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https://www.readbyqxmd.com/read/28737775/fertility-preservation-issues-in-pediatric-hematopoietic-stem-cell-transplantation-practical-approaches-from-the-consensus-of-the-pediatric-diseases-working-party-of-the-ebmt-and-the-international-bfm-study-group
#1
A Balduzzi, J-H Dalle, K Jahnukainen, M von Wolff, G Lucchini, M Ifversen, K T Macklon, C Poirot, T Diesch, A Jarisch, D Bresters, I Yaniv, B Gibson, A M Willasch, R Fadini, L Ferrari, A Lawitschka, A Ahler, N Sänger, S Corbacioglu, M Ansari, R Moffat, A Dalissier, E Beohou, P Sedlacek, A Lankester, C D De Heredia Rubio, K Vettenranta, J Wachowiak, A Yesilipek, E Trigoso, T Klingebiel, C Peters, P Bader
Fertility preservation is an urgent challenge in the transplant setting. A panel of transplanters and fertility specialists within the Pediatric Diseases Working Party of the European Society for Blood and Marrow Transplantation (EBMT) and the International BFM Study Group provides specific guidelines. Patients and families should be informed of possible gender- and age-specific cryopreservation strategies that should be tailored according to the underlying disease, clinical condition and previous exposure to chemotherapy...
July 24, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28737761/glutamate-receptor-like-channels-are-essential-for-chemotaxis-and-reproduction-in-mosses
#2
Carlos Ortiz-Ramírez, Erwan Michard, Alexander A Simon, Daniel S C Damineli, Marcela Hernández-Coronado, Jörg D Becker, José A Feijó
Glutamate receptors are well characterized channels that mediate cell-to-cell communication during neurotransmission in animals. Nevertheless, information regarding their functional role in organisms without nervous systems is still limited. In plants, Glutamate Receptor-like (GLR) genes have been implicated in defence against pathogens, reproduction, control of stomata aperture and light signal transduction(1-5). However, the numerous GLR genes present in angiosperm genomes (20 to 70)(6) has prevented the observation of strong phenotypes in loss-of-function mutants...
July 24, 2017: Nature
https://www.readbyqxmd.com/read/28737271/in-vitro-fertilization-and-pregnancy-management-in-a-woman-with-acquired-idiopathic-chylous-ascites
#3
Ai Sakamoto, Yasuhiko Kamada, Sayoko Kotani, Kiyoshi Yamada, Yoshihiro Kimata, Yuji Hiramatsu
Acquired idiopathic chylous ascites is extremely rare in women of reproductive age. This is the first report describing successful infertility and pregnancy management in a patient with idiopathic chylous ascites. A 23-year-old woman presented with abdominal distention and was diagnosed with idiopathic fluid collection. A lymphogram revealed lymphatic leakage from the right renal hilum. Lymphatic-venous anastomosis of the thoracic duct was performed thrice, but the chylous ascites persisted. In vitro fertilization was performed because natural conception was not possible...
July 24, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28736964/exceptionalism-is-not-exceptional-in-relation-to-sexual-and-reproduction-mechanisms-contrasts-of-human-and-animal-sexuality
#4
REVIEW
Roy J Levin
Speculation that the release of oxytocin by orgasm in the human female during coitus facilitates fertility by enhancing uterine sperm transport has been criticised as having no unequivocal empirical human evidence. However, a counter claim that this supports human 'exceptionalism' as some form of uterine sperm transport occurs in other species. This is a misconception as it ignores that human uterine peristalsis, powered by contractions of the smooth muscle of the archimyometrium, facilitates sperm transport even without any systemic oxytocin involvement...
July 24, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28736861/azadirachtin-effects-on-mating-success-gametic-abnormalities-and-progeny-survival-in-drosophila-melanogaster-diptera
#5
Chemseddine M Oulhaci, Béatrice Denis, Samira Kilani-Morakchi, Jean-Christophe Sandoz, Laure Kaiser, Dominique Joly, Nadia Aribi
BACKGROUND: Azadirachtin is a prominent natural pesticide and represents an alternative to conventional insecticides. It has been successfully used against insect pests. However, its effects on reproduction require further analysis. Here we investigated lethal and sublethal effects of azadirachtin, on treated adults in a model insect, Drosophila melanogaster (Meigen). Dose-mortality relationships as well as several parameters of reproduction (mating, spermatogenesis, oogenesis and fertility) were examined...
July 24, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28736365/-blighted-ovum-in-subfertile-patients-undergoing-assisted-reproductive-technology
#6
Qing-Wen Nie, Rui Hua, Yao Zhou, Hong Li, Yan-Hong Yu
OBJECTIVE: To explore the incidence and risk factors of blighted ovum in subfertile patients undergoing assisted reproductive technology (ART). METHODS: This retrospective analysis was conducted among 2378 patients who were pregnant following embryo transfer at our center from January, 2012 to December, 2015, including cases of early pregnancy losses and simultaneous live births. The cases with early pregnancy losses were divided into embryonic pregnancy and blighted ovum groups based on the presence or absence of an embryonic pole before dilation and curettage...
July 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28735888/differential-expression-of-subunits-of-20%C3%AE-hydroxysteroid-dehydrogenase-during-gametogenesis-in-rainbow-trout-oncorhychus-mykiss
#7
Arya Vazirzadeh, Yann Guiguen
The patterns of expression of two subunits of 20β-hydroxysteroid dehydrogenase (20β-HSD), key enzyme involved in the biosynthesis and activation of steroid hormones, were examined in rainbow trout by using a combination of quantitative real-time PCR and in-situ hybridization. The expression of targeted genes was examined in mRNA extracted from different tissues at different gonadal stages in male and female trout. Both subunits of 20β-HSD were found to be widely distributed in tissues. The highest expression of 20β-HSD A was found in intestine followed by skin, stomach, liver and gills, whereas, the highest expression of 20β-HSD B was observed in stomach followed by head kidney, ovary - at late vitellogenesis stage- and trunk kidney...
July 14, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28735705/impact-of-preimplantation-genetic-screening-on-donor-oocyte-recipient-cycles-in-the-united-states
#8
David H Barad, Sarah K Darmon, Vitaly A Kushnir, David F Albertini, Norbert Gleicher
OBJECTIVE: Our objective was to estimate the contribution of Preimplantation genetic screening to in-vitro fertilization pregnancy outcomes in donor oocyte-recipient cycles. METHODS: This is a retrospective cross-sectional study of United States national data from the Society for Assisted Reproductive Technology Clinic Outcome Reporting System between 2005-2013. Society for Assisted Reproductive Technology Clinic Outcome Reporting relies on voluntarily annual reports by over 90% of United States in-vitro fertilization centers...
July 20, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28734119/a-systematic-review-of-patient-oncofertility-support-needs-in-reproductive-cancer-patients-aged-14-to-45-years-of-age
#9
REVIEW
S Logan, J Perz, J M Ussher, M Peate, A Anazodo
OBJECTIVE: Decline in fertility potential brought about by a cancer diagnosis or cancer treatment is one of the biggest impacts to cancer patients' long term quality of life. As such, the current manuscript aimed to systematically review the literature on oncofertility support needs for cancer patients of a reproductive age (14-45 years of age). METHODS: A systematic review of the literature was conducted in May 2016 through the searching of electronic databases Medline, EMBASE, PSYCH Info, Web of Science and SCOPUS, alongside the screening of relevant reference lists...
July 22, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28733801/effect-of-follicular-flushing-on-reproductive-outcomes-in-patients-with-poor-ovarian-response-undergoing-assisted-reproductive-technology
#10
Anna L M Souza, Marcos Sampaio, Graciele B Noronha, Ludiana G R Coster, Roberta S G de Oliveira, Selmo Geber
PURPOSE: The purpose of this study is to investigate the impact of follicular flushing on the number of oocytes retrieved, oocyte maturity, fertilization rate, embryo development, and pregnancy rate of poor ovarian responders (POR). METHODS: Retrospective study of 524 cycles of 384 patients with POR submitted to assisted reproductive technology (ART) and who had follicular flushing during oocyte retrieval was used in the study. We included patients with <5 oocytes at oocyte retrieval (POR group) and matching the Bologna criteria...
July 21, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28732531/endometrial-scratching-in-women-with-implantation-failure-after-a-first-ivf-icsi-cycle-does-it-lead-to-a-higher-live-birth-rate-the-scratch-study-a-randomized-controlled-trial-ntr-5342
#11
N E van Hoogenhuijze, H L Torrance, F Mol, J S E Laven, E Scheenjes, M A F Traas, C Janssen, B Cohlen, G Teklenburg, J P de Bruin, R van Oppenraaij, J W M Maas, E Moll, K Fleischer, M H van Hooff, C de Koning, A Cantineau, C B Lambalk, M Verberg, M Nijs, A P Manger, M van Rumste, L F van der Voet, A Preys-Bosman, J Visser, E Brinkhuis, J E den Hartog, A Sluijmer, F W Jansen, W Hermes, M L Bandell, M J Pelinck, J van Disseldorp, M van Wely, J Smeenk, Q D Pieterse, J C Boxmeer, E R Groenewoud, M J C Eijkemans, J C Kasius, F J M Broekmans
BACKGROUND: Success rates of assisted reproductive techniques (ART) are approximately 30%, with the most important limiting factor being embryo implantation. Mechanical endometrial injury, also called 'scratching', has been proposed to positively affect the chance of implantation after embryo transfer, but the currently available evidence is not yet conclusive. The primary aim of this study is to determine the effect of endometrial scratching prior to a second fresh in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycle on live birth rates in women with a failed first IVF/ICSI cycle...
July 21, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28732252/update-on-medical-treatment-of-uterine-fibroids
#12
REVIEW
Fátima Faustino, Margarida Martinho, José Reis, Fernanda Águas
OBJECTIVES: In this review paper, the pros and cons of the available pharmacological options for the treatment of uterine fibroids are explored, including oral progestogens, levonorgestrel intra-uterine device, gonadotropin-releasing hormone analogs and progesterone receptor modulators with an emphasis on ulipristal acetate. STUDY DESIGN: The choice of the appropriate therapeutic approach for uterine fibroids depends on several factors, including women's age, parity, childbearing aspirations and wish to preserve fertility, extent and severity of symptoms, size, number and location of myomas, risk of malignancy and proximity to menopause...
July 8, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28732173/exploring-the-potential-of-gametic-reconstruction-of-parental-genotypes-by-f-sub-1-sub-hybrids-as-a-bridge-for-rapid-introgression
#13
Charles H Cannon, C Lane Scher
Interspecific hybridization and genetic introgression are commonly observed in natural populations of many species, especially trees. Among oaks, gene flow between closely-related species has been well documented. And yet, hybridization does not lead to a 'melting pot', i.e. the homogenization of phenotypic traits. Here, we explore how the combination of several common reproductive traits and genomic biology could create an avenue for interspecific gene flow that partially explains this apparent paradox. During meiosis, F<sub>1</sub> hybrids will produce approximately (½)<sup>n</sup> 'reconstructed' parental gametes, where n equals the number of chromosomes...
July 21, 2017: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/28732077/mutations-in-the-caenorhabditis-elegans-orthologs-of-human-genes-required-for-mitochondrial-trna-modification-cause-similar-electron-transport-chain-defects-but-different-nuclear-responses
#14
Carmen Navarro-González, Ismaïl Moukadiri, Magda Villarroya, Ernesto López-Pascual, Simon Tuck, M-Eugenia Armengod
Several oxidative phosphorylation (OXPHOS) diseases are caused by defects in the post-transcriptional modification of mitochondrial tRNAs (mt-tRNAs). Mutations in MTO1 or GTPBP3 impair the modification of the wobble uridine at position 5 of the pyrimidine ring and cause heart failure. Mutations in TRMU affect modification at position 2 and cause liver disease. Presently, the molecular basis of the diseases and why mutations in the different genes lead to such different clinical symptoms is poorly understood...
July 21, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28731299/human-biomonitoring-of-lead-exposure
#15
Katrin Klotz, Thomas Göen
After a chronic exposure, lead accumulates in the human body, especially in bones and teeth. Critical effects of lead affect the nervous system, reproduction, fertility as well as genotoxicity and carcinogenicity [1]. Analyses of lead concentrations in human biological material are performed using inductively coupled plasma mass spectrometry and atomic absorption spectrometry, but also electrochemical methods and X-ray fluorescence spectroscopy. The predominant sample matrices include blood and bone, as well as urine, hair, nail, and saliva...
April 10, 2017: Metal Ions in Life Sciences
https://www.readbyqxmd.com/read/28729744/attitudes-towards-social-oocyte-freezing-from-a-socio-cultural-perspective
#16
Maren Schick, Réka Sexty, Beate Ditzen, Tewes Wischmann
INTRODUCTION: The tendency to delay parenthood is increasing. It is partly driven by the availability of early reproductive technologies such as social oocyte freezing, the cryopreservation of oocytes for non-medical purposes. The goal of this study was to investigate relationships between attitudes towards social oocyte freezing and different socio-cultural backgrounds in a German sample cohort. MATERIALS AND METHODS: A quantitative online questionnaire was compiled...
July 2017: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/28728362/estimation-of-genetic-parameters-of-the-productive-and-reproductive-traits-in-ethiopian-holstein-using-multi-trait-models
#17
Wondossen Ayalew, Mohammed Aliy, Enyew Negussie
Objective: The objective of this study was to estimate genetic parameters for productive and reproductive traits. Methods: The data included production and reproduction records of animals that have calved between 1979 and 2013. The genetic parameters were estimated using multivariate mixed models (DMU) package, fitting univariate and multivariate mixed models with average information restricted maximum likelihood (AI-REML) algorithm. Results: The estimates of heritability for milk production traits from the first three lactation records were 0...
June 27, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28728348/effect-of-antiretroviral-therapy-art-on-change-in-fertility-intentions-of-hiv-positive-women-in-addis-ababa-ethiopia-a-prospective-follow-up-study
#18
Hussen Mekonnen
Objectives: The study aimed to assess change in fertility intentions 12 months after ART initiation among HIV positive women in Addis Ababa, Ethiopia. Methods: Institution based follow up study was conducted, among 360 HIV positive women in Addis Ababa; from June 2012 to October 2013. Logistic regression model was used to assess the influence socio-demographic, reproductive health and clinical characteristics on the change in fertility intention of women. Results: Overall, 41...
July 16, 2017: Epidemiology and Health
https://www.readbyqxmd.com/read/28727724/grandmothering-and-cognitive-resources-are-required-for-the-emergence-of-menopause-and-extensive-post-reproductive-lifespan
#19
Carla Aimé, Jean-Baptiste André, Michel Raymond
Menopause, the permanent cessation of ovulation, occurs in humans well before the end of the expected lifespan, leading to an extensive post-reproductive period which remains a puzzle for evolutionary biologists. All human populations display this particularity; thus, it is difficult to empirically evaluate the conditions for its emergence. In this study, we used artificial neural networks to model the emergence and evolution of allocation decisions related to reproduction in simulated populations. When allocation decisions were allowed to freely evolve, both menopause and extensive post-reproductive life-span emerged under some ecological conditions...
July 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28726748/effect-of-air-pollution-on-menstrual-cycle-length-a-prognostic-factor-of-women-s-reproductive-health
#20
Anna Merklinger-Gruchala, Grazyna Jasienska, Maria Kapiszewska
Air pollution can influence women's reproductive health, specifically menstrual cycle characteristics, oocyte quality, and risk of miscarriage. The aim of the study was to assess whether air pollution can affect the length of the overall menstrual cycle and the length of its phases (follicular and luteal). Municipal ecological monitoring data was used to assess the air pollution exposure during the monitored menstrual cycle of each of 133 woman of reproductive age. Principal component analyses were used to group pollutants (PM10, SO₂, CO, and NOx) to represent a source-related mixture...
July 20, 2017: International Journal of Environmental Research and Public Health
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