keyword
https://read.qxmd.com/read/38516000/kr%C3%A3-pple-like-factors-in-cardiomyopathy-emerging-player-and-therapeutic-opportunities
#21
REVIEW
Le-Kun Gui, Huang-Jun Liu, Li-Jun Jin, Xiao-Chun Peng
Cardiomyopathy, a heterogeneous pathological condition characterized by changes in cardiac structure or function, represents a significant risk factor for the prevalence and mortality of cardiovascular disease (CVD). Research conducted over the years has led to the modification of definition and classification of cardiomyopathy. Herein, we reviewed seven of the most common types of cardiomyopathies, including Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC), diabetic cardiomyopathy, Dilated Cardiomyopathy (DCM), desmin-associated cardiomyopathy, Hypertrophic Cardiomyopathy (HCM), Ischemic Cardiomyopathy (ICM), and obesity cardiomyopathy, focusing on their definitions, epidemiology, and influencing factors...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38515760/crosstalk-between-ubiquitin-ligases-and-ncrnas-drives-cardiovascular-disease-progression
#22
REVIEW
Jia-Rui You, Zeng-Jin Wen, Jia-Wei Tian, Xiao-Bing Lv, Rong Li, Shu-Ping Li, Hui Xin, Pei-Feng Li, Yin-Feng Zhang, Rui Zhang
Cardiovascular diseases (CVDs) are multifactorial chronic diseases and have the highest rates of morbidity and mortality worldwide. The ubiquitin-proteasome system (UPS) plays a crucial role in posttranslational modification and quality control of proteins, maintaining intracellular homeostasis via degradation of misfolded, short-lived, or nonfunctional regulatory proteins. Noncoding RNAs (ncRNAs, such as microRNAs, long noncoding RNAs, circular RNAs and small interfering RNAs) serve as epigenetic factors and directly or indirectly participate in various physiological and pathological processes...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38513361/non-hdl-cholesterol-and-residual-cardiovascular-risk-in-statin-treated-patients-with-and-without-diabetes-the-western-denmark-heart-registry
#23
JOURNAL ARTICLE
Malene Kærslund Hansen, Martin Bødtker Mortensen, Kevin Kris Warnakula Olesen, Pernille Gro Thrane, Reimar Wernich Thomsen, Michael Maeng
AIMS: Assessment of residual cardiovascular risk in statin-treated patients with atherosclerotic cardiovascular disease (ASCVD) is pivotal for optimising secondary preventive therapies. This study investigates if non-high-density lipoprotein cholesterol (non-HDL-C) is associated with residual ASCVD risk in statin-treated ischemic heart disease (IHD) patients with and without diabetes. METHODS: Using the Western Denmark Heart Registry, we identified statin-treated patients with IHD examined by coronary angiography (CAG) from 2011-2020...
March 21, 2024: European Journal of Preventive Cardiology
https://read.qxmd.com/read/38512255/long-term-body-mass-index-variability-and-adverse-cardiovascular-outcomes
#24
JOURNAL ARTICLE
Zakaria Almuwaqqat, Qin Hui, Chang Liu, Jin J Zhou, Benjamin F Voight, Yuk-Lam Ho, Daniel C Posner, Jason L Vassy, J Michael Gaziano, Kelly Cho, Peter W F Wilson, Yan V Sun
IMPORTANCE: Body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) is a commonly used estimate of obesity, which is a complex trait affected by genetic and lifestyle factors. Marked weight gain and loss could be associated with adverse biological processes. OBJECTIVE: To evaluate the association between BMI variability and incident cardiovascular disease (CVD) events in 2 distinct cohorts. DESIGN, SETTING, AND PARTICIPANTS: This cohort study used data from the Million Veteran Program (MVP) between 2011 and 2018 and participants in the UK Biobank (UKB) enrolled between 2006 and 2010...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38511179/sex-specific-disparities-in-patients-undergoing-isolated-cabg
#25
JOURNAL ARTICLE
Maya T Dassanayake, Elizabeth L Norton, Alison F Ward, Nanette K Wenger
STUDY OBJECTIVE: Examine sex-specific characteristics in patients undergoing coronary artery bypass grafting (CABG) at our institution. DESIGN: Retrospective chart review was performed utilizing our institutional Society of Thoracic Surgeons (STS) database. SETTING: An academic, quaternary care center from 2010 to 2021. PARTICIPANTS: 3163 females and 9573 males underwent isolated CABG. INTERVENTIONS: The institutional STS database was queried for preoperative, intraoperative, and postoperative variables...
November 2023: American heart journal plus: cardiology research and practice
https://read.qxmd.com/read/38510556/nt-probnp-in-patients-presenting-with-myocardial-infarction-and-non-obstructive-coronary-arteries-without-left-ventricular-systolic-dysfunction
#26
JOURNAL ARTICLE
Robert Sykes, Daniel Doherty, Andrew Morrow, Kenneth Mangion, Ahsan Rushd, Colin Berry
BACKGROUND: Myocardial infarction and non-obstructive coronary arteries (MINOCA) affects 1 in 9 patients with acute coronary syndrome and has no evidence-based therapy. NT-proBNP is an established biomarker associated with prognosis in heart failure and ischemic heart disease, although there is a paucity of data in patients with MINOCA. METHODS: Prospective study of the diagnostic and clinical utility of measuring NT-proBNP in patients with MINOCA without left ventricular dysfunction or heart failure...
September 2023: American heart journal plus: cardiology research and practice
https://read.qxmd.com/read/38510502/elevated-high-density-lipoprotein-cholesterol-and-adverse-outcomes-in-women-with-symptoms-of-ischemic-heart-disease
#27
JOURNAL ARTICLE
Sachini Ranasinghe, Yujie Cui, Amer Muhyieddeen, Okezi Obrutu, Janet Wei, Martha Gulati, Vera Bittner, Steven Reis, Eileen Handberg, Carl J Pepine, C Noel Bairey Merz
BACKGROUND: Emerging data in the general population and those with coronary artery disease demonstrate higher risk of adverse outcomes with high (>70 mg/dL) HDL-C levels. There are limited data on the risk of adverse outcomes in women with suspected ischemic heart disease. OBJECTIVE: To investigate relationships between high (>70 mg/dL), average (50-70 mg/dL), and low (<50 mg/dL) HDL-C levels with major adverse cardiac events (MACE) (death, myocardial infarction, stroke, and heart failure hospitalization), and all-cause mortality in women referred for coronary angiography for suspected myocardial ischemia...
April 2024: American heart journal plus: cardiology research and practice
https://read.qxmd.com/read/38506414/low-intensity-statin-plus-ezetimibe-versus-moderate-intensity-statin-for-primary-prevention-a-population-based-retrospective-cohort-study-in-asian-population
#28
JOURNAL ARTICLE
Minji Jung, Beom-Jin Lee, Sukhyang Lee, Jaekyu Shin
BACKGROUND: While moderate-intensity statin therapy is recommended for primary prevention, statins may not be utilized at a recommended intensity due to dose-dependent adverse events, especially in an Asian population. However, evidence supporting the use of low-intensity statins in primary prevention is limited. OBJECTIVE: We sought to compare clinical outcomes between a low-intensity statin plus ezetimibe and a moderate-intensity statin for primary prevention...
March 20, 2024: Annals of Pharmacotherapy
https://read.qxmd.com/read/38505015/myocardial-protection-comparing-histological-effects-of-single-dose-cardioplegic-solutions-study-protocol-for-a-secondary-analysis-of-the-cardioplegia-trial
#29
JOURNAL ARTICLE
Kathize Betti Lira, Renan Senandes Delvaux, Felipe Abatti Spadini, Luis Henrique Hauschild, Rafael Oliveira Ceron, Fernando Anschau, Luciane Kopittke, Juarez Rode, Rafael Antônio Widholzer Rey, Estefania Inez Wittke, Alfeu Roberto Rombaldi, Eduardo Cambruzzi, Eron Rodrigues Cunha Lopes, Adriana Silveira Almeida
BACKGROUND: Myocardial protection is crucial for successful cardiac surgery, as it prevents heart muscle damage that can occur during the procedure. Prolonged hypoxia without proper protection can lead to adenosine triphosphate consumption, microvilli loss, blister formation, and edema. Custodiol, del Nido, and modified del Nido are single-dose cardioplegic solutions with proven safety and significance in modern surgery. While each has been independently assessed for patient outcomes, limited research directly compares them...
February 29, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38504228/ischemic-heart-disease-related-mortality-in-brazil-2006-to-2020-a-study-of-multiple-causes-of-death
#30
JOURNAL ARTICLE
Luiz A V M Bastos, Paolo B Villela, Jose L P Bichara, Emilia M do Nascimento, Eduardo L V M Bastos, Basilio de B Pereira, Glaucia M M Oliveira
CONTEXT: Both the aging of the population and the increase in noncommunicable diseases may influence the progression and outcomes culminating in death, changing the evolution of ischemic heart diseases (IHDs) and their associated causes. Using the multiple causes of death method could help understand the magnitude of these relationships and enable better targeting of investments in health. OBJECTIVES: To evaluate the mortality from IHD in Brazil between 2006 and 2020 using the method of multiple causes and identify differences in the distribution pattern of IHD mortality by sex and geographic region...
March 19, 2024: BMC Public Health
https://read.qxmd.com/read/38503934/mir-181a-protects-the-heart-against-myocardial-infarction-by-regulating-mitochondrial-fission-via-targeting-programmed-cell-death-protein-4
#31
JOURNAL ARTICLE
Jianbing Zhu, Qian Wang, Zeqi Zheng, Leilei Ma, Junjie Guo, Hongtao Shi, Ru Ying, Beilei Gao, Shanshan Chen, Siyang Yu, Bin Yuan, Xiaoping Peng, Junbo Ge
Worldwide, myocardial infarction (MI) is the leading cause of death and disability-adjusted life years lost. Recent researches explored new methods of detecting biomarkers that can predict the risk of developing myocardial infarction, which includes identifying genetic markers associated with increased risk. We induced myocardial infarction in mice by occluding the left anterior descending coronary artery and performed TTC staining to assess cell death. Next, we performed ChIP assays to measure the enrichment of histone modifications at the promoter regions of key genes involved in mitochondrial fission...
March 19, 2024: Scientific Reports
https://read.qxmd.com/read/38503643/utility-of-coronary-revascularization-in-patients-with-ischemic-left-ventricular-dysfunction
#32
REVIEW
Mohammed Al-Sadawi, Michael Tao, Simrat Dhaliwal, Archanna Radakrishnan, Yang Liu, Chad Gier, Ravi Masson, Tahmid Rahman, Edlira Tam, Noelle Mann
BACKGROUND: Revascularization in patients with left ventricular (LV) dysfunction has been a subject of ongoing uncertainty and conflicting results. This is further complicated by factors including viability, severity of LV dysfunction, and method of revascularization using percutaneous coronary intervention (PCI) versus coronary-artery bypass grafting (CABG). OBJECTIVES: The purpose of this meta-analysis is to evaluate the association of coronary revascularization with outcomes in patients with ischemic LV dysfunction...
March 5, 2024: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://read.qxmd.com/read/38502888/early-vs-delayed-mechanical-circulatory-support-in-patients-with-acute-myocardial-infarction-and-cardiogenic-shock
#33
JOURNAL ARTICLE
Kevin G Buda, Katarzyna Hryniewicz, Peter M Eckman, Mir B Basir, Jennifer A Cowger, Khaldoon Alaswad, Srini Mukundan, Yader Sandoval, Andrea Elliott, Emmanouil S Brilakis, Michael S Megaly
BACKGROUND: Despite increased temporary mechanical circulatory support (tMCS) utilization for acute myocardial infarction complicated by cardiogenic shock (AMI-CS), data regarding efficacy and optimal timing for tMCS support are limited. This study aimed to describe outcomes based on tMCS timing in AMI-CS and to identify predictors of 30-day mortality and readmission. METHODS: Patients with AMI-CS identified in the National Readmissions Database were grouped according to the use of tMCS and early (<24 hours) vs...
March 19, 2024: European Heart Journal. Acute Cardiovascular Care
https://read.qxmd.com/read/38500756/role-of-low-density-lipoprotein-electronegativity-and-sexual-dimorphism-in-contributing-early-ventricular-tachyarrhythmias-following-st-elevation-myocardial-infarction
#34
JOURNAL ARTICLE
Mei-Yao Wu, An-Sheng Lee, Yen-Nien Lin, Wei-Hsin Chung, Ke-Wei Chen, Chiung-Ray Lu, Yun-Fang Chen, Chia-Ming Chang, Wei-Chung Tsai, Yi-Tzone Shiao, Chu-Huang Chen, Kuan-Cheng Chang
BACKGROUND: Early ventricular tachycardia/fibrillation (VT/VF) in patients with ST-elevation myocardial infarction (STEMI) has higher morbidity and mortality. This study examines gender-differentiated risk factors and underlying mechanisms for early onset VT/VF in STEMI. METHODS: We analyzed data from 2,964 consecutive STEMI patients between January 1, 2008 and December 31, 2021. Early VT/VF was defined as occurrence of spontaneous VT/VF of ≥30 s or requirement of immediate cardioversion/defibrillation within the first 48 h after symptoms...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38500462/pathological-characteristics-and-classification-of-unstable-coronary-atherosclerotic-plaques
#35
JOURNAL ARTICLE
Yun-Hong Xing, Yang Li, Wen-Zheng Wang, Liang-Liang Wang, Le-le Sun, Qiu-Xiang DU, Jie Cao, Guang-Long He, Jun-Hong Sun
Important forensic diagnostic indicators of sudden death in coronary atherosclerotic heart disease, such as acute or chronic myocardial ischemic changes, sometimes make it difficult to locate the ischemic site due to the short death process, the lack of tissue reaction time. In some cases, the deceased died of sudden death on the first-episode, resulting in difficulty for medical examiners to make an accurate diagnosis. However, clinical studies on coronary instability plaque revealed the key role of coronary spasm and thrombosis caused by their lesions in sudden coronary death process...
February 25, 2024: Fa Yi Xue za Zhi
https://read.qxmd.com/read/38495657/spectrum-of-ischemic-heart-disease-throughout-a-woman-s-life-cycle
#36
REVIEW
Smitha Narayana Gowda, Sai Sita Garapati, Karla Kurrelmeyer
Ischemic heart disease (IHD) is the leading cause of morbidity and mortality in both genders; however, young women fare the worst, likely reflecting the more complex spectrum of IHD in women when compared to men. Substantial sex-based differences exist in the underlying risk factors, risk enhancers, presentation, diagnosis, and pathophysiology of IHD that are mainly attributed to the influence of female sex hormones. This article reviews the spectrum of IHD including obstructive epicardial coronary artery disease (CAD), myocardial infarction with no obstructive coronary artery disease, ischemia with no obstructive coronary artery disease, spontaneous coronary artery dissection, coronary microvascular dysfunction, vasospastic angina, and coronary thrombosis/embolism that occur in women throughout various stages of their life cycle...
2024: Methodist DeBakey Cardiovascular Journal
https://read.qxmd.com/read/38493531/sex-disparities-in-cardiogenic-shock-insights-from-the-frenshock-registry
#37
JOURNAL ARTICLE
Stéphane Manzo-Silberman, Anne-Céline Martin, Florence Boissier, Caroline Hauw-Berlemont, Nadia Aissaoui, Nicolas Lamblin, François Roubille, Eric Bonnefoy, Laurent Bonello, Meyer Elbaz, Guillaume Schurtz, Olivier Morel, Guillaume Leurent, Bruno Levy, Bernard Jouve, Brahim Harbaoui, Gérald Vanzetto, Nicolas Combaret, Benoit Lattucca, Sébastien Champion, Pascal Lim, Cédric Bruel, Francis Schneider, Marie-France Seronde, Vincent Bataille, Edouard Gerbaud, Etienne Puymirat, Clément Delmas
BACKGROUND: Cardiogenic shock (CS) is the most severe form of acute heart failure. Discrepancies have been reported between sexes regarding delays, pathways and invasive strategies in CS complicating acute myocardial infarction. However, effect of sex on the prognosis of unselected CS remains controversial. OBJECTIVES: The aim was to analyze the impact of sex on aetiology, management and prognosis of CS. METHODS: The FRENSHOCK registry included all CS admitted in 49 French Intensive Care Units (ICU) and Intensive Cardiac Care Units (ICCU) between April and October 2016...
March 16, 2024: Journal of Critical Care
https://read.qxmd.com/read/38492858/autoimmune-blistering-disorders-and-cardiovascular-risks-a-population-based-cohort-study
#38
JOURNAL ARTICLE
Kasper Bonnesen, Christian F B Poulsen, Sigrun A J Schmidt, Henrik T Sørensen, Morten Schmidt
BACKGROUND: Autoimmune blistering disorders (ABDs) might elevate cardiovascular risk, but studies are lacking. OBJECTIVE: To examine if ABDs elevate the risk of atherosclerotic cardiovascular disease (ASCVD), heart failure, arrhythmia, venous thromboembolism, and cardiovascular death. METHODS: A population-based cohort of Danish patients with ABD (≥18 years of age) diagnosed during 1996-2021 (n=3,322) was compared with an age and sex-matched comparison cohort from the general population (n=33,195)...
March 14, 2024: Journal of the American Academy of Dermatology
https://read.qxmd.com/read/38492720/choice-of-revascularization-strategy-for-ischemic-cardiomyopathy-due-to-multi-vessel-coronary-disease
#39
JOURNAL ARTICLE
Anas H Alzahrani, Shinobu Itagaki, Natalia Egorova, Joanna Chikwe
BACKGROUND: Limited comparative data guide the decision between coronary bypass surgery (CABG) versus percutaneous coronary intervention (PCI) for multivessel revascularization in ischemic cardiomyopathy. OBJECTIVES: To compare long-term outcomes of CABG and PCI for ischemic cardiomyopathy. METHODS: Clinical registries from NJ Department of Health linked to administrative databases were used to compare all-cause mortality, repeat revascularization, heart failure (HF) readmissions, myocardial infarction (MI), and stroke using Cox proportional hazards and propensity matching with competing risk analysis in 5988 patients with ejection fraction ≤35% who underwent CABG (3673,61...
March 14, 2024: Journal of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/38492177/systematic-review-of-literature-citing-the-ischemia-trial
#40
REVIEW
David J King, Christian Eskander, Jacob Ricci, David Gittess, Rushi Patel, Mitchell Bourne, Jeffery Budweg, David E Winchester
PURPOSE OF REVIEW: Optimal therapy for patients with chronic coronary artery disease (CCD) has long been a topic under investigation and a subject of debate. Seeking to clarify appropriate management, the International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) trial compared medical management versus coronary angiography for patients with stable ischemic heart disease. Its reception in the medical community has been met with both acclaim and criticism...
March 16, 2024: Current Cardiology Reports
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