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Federico Gelpi, Daniele De Santis, Simone Marconcini, Francesco Briguglio, Marco Finotti
This clinical report illustrates a multidisciplinary approach for the rehabilitation of a young adult patient affected by a bilateral edentulous space and an anterior deep bite. The patient required orthodontics and surgical corticotomy and implantology (both performed with a piezo device). A multidisciplinary planning approach, including orthodontics, oral and periodontic surgery, and restorative dentistry, has an important role in the final outcome of treatment. In fact a dental class I occlusion has been established only on the right side...
December 2015: Int J Implant Dent
Jason Wu, Amanda H Lewis, Jörg Grandl
In 2010, two proteins, Piezo1 and Piezo2, were identified as the long-sought molecular carriers of an excitatory mechanically activated current found in many cells. This discovery has opened the floodgates for studying a vast number of mechanotransduction processes. Over the past 6 years, groundbreaking research has identified Piezos as ion channels that sense light touch, proprioception, and vascular blood flow, ruled out roles for Piezos in several other mechanotransduction processes, and revealed the basic structural and functional properties of the channel...
October 12, 2016: Trends in Biochemical Sciences
Tsontcho Ianchulev, Arturo Chayet, Malik Kahook, Mark Packer, Louis Pasquale, Robert N Weinreb
AIM: Eyedroppers deliver medication volumes exceeding conjunctival absorptive capacity, causing spillage and risking ocular/systemic complications. We evaluated piezoelectric microdosing. Results/methodology: Subjects (n = 102) received precision microdroplet delivery of phenylephrine (2.5%) and tropicamide (1.0%): 1 × 1.5 μl, 1 × 6 μl or 2 × 3 μl of each (randomized 1:1:1), into one eye. Contralateral eyes received eyedropper doses of both drugs. Outcomes were pupil dilation (0-60 min) and patient satisfaction...
October 13, 2016: Therapeutic Delivery
Franz Alisch, Alexander Weichert, Karim Kalache, Viola Paradiso, Ann Carolin Longardt, Christof Dame, Katrin Hoffmann, Denise Horn
Gordon syndrome or distal arthrogryposis type 3 is a rare autosomal dominant disorder characterized by contractures of upper and lower limbs. It is distinguishable from other forms of distal arthrogryposis by cleft palate and short stature. Recently, Gordon syndrome has been associated to heterozygous mutations in the piezo-type mechanosensitive ion channel component 2 gene (PIEZO2). Different mutations of this gene also cause distal arthrogryposis type 5 and Marden-Walker syndrome. Dysfunction of this ion channel provides pleiotropic effects on joints, ocular muscles, and bone development...
October 7, 2016: American Journal of Medical Genetics. Part A
Jason Wu, Raman Goyal, Jörg Grandl
Piezos are mechanically activated ion channels that function as sensors of touch and pressure in various cell types. However, the precise mechanism and structures mediating mechanical activation and subsequent inactivation have not yet been identified. Here we use magnetic nanoparticles as localized transducers of mechanical force in combination with pressure-clamp electrophysiology to identify mechanically sensitive domains important for activation and inactivation.
October 3, 2016: Nature Communications
Donghyuk Lee, Joonhui Kim, Nam-Joon Cho, Taewook Kang, Sangken Kauh, Jungchul Lee
This paper reports a microfabrication-free approach to make hollow channel mass sensors by pulling a glass capillary and suspending it on top of a machined jig. A part of the pulled section makes simple contact with an actuation node and a quartz tuning fork (QTF) which acts as a sensing node. The two nodes define a pulled micro capillary tube resonator (PμTR) simply supported at two contacts. While a piezo actuator beneath the actuation node excites the PμTR, the QTF senses the resonance frequency of the PμTR...
October 3, 2016: Scientific Reports
Jyung Hyun Lee, Hyo Soon Park, Qun Wei, Myoung Nam Kim, Jin-Ho Cho
ABSTACT To ensure the safety and efficacy of implantable hearing aids, animal experiments are an essential developmental procedure, in particular, auditory brainstem responses (ABRs) can be used to verify the objective effectiveness of implantable hearing aids. This study measured and compared the ABRs generated when applying the same vibration stimuli to an oval window and round window. The ABRs were measured using a TDT system 3 (TDT, USA), while the vibration stimuli were applied to a round window and oval window in 4 guinea pigs using a piezo-electric transducer with a proper contact tip...
September 30, 2016: Bioengineered
Francesco Aggogeri, Alberto Borboni, Angelo Merlo, Nicola Pellegrini, Raffaele Ricatto
This paper proposes an innovative mechatronic piezo-actuated module to control vibrations in modern machine tools. Vibrations represent one of the main issues that seriously compromise the quality of the workpiece. The active vibration control (AVC) device is composed of a host part integrated with sensors and actuators synchronized by a regulator; it is able to make a self-assessment and adjust to alterations in the environment. In particular, an innovative smart actuator has been designed and developed to satisfy machining requirements during active vibration control...
2016: Sensors
Konstantinos Chatzipanagis, Christoph G Baumann, Monica Sandri, Simone Sprio, Anna Tampieri, Roland Kröger
: We report the design, fabrication and application of a novel micro-electromechanical device coupled to a confocal Raman microscope that enables in situ molecular investigations of micro-fibers under uniaxial tensile load. This device allows for the mechanical study of micro-fibers with diameters in the range between 10 and 100μm and lengths of several hundred micrometers. By exerting forces in the mN range, the device enables an important force range to be accessed between that of atomic force microscopy and macroscopic stress-strain measurement devices...
September 22, 2016: Acta Biomaterialia
Yujie Shen, Dmitri V Voronine, Alexei V Sokolov, Marlan O Scully
We demonstrate, for the first time, single-beam heterodyne FAST CARS imaging without data post-processing and with nonresonant background subtraction in a simple setup via the real-time piezo modulation of the probe delay. Our fast signal acquisition scheme does not require a spatial light modulator in the pulse shaper, and is suitable for high-resolution imaging and time-resolved dynamics. In addition, the spectral detection of the back-scattered FAST CARS signal is incorporated into the pulse shaper, allowing for a compact and more efficient design...
September 19, 2016: Optics Express
Misa Masanari, Sotaro Fujii, Kazuki Kawahara, Hiroya Oki, Hirofumi Tsujino, Takahiro Maruno, Yuji Kobayashi, Tadayasu Ohkubo, Satoshi Wakai, Yoshihiro Sambongi
Monomeric cytochrome c5 from deep-sea piezophilic Shewanella violacea (SVcytc5) was stable against heat and denaturant compared with the homologous protein from shallow-sea piezo-sensitive Shewanella livingstonensis (SLcytc5). Here, the SVcytc5 crystal structure revealed that the Lys-50 side chain on the flexible loop formed a hydrogen bond with heme whereas that of corresponding hydrophobic Leu-50 could not form such a bond in SLcytc5, which appeared to be one of possible factors responsible for the difference in stability between the two proteins...
December 2016: Bioscience, Biotechnology, and Biochemistry
Till Moritz Einger, Martin Koch, Matthias Bornitz, Thomas Zahnert
HYPOTHESIS: An implantable acousto-mechanical transducer will yield a higher output if its mass can be virtually increased through the use of a secondary actuator. BACKGROUND: Current hearing aids and implants rely on feedback compensation to prevent instability (e.g. howling), usually in the form of a digital or analogue filter. We examine the effect of mechanically stabilizing a piezo-driven mechanical amplifier inserted into the incudostapedial joint gap. The aim of this study is to determine whether this is possible and discern the advantages and disadvantages of the design...
October 2016: Otology & Neurotology
Miaoling Que, Ranran Zhou, Xiandi Wang, Zuqing Yuan, Guofeng Hu, Caofeng Pan
Wurtzite structured materials, like ZnO, GaN, CdS, and InN, simultaneously possess semiconductor and piezoelectric properties. The inner-crystal piezopotential induced by external strain can effectively tune/control the carrier generation, transport and separation/combination processes at the metal-semiconductor contact or p-n junction, which is called the piezo-phototronic effect. This effect can efficiently enhance the performance of photovoltaic devices based on piezoelectric semiconductor materials by utilizing the piezo-polarization charges at the junction induced by straining, which can modulate the energy band of the piezoelectric material and then accelerate or prevent the separation process of the photon-generated electrons and vacancies...
November 2, 2016: Journal of Physics. Condensed Matter: An Institute of Physics Journal
S Becker, U Popp, C Greiner
Tribology is the science of interacting surfaces in relative motion. Processes like the transition from static to dynamic friction are fast and complex, especially as the contacting interface is buried. A direct view at the interface, in order to gain a deeper understanding of the interaction between the materials, is therefore of great interest. The reciprocating optical in situ tribometer introduced here observes the interface of two contacting materials (one of them being optical transparent) with a high-speed camera, taking up to 230 000 frames per second...
August 2016: Review of Scientific Instruments
Mayank Baranwal, Ram S Gorugantu, Srinivasa M Salapaka
Atomic force microscopy typically relies on high-resolution high-bandwidth cantilever deflection measurements based control for imaging and estimating sample topography and properties. More precisely, in amplitude-modulation atomic force microscopy (AM-AFM), the control effort that regulates deflection amplitude is used as an estimate of sample topography; similarly, contact-mode AFM uses regulation of deflection signal to generate sample topography. In this article, a control design scheme based on an additional feedback mechanism that uses vertical z-piezo motion sensor, which augments the deflection based control scheme, is proposed and evaluated...
August 2016: Review of Scientific Instruments
Benjamin L Schwartz, Ziying Yin, Richard L Magin
Cylindrical homogenous phantoms for magnetic resonance (MR) elastography in biomedical research provide one way to validate an imaging systems performance, but the simplified geometry and boundary conditions can cloak complexity arising at tissue interfaces. In an effort to develop a more realistic gel tissue phantom for MRE, we have constructed a heterogenous gel phantom (a sphere centrally embedded in a cylinder). The actuation comes from the phantom container, with the mechanical waves propagating toward the center, focusing the energy and thus allowing for the visualization of high-frequency waves that would otherwise be damped...
September 21, 2016: Physics in Medicine and Biology
Leena P Ylikontiola, Ville Lehtonen, George K Sándor
BACKGROUND: Autogenous bone graft harvesting from the iliac crest is associated with donor site morbidity. The aim of this report is to describe the use of piezosurgery as an attempt at morbidity reduction. MATERIALS AND METHODS: A piezosurgical handpiece and its selection of tips can easily be accommodated in an iliac crest wound to osteotomize and allow the harvest and delivery of autogenous bone grafts. RESULTS: Corticocancellous blocks or cancellous strips of autogenous bone can be readily harvested using a piezosurgical technique at the anterior iliac crest...
January 2016: Annals of Maxillofacial Surgery
Qi Hu, Jacob Song Kiat Lim, Huan Liu, Yu Fu
Photoacoustic/photothermal spectroscopy is an established technique for trace detection of chemicals and explosives. However, prior sample preparation is required and the analysis is conducted in a sealed space with a high-sensitivity microphone or a piezo sensor coupled with a lock-in amplifier, limiting the technique to applications in a laboratory environment. Due to the aforementioned requirements, traditionally this technique may not be suitable for defense and security applications where the detection of explosives or hazardous chemicals is required in an open environment at a safe standoff distance...
August 22, 2016: Optics Express
Ishwar Prasad Sahu
In the present article we report europium-doped strontium ortho-silicates, namely Sr2 SiO4 :xEu(3+) (x = 1.0, 1.5, 2.0, 2.5 or 3.0 mol%) phosphors, prepared by solid state reaction method. The crystal structures of the sintered phosphors were consistent with orthorhombic crystallography with a Pmna space group. The chemical compositions of the sintered phosphors were confirmed by energy dispersive X-ray spectroscopy (EDS). Thermoluminescence (TL) kinetic parameters such as activation energy, order of kinetics and frequency factors were calculated by the peak shape method...
August 23, 2016: Luminescence: the Journal of Biological and Chemical Luminescence
Alexey Alfonsov, Eiji Ohmichi, Pavel Leksin, Ahmad Omar, Hailong Wang, Sabine Wurmehl, Fengyuan Yang, Hitoshi Ohta
In this work we introduce a new method, which employs commercial piezo-cantilevers, for a ferromagnetic resonance (FMR) detection from thin, nm-size, films. Our setup has an option to rotate the sample in the magnetic field and it operates up to the high microwave frequencies of 160GHz. Using our cantilever based FMR spectrometer we have investigated a set of samples, namely quasi-bulk and 84nm film Co2FeAl0.5Si0.5 samples, 16nm Fe50Ni50 film and 150nm Sr2FeMoO6 film. Low frequency and room temperature test of our setup using 84nm Co2FeAl0...
September 2016: Journal of Magnetic Resonance
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