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Copeptin fetal growth restriction

Despina D Briana, Maria Boutsikou, Theodora Boutsikou, Thanasis Dodopoulos, Dimitrios Gourgiotis, Ariadne Malamitsi-Puchner
OBJECTIVE: Intrauterine-growth-restriction-(IUGR) is associated with chronic fetal stress, as well as a phase of enhanced fetal/early postnatal insulin sensitivity, followed by a later emergence of insulin resistance. We aimed to prospectively investigate concentrations of copeptin, a sensitive marker of stress and insulin resistance, in IUGR versus appropriate-for-gestational-age-(AGA) fetuses. METHODS: Cord blood copeptin concentrations were determined by ELISA in well-defined, non-distressed at birth, asymmetric IUGR (n = 30) and AGA (n = 20) full-term pregnancies...
March 2017: Journal of Maternal-fetal & Neonatal Medicine
Gül Alkan Bülbül, Selahattin Kumru, Onur Erol, Bekir Sıtkı Isenlik, Ozgür Ozdemir, Mete Cağlar, Musa Yılmaz, Mehmet Kalaycı, Süleyman Aydın
Abstract Objective: The aim of this study was to compare maternal and fetal serum copeptin concentrations in pregnancies complicated by isolated fetal growth restriction (FGR), and uncomplicated pregnancies, and to investigate relationships between copeptin levels and clinical parameters. Methods: Maternal and fetal serum copeptin levels were measured in 21 women with pregnancies complicated by isolated FGR and 20 women with normal pregnancies (control group). Doppler assessment of the uterine and umbilical arteries was performed in each patient...
August 18, 2014: Journal of Maternal-fetal & Neonatal Medicine
Tilo Burkhardt, Sarah Schwabe, Nils G Morgenthaler, Giancarlo Natalucci, Roland Zimmermann, Sven Wellmann
OBJECTIVE: To compare venous cord plasma concentrations of 4 vasoactive peptide precursors: carboxy-terminal proarginine vasopressin, CT-prondothelin (ET)-1, midregional proadrenomedullin, and MR-proatrial natriuretic peptide, between fetuses with intrauterine growth restriction and appropriate for gestational age controls. STUDY DESIGN: Matched-pair analysis of 12 fetuses with significant intrauterine growth restriction and 42 healthy appropriate for gestational age control fetuses...
December 2012: American Journal of Obstetrics and Gynecology
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