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Ventricular tachycardia localization

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https://www.readbyqxmd.com/read/29113751/cardiomyopathy-induced-by-incessant-ventricular-tachycardia-originating-in-the-vicinity-of-the-his-bundle
#1
Sana Ouali, Manel Ben Halima, Selim Boudiche, Anissa Gharbi, Khedher Nadim, Kaouthar Hakim, Fatma Ouarda, Mohamed Sami Mourali
A 04-year-old boy was referred to our institution with severe, progressive heart failure of 4-months duration associated with a persistent wide QRS tachycardia with left bundle branch block and severe left ventricular dysfunction. Because of incessant wide QRS tachycardia refractory to antiarrhythmic drugs, he was referred for electrophysiological study. The ECG was suggestive of VT arising from the right ventricle near the His area. Electrophysiological study revealed that origin of tachycardia was septum of the right ventricle, near His bundle, however the procedure was not successful and an inadvertent complete atrioventricular conduction block occurred...
November 4, 2017: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/29068108/evaluation-of-sustained-tachyarrhythmia-in-children-younger-than-one-year-of-age
#2
Gulhan Tunca Sahin, Erkut Ozturk, Taner Kasar, Alper Guzeltas, Yakup Ergul
BACKGROUND: In this study, we aim to evaluate the results of non-operational sustained tachyarrhythmias in patients younger than 1 year of age in our center. METHODS: Between November 2010 and November 2016, the demographic characteristics, type and localization of the tachyarrhythmia, echocardiographic findings, and medical and/or ablation therapies applied for patients under 1 year of age who had sustained tachyarrhythmias were evaluated. RESULTS: Among 99 patients, 91 had sustained supraventricular tachycardia, and eight had sustained ventricular tachycardia...
October 25, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29035207/novel-quantitative-analytical-approaches-for-rotor-identification-and-associated-implications-for-mapping
#3
Elizabeth M Annoni, Shivaram Poigai Arunachalam, Suraj Kapa, Siva K Mulpuru, Paul A Friedman, Elena G Talkachova
OBJECTIVE: Clinical studies identifying rotors confirming these sites for ablation in treating cardiac arrhythmias have had inconsistent results with the current analysis techniques available. The aim of this study is to evaluate four new signal analysis approaches - multiscale frequency (MSF), Shannon entropy (SE), Kurtosis (Kt), and multiscale entropy (MSE) - in their ability to identify the pivot point of rotors. METHODS: Optical mapping movies of ventricular tachycardia were used to evaluate the performance and robustness of SE, Kt, MSF and MSE techniques with respect to several clinical limitations: decreased time duration, reduced spatial resolution, and the presence of meandering rotors...
October 16, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28857212/normal-123-i-mibg-uptake-areas-may-be-associated-with-hyperinnervation-and-arrhythmia-risk-in-phenol-model-rabbit-hearts
#4
Mari Amino, Koichiro Yoshioka, Sachie Tanaka, Noboru Kawabe, Hiroyuki Kurosawa, Keisuke Uchida, Shinobu Oshikiri, Tadashi Hashida, Shigetaka Kanda, Sadaki Inokuchi, Yuji Ikari
BACKGROUND: Iodine-123 metaiodobenzylguanidine ((123) I-MIBG) is useful for detecting sympathetic innervation in the heart, and has been closely associated with fatal arrhythmias. However, such imaging is typically calibrated to the area of highest uptake and thus is unable to identify areas of hyperinnervation. We hypothesized that normal (123) I-MIBG uptake regions in the denervated heart would demonstrate nerve sprouting and correlate with the potential for arrhythmogenesis. METHODS: Twenty New Zealand white rabbits treated with phenol or sham were prepared under anesthesia...
August 31, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28843747/arrhythmogenic-right-ventricular-cardiomyopathy-arvc-in-a-young-female-athlete-at-36-weeks-gestation-a-case-report
#5
Hae Yoon Grace Choung, Monika Vyas, Daniel Jacoby, Brian West
A 26year old east African professional athlete presented to the obstetric clinic for a routine visit at 36 weeks gestation. She had a history of Right Ventricular Outflow Tract - Ventricular Tachycardia (RVOT-VT) with an episode of cardiac arrest in the past, and had been treated with ablation 4 years earlier. Her current visit was uneventful, her pregnancy progressing normally. Following the visit she went to a local restaurant where she suffered a cardiac arrest that was unresponsive to therapy. Chest compressions were continued from the time of her collapse until an emergency caesarian section was performed, delivering a healthy female infant...
October 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28840101/radiofrequency-ablation-of-ventricular-tachycardia-originating-from-a-lipomatous-hamartoma-localized-in-the-right-ventricle-cavity
#6
Jin Xu, Yingmin Chen, Xiaoying Ying, Ben He
No abstract text is available yet for this article.
August 2017: HeartRhythm Case Reports
https://www.readbyqxmd.com/read/28770255/massive-accumulation-of-myofibroblasts-in%C3%A2-the-critical-isthmus-is-associated-with%C3%A2-ventricular-tachycardia-inducibility-in%C3%A2-post-infarct-swine-heart
#7
Tarvinder S Dhanjal, Nicolas Lellouche, Christopher J von Ruhland, Guillaume Abehsira, David H Edwards, Jean-Luc Dubois-Randé, Konstantinos Moschonas, Emmanuel Teiger, Alan J Williams, Christopher H George
OBJECTIVES: In this study the authors determined the extent of cellular infiltration and dispersion, and regional vascularization in electrophysiologically (EP) defined zones in post-myocardial infarction (MI) swine ventricle. BACKGROUND: The critical isthmus (CI) in post-MI re-entrant ventricular tachycardia (VT) is a target for catheter ablation. In vitro evidence suggests that myofibroblasts (MFB) within the scar border zone (BZ) may increase the susceptibility to slow conduction and VT, but whether this occurs in vivo remains unproven...
July 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/28765737/local-atrial-ventricular-ratio-as-an-adjuvant-marker-for-catheter-ablation-of-atrioventricular-accessory-pathways
#8
Ki-Hun Kim, Dae-Kyeong Kim, Hyun-Ji Im, Jeong-Sook Seo, Han-Young Jin, Jae-Sik Jang, Tae-Hyun Yang, Dong-Soo Kim, So-Young Jeong, Yun Seok Song, Dong-Kie Kim, Pil-Sang Song, Sang-Hoon Seol, Doo-Il Kim
BACKGROUND AND OBJECTIVES: The earliest atrial (A)/ventricular (V) activation potential, or accessory pathway (AP) potential are commonly used as ablation targets for atrioventricular (AV) APs. However, these targets are sometimes ambiguous. SUBJECTS AND METHODS: We reviewed 119 catheter ablation cases in 112 patients diagnosed with orthodromic atrioventricular reentrant tachycardia (AVRT) or Wolff-Parkinson-White (WPW) syndrome. Local A/V amplitude potentials with the earliest activation or AP potential were measured shortly before achieving antegrade AP conduction block, ventriculoatrial block during right ventricle (RV) pacing, or AVRT termination with no AP conduction...
July 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/28765088/the-evolving-role-of-ankyrin-b-in-cardiovascular-disease
#9
Sara N Koenig, Peter J Mohler
Over the past decade, ankyrin-B has been identified as a prominent player in cardiac physiology. Ankyrin-B has a multitude of functions, with roles in expression, localization, and regulation of proteins critical for cardiac excitability, cytoskeletal integrity, and signaling. Furthermore, human ANK2 variants that result in ankyrin-B loss of function are associated with "ankyrin-B syndrome," a complex cardiac phenotype that may include bradycardia and heart rate variability, conduction block, atrial fibrillation, QT interval prolongation, and potentially fatal catecholaminergic polymorphic ventricular tachycardia...
July 29, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28712176/ecg-abnormalities-in-patients-with-chronic-kidney-disease
#10
Salman Shafi, Mohammad Saleem, Roshina Anjum, Wajid Abdullah, Tahir Shafi
BACKGROUND: Chronic kidney disease (CKD) is associated with increased risk of cardiovascular disease. Electrocardiographic (ECG) abnormalities are common in CKD patients. However, there is variation in literature regarding frequency of ECG abnormalities in CKD patients and limited information in local population. METHODS: The study design was cross-sectional in nature. All patients between ages of 20-80 years with CKD not previously on renal replacement therapy who were admitted to nephrology ward at a tertiary care facility over a 6-month period were included...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28705106/characteristic-features-of-patients-with-multiple-accessory-pathways
#11
Michal Orczykowski, Pawel Derejko, Piotr Urbanek, Robert Bodalski, Joanna Zakrzewska-Koperska, Maria Bilińska, Lukasz Szumowski
Objective Only limited clinical and electrophysiological data concerning patients (pts) with multiple accessory pathways (MAP) in comparison to large control groups are available. The aim of our study was to analyse these data from the largest cohort of patients with multiple accessory pathways and a large control group. Method and results We analysed data from pts with MAP (group 1) and pts with a single accessory pathway (AP) (group 2) referred for radiofrequency catheter ablation (RFCA) at our tertiary centre...
August 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28616546/late-gadolinium-enhancement-does-occur-in-tako-tsubo-cardiomyopathy-a-quantitative-cardiac-magnetic-resonance-and-speckle-tracking-strain-study
#12
Niranjan Gaikwad, Thomas Butler, Ryan Maxwell, Elizabeth Shaw, Wendy E Strugnell, Jonathan Chan, Gemma A Figtree, Richard E Slaughter, Christian Hamilton-Craig
BACKGROUND: Late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMR) has been recommended to distinguish Tako-tsubo cardiomyopathy (TTC) from either acute myocardial infarction or myocarditis. METHOD: 44 consecutive patients with confirmed Mayo Clinic criteria for TTC underwent CMR imaging at 1.5 Tesla during the acute phase. 10 patients who had CMRI to exclude scar related ventricular tachycardia, and had negative studies, were used as negative controls...
September 2016: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/28579601/efficacy-of-intensive-radiofrequency-energy-delivery-to-the-localized-dense-scar-area-in-post-infarction-ventricular-tachycardia-ablation%C3%A3-a-comparative-study-with-standard-strategy-targeting-the-infarcted-border-zone
#13
Kenji Kuroki, Akihiko Nogami, Kentaro Yoshida, Masahiko Goya, Masato Fukunaga, Kazuaki Kaitani, Naoaki Onishi, Takanao Mine, Takashi Koyama, Masayuki Igawa, Takeshi Machino, Hiro Yamasaki, Dongzhu Xu, Miyako Igarashi, Nobuyuki Murakoshi, Yukio Sekiguchi, Kazutaka Aonuma
BACKGROUND: Several reports have demonstrated the importance of severely low voltage areas as arrhythmogenic substrates of ventricular tachycardia (VT). However, a comparative study of dense scar-targeted and infarcted border zone-targeted strategies has not been reported.Methods and Results:We divided 109 consecutive patients with VT post-infarction from 6 centers into 2 groups according to the ablation strategy used: dense scar-targeted ablation (DS ablation, 48%) or border zone-targeted ablation (BZ ablation, 52%)...
June 3, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28576833/spinal-cord-stimulation-reduces-ventricular-arrhythmias-during-acute-ischemia-by-attenuation-of-regional-myocardial-excitability
#14
Kimberly Howard-Quijano, Tatsuo Takamiya, Erica A Dale, Jasmine Kipke, Yukiko Kubo, Tristan Grogan, Andyshea Afyouni, Kalyanam Shivkumar, Aman Mahajan
Myocardial ischemia creates autonomic nervous system imbalance and can trigger cardiac arrhythmias. We hypothesized that neuromodulation by spinal cord stimulation (SCS) will attenuate local cardiac sympathoexcitation from ischemia-induced increases in afferent signaling, reduce ventricular arrhythmias, and improve myocardial function during acute ischemia. Yorkshire pigs (n = 20) were randomized to SCS (50 Hz at 200-μs duration, current 90% motor threshold) or sham operation (sham) for 30 min before ischemia...
August 1, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28575318/early-versus-late-pulmonary-valve-replacement-in-patients-with-transannular-patch-repaired-tetralogy-of-fallot
#15
Bieke Dobbels, Marie-Christine Herregods, Els Troost, Alexander Van De Bruaene, Filip Rega, Werner Budts, Pieter De Meester
OBJECTIVES: Although the effects of pulmonary regurgitation after tetralogy of Fallot repair are detrimental, timing of pulmonary valve replacement (PVR) is unclear. Our goal was to evaluate the midterm efficacy and safety of early PVR. METHODS: Patients with tetralogy of Fallot who underwent repair from 1962 to 2015 were included from the local database. Statistical analyses compared patients who underwent early PVR (age ≤16 years), late PVR and no PVR. The timing of the intervention was compared for efficacy-all-cause mortality and the combined end-point of all-cause mortality, ventricular tachycardia and defibrillator implantation-and for safety-the combined end-point of 1-year postoperative mortality after PVR, endocarditis and reintervention...
September 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28534205/outflow-tract-ventricular-arrhythmias-electrocardiographic-features-in-relation-to-mapping-and-ablation
#16
REVIEW
Deepak Padmanabhan, Alan Sugrue, Prakriti Gaba, Samuel J Asirvatham
Ventricular arrhythmia arising from the outflow tracts can manifest itself as frequent premature ventricular complexes (PVCs), salvos of ventricular tachycardia (VT), and/or sustained VT. It is amenable to management with medication and catheter ablation without need for an intracardiac defibrillator. The electrocardiogram (ECG) is a crucial tool in the management of these patients as it is can help localize the site of origin, thereby helping guide the electrophysiologist. An appreciation of the unique anatomy of the outflow tracts as well as their relationships with the surrounding structures is essential in interpreting the ECG...
June 2017: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/28506576/-clinical-characteristics-and-follow-up-of-patients-with-magnetic-resonance-imaging-confirmed-myopericarditis-a-retrospective-study
#17
Q de Hemptinne, F Picard, V Spagnoli, M Renard
INTRODUCTION: Pericarditis are frequently associated with some degree of concomitant myocardial involvement. Predominant pericarditis with limited myocardial involvement are named myopericarditis. Data regarding myopericarditis are scarce. PATIENTS AND METHODS: Retrospective chart review of all patients admitted between 2002 and 2011 with magnetic resonance imaging confirmed myopericarditis. RESULTS: Twenty-seven patients were included. Eighty-one percent were men, with median age of 32 years...
May 12, 2017: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/28500178/electrical-substrate-elimination-in-135-consecutive-patients-with-brugada-syndrome
#18
Carlo Pappone, Josep Brugada, Gabriele Vicedomini, Giuseppe Ciconte, Francesco Manguso, Massimo Saviano, Raffaele Vitale, Amarild Cuko, Luigi Giannelli, Zarko Calovic, Manuel Conti, Paolo Pozzi, Andrea Natalizia, Simonetta Crisà, Valeria Borrelli, Ramon Brugada, Georgia Sarquella-Brugada, Marco Guazzi, Alessandro Frigiola, Lorenzo Menicanti, Vincenzo Santinelli
BACKGROUND: There is emerging evidence that localization and elimination of abnormal electric activity in the epicardial right ventricular outflow tract may be beneficial in patients with Brugada syndrome. METHODS AND RESULTS: A total of 135 symptomatic Brugada syndrome patients having implantable cardiac defibrillator were enrolled: 63 (group 1) having documented ventricular tachycardia (VT)/ventricular fibrillation (VF) and Brugada syndrome-related symptoms, and 72 (group 2) having inducible VT/VF without ECG documentation at the time of symptoms...
May 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28484842/conventional-mapping-and-ablation-of-focal-ventricular-tachycardias-in-the-healthy-heart
#19
REVIEW
Sonia Busch, Johannes Brachmann, Ahmed Saleh, Mathias Forkmann
Ventricular tachycardias (VT) in the healthy heart, also known as idiopathic VTs, often have a focal origin. Triggered activity due to delayed after-depolarization is the most likely mechanism of focal VTs. Localization of the site of origin of focal VTs is based on activation mapping with or without combination with pace mapping. The characteristic anatomic site of origin of idiopathic VTs is the right and left outflow tract. Other sites include the tricuspid and mitral annulus, the papillary muscles, and Purkinje fibers...
June 2017: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/28395022/optogenetic-manipulation-of-anatomical-re-entry-by-light-guided-generation-of-a-reversible-local-conduction-block
#20
Masaya Watanabe, Iolanda Feola, Rupamanjari Majumder, Wanchana Jangsangthong, Alexander S Teplenin, Dirk L Ypey, Martin J Schalij, Katja Zeppenfeld, Antoine A F de Vries, Daniël A Pijnappels
Aims: Anatomical re-entry is an important mechanism of ventricular tachycardia, characterized by circular electrical propagation in a fixed pathway. It's current investigative and therapeutic approaches are non-biological, rather unspecific (drugs), traumatizing (electrical shocks), or irreversible (ablation). Optogenetics is a new biological technique that allows reversible modulation of electrical function with unmatched spatiotemporal precision using light-gated ion channels. We therefore investigated optogenetic manipulation of anatomical re-entry in ventricular cardiac tissue...
March 1, 2017: Cardiovascular Research
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