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https://www.readbyqxmd.com/read/28651179/sedentary-work-and-the-risks-of-colon-and-rectal-cancer-by-anatomical-sub-site-in-the-canadian-census-health-and-environment-cohort-canchec
#1
Manisha Pahwa, M Anne Harris, Jill MacLeod, Michael Tjepkema, Paul A Peters, Paul A Demers
BACKGROUND: Sedentary behaviour is a potential risk factor for colorectal cancer. We examined the association between sedentary work, based on body position, and colorectal cancer risk in Canadians. METHODS: A working body position category (a. sitting; b. standing and walking; c. sitting, standing, and walking; d. other) was assigned to occupations reported by 1991 Canadian Census respondents based on national occupational counselling guidelines. Adjusted hazard ratios (HRs) and 95% confidence intervals (CI) were estimated for cancers of the colon (overall, proximal, and distal) and rectum in men and women newly diagnosed from 1992 to 2010...
June 23, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28650892/the-2017-hormone-therapy-position-statement-of-the-north-american-menopause-society
#2
(no author information available yet)
The 2017 Hormone Therapy Position Statement of The North American Menopause Society (NAMS) updates the 2012 Hormone Therapy Position Statement of The North American Menopause Society and identifies future research needs. An Advisory Panel of clinicians and researchers expert in the field of women's health and menopause was recruited by NAMS to review the 2012 Position Statement, evaluate new literature, assess the evidence, and reach consensus on recommendations, using the level of evidence to identify the strength of recommendations and the quality of the evidence...
June 22, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28650869/the-2017-hormone-therapy-position-statement-of-the-north-american-menopause-society
#3
(no author information available yet)
The 2017 Hormone Therapy Position Statement of The North American Menopause Society (NAMS) updates the 2012 Hormone Therapy Position Statement of The North American Menopause Society and identifies future research needs. An Advisory Panel of clinicians and researchers expert in the field of women's health and menopause was recruited by NAMS to review the 2012 Position Statement, evaluate new literature, assess the evidence, and reach consensus on recommendations, using the level of evidence to identify the strength of recommendations and the quality of the evidence...
July 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28650843/can-canmeds-competencies-be-developed-in-medical-school-anatomy-laboratories-a-literature-review
#4
REVIEW
Joshua Hefler, Christopher J Ramnanan
Objectives: The purpose of this literature review was to identify potential ways in which undergraduate medical anatomy education may be relevant to the CanMEDS Roles, a competency-based framework used throughout Canadian medical training. Methods: A scoping review of medical education literature was conducted in March 2017 for English language publications that included key words related to anatomy education and to key competencies formally described for each of the Roles in the CanMEDS 2015 framework...
June 16, 2017: International Journal of Medical Education
https://www.readbyqxmd.com/read/28649236/the-validation-and-implications-of-using-whole-genome-sequencing-as-a-replacement-for-traditional-serotyping-for-a-national-salmonella-reference-laboratory
#5
Chris A Yachison, Catherine Yoshida, James Robertson, John H E Nash, Peter Kruczkiewicz, Eduardo N Taboada, Matthew Walker, Aleisha Reimer, Sara Christianson, Anil Nichani, Celine Nadon
Salmonella serotyping remains the gold-standard tool for the classification of Salmonella isolates and forms the basis of Canada's national surveillance program for this priority foodborne pathogen. Public health officials have been increasingly looking toward whole genome sequencing (WGS) to provide a large set of data from which all the relevant information about an isolate can be mined. However, rigorous validation and careful consideration of potential implications in the replacement of traditional surveillance methodologies with WGS data analysis tools is needed...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28648856/presentations-for-hypoglycemia-associated-with-diabetes-mellitus-to-emergency-departments-in-a-canadian-province-a-database-and-epidemiological-analysis
#6
Chris J Alexiu, Anderson Chuck, Susan E Jelinski, Brian H Rowe
AIMS: The prevalence of diabetes mellitus was reportedly 9% in 2014, making it one of the most common global chronic conditions. Hypoglycemia is an important complication of diabetes treatment. The objective of this study was to quantify and characterize hypoglycemia presentations associated with type 1 or 2 diabetes made to emergency departments (EDs) by adults in a Canadian province. METHODS: A retrospective cohort study was conducted using reliable administrative data from Alberta for a five-year period (2010/11-2014/15)...
March 11, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28648852/barriers-to-goals-of-care-discussions-with-patients-who-have-advanced-heart-failure-results-of-a-multi-centre-survey-of-hospital-based-cardiology-clinicians
#7
John J You, Natasha Aleksova, Anique Ducharme, Jane MacIver, Lisa Mielniczuk, Robert A Fowler, Catherine Demers, Brian Clarke, Marie-Claude Parent, Mustafa Toma, Patricia H Strachan, Paul Farand, Debra Isaac, Shelley Zieroth, Marilyn Swinton, Xuran Jiang, Andrew G Day, Daren K Heyland, Heather J Ross
BACKGROUND: Conversations about goals of care in hospital are important to patients who have advanced heart failure (HF). METHODS: We conducted a multi-centre survey of cardiology nurses, fellows, and cardiologists at 8 Canadian teaching hospitals. The primary outcome was the importance of barriers to goals of care discussions in hospital (1=extremely unimportant; 7=extremely important). We also elicited perspectives on roles of different practitioners in having these conversations...
June 22, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28648765/adherence-to-diabetes-dietary-guidelines-assessed-using-a-validated-questionnaire-predicts-glucose-control-in-individuals-with-type-2-diabetes
#8
Gayathiri Durai Raj, Zohre Hashemi, Diana C Soria Contreras, Stephanie Babwik, Denise Maxwell, Rhonda C Bell, Catherine B Chan
OBJECTIVES: The purpose of this study was to determine predominant deviations from Canadian Diabetes Association (CDA) nutrition therapy guidelines for Canadians with type 2 diabetes as a prelude to developing relevant interventions. We hypothesized that lack of adherence to these guidelines would be associated with higher glycated hemoglobin (A1C) levels. METHODS: A cross-sectional trial was conducted to evaluate associations between dietary adherence to CDA and Health Canada guidelines and blood glucose control...
June 22, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28647626/smoking-cessation-rates-amongst-patients-undergoing-vascular-surgery-in-a-canadian-center
#9
S M McHugh, N Eisenberg, J Montbriand, G Roche-Nagle
INTRODUCTION: Smoking is the single most important modifiable risk factor for patients with vascular disease. The aim of this study was to determine prevalence of smoking and cessation rates amongst patients undergoing vascular surgery in a Canadian centre. METHODS: As part of the Vascular Quality Initiative (VQI), a prospectively maintained database was used to identify the patents undergoing vascular surgery between 2010 and 2013. Smoking prevalence data was collated pre-procedure, post-procedure, and at year follow up post intervention at a median of 13 months (Mean = 14...
June 21, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28647574/a-rare-uterine-malformation-asymmetric-septate-uterus
#10
Alper Biler, Ali Akdemir, Nuri Peker, Fatih Sendag
STUDY OBJECTIVE: To demonstrate a step by step surgical hysteroscopy technique in a patient with asymmetric uterine septum and transverse uterine septum that was not previously described in the literature. DESIGN: Resection of a asymmetric uterine septum by laparoscopy and ultrasound-guided hysteroscopy (Canadian Task Force Classification III). The video was assumed exempt from official review by our institutional review board. SETTING: A septate uterus is defined as the uterus in which the uterine cavity is longitudinally divided by the septum (1)...
June 21, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28647526/national-survey-of-adult-and-pediatric-reference-intervals-in-clinical-laboratories-across-canada-a-report-of-the-cscc-working-group-on-reference-interval-harmonization
#11
Khosrow Adeli, Victoria Higgins, David Seccombe, Christine P Collier, Cynthia Balion, George Cembrowski, Allison A Venner, Julie Shaw
OBJECTIVE: Reference intervals are widely used decision-making tools in laboratory medicine, serving as health-associated standards to interpret laboratory test results. Numerous studies have shown wide variation in reference intervals, even between laboratories using assays from the same manufacturer. Lack of consistency in either sample measurement or reference intervals across laboratories challenges the expectation of standardized patient care regardless of testing location. Here, we present data from a national survey conducted by the Canadian Society of Clinical Chemistry (CSCC) Reference Interval Harmonization (hRI) Working Group that examines the variation in laboratory reference sample measurements, as well as pediatric and adult reference intervals currently used in clinical practice across Canada...
June 21, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28647446/social-and-geographic-determinants-of-hysterectomy-in-ontario-a-population-based-retrospective-cross-sectional-analysis
#12
Innie Chen, Michelle R Wise, Sheila Dunn, Geoffrey Anderson, Naushaba Degani, Guylaine Lefebvre, Arlene S Bierman
OBJECTIVES: This study sought to determine whether social factors (neighbourhood education and income) and geographic factors (urban or rural dwelling and local service area) are associated with hysterectomy rates, proportion of hysterectomies performed minimally invasively, and hysterectomy complication and readmission rates in Ontario. METHODS: The Canadian Institute for Health Information Discharge Abstract Database was used to perform a population-based retrospective cross-sectional study on women who had an abdominal, vaginal, and laparoscopic hysterectomy in 2007 for benign gynaecologic conditions in hospitals in Ontario, Canada...
June 21, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28646937/comparison-of-external-beam-radiotherapy-versus-permanent-seed-brachytherapy-as-monotherapy-for-intermediate-risk-prostate-cancer-a-single-center-canadian-experience
#13
Guila Delouya, Carole Lambert, Jean-Paul Bahary, Marie-Claude Beauchemin, Maroie Barkati, Cynthia Ménard, Daniel Taussky
INTRODUCTION: We tested different classification systems in order to separate intermediate-risk prostate cancers into prognostic groups. We then examined which groups were most suited for either prostate seed brachytherapy (PB) or external beam radiotherapy (EBRT). MATERIALS AND METHODS: We selected patients with D'Amico intermediate-risk prostate cancer who were treated exclusively with either PB or EBRT. Patients were excluded if they had received androgen deprivation therapy in combination with EBRT or a follow up of < 30 months without recurrence...
June 2017: Canadian Journal of Urology
https://www.readbyqxmd.com/read/28646457/national-survey-among-radiation-oncology-residents-related-to-their-needs-in-geriatric-oncology
#14
Rachel Leifer, Bonnie Bristow, Martine Puts, Shabbir Alibhai, Xingshan Cao, Barbara-Ann Millar, Meredith Giuliani, Tina Hsu, Maureen Trudeau, Rajin Mehta, Ines Menjak, Mireille Norris, Barbara Liu, Francois Gallant, Ewa Szumacher
Currently, there is no formal curriculum addressing geriatric oncology within Canadian radiation oncology (RO) residency programs. Knowledge related to geriatric medicine may help radiation oncologists modify RT based on frailty status and geriatric considerations. Understanding specific learning needs allow program coordinators to align the current curriculum with residents' geriatric oncology learning needs. The purpose of this study is to determine the geriatric oncology educational needs of the Canadian RO residents and to inform Canadian RO residency training...
June 24, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28646019/functionally-null-rad51d-missense-mutation-associates-strongly-with-ovarian-carcinoma
#15
Barbara Rivera, Massimo Di Iorio, Jessica Frankum, Javad Nadaf, Somayyeh Fahiminiya, Suzanna L Arcand, David L Burk, Damien Grapton, Eva Tomiak, Valerie Hastings, Nancy Hamel, Rabea Wagener, Olga Aleynikova, Sylvie Giroux, Fadi F Hamdan, Alexandre Dionne-Laporte, George Zogopoulos, Francois Rousseau, Albert M Berghuis, Diane Provencher, Guy A Rouleau, Jacques L Michaud, Anne-Marie Mes-Masson, Jacek Majewski, Susanne Bens, Reiner Siebert, Steven A Narod, Mohammad R Akbari, Christopher J Lord, Patricia N Tonin, Alexandre Orthwein, William D Foulkes
RAD51D is a key player in DNA repair by homologous recombination (HR) and RAD51D truncating mutation carriers have an increased risk for ovarian cancer (OC). However, the contribution of non-truncating RAD51D variants to cancer predisposition remains uncertain. Using deep sequencing and case-control genotyping studies, we show that in French Canadians, the missense RAD51D variant c.620C>T;p.S207L is highly prevalent and is associated with a high risk for ovarian high-grade serous carcinoma (HGSC) (3.8% cases vs 0...
June 23, 2017: Cancer Research
https://www.readbyqxmd.com/read/28645956/exploring-the-components-of-physician-volunteer-engagement-a-qualitative-investigation-of-a-national-canadian-simulation-based-training-programme
#16
Aimee J Sarti, Stephanie Sutherland, Angele Landriault, Kirk DesRosier, Susan Brien, Pierre Cardinal
OBJECTIVES: Conceptual clarity on physician volunteer engagement is lacking in the medical literature. The aim of this study was to present a conceptual framework to describe the elements which influence physician volunteer engagement and to explore volunteer engagement within a national educational programme. SETTING: The context for this study was the Acute Critical Events Simulation (ACES) programme in Canada, which has successfully evolved into a national educational programme, driven by physician volunteers...
June 23, 2017: BMJ Open
https://www.readbyqxmd.com/read/28645803/grace-risk-score-sex-based-validity-of-in-hospital-mortality-prediction-in-canadian-patients-with-acute-coronary-syndrome
#17
Inna Y Gong, Shaun G Goodman, David Brieger, Chris P Gale, Derek P Chew, Robert C Welsh, Thao Huynh, J Paul DeYoung, Carolyn Baer, Gabor T Gyenes, Jacob A Udell, Keith A A Fox, Andrew T Yan
BACKGROUND: Although there are sex differences in management and outcome of acute coronary syndromes (ACS), sex is not a component of Global Registry of Acute Coronary Events (GRACE) risk score (RS) for in-hospital mortality prediction. We sought to determine the prognostic utility of GRACE RS in men and women, and whether its predictive accuracy would be augmented through sex-based modification of its components. METHODS: Canadian men and women enrolled in GRACE and Canadian Registry of Acute Coronary Events were stratified as ST-segment elevation myocardial infarction (STEMI) or non-ST-segment elevation ACS (NSTE-ACS)...
June 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28644929/short-interpregnancy-intervals-maternal-folate-levels-and-infants-born-small-for-gestational-age-a-preliminary-study-in-a-canadian-supplement-using-population
#18
Buffy Chen, Prescilla Carrion, Ravneet Grewal, Angela Inglis, Catriona Hippman, Emily Morris, Heather J Andrighetti, Arianne Albert, Jehannine Austin
BACKGROUND: Short interpregnancy intervals (SIPI) have been associated with increased risks for adverse neonatal outcomes including preterm delivery and infants small for gestational age (SGA). It has been suggested that mechanistically, adverse neonatal outcomes after SIPI arise due to insufficient recovery of depleted maternal folate levels prior to the second pregnancy. However, empirical data are lacking regarding physiological folate levels in pregnant women with SIPI, and relationships between quantified physiological folate levels and outcomes like SGA...
June 23, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28644778/impact-of-economic-hardship-and-financial-threat-on-suicide-ideation-and-confusion
#19
Lisa Fiksenbaum, Zdravko Marjanovic, Esther Greenglass, Francisco Garcia-Santos
The present study tested the extent to which perceived economic hardship is associated with psychological distress (suicide ideation and confusion) after controlling for personal characteristics. It also explored whether perceived financial threat (i.e., fearful anxious-uncertainty about the stability and security of one's personal financial situation) mediates the relationship between economic hardship and psychological distress outcomes. The theoretical model was tested in a sample of Canadian students (n = 211) and was validated in a community sample of employed Portuguese adults (n = 161)...
July 4, 2017: Journal of Psychology
https://www.readbyqxmd.com/read/28644580/a-free-ride-an-analysis-of-the-association-of-casino-bus-tours-and-problem-gambling-among-older-adults
#20
Mark van der Maas, Robert E Mann, Flora I Matheson, Nigel E Turner, Hayley A Hamilton, John McCready
BACKGROUND AND AIMS: Little research has examined the relationship between incentives used by gambling venues to attract customers and the experience of gambling related harm. Organized and subsidized bus tours are a common example of such incentives. The aim of this study was to examine whether bus tour patronage was associated with increased odds of problem gambling among older adults. This study also compared rates of bus tour use by sociodemographic characteristics and gambling behaviours...
June 23, 2017: Addiction
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