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https://www.readbyqxmd.com/read/29679296/methylmercury-reduces-synaptic-transmission-and-neuronal-excitability-in-rat-hippocampal-slices
#1
J Gutiérrez, A M Baraibar, E Albiñana, P Velasco, J M Solís, J M Hernández-Guijo
In a previous study, we pointed out that the neurotoxic action evoked by methylmercury (MeHg), a potent environmental pollutant responsible for fatal food poisoning, is associated with alterations of cellular excitability by irreversible blockade of sodium and calcium currents. Here, we investigated the MeHg effects on synaptic transmission and neuronal plasticity using extracellular field recording in CA1 area of rat hippocampal slices. MeHg caused a fast and drastic depression of evoked field excitatory postsynaptic potentials (fEPSPs) in a concentration-dependent manner with an IC50 of 25...
April 21, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29678220/analysis-of-the-vidas-%C3%A2-staph-enterotoxin-iii-set3-for-detection-of-staphylococcal-enterotoxins-g-h-and-i-in-foods
#2
Jennifer M Hait, Angela T Nguyen, Sandra M Tallent
Background : Staphylococcal food poisoning (SFP) frequently causes illnesses worldwide. SFP occurs from the ingestion of staphylococcal enterotoxins (SEs) preformed in foods by enterotoxigenic strains of Staphylococcus species, primarily S. aureus . SEG, SEH, and SEI induce emesis and have been implicated in outbreaks. Immunological-based methods are deemed the most practical methods for the routine analysis of SEs in foods given their ease of use, sensitivity, specificity, and commercial availability. These kits are routinely used to test for SEA-SEE...
April 20, 2018: Journal of AOAC International
https://www.readbyqxmd.com/read/29676900/beryllium-free-nonlinear-optical-crystals-a-3-ba-3-li-2-ga-4-b-6-o-20-f-a-k-and-rb-members-of-the-sr-2-be-2-bo-3-2-o-family-with-a-strong-covalent-connection-between-the-%C3%A2-2-li-2-ga-4-b-6-o-20-f-9-double-layers
#3
Xianghe Meng, Fei Liang, Mingjun Xia, Zheshuai Lin
Two gallium-based borates, K3 Ba3 Li2 Ga4 B6 O20 F (I) and Rb3 Ba3 Li2 Ga4 B6 O20 F (II), have been successfully grown in the M2 O (M = K, Rb)-LiF-B2 O3 flux. They can be recognized as the element cosubstitutions of Sr for K/Rb and Ba and of Be for Li and Ga from Sr2 Be2 (BO3 )2 O (SBBO), which uses poisonous beryllium oxide during the synthesis and crystal growth process and also exhibits the problem of structural instability. The isostructural borates crystallize into the noncentrosymmetric space group P6̅2 c, with a = 8...
April 20, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29675076/abrus-precatorius-poisoning-and-central-pontine-myelinolysis
#4
Sumantra Sarkar, Kaushambi Basu, Jayati Das, Supratim Datta
Accidental poisoning with Abrus precatorius (AP) can rarely produce neurological complication due to its toxic principle "Abrin". The authors report such a case in a 2-year old child, who subsequently developed central pontine myelinolysis, an association, to the best of the author's knowledge, has never been reported in literature.
October 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29674463/adverse-weather-triggers-cases-of-rhododendron-poisoning-in-sheep
#5
(no author information available yet)
No abstract text is available yet for this article.
April 21, 2018: Veterinary Record
https://www.readbyqxmd.com/read/29674040/speciation-analysis-of-inorganic-arsenic-by-magnetic-solid-phase-extraction-on-line-with-inductively-coupled-mass-spectrometry-determination
#6
P Montoro Leal, E Vereda Alonso, M M López Guerrero, M T Siles Cordero, J M Cano Pavón, A García de Torres
Arsenic, one of the main environmental pollutants and potent natural poison, is a chemical element that is spread throughout the Earth's crust. It is well known that the toxicity of arsenic is highly dependent on its chemical forms. Generally, the inorganic species are more toxic than its organics forms, and As(III) is 60 times more toxic than As(V). In environmental waters, arsenic exists predominantly in two chemical forms: As(III) and As(V). In view of these facts, fast, sensitive, accurate and simple analytical methods for the speciation of inorganic arsenic in environmental waters are required...
July 1, 2018: Talanta
https://www.readbyqxmd.com/read/29673693/profiling-in-wildlife-crime-recovery-of-human-dna-deposited-outside
#7
K Mcleish, S Ferguson, C Gannicliffe, S Campbell, P I T Thomson, L M I Webster
Incidents of bird of prey persecution receive a lot of media coverage in the UK, with investigations rarely recovering sufficient evidence to proceed to prosecution. One of the main challenges is to identify a suspect, as these offences are carried out in remote locations without witnesses, and crime scenes may not be found for days. However, traps, poisoned baits and bird of prey carcasses can be recovered from these crime scenes. This study aimed to determine whether reportable human DNA profiles could be recovered from any of these substrates after periods of time outside...
April 4, 2018: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/29673413/seven-cases-of-probable-endotoxin-poisoning-related-to-contaminated-glutathione-infusions
#8
T Johnstone, E Quinn, S Tobin, R Davis, Z Najjar, B Battye, L Gupta
We report seven cases of probable endotoxin poisoning linked to contaminated compounded glutathione. Five of the cases were using the infusions for treatment of Lyme disease highlighting the risks of using compounded sterile preparations for unapproved indications, especially if the quality of source products cannot be assured.
April 20, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29673294/prophylactic-use-of-steroids-and-antibiotics-in-acute-hydrocarbon-poisoning-in-children
#9
Saibal Das, Sapan Kumar Behera, Alphienes Stanley Xavier, Sandhiya Selvarajan
Ingestion of hydrocarbons is a common cause of childhood poisoning in low and middle-income countries. Although mild ingestions are usually devoid of complications, the morbidity and mortality associated with such poisoning are primarily related to pulmonary aspiration. Subsequent complications, most importantly, secondary bacterial infections can worsen the clinical condition. Standard treatment protocol for acute accidental hydrocarbon poisoning does not advocate routine use of steroids or antibiotics. However, some studies have demonstrated beneficial effects of prophylactic steroid and antibiotic to prevent chemical pneumonitis...
January 1, 2018: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29673186/identification-expression-analysis-of-the-hsf-family-and-characterization-of-class-a4-in-sedum-alfredii-hance-under-cadmium-stress
#10
Shuang-Shuang Chen, Jing Jiang, Xiao-Jiao Han, Yun-Xing Zhang, Ren-Ying Zhuo
Sedum alfredii Hance, a cadmium (Cd)/zinc (Zn)/lead (Pb) co-hyperaccumulating species, is a promising phytoremediation candidate because it accumulates substantial amounts of heavy metal ions without showing any obvious signs of poisoning. The heat shock transcription factor (Hsf) family plays crucial roles in plant growth, development, and stress responses. Although the roles of some Hsfs in abiotic stress have been well studied in model plants, the Hsf family has not been systematically investigated in heavy metal hyperaccumulators...
April 17, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29672985/the-impact-of-buprenorphine-and-methadone-on-mortality-a-primary-care-cohort-study-in-the-united-kingdom
#11
Matthew Hickman, Colin Steer, Kate Tilling, Aaron G Lim, John Marsden, Tim Millar, John Strang, Maggie Telfer, Peter Vickerman, John Macleod
AIMS: To estimate whether opioid substitution treatment (OST) with buprenorphine or methadone is associated with a greater reduction in the risk of all-cause mortality (ACM) and opioid drug-related poisoning (DRP) mortality. DESIGN: Cohort study with linkage between clinical records from Clinical Practice Research Datalink and mortality register. SETTING: UK primary care. PARTICIPANTS: A total of 11 033 opioid-dependent patients who received OST from 1998 to 2014, followed-up for 30 410 person-years...
April 19, 2018: Addiction
https://www.readbyqxmd.com/read/29672619/ros-and-trypanosoma-cruzi-fuel-to-infection-poison-to-the-heart
#12
REVIEW
Claudia N Paiva, Emiliano Medei, Marcelo T Bozza
The activation of macrophage respiratory burst in response to infection with Trypanosoma cruzi inflicts oxidative damage to the host's tissues. For decades, the role of reactive oxygen species (ROS) in the elimination of T. cruzi was taken for granted, but recent evidence suggests parasite growth is stimulated in oxidative environments. It is still a matter of debate whether indeed oxidative environments provide ideal conditions (e.g., iron availability in macrophages) for T. cruzi growth and whether indeed ROS signals directly to stimulate growth...
April 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29672561/rich-table-but-short-life-diffuse-idiopathic-skeletal-hyperostosis-in-danish-astronomer-tycho-brahe-1546-1601-and-its-possible-consequences
#13
Sacha Kacki, Petr Velemínský, Niels Lynnerup, Sylva Kaupová, Alizé Lacoste Jeanson, Ctibor Povýšil, Martin Horák, Jan Kučera, Kaare Lund Rasmussen, Jaroslav Podliska, Zdeněk Dragoun, Jiří Smolík, Jens Vellev, Jaroslav Brůžek
The exhumation of Danish astronomer Tycho Brahe (1546-1601) was performed in 2010 to verify speculative views on the cause of his death. Previous analyses of skeletal and hair remains recovered from his grave refuted the presumption that he died from poisoning. These studies also outlined the possibility that he actually died from an acute illness, echoing the rather vague and inaccurate testimony of some historical records. We performed a detailed paleopathological analysis of Tycho Brahe's skeletal remains, along with a reconstruction of his diet based on carbon and nitrogen stable isotopes analysis and an estimate of his physical status (relative body fat) based on medullar and cortical dimensions of the femoral shaft...
2018: PloS One
https://www.readbyqxmd.com/read/29672479/protracted-outbreak-of-salmonella-newport-infections-linked-to-ground-beef-possible-role-of-dairy-cows-21-states-2016-2017
#14
Katherine E Heiman Marshall, Mackenzie Tewell, Selam Tecle, Molly Leeper, Jennifer Sinatra, Bonnie Kissler, Adrienne Fung, Kerri Brown, Darlene Wagner, Eija Trees, Kelley B Hise, Vishnu Chaturvedi, Linda K Schlater, Brenda R Morningstar-Shaw, Laura Whitlock, Kristin Holt, Karen Becker, Megin Nichols, Ian T Williams, Michael Jhung, Matthew E Wise, Laura Gieraltowski
In January 2017, CDC identified a cluster of Salmonella enterica serotype Newport infections with isolates sharing an indistinguishable pulsed-field gel electrophoresis (PFGE) pattern, JJPX01.0010 (pattern 10), through PulseNet, the national molecular subtyping network for foodborne disease surveillance. This report summarizes the investigation by CDC, state and local health and agriculture departments, and the U.S. Department of Agriculture's Food Safety and Inspection Service (USDA-FSIS) and discusses the possible role of dairy cows as a reservoir for strains of Salmonella that persistently cause human illness...
April 20, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29672171/prevalence-of-enterotoxin-genes-in-staphylococcus-aureus-isolates-from-pork-production
#15
Yang Zhang, Yage Wang, Rujian Cai, Lei Shi, Chunling Li, He Yan
In this study, 130 Staphylococcus aureus isolates from samples associated with pork production were tested for prevalence of 18 staphylococcal enterotoxin (SE) genes. Approximately 94.6% (123/130) of isolates from different stages of pork production harbored one or more SE genes forming 37 different enterotoxin gene profiles. Seb was present in 60.0% of the S. aureus isolates, the highest among the genes tested. The genes, sed, sej, seo, sep, ser, and seu, were not found. The five classical SE genes (including sea, seb, sec, sed, see) had lower prevalence than the egc gene cluster (seg, sei, sem, sen, seo, or seu)...
April 19, 2018: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/29671588/absolute-configuration-and-pharmacology-of-the-poison-frog-alkaloid-phantasmidine
#16
Richard W Fitch, Barry B Snider, Quan Zhou, Bruce M Foxman, Anshul A Pandya, Jerrel L Yakel, Thao T Olson, Nour Al-Muhtasib, Yingxian Xiao, Kevin D Welch, Kip E Panter
Phantasmidine, a rigid congener of the well-known nicotinic acetylcholine receptor agonist epibatidine, is found in the same species of poison frog ( Epipedobates anthonyi). Natural phantasmidine was found to be a 4:1 scalemic mixture, enriched in the (2a R,4a S,9a S) enantiomer by chiral-phase LC-MS comparison to the synthetic enantiomers whose absolute configurations were previously established by Mosher's amide analysis. The major enantiomer has the opposite S configuration at the benzylic carbon to natural epibatidine, whose benzylic carbon is R...
April 19, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29671127/quantitative-analysis-of-the-anti-inflammatory-activity-of-orengedokuto-ii-berberine-is-responsible-for-the-inhibition-of-no-production
#17
Naohiro Oshima, Tomofumi Shimizu, Yuji Narukawa, Noriyasu Hada, Fumiyuki Kiuchi
Orengedokuto is a Kampo formula that has been used for removing "heat" and "poison" to treat inflammation, hypertension, gastrointestinal disorders, and liver and cerebrovascular diseases. We report here our analysis of the anti-inflammatory effect of the component crude drugs of orengedokuto and their constituents using the inhibition of nitric oxide (NO) production in the murine macrophage-like cell line J774.1. An initial comparison of NO production inhibitory activities of the extracts of the component crude drugs and their combinations revealed that the activity could be attributed to Phellodendron Bark and Coptis Rhizome...
April 18, 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/29670134/detection-of-functional-protein-domains-by-unbiased-genome-wide-forward-genetic-screening
#18
Mareike Herzog, Fabio Puddu, Julia Coates, Nicola Geisler, Josep V Forment, Stephen P Jackson
Establishing genetic and chemo-genetic interactions has played key roles in elucidating mechanisms by which certain chemicals perturb cellular functions. In contrast to gene disruption/depletion strategies to identify mechanisms of drug resistance, searching for point-mutational genetic suppressors that can identify separation- or gain-of-function mutations has been limited. Here, by demonstrating its utility in identifying chemical-genetic suppressors of sensitivity to the DNA topoisomerase I poison camptothecin or the poly(ADP-ribose) polymerase inhibitor olaparib, we detail an approach allowing systematic, large-scale detection of spontaneous or chemically-induced suppressor mutations in yeast or haploid mammalian cells in a short timeframe, and with potential applications in other haploid systems...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29669989/chronic-manganese-toxicity-associated-with-voltage-gated-potassium-channel-complex-antibodies-in-a-relapsing-neuropsychiatric-disorder
#19
Cyrus S H Ho, Roger C M Ho, Amy M L Quek
Heavy metal poisoning is a rare but important cause of encephalopathy. Manganese (Mn) toxicity is especially rare in the modern world, and clinicians’ lack of recognition of its neuropsychiatric manifestations can lead to misdiagnosis and mismanagement. We describe the case of a man who presented with recurrent episodes of confusion, psychosis, dystonic limb movement and cognitive impairment and was initially diagnosed with anti-voltage-gated potassium channel (VGKC) complex limbic encephalitis in view of previous positive autoantibodies...
April 18, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29669641/-yellow-dirt-a-poisoned-land-and-the-betrayal-of-the-navajos
#20
Lucy Graham
No abstract text is available yet for this article.
April 1, 2018: Creative Nursing
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