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https://www.readbyqxmd.com/read/29669276/tmem150c-tentonin3-is-a-regulator-of-mechano-gated-ion-channels
#1
Evan O Anderson, Eve R Schneider, Jon D Matson, Elena O Gracheva, Sviatoslav N Bagriantsev
Neuronal mechano-sensitivity relies on mechano-gated ion channels, but pathways regulating their activity remain poorly understood. TMEM150C was proposed to mediate mechano-activated current in proprioceptive neurons. Here, we studied functional interaction of TMEM150C with mechano-gated ion channels from different classes (Piezo2, Piezo1, and the potassium channel TREK-1) using two independent methods of mechanical stimulation. We found that TMEM150C significantly prolongs the duration of the mechano-current produced by all three channels, decreases apparent activation threshold in Piezo2, and induces persistent current in Piezo1...
April 17, 2018: Cell Reports
https://www.readbyqxmd.com/read/29626181/disability-in-adults-with-arthrogryposis-is-severe-partly-invisible-and-varies-by-genotype
#2
Shenhao Dai, Klaus Dieterich, Marie Jaeger, Bernard Wuyam, Pierre-Simon Jouk, Dominic Pérennou
OBJECTIVE: To understand the disability of adults with arthrogryposis multiplex congenita (AMC), a rare disease spectrum characterized by at least 2 joint contractures at birth in different body areas. METHODS: This is a retrospective analysis of data for unselected persons with AMC referred to the French center for adults with AMC from 2010 to 2016. All underwent a pluriprofessional systematic and comprehensive investigation of deficits, activity limitation, and participation restriction according to the International Classification of Functioning, Disability and Health and genetic analysis when indicated...
April 6, 2018: Neurology
https://www.readbyqxmd.com/read/29521261/myotubularin-related-protein-2-and-its-phospholipid-substrate-pip-2-control-piezo2-mediated-mechanotransduction-in-peripheral-sensory-neurons
#3
Pratibha Narayanan, Meike Hütte, Galina Kudryasheva, Francisco J Taberner, Stefan G Lechner, Florian Rehfeldt, David Gomez-Varela, Manuela Schmidt
Piezo2 ion channels are critical determinants of the sense of light touch in vertebrates. Yet, their regulation is only incompletely understood. We recently identified myotubularin related protein-2 (Mtmr2), a phosphoinositide (PI) phosphatase, in the native Piezo2 interactome of murine dorsal root ganglia (DRG). Here, we demonstrate that Mtmr2 attenuates Piezo2-mediated rapidly adapting mechanically activated (RA-MA) currents. Interestingly, heterologous Piezo1 and other known MA current subtypes in DRG appeared largely unaffected by Mtmr2...
March 9, 2018: ELife
https://www.readbyqxmd.com/read/29471041/mechanically-activated-ion-channels
#4
Boris Martinac, Kate Poole
The ability of cells to sense and respond to their physical environment is fundamental to a broad spectrum of biological processes. Cells express an array of force sensors that can transduce mechanical inputs into biochemical signals, including the mechanically activated ion channels PIEZO1, PIEZO2 and TRPV4. The identification and characterisation of mechanically activated ion channels has proven challenging, as has identifying their mode of activation and regulation in vivo. However, the diverse channelopathies associated with the known channels highlights their physiological importance...
February 20, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29432180/piezo2-channel-regulates-rhoa-and-actin-cytoskeleton-to-promote-cell-mechanobiological-responses
#5
Carlos Pardo-Pastor, Fanny Rubio-Moscardo, Marina Vogel-González, Selma A Serra, Alexandros Afthinos, Sanela Mrkonjic, Olivier Destaing, Juan F Abenza, José M Fernández-Fernández, Xavier Trepat, Corinne Albiges-Rizo, Konstantinos Konstantopoulos, Miguel A Valverde
Actin polymerization and assembly into stress fibers (SFs) is central to many cellular processes. However, how SFs form in response to the mechanical interaction of cells with their environment is not fully understood. Here we have identified Piezo2 mechanosensitive cationic channel as a transducer of environmental physical cues into mechanobiological responses. Piezo2 is needed by brain metastatic cells from breast cancer (MDA-MB-231-BrM2) to probe their physical environment as they anchor and pull on their surroundings or when confronted with confined migration through narrow pores...
February 5, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29374927/-advances-in-the-research-of-function-of-merkel-cells-in-tactile-formation-of-skin
#6
X You, Z R Wei
Skin is the largest sense organ of human, with many mechanoreceptor cells under epidermis or dermis of skin and Merkel cell is one of them. It has been confirmed that Merkel cells play an important role in the process of mechanical transmission of mammalian soft tactile stimulation. Researches showed that Merkel cells had close relation to tactile formation and functioned by Merkel cell-neurite complexes and ion channels Piezo2. This article reviews Merkel cells and the function, problem and prospect of Merkel cells in tactile formation...
January 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29324706/endothelial-ca-2-signaling-and-the-resistance-to-anticancer-treatments-partners-in-crime
#7
REVIEW
Francesco Moccia
Intracellular Ca2+ signaling drives angiogenesis and vasculogenesis by stimulating proliferation, migration, and tube formation in both vascular endothelial cells and endothelial colony forming cells (ECFCs), which represent the only endothelial precursor truly belonging to the endothelial phenotype. In addition, local Ca2+ signals at the endoplasmic reticulum (ER)-mitochondria interface regulate endothelial cell fate by stimulating survival or apoptosis depending on the extent of the mitochondrial Ca2+ increase...
January 11, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29261642/structure-of-the-mechanically-activated-ion-channel-piezo1
#8
Kei Saotome, Swetha E Murthy, Jennifer M Kefauver, Tess Whitwam, Ardem Patapoutian, Andrew B Ward
Piezo1 and Piezo2 are mechanically activated ion channels that mediate touch perception, proprioception and vascular development. Piezo proteins are distinct from other ion channels and their structure remains poorly defined, which impedes detailed study of their gating and ion permeation properties. Here we report a high-resolution cryo-electron microscopy structure of the mouse Piezo1 trimer. The detergent-solubilized complex adopts a three-bladed propeller shape with a curved transmembrane region containing at least 26 transmembrane helices per protomer...
February 22, 2018: Nature
https://www.readbyqxmd.com/read/29241539/functional-and-molecular-characterization-of-mechanoinsensitive-silent-nociceptors
#9
Vincenzo Prato, Francisco J Taberner, James R F Hockley, Gerard Callejo, Alice Arcourt, Bassim Tazir, Leonie Hammer, Paulina Schad, Paul A Heppenstall, Ewan S Smith, Stefan G Lechner
Mechanical and thermal hyperalgesia (pain hypersensitivity) are cardinal signs of inflammation. Although the mechanism underlying thermal hyperalgesia is well understood, the cellular and molecular basis of mechanical hyperalgesia is poorly described. Here, we have identified a subset of peptidergic C-fiber nociceptors that are insensitive to noxious mechanical stimuli under normal conditions but become sensitized to such stimuli when exposed to the inflammatory mediator nerve growth factor (NGF). Strikingly, NGF did not affect mechanosensitivity of other nociceptors...
December 12, 2017: Cell Reports
https://www.readbyqxmd.com/read/29228535/the-role-of-piezo2-in-human-mechanosensation
#10
Nima Rezaei, Amene Saghazadeh
No abstract text is available yet for this article.
October 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29212024/cell-type-specific-splicing-of-piezo2-regulates-mechanotransduction
#11
Marcin Szczot, Leah A Pogorzala, Hans Jürgen Solinski, Lynn Young, Philina Yee, Claire E Le Pichon, Alexander T Chesler, Mark A Hoon
Piezo2 is a mechanically activated ion channel required for touch discrimination, vibration detection, and proprioception. Here, we discovered that Piezo2 is extensively spliced, producing different Piezo2 isoforms with distinct properties. Sensory neurons from both mice and humans express a large repertoire of Piezo2 variants, whereas non-neuronal tissues express predominantly a single isoform. Notably, even within sensory ganglia, we demonstrate the splicing of Piezo2 to be cell type specific. Biophysical characterization revealed substantial differences in ion permeability, sensitivity to calcium modulation, and inactivation kinetics among Piezo2 splice variants...
December 5, 2017: Cell Reports
https://www.readbyqxmd.com/read/29171028/the-mechanosensitive-piezo1-channel-structural-features-and-molecular-bases-underlying-its-ion-permeation-and-mechanotransduction
#12
Yubo Wang, Bailong Xiao
The evolutionarily conserved Piezo family of proteins, including Piezo1 and Piezo2, encodes the long-sought-after mammalian mechanosensitive cation channels that play critical roles in various mechanotransduction processes such as touch, pain, proprioception, vascular development and blood pressure regulation. Mammalian Piezo proteins contain over 2500 amino acids with numerous predicted transmembrane segments, and do not bear sequence homology with any known class of ion channels. Thus, it is imperative, but challenging, to understand how they serve as effective mechanotransducers for converting mechanical force into electrochemical signals...
November 24, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29162691/dabbling-with-piezo2-for-mechanosensation
#13
Ruhma Syeda
No abstract text is available yet for this article.
December 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29109250/molecular-basis-of-tactile-specialization-in-the-duck-bill
#14
Eve R Schneider, Evan O Anderson, Marco Mastrotto, Jon D Matson, Vincent P Schulz, Patrick G Gallagher, Robert H LaMotte, Elena O Gracheva, Sviatoslav N Bagriantsev
Tactile-foraging ducks are specialist birds known for their touch-dependent feeding behavior. They use dabbling, straining, and filtering to find edible matter in murky water, relying on the sense of touch in their bill. Here, we present the molecular characterization of embryonic duck bill, which we show contains a high density of mechanosensory corpuscles innervated by functional rapidly adapting trigeminal afferents. In contrast to chicken, a visually foraging bird, the majority of duck trigeminal neurons are mechanoreceptors that express the Piezo2 ion channel and produce slowly inactivating mechano-current before hatching...
December 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29030909/global-gene-expression-profiles-of-hematopoietic-stem-and-progenitor-cells-from-patients-with-chronic-myeloid-leukemia-the-effect-of-in-vitro-culture-with-or-without-imatinib
#15
Sócrates Avilés-Vázquez, Antonieta Chávez-González, Alfredo Hidalgo-Miranda, Dafne Moreno-Lorenzana, Lourdes Arriaga-Pizano, Miguel Á Sandoval-Esquivel, Manuel Ayala-Sánchez, Rafael Aguilar, Luis Alfaro-Ruiz, Hector Mayani
In this study, we determined the gene expression profiles of bone marrow-derived cell fractions, obtained from normal subjects and Chronic Myeloid Leukemia (CML) patients, that were highly enriched for hematopoietic stem (HSCs) and progenitor (HPCs) cells. Our results indicate that the profiles of CML HSCs and HPCs were closer to that of normal progenitors, whereas normal HSCs showed the most different expression profile of all. We found that the expression profiles of HSCs and HPCs from CML marrow were closer to each other than those of HSCs and HPCs from normal marrow...
December 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28983916/piezo2-as-the-anomalous-mechanotransducer-channel-in-auditory-hair-cells
#16
Maryline Beurg, Robert Fettiplace
Throughout postnatal maturation of the mouse inner ear, cochlear hair cells display at least two types of mechanically gated ion channel: normal mechanotransducer (MT) channels at the tips of the stereocilia, activated by tension in interciliary tip links, and anomalous mechanosensitive (MS) channels on the top surface of the cells. The anomalous MS channels are responsible for the reverse-polarity current that appears in mutants in which normal transduction is lost. They are also seen in wild-type hair cells around birth, appearing 2 days earlier than normal MT channels, and being down-regulated with the emergence of the normal channels...
December 1, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28957441/diversity-amongst-trigeminal-neurons-revealed-by-high-throughput-single-cell-sequencing
#17
Minh Q Nguyen, Youmei Wu, Lauren S Bonilla, Lars J von Buchholtz, Nicholas J P Ryba
The trigeminal ganglion contains somatosensory neurons that detect a range of thermal, mechanical and chemical cues and innervate unique sensory compartments in the head and neck including the eyes, nose, mouth, meninges and vibrissae. We used single-cell sequencing and in situ hybridization to examine the cellular diversity of the trigeminal ganglion in mice, defining thirteen clusters of neurons. We show that clusters are well conserved in dorsal root ganglia suggesting they represent distinct functional classes of somatosensory neurons and not specialization associated with their sensory targets...
2017: PloS One
https://www.readbyqxmd.com/read/28955292/molecular-mechanisms-that-contribute-to-bone-marrow-pain
#18
REVIEW
Jason J Ivanusic
Pain associated a bony pathology puts a significant burden on individuals, society, and the health-care systems worldwide. Pathology that involves the bone marrow activates sensory nerve terminal endings of peripheral bone marrow nociceptors, and is the likely trigger for pain. This review presents our current understanding of how bone marrow nociceptors are influenced by noxious stimuli presented in pathology associated with bone marrow. A number of ion channels and receptors are emerging as important modulators of the activity of peripheral bone marrow nociceptors...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28905996/merkel-cells-and-meissner-s-corpuscles-in-human-digital-skin-display-piezo2-immunoreactivity
#19
Y García-Mesa, J García-Piqueras, B García, J Feito, R Cabo, J Cobo, J A Vega, O García-Suárez
The transformation of mechanical energy into electrical signals is the first step in mechanotransduction in the peripheral sensory nervous system and relies on the presence of mechanically gated ion channels within specialized sensory organs called mechanoreceptors. Piezo2 is a vertebrate stretch-gated ion channel necessary for mechanosensitive channels in mammalian cells. Functionally, it is related to light touch, which has been detected in murine cutaneous Merkel cell-neurite complexes, Meissner-like corpuscles and lanceolate nerve endings...
December 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28835637/cutaneous-pigmentation-modulates-skin-sensitivity-via-tyrosinase-dependent-dopaminergic-signalling
#20
Kentaro Ono, Chi T Viet, Yi Ye, Dongmin Dang, Suzuro Hitomi, Takashi Toyono, Kiyotoshi Inenaga, John C Dolan, Brian L Schmidt
We propose a new mechanism of sensory modulation through cutaneous dopaminergic signalling. We hypothesize that dopaminergic signalling contributes to differential cutaneous sensitivity in darker versus lighter pigmented humans and mouse strains. We show that thermal and mechanical cutaneous sensitivity is pigmentation dependent. Meta-analyses in humans and mice, along with our own mouse behavioural studies, reveal higher thermal sensitivity in pigmented skin relative to less-pigmented or albino skin. We show that dopamine from melanocytes activates the D1 -like dopamine receptor on primary sensory neurons...
August 23, 2017: Scientific Reports
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