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https://www.readbyqxmd.com/read/29331711/omega-3-supplements-reduce-self-reported-physical-aggression-in-healthy-adults
#1
Laurent Bègue, Ap Zaalberg, Rébecca Shankland, Aaron Duke, Julie Jacquet, Perla Kaliman, Lucie Pennel, Marc Chanove, Philippe Arvers, Brad J Bushman
There is emerging evidence that Omega-3 polyunsaturated fatty acids (PUFA) supplements can decrease aggression. However, experimental studies with adults from non-specific populations are scarce. We hypothesized that Omega-3 supplements would decrease self-reported aggression among non-clinical participants. In a double-blind randomized trial, two groups of participants (N = 194) aged 18-45 from the general population followed a 6-weeks treatment with 638mg docosahexaenoic acid (DHA) and 772mg eicosapentaenoic acid (EPA) per day or the equivalent quantity of copra oil (placebo)...
December 15, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29331380/eicosapentaenoic-acid-inhibits-oxidation-of-high-density-lipoprotein-particles-in-a-manner-distinct-from-docosahexaenoic-acid
#2
Samuel C R Sherratt, R Preston Mason
The omega-3 fatty acid eicosapentaenoic acid (EPA) reduces oxidation of ApoB-containing particles in vitro and in patients with hypertriglyceridemia. EPA may produce these effects through a potent antioxidant mechanism, which may facilitate LDL clearance and slow plaque progression. We hypothesize that EPA antioxidant effects may extend to ApoA-containing particles like HDL, potentially preserving certain atheroprotective functions. HDL was isolated from human plasma and incubated at 37 °C in the absence (vehicle) or presence of EPA and/or DHA; 5...
January 10, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29316682/effect-of-omega-3-fatty-acid-supplementation-on-oxylipins-in-a-routine-clinical-setting
#3
Christoph Schmöcker, Ingrid W Zhang, Stefanie Kiesler, Ursula Kassner, Annika I Ostermann, Elisabeth Steinhagen-Thiessen, Nils H Schebb, Karsten-H Weylandt
Omega-6 polyunsaturated fatty acid (n-6 PUFA) is the predominant polyunsaturated fatty acid (PUFA), especially in Western diet. A high omega-6/omega-3 ratio in Western diets is implicated in the development of cardiovascular diseases and inflammatory processes. Studies in animal models and in humans have demonstrated beneficial effects of omega-3 PUFA (n-3 PUFA) in a variety of diseases, including cardiac arrhythmias and inflammatory diseases, as well as breast and colon cancer. The molecular mechanisms underlying the effects of n-3 PUFA are still not well understood...
January 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29306138/spatial-and-length-dependent-variation-of-the-risks-and-benefits-of-consuming-walleye-sander-vitreus
#4
Ursula Strandberg, Satyendra P Bhavsar, Tarn Preet Parmar, Michael T Arts
Restricted fish consumption due to elevated contaminant levels may limit the intake of essential omega-3 fatty acids, such as eicosapentaenoic (EPA; 20:5n-3) and docosahexaenoic (DHA; 22:6n-3) acids. We analyzed lake- and length-specific mercury and EPA+DHA contents in Walleye (Sander vitreus; Mitchell 1818) from 20 waterbodies in Ontario, Canada, and used this information to calculate the theoretical intake of EPA+DHA when the consumption advisories are followed. The stringent consumption advisory resulted in decreased EPA+DHA intake regardless of the EPA+DHA content in Walleye...
January 2, 2018: Environment International
https://www.readbyqxmd.com/read/29305832/all-n-3-pufa-are-not-the-same-md-simulations-reveal-differences-in-membrane-organization-for-epa-dha-and-dpa
#5
Xiaoling Leng, Jacob J Kinnun, Andres T Cavazos, Samuel W Canner, Saame Raza Shaikh, Scott E Feller, Stephen R Wassall
Eicosapentaenoic (EPA, 20:5), docosahexaenoic (DHA, 22:6) and docosapentaenoic (DPA, 22:5) acids are omega-3 polyunsaturated fatty acids (n-3 PUFA) obtained from dietary consumption of fish oils that potentially alleviate the symptoms of a range of chronic diseases. We focus here on the plasma membrane as a site of action and investigate how they affect molecular organization when taken up into a phospholipid. All atom MD simulations were performed to compare 1-stearoyl-2-eicosapentaenoylphosphatylcholine (EPA-PC, 18:0-20:5PC), 1-stearoyl-2-docosahexaenoylphosphatylcholine (DHA-PC, 18:0-22:6PC), 1-stearoyl-2-docosapentaenoylphosphatylcholine (DPA-PC, 18:0-22:5PC) and, as a monounsaturated control, 1-stearoyl-2-oleoylphosphatidylcholine (OA-PC, 18:0-18:1PC) bilayers...
January 3, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29304057/long-chain-omega-3-polyunsaturated-fatty-acid-dietary-intake-is-positively-associated-with-bone-mineral-density-in-normal-and-osteopenic-spanish-women
#6
Jesus Lavado-García, Raul Roncero-Martin, Jose M Moran, Maria Pedrera-Canal, Ignacio Aliaga, Olga Leal-Hernandez, Sergio Rico-Martin, Maria L Canal-Macias
The regular consumption of long-chain omega-3 polyunsaturated fatty acids (LCO3-PUFAs) results in general health benefits. The intake of LCO3-PUFAs has been reported to contribute to bone metabolism. We aimed to investigate the relationships between dietary intakes of LCO3-PUFAs and bone mineral density (BMD) in Spanish women aged 20-79 years old. A total of 1865 female subjects (20-79 years old) were enrolled, and lumbar (L2, L3, L3 and total spine), hip (femoral neck (FN), femoral trochanter (FT) and Ward's triangle (WT)) bone mineral density (BMD) were measured by dual energy X-ray absorptiometry (DXA)...
2018: PloS One
https://www.readbyqxmd.com/read/29302857/combination-of-omega-3-fatty-acids-and-valproic-acid-in-treatment-of-borderline-personality-disorder-a-follow-up-study
#7
Paola Bozzatello, Paola Rocca, Silvio Bellino
BACKGROUND AND OBJECTIVES: Some evidence of efficacy has been found for omega-3 fatty acids in patients with borderline personality disorder (BPD). In a previous 12-week randomized trial we assessed the efficacy of the combination of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) with valproic acid, in comparison with valproic acid monotherapy, in 43 BPD outpatients. Combined therapy was superior to valproic acid monotherapy (the control group) in the treatment of some BPD symptoms: impulsive-behavioral dyscontrol, outbursts of anger, and self-harm...
January 5, 2018: Clinical Drug Investigation
https://www.readbyqxmd.com/read/29287405/direct-infusion-mass-spectrometric-identification-of-molecular-species-of-glycerophospholipid-in-three-species-of-edible-whelk-from-yellow-sea
#8
Kai-Qi Gang, Da-Yong Zhou, Ting Lu, Zhong-Yuan Liu, Qi Zhao, Hong-Kai Xie, Liang Song, Fereidoon Shahidi
Whelk has been exploited commercially as a delicacy for a long time. Although previous studies have suggested that whelk might serve as a potential rich source of long chain omega-3 polyunsaturated fatty acids (n-3 LC-PUFA) enriched phospholipid (PL), the molecular species profile of the PL have not been reported yet. In this study, more than 220 molecular species of glycerophospholipid (GP) belonging to eight classes including glycerophosphocholine, glycerophosphoethanolamine, glycerophosphoserine, glycerophosphoinositol, lysoglycerophosphocholine, lysoglycerophosphoethanolamine, lysoglycerophosphoserine and lysoglycerophosphoinositol in three species of edible whelks (Buccinium yokomaruae, Neptunea arthritica cumingi Cosse and Volutharpa ampullaceal) were identified for the first time by using direct infusion tandem mass spectrometric method...
April 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29284786/effect-of-omega-3-long-chain-polyunsaturated-fatty-acid-supplementation-on-heart-rate-a-meta-analysis-of-randomized-controlled-trials
#9
REVIEW
Khemayanto Hidayat, Jing Yang, Zheng Zhang, Guo-Chong Chen, Li-Qiang Qin, Manfred Eggersdorfer, Weiguo Zhang
BACKGROUND: Elevated resting heart rate (HR) has emerged as a new risk factor for all-cause and cardiovascular mortality. The effect of marine-derived omega-3 long-chain polyunsaturated fatty acid (n-3 LCPUFAs) supplementation on HR was investigated as an outcome in many clinical trials. The present study was to provide an updated meta-analysis on the HR-slowing effect of n-3 LCPUFAs, and to differentiate the chronotropic effect between eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)...
December 28, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29280361/cardiovascular-disease-and-omega-3s-prescription-products-and-fish-oil-dietary-supplements-are-not-the-same
#10
REVIEW
Adina S Gutstein, Tina Copple
BACKGROUND AND PURPOSE: Despite achievement of optimal low-density lipoprotein cholesterol (LDL-C) control with statin therapy, patients with elevated triglycerides (TGs) and residual cardiovascular risk are commonly encountered in clinical practice. METHODS: We present information from completed and ongoing clinical trials examining Rx omega-3s for TG-lowering and omega-3 dietary supplements to highlight important differences affecting patient management for nurse practitioners...
December 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/29278384/marine-cryptophytes-are-great-sources-of-epa-and-dha
#11
Elina Peltomaa, Matthew D Johnson, Sami J Taipale
Microalgae have the ability to synthetize many compounds, some of which have been recognized as a source of functional ingredients for nutraceuticals with positive health effects. One well-known example is the long-chain polyunsaturated fatty acids (PUFAs), which are essential for human nutrition. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are the two most important long-chain omega-3 (ω-3) PUFAs involved in human physiology, and both industries are almost exclusively based on microalgae. In addition, algae produce phytosterols that reduce serum cholesterol...
December 26, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29249532/omega-3-pufa-modulate-lipogenesis-er-stress-and-mitochondrial-dysfunction-markers-in-nash-proteomic-and-lipidomic-insight
#12
Lívia Samara Dos Reis Rodrigues Okada, Claudia P Oliveira, José Tadeu Stefano, Monize Aydar Nogueira, Ismael Dale Cotrim Guerreiro da Silva, Fernanda Bertucce Cordeiro, Venâncio Avancini Ferreira Alves, Raquel Susana Torrinhas, Flair José Carrilho, Puneet Puri, Dan L Waitzberg
BACKGROUND & AIMS: Currently there is no FDA-approved therapy for nonalcoholic steatohepatitis (NASH). Increased n-6/n-3 polyunsaturated fatty acids (PUFA) ratio can induce endoplasmic reticulum (ER) stress and mitochondrial dysfunction that characterize NASH. Our recent study with n-3 PUFA showed improvement in individual histologic parameters like steatosis, ballooning and lobular inflammation. We hypothesized that n-3 PUFA therapy mediated improvement in histologic parameters is modulated by lipidomic and proteomic changes...
September 7, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29236708/genome-wide-association-meta-analysis-of-fish-and-epa-dha-consumption-in-17-us-and-european-cohorts
#13
Dariush Mozaffarian, Hassan S Dashti, Mary K Wojczynski, Audrey Y Chu, Jennifer A Nettleton, Satu Männistö, Kati Kristiansson, Mägi Reedik, Jari Lahti, Denise K Houston, Marilyn C Cornelis, Frank J A van Rooij, Maria Dimitriou, Stavroula Kanoni, Vera Mikkilä, Lyn M Steffen, Marcia C de Oliveira Otto, Lu Qi, Bruce Psaty, Luc Djousse, Jerome I Rotter, Kennet Harald, Markus Perola, Harri Rissanen, Antti Jula, Fischer Krista, Evelin Mihailov, Mary F Feitosa, Julius S Ngwa, Luting Xue, Paul F Jacques, Mia-Maria Perälä, Aarno Palotie, Yongmei Liu, Nike A Nalls, Luigi Ferrucci, Dena Hernandez, Ani Manichaikul, Michael Y Tsai, Jessica C Kiefte-de Jong, Albert Hofman, André G Uitterlinden, Loukianos Rallidis, Paul M Ridker, Lynda M Rose, Julie E Buring, Terho Lehtimäki, Mika Kähönen, Jorma Viikari, Rozenn Lemaitre, Veikko Salomaa, Paul Knekt, Andres Metspalu, Ingrid B Borecki, L Adrienne Cupples, Johan G Eriksson, Stephen B Kritchevsky, Stefania Bandinelli, David Siscovick, Oscar H Franco, Panos Deloukas, George Dedoussis, Daniel I Chasman, Olli Raitakari, Toshiko Tanaka
BACKGROUND: Regular fish and omega-3 consumption may have several health benefits and are recommended by major dietary guidelines. Yet, their intakes remain remarkably variable both within and across populations, which could partly owe to genetic influences. OBJECTIVE: To identify common genetic variants that influence fish and dietary eicosapentaenoic acid plus docosahexaenoic acid (EPA+DHA) consumption. DESIGN: We conducted genome-wide association (GWA) meta-analysis of fish (n = 86,467) and EPA+DHA (n = 62,265) consumption in 17 cohorts of European descent from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium Nutrition Working Group...
2017: PloS One
https://www.readbyqxmd.com/read/29181705/coenzyme-q10-loaded-fish-oil-based-bigel-system-probing-the-delivery-across-porcine-skin-and-possible-interaction-with-fish-oil-fatty-acids
#14
Mohd Hanif Zulfakar, Lee Mei Chan, Khurram Rehman, Lam Kok Wai, Charles M Heard
Coenzyme Q10 (CoQ10) is a vitamin-like oil-soluble molecule that has anti-oxidant and anti-ageing effects. To determine the most optimal CoQ10 delivery vehicle, CoQ10 was solubilised in both water and fish oil, and formulated into hydrogel, oleogel and bigel. Permeability of CoQ10 from each formulation across porcine ear skin was then evaluated. Furthermore, the effects of the omega-3 fatty eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids from fish oil on skin permeation were investigated by means of nuclear magnetic resonance (NMR) and computerised molecular modelling docking experiments...
November 27, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29175671/dietary-omega-3-and-omega-6-polyunsaturated-fatty-acids-modulate-hepatic-pathology
#15
Saraswoti Khadge, John Graham Sharp, Geoffrey M Thiele, Timothy R McGuire, Lynell W Klassen, Michael J Duryee, Holly C Britton, Alicia J Dafferner, Jordan Beck, Paul N Black, Concetta C DiRusso, James Talmadge
Recent evidence has suggested that dietary polyunsaturated fatty acids (PUFAs) modulate inflammation; however, few studies have focused on the pathobiology of PUFA using isocaloric and isolipidic diets and it is unclear if the associated pathologies are due to dietary PUFA composition, lipid metabolism or obesity, as most studies compare diets fed ad libitum. Our studies used isocaloric and isolipidic liquid diets (35% of calories from fat), with differing compositions of omega (ω)-6 or long chain (Lc) ω-3 PUFA that were pair-fed and assessed hepatic pathology, inflammation and lipid metabolism...
October 4, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29173690/omega-3-fatty-acids-inflammatory-status-and-biochemical-markers-of-patients-with-systemic-lupus-erythematosus-a-pilot-study
#16
Mariane Curado Borges, Fabiana de Miranda Moura Dos Santos, Rosa Weiss Telles, Marcus Vinícius Melo de Andrade, Maria Isabel Toulson Davisson Correia, Cristina Costa Duarte Lanna
BACKGROUND: Studies have shown that omega-3 fatty acids reduce the concentrations of eicosanoids, cytokines, chemokines, C-reactive protein (CRP) and other inflammatory mediators. OBJECTIVE: To investigate the effects of omega-3 fatty acids on circulating levels of inflammatory mediators and biochemical markers in women with systemic lupus erythematosus (SLE). METHODS: Experimental clinical study (clinical trial: NCT02524795); 49 women with SLE (ACR1982/1997) were randomized: 22 to the omega-3 group (daily intake of 1080mg EPA+200mg DHA, for 12 weeks) and 27 to the control group...
November 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/29171642/dietary-supplements-for-cognitive-impairment
#17
Javier Olivera-Pueyo, Carmelo Pelegrín-Valero
Alzheimer disease and the other neurodegenerative dementias as yet have no curative treatment. For this reason, the prevention of these conditions and non-pharmacological treatments are important fields of research at present. The Mediterranean diet (rich in fruits, vegetables, legumes, and olive oil, with regular fish consumption and low consumption of dairy products and meats) has been shown to reduce the incidence of mild cognitive impairment (MCI) and, probably, the conversion of MCI to dementia. Vitamins, especially vitamin E and the vitamins of the B group, have also been associated with the prevention of cognitive impairment due to their antioxidant effects...
September 2017: Actas Españolas de Psiquiatría
https://www.readbyqxmd.com/read/29163147/chronic-psychological-stress-was-not-ameliorated-by-omega-3-eicosapentaenoic-acid-epa
#18
Joanne Bradbury, Stephen P Myers, Barbara Meyer, Lyndon Brooks, Jonathan Peake, Andrew J Sinclair, Con Stough
Background: Chronic psychological stress and mental health disorders are endemic in Western culture where population dietary insufficiencies of omega-3 fatty acids (n-3FA) from seafood have been observed. Objective: This study was designed to test for a causal relationship between one of the most active components of fish oil, eicosapentaenoic acid (EPA), and chronic psychological stress. Method: A randomized double-blind, placebo-controlled clinical trial with parallel-assignment to two groups was designed (Trial Id: ACTRN12610000404022)...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29156152/limited-effect-of-omega-3-fatty-acids-on-the-quality-of-life-in-survivors-of-traumatic-injury-a-randomized-placebo-controlled-trial
#19
Hiroko Noguchi, Daisuke Nishi, Kenta Matsumura, Kei Hamazaki, Tomohito Hamazaki, Yutaka J Matsuoka
Empirical evidence is divided on whether n-3 polyunsaturated fatty acid levels are associated with quality of life (QOL). This study investigated the effects of docosahexaenoic acid (DHA) supplementation on QOL in survivors of traumatic injury. In this secondary analysis of a double-blind, randomized controlled trial, we recruited 110 trauma patients (82% men; mean age, 39.6 years) in an intensive care unit. Fifty-three received DHA-rich supplements and 57 received placebo for 12 weeks. We used the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36) to assess QOL at the end of intervention...
December 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29137111/effect-of-omega-3-fatty-acid-supplementation-on-plasma-fibroblast-growth-factor-23-levels-in-post-myocardial-infarction-patients-with-chronic-kidney-disease-the-alpha-omega-trial
#20
Martin H de Borst, Leandro C Baia, Ellen K Hoogeveen, Erik J Giltay, Gerjan Navis, Stephan J L Bakker, Johanna M Geleijnse, Daan Kromhout, Sabita S Soedamah-Muthu
Fibroblast growth factor 23 (FGF23) is an independent risk factor for cardiovascular mortality in chronic kidney disease. Omega-3 (n-3) fatty acid consumption has been inversely associated with FGF23 levels and with cardiovascular risk. We examined the effect of marine n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and plant-derived alpha-linolenic acid (ALA) on plasma FGF23 levels in post-myocardial infarction patients with chronic kidney disease. In the randomized double-blind Alpha Omega Trial, 4837 patients with a history of myocardial infarction aged 60-80 years (81% men) were randomized to one of four trial margarines supplemented with a targeted additional intake of 400 mg/day EPA and DHA, 2 g/day ALA, EPA-DHA plus ALA, or placebo for 41 months...
November 11, 2017: Nutrients
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