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https://www.readbyqxmd.com/read/28926758/some-aspects-of-the-iodine-metabolism-of-the-giant-kelp-macrocystis-pyrifera-phaeophyceae
#1
Teresa M Tymon, Eric P Miller, Jennifer L Gonzales, Andrea Raab, Frithjof C Küpper, Carl J Carrano
Despite its paramount role in the functioning of coastal ecosystems, relatively little is known about halogen metabolism in giant kelp (Macrocystis pyrifera). This is an important shortcoming given the potential implications for marine and atmospheric chemical processes in the wide distribution range of Macrocystis. The work presented here constitutes the first in depth investigation of the uptake, efflux, and of the physiological function of iodide in this important kelp species. Iodide uptake and efflux rates were measured in adult sporophytes of Macrocystis under normal and stressed (exogenous hydrogen peroxide and an elicitor-triggered oxidative burst) conditions...
September 8, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28926706/structural-and-kinetic-characterization-of-the-intrinsically-disordered-protein-sev-ntail-through-enhanced-sampling-simulations
#2
Mattia Bernetti, Matteo Masetti, Fabio Pietrucci, Martin Blackledge, Malene Ringkjøbing Jensen, Maurizio Recanatini, Luca Mollica, Andrea Cavalli
Intrinsically disordered proteins (IDPs) are emerging as an important class of the proteome. Being able to interact with different molecular targets, they participate in many physiological and pathological activities. However, due to their intrinsically heterogeneous nature, determining the equilibrium properties of IDPs is still a challenge for biophysics. Herein, we applied state-of-the-art enhanced sampling methods to Sev NTAIL, a test case of IDPs, and constructed a bin-based kinetic model to unveil the underlying kinetics...
September 19, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28926613/human-in-the-loop-bayesian-optimization-of-wearable-device-parameters
#3
Myunghee Kim, Ye Ding, Philippe Malcolm, Jozefien Speeckaert, Christoper J Siviy, Conor J Walsh, Scott Kuindersma
The increasing capabilities of exoskeletons and powered prosthetics for walking assistance have paved the way for more sophisticated and individualized control strategies. In response to this opportunity, recent work on human-in-the-loop optimization has considered the problem of automatically tuning control parameters based on realtime physiological measurements. However, the common use of metabolic cost as a performance metric creates significant experimental challenges due to its long measurement times and low signal-to-noise ratio...
2017: PloS One
https://www.readbyqxmd.com/read/28926141/working-at-the-membrane-interface-ligand-induced-changes-in-dynamic-conformation-and-oligomeric-structure-in-human-aromatase
#4
Giovanna Di Nardo, Giuseppe Cimicata, Roberta Baravalle, Valentina Dell'Angelo, Alberto Ciaramella, Gianluca Catucci, Piero Ugliengo, Gianfranco Gilardi
Aromatase catalyses the biosynthesis of estrogens from androgens. Due to the physiological importance of this conversion of lipophilic substrates, the interaction with the lipid bilayer for this cytochrome P450 is crucial for its dynamics that must allow an easy access to substrates and inhibitors. Here, aromatase-anastrozole interaction is studied combining computational methods to identify possible access/egress routes with the protein inserted in the membrane and experimental tools aimed at the investigation of the effect of the inhibitor on the protein conformation...
September 19, 2017: Biotechnology and Applied Biochemistry
https://www.readbyqxmd.com/read/28925331/assessment-of-the-effectiveness-of-modular-clothing-protecting-against-the-cold-based-on-physiological-tests
#5
Anna Marszałek, Grażyna Bartkowiak, Anna Dąbrowska
At many work stations under cold environment, protective clothing, which is provided for the workers is characterized by an inadequate thermal insulation, which results in an adverse impact of cold environment on a worker's body. The purpose of this paper is to present a developed new ergonomic modular cold protective clothing, which allows for easy adaptation of the thermal insulation of clothing to worker's individual needs. This clothing was compared in a laboratory study with the clothing having been used so far by workers of cold environment using physiological and physical measurements, subjective ratings of thermal state as well a questionnaire of subjective assessment of used clothing...
September 19, 2017: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/28923599/-theranostic-role-of-bile-salt-capped-silver-nanoparticles-gall-stone-pigment-stone-disruption-and-anticancer-activity
#6
Ranju Prasad Mandal, Gunjan Mandal, Sudeshna Sarkar, Arindam Bhattacharyya, Swati De
Silver nanoparticles (AgNPs) have been synthesized in situ in micelles formed by the bile salt sodium deoxycholate (NaDC). The AgNPs exhibit "green" fluorescence. It has been shown in the present study that they can disrupt the components of gall stones/pigment stones. This unique ability of the AgNPs has been observed upon detailed study of the interaction between the endobiotic pigment bilirubin (BR) and bile salt (NaDC). In addition, these AgNPs show significant cytotoxicity towards the breast cancer cells (MCF-7)...
September 5, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28923556/de-novo-assembly-and-transcriptome-characterization-of-the-freshwater-prawn-palaemonetes-argentinus-implications-for-a-detoxification-response
#7
C Fernando García, Nicolas Pedrini, Arturo Sánchez-Paz, Carlos S Reyna-Blanco, Sabrina Lavarias, Adriana Muhlia-Almazán, Analía Fernández-Giménez, Aldana Laino, Enrique de-la-Re-Vega, German Lukaszewicz, Alonso A López-Zavala, Luis G Brieba, Michael F Criscitello, Jesús S Carrasco-Miranda, Karina D García-Orozco, Adrian Ochoa-Leyva, Enrique Rudiño-Piñera, Alejandro Sanchez-Flores, Rogerio R Sotelo-Mundo
Palaemonetes argentinus, an abundant freshwater prawn species in the northern and central region of Argentina, has been used as a bioindicator of environmental pollutants as it displays a very high sensitivity to pollutants exposure. Despite their extraordinary ecological relevance, a lack of genomic information has hindered a more thorough understanding of the molecular mechanisms potentially involved in detoxification processes of this species. Thus, transcriptomic profiling studies represent a promising approach to overcome the limitations imposed by the lack of extensive genomic resources for P...
September 8, 2017: Marine Genomics
https://www.readbyqxmd.com/read/28923174/27-hydroxycholesterol-an-endogenous-selective-estrogen-receptor-modulator
#8
REVIEW
Sisi He, Erik R Nelson
Estrogen receptors (ERs) mediate the actions of the steroidal estrogens, and are important for the regulation of several physiological and pathophysiological processes, including reproduction, bone physiology, cardiovascular physiology and breast cancer. The unique pharmacology of the ERs allows for certain ligands, such as tamoxifen, to elicit tissue- and context-specific responses, ligands now referred to as selective estrogen receptor modulators (SERMs). Recently, the cholesterol metabolite 27-hydroxychoelsterol (27HC) has been defined as an endogenous SERM, with activities in atherosclerosis, osteoporosis, breast and prostate cancers, and neural degenerative diseases...
October 2017: Maturitas
https://www.readbyqxmd.com/read/28923140/working-memory-capacity-and-surgical-performance-while-exposed-to-mild-hypoxic-hypoxemia
#9
Paul J Parker, Andrew J Manley, Ross Shand, John P O'Hara, Adrian Mellor
INTRODUCTION: Medical Emergency Response Team (MERT) helicopters fly at altitudes of 3000 m in Afghanistan (9843 ft). Civilian hospitals and disaster-relief surgical teams may have to operate at such altitudes or even higher. Mild hypoxia has been seen to affect the performance of novel tasks at flight levels as low as 5000 ft. Aeromedical teams frequently work in unpressurized environments; it is important to understand the implications of this mild hypoxia and investigate whether supplementary oxygen systems are required for some or all of the team members...
October 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28922753/effects-of-periodic-photoinhibitory-light-exposure-on-physiology-and-productivity-of-arabidopsis-plants-grown-under-low-light
#10
Yonglan Tian, Joanna Sacharz, Maxwell A Ware, Huayong Zhang, Alexander V Ruban
This work examined the long-term effects of periodic high light stress on photosynthesis, morphology, and productivity of low-light-acclimated Arabidopsis plants. Significant photoinhibition of Arabidopsis seedlings grown under low light (100 μmol photons m-2 s-1) was observed at the beginning of the high light treatment (three times a day for 30 min at 1800 μmol photons m-2 s-1). However, after 2 weeks of treatment, similar photosynthesis yields (Fv/Fm) to those of control plants were attained. The daily levels of photochemical quenching measured in the dark (qPd) indicated that the plants recovered from photoinhibition within several hours once transferred back to low light conditions, with complete recovery being achieved overnight...
July 10, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28922650/constitutive-modeling-of-the-passive-inflation-extension-behavior-of-the-swine-colon
#11
Bhavesh Patel, Huan Chen, Aashish Ahuja, Joshua F Krieger, Jillian Noblet, Sean Chambers, Ghassan S Kassab
In the present work, we propose the first structural constitutive model of the passive mechanical behavior of the swine colon that is validated against physiological inflation-extension tests, and accounts for residual strains. Sections from the spiral colon and the descending colon were considered to investigate potential regional variability. We found that the proposed constitutive model accurately captures the passive inflation-extension behavior of both regions of the swine colon (coefficient of determination R(2)=0...
August 31, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28922492/highly-sensitive-detection-of-protein-biomarkers-with-organic-electrochemical-transistors
#12
Ying Fu, Naixiang Wang, Anneng Yang, Helen Ka-Wai Law, Li Li, Feng Yan
The analysis of protein biomarkers is of great importance in the diagnosis of diseases. Although many convenient and low-cost electrochemical approaches have been extensively investigated, they are not sensitive enough in the detection of protein biomarkers with low concentrations in physiological environments. Here, this study reports a novel organic-electrochemical-transistor-based biosensor that can successfully detect cancer protein biomarkers with ultrahigh sensitivity. The devices are operated by detecting electrochemical activity on gate electrodes, which is dependent on the concentrations of proteins labeled with catalytic nanoprobes...
September 18, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28922309/quantifying-the-physiological-stress-response-to-simulated-maritime-pilotage-tasks-the-influence-of-task-complexity-and-pilot-experience
#13
Luana C Main, Alexander Wolkow, Timothy P Chambers
OBJECTIVE: The aim of this study was to quantify the stress associated with performing maritime pilotage tasks in a high-fidelity simulator. METHODS: Eight trainee and 13 maritime pilots completed two simulated pilotage tasks of varying complexity. Salivary cortisol samples were collected pre- and post-simulation for both trials. Heart rate was measured continuously throughout the study. RESULTS: Significant changes in salivary cortisol (P = 0...
September 15, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28922165/the-gastrointestinal-brain-axis-in-humans-as-an-evolutionary-advance-of-the-root-leaf-axis-in-plants-a-hypothesis-linking-quantum-effects-of-light-on-serotonin-and-auxin
#14
Lucio Tonello, Bekim Gashi, Alessandro Scuotto, Glenda Capello, Massimo Cocchi, Fabio Gabrielli, Jack A Tuszynski
Living organisms tend to find viable strategies under ambient conditions that optimize their search for, and utilization of, life-sustaining resources. For plants, a leading role in this process is performed by auxin, a plant hormone that drives morphological development, dynamics, and movement to optimize the absorption of light (through branches and leaves) and chemical "food" (through roots). Similarly to auxin in plants, serotonin seems to play an important role in higher animals, especially humans. Here, it is proposed that morphological and functional similarities between (i) plant leaves and the animal/human brain and (ii) plant roots and the animal/human gastro-intestinal tract have general features in common...
September 15, 2017: Journal of Integrative Neuroscience
https://www.readbyqxmd.com/read/28921823/encoding-seasonal-information-in-a-two-oscillator-model-of-the-multi-oscillator-circadian-clock
#15
Jihwan Myung, Scott D Pauls
The suprachiasmatic nucleus (SCN) is a collection of about 10,000 neurons, each of which functions as a circadian clock with slightly different periods and phases, that work in concert to form and maintain the master circadian clock for the organism. The diversity among neurons confers on the SCN the ability to robustly encode both the 24-hour light pattern as well as the seasonal time. Cluster synchronization brings the different neurons into line and reduces the large population to essentially two oscillators, coordinated by a macroscopic network motif of asymmetric repulsive-attractive coupling...
September 16, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28920447/synthesis-and-cytotoxic-activity-of-4-o-%C3%AE-d-galactopyranosyl-derivatives-of-phenolic-acids-esters
#16
Nader Al Bujuq, Sharif Arar, Raida Khalil
The glycosylation of naturally occurring phenolic acids has a significant impact on their solubility, stability and physiochemical properties. D-Galactose residue was found to form a part of glycoconjugates in several tissues and involved in a variety of physiological process. To the best of our knowledge, we have noticed a little information about the glycosylation of the phenolic acids with galactose residue. In this work, we describe the glycosylation of methyl vanillate and methyl ferulate with peracetylated-β-D-galactopyranose in the presence of BF3·OEt2...
September 18, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28918768/postnatal-developmental-changes-in-fractal-complexity-of-giemsa-stained-chromatin-in-mice-spleen-follicular-cells
#17
Igor Pantic, Jovana Paunovic, Danijela Vucevic, Tatjana Radosavljevic, Stefan Dugalic, Anita Petkovic, Sanja Radojevic-Skodric, Senka Pantic
Although there are numerous recent works focusing on fractal properties of DNA and chromatin, many issues regarding changes in chromatin fractality during physiological aging remain unclear. In this study, we present results indicating that in mice, there is an age-related reduction of chromatin fractal complexity in a population of spleen follicular cells (SFCs). Spleen tissue was obtained from 16 mice and fixated in Carnoy solution. The youngest animal was newborn, and each animal was exactly 1 month older than the previous...
September 18, 2017: Microscopy and Microanalysis
https://www.readbyqxmd.com/read/28918670/ph-sensitive-metal-phenolic-network-capsules-for-targeted-photodynamic-therapy-against-cancer-cells
#18
Yuanqing Wei, Zhenzhen Wei, Peicheng Luo, Wei Wei, Songqin Liu
Photodynamic therapy (PDT) is an effective and promising method for cancer treatment, which is proposed for more than one century. However, the specific delivery of photosensitizer to target carcinoma cells to reduce the side effect is still a great challenge. This work provides a strategy to deliver photosensitizers to cancer cells by utilizing pH-sensitive polyethylene glycol metal-phenolic network (PEG-MPN) capsules to encapsulate haematoporphyrin monomethyl ether (HMME). With the assistance of folic acid (FA), HMME-doped PEG-MPN capsules (MPN@HMMEs) accumulate in carcinoma cells selectively followed by releasing HMME in the lysosomes because of the physiologically relevant acidic pH environment...
September 18, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28918003/relevance-of-adding-a-triangular-dynamic-cushion-on-a-traditional-chair-a-3d-analysis-of-seated-schoolchildren
#19
T Fettweis, M N Onkelinx, C Schwartz, C Demoulin, J L Croisier, M Vanderthommen
BACKGROUND: Low back pain is highly prevalent in the general population and is even reported as early as at primary school. A poor sitting position has been suggested as an etiologic factor. This study analysed, in primary schoolchildren, the influence of a triangular dynamic cushion that aims to help children maintain their physiological lumbar lordosis and to induce movement to reduce the static effect of the sitting position. METHODS: Thirty 8-year-old children took part in this study...
September 8, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28917853/preparation-and-biological-activity-studies-of-resveratrol-loaded-ionically-cross-linked-chitosan-tpp-nanoparticles
#20
Jie Wu, Yaping Wang, Hao Yang, Xiangyu Liu, Zhong Lu
Nanoparticles with size range of 10-500nm can be efficiently delivered into cancer cells by the Enhanced Permeability and Retention (EPR) effect. Here, we prepared resveratrol (Res) loaded chitosan (CS) nanoparticles with the size of 172-217nm by an ionic cross-linking method, with sodium tripolyphosphate (TPP) as the cross-linking agent, to improve the stability, solubility and tumors targeting of the natural anti-cancer drug Res. The prepared Res loaded CS-TPP nanoparticles presented long-term storage stability and UV light stability...
November 1, 2017: Carbohydrate Polymers
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