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https://www.readbyqxmd.com/read/29674443/recent-advances-in-the-treatment-of-peripheral-t-cell-lymphoma
#1
REVIEW
Kamel Laribi, Mustapha Alani, Catherine Truong, Alix Baugier de Materre
Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of clinically aggressive diseases associated with poor outcome. Despite progress in the last several years, resulting in a deeper understanding of the natural history and biology of PTCL based on molecular profiling and next-generation sequencing, there is a need for improvement in efficacy of chemotherapeutic regimens for newly diagnosed patients. Treatment in the front-line setting is most often cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) or CHOP-like regimens, which are associated with a high failure rate and frequent relapses...
April 19, 2018: Oncologist
https://www.readbyqxmd.com/read/29661663/right-on-target
#2
Omer M Farhan-Alanie, David F Howie, Jonathan O'Reilly, Jacqui MacNair
Targets have become an integral part of health care, whether we agree with them or not. Many accept the progress made with the use of targets, but our duty as health professionals is to ensure that their use and interpretation is undertaken with the same care and understanding of their limitations that we apply to our clinical practice, and that they are not mis-interpreted or used to justify the latest political idioms. Currently the healthcare profession is failing to understand the consequences of setting targets, or the wider implications of hitting them...
April 13, 2018: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/29576359/correlation-of-symptoms-to-serum-vitamin-d-levels
#3
Mir Sadat-Ali, Omar N Al Essa, Fawaz M Alani, Hussain K Al Omar, Walid Y Ebrahim
BACKGROUND AND OBJECTIVE: Recent studies have shown that vitamin D plays an important role in many disease processes. However, data is lacking which correlates the common symptoms attributed with vitamin D levels. This study was undertaken to find the correlation of symptoms and Vitamin D levels among ethnic Saudi Arabian population. METHODS: A structured questionnaire was made and translated in the Arabic language, which included, age, weight and height, ethnicity and marital status...
April 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29562319/improvements-in-modelling-bystander-and-resident-exposure-to-pesticide-spray-drift-investigations-into-new-approaches-for-characterizing-the-collection-efficiency-of-the-human-body
#4
M Clare Butler Ellis, Marc C Kennedy, Christian J Kuster, Rafael Alanis, Clive R Tuck
The BREAM (Bystander and Resident Exposure Assessment Model) (Kennedy et al. in BREAM: A probabilistic bystander and resident exposure assessment model of spray drift from an agricultural boom sprayer. Comput Electron Agric 2012;88:63-71) for bystander and resident exposure to spray drift from boom sprayers has recently been incorporated into the European Food Safety Authority (EFSA) guidance for determining non-dietary exposures of humans to plant protection products. The component of BREAM, which relates airborne spray concentrations to bystander and resident dermal exposure, has been reviewed to identify whether it is possible to improve this and its description of variability captured in the model...
March 17, 2018: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/29561205/significant-impact-of-immunosuppression-on-the-incidence-of-secondary-malignancies-following-fludarabine-cyclophosphamide-and-rituximab-fcr-treatment-in-patients-with-indolent-b-cell-neoplasms
#5
Nathalie Denizon, Alix Baugier de Materre, Mustapha Alani, Habib Ghnaya, Jonathan Farhi, Anne Besançon, Kamel Laribi
No abstract text is available yet for this article.
March 21, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29551123/bullosis-diabeticorum-a-neglected-bullous-dermatosis
#6
Ramya Vangipuram, Tiffany Hinojosa, Daniel J Lewis, Christopher Downing, Caleb Hixson, Julio César Salas-Alanis, Stephen K Tyring
A 75-year-old African-American man presented with a 3-year history of painless, fluid-filled blisters, for which his primary care physician had treated him with doxycycline, cephalexin, and topical corticosteroids, with no significant improvement. The blisters had ruptured spontaneously and healed with scarring. He denied antecedent trauma. His medical history was remarkable for insulin-dependent type 2 diabetes mellitus, hypertension, hypercholesterolemia, primary cutaneous melanoma status-post excision, and breast cancer status-post mastectomy and chemotherapy...
2018: Skinmed
https://www.readbyqxmd.com/read/29485939/circulation-of-highly-drug-resistant-clostridium-difficile-ribotypes-027-and-001-in-two-tertiary-care-hospitals-in-mexico
#7
Adrián Martínez-Meléndez, Laura Tijerina-Rodríguez, Rayo Morfin-Otero, Adrián Camacho-Ortíz, Licet Villarreal-Treviño, Hugo Sánchez-Alanís, Eduardo Rodríguez-Noriega, Simon D Baines, Samantha Flores-Treviño, Héctor Jesús Maldonado-Garza, Elvira Garza-González
OBJECTIVE: To assess drug susceptibility and characterize Clostridium difficile ribotypes in isolates from two tertiary-care hospitals in Mexico. METHODS: Isolates were evaluated for genotyping, antimicrobial susceptibility testing and detection of mutations associated with drug resistance. PCR ribotyping was performed using a combination of gel-based and capillary electrophoresis-based approaches. RESULTS: MIC50 and MIC90 were ≥128 mg/L for ciprofloxacin, erythromycin, clindamycin, and rifampicin...
February 27, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29473190/seven-novel-col7a1-mutations-identified-in-patients-with-recessive-dystrophic-epidermolysis-bullosa-from-mexico
#8
A H Saeidian, L Youssefian, M G Moreno Trevino, G Fortuna, H Vahidnezhad, V S Atanasova, J Uitto, J C Salas-Alanis, A P South
Recessive dystrophic epidermolysis bullosa (RDEB; OMIM #226600) is one of the most devastating subtypes of epidermolysis bullosa, a group of skin and mucous membrane blistering disorders often associated with extracutaneous manifestations. RDEB is caused by mutations in COL7A1, the gene encoding type VII collagen (C7), and to date over 700 different mutations in the 8835 nucleotides constituting the open reading frame or adjacent exon-intron boundaries of COL7A1 have been described. We used targeted next-generation sequencing to identify seven previously unreported mutations in a cohort of 17 Mexican patients who were diagnosed with RDEB based on clinical presentation and immunoepitope mapping...
February 23, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29411301/emerging-biomarkers-in-cutaneous-melanoma
#9
REVIEW
Anna Eisenstein, Estela Chen Gonzalez, Rekha Raghunathan, Xixi Xu, Muzhou Wu, Emily O McLean, Jean McGee, Byungwoo Ryu, Rhoda M Alani
Earlier identification of aggressive melanoma remains a goal in the field of melanoma research. With new targeted and immune therapies that have revolutionized the care of patients with melanoma, the ability to predict progression and monitor or predict response to therapy has become the new focus of research into biomarkers in melanoma. In this review, promising biomarkers are highlighted. These biomarkers have been used to diagnose melanoma as well as predict progression to advanced disease and response to therapy...
February 6, 2018: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/29386955/vitamin-d-deficiency-in-saudi-arabians-a-reality-or-simply-hype-a-meta-analysis-2008-2015
#10
REVIEW
Haneen Al-Alyani, Haifa A Al-Turki, Omar N Al-Essa, Fawaz M Alani, Mir Sadat-Ali
BACKGROUND AND OBJECTIVE: The objective of this systematic review was to determine from published data the prevalence of Vitamin D deficiency in the Saudi population. METHODS: An extensive and meticulous search was conducted for studies published in MEDLINE, EMBASE the Cochrane Central Register of Controlled Trials and Cochrane Database of Systematic Reviews (2008-2015), and the Science Citation Index published data from the Annals of Saudi Medicine and Saudi Medical Journal with the key words: Vitamin D deficiency, insufficiency, and Saudi Arabians...
January 2018: Journal of Family & Community Medicine
https://www.readbyqxmd.com/read/29382480/-association-between-homozygous-c-318a-gt-mutation-in-exon-2-of-the-eif2b5-gene-and-the-infantile-form-of-vanishing-white-matter-leukoencephalopathy
#11
Carmen Esmer, Gabriela Blanco Hernández, Víctor Saavedra Alanís, Jorge Guillermo Reyes Vaca, Antonio Bravo Oro
BACKGROUND: Vanishing white matter disease is one of the most frequent leukodystrophies in childhood with an autosomal recessive inheritance. A mutation in one of the genes encoding the five subunits of the eukaryotic initiation factor 2 (EIF2B5) is present in 90% of the cases. The diagnosis can be accomplished by the clinical and neuroradiological findings and molecular tests. CASE REPORT: We describe a thirteen-month-old male with previous normal neurodevelopment, who was hospitalized for vomiting, hyperthermia and irritability...
September 2017: Boletín Médico del Hospital Infantil de México
https://www.readbyqxmd.com/read/29368905/-the-aging-of-mexican-population
#12
Gerardo Rivera-Silva, Leonardo Rodríguez-Reyes, Ma Guadalupe Treviño-Alanís
No abstract.
November 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29363399/ocular-otic-nasal-rectal-and-vaginal-formulation-innovations-and-regulatory-considerations
#13
EDITORIAL
Raid Alany
No abstract text is available yet for this article.
March 2018: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/29353188/mechanism-of-anaerobic-bio-reduction-of-azo-dye-assisted-with-lawsone-immobilized-activated-carbon
#14
Daniel Olivo-Alanis, Refugio Bernardo Garcia-Reyes, Luis H Alvarez, Alcione Garcia-Gonzalez
Lawsone redox (LQ) mediator was covalently bound to granular activated carbon (GAC) by Fischer esterification. A high LQ adsorption capacity on GAC was achieved (∼230 mg/g), and desorption studies showed strong chemical stability. Furthermore, kinetic experiments with solid-phase redox mediator (RM) and their controls (soluble RM, GAC and anaerobic sludge) were tested for decolorization of congo red dye at initial concentration of 175 mg/L. Benzidine, a by-product of complete congo red reduction, was also measured by HPLC analysis along the kinetic experiments...
April 5, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29351260/fatty-acid-based-microemulsions-to-combat-ophthalmia-neonatorum-caused-by-neisseria-gonorrhoeae-and-staphylococcus-aureus
#15
Ummara Butt, Amr ElShaer, Lori A S Snyder, Ali A Al-Kinani, Adam Le Gresley, Raid G Alany
The bacterial species Neisseria gonorrhoeae ( N. gonorrhoeae ) and Staphylococcus aureus ( S. aureus ) are amongst the main microorganisms that cause ophthalmia neonatorum. The current treatment involves the use of various antibiotics such as ciprofloxacin, cephalosporin, ceftriaxone and cefotaxime. However, this treatment strategy is becoming more ineffective due to the antibiotic resistance in N. gonorrhoeae. The current study explores the potential use of fatty acid based microemulsions (ME) to prevent N...
January 19, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29344305/a-tumor-activatable-theranostic-nanomedicine-platform-for-nir-fluorescence-guided-surgery-and-combinatorial-phototherapy
#16
Xiaoning Li, Canan Schumann, Hassan A Albarqi, Christopher J Lee, Adam W G Alani, Shay Bracha, Milan Milovancev, Olena Taratula, Oleh Taratula
Fluorescence image-guided surgery combined with intraoperative therapeutic modalities has great potential for intraoperative detection of oncologic targets and eradication of unresectable cancer residues. Therefore, we have developed an activatable theranostic nanoplatform that can be used concurrently for two purposes: (1) tumor delineation with real-time near infrared (NIR) fluorescence signal during surgery, and (2) intraoperative targeted treatment to further eliminate unresected disease sites by non-toxic phototherapy...
2018: Theranostics
https://www.readbyqxmd.com/read/29340764/correction-to-population-data-of-21-autosomal-str-loci-in-the-hausa-igbo-and-yoruba-people-of-nigeria
#17
Victoria O Okolie, Selena Cisana, Moses S Schanfield, Alani Sulaimon Akanmu, Khalid O Adekoya, Olufemi A Oyedeji, Daniele Podini
In the original paper author Alani Sulaimon Akanmu was erroneously omitted from the author list. Prof. Akanmu has now been added as 4th author. Prof. Akanmu acted as an academic supervisor of the study and additionally contributed to the publication by reading, commenting and editing the manuscript.
January 16, 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29323717/chondrogenic-differentiation-of-human-scalp-adipose-derived-stem-cells-in-polycaprolactone-scafold-and-using-freeze-thaw-freeze-method
#18
Rana Moradian Tehrani, Hamed Mirzaie, Javad Verdi, Amirhossein Sahebkar, Mahdi Noureddini, Rasoul Salehi, Behrang Alani, Mojtaba Kianmehr
Human adipose tissue has been identified as a viable alternative source for mesenchymal stem cells. SADSCs were isolated from human scalp biopsy and then were characterized by Flow cytometry. SADSCS expressed CD90, CD44, and CD105 but did not express CD45 surface marker. Growth factors were used for chondrogenesis induction. Histology and immunohistology methods and gene expression by real-time PCR 14 days after induced cells have shown the feature of chondrocytes in their morphology and extracellular matrix in both inducing patterns of combination and cycling induction...
January 11, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29314704/use-of-a-novel-embolic-filter-in-carotid-artery-stenting-30-day-results-from-the-embolden-clinical-study
#19
William A Gray, Manish Mehta, Firas Alani, Karthikeshwar Kasirajan, Richard J Begg, J Michael Bacharach, Peter A Soukas
OBJECTIVES: The EMBOLDEN study was conducted to test the safety and efficacy of a novel emboli protection filter design for use in carotid artery stenting (CAS) in patients with severe carotid stenosis who were at high risk of operative complications from carotid endarterectomy (CEA). BACKGROUND: General considerations for filter design usually involve trade-offs between trackability/profile and wall apposition/capture efficiency. The GORE® Embolic Filter (GEF) is intended to address these design goals via a hybrid construction...
January 3, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29302039/targeting-the-corest-complex-with-dual-histone-deacetylase-and-demethylase-inhibitors
#20
Jay H Kalin, Muzhou Wu, Andrea V Gomez, Yun Song, Jayanta Das, Dawn Hayward, Nkosi Adejola, Mingxuan Wu, Izabela Panova, Hye Jin Chung, Edward Kim, Holly J Roberts, Justin M Roberts, Polina Prusevich, Jeliazko R Jeliazkov, Shourya S Roy Burman, Louise Fairall, Charles Milano, Abdulkerim Eroglu, Charlotte M Proby, Albena T Dinkova-Kostova, Wayne W Hancock, Jeffrey J Gray, James E Bradner, Sergio Valente, Antonello Mai, Nicole M Anders, Michelle A Rudek, Yong Hu, Byungwoo Ryu, John W R Schwabe, Andrea Mattevi, Rhoda M Alani, Philip A Cole
Here we report corin, a synthetic hybrid agent derived from the class I HDAC inhibitor (entinostat) and an LSD1 inhibitor (tranylcypromine analog). Enzymologic analysis reveals that corin potently targets the CoREST complex and shows more sustained inhibition of CoREST complex HDAC activity compared with entinostat. Cell-based experiments demonstrate that corin exhibits a superior anti-proliferative profile against several melanoma lines and cutaneous squamous cell carcinoma lines compared to its parent monofunctional inhibitors but is less toxic to melanocytes and keratinocytes...
January 4, 2018: Nature Communications
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