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Alicia Cervantes-Elizarrarás, Javier Piloni-Martini, Esther Ramírez-Moreno, Ernesto Alanís-García, Norma Güemes-Vera, Carlos Alberto Gómez-Aldapa, Quinatzin Yadira Zafra-Rojas, Nelly Del Socorro Cruz-Cansino
The purpose of this research was to optimize the thermoultrasound conditions for blackberry juice using the response surface methodology and considering juice quality parameters and antioxidant capacity. With the exception of microbial growth, the response variables showed high correlation coefficients with the mathematical model (R(2)adj>0.91). Thermoultrasound treatment inactivated all the evaluated microorganisms, and at the optimum conditions (50±1°C at 17±1min) it increased enzyme inactivation and antioxidant activity in comparison to pasteurized juice...
January 2017: Ultrasonics Sonochemistry
Ummara Butt, Amr ElShaer, Lori A S Snyder, Athina Chaidemenou, Raid G Alany
Fatty acids (FAs) are used by many organisms as defence mechanism against virulent bacteria. The high safety profile and broad spectrum of activity make them potential alternatives to currently used topical antibiotics for the treatment of eye infections in neonates. The current study utilised a Design of Experiment approach to optimise the quantification of five fatty acids namely; lauric acid, tridecanoic acid, myristoleic acid, palmitoleic acid and α-linolenic acid. The significance of the influence of the experimental parameters such as volume of catalyst, volume of n-hexane, incubation temperature, incubation time and the number of extraction steps on derivatisation was established by statistical screening with a factorial approach...
October 20, 2016: Drug Delivery and Translational Research
Marisol Martínez-Alanis, Silvia Ruiz-Velasco, Claudia Lerma
BACKGROUND: Most approaches to predict ventricular tachyarrhythmias which are based on RR intervals consider only sinus beats, excluding premature ventricular complexes (PVCs). The method known as heartprint, which analyses PVCs and their characteristics, has prognostic value for fatal arrhythmias on long recordings of RR intervals (>70,000 beats). OBJECTIVE: To evaluate characteristics of PVCs from short term recordings (around 1000 beats) and their prognostic value for imminent sustained tachyarrhythmia...
October 3, 2016: International Journal of Cardiology
N A Wijetunga, M Pascual, J Tozour, F Delahaye, M Alani, M Adeyeye, A W Wolkoff, A Verma, J M Greally
The predisposition of patients with Hepatitis C virus (HCV) infection to hepatocellular carcinoma (HCC) involves components of viral infection, inflammation and time. The development of multifocal, genetically distinct tumours is suggestive of a field defect affecting the entire liver. The molecular susceptibility mediating such a field defect is not understood. One potential mediator of long-term cellular reprogramming is heritable (epigenetic) regulation of transcription, exemplified by DNA methylation. We studied epigenetic and transcriptional changes in HCV-infected livers in comparison with control, uninfected livers and HCC, allowing us to identify pre-neoplastic epigenetic and transcriptional events...
October 10, 2016: Oncogene
A Alani, M Kelleher
The complications of elective orthodontic treatment are numerous. Patients need to be aware, in advance, of possible problems including resorption, instability, caries, recession and failure to deliver optimal tooth position. The investment of time and resources by all concerned is considerable and if there are adverse outcomes these can be biologically costly in the longer term. A frank and full discussion of the possible problems is necessary following the findings of Montgomery vs. Lanarkshire in 2015.
October 7, 2016: British Dental Journal
Mónica Terán-Hernández, Rebeca Ramis-Prieto, Jaqueline Calderón-Hernández, Carlos Félix Garrocho-Rangel, Juan Campos-Alanís, José Antonio Ávalos-Lozano, Miguel Aguilar-Robledo
BACKGROUND: Worldwide, Cervical Cancer (CC) is the fourth most common type of cancer and cause of death in women. It is a significant public health problem, especially in low and middle-income/Gross Domestic Product (GDP) countries. In the past decade, several studies of CC have been published, that identify the main modifiable and non-modifiable CC risk factors for Mexican women. However, there are no studies that attempt to explain the residual spatial variation in CC incidence In Mexico, i...
September 29, 2016: International Journal for Equity in Health
D L Sepúlveda, J E Silva, A Gil, M Alanis, L F Garcia
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
Bosede B Afolabi, Olajumoke O Oladipo, Alani S Akanmu, Olalekan O Abudu, Olusoga A Sofola, Fiona Broughton Pipkin
BACKGROUND: Sickle cell disease (haemoglobin SS (HbSS)) mainly affects those of West African origin and is associated with hypervolaemia. Plasma volume rises by up to 50% in normal pregnancy but was previously found to be paradoxically contracted in late sickle cell pregnancy. The renin-angiotensin-aldosterone system is activated very early in human pregnancy to support the plasma volume expansion. We hypothesised that activation of the renin-angiotensin-aldosterone system would be blunted in pregnant women with sickle cell disease...
July 2016: Journal of the Renin-angiotensin-aldosterone System: JRAAS
S Alani, A Schlocker, N Honig, B W Corn
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
O R Treviño-Montemayor, M D Alanis-Beltran, D Saldivar-Rodriguez, A Guzman, J A Soria-Lopez, C Flores Acosta, F Hernandez-Castro, G Treviño, G Villagomez Martinez, L Cano-Hinojosa
No abstract text is available yet for this article.
September 2016: Ultrasound in Obstetrics & Gynecology
Julio C Salas-Alanís, Claire A Scott, Oscar R Fajardo-Ramírez, Carola Duran, María G Moreno-Treviño, David P Kelsell
GAPO syndrome is a very rare genetic disorder characterized by growth retardation, alopecia, pseudoanodontia and progressive optic atrophy (GAPO). To date, only 30 cases have been described worldwide. Recently, gene alterations in the ANTXR1 gene have been reported to be causative of this disorder, and an autosomal recessive pattern has been observed. This gene encodes a matrix-interacting protein that works as an adhesion molecule. In this report, we describe 2 homozygous siblings diagnosed with GAPO syndrome carrying a new missense mutation...
July 2016: Molecular Syndromology
Ujani Chakraborty, Eric Alani
Mismatch repair (MMR) systems correct DNA mismatches that result from DNA polymerase misincorporation errors. Mismatches also appear in heteroduplex DNA intermediates formed during recombination between nearly identical sequences, and can be corrected by MMR or removed through an unwinding mechanism, known as anti-recombination or heteroduplex rejection. We review studies, primarily in baker's yeast, which support how specific factors can regulate the MMR/anti-recombination decision. Based on recent advances, we present models for how DNA structure, relative amounts of key repair proteins, the timely localization of repair proteins to DNA substrates, and epigenetic marks can modulate this critical decision...
August 28, 2016: FEMS Yeast Research
R Baños-Gómez, N S Cruz-Cansino, T Suarez-Diéguez, C Valadez-Vega, E Ramírez-Moreno, E Alanís-García, J A Ariza-Ortega, J J Manríquez-Torres, E Zamora-Romo, L Delgado-Olivares
Undernutrition induces an increase of the oxidative stress that can predispose offspring to various diseases in adulthood through epigenetic reprogramming. The aim of this study was to evaluate the effects of intergenerational undernutrition on protein oxidation and antioxidant defence response on liver, heart and brain of the second-generation neonates (F2 ) of undernourished rats. For this purpose, both parents in parental (F0 ) and first generation (F1 ) were fed with a low-nutrient diet. Body mass and length decreased (p < 0...
August 26, 2016: Journal of Animal Physiology and Animal Nutrition
Sabrina Alani, Holly Black, Chris Harty, Justin Murphy, Desmond Whalen, Kerry-Lynn Williams
The Royal College CanMEDS framework has become a guide for medical school curricula. This framework aims to improve patient care by identifying and explaining seven key roles that physicians must fulfill in order to deliver high-quality healthcare to their patients. While medical schools incorporate these roles in their teaching processes, students can also apply them outside the classroom. Here, we describe a unique model developed at Memorial University of Newfoundland's Tuckamore Simulation Research Collaborative (TSRC), where students develop simulation cases with the guidance of expert mentors and apply the Royal College CanMEDS framework to writing clinical simulations...
2016: Curēus
Colleen R Kelly, Alexander Khoruts, Christopher Staley, Michael J Sadowsky, Mortadha Abd, Mustafa Alani, Brianna Bakow, Patrizia Curran, Joyce McKenney, Allison Tisch, Steven E Reinert, Jason T Machan, Lawrence J Brandt
Background: To date, evidence for the efficacy of fecal microbiota transplantation (FMT) in recurrent Clostridium difficile infection (CDI) has been limited to case series and open-label clinical trials. Objective: To determine the efficacy and safety of FMT for treatment of recurrent CDI. Design: Randomized, controlled, double-blind clinical trial. ( NCT01703494). Setting: Two academic medical centers...
August 23, 2016: Annals of Internal Medicine
David Neder-Suárez, Carlos A Amaya-Guerra, Armando Quintero-Ramos, Esther Pérez-Carrillo, María G de J Alanís-Guzmán, Juan G Báez-González, Carlos L García-Díaz, María A Núñez-González, Daniel Lardizábal-Gutiérrez, Jorge A Jiménez-Castro
Effects of extrusion cooking and low-temperature storage on the physicochemical changes and resistant starch (RS) content in cornstarch were evaluated. The cornstarch was conditioned at 20%-40% moisture contents and extruded in the range 90-130 °C and at screw speeds in the range 200-360 rpm. The extrudates were stored at 4 °C for 120 h and then at room temperature. The water absorption, solubility index, RS content, viscoelastic, thermal, and microstructural properties of the extrudates were evaluated before and after storage...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Manhal Izzy, Ghalib Jibara, Aws Aljanabi, Mustafa Alani, Emily Giannattasio, Hina Zaidi, Zaid Said, Paul Gaglio, Allan Wolkoff, John F Reinus
BACKGROUND: Individuals ineligible for interferon-based hepatitis C therapy may have a worse prognosis than patients who have failed or not received treatment. AIMS: To provide information about the limitations of medical treatment of hepatitis C in real-world patients. METHODS: We studied 969 treatment-ineligible patients and 403 treated patients enrolled between 1/1/01 and 6/30/06; data were collected until 3/31/13. Treatment barriers were grouped into five categories and classified as health-related or health-unrelated...
June 2016: Journal of Clinical and Experimental Hepatology
Jon Mallen-St Clair, Mustafa Alani, Marilene B Wang, Eri S Srivatsan
The last decade has brought about an unexpected rise in oropharyngeal squamous cell carcinoma (OPSCC) primarily in white males from the ages of 40-55years, with limited exposure to alcohol and tobacco. This subset of squamous cell carcinoma (SCC) has been found to be associated with human papillomavirus infection (HPV). Other Head and Neck Squamous Cell carcinoma (HNSCC) subtypes include oral cavity, hypopharyngeal, nasopharyngeal, and laryngeal SCC which tend to be HPV negative. HPV associated oropharyngeal cancer has proven to differ from alcohol and tobacco associated oropharyngeal carcinoma in regards to the molecular pathophysiology, presentation, epidemiology, prognosis, and improved response to chemoradiation therapy...
July 31, 2016: Biochimica et Biophysica Acta
Viviane da Silva Kagy, Luciana Trevisan Bittencourt Muniz, Arieli Carini Michels, Suelen Teixeira Luiz, Luciana Reis Azevedo Alanis, João Armando Brancher, Ana Maria Trindade Grégio, Sérgio Aparecido Ignácio, Elisa Souza Camargo, Maria Ângela Naval Machado, Aline Cristina Batista Rodrigues Johann
Patients who seek dental treatment may have bipolar disorder, and lithium carbonate (LC) is the drug of choice used in the treatment of this disorder. Taking into consideration the controversial results found in the literature, and the possible influence of LC on induced tooth movement, the objective was to evaluate tooth movement induced in rats after administration of lithium carbonate. One hundred and ninety-two rats were divided into 3 groups. In the L group, the animals received daily 60mg/kg of LC, they were not subjected to orthodontic movement, and they were euthanized after 33, 37, 44 or 51 days...
2016: PloS One
Rhoda M Alani, Allison Larson, Vincent Falanga
No abstract text is available yet for this article.
August 2016: Academic Medicine: Journal of the Association of American Medical Colleges
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