragmentation of frozen-thawed epididymal sperm of dogs using the SCSA (Sperm Chromatin Structure Assay) and SCDt (Sperm Chromatin Dispersion test). For this purpose, epididymis from neutered dogs were minced and incubated in a Tris-based extender. The recovered sperm were frozen in a two-step cooling protocol with Tris-based, egg yolk extender and increasing glycerol concentrations, and stored in liquid nitrogen. After thawing, each replica was incubated at 38°C for 24h...
October 12, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/29035837/testicular-cytology-by-fine-needle-aspiration-in-domestic-cats
#14
D P Leme, E Visacre, V B Castro, M D Lopes
In cases where semen collection in tom-cats is not possible, FNA of testes is the alternative to evaluate sperm production. Although this technique for the diagnosis of fertility problems has been well discussed in other mammals (men, dogs, stallions), data for domestic cats are limited. Therefore, the aim of this study was to verify the reliability of FNA using needles of small diameters (22G and 29G) in testes of domestic cats of different ages to assess the spermatogenesis status and to present description of germ cells and Sertoli cells for cytological examinations...
October 9, 2017: Theriogenology
https://www.readbyqxmd.com/read/29033245/clinical-comparison-of-alfaxalone-ketamine-and-propofol-following-medetomidine-and-methadone-in-dogs
#15
Kate L White, David Yates
OBJECTIVE: To compare the clinical effects of alfaxalone, ketamine and propofol in dogs following premedication with medetomidine and methadone. STUDY DESIGN: Prospective, 'blinded' and randomized clinical study. ANIMALS: A total of 75 male dogs presented for neutering at a charity clinic. METHODS: Dogs were allocated to be administered alfaxalone, ketamine or propofol following premedication with medetomidine (20 μg kg(-1)) and methadone (0...
March 6, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29028571/identifying-ovarian-tissue-in-the-bitch-using-anti-m%C3%A3-llerian-hormone-amh-or-luteinizing-hormone-lh
#16
Helene Alm, Bodil S Holst
Reliable methods for determining whether or not a bitch has ovarian tissue present are needed for cases with unknown neutering status. Vaginal cytology consistent with heat is indicative of functional ovarian tissue. Other methods are required when the bitch is not presented in suspected heat. Progesterone can be analyzed during 2 months after suspected heat. During other stages, assays for the analyses of anti-Müllerian hormone (AMH) and luteinizing hormone (LH) have been used. The AMH assay is expected to give detectable concentrations (positive) in bitches with ovarian tissue, and the LH assay should give negative results in intact bitches, except during the pre-ovulatory LH peak...
September 27, 2017: Theriogenology
https://www.readbyqxmd.com/read/29027670/chiari-like-malformation-in-two-cats
#17
S Minato, M Baroni
Two male, neutered, domestic, shorthaired cats were evaluated for progressive paresis and ataxia. Neurological examinations suggested a spinal cord lesion in each case. Complete blood examination and cerebrospinal fluid analysis were unremarkable in both cats. MRI revealed malformation of the occipital bone with herniation of the cerebellar vermis through the foramen magnum but without syringomyelia. Chiari-like malformation was suspected in both patients. MRI repeated one year later in both cats because of progression of clinical signs yielded the same findings as the initial scans...
October 13, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/28994630/clinical-presentations-treatments-and-risk-factors-for-mortality-in-cats-with-tick-paralysis-caused-by-ixodes-holocyclus-2077-cases-2008-2016
#18
Ellie Leister, John Morton, Rick Atwell, Rob Webster
Objectives The objective of this study was to describe seasonality, demographics, presentations, treatments, complications and outcomes for cats with Ixodes holocyclus causing tick paralysis, and to identify risk factors for mortality. Methods This was a retrospective single cohort study with 2077 cases occurring between 2008 and 2016, and presenting to one of four emergency clinics in south-eastern Queensland, Australia. Case mortality at 5 days post-presentation could be determined for 1742 cases, and potential risk factors for mortality were assessed using random-effects logistic regression...
October 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28993095/comparison-of-the-brainstem-auditory-evoked-responses-during-sevoflurane-or-alfaxalone-anaesthesia-in-adult-cats
#19
Carlos Ros, Carme Soler, Alejandra García de Carellán Mateo
OBJECTIVE: To compare the effects of general anaesthesia using sevoflurane or alfaxalone on the brainstem auditory evoked response (BAER) test in adult healthy cats. STUDY DESIGN: Prospective, clinical, 'blinded', crossover study. ANIMALS: Ten feral adult healthy cats. METHODS: Premedication consisted of dexmedetomidine (0.01 mg kg(-1)) intramuscularly (IM). The first general anaesthesia was induced and maintained with sevoflurane (treatment S) for physical examination, BAER test, complete blood tests, thoracic radiographs and abdominal ultrasound...
March 2, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28984032/effects-of-dietary-selenium-and-moisture-on-the-physical-activity-and-thyroid-axis-of-cats
#20
S E Hooper, R Backus, S Amelon
Consumption of canned cat food is considered a risk factor for the development of feline hyperthyroidism. Because selenium and water are substantially higher in canned diets compared to dry diets, objectives of this study were to determine whether increased dietary selenium or water alters the function of the hypothalamic-pituitary-thyroid axis and leads to an increase in activity level. Employing a 28-day latin square design with a 14-day washout, six lean, neutered male domestic shorthair cats were fed (i) commercially available adult dry feline diet containing 0...
October 6, 2017: Journal of Animal Physiology and Animal Nutrition
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