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https://www.readbyqxmd.com/read/28633591/approaches-in-topical-ocular-drug-delivery-and-developments-in-the-use-of-contact-lenses-as-drug-delivery-devices
#1
Prina Mehta, Rita Haj-Ahmad, Ali Al-Kinani, Muhammad Sohail Arshad, Ming-Wei Chang, Raid G Alany, Zeeshan Ahmad
Drug-delivery approaches have diversified over the last two decades with the emergence of nanotechnologies, smart polymeric systems and multimodal functionalities. The intended target for specific treatment of disease is the key defining developing parameter. One such area which has undergone significant advancements relates to ocular delivery. This has been expedited by the development of material advancement, mechanistic concepts and through the deployment of advanced process technologies. This review will focus on the developments within lens-based drug delivery while touching on conventional and current methods of topical ocular drug delivery...
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28625688/electrically-atomised-formulations-of-timolol-maleate-for-direct-and-on-demand-ocular-lens-coatings
#2
Prina Mehta, Ali Al-Kinani, Rita Haj-Ahmad, Muhammad Sohail Arshad, Ming-Wei Chang, G Raid Alany, Zeeshan Ahmad
Advances in nanotechnology have enabled solutions for challenging drug delivery targets. While the eye presents numerous emerging opportunities for delivery, analysis and sensing; issues persist for conventional applications. This includes liquid phase formulation localisation on the ocular surface once administered as formulated eye-drops; with the vast majority of dosage (>90%) escaping from the administered site due to tear production and various drainage mechanisms. The work presented here demonstrates a single needle electrohydrodynamic (EHD) engineering process to nano-coat (as an on demand and controllable fiber depositing method) the surface of multiple contact lenses rendering formulations to be stationary on the lens and at the bio-interface...
June 15, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28618035/population-pharmacokinetics-of-imatinib-in-nigerians-with-chronic-myeloid-leukemia-clinical-implications-for-dosing-and-resistance
#3
Babatunde Ayodeji Adeagbo, Tiwalade Adewale Olugbade, Muheez Alani Durosinmi, Rahman Ayodele Bolarinwa, Kayode Ogungbenro, Oluseye Oladotun Bolaji
Imatinib, a tyrosine kinase inhibitor, is the drug of choice for the treatment of chronic myeloid leukemia in Nigeria. Several studies have established interindividual and interpopulation variations in imatinib disposition although no pharmacokinetic study have been conducted in an African population since the introduction of the drug. This study explored a population pharmacokinetic approach to investigate the disposition of imatinib in Nigerians and examined the involvement of some covariates including genetic factors in the variability of the drug disposition with a view to optimize the use of the drug in this population...
June 15, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28604646/effect-of-supercritical-carbon-dioxide-extraction-parameters-on-the-biological-activities-and-metabolites-present-in-extracts-from-arthrospira-platensis
#4
Diego A Esquivel-Hernández, José Rodríguez-Rodríguez, Sara P Cuéllar-Bermúdez, J Saúl García-Pérez, Elena I Mancera-Andrade, Jade E Núñez-Echevarría, Aura Ontiveros-Valencia, Magdalena Rostro-Alanis, Rebeca M García-García, J Antonio Torres, Wei Ning Chen, Roberto Parra-Saldívar
Arthrospira platensis was used to obtain functional extracts through supercritical carbon dioxide extraction (SFE-CO₂). Pressure (P), temperature (T), co-solvent (CX), static extraction (SX), dispersant (Di) and dynamic extraction (DX) were evaluated as process parameters through a Plackett-Burman design. The maximum extract yield obtained was 7.48 ± 0.15% w/w. The maximum contents of bioactive metabolites in extracts were 0.69 ± 0.09 µg/g of riboflavin, 5.49 ± 0.10 µg/g of α-tocopherol, 524.46 ± 0...
June 12, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28603107/anti-fungal-and-anti-mycobacterial-activity-of-plants-of-nuevo-leon-mexico
#5
Blanca Alicia Alanis Garza, Joel López Arroyo, Gloria González González, Elvira Garza González, Elvira Garza González, Noemí Waksman de Torres, Ricardo Salazar Aranda
Severe fungal infections, particularly those caused by Candida spp, have increased in recent decades and are associated with an extremely high rate of morbidity and mortality. Since plants are an important source of potentially bioactive compounds, in this work the antifungal activity of the methanol extracts of 10 plants (Acacia rigidula, Buddleja cordata, Cephalanthus occidentalis, Juglans nigra, Parkinsonia aculeata, Parthenium hysterophorus, Quercus canbyi, Ricinus communis, Salvia coccinea and Teucrium bicolor) were evaluated...
January 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28603066/differential-gene-expression-profiles-according-to-the-iaslc-ats-ers-histopathological-classification-in-lung-adenocarcinoma-subtypes
#6
Camilo Molina-Romero, Claudia Rangel-Escareño, Alette Ortega-Gómez, Gerardo J Alanis-Funes, Alejandro Aviles-Salas, Federico Avila-Moreno, Gabriela E Mercado, Andres F Cardona, Alfredo Hidalgo-Miranda, Oscar Arrieta
The current lung cancer classification from the Association for the Study of Lung Cancer (IASLC) / the American Thoracic Society (ATS)/ the European Respiratory Society (ERS) has considerably changed the pathologic diagnosis of lung invasive adenocarcinoma, identifying disease subtypes with substantial implications for medical practice, such as clinical, radiological, molecular and prognostic differences. We analyzed the differences in the genetic expression of adenocarcinoma subtypes according to the new classification...
June 8, 2017: Human Pathology
https://www.readbyqxmd.com/read/28586647/phosphate-starvation-dependent-iron-mobilization-induces-cle14-expression-to-trigger-root-meristem-differentiation-through-clv2-pepr2-signaling
#7
Dolores Gutiérrez-Alanís, Lenin Yong-Villalobos, Pedro Jiménez-Sandoval, Fulgencio Alatorre-Cobos, Araceli Oropeza-Aburto, Javier Mora-Macías, Federico Sánchez-Rodríguez, Alfredo Cruz-Ramírez, Luis Herrera-Estrella
Low inorganic phosphate (Pi) availability causes terminal differentiation of the root apical meristem (RAM), a phenomenon known as root meristem exhaustion or determined growth. Here, we report that the CLE14 peptide acts as a key player in this process. Low Pi stress induces iron mobilization in the RAM through the action of LPR1/LPR2, causing expression of CLE14 in the proximal meristem region. CLV2 and PEPR2 receptors perceive CLE14 and trigger RAM differentiation, with concomitant downregulation of SHR/SCR and PIN/AUXIN pathway...
June 5, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28570877/quinone-functionalized-activated-carbon-improves-the-reduction-of-congo-red-coupled-to-the-removal-of-p-cresol-in-a-uasb-reactor
#8
Luis H Alvarez, Iris C Arvizu, Refugio Bernardo García-Reyes, Claudia M Martinez, Daniel Olivo-Alanis, Yair A Del Angel
In this research was immobilized anthraquinone-2-sulfonate (AQS) on granular activated carbon (GAC) to evaluate its capacity to reduce congo red (CR) in batch reactor and continuous UASB reactors. The removal of p-cresol coupled to the reduction of CR was also evaluated. Results show that the immobilization of AQS on GAC (GAC-AQS) achieved 0.469mmol/g, improving 2.85-times the electron-transferring capacity compared to unmodified GAC. In batch, incubations with GAC-AQS achieved a rate of decolorization of 2...
May 19, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28550931/usefulness-of-the-mitral-regurgitation-severity-index-to-assess-the-severity-of-chronic-mitral-regurgitation
#9
Luis Afonso, Mohamed Shokr, Emmanuel Akintoye, Alexandros Briasoulis, Issa Alesh, Anas Alani, Nitin Mahajan, Vikas Veeranna, Ashraf Mostafa, Hammam Zmily, Tesfaye Telila, Sandip Zalawadiya
Existing metrics for grading mitral regurgitation (MR) are limited and fraught with high interobserver variability. We developed and evaluated a Doppler-based, semiquantitative novel index (Mitral Regurgitation Severity Index [MRSI]) of MR severity. In a total of 125 patients (70 in the derivation cohort and 55 in the validation cohort), MRSI was calculated as a ratio of time velocity integral of mitral inflow (continuous-wave Doppler-TVI MV) to the time velocity integral of the left ventricle outflow (pulse-wave Doppler-TVI LVOT)...
July 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28533419/dna-replication-and-mismatch-repair-safeguard-against-metabolic-imbalances
#10
Carol M Manhart, Eric Alani
No abstract text is available yet for this article.
May 30, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28525650/detection-of-damage-on-single-or-double-stranded-dna-in-a-population-exposed-to-arsenic-in-drinking-water
#11
J Jiménez-Villarreal, D I Rivas-Armendariz, C P Pineda-Belmontes, N D Betancourt-Martínez, M A Macías-Corral, A J Guerra-Alanis, M S Niño-Castañeda, J Morán-Martínez
Different studies have suggested an association between arsenic (As) exposure and damage to single-stranded DNA by reactive oxygen species derived from the biotransformation of arsenic. The single strand damages are converted to double strand damage upon interaction with ultraviolet radiation. Analysis of genomic integrity is important for assessing the genotoxicity caused by environmental pollutants. In this study, we compared the concentration of As in drinking water, nutritional status, lifestyle variables, and the level of genotoxicity in an exposed population and a control group...
May 18, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28516220/prevalence-and-factors-associated-with-supportive-care-needs-among-newly-diagnosed-mexican-breast-cancer-patients
#12
Adriana Pérez-Fortis, Joke Fleer, Juan José Sánchez-Sosa, María Guadalupe Veloz-Martínez, Patricia Alanís-López, Maya J Schroevers, Adelita V Ranchor
PURPOSE: Mexican breast cancer patients are generally diagnosed in advanced stages of the disease and often experience delays in cancer treatment delivery. Currently, little is known about these patients' psychological care needs. This study assessed levels and correlates of supportive care needs of Mexican breast cancer patients around the time of cancer diagnosis. METHODS: One hundred seventy-three newly diagnosed Mexican breast cancer patients participated in the study...
May 17, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28492805/first-record-of-craspedacusta-sowerbii-lankester-1880-hydrozoa-limnomedusae-in-a-natural-freshwater-lagoon-of-uruguay-with-notes-on-polyp-stage-in-captivity
#13
M G Failla Siquier, W S Serra Alanis, C Martinez Debat
The freshwater cnidarian Craspedacusta sowerbii Lankester 1880, has invaded lakes and ponds as well as artificial water bodies throughout the world. The first record in Uruguay corresponding to the jellyfish was made in 1961 in two artificial fountains, with no mention of the polyp form. Although local reports of other related polyp species have been made, information on the benthic form of C. sowerbii is lacking. Here we report the finding of live frustules, solitary individuals, medusae and colonies from a natural lagoon in August 2010, allowing us to observe the morphology and behavior of the polyp stage in captivity...
May 4, 2017: Brazilian Journal of Biology, Revista Brasleira de Biologia
https://www.readbyqxmd.com/read/28464959/temporal-genetic-changes-in-plasmodium-vivax-apical-membrane-antigen-1-over-19%C3%A2-years-of-transmission-in-southern-mexico
#14
Alejandro Flores-Alanis, Lilia González-Cerón, Frida Santillán, Cecilia Ximenez, Marco A Sandoval, René Cerritos
BACKGROUND: Mexico advanced to the pre-elimination phase in 2009 due to a significant reduction in malaria cases, and since 2000, Plasmodium vivax is the only species transmitted. During the last two decades, malaria transmission has been mostly local and isolated to a few regions. It is important to gain further insights into the impact of control measures on the parasite population structure. Hence, the aim of the current study was to determine detailed changes in P. vivax genetic diversity and population structure based on analysing the gene that encodes the apical membrane antigen 1 (pvama1)...
May 2, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28453523/the-mismatch-repair-and-meiotic-recombination-endonuclease-mlh1-mlh3-is-activated-by-polymer-formation-and-can-cleave-dna-substrates-in-trans
#15
Carol M Manhart, Xiaodan Ni, Martin A White, Joaquin Ortega, Jennifer A Surtees, Eric Alani
Crossing over between homologs is initiated in meiotic prophase by the formation of DNA double-strand breaks that occur throughout the genome. In the major interference-responsive crossover pathway in baker's yeast, these breaks are resected to form 3' single-strand tails that participate in a homology search, ultimately forming double Holliday junctions (dHJs) that primarily include both homologs. These dHJs are resolved by endonuclease activity to form exclusively crossovers, which are critical for proper homolog segregation in Meiosis I...
April 2017: PLoS Biology
https://www.readbyqxmd.com/read/28400510/malate-dependent-fe-accumulation-is-a-critical-checkpoint-in-the-root-developmental-response-to-low-phosphate
#16
Javier Mora-Macías, Jonathan Odilón Ojeda-Rivera, Dolores Gutiérrez-Alanís, Lenin Yong-Villalobos, Araceli Oropeza-Aburto, Javier Raya-González, Gabriel Jiménez-Domínguez, Gabriela Chávez-Calvillo, Rubén Rellán-Álvarez, Luis Herrera-Estrella
Low phosphate (Pi) availability constrains plant development and seed production in both natural and agricultural ecosystems. When Pi is scarce, modifications of root system architecture (RSA) enhance the soil exploration ability of the plant and lead to an increase in Pi uptake. In Arabidopsis, an iron-dependent mechanism reprograms primary root growth in response to low Pi availability. This program is activated upon contact of the root tip with low-Pi media and induces premature cell differentiation and the arrest of mitotic activity in the root apical meristem, resulting in a short-root phenotype...
April 25, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28392053/factors-affecting-cardiovascular-and-cerebrovascular-complications-of-carotid-artery-stenting-in-northern-michigan-a-retrospective-study
#17
Dalia F Mammo, Chin-I Cheng, Neli P Ragina, Firas Alani
BACKGROUND: This study seeks to identify factors associated with periprocedural complications of carotid artery stenting (CAS) to best understand CAS complication rates and optimize patient outcomes. Periprocedural complications include major adverse cardiovascular and cerebrovascular events (MACCE) that include myocardial infarction (MI), stroke, or death. METHODS: We retrospectively analyzed 181 patients from Northern Michigan who underwent CAS. Rates of stroke, MI, and death occurring within 30days post-procedure were examined...
March 24, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28361598/topical-and-transdermal-formulation-and-drug-delivery
#18
Raid Alany
No abstract text is available yet for this article.
June 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28351029/cytopathological-changes-induced-by-the-crack-use-in-oral-mucosa
#19
Milena Binhame Albini, Ingra Taís Malacarne, Thiago Beltrami Dias Batista, Antônio Adilson Soares de Lima, Maria Angela Naval Machado, Aline Cristina Batista Rodrigues Johann, Edvaldo Antonio Ribeiro Rosa, Luciana Reis Azevedo-Alanis
AIMS: To evaluate cytological alterations, inflammation, and microbial charge of the oral mucosa epithelium in crack users in in terms of the amount and duration of use. METHODS: Two hundred thirty four crack users (case group) and 120 non-users (control group) participated in this study. Clinically healthy epithelial cells were collected from the posterior mouth floor, using the conventional exfoliative cytology. Some of the aspects evaluated were as follows: Papanicolaou classification, nuclear area (NA), cytoplasmic area (CA), nuclear/cytoplasmic area ratio (NA/CA), inflammation, microbial charge, keratinization, enucleated superficial cells, and binucleation...
2017: European Addiction Research
https://www.readbyqxmd.com/read/28343599/presence-characteristics-and-volumes-of-coronary-plaque-determined-by-computed-tomography-angiography-in-young-type-2-diabetes-mellitus
#20
Negin Nezarat, Matthew J Budoff, Yanting Luo, Sirous Darabian, Rine Nakanishi, Dong Li, Nasim Sheidaee, Michael Kim, Anas Alani, Suguru Matsumoto, Sina Rahmani, Mitsuru Kanisawa, Indre Ceponiene, Kazuhiro Osawa, Hong Qi, Sajad Hamal, Pieter Kitslaar, Alexander Broersen, Ferdinand Flores, Eli Ipp, Bahram Khazai
Prevention and management of coronary artery disease (CAD) is of great concern in patients with diabetes mellitus. Although the impact of coronary atherosclerosis is described well for subjects older than 40 years, the prevalence and types of coronary atherosclerosis in young patients are not well known. The aim of this study was to evaluate the prevalence, extent, severity, and volumes of coronary plaque in type 2 diabetes mellitus (T2DM) population younger than of 40 years. This prospective study enrolled 181 subjects (25-40 year old) undergoing coronary computed tomography angiography, with 86 T2DM and 95 nondiabetic age/gender-matched subjects...
March 1, 2017: American Journal of Cardiology
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