keyword
https://read.qxmd.com/read/38469119/differentially-expressed-micrornas-targeting-genes-in-key-pathways-in-keratoconus
#21
JOURNAL ARTICLE
Dorota M Nowak-Malczewska, Joanna Swierkowska, Marzena Gajecka
Introduction: Keratoconus (KTCN) is a corneal ectasia, characterized by a progressive thinning and protrusion of the cornea, with a complex etiology involving genetic, behavioral, lifestyle, and environmental factors. Previous studies indicated that microRNAs (miRNAs) could be involved in KTCN pathogenesis. This in silico study aimed to identify precursor microRNAs (pre-miRNAs) differentially expressed in KTCN corneas and to characterize mature miRNAs and their target genes. Materials and methods: Expression levels of pre-miRNAs were retrieved from our previously obtained RNA sequencing data of 25 KTCN and 25 non-KTCN human corneas (PMID:28145428, PMID:30994860)...
2024: Frontiers in Genetics
https://read.qxmd.com/read/38468437/humidity-induced-self-oscillating-and-self-healing-hypercrosslinked-metal-organic-polyhedra-membranes
#22
JOURNAL ARTICLE
Jiamin Li, Zhaoyi Liu, Jinjin Liu, Xue Liu, Yang Luo, Jiajie Liang, Zhenjie Zhang
Designing autonomously oscillating materials is highly desirable for emerging smart material fields but challenging. Herein, a type of hypercrosslinked metal-organic polyhedra (HCMOPs) membranes formed by covalent crosslinking of boronic acid-modified Zr-based MOPs with polyvinyl alcohol (PVA) are rationally designed. In these membranes, MOPs serve as high-connectivity nodes and provide dynamic borate bonds with PVA in hypercrosslinked networks, which can be broken/formed reversibly upon the stimulus of water vapor...
March 11, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38467630/spike-synchrony-as-a-measure-of-gestalt-structure
#23
JOURNAL ARTICLE
Viktoria Zemliak, Julius Mayer, Pascal Nieters, Gordon Pipa
The function of spike synchrony is debatable: some researchers view it as a mechanism for binding perceptual features, others - as a byproduct of brain activity. We argue for an alternative computational role: synchrony can estimate the prior probability of incoming stimuli. In V1, this can be achieved by comparing input with previously acquired visual experience, which is encoded in plastic horizontal intracortical connections. V1 connectivity structure can encode the acquired visual experience in the form of its aggregate statistics...
March 11, 2024: Scientific Reports
https://read.qxmd.com/read/38465583/increase-in-speed-eliminates-duration-expansion-of-a-novel-motion-stimulus
#24
JOURNAL ARTICLE
Shunsuke Sakai, Akira Sarodo, Katsumi Watanabe
A novel motion stimulus is perceived to last longer than the subsequent motion stimulus moving in the opposite direction. A previous study suggested that the discrepancy in the processing latency for different onset types, as measured by reaction time, may play a role in this duration expansion. The present study examined whether the speed of motion stimuli influences this duration expansion. Experiment 1 demonstrated that the duration expansion ceased to occur when the stimulus speed increased. Experiment 2 showed that the increase in the speed reduced the reaction time for various onset types...
March 11, 2024: Perception
https://read.qxmd.com/read/38464715/quantification-of-stimulus-evoked-tactile-allodynia-in-free-moving-mice-by-the-chainmail-sensitivity-test
#25
JOURNAL ARTICLE
Yildirim Ozdemir, Kazuo Nakamoto, Bruno Boivin, Daniel Bullock, Nick A Andrews, Rafael González-Cano, Michael Costigan
Chronic pain occurs at epidemic levels throughout the population. Hypersensitivity to touch, is a cardinal symptom of chronic pain. Despite dedicated research for over a century, quantifying this hypersensitivity has remained impossible at scale. To address these issues, we developed the Chainmail Sensitivity Test (CST). Our results show that control mice spend significantly more time on the chainmail portion of the device than mice subject to neuropathy. Treatment with gabapentin abolishes this difference...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38462986/in-situ-heating-and-electron-tomography-for-materials-research-from-3d-in-situ-2d-to-4d-in-situ-3d
#26
JOURNAL ARTICLE
Satoshi Hata, Shiro Ihara, Hikaru Saito, Mitsuhiro Murayama
In-situ observation has expanded the application of transmission electron microscopy (TEM) and has made a significant contribution to materials research and development for energy, biomedical, quantum, etc. Recent technological developments related to in-situ TEM have empowered the incorporation of three-dimensional observation, which was previously considered incompatible. In this review article, we take up heating as the most commonly used external stimulus for in-situ TEM observation and overview recent in-situ TEM studies...
February 29, 2024: Microscopy
https://read.qxmd.com/read/38461557/enhancement-of-visual-dominance-effects-at-the-response-level-in-children-with-attention-deficit-hyperactivity-disorder
#27
JOURNAL ARTICLE
Xin Li, Shizhong Cai, Yan Chen, Xiaoming Tian, Aijun Wang
Previous studies have widely demonstrated that individuals with attention-deficit/hyperactivity disorder (ADHD) exhibit deficits in conflict control tasks. However, there is limited evidence regarding the performance of children with ADHD in cross-modal conflict processing tasks. The current study aimed to investigate whether children with ADHD have poor conflict control, which has an impact on sensory dominance effects at different levels of information processing under the influence of visual similarity. A total of 82 children aged 7 to 14 years, including 41 children with ADHD and 41 age- and sex-matched typically developing (TD) children, were recruited...
March 9, 2024: Journal of Experimental Child Psychology
https://read.qxmd.com/read/38459678/construction-of-reconfigurable-and-polymorphic-dna-origami-assemblies-with-coiled-coil-patches-and-patterns
#28
JOURNAL ARTICLE
Teng Teng, Julio Bernal-Chanchavac, Nicholas Stephanopoulos, Carlos E Castro
DNA origami nanodevices achieve programmable structure and tunable mechanical and dynamic properties by leveraging the sequence-specific interactions of nucleic acids. Previous advances have also established DNA origami as a useful building block to make well-defined micron-scale structures through hierarchical self-assembly, but these efforts have largely leveraged the structural features of DNA origami. The tunable dynamic and mechanical properties also provide an opportunity to make assemblies with adaptive structures and properties...
March 8, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38459042/ultrafast-underwater-self-healing-piezo-ionic-elastomer-via-dynamic-hydrophobic-hydrolytic-domains
#29
JOURNAL ARTICLE
Zhengyang Kong, Elvis K Boahen, Dong Jun Kim, Fenglong Li, Joo Sung Kim, Hyukmin Kweon, So Young Kim, Hanbin Choi, Jin Zhu, Wu Bin Ying, Do Hwan Kim
The development of advanced materials capable of autonomous self-healing and mechanical stimulus sensing in aquatic environments holds great promise for applications in underwater soft electronics, underwater robotics, and water-resistant human-machine interfaces. However, achieving superior autonomous self-healing properties and effective sensing simultaneously in an aquatic environment is rarely feasible. Here, we present an ultrafast underwater molecularly engineered self-healing piezo-ionic elastomer inspired by the cephalopod's suckers, which possess self-healing properties and mechanosensitive ion channels...
March 8, 2024: Nature Communications
https://read.qxmd.com/read/38459008/abnormal-thermally-stimulated-dynamic-organic-phosphorescence
#30
JOURNAL ARTICLE
He Wang, Huili Ma, Nan Gan, Kai Qin, Zhicheng Song, Anqi Lv, Kai Wang, Wenpeng Ye, Xiaokang Yao, Chifeng Zhou, Xiao Wang, Zixing Zhou, Shilin Yang, Lirong Yang, Cuimei Bo, Huifang Shi, Fengwei Huo, Gongqiang Li, Wei Huang, Zhongfu An
Dynamic luminescence behavior by external stimuli, such as light, thermal field, electricity, mechanical force, etc., endows the materials with great promise in optoelectronic applications. Upon thermal stimulus, the emission is inevitably quenched due to intensive non-radiative transition, especially for phosphorescence at high temperature. Herein, we report an abnormal thermally-stimulated phosphorescence behavior in a series of organic phosphors. As temperature changes from 198 to 343 K, the phosphorescence at around 479 nm gradually enhances for the model phosphor, of which the phosphorescent colors are tuned from yellow to cyan-blue...
March 8, 2024: Nature Communications
https://read.qxmd.com/read/38458616/comparison-of-thermal-and-mechanical-pain-testing-modalities-in-sprague-dawley-and-fischer-344-rats-rattus-norvegicus
#31
JOURNAL ARTICLE
James F McNew, Daniel J Davis, Kristin N Grimsrud, Elizabeth C Bryda
While rodents are used extensively for studying pain, there is a lack of reported direct comparisons of thermal and mechanical pain testing methods in rats of different genetic backgrounds. Understanding the range of interindividual variability of withdrawal thresholds and thermal latencies based on these testing methods and/or genetic background is important for appropriate experimental design. Testing was performed in two common rat genetic backgrounds: outbred Sprague-Dawley (SD) and inbred Fischer 344 (F344)...
March 8, 2024: Journal of the American Association for Laboratory Animal Science: JAALAS
https://read.qxmd.com/read/38457951/prime-saliency-in-semantic-priming-with-18-month-olds
#32
JOURNAL ARTICLE
Nicola Gillen, Armando Quetzalcóatl Angulo-Chavira, Kim Plunkett
This study investigated semantic priming in 18-month-old infants using the inter-modal priming technique, focusing on the effects of prime repetition on saliency. Our findings showed that prime repetition led to longer looking times at target referents for related primes compared to unrelated primes, supporting the existence of a structured semantic system in infants as young as 18 months. The results are consistent with both Spreading Activation and Distributed models of semantic priming. Additionally, our findings highlighted the impact of prime-target stimulus onset asynchronies (SOAs) on priming effects, revealing positive, negative, or no priming effects depending on the chosen SOA...
March 7, 2024: Cognition
https://read.qxmd.com/read/38456864/on-the-physiology-of-the-sensory-collapse-test
#33
REVIEW
James E McCarthy, Pradeep Attaluri, Peter Nicksic
The sensory-collapse test (formerly the scratch-collapse test) is a physical examination finding describing a momentary inhibition of external shoulder rotation following light stimulation of an injured nerve in the ipsilateral limb. Similar to other physical examination tests designed to interrogate nerve compression, such as the Phalen or Tinel tests, its test characteristics demonstrate variation. There remains speculation about the test's existence and anatomic basis. The literature of mammalian reflex physiology was reviewed with an emphasis on the sensory pathways from the upper extremity, the extrapyramidal system, and newly discovered pathways and concepts of nociception...
March 7, 2024: Journal of Hand Surgery
https://read.qxmd.com/read/38455431/effect-of-high-intensity-interval-exercise-versus-continuous-low-intensity-aerobic-exercise-with-blood-flow-restriction-on-psychophysiological-responses-a-randomized-crossover-study
#34
JOURNAL ARTICLE
Victor S de Queiros, Nicholas Rolnick, Angelo Sabag, Phelipe Wilde, Thiago Peçanha, Rodrigo Ramalho Aniceto, Roberto Felipe Câmara Rocha, Douglas Z Delgado, Breno Guilherme de Araújo Tinôco Cabral, Paulo Moreira Silva Dantas
This study compared the effect of continuous low-intensity aerobic exercise with blood flow restriction (LI-AE-BFR) versus high-intensity interval exercise (HIIE), matching total external mechanical work between conditions, on perceptual (exertion, pain, affective and pleasure) and physiological responses (heart rate [HR], blood lactate [BL] and muscle fatigue). Ten healthy untrained men (25.6 ± 3.78 years old; 75.02 ± 12.02 kg; 172.2 ± 6.76 cm; 24.95 ± 3.16 kg/m²) completed three visits to the laboratory...
March 2024: Journal of Sports Science & Medicine
https://read.qxmd.com/read/38453946/the-mechanisms-underlying-conditioning-of-phantom-percepts-differ-between-those-with-hallucinations-and-synesthesia
#35
JOURNAL ARTICLE
Magdalena Del Rio, Eren Kafadar, Victoria Fisher, Rhys D'Costa, Albert Powers, Jamie Ward
There are many different kinds of 'phantom' percepts but it is unknown whether they are united by common mechanisms. For example, synaesthesia (e.g., numbers evoking colour) and hallucinations appear conceptually and phenomenologically similar: both result in a percept that does not have an environmental correlate. Here, people with synaesthesia (n = 66) performed a conditioned hallucinations paradigm known to be sensitive to hallucination susceptibility, and we asked whether synaesthetes would show the same behavioural profile as hallucinators in this task...
March 7, 2024: Scientific Reports
https://read.qxmd.com/read/38453902/social-buffering-in-rats-reduces-fear-by-oxytocin-triggering-sustained-changes-in-central-amygdala-neuronal-activity
#36
JOURNAL ARTICLE
Chloe Hegoburu, Yan Tang, Ruifang Niu, Supriya Ghosh, Rodrigo Triana Del Rio, Isabel de Araujo Salgado, Marios Abatis, David Alexandre Mota Caseiro, Erwin H van den Burg, Christophe Grundschober, Ron Stoop
The presence of a companion can reduce fear, but the neural mechanisms underlying this social buffering of fear are incompletely known. We studied social buffering of fear in male and female, and its encoding in the amygdala of male, auditory fear-conditioned rats. Pharmacological, opto,- and/or chemogenetic interventions showed that oxytocin signaling from hypothalamus-to-central amygdala projections underlied fear reduction acutely with a companion and social buffering retention 24 h later without a companion...
March 7, 2024: Nature Communications
https://read.qxmd.com/read/38453673/amino-acid-encoded-bioinspired-supramolecular-self-assembly-of-multimorphological-nanocarriers
#37
JOURNAL ARTICLE
Yifan Huang, Guokun Yang, Zian Yu, Tong Tong, Yan Huang, Qianzijing Zhang, Yajian Hong, Jun Jiang, Guozhen Zhang, Yue Yuan
Supramolecular self-assembly has emerged as an efficient tool to construct well-organized nanostructures for biomedical applications by small organic molecules. However, the physicochemical properties of self-assembled nanoarchitectures are greatly influenced by their morphologies, mechanical properties, and working mechanisms, making it challenging to design and screen ideal building blocks. Herein, using a biocompatible firefly-sourced click reaction between the cyano group of 2-cyano-benzothiazole (CBT) and the 1,2-aminothiol group of cysteine (Cys), an amino-acid-encoded supramolecular self-assembly platform Cys(SEt)-X-CBT (X represents any amino acid) is developed to incorporate both covalent and noncovalent interactions for building diverse morphologies of nanostructures with bioinspired response mechanism, providing a convenient and rapid strategy to construct site-specific nanocarriers for drug delivery, cell imaging, and enzyme encapsulation...
March 7, 2024: Small
https://read.qxmd.com/read/38451699/proximity-to-rewards-modulates-parameters-of-effortful-control-exertion
#38
JOURNAL ARTICLE
Sean Devine, Mathieu Roy, Ulrik Beierholm, A Ross Otto
The now-classic goal-gradient hypothesis posits that organisms increase effort expenditure as a function of their proximity to a goal. Despite nearly a century having passed since its original formulation, goal-gradient-like behavior in human cognitive performance remains poorly understood: Are we more willing to engage in costly cognitive processing when we are near, versus far, from a goal state? Moreover, the computational mechanisms underpinning these potential goal-gradient effects-for example, whether goal proximity affects fidelity of stimulus encoding, response caution, or other identifiable mechanisms governing speed and accuracy-are unclear...
March 7, 2024: Journal of Experimental Psychology. General
https://read.qxmd.com/read/38449740/aqueous-extract-of-swietenia-macrophylla-leaf-exerts-an-anti-inflammatory-effect-in-a-murine-model-of-parkinson-s-disease-induced-by-6-ohda
#39
JOURNAL ARTICLE
Váldina Solimar Lopes Cardoso, Anderson Valente-Amaral, Rayan Fidel Martins Monteiro, Clarina Loius Silva Meira, Natália Silva de Meira, Milton Nascimento da Silva, João de Jesus Viana Pinheiro, Gilmara de Nazareth Tavares Bastos, João Soares Felício, Elizabeth Sumi Yamada
INTRODUCTION: Parkinson's disease affects 2% of the population aged over 65 years and is the second most common neurodegenerative disorder in the general population. The appearance of motor symptoms is associated with the degeneration of dopaminergic neurons in the nigrostriatal pathway. Clinically significant nonmotor symptoms are also important for severe disability with disease progression. Pharmacological treatment with levodopa, which involves dopamine restitution, results in a temporary improvement in motor symptoms...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38449334/developmental-programming-by-prenatal-sounds-insights-into-possible-mechanisms
#40
JOURNAL ARTICLE
Mylene M Mariette
In recent years, the impact of prenatal sound on development, notably for programming individual phenotypes for postnatal conditions, has increasingly been revealed. However, the mechanisms through which sound affects physiology and development remain mostly unexplored. Here, I gather evidence from neurobiology, developmental biology, cellular biology and bioacoustics to identify the most plausible modes of action of sound on developing embryos. First, revealing often-unsuspected plasticity, I discuss how prenatal sound may shape auditory system development and determine individuals' later capacity to receive acoustic information...
March 7, 2024: Journal of Experimental Biology
keyword
keyword
35023
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.