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https://www.readbyqxmd.com/read/28806750/characterization-of-novel-bangle-lectin-from-photorhabdus-asymbiotica-with-dual-sugar-binding-specificity-and-its-effect-on-host-immunity
#1
Gita Jančaříková, Josef Houser, Pavel Dobeš, Gabriel Demo, Pavel Hyršl, Michaela Wimmerová
Photorhabdus asymbiotica is one of the three recognized species of the Photorhabdus genus, which consists of gram-negative bioluminescent bacteria belonging to the family Morganellaceae. These bacteria live in a symbiotic relationship with nematodes from the genus Heterorhabditis, together forming a complex that is highly pathogenic for insects. Unlike other Photorhabdus species, which are strictly entomopathogenic, P. asymbiotica is unique in its ability to act as an emerging human pathogen. Analysis of the P...
August 14, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28806697/photoelectron-spectra-and-biological-activity-of-cinnamic-acid-derivatives-revisited
#2
Igor Novak, Leo Klasinc, Sean P McGlynn
The electronic structures of several derivatives of cinnamic acid have been studied by UV photoelectron spectroscopy (UPS) and Green's function quantum chemical calculations. The spectra reveal the presence of dimers in the gas phase for p-coumaric and ferulic acids. The electronic structure analysis has been related to the biological properties of these compounds through the analysis of some structure-activity relationships (SAR).
August 10, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28806675/biotransformation-of-nsaids-by-pig-liver-microsomes-in%C3%A2-vitro-kinetics-metabolites-identification-and-toxicity-prediction
#3
Liyun Ma, Xiaojing Mao, Xiao Sun, Li Xu
Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most frequently used pharmaceuticals in animals. In the current study, the biotransformation of five NSAIDs by pig liver microsomes (PLMs) was studied. The pseudo-first-order kinetics mode was obtained for the metabolization of the studied NSAIDs by PLMs in vitro. The metabolites were identified by high performance liquid chromatography with a high-resolution LTQ-Orbitrap mass spectrometry. The hydroxylation of benzene was confirmed to be the dominating metabolic pathway...
August 8, 2017: Chemosphere
https://www.readbyqxmd.com/read/28806324/comparison-of-the-quality-of-informal-care-of-community-dwelling-taiwanese-older-people
#4
Chia-Yi Chiao, Yen-Ju Lin, Chiu-Yueh Hsiao
BACKGROUND: With social structures changing and the average life-span of individuals increasing, Taiwan is experiencing a steady rise in its elderly population. Thus, caring for older parentsis an urgent problem. Many foreign caregivers have been hired tocare for older parents.However, measuring the quality ofinformal care has not yet been fully explored in Taiwan, particularly among older people who are cared for by foreign caregivers in home settings. PURPOSE: The purposes of this study were to understand the differences in quality of care for older Taiwanese and to explore the predictors of quality of care in two types of caregiving...
August 12, 2017: Journal of Nursing Research: JNR
https://www.readbyqxmd.com/read/28806094/the-relationship-of-throwing-arm-mechanics-and-elbow-varus-torque-within-subject-variation-for-professional-baseball-pitchers-across-82-000-throws
#5
Christopher L Camp, Travis G Tubbs, Glenn S Fleisig, Joshua S Dines, David M Dines, David W Altchek, Brittany Dowling
BACKGROUND: Likely due to the high level of strain exerted across the elbow during the throwing motion, elbow injuries are on the rise in baseball. To identify at-risk athletes and guide postinjury return-to-throw programs, a better understanding of the variables that influence elbow varus torque is desired. PURPOSE: To describe the within-subject relationship between elbow varus torque and arm slot and arm rotation in professional baseball pitchers. STUDY DESIGN: Descriptive laboratory study...
August 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28806079/pilot-in-vivo-structure-activity-relationship-of-dihydromethys-ticin-in-blocking-4-methylnitrosamino-1-3-pyridyl-1-butanone-induced-o6-methylguanine-and-lung-tumor-in-a-j-mice
#6
Manohar Puppala, Sreekanth C Narayanapillai, Pablo Leitzman, Haifeng Sun, Pramod Upadhyaya, M Gerard O'Sullivan, Stephen S Hecht, Chengguo Xing
(+)-Dihydromethysticin was recently identified as a promising lung cancer chemopreventive agent while (+)-dihydrokavain was completely ineffective. A pilot in vivo structure-activity relationship (SAR) was explored, evaluating the efficacy of its analogs in blocking 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced short-term O6-methylguanine and long-term adenoma formation in the lung tissues in A/J mice. Both results revealed cohesive SARs, demonstrating that the methylenedioxy functional group in DHM is essential while the lactone functional group tolerates modifications...
August 14, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28806053/de-blurring-signal-network-dynamics
#7
Dominic Kamps, Leif Dehmelt
To orchestrate the function and development of multicellular organisms, cells integrate intra- and extracellular information. This information is processed via signal networks in space and time, steering dynamic changes in cellular structure and function. Defects in those signal networks can lead to developmental disorders or cancer. However, experimental analysis of signal networks is challenging as their state changes dynamically and differs between individual cells. Thus, causal relationships between network components are blurred if lysates from large cell populations are analyzed...
August 14, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28806050/linking-high-throughput-screens-to-identify-moas-and-novel-inhibitors-of-mycobacterium-tuberculosis-dihydrofolate-reductase
#8
John P Santa Maria, Yumi Park, Lihu Yang, Nicholas Murgolo, Michael D Altman, Paul Zuck, Greg Adam, Chad Chamberlin, Peter Saradjian, Peter Dandliker, Helena I M Boshoff, Clifton E Barry, Charles Garlisi, David B Olsen, Katherine Young, Meir Glick, Elliott Nickbarg, Peter S Kutchukian
Though phenotypic and target-based high-throughput screening approaches have been employed to discover new antibiotics, the identification of promising therapeutic candidates remains challenging. Each approach provides different information, and understanding their results can provide hypotheses for mechanism of action (MoA) and reveal actionable chemical matter. Here we describe a framework for identifying efficacy targets of bioactive compounds. High throughput biophysical profiling against a broad range of targets coupled with machine learning is employed to identify chemical features with predicted efficacy targets for a given phenotypic screen...
August 14, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28805883/a-novel-objective-chute-score-interacts-with-monensin-to-affect-growth-of-receiving-cattle
#9
K A Bruno, E S Vanzant, A W Altman, M Kudupoje, K A Vanzant, K R McLeod
Growth in cattle may be related to animal temperament via alterations in intake or feed conversion. However, temperament is ill-defined, and different temperament measures may relate differently to production traits or interact with dietary factors in their effects. To examine relationships between diet, temperament, growth, and health, 160 crossbred steers (262 ± 22 kg) were used in a 56-d RCBD experiment with a 2 × 2 × 2 factorial treatment structure with 5 pens/treatment. Steers were pen fed a corn silage-based diet with or without monensin (41...
August 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28805748/synthesis-and-evaluation-of-novel-benzofuran-derivatives-as-selective-sirt2-inhibitors
#10
Yumei Zhou, Huaqing Cui, Xiaoming Yu, Tao Peng, Gang Wang, Xiaoxue Wen, Yunbo Sun, Shuchen Liu, Shouguo Zhang, Liming Hu, Lin Wang
A series of benzofuran derivatives were designed and synthesized, and their inhibitory activites were measured against the SIRT1-3. The enzymatic assay showed that all the compounds showed certain anti-SIRT2 activity and selective over SIRT1 and SIRT3 with IC50 (half maximal inhibitory concentration) values at the micromolar level. The preliminary structure-activity relationships were analyzed and the binding features of compound 7e (IC50 3.81 µM) was predicted using the CDOCKER program. The results of this research could provide informative guidance for further optimizing benzofuran derivatives as potent SIRT2 inhibitors...
August 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28803048/novel-unsaturated-glycyrrhetic-acids-derivatives-design-synthesis-and-anti-inflammatory-activity
#11
Bo Li, Shi Cai, Yong-An Yang, Shi-Chao Chen, Rui Chen, Jing-Bo Shi, Xin-Hua Liu, Wen-Jian Tang
To develop novel anti-inflammatory agents, a series of unsaturated glycyrrhetic acids were designed, synthesized and evaluated for anti-inflammatory activity using RAW264.7 cells. The structure-activity relationship (SAR) of NO inhibitory activity was analyzed. α,β-Unsaturated glycyrrhetic acids showed better activity, among them, compounds 6k and 6l with piperazine unit exhibited the most potent nitric oxide (NO) and interleukin-6 (IL-6) inhibitory activity (IC50 = 13.3 and 15.5 μM respectively). Furthermore, compound 6k could also significantly suppress LPS-induced iNOS and COX-2 expression and IL-6 production through MAPKs and NF-kB signaling pathway...
August 3, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28803047/puromycin-based-inhibitors-of-aminopeptidases-for-the-potential-treatment-of-hematologic-malignancies
#12
Rohit Singh, Jessica Williams, Robert Vince
Substantial progress has been described in the study of puromycin and its analogs for antibiotic properties. However, the peptidase inhibitory activity of related analogs has not been explored as extensively. Specifically, inhibiting aminopeptidases for achieving antitumor effect has been sparsely investigated. Herein, we address this challenge by reporting the synthesis of a series of analogs based on the structural template of puromycin. We also present exhaustive biochemical and in vitro analyses in support of our thesis...
July 26, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28803045/discovery-of-novel-3-hydroxyalkoxy-2-alkylchromen-4-one-analogs-as-interleukin-5-inhibitors
#13
Pulla Reddy Boggu, Eeda Venkateswararao, Manoj Manickam, Youngsoo Kim, Sang-Hun Jung
A series of novel chromen-4-one analogs 9a-d and 10a-u was designed, synthesized and evaluated for their IL-5 inhibitory activity. Most of the chromen-4-one analogs showed strong inhibitory activity in low micro molar potency. Among them, 5-(cyclohexylmethoxy)-3-(3-hydroxypropoxy)-2-isopropyl-4H-chromen-4-one (10t, 90.0% inhibition at 30 μM, IC50 = 5.5 μM, CLogP = 4.76887) and 2-cyclohexyl-5-(cyclohexylmethoxy)-3-(3-hydroxypropoxy)-4H-chromen-4-one (10u, 95.5% inhibition at 30 μM, IC50 = 3.0 μM, CLogP = 5...
July 29, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28802300/media-exposure-and-parental-mediation-on-fast-food-consumption-among-children-in-metropolitan-and-suburban-indonesian
#14
May O Lwin, Shelly Malik, Hardinsyah Ridwan, Cyndy Sook Sum Au
BACKGROUND AND OBJECTIVES: Fast-food companies have been reproached for rising obesity levels due to aggressive marketing tactics targeted at children. They have countered that parents should be held responsible considering their critical role as nutritional gatekeepers. This study examined the comparative effects of media exposure and parental mediation on Indonesian children's fast food consumption and how the effects compare in the metropolitan versus suburban areas. METHODS AND STUDY DESIGN: The sample consisted of 394 child-mother pairs comprising grade three and four children and their mothers from two schools each in Jakarta and Bogor representing 40...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28802214/the-relationship-between-physical-activity-meaning-in-life-and-subjective-vitality-in-community-dwelling-older-adults
#15
Haewon Ju
The present study examined the potential contribution of meaning in life to the relationship between physical activity and subjective vitality in older adults. Two-hundred and fifty community-dwelling elders completed the instruments assessing physical activity, meaning in life, and subjective vitality. Results from structural equation modeling indicated that physical activity was positively associated with both meaning in life and subjective vitality. Further, the relationship between physical activity and vitality was partially mediated by meaning in life...
August 2, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28802121/identification-of-highly-potent-n-acylethanolamine-acid-amidase-naaa-inhibitors-optimization-of-the-terminal-phenyl-moiety-of-oxazolidone-derivatives
#16
Yuhang Li, Qi Chen, Longhe Yang, Yanting Li, Yang Zhang, Yan Qiu, Jie Ren, Canzhong Lu
N-acylethanolamine acid amidase (NAAA) is a cysteine hydrolase that participates in the deactivation of fatty acid ethanolamides, such as palmitoylethanolamide (PEA). NAAA inhibition may provide a potential therapeutic strategy for the treatment of diseases in which higher PEA level is desired. In the present study, we reported the structure-activity relationship (SAR) studies for oxazolidone derivatives as NAAA inhibitors. A series of substituents or alkyl replacements for the terminal phenyl ring of oxazolidone derivatives were examined...
August 3, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28801892/adaptive-neuro-fuzzy-inference-system-applied-qsar-with-bond-dissociation-energy-for-antioxidant-activities-of-phenolic-compounds
#17
Changho Jhin, Chu Won Nho, Keum Taek Hwang
The aim of this study was to develop quantitative structure-activity relationship (QSAR) models for predicting antioxidant activities of phenolic compounds. The bond dissociation energy of O-H bond (BDE) was calculated by semi-empirical quantum chemical methods. As a new parameter for QSAR models, sum of reciprocals of BDE of enol and phenol groups (X BDE ) was calculated. Significant correlations were observed between X BDE and antioxidant activities, and X BDE was introduced as a parameter for developing QSAR models...
August 11, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28801209/compromised-autophagy-precedes-meniscus-degeneration-and-cartilage-damage-in-mice
#18
Jeanie Kwok Meckes, Beatriz Caramés, Merissa Olmer, William B Kiosses, Shawn P Grogan, Martin K Lotz, Darryl D D'Lima
OBJECTIVE: Autophagy is a cellular homeostasis mechanism that facilitates normal cell function and survival. Objectives of this study were to determine associations between autophagic responses with meniscus injury, joint aging, and osteoarthritis (OA), and to establish the temporal relationship with structural changes in menisci and cartilage. METHODS: Constitutive activation of autophagy during aging was measured in GFP-LC3 transgenic reporter mice between 6 and 30 months...
August 8, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28800457/fucosylated-chondroitin-sulfate-oligosaccharides-exert-anticoagulant-activity-by-targeting-at-intrinsic-tenase-complex-with-low-fxii-activation-importance-of-sulfation-pattern-and-molecular-size
#19
Junhui Li, Shan Li, Lufeng Yan, Tian Ding, Robert J Linhardt, Yanlei Yu, Xinyue Liu, Donghong Liu, Xingqian Ye, Shiguo Chen
Fucosylated chondroitin sulfates (fCSs) are structurally unusual glycosaminoglycans isolated from sea cucumbers that exhibit potent anticoagulant activity. These fCSs were isolated from sea cucumber, Isostichopus badionotus and Pearsonothuria graeffei. Fenton reaction followed by gel filtration chromatography afforded fCS oligosaccharides, with different sulfation patterns identified by mass and NMR spectroscopy, and these were used to clarify the relationship between the structures and the anticoagulant activities of fCSs...
July 28, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28800452/identification-of-3-4-dihydro-2h-thiochromene-1-1-dioxide-derivatives-with-a-phenoxyethylamine-group-as-highly-potent-and-selective-%C3%AE-1d-adrenoceptor-antagonists
#20
Nobuki Sakauchi, Hideki Furukawa, Junya Shirai, Ayumu Sato, Haruhiko Kuno, Reiko Saikawa, Masato Yoshida
A series of phenoxyethylamine derivatives was designed and synthesized to discover potent and selective human α1D adrenoceptor (α1D adrenergic receptor; α1D-AR) antagonists. Compound 7 was taken from our internal compound collection as an attractive starting point and exhibited moderate binding affinity for α1D-AR and high selectivity against α1A- and α1B-ARs. We focused on modifying the 2-methylsulfonylbenzyl group of 7 to discover novel compounds structurally distinct from other reported α1-AR antagonists containing the phenoxyethylamine motif...
August 1, 2017: European Journal of Medicinal Chemistry
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