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Kimberly Garner, Kristin Wheeler Chaffee
No abstract text is available yet for this article.
July 2016: Journal of the Arkansas Medical Society
Juhi Bagaitkar, Emilia A Barbu, Lizet J Perez-Zapata, Anthony Austin, Guangming Huang, Sabine Pallat, Mary C Dinauer
Mutations in the leukocyte NADPH oxidase that abrogate superoxide production result in chronic granulomatous disease (CGD), an inherited immunodeficiency associated with recurrent infections and inflammatory complications. The cytosolic regulatory subunit p40(phox) plays a specialized role in stimulating NADPH oxidase activity on intracellular membranes via its phosphatidylinositol 3-phosphate [PI(3)P]-binding domain, as revealed by studies largely focused on neutrophils. Whether PI(3)P-p40(phox)-regulated superoxide production contributes to regulating inflammatory responses is not well understood...
August 19, 2016: Journal of Leukocyte Biology
Juhi Bagaitkar, Nancy K Pech, Stoyan Ivanov, Anthony Austin, Melody Yue Zeng, Sabine Pallat, Guangming Huang, Gwendalyn J Randolph, Mary C Dinauer
The leukocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase generates reactive oxygen species essential in microbial killing and regulation of inflammation. Inactivating mutations in this enzyme lead to chronic granulomatous disease (CGD), associated with increased susceptibility to both pyogenic infections and to inflammatory disorders. The role of the NADPH oxidase in regulating inflammation driven by nonmicrobial stimuli is poorly understood. Here, we show that NADPH oxidase deficiency enhances the early local release of interleukin-1α (IL-1α) in response to damaged cells, promoting an excessive granulocyte colony-stimulating factor (G-CSF)-regulated neutrophilic response and prolonged inflammation...
December 17, 2015: Blood
Paul M Arnstein
No abstract text is available yet for this article.
September 2015: Journal of Pain & Palliative Care Pharmacotherapy
Sharon Borik, Christopher K Macgowan, Mike Seed
Using phase-contrast MRI in a foetus with borderline left ventricular hypoplasia at 37 weeks' gestation we showed an increase in pulmonary blood flow during maternal hyperoxygenation. The associated increase in venous return to the left atrium, however, resulted in reversal of the atrial shunt, with no improvement in left ventricular output. The child initially underwent single ventricle palliation with a neonatal hybrid procedure, but following postnatal growth of the left ventricle tolerated conversion to a biventricular circulation at 5 months of age...
August 2015: Cardiology in the Young
Margaret Butko, Hilary Pallat, Armando Cordoba, X Christopher Yu
Recombinant antibodies produced in Chinese hamster ovary (CHO) cells often exhibit a slight yellow-brown color, but the molecular basis for this color has remained elusive. We predicted that the color results from post-translational modifications on the antibody, because colored species were found to coelute with antibody products during size exclusion chromatography. Previously, modification by oxidation and advanced glycation end products (AGEs) had been shown to give rise to colored and fluorescent species whose spectral properties are in agreement with the spectral properties of CHO-derived recombinant antibodies...
October 7, 2014: Analytical Chemistry
Hui Xu, Song-Hua Xiao, Zheng-Sheng Liu, Zheng Wang, Xue-Song Zhang, Niag Lu, Yong-Fei Zhao, Yan Wang
OBJECTIVE: To evaluate surgical strategy and clinical outcomes for the treatment of thoracolumbar metastatic tumor. METHODS: From January 2009 to December 2010,42 patients with thoracolumbar metastatic tumor were treated surgically. Among the patients, 30 patients were male, and 12 patients were female, ranging in age from 28 to 76 years old, with an average age of 56.8 years old. Twenty-five patients had metastatic tumor in thoracic vertebraes, and 17 patients had metastatic tumor in lumbar vertebraes...
January 2014: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Hermann S Füessl
No abstract text is available yet for this article.
April 5, 2012: MMW Fortschritte der Medizin
M K Bendiane, A-D Bouhnik, A Galinier, R Favre, Y Obadia, P Peretti-Watel
BACKGROUND: Hospital nurses are frequently the first care givers to receive a patient's request for euthanasia or physician-assisted suicide (PAS). In France, there is no consensus over which medical practices should be considered euthanasia, and this lack of consensus blurred the debate about euthanasia and PAS legalisation. This study aimed to investigate French hospital nurses' opinions towards both legalisations, including personal conceptions of euthanasia and working conditions and organisation...
April 2009: Journal of Medical Ethics
Tomasz Bielecki, Tadeusz Szymon Gaździk, Andrzej Jurkiewicz
Background. The most common complication of bone metastases to the hip is pathological fracture of the proximal epiphysis. The present study presents the indications and contraindications for surgery and the choice of particular surgical techniques, based on the literature and the authors' own experience. <br /> Material and methods. In the period 1992-2002 we treated 25 patients with bone metastases to the proximal epiphysis of the femur. All had suffered pathological fractures. Various surgical procedures were used, depending on the indications...
June 30, 2003: Ortopedia, Traumatologia, Rehabilitacja
Marilena Montesano, Pierfilippo Crucitti, Monica Pandolfi, Annie Zanca, Armando Gabbrielli, Roberto Coppola
Esophagorespiratory fistulas, especially in the upper third of the esophagus, are a complication of malignant esophageal tumors, whose management is difficult and prognosis is poor. Treatment is palliative and involves restoration of the ability to ingest food and prevention of aspiration by insertion of esophageal or tracheobronchial stents. In selected patients the insertion of a single stent may be insufficient for pallation therefore the placement of parallel stents may be indicated in patients with symptoms caused by malignant esophagorespiratory fistula...
January 2006: Rays
Phillip D Good, John D Cavenagh, David C Currow, David A Woods, Penelope H Tuffin, Peter J Ravenscroft
BACKGROUND: There is a disparity of availability and cost of drugs in the community for palliative care patients through the Pharmaceutical Benefits Scheme (PBS) compared to those available to inpatients in public hospitals. METHODS: The Joint Therapeutics Committee of the Australian and New Zealand Society of Palliative Medicine, Palliative Care Australia and the Clinical Oncological Society of Australia surveyed palliative care practitioners in Australia to compile a list of drugs they considered essential...
April 2006: Australian Family Physician
No abstract text is available yet for this article.
March 1953: American Surgeon
Charles F Von Gunten, Patricia B Mullan, Shawn Harrity, Joel Diamant, Edwin Heffernan, Tyson Ikeda, William L Roberts et al.
BACKGROUND: The faculty of the Center for Palliative Studies teach residents from 5 different primary care residency training programs who rotate at San Diego Hospice: 3 in Internal Medicine, 2 in Family Medicine. Residents participate in the care of patients in the inpatient care setting and make joint home visits with physicians and other team members. A series of 4 lectures on end-of-life care is given on Tuesday mornings: management of pain, other symptoms, interdisciplinary roles of chaplains, social workers, nurses, and grief/bereavement are discussed...
2003: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
H Cüneyt Ulutin, Cengiz Beyan, Yücel Pak
Mycosis fungoides is the most common form of cutaneous T-cell lymphoma. In our department, between January 1995 to January 2001, we treated eleven patients with mycosis fungoides by total body skin electron irradiation to evaluate its influence. According to our knowledge, our department is the only center in Turkey capable of applying total skin electron beam therapy. Total skin electron beam therapy was applied by using the "translational technique". Daily doses (4 Gray) were given in a total of seven fractions according to the conventional fractionation scheme...
2002: Haematologia
R Jakobs, M Maier, C Benz, W R Martin, H E Adamek, J F Riemann
PROBLEM AND OBJECTIVE: In the last few years several intra- and extracorporeal endoscopic methods have been developed for treating intrahepatic gallstones, but as yet no ideal instrumentation has been found. This study was undertaken to test the efficacy and possible complications of intracorporeal laser lithotripsy for intrahepatic gallstones. PATIENTS AND METHODS: 16 consecutive patients were included (13 women and 3 men, median age 64 [28-82] years) with intrahepatic biliary tract stones which could not be removed by conventional endoscopy...
March 14, 1997: Deutsche Medizinische Wochenschrift
W Garnjobst
When pallative cholecystoenterostomy is contemplated but the cystic duct is found to be occluded, anastomosis of the hepatic duct to the gallbladder in combination with cholecystoenterostomy is a satisfactory alternative to decompression of the heptic duct by jejunal anastomosis and may be easier to perform. Hepatocholecystostomy is also useful as a simple operative method for restoring continuity when jaundice recurs after cholecystoenterostomy done for cystic duct obstruction.
September 1982: Archives of Surgery
H Lüdeke
No abstract text is available yet for this article.
July 1968: HNO
S Wilkinson
Communication is one of the most important aspects of cancer nursing. Evidence suggests nurses experience communication difficulties and frequently block patients from divulging their worries or concerns. This paper focuses on a study which aimed to determine: (a) the extent to which nurses facilitate or block patients and awareness of their verbal behaviours; (b) whether there is a relationship between nurses' verbal behaviours and levels of anxiety, social support, work support and attitude to death; and (c) nurses' difficulties in caring for cancer patients...
June 1991: Journal of Advanced Nursing
H H Kimose, O Lund, J M Hasenkam, M T Aagaard, M Erlandsen
During the 25 years 1960-84, 657 patients were operated on for carcinomas of the thoracic oesophagus (n = 347) or gastric cardia (n = 310). Resection was carried out in 514 (78%) and oesophagogastrostomy in 481 (73%). Overall operative mortality (defined as death within 30 days) was 19% (n = 122). Pulmonary complications developed in 167 patients (25%), cardiovascular complications in 100 (15%), and anastomotic leakage and mediastinitis in 36 (6%). After radical resection of a localised tumour (n = 144), or non-localised tumour (n = 224), pallative resection (n = 146), or exploration (n = 143), the operative mortality and five year cumulative survival were 10% and 26%, 15% and 8%, 27% and 0, and 24% and 0, respectively (p less than 0...
May 1990: Acta Chirurgica Scandinavica
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