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Bastian Bonhoeffer, Arno Kwade, Michael Juhnke
Flexible manufacturing processes with continuously adjustable dose strengths are considered particularly innovative and interesting for applications in personalized medicine, continuous manufacturing or early drug development. A piezo-actuated micro-valve has been investigated for the dispensing and depositioning of drug nanosuspensions onto substrates to facilitate the manufacturing of solid oral dosage forms. The investigated micro-valve has been characterized regarding dispensing behavior, mass flow, accuracy and robustness...
January 3, 2017: Journal of Pharmaceutical Sciences
Oleh Krupych, Oksana Mys, Taras Kryvyy, Volodymyr Adamiv, Yaroslav Burak, Rostyslav Vlokh
We report the results of comprehensive studies of the piezo-optic and elasto-optic effects in lithium tetraborate crystals, Li<sub>2</sub>B<sub>4</sub>O<sub>7</sub>. The full matrices of piezo-optic and elasto-optic coefficients are obtained using a recently developed method based on four-point bending. On this basis, we have estimated the acousto-optic figure of merit for Li<sub>2</sub>B<sub>4</sub>O<sub>7</sub>.
December 20, 2016: Applied Optics
Sulphi A Basheer, R Jay Govind, Augustine Daniel, George Sam, V J Adarsh, Akshatha Rao
INTRODUCTION: Bone removal is necessary for extracting the third molars that are erupted, partially erupted, and/or impacted in bone. Hence, it is necessary to choose a surgical method or instruments that conform to anatomic landmarks and are based on physiological principles. Many authors have reported injuries to the adjacent tooth, especially the distal part of periodontium after removal of second molar. Hence, the present study was undertaken to assess and compare the surgical and postsurgi-cal outcomes of third molar removal using piezoelectric surgery and rotary bur...
January 1, 2017: Journal of Contemporary Dental Practice
Taka-Aki Kuribayashi, Sotaro Fujii, Misa Masanari, Masaru Yamanaka, Satoshi Wakai, Yoshihiro Sambongi
Shewanella species are widely distributed in sea, brackish, and fresh water areas, growing psychrophilically or mesophilically, and piezophilically or piezo-sensitively. Here, membrane-bound 5'-nucleotidases (NTases) from deep-sea Shewanella violacea and brackish water Shewanella amazonensis were examined from the aspect of NaCl tolerance to gain an insight into protein stability against salt. Both NTases were single polypeptides with molecular masses of ~59 kDa, as determined on mass spectroscopy. They similarly required 10 mM MgCl2 for their activities, and they exhibited the same pH dependency and substrate specificity for 5'-nucleotides...
January 3, 2017: Extremophiles: Life Under Extreme Conditions
A Soliman, B Chugh, B Keller, A Sahgal, W Song
PURPOSE: Recent advances in MRI-guided radiotherapy has inspired the development of MRI-compatible motion devices that simulate patient periodic motion in the scanner, particularly respiratory motion. Most commercial devices rely on non MR-safe ferromagnetic stepper motors which are not practical for regular QA testing. This work evaluates the motion performance of a new fully MRI compatible respiratory motion device at 3T. METHODS: The QUASAR™ MRI-compatible respiratory motion phantom has been recently developed by Modus QA Inc...
June 2016: Medical Physics
Tao Bai, Ying Li, Jing Xia, Yudong Jiang, Lei Zhang, Huan Wang, Wei Qian, Jun Song, Xiaohua Hou
Background/Aim: Currently, there exists no biomarker for visceral hypersensitivity in Irritable Bowel Syndrome (IBS). Piezo proteins have been proven to play an important role in the mechanical stimulation to induce visceral pain in other tissues and may also be a biomarker candidate. The aim of this study was to test the expressions of Piezo1 and Piezo2 proteins in the intestinal epithelial cells from different intestinal segments and to explore the correlation between Piezo proteins expression and visceral pain threshold...
January 2, 2017: Journal of Neurogastroenterology and Motility
N C Pisenti, A Restelli, B J Reschovsky, D S Barker, G K Campbell
We present an ultra-low noise, high-voltage driver suited for use with piezoelectric actuators and other low-current applications. The architecture uses a flyback switching regulator to generate up to 250 V in our current design, with an output of 1 kV or more possible with small modifications. A high slew-rate op-amp suppresses the residual switching noise, yielding a total root-mean-square noise of ≈100 μV (1 Hz-100 kHz). A low-voltage (±10 V), high bandwidth signal can be summed with unity gain directly onto the output, making the driver well-suited for closed-loop feedback applications...
December 2016: Review of Scientific Instruments
Johannes Möller, Joachim Léonardon, Jacques Gorini, Rajeev Dattani, Theyencheri Narayanan
We present a new experimental setup for time-resolved solution small-angle X-ray scattering (SAXS) studies of kinetic processes induced by sub-ms hydrostatic pressure jumps. It is based on a high-force piezo-stack actuator, with which the volume of the sample can be dynamically compressed. The presented setup has been designed and optimized for SAXS experiments with absolute pressures of up to 1000 bars, using transparent diamond windows and an easy-to-change sample capillary. The pressure in the cell can be changed in less than 1 ms, which is about an order of magnitude faster jump than previously obtained by dynamic pressure setups for SAXS...
December 2016: Review of Scientific Instruments
Laura Costarelli, Robertina Giacconi, Marco Malavolta, Andrea Basso, Francesco Piacenza, Mauro Provinciali, Marcello G Maggio, Andrea Corsonello, Fabrizia Lattanzio
Recent evidence suggests that high dose and/or long term use of proton pump inhibitors (PPIs) may increase the risk of adverse cardiovascular events in older patients, but mechanisms underlying these detrimental effects are not known. Taking into account that the senescent endothelial cells have been implicated in the genesis or promotion of age-related cardiovascular disease, we hypothesized an active role of PPIs in senescent cells. The aim of this study is to investigate the changes in gene expression occurring in senescent and non-senescent human coronary artery endothelial cells (HCAECs) following Omeprazole (OPZ) or Lansoprazole (LPZ) treatment...
December 30, 2016: Biogerontology
Xin Huang, Chunyan Jiang, Chunhua Du, Liang Jing, Mengmeng Liu, Weiguo Hu, Zhong Lin Wang
With a promising prospect of light-emitting diodes as an attractive alternative to conventional light sources, remaining challenges still cannot be addressed owing to their limited efficiency. Among the continued scientific efforts, significant improvement on the emission efficiency has been achieved via either piezo-phototronic effect-based strain modulation or resonant excitation of plasmons in metallic nanostructures. Here, we present the investigation on the coupling process between piezo-phototronic effect and localized surface plasmonic resonance for enhancing the photoluminescence of InGaN/GaN quantum wells coated with Ag nanoparticles...
December 27, 2016: ACS Nano
Hidenori Endo, Toshiki Endo, Atsuhiro Nakagawa, Miki Fujimura, Teiji Tominaga
In clipping surgery for aneurysmal subarachnoid hemorrhage (aSAH), critical steps include clot removal and dissection of aneurysms without premature rupture or brain injuries. To pursue this goal, a piezo actuator-driven pulsed water jet (ADPJ) system was introduced in this study. This study included 42 patients, who suffered aSAH and underwent clipping surgery. Eleven patients underwent surgery with the assistance of the ADPJ system (ADPJ group). In the other 31 patients, surgery was performed without the ADPJ system (Control group)...
December 22, 2016: Neurosurgical Review
Young Kwon Kim, Ju An Park, Woong Hee Yoon, Joonwon Kim, Sungjune Jung
We present drop-on-demand inkjet-based mammalian cell printing with a 30-μm nozzle diameter for cell-level accuracy. High-speed imaging techniques have been used to analyze the go-and-stop movement of cells inside the nozzle under a pulsed pressure generated by a piezo-actuator and the jet formation after ejection. Patterning of an array of 20 × 20 dots on a glass substrate reveals that each printed drop contains 1.30 cells on average at the cell concentration of 5.0 × 10(6) cells ml(-1) for the very small nozzle, whereas larger nozzles with the diameter of 50 and 80 μm deliver 2...
November 2016: Biomicrofluidics
Goknur Haliloglu, Kerstin Becker, Cagri Temucin, Beril Talim, Nalan Küçükşahin, Matthias Pergande, Susanne Motameny, Peter Nürnberg, Ustun Aydingoz, Haluk Topaloglu, Sebahattin Cirak
The genetic work-up of arthrogryposis is challenging due to the diverse clinical and molecular etiologies. We report a-18(3/12)-year-old boy, from a 2nd degree consanguineous family, who presented at 3(6/12) years with hypotonia, distal laxity, contractures, feeding difficulties at birth. He required surgery for progressive scoliosis at 16 years of age, and walked independently since then with an unstable gait and coordination defects. His latest examination at 18 years of age revealed a proprioceptive defect and loss-of-joint position sense in the upper limbs...
December 15, 2016: Journal of Human Genetics
Sanghyun Hong, Troy Lundstrom, Ranajay Ghosh, Hamed Abdi, Ji Hao, Sun Kyoung Jeoung, Paul Su, Jonghwan Suhr, Ashkan Vaziri, Nader Jalili, Yung Joon Jung
We have created a multifunctional dry adhesive film with transferred vertically aligned carbon nanotubes (VA-CNTs). This unique VA-CNT film was fabricated by a multistep transfer process, converting the flat and uniform bottom of VA-CNTs grown on atomically flat silicon wafer substrates into the top surface of an adhesive layer. Unlike as-grown VA-CNTs, which have a nonuniform surface, randomly entangled CNT arrays, and a weak interface between the CNTs and substrates, this transferred VA-CNT film shows an extremely high coefficient of static friction (COF) of up to 60 and a shear adhesion force 30 times higher (12 N/cm(2)) than that of the as-grown VA-CNTs under a very small preloading of 0...
December 14, 2016: ACS Applied Materials & Interfaces
Yin-Yan Lin, Hau-Tieng Wu, Chi-An Hsu, Po-Chiun Huang, Yuan-Hao Huang, Yu-Lun Lo
Physiologically, the thoracic (THO) and abdominal (ABD) movement signals, captured using wearable piezo-electric bands, provide information about various types of apnea, including central sleep apnea (CSA) and obstructive sleep apnea (OSA). However, the use of piezo-electric wearables in detecting sleep apnea events has been seldom explored in the literature. This study explored the possibility of identifying sleep apnea events, including OSA and CSA, by solely analyzing one or both the THO and ABD signals...
December 7, 2016: IEEE Journal of Biomedical and Health Informatics
David Goldovsky, Valery Jouravsky, Avi Pe'er
We present an approach to locking of optical cavities with piezoelectric actuated mirrors based on a simple and effective mechanical decoupling of the mirror and actuator from the surrounding mount. Using simple elastic materials (e.g. rubber or soft silicone gel pads) as mechanical dampers between the piezo-mirror compound and the surrounding mount, a firm and stable mounting of a relatively large mirror (8mm diameter) can be maintained that is isolated from external mechanical resonances, and is limited only by the internal piezo-mirror resonance of > 330 KHz...
December 12, 2016: Optics Express
Christiane Wetzel, Simone Pifferi, Cristina Picci, Caglar Gök, Diana Hoffmann, Kiran K Bali, André Lampe, Liudmila Lapatsina, Raluca Fleischer, Ewan St John Smith, Valérie Bégay, Mirko Moroni, Luc Estebanez, Johannes Kühnemund, Jan Walcher, Edgar Specker, Martin Neuenschwander, Jens Peter von Kries, Volker Haucke, Rohini Kuner, James F A Poulet, Jan Schmoranzer, Kate Poole, Gary R Lewin
The skin is equipped with specialized mechanoreceptors that allow the perception of the slightest brush. Indeed, some mechanoreceptors can detect even nanometer-scale movements. Movement is transformed into electrical signals via the gating of mechanically activated ion channels at sensory endings in the skin. The sensitivity of Piezo mechanically gated ion channels is controlled by stomatin-like protein-3 (STOML3), which is required for normal mechanoreceptor function. Here we identify small-molecule inhibitors of STOML3 oligomerization that reversibly reduce the sensitivity of mechanically gated currents in sensory neurons and silence mechanoreceptors in vivo...
December 12, 2016: Nature Neuroscience
Guoquan Suo, Yanhao Yu, Zhiyi Zhang, Shifa Wang, Ping Zhao, Jianye Li, Xudong Wang
Piezoelectric and triboelectric nanogenerators have been developed as rising energy-harvesting devices in the past few years to effectively convert mechanical energy into electricity. Here, a novel hybrid piezo/triboelectric nanogenerator based on BaTiO3 NP/PDMS composite film was developed in a simple and low-cost way. The effects of the BTO content and polarization degree on the output performance were systematically studied. The device with 20 wt % BTO in PDMS and a 100-μm-thick film showed the highest output power...
December 21, 2016: ACS Applied Materials & Interfaces
Herman Vercruysse, Ramon Sieira-Gil, Alfons Navarro, Eloy Garcia-Diez
BACKGROUND: Midface advancement is a keystone intervention in the treatment plan of syndromic hypoplasia of the midface. Although earlier authors had been using a combination of smaller incisions to acquire enough access to perform the different osteotomies, Tessier popularized the bicoronal incision. This approach can be time-consuming however and leaves an ear-to-ear scar. The authors describe an endoscopically assisted piezo-electric Le Fort III osteotomy performed through minimal invasive access...
December 5, 2016: Journal of Craniofacial Surgery
Weilin Chen, Xianmin Zhang, Sergej Fatikow
For the piezo-driven microgripper, one issue is to enlarge the grasping stroke and realize parallel grasping movement in the compact design. Piezoelectric stack actuator (PSA) and piezoelectric cantilever actuator (PCA) are two kinds of typical piezoelectric actuators. In this study, a novel microgripper hybrid driven by a PSA and two PCAs is proposed, which can be a better solution for the issue, compared with the previous microgripper using PSA-driven multi-stages displacement amplification mechanism (DAM) or using longer and narrower PCAs...
November 2016: Review of Scientific Instruments
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