Naoya Kasahara, Takumi Teratani, Shinichiro Yokota, Yasunaru Sakuma, Hideki Sasanuma, Yasuhiro Fujimoto, Tetsuo Ijichi, Taizen Urahashi, Hideyuki Yoshitomi, Joji Kitayama, Naohiro Sata
Intestinal adaptation does not necessarily recover absorptive capacity in short bowel syndrome (SBS), sometimes resulting in intestinal failure-associated liver disease (IFALD). Additionally, its therapeutic options remain limited. Polyamines (spermidine and spermine) are known as one of the autophagy inducers and play important roles in promoting the weaning process; however, their impact on intestinal adaptation is unknown. The aim of this study was to investigate the impact of polyamines ingestion on adaptation and hepatic lipid metabolism in SBS...
February 26, 2024: Scientific Reports