Lei Zhang, Anna Evans, Chris von Ruhland, Mohd Shazli Draman, Sarah Edkins, Amy E Vincent, Rolando Berlinguer-Palmini, D Aled Rees, Anjana S Haridas, Dan Morris, Andrew R Tee, Marian Ludgate, Doug M Turnbull, Fredrik Karpe, Colin M Dayan
Depot specific expansion of orbital-adipose-tissue (OAT) in Graves' Orbitopathy (GO) is associated with lipid metabolism signaling defects. We hypothesize that the unique adipocyte biology of OAT facilitates its expansion in GO. A comprehensive comparison of OAT and white-adipose-tissue (WAT) was performed by light/electron-microscopy, lipidomic and transcriptional analysis using ex vivo WAT, healthy OAT (OAT-H) and OAT from GO (OAT-GO). OAT-H/OAT-GO have a single lipid-vacuole and low mitochondrial number...
November 30, 2020: International Journal of Molecular Sciences