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Disorders of sexual development

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https://www.readbyqxmd.com/read/29042182/are-endocrine-disrupting-compounds-environmental-risk-factors-for-autism-spectrum-disorder
#1
REVIEW
Amer Moosa, Henry Shu, Tewarit Sarachana, Valerie W Hu
Recent research on the etiology of autism spectrum disorder (ASD) has shifted in part from a singular focus on genetic causes to the involvement of environmental factors and their gene interactions. This shift in focus is a result of the rapidly increasing prevalence of ASD coupled with the incomplete penetrance of this disorder in monozygotic twins. One such area of environmentally focused research is the association of exposures to endocrine disrupting compounds (EDCs) with elevated risk for ASD. EDCs are exogenous chemicals that can alter endogenous hormone activity and homeostasis, thus potentially disrupting the action of sex and other natural hormones at all stages of human development...
October 14, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/29034101/lamotrigine-induced-sexual-dysfunction-and-non-adherence-case-analysis-with-literature-review
#2
Kenneth R Kaufman, Melissa Coluccio, Kartik Sivaraaman, Miriam Campeas
BACKGROUND: Optimal anti-epileptic drug (AED) treatment maximises therapeutic response and minimises adverse effects (AEs). Key to therapeutic AED treatment is adherence. Non-adherence is often related to severity of AEs. Frequently, patients do not spontaneously report, and clinicians do not specifically query, critical AEs that lead to non-adherence, including sexual dysfunction. Sexual dysfunction prevalence in patients with epilepsy ranges from 40 to 70%, often related to AEDs, epilepsy or mood states...
September 2017: BJPsych Open
https://www.readbyqxmd.com/read/29033635/evaluation-of-5-httlpr-gene-polymorphism-and-resilience-components-on-the-development-of-psychopathology-in-adolescent-sexual-abuse-cases
#3
Gresa Çarkaxhiu Bulut, Ayşe Rodopman Arman, İlter Güney, Pınar Gültepe
INTRODUCTION: More than one-fourth adolescents are exposed to unexpected frightening experiences and traumas until adulthood. In this study, we aimed to determine the potential role of serotonin transporter (5-HTT) gene polymorphism regarding resilience factors in the symptom variability of individuals exposed to sexual abuse. METHODS: Adolescents aged 11-17 years, who were admitted to the Marmara University Child Psychiatry Outpatient Clinic Forensic division with sexual abuse experience history, were informed about the research, and volunteers were included in the study...
September 2017: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/29024164/understanding-role-of-steroids-in-typical-and-atypical-brain-development-advantages-of-using-a-brain-in-a-dish-approach
#4
REVIEW
Dwaipayan Adhya, Emily Annuario, Madeline A Lancaster, Jack Price, Simon Baron-Cohen, Deepak P Srivastava
Steroids have an important role in growth, development, sexual differentiation and reproduction. All four classes of steroids, androgens, estrogens, progestogens and glucocorticoids, have varying effects on the brain. Androgens and estrogens are involved in the sexual differentiation of the brain, and also influence cognition. Progestogens such as progesterone and its metabolites have been shown to be involved in neuroprotection, although their protective effects are timing dependent. Glucocorticoids are linked with stress and memory performance, also in a dose- and time-dependent manner...
October 12, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29017066/a-psychometric-evaluation-of-the-posttraumatic-cognitions-inventory-with-veterans-seeking-treatment-following-military-trauma-exposure
#5
Minden B Sexton, Margaret T Davis, Diana C Bennett, David H Morris, Sheila A M Rauch
Trauma-related beliefs have salient relationships to the development and maintenance of Posttraumatic Stress Disorder (PTSD) following stress exposure. The Posttraumatic Cognitions Inventory (PTCI) has the potential to be a standard assessment of this critical construct. However, some critical aspects of validity and reliability appear to vary by population. To date, the PTCI has not been psychometrically evaluated for use with military-specific traumas such as combat and military sexual trauma (MST). Based on exploratory and confirmatory analyses with 949 Veterans seeking trauma-focused treatment for military traumas, we found a four factor model (negative view of the self, negative view of the world, self-blame, and negative beliefs about coping competence) provided the best fit...
September 27, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29016793/mining-100-million-notes-to-find-homelessness-and-adverse-childhood-experiences-2-case-studies-of-rare-and-severe-social-determinants-of-health-in-electronic-health-records
#6
Cosmin A Bejan, John Angiolillo, Douglas Conway, Robertson Nash, Jana K Shirey-Rice, Loren Lipworth, Robert M Cronin, Jill Pulley, Sunil Kripalani, Shari Barkin, Kevin B Johnson, Joshua C Denny
Objective: Understanding how to identify the social determinants of health from electronic health records (EHRs) could provide important insights to understand health or disease outcomes. We developed a methodology to capture 2 rare and severe social determinants of health, homelessness and adverse childhood experiences (ACEs), from a large EHR repository. Materials and Methods: We first constructed lexicons to capture homelessness and ACE phenotypic profiles. We employed word2vec and lexical associations to mine homelessness-related words...
July 8, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28993148/the-sexual-event-diary-sed-development-and-validation-of-a-standardized-questionnaire-for-assessing-female-sexual-functioning-during-discrete-sexual-events
#7
Yvonne van Nes, Jos Bloemers, Peter G M van der Heijden, Kim van Rooij, Jeroen Gerritsen, Rob Kessels, Leonard DeRogatis, Adriaan Tuiten
BACKGROUND: The efficacy of on-demand drugs for hypoactive sexual desire disorder (HSDD) or female sexual interest/arousal disorder (FSIAD) should be assessed using a validated instrument that assesses the discrete sexual events during which the on-demand drug is taken. AIM: To develop and validate an event log for measuring sexual satisfaction and sexual functioning of discrete sexual events. METHODS: Psychometric assessment was carried out on data of 10,959 Sexual Event Diaries (SEDs) collected during three clinical trials in a total of 421 women with HSDD...
October 6, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28993093/hypersexual-disorder-according-to-the-hypersexual-disorder-screening-inventory-in-help-seeking-swedish-men-and-women-with-self-identified-hypersexual-behavior
#8
Katarina Görts Öberg, Jonas Hallberg, Viktor Kaldo, Cecilia Dhejne, Stefan Arver
INTRODUCTION: The Hypersexual Disorder Screening Inventory (HDSI) was developed by the American Psychiatric Association for clinical screening of hypersexual disorder (HD). AIMS: To examine the distribution of the proposed diagnostic entity HD according to the HDSI in a sample of men and women seeking help for problematic hypersexuality and evaluate some psychometric properties. METHODS: Data on sociodemographics, the HDSI, the Sexual Compulsivity Scale (SCS), and the Cognitive and Behavioral Outcomes of Sexual Behavior were collected online from 16 women and 64 men who self-identified as hypersexual...
October 6, 2017: Sexual Medicine
https://www.readbyqxmd.com/read/28974386/sex-differences-in-parkinson%C3%AC-s-disease-features-on-clinical-symptoms-treatment-outcome-sexual-hormones-and-genetics
#9
REVIEW
Juan Camilo Jurado-Coronel, Ricardo Cabezas, Marco Fidel Ávila Rodríguez, Valentina Echeverría, Luis Miguel García-Segura, George E Barreto
Parkinson's disease (PD) is the second most frequent age-related neurodegenerative disorder. Sex is an important factor in the development of PD, as reflected by the fact that it is more common in men than in women by an approximate ratio of 2:1. Our hypothesis is that differences in PD among men and women are highly determined by sex-dependent differences in the nigrostriatal dopaminergic system, which arise from environmental, hormonal and genetic influences. Sex hormones, specifically estrogens, influence PD pathogenesis and might play an important role in PD differences between men and women...
September 30, 2017: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/28972706/trauma-informed-care-survey-of-psychiatrists-and-primary-care-physicians-in-the-middle-east
#10
Ossama T Osman, Laeth Nasir, Richard F Mollica, Taoufik Zoubeidi, James Lavelle, Noor Amawi
Objective: To explore in Arab communities the prevalence, dynamics, and resources available to address the physical and psychological consequences that may arise from psychiatric disorders. Methods: An online survey of psychiatrists and primary care physicians from 17 Arab countries was conducted between September 2011 and June 2012. The survey serves as a needs assessment in a scientifically valid and culturally sensitive manner. Additionally, it focuses attention on the clinical strengths and weaknesses of Middle Eastern primary health care and mental health centers in identifying and treating trauma-related health and mental health issues...
September 28, 2017: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/28962900/effects-of-tamoxifen-on-neuronal-morphology-connectivity-and-biochemistry-of-hypothalamic-ventromedial-neurons-impact-on-the-modulators-of-sexual-behavior
#11
Susana I Sá, Natércia Teixeira, Bruno M Fonseca
Tamoxifen (TAM) is a selective estrogen receptor modulator, widely used in the treatment and prevention of estrogen-dependent breast cancer. Although with great clinical results, women on TAM therapy still report several side effects, such as sexual dysfunction, which impairs quality of life. The anatomo-functional substrates of the human sexual behavior are still unknown; however, these same substrates are very well characterized in the rodent female sexual behavior, which has advantage of being a very simple reflexive response, dependent on the activation of estrogen receptors (ERs) in the ventrolateral division of the hypothalamic ventromedial nucleus (VMNvl)...
September 28, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28953126/development-and-psychometric-testing-of-an-electronic-patient-reported-outcome-tool-for-vulval-disorders-epaq-vulva
#12
Thomas G Gray, Charlotte Alexander, Georgina L Jones, John A Tidy, Julia E Palmer, Stephen C Radley
OBJECTIVE: Development of an electronic patient-reported outcome measure (PROM) specifically designed for vulval disorders. Psychometric testing of the components of the questionnaire, which assess vulval symptoms, sexual function, and quality of life (QoL). MATERIALS AND METHOD: Development and programming of the instrument (ePAQ-Vulva) was informed by national guidelines for the assessment of vulval disorders, an expert panel, and a survey of 61 vulval clinic patients...
October 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28948447/gender-by-dasein-a-heideggerian-critique-of-suzanne-kessler-and-the-medical-management-of-infants-born-with-disorders-of-sexual-development
#13
Lauren L Baker
This article explores the relationship between gender, technology, language, and how infants and children born with disorders of sexual development are shaped into intelligible members of the community. The contemporary medical model maintains that children ought to be both socially and surgically assigned and reared as one particular gender. Gender scholar Suzanne Kessler rejects this position and argues for the acceptance of greater genital variability through the use of language. Using a Heideggerian lens, the main question I seek to answer in this article is: does Kessler's approach succeed in its aim to better treat individuals born with disorders of sexual development? I argue that Kessler is successful in offering practical solutions for persons with intersexed conditions to exist and flourish as intelligible members of the community, but that her project ultimately relies on power to "challenge forth" greater acceptance of genital variance...
September 25, 2017: Theoretical Medicine and Bioethics
https://www.readbyqxmd.com/read/28942057/psychosocial-symptoms-in-very-young-children-assessed-for-sexual-abuse-a-qualitative-analysis-from-the-asac-study
#14
T F Vrolijk-Bosschaart, S N Brilleslijper-Kater, G A M Widdershoven, A H Teeuw, E Verlinden, Y Voskes, E M van Duin, A P Verhoeff, M de Leeuw, M J Roskam, M A Benninga, R J L Lindauer
Child sexual abuse (CSA) is a worldwide problem with serious consequences. No recognizable symptom pattern for suspected CSA has yet been identified in very young children. We aim to investigate psychosocial symptoms in a sample of children with confirmed or strongly suspected CSA and the interpretations given to such symptoms by independent clinical experts. Secondly we examined whether experts were able to identify confirmed victims of severe CSA. A qualitative study including inductive content analysis of medical files and focus group discussions with independent experts on the interpretation of psychosocial symptoms was conducted...
September 20, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28939807/a-single-dose-live-attenuated-vaccine-prevents-zika-virus-pregnancy-transmission-and-testis-damage
#15
Chao Shan, Antonio E Muruato, Brett W Jagger, Justin Richner, Bruno T D Nunes, Daniele B A Medeiros, Xuping Xie, Jannyce G C Nunes, Kaitlyn M Morabito, Wing-Pui Kong, Theodore C Pierson, Alan D Barrett, Scott C Weaver, Shannan L Rossi, Pedro F C Vasconcelos, Barney S Graham, Michael S Diamond, Pei-Yong Shi
Zika virus infection during pregnancy can cause congenital abnormities or fetal demise. The persistence of Zika virus in the male reproductive system poses a risk of sexual transmission. Here we demonstrate that live-attenuated Zika virus vaccine candidates containing deletions in the 3' untranslated region of the Zika virus genome (ZIKV-3'UTR-LAV) prevent viral transmission during pregnancy and testis damage in mice, as well as infection of nonhuman primates. After a single-dose vaccination, pregnant mice challenged with Zika virus at embryonic day 6 and evaluated at embryonic day 13 show markedly diminished levels of viral RNA in maternal, placental, and fetal tissues...
September 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/28924683/cancer-survivorship-in-adults
#16
Cecilie E Kiserud, Alv A Dahl, Sophie D Fosså
With the favorable trend regarding survival of cancer in the Western world, there is an increasing focus among patients, clinicians, researchers, and politicians regarding cancer survivors' health and well-being. The number of survivors grows rapidly, and more than 3% of the adult populations in Western countries have survived cancer for 5 years or more. Cancer survivors are at increased risk for a variety of late effects after treatment, some life-threatening such as secondary cancer and cardiac diseases, while others mainly have negative impact on daily functioning and health-related quality of life (HRQOL)...
2018: Recent Results in Cancer Research
https://www.readbyqxmd.com/read/28923310/factors-associated-with-specific-diagnostic-and-statistical-manual-of-mental-disorders-fourth-edition-sexual-dysfunctions-in-breast-cancer-survivors-a-study-of-patients-and-their-partners
#17
Susanna B Hummel, Daniela E E Hahn, Jacques J D M van Lankveld, Hester S A Oldenburg, Eva Broomans, Neil K Aaronson
BACKGROUND: Many women develop sexual problems after breast cancer (BC) treatment. Little is known about BC survivors with a Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) sexual dysfunction and their partners, and the factors associated with their sexual functioning. AIM: To evaluate (i) patient-related and clinical factors associated with (a) specific DSM-IV sexual dysfunctions and (b) level of sexual functioning and sexual distress as reported by BC survivors and (ii) the association between the sexual functioning of BC survivors and that of their partners...
October 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28922735/assessing-the-interplay-of-childhood-adversities-with-more-recent-stressful-life-events-and-conditions-in-predicting-panic-pathology-among-adults-from-the-general-population
#18
E Asselmann, J Stender, H J Grabe, J König, C O Schmidt, A O Hamm, C A Pané-Farré
BACKGROUND: Although research suggests that (a) childhood adversities and more recent stressful life events/conditions are risk factors for panic pathology and that (b) early life stress increases vulnerability to later psychopathology, it remains unclear whether childhood adversities amplify the association between more recent stressful life events/conditions and panic pathology. METHODS: Data were derived from a general population sample (Study of Health in Pomerania, SHIP)...
January 1, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28914080/gender-identity-and-sexual-orientation-in-autism-spectrum-disorder
#19
Rita George, Mark A Stokes
Clinical impressions indicate that there is an overrepresentation of gender-dysphoria within the autism spectrum disorder. However, little is presently known about the demographics of gender-identity issues in autism spectrum disorder. Based upon what little is known, we hypothesized that there would be an increased prevalence of gender-dysphoria among those with autism spectrum disorder compared to a typically developing population. We surveyed gender-dysphoria with the Gender-Identity/Gender-Dysphoria Questionnaire among 90 males and 219 females with autism spectrum disorder and compared these rates to those of 103 males and 158 females without autism spectrum disorder...
September 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/28913116/evaluation-of-sleep-disorder-and-its-effect-on-sexual-dysfunction-in-patients-with-fibromyalgia-syndrome
#20
Tuba Tülay Koca, Günseli Karaca Acet, Emrullah Tanrıkut, Burcu Talu
OBJECTIVE: Sexual problems are commonly seen in women with fibromyalgia syndrome (FMS). The objective of this study was to reveal the relationship between the severity of symptoms, sleep disorder, and sexual dysfunction in women with FMS. MATERIALS AND METHODS: A total of 140 sexually active women with FMS aged 17-67 years who presented to our physical medicine and rehabilitation outpatient clinic between January 2016 and June 2016 were enrolled in the study. The patients' age, height, body weight, body mass index (BMI), and general pain score [visual analogue scale, (VAS)] for the last 1 week were recorded...
December 2016: Turk J Obstet Gynecol
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