L A Decosterd, T Mercier, B Ternon, S Cruchon, N Guignard, S Lahrichi, B Pesse, B Rochat, R Burger, F Lamoth, J-L Pagani, P Eggimann, C Csajka, E Choong, T Buclin, N Widmer, P André, O Marchetti
OBJECTIVE: Unpredictable pharmacokinetics of antibiotics in patients with life-threatening bacterial infections is associated with drug under- or overdosing. Therapeutic drug monitoring (TDM) may guide dosing adjustment aimed at maximizing antibacterial efficacy and minimizing toxicity. Rapid and accurate analytical methods are key for real-time TDM. Our objective was to develop a robust high-performance liquid chromatography-tandem mass spectrometry method (HPLC-MS/MS) for multiplex quantification of plasma concentrations of 12 antibiotics: imipenem/cilastatin, meropenem, ertapenem, cefepime, ceftazidime, ceftriaxone, piperacillin/tazobactam, amoxicillin, flucloxacillin, rifampicin, daptomycin...
November 10, 2020: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences