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Disorders of sexual development

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https://www.readbyqxmd.com/read/29451224/hypogonadism-in-male-thalassemia-major-patients-pathophysiology-diagnosis-and-treatment
#1
Vincenzo De Sanctis, Ashraf T Soliman, Mohamed A Yassin, Salvatore Di Maio, Shahina Daar, Heba Elsedfy, Nada Soliman, Christos Kattamis
Failure of pubertal growth, delay or absence of sexual development, infertility and sexual dysfunction due to hypogonadism and defective spermatogenesis are frequent and well recognized disturbances among male patients with transfusion dependent (TD) thalassaemia major (β-thal). These problems are attributed mainly to the damage caused by chronic anaemia and the deposition of excess iron in the pituitary gland and testicles. This is a short review of male pubertal disorders in patients with β-thal written by pediatric endocrinologists and haematologists with an interest and active involvement, in the diagnosis and management of these complications in this group of patients...
February 16, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29450222/mood-changes-after-watching-pornography-on-the-internet-are-linked-to-tendencies-towards-internet-pornography-viewing-disorder
#2
Christian Laier, Matthias Brand
Internet-pornography-viewing disorder (IPD) is considered one type of Internet-use disorder. For IPD's development, it was assumed theoretically that a dysfunctional use of Internet pornography to cope with depressive mood or stress might be considered to be a risk factor. To address the effect of Internet pornography use on mood, an online study with three measuring points with a sample of male participants was conducted. Participants were investigated regarding their tendencies towards IPD, personal use of Internet pornography, general mood, perceived stress, and their Internet pornography use motivation...
June 2017: Addictive Behaviors Reports
https://www.readbyqxmd.com/read/29441607/an-international-urogynecological-association-iuga-international-continence-society-ics-joint-report-on-the-terminology-for-the-assessment-of-sexual-health-of-women-with-pelvic-floor-dysfunction
#3
Rebecca G Rogers, Rachel N Pauls, Ranee Thakar, Melanie Morin, Annette Kuhn, Eckhard Petri, Brigitte Fatton, Kristene Whitmore, Sheryl Kinsberg, Joseph Lee
AIMS: The terminology in current use for sexual function and dysfunction in women with pelvic floor disorders lacks uniformity, which leads to uncertainty, confusion, and unintended ambiguity. The terminology for the sexual health of women with pelvic floor dysfunction needs to be collated in a clinically-based consensus report. METHODS: This report combines the input of members of the Standardization and Terminology Committees of two International Organizations, the International Urogynecological Association (IUGA), and the International Continence Society (ICS), assisted at intervals by many external referees...
February 14, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29428123/innovations-reviews-and-proposals-on-the-dsm-5-the-case-of-sexual-dysfunctions-gender-dysphoria-and-paraphilic-disorders
#4
Adalberto Campo-Arias, Edwin Herazo
Human behaviours have different meanings according to the historical moment and context. In this article sexual behaviours are taken as a category in order to analyse how psychiatric nosology is structured, as manifested in texts such as the DSM-5. The development of these diagnostic manuals are tools that are far from being free of subjectivities and interference of elements of power, expressed in the way health, illness, mental health, and mental disorders, are assumed; in short, the normal and pathological...
January 2018: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/29422006/inhibition-of-neurogenesis-by-zika-virus-infection
#5
Fahim Ahmad, Amna Siddiqui, Mohammad A Kamal, Sayed S Sohrab
The association between Zika virus infection and neurological disorder has raised urgent global alarm. The ongoing epidemic has triggered quick responses in the scientific community. The first case of Zika virus was reported in 2015 from Brazil and now has spread over 30 countries. Nearly four hundred cases of travel-associated Zika virus infection have also been reported in the United States. Zika virus is primarily transmitted by mosquito belongs to the genus Aedes that are widely distributed throughout the world including the Southern United States...
February 1, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29411347/child-sexual-abuse-as-an-etiological-factor-of-overweight-and-eating-disorders-considerations-for-primary-health-care-providers
#6
Justyna Opydo-Szymaczek, Grażyna Jarząbek-Bielecka, Witold Kędzia, Maria Borysewicz-Lewicka
Despite the recognition of the clinical importance of child sexual abuse, primary health care providers are often not ad-equately prepared to perform medical evaluations and diagnose child sexual maltreatment. Paper presents basic symptoms and signs of CSA, which may suggest the need for further patient's diagnosis and referral. Since the great majority of sexually abused children do not have any abnormal physical findings, special attention is paid to the silent warning signs of CSA, such as changes in attitude towards own body and eating habits...
2018: Ginekologia Polska
https://www.readbyqxmd.com/read/29407872/early-postnatal-treatment-with-clomipramine-induces-female-sexual-behavior-and-estrous-cycle-impairment
#7
Tania Molina-Jiménez, Ofelia Limón-Morales, Herlinda Bonilla-Jaime
Administration of clomipramine (CMI), a tricyclic antidepressant, in early stages of development in rats, is considered an animal model for the study of depression. This pharmacological manipulation has induced behavioral and physiological alterations, i.e., less pleasure-seeking behaviors, despair, hyperactivity, cognitive dysfunction, alterations in neurotransmitter systems and in HPA axis. These abnormalities in adult male rats are similar to the symptoms observed in major depressive disorders. One of the main pleasure-seeking behaviors affected in male rats treated with CMI is sexual behavior...
January 31, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29407563/affective-temperaments-play-an-important-role-in-the-relationship-between-child-abuse-and-the-diagnosis-of-bipolar-disorder
#8
Hiroyuki Toda, Takeshi Inoue, Masaaki Tanichi, Taku Saito, Shin Nakagawa, Jiro Masuya, Hajime Tanabe, Aihide Yoshino, Ichiro Kusumi
In previous studies, various components such as environmental and genetic factors have been shown to contribute to the development of bipolar disorder (BD). This study investigated how multiple factors, including child abuse, adult life events, and affective temperaments, are interrelated and how they affect the diagnosis of BD. A total of 170 healthy controls and 75 BD patients completed the following self-administered questionnaires: the Patient Health Questionnaire-9 evaluating the severity of depressive symptoms; the Child Abuse and Trauma Scale (CATS) evaluating child abuse; the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego autoquestionnaire (TEMPS-A) evaluating affective temperaments; and the Life Experiences Survey (LES) evaluating negative and positive adult life events...
January 29, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29398933/sexuality-in-autism-hypersexual-and-paraphilic-behavior-in-women-and-men-with-high-functioning-autism-spectrum-disorder
#9
Daniel Schöttle, Peer Briken, Oliver Tüscher, Daniel Turner
Like nonaffected adults, individuals with autism spectrum disorders (ASDs) show the entire range of sexual behaviors. However, due to the core symptoms of the disorder spectrum, including deficits in social skills, sensory hypo- and hypersensitivities, and repetitive behaviors, some ASD individuals might develop quantitatively above-average or nonnormative sexual behaviors and interests. After reviewing the relevant literature on sexuality in high-functioning ASD individuals, we present novel findings on the frequency of normal sexual behaviors and those about the assessment of hypersexual and paraphilic fantasies and behaviors in ASD individuals from our own study...
December 2017: Dialogues in Clinical Neuroscience
https://www.readbyqxmd.com/read/29397445/population-attributable-risk-of-factors-associated-with-the-repetition-of-self-harm-behaviour-in-young-people-presenting-to-clinical-services-a-systematic-review-and-meta-analysis
#10
REVIEW
Katrina Witt, Allison Milner, Matthew J Spittal, Sarah Hetrick, Jo Robinson, Jane Pirkis, Gregory Carter
The repetition of hospital-treated self-harm by young people is common. However, little work has summarised the modifiable factors associated with this. A thorough understanding of those factors most strongly associated with repetition could guide the development of relevant clinical interventions. We systematically reviewed four databases (EMBASE, Medline, PubMed and PsycINFO) until 15 April 2016 to identify all observational studies of factors for the repetition of self-harm or suicide reattempts (together referred to as 'self-harm behaviour') in young people...
February 3, 2018: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29397027/hereditary-palmoplantar-keratodermas-part-ii-syndromic-palmoplantar-keratodermas-diagnostic-algorithm-and-principles-of-therapy
#11
REVIEW
L Guerra, M Castori, B Didona, D Castiglia, G Zambruno
Hereditary palmoplantar keratodermas (PPKs) comprise a large and heterogeneous group of disorders characterized by persistent thickening of the epidermis at palmar and plantar surfaces. Clinical and genetic features of isolated and complex PPKs have been reviewed in part I of this 2-part review. Here we focus on clinical and molecular classification of syndromic PPKs which are recognized by additional extracutaneous manifestations, in particular deafness, specific mucosal lesions, cardiomyopathy, inborn errors of metabolism, involvement of internal organs or disorders of sexual development...
February 3, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29393271/phenotypic-variation-in-46-xx-disorders-of-sex-development-due-to-the-nr5a1-p-r92w-variant-a-sibling-case-report-and-literature-review
#12
Kei Takasawa, Maki Igarashi, Makoto Ono, Akira Takemoto, Shuji Takada, Atsuyuki Yamataka, Tsutomu Ogata, Tomohiro Morio, Maki Fukami, Kenichi Kashimada
Recently, a heterozygous missense mutation in NR5A1, p.R92W, was identified as a cause of 46,XX testicular/ovo-testicular disorders of sexual development (DSD). We report a sibling pair with 46,XX DSD due to an NR5A1 mutation with distinct phenotypes, including external and internal genitalia and gonads, for whom different rearing sexes were selected. Thus, the phenotypes of p.R92W vary, even within a family. The father of the patients showed oligozoospermia with the p.R92W mutation, suggesting that in 46,XY individuals, the mutation would cause various gonadal phenotypes...
January 24, 2018: Sexual Development: Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation
https://www.readbyqxmd.com/read/29389211/hypersexuality-associated-with-paliperidone-a-case-report
#13
Ali Çayköylü, Ersin Hatice Karslıoğlu, İbrahim Özer, Ali Gökberk Köksal
We report a case of unusual sexual symptoms in a 43-year-old female patient with schizophrenia (according to Diagnostic and Statistical Manual of Mental Disorders, fifth edition), who was being treated with a depot formulation of paliperidone palmitate, an atypical antipsychotic medication. The symptoms included increased sexual desire, sexual preoccupation, constant drive for intercourse, and sexual arousal with unrelated stimuli such as urination. Potential neurochemical mechanisms have been elucidated for this symptomatology...
February 1, 2018: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29380696/kisspeptin-and-its-effect-on-mammalian-spermatogensis
#14
Tao Feng, Jiahua Bai, Xiaoling Xu, Yan Liu
Kisspeptin and its receptor, GPR54, are regarded as key regulators of and catalysts for male puberty onset, and also fundamental gatekeepers of spermatogenesis in mammals. Consequently, the loss function of kisspeptin or GPR54 leads to a symptom of hypogonadotropic hypogonadism (HH) in human and HH accompanied by lower gonadotrophic hormone levels, smaller testes, impaired spermatogenesis and abnormal sexual maturation in mice. Besides its well- recognized functions in hypothalamus before and during puberty, accumulating data strongly support kisspeptin production in tests, and participation in somatic and germ cell development and sperm functions as well...
January 28, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29374087/food-restriction-but-not-fish-oil-increases-fertility-in-hens-role-of-rarres2
#15
Namya Mellouk, Christelle Ramé, Joël Delaveau, Christophe Rat, Maxime Marchand, Frederic Mercerand, Angelique Travel, Aurelien Brionne, Pascal Chartrin, LinLin Ma, Pascal Froment, Joëlle Dupont
Overfed hens selected for their rapid growth become fatter and develop reproductive disorders. Herein, we aimed to demonstrate that food restriction leading to a weight reduction and/or a supplementation with fish oil may be effective in preventing reproductive disorders through the regulation of adipokine expression in broiler hens. This study included four groups of food restricted (Rt) or ad libitum hens (Ad, feeding at a rate 1.7 times greater than Rt hens) supplemented or unsupplemented with fish oil (1%)...
January 26, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29371146/couplepause-a-new-paradigm-in-treating-sexual-dysfunction-during-menopause-and-andropause
#16
REVIEW
Emmanuele A Jannini, Rossella E Nappi
BACKGROUND: At midlife and beyond, both men and women face organic changes that can affect sexual functioning. For women, ovarian exhaustion causes estrogen deficiency, leading to genitourinary syndrome of menopause, which may include vaginal dryness, irritation/itching, inadequate lubrication, and dyspareunia. Hypoactive sexual desire disorder also can result from biopsychosocial factors. For men, erectile dysfunction prevalence increases with age, and some men develop testosterone deficiency...
January 19, 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29371145/assessment-of-sexual-desire-for-clinical-trials-of-women-with-hypoactive-sexual-desire-disorder-measures-desire-related-behavior-and-assessment-of-clinical-significance
#17
REVIEW
Robert E Pyke, Anita H Clayton
BACKGROUND: The Female Sexual Function Index-desire subscale is the standard measure for clinical trials of hypoactive sexual desire disorder (HSDD), but lacks items assessing sexually related behaviors and attitudes toward partner. Counting satisfying sexual events is criticized, but sexual behavior remains important. Mean treatment differences cannot define clinical significance; responder and remitter analyses help. We reviewed measures on sexual desire and sexual behavior relevant to HSDD, and how to assess clinical significance...
January 19, 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29366859/endogenous-opiates-and-behavior-2016
#18
REVIEW
Richard J Bodnar
This paper is the thirty-ninth consecutive installment of the annual review of research concerning the endogenous opioid system. It summarizes papers published during 2016 that studied the behavioral effects of molecular, pharmacological and genetic manipulation of opioid peptides, opioid receptors, opioid agonists and opioid antagonists. The particular topics that continue to be covered include the molecular-biochemical effects and neurochemical localization studies of endogenous opioids and their receptors related to behavior, and the roles of these opioid peptides and receptors in pain and analgesia, stress and social status, tolerance and dependence, learning and memory, eating and drinking, drug abuse and alcohol, sexual activity and hormones, pregnancy, development and endocrinology, mental illness and mood, seizures and neurologic disorders, electrical-related activity and neurophysiology, general activity and locomotion, gastrointestinal, renal and hepatic functions, cardiovascular responses, respiration and thermoregulation, and immunological responses...
January 20, 2018: Peptides
https://www.readbyqxmd.com/read/29366416/finasteride-topical-delivery-systems-for-androgenetic-alopecia
#19
Muhammad Zia Ullah Khan, Shujaat Ali Khan, Muhammad Ubaid, Aamna Shah, Rozina Kousar, Ghulam Murtaza
Androgenetic alopecia, generally recognized as male pattern baldness, is a gradually developing medical and physiological change, which is manifested by continuous hair-loss from scalp. Finasteride (4-aza-3-oxosteroid) is a potent anti-baldness compound that selectively and competitively inhibits the 5α-reductase isoenzymes. Prolonged oral use of finasteride leads to the emergence of sexual disorders including decrease in libido, gynecomastia, erectile dysfunction, ejaculation disorder, orgasm disorders and mood disturbances...
January 23, 2018: Current Drug Delivery
https://www.readbyqxmd.com/read/29362955/a-quantitative-analysis-of-mental-health-among-sexual-and-gender-minority-groups-in-asd
#20
Rita George, Mark A Stokes
There is increased mental-health adversity among individuals with autism spectrum disorder. At the same time, sexual and gender minority groups experience poorer mental-health when compared to heteronormative populations. Recent research suggests that autistic individuals report increased non-heterosexuality and gender-dysphoric traits. The current study aimed to investigate whether as membership of minority grouping becomes increasingly narrowed, mental health worsened. The present study compared the rates of depression, anxiety, and stress using the DASS-21 and Personal Well-Being using the personal well-being index between 261 typically-developing individuals and 309 autistic individuals...
January 23, 2018: Journal of Autism and Developmental Disorders
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