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https://www.readbyqxmd.com/read/28812956/toxicity-identification-and-evaluation-for-the-effluent-from-a-nonmetallic-mineral-mining-facility-in-korea-using-d-magna
#1
Sungjong Lee, Hongjoo Ha, JinKyung Hong, Guyoung Kang, Chunsang Hong
Industrial wastewater has attracted increasing attention in recent years because of its impact on ecosystems and human health. Whole-effluent tests are generally used to monitor toxicities of unknown chemicals and conventional pollutants from industrial effluent discharges. This study described identification evaluation (TIE) procedures to determine the acute toxicity of a nonmetallic mineral mining facility effluent that was toxic to Daphnia magna. In the characterization step (TIE phase I), toxic effects of heavy metals, organic compounds, oxidants, volatile organic compounds, suspended solids, and ammonia were screened...
January 1, 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/28805973/experimental-and-clinical-evidence-of-differential-effects-of-magnesium-sulfate-on-neuroprotection-and-angiogenesis-in-the-fetal-brain
#2
Matthieu Lecuyer, Marina Rubio, Clément Chollat, Maryline Lecointre, Sylvie Jégou, Philippe Leroux, Carine Cleren, Isabelle Leroux-Nicollet, Loic Marpeau, Denis Vivien, Stéphane Marret, Bruno J Gonzalez
Clinical studies showed beneficial effects of magnesium sulfate regarding the risk of cerebral palsy. However, regimen protocols fluctuate worldwide and risks of adverse effects impacting the vascular system have been reported for human neonates, keeping open the question of the optimal dosing. Using clinically relevant concentrations and doses of magnesium sulfate, experiments consisted of characterizing, respectively, ex vivo and in vivo, the effects of magnesium sulfate on the nervous and vascular systems of mouse neonates by targeting neuroprotection, angiogenesis, and hemodynamic factors and in measuring, in human fetuses, the impact of a 4-g neuroprotective loading dose of magnesium sulfate on brain hemodynamic parameters...
August 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28803648/automated-multi-filtration-cleanup-with-nitrogen-enriched-activated-carbon-material-as-pesticide-multi-residue-analysis-method-in-representative-crop-commodities
#3
Yuhong Qin, Jingru Zhang, Yifan Li, Qiuxiao Wang, Yangliu Wu, Lanshu Xu, Xiaojuan Jin, Canping Pan
An automated multi-filtration cleanup (Auto m-FC) method with nitrogen-enriched activated carbon material based on modified QuEChERS (quick, easy, cheap, effective, rugged, and safe) extracts was developed. It was applied to pesticide multi-residue analysis in six representative crop commodities. The automatic device was aimed to improve the cleanup efficiency and reduce manual operation workload in cleanup step. By controlling extracts volume, flow rate and Auto m-FC cycles, the device could finish cleanup process accurately...
August 5, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28797894/neuraxial-magnesium-sulfate-improves-postoperative-analgesia-in-cesarean-section-delivery-women-a-meta-analysis-of-randomized-controlled-trials
#4
Shih-Ching Wang, Po-Ting Pan, Hsiao-Yean Chiu, Chun-Jen Huang
BACKGROUND: We conducted this meta-analysis to elucidate whether additional neuraxial magnesium sulfate (MgSO4) can improve postoperative analgesia in women undergoing Cesarean section (CS) delivery. METHOD: We searched Pubmed, Embase and ClinicalTrial.gov. We included only randomized controlled trials that have compared the quality of postoperative analgesia with and without additional neuraxial MgSO4 in women undergoing CS delivery with neuraxial anesthesia regimens...
July 29, 2017: Asian J Anesthesiol
https://www.readbyqxmd.com/read/28793357/preeclampsia
#5
José Geraldo Lopes Ramos, Nelson Sass, Sérgio Hofmeister Martins Costa
The authors review hypertensive disease during pregnancy with an academic and practical view, and using the best evidence available. This disease, which is the most important clinical disease in Brazilian pregnant women, may have its incidence reduced with prevention through the use of calcium and aspirin in pregnant women at risk. Previously, it was a disease that presented with hypertension with proteinuria, but it has now been classified with new clinical parameters besides proteinuria. Morbidity and mortality should be reduced in a continental country such as Brazil using protocols for the early treatment of complications by calculating severe outcomes in preeclampsia...
August 9, 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28772226/liquid-chromatography-tandem-mass-spectrometric-assay-for-the-quantitative-determination-of-the-tyrosine-kinase-inhibitor-quizartinib-in-mouse-plasma-using-salting-out-liquid-liquid-extraction
#6
Irene A Retmana, Jing Wang, Alfred H Schinkel, Jan H M Schellens, Jos H Beijnen, Rolf W Sparidans
A bioanalytical assay for quizartinib -a potent, and selective FLT3 tyrosine kinase inhibitor- in mouse plasma was developed and validated. Salting-out assisted liquid-liquid extraction (SALLE), using acetonitrile and magnesium sulfate, was selected as sample pretreatment with deuterated quizartinib as internal standard. Separation was performed with reversed-phase liquid chromatography followed by detection with positive electrospray-triple quadrupole mass spectrometry in the selected reaction monitoring mode...
July 23, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28771408/promoting-early-child-development-with-interventions-in-health-and-nutrition-a-systematic-review
#7
REVIEW
Tyler Vaivada, Michelle F Gaffey, Zulfiqar A Bhutta
CONTEXT: Although effective health and nutrition interventions for reducing child mortality and morbidity exist, direct evidence of effects on cognitive, motor, and psychosocial development is lacking. OBJECTIVE: To review existing evidence for health and nutrition interventions affecting direct measures of (and pathways to) early child development. DATA SOURCES: Reviews and recent overviews of interventions across the continuum of care and component studies...
August 2017: Pediatrics
https://www.readbyqxmd.com/read/28758749/solvent-shared-ion-pairs-at-the-air-solution-interface-of-magnesium-chloride-and-sulfate-solutions-revealed-by-sum-frequency-spectroscopy-and-molecular-dynamics-simulations
#8
Lisa Götte, Krista M Parry, Wei Hua, Dominique Verreault, Heather C Allen, Douglas J Tobias
The ion distribution and ion pairing properties of Mg(2+), SO4(2-), NO3(-), and Cl(-) in the interfacial region of MgSO4, Mg(NO3)2, and MgCl2 solutions were investigated using vibrational sum frequency generation (VSFG) spectroscopy and molecular dynamics (MD) simulations. An electric field reversal relative to Mg(NO3)2 and MgCl2 solutions is observed at the interface of a MgSO4 solution. We show that, although magnesium cations are expected to have preference for bulk solvation, solvent-shared ion pairs (SIPs) exist in the interfacial region in which Mg(2+) cations are closer to the solution surface than sulfate anions...
August 16, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28757921/the-impact-of-magnesium-sulfate-as-adjuvant-to-intrathecal-bupivacaine-on-intra-operative-surgeon-satisfaction-and-postoperative-analgesia-during-laparoscopic-gynecological-surgery-randomized-clinical-study
#9
Khaled Salah Mohamed, Sayed Kaoud Abd-Elshafy, Ali Mahmoud El Saman
BACKGROUND: Surgeon satisfaction and patient analgesia during the procedure of laparoscopic surgery are important issues. The aim of this work was to study if an intrathecal (IT) Bupivacaine combined with Magnesium sulfate may or may not provide good surgeon satisfaction in addition to improvement of intraoperative and postoperative analgesia. METHODS: Sixty female patients were enrolled in this prospective, randomized, double-blind controlled clinical trial study...
July 2017: Korean Journal of Pain
https://www.readbyqxmd.com/read/28757917/intravenous-caffeine-citrate-vs-magnesium-sulfate-for-reducing-pain-in-patients-with-acute-migraine-headache-a-prospective-quasi-experimental-study
#10
Alireza Baratloo, Sahar Mirbaha, Hossein Delavar Kasmaei, Pooya Payandemehr, Ahmed Elmaraezy, Ahmed Negida
BACKGROUND: Current evidence suggests that intravenous magnesium sulfate might be effective for reducing migraine pain. In a recent pilot study, we showed that intravenous caffeine citrate could reduce the severity of migraine headache. The objective of this study is to investigate the efficacy of intravenous caffeine citrate vs. magnesium sulfate for management of acute migraine headache. METHODS: We conducted a prospective quasi-experimental study from January until May 2016 in two educational medical centers of Shahid Beheshti University of Medical Sciences (Shoahadaye Tajrish Hospital and Imam Hossein Hospital), Tehran, Iran...
July 2017: Korean Journal of Pain
https://www.readbyqxmd.com/read/28755998/loperamide-induced-torsades-de-pointes-a-case-series
#11
Kenneth D Katz, Robert D Cannon, Matthew D Cook, Alexandra Amaducci, Ryan Day, Joshua Enyart, Glenn Burket, Lauren Porter, Timothy Roach, Jennifer Janssen, Karl E Williams
Loperamide is an over-the-counter, inexpensive, antidiarrheal opioid that can produce life-threatening toxicity at high concentrations. CASE REPORT 1: A 28-year-old man with a history of depression and substance abuse disorder (SUD) presented to the emergency department (ED) with shortness of breath and lightheadedness. He ingested large amounts of loperamide daily. The patient's initial electrocardiogram (ECG) demonstrated sinus rhythm, right axis deviation, undetectable PR interval, QRS 168 ms, and QTc 693 ms...
July 26, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28754601/magnesium-sulfate-infusion-for-acute-asthma-in-the-emergency-department
#12
REVIEW
Jose Enrique Irazuzta, Nicolas Chiriboga
OBJECTIVES: To describe the role of intravenous magnesium sulfate (MgSO4) as therapy for acute severe asthma in the pediatric emergency department (ED). SOURCE: Publications were searched in the PubMed and Cochrane databases using the following keywords: magnesium AND asthma AND children AND clinical trial. A total of 53 publications were retrieved using this criteria. References of relevant articles were also screened. The authors included the summary of relevant publications where intravenous magnesium sulfate was studied in children (age <18 years) with acute asthma...
July 26, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28754288/involvement-of-nmda-receptors-in-the-antidepressant-like-effect-of-tramadol-in-the-mouse-forced-swimming-test
#13
Sattar Ostadhadi, Abbas Norouzi-Javidan, Mohsen Chamanara, Reyhaneh Akbarian, Muhammad Imran-Khan, Mehdi Ghasemi, Ahmad-Reza Dehpour
Tramadol is an analgesic agent that is mainly used to treat moderate to severe pain. There is evidence that tramadol may have antidepressant property. However, the mechanisms underlying the antidepressant effects of tramadol have not been elucidated yet. Considering that fact that N-methyl-d-aspartate (NMDA) receptor signaling may play an important role in the pathophysiology of depression, the aim of the present study was to investigate the role of NMDA receptor signaling in the possible antidepressant-like effects of tramadol in the mouse forced swimming test (mFST)...
July 25, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28738788/magnesium-sulfate-for-6-vs-24-hours-post-delivery-in-patients-who-received-magnesium-sulfate-for-less-than-8-hours-before-birth-a-randomized-clinical-trial
#14
Paulino Vigil-De Gracia, Ricardo Ramirez, Yarelys Durán, Arelis Quintero
BACKGROUND: To compare the benefits of magnesium sulfate for 24 h (h) postpartum versus 6 h postpartum in patients who received magnesium sulfate (Mg) for less than 8 h before birth. METHODS: A randomized, multicenter, open study was conducted between November 2013 and October 2016 in three teaching maternity hospitals in Panama. Pregnant women diagnosed with severe pre-eclampsia or pre-eclampsia with severe features at more than 20 weeks gestation were invited to participate...
July 24, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28703019/effectiveness-and-safety-of-magnesium-replacement-in-critically-ill-patients-admitted-to-the-medical-intensive-care-unit-in-an-academic-medical-center-a-retrospective-cohort-study
#15
Drayton A Hammond, Jelena Stojakovic, Niranjan Kathe, Julie Tran, Oktawia A Clem, Kristina Erbach, Jarrod King
BACKGROUND: "Rules of thumb" for the replacement of electrolytes, including magnesium, in critical care settings are used, despite minimal empirical validation of their ability to achieve a target serum concentration. This study's purpose was to evaluate the effectiveness and safety surrounding magnesium replacement in medically, critically ill patients with mild-to-moderate hypomagnesemia. METHODS: This was a single-center, retrospective, observational evaluation of episodes of intravenous magnesium replacement ordered for patients with mild-to-moderate hypomagnesemia (1...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28694751/the-role-of-magnesium-sulfate-in-the-intensive-care-unit
#16
REVIEW
Yunes Panahi, Mojtaba Mojtahedzadeh, Atabak Najafi, Mohammad Reza Ghaini, Mohammad Abdollahi, Mohammad Sharifzadeh, Arezoo Ahmadi, Seyyed Mahdi Rajaee, Amirhossein Sahebkar
Magnesium (Mg) has been developed as a drug with various clinical uses. Mg is a key cation in physiological processes, and the homeostasis of this cation is crucial for the normal function of body organs. Magnesium sulfate (MgSO4) is a mineral pharmaceutical preparation of magnesium that is used as a neuroprotective agent. One rationale for the frequent use of MgSO4 in critical care is the high incidence of hypomagnesaemia in intensive care unit (ICU) patients. Correction of hypomagnesaemia along with the neuroprotective properties of MgSO4 has generated a wide application for MgSO4 in ICU...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28692891/degradation-studies-of-quizalofop-p-and-related-compounds-in-soils-using-liquid-chromatography-coupled-to-low-and-high-resolution-mass-analyzers
#17
Rosalía López-Ruiz, Roberto Romero-González, José Luis Martínez Vidal, Manuel Fernández-Pérez, Antonia Garrido Frenich
A comprehensive degradation study of quizalofop-p, quizalofop-p-ethyl, quizalofop-p-tefuryl and propaquizafop in soil samples have been firstly performed using ultra high performance liquid chromatography coupled to Orbitrap mass spectrometry (UHPLC-Orbitrap-MS). Thus, metabolites or degradation products, such as CHHQ (dihydroxychloroquinoxalin), CHQ (6-chloroquinoxalin-2-ol), PPA ((R)-2-(4-hydroxyphenoxy)propionic acid) and 2,3-dihydroxyquinoxaline were also monitored. An extraction procedure based on QuEChERS procedure was used...
July 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28691718/additive-and-antagonistic-antinociceptive-interactions-between-magnesium-sulfate-and-ketamine-in-the-rat-formalin-test
#18
Katarina Savić Vujović, Sonja Vučković, Dolika Vasović, Branislava Medić, Nick Knežević, Milica Prostran
Because ketamine and magnesium block NMDA receptor activation by distinct mechanisms of action, we hypothesized that in a model of inflammatory pain in rats the combination of ketamine and magnesium might be more effective than ketamine alone. Antinociceptive activity was assessed by the formalin test in male Wistar rats (200-250 g). Animals were injected with 100 μL of 2.5% formalin to the plantar surface of the right hind paw. Data were recorded as the total time spent in pain-related behavior after the injection of formalin or vehicle (0...
2017: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/28690887/prevention-of-%C3%AE-radiation-induced-dna-damage-in-human-lymphocytes-using-a-serine-magnesium-sulfate-mixture
#19
Vahid Changizi, Mona Bahrami, Mahbod Esfahani, Seyed V Shetab-Boushehri
OBJECTIVES: Ionising radiation has deleterious effects on human cells. N-acetylcysteine (NAC) and cysteine, the active metabolite of NAC, are well-known radioprotective agents. Recently, a serine-magnesium sulfate combination was proposed as an antidote for organophosphate toxicity. This study aimed to investigate the use of a serine-magnesium sulfate mixture in the prevention of γ-radiation-induced DNA damage in human lymphocytes as compared to NAC and cysteine. METHODS: This study was carried out at the Iran University of Medical Sciences, Tehran, Iran, between April and September 2016...
May 2017: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/28690617/transcriptomic-analysis-of-soil-grown-t-aestivum-cv-root-to-reveal-the-changes-in-expression-of-genes-in-response-to-multiple-nutrients-deficiency
#20
Saurabh Gupta, Brijesh S Yadav, Utkarsh Raj, Shiri Freilich, Pritish K Varadwaj
Deficiency of necessary macronutrients, i.e., Potassium (K), Magnesium (Mg), Nitrogen (N), Phosphorus (P), and Sulfate (S) in the soil leads to a reduction in plant growth and yield, which is a result of changes in expression level of various genes. This study was performed to identify the differentially expressed genes and its associated metabolic pathways occurred in soil grown wheat root samples excavated from the control and treated fields. To identify the difference in gene expression levels due to deficiency of the said nutrients, a transcriptomic, meta-analysis was performed on array expression profile data...
2017: Frontiers in Plant Science
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