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Michelle S Cruz, Alani Diamond, Astrid Russell, Julie Marie Jameson
γδ T lymphocytes maintain skin homeostasis by balancing keratinocyte differentiation and proliferation with the destruction of infected or malignant cells. An imbalance in skin-resident T cell function can aggravate skin-related autoimmune diseases, impede tumor eradication, or disrupt proper wound healing. Much of the published work on human skin T cells attributes T cell function in the skin to αβ T cells, while γδ T cells are an often overlooked participant. This review details the roles played by both αβ and γδ T cells in healthy human skin and then focuses on their roles in skin diseases, such as psoriasis and alopecia areata...
2018: Frontiers in Immunology
Amber F MacDonald, Ahmed Bettaieb, Dallas R Donohoe, Dina S Alani, Anna Han, Yi Zhao, Jay Whelan
BACKGROUND: Zyflamend, a blend of herbal extracts, effectively inhibits tumor growth using preclinical models of castrate-resistant prostate cancer mediated in part by 5'-adenosine monophosphate-activated protein kinase (AMPK), a master energy sensor of the cell. Clinically, treatment with Zyflamend and/or metformin (activators of AMPK) had benefits in castrate-resistant prostate cancer patients who no longer responded to treatment. Two predominant upstream kinases are known to activate AMPK: liver kinase B1 (LKB1), a tumor suppressor, and calcium-calmodulin kinase kinase-2 (CaMKK2), a tumor promotor over-expressed in many cancers...
June 18, 2018: BMC Complementary and Alternative Medicine
Janett Riega-Torres, Guillermo Delgado-García, Julio César Salas-Alanís, Cassandra Skinner-Taylor, Lorena Pérez-Barbosa, Mario Garza-Elizondo, Celia Nohemí Sánchez-Domínguez, Luis Ángel Ceceñas-Falcón, Karim Mohamed-Noriega, Jesús Mohamed-Hamsho, David Vega-Morales
Objectives: This study aims to describe salivary beta-2 microglobulin (sB2M) levels in our setting and to assess the performance of sB2M for the diagnosis of Sjögren's syndrome (SS). Patients and methods: This cross-sectional, comparative study included 192 SS patients (2 males, 190 females; mean age 53.1 years; range 23 to 84 years) and 64 healthy controls (1 male, 63 females; mean age 46.9 years; range 21 to 82 years). Patients were divided into three groups as those with primary SS, secondary SS, and sicca non-Sjögren's syndrome (snSS)...
December 2017: Archives of Rheumatology
Olorunfemi Adebisi Onakoya, Chinonye Love Moses, Maxwell Ayodele Olokundun, Uchechukwu Emena Okorie, Fatai Alani Lawal
This study presents a data-set on the influence of managerial incentives on bank performance in selected Deposit Money Banks (DMB) in Nigeria. The use of managerial incentives to align interests of the principal and agent is advocated by agency theorists, but the peculiarity of the banking industry in terms of the role of regulation, capital structure, opacity and complexity of its transactions among others presents a different proposition in corporate governance research. The data collected over a longitudinal period between 2006 and 2016, provide information on specific managerial incentives and financial performance measures...
August 2018: Data in Brief
Muriel Sadlier, Angela Alani, Olu B Ipadeola, Kashif Ahmad
No abstract text is available yet for this article.
March 2018: JAAD Case Reports
Kamel Laribi, Delphine Bolle, Mustapha Alani, Habib Ghnaya, Saga Le Bourdelles, Anne Besançon, Jonathan Farhi, Nathalie Denizon, Alix Baugier de Materre
Iron overload has been associated with poor overall survival in patients with higher-risk myelodysplastic syndromes after allogeneic hematopoietic stem cell-transplantation, but has not been investigated in higher-risk MDS patients treated with hypomethylating agents. We evaluated the prognostic value of serum ferritin (SF) levels at diagnosis in a retrospective analysis of 48 patients with an intermediate 2 or high risk-international prognostic score treated with azacytidine (AZA). Overall survival probability at one and two years was 58% and 42% respectively...
June 5, 2018: Experimental Hematology
Titilope A Adeyemo, Oyesola O Ojewunmi, Idat A Oyetunji, Helen Rooks, David C Rees, Adebola O Akinsulie, Alani S Akanmu, Swee Lay Thein, Stephan Menzel
Genetic variants at three quantitative trait loci (QTL) for fetal haemoglobin (HbF), BCL11A, HBS1L-MYB and the β-globin gene cluster, have attracted interest as potential targets of therapeutic strategies for HbF reactivation in sickle cell anaemia (SCA). We carried out the first systematic evaluation of critical single nucleotide polymorphisms at these disease modifier loci in Nigerian patients with SCA. Common variants for BCL11A and HBS1L-MYB were strongly associated with HbF levels. At both loci, secondary association signals were detected, illustrating the mapping resolution attainable in this population...
2018: PloS One
Anne Kelly de Oliveira Nicolau Mantovani, Ivete Aparecida de Mattias Sartori, Luciana Reis Azevedo-Alanis, Rodrigo Tiossi, Flávia Noemy Gasparini Kiatake Fontão
PURPOSE: This retrospective chart review study assessed patient records to determine implant insertion torque (IT) and implant stability quotient (ISQ) values during implant placement to evaluate the correlation with cortical bone anchorage (mono- or bicortical). METHODS: Primary stability data (IT during implant placement surgery and ISQ values immediately after implant placement) and cone beam computed tomography of 33 patients (165 implants) were assessed. Patients were divided into the following groups: G1, implants with apical cortical bone contact; G2, implants with bicortical bone contact (apical and cervical regions); and G3, implants with cervical cortical bone contact...
June 6, 2018: Oral and Maxillofacial Surgery
Mariana Rinaldi, Aline C B R Johann, Patrícia Vida Cassi Bettega, Fabio Rocha, Sergio Aparecido Ignacio, Edvaldo Antonio Ribeiro Rosa, Luciana Reis Azevedo Alanis, Yusuf Althobaiti, Silvana da Silva Sapelli, Ana Maria Trindade Grégio Hardy
To evaluated the apoptosis in parotid glands of rats treated with Midazolam associated or not with Pilocarpine, Sixty Wistar rats were assigned to 6 groups: control group received saline solution for 30 days (S30) and 60 days (S60) and the other groups received Pilocarpine for 60 days (P60); Midazolam for 30 days (M30); Midazolam for 30 days and 30 days of saline (M30 + S30) and finally Midazolam for 30 days and 30 days of Midazolam and Pilocarpine (M30 + MP30). Histological sections were subjected to the TdT-mediated dUTP-biotin nick and labeling (TUNEL) technique...
May 30, 2018: Canadian Journal of Physiology and Pharmacology
Raina Croff, Kim Hoffman, Kelly Alanis-Hirsch, Jay Ford, Dennis McCarty, Laura Schmidt
Pharmacotherapy includes a growing number of clinically effective medications for substance use disorder, yet there are significant barriers to its adoption and implementation in routine clinical practice. The Medication Research Partnership (MRP) was a successful effort to promote adoption of pharmacotherapy for opioid and alcohol use disorders in nine substance abuse treatment centers and a commercial health plan. This qualitative analysis of interviews (n = 39) conducted with change leaders at baseline and at the end/beginning of 6-month change cycles explains how treatment centers overcame obstacles to the adoption, implementation, and sustainability of pharmacotherapy...
May 29, 2018: Journal of Behavioral Health Services & Research
Rine Nakanishi, Anas Alani, Suguru Matsumoto, Dong Li, Michael Fahmy, Jeby Abraham, Christopher Dailing, Alexander Broersen, Pieter H Kitslaar, Khurram Nasir, James K Min, Matthew J Budoff
Serial measurements of coronary plaque volume have been used to evaluate drug efficacy in atherosclerotic progression. However, the usefulness of computed tomography for this purpose is unknown. We investigated whether the change in total plaque volume on coronary computed tomographic angiography is associated with the change in segment plaque volume on intravascular ultrasound. We prospectively enrolled 11 consecutive patients (mean age, 56.3 ± 5 yr; 6 men) who were to undergo serial invasive coronary angiographic examinations with use of grayscale intravascular ultrasound and coronary computed tomography, performed <180 days apart at baseline and from 1 to 2 years later...
April 2018: Texas Heart Institute Journal
G Fernández Pérez, R Sánchez Escribano, A M García Vicente, A Luna Alcalá, J Ceballos Viro, R C Delgado Bolton, J C Vilanova Busquets, P Sánchez Rovira, M P Fierro Alanis, R García Figueiras, J E Alés Martínez
Imaging in oncology is an essential tool for patient management but its potential is being profoundly underutilized. Each of the techniques used in the diagnostic process also conveys functional information that can be relevant in treatment decision making. New imaging algorithms and techniques enhance our knowledge about the phenotype of the tumor and its potential response to different therapies. Functional imaging can be defined as the one that provides information beyond the purely morphological data, and include all the techniques that make it possible to measure specific physiological functions of the tumor, whereas molecular imaging would include techniques that allow us to measure metabolic changes...
May 25, 2018: Radiología
Adriana Pérez-Fortis, Joke Fleer, Maya J Schroevers, Patricia Alanís López, Juan José Sánchez Sosa, Christine Eulenburg, Adelita V Ranchor
OBJECTIVE: This study examined the course and predictors of supportive care needs among Mexican breast cancer patients for different cancer treatment trajectories. METHODS: Data from 172 (66.4% response rate) patients were considered in this observational longitudinal study. Participants were measured after diagnosis, neoadjuvant treatment, surgery, adjuvant treatment and the first post-treatment follow-up visit. Psychological, Health System and Information, Physical and Daily Living, Patient Care and Support, Sexual, and Additional care needs were measured with the Supportive Care Needs Survey (SCNS-SF34)...
May 26, 2018: Psycho-oncology
Bobby Brooke Herrera, Donald J Hamel, Philip Oshun, Rolake Akinsola, Alani S Akanmu, Charlotte A Chang, Philomena Eromon, Onikepe Folarin, Kayode T Adeyemi, Christian T Happi, Yichen Lu, Folasade Ogunsola, Phyllis J Kanki
BACKGROUND: Ebola virus (EBOV) caused more than 11,000 deaths during the 2013-2016 epidemic in West Africa without approved vaccines or immunotherapeutics. Despite its high lethality in some individuals, EBOV infection can produce little to no symptoms in others. A better understanding of the immune responses in individuals who experienced minimally symptomatic and asymptomatic infection could aid the development of more effective vaccines and antivirals against EBOV and related filoviruses...
May 24, 2018: PLoS Neglected Tropical Diseases
Kamel Laribi, Mustapha Alani, Catherine Truong, Alix Baugier de Materre
OBJECTIVE: Mature T-cell lymphomas are a heterogeneous group of T-cell malignancies with a poor outcome. The discovery of new molecular biomarkers has led to the emergence of new drugs in recent years that target various signaling pathways. METHOD: We examined all pertinent published patents through 2015 that analyzed novel methods for the diagnosis and treatment of T cell lymphoma, as well as related published and unpublished studies. Selection criteria were established before data collection...
May 16, 2018: Recent Patents on Anti-cancer Drug Discovery
Dolores Gutiérrez-Alanís, Jonathan Odilón Ojeda-Rivera, Lenin Yong-Villalobos, Luis Cárdenas-Torres, Luis Herrera-Estrella
Phosphorus (P) availability is a limiting factor for plant growth and development. Root tip contact with low Pi media triggers diverse changes in the root architecture of Arabidopsis thaliana. The most conspicuous among these modifications is the inhibition of root growth, which is triggered by a shift from an indeterminate to a determinate root growth program. This phenomenon takes place in the root tip and involves a reduction in cell elongation, a decrease in cell proliferation, and the induction of premature cell differentiation, resulting in meristem exhaustion...
May 12, 2018: Trends in Plant Science
Angela McHugh, Kenneth Fernandes, Andrew P South, Jemima E Mellerio, Julio C Salas-Alanís, Charlotte M Proby, Irene M Leigh, Mark K Saville
Proteasome inhibitors have distinct properties and the biochemical consequences of suppressing ubiquitin E1 enzymes and the proteasome differ. We compared the effects of the proteasome inhibitors bortezomib, ixazomib and carfilzomib and the ubiquitin E1 enzyme inhibitor MLN7243/TAK-243 on cell viability and cell death in normal keratinocytes and cutaneous squamous cell carcinoma (cSCC) cell lines. The effects of both a pulse of treatment and more extended incubation were investigated. This is relevant to directly-delivered therapy (topical treatment/intratumoral injection) where the time of exposure can be controlled and a short exposure may better reflect systemically-delivered inhibitor pharmacokinetics...
April 17, 2018: Oncotarget
Colin P Churchward, Raid G Alany, Lori A S Snyder
With the rising antibiotic resistance of many bacterial species, alternative treatments are necessary to combat infectious diseases. The World Health Organization and the US Centres for Disease Control and Prevention have warned that some infections, such as those from Neisseria gonorrhoeae, may be untreatable within a few years. One avenue of exploration is the use of antimicrobial fatty acids and their derivatives for therapeutic prevention or treatment of bacterial infections. Several studies have explored the activity of fatty acids and their derivatives, including monoglycerides against a variety of bacterial species...
May 7, 2018: Critical Reviews in Microbiology
A Zamilpa, C García-Alanís, M E López-Arellano, V M Hernández-Velázquez, M G Valladares-Cisneros, D O Salinas-Sánchez, P Mendoza-de Gives
The in vitro nematicidal effect of Chenopodium ambrosioides and Castela tortuosa n-hexane extracts (E-Cham and E-Cato, respectively) on Haemonchus contortus infective larvae (L3) and the anthelmintic effect of these extracts against the pre-adult stage of the parasite in gerbils were evaluated using both individual and combined extracts. The in vitro confrontation between larvae and extracts was performed in 24-well micro-titration plates. The results were considered 24 and 72 h post confrontation. The in vivo nematicidal effect was examined using gerbils as a study model...
May 6, 2018: Journal of Helminthology
Kamel Laribi, Mustapha Alani, Catherine Truong, Alix Baugier de Materre
Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of clinically aggressive diseases associated with poor outcome. Despite progress in the last several years, resulting in a deeper understanding of the natural history and biology of PTCL based on molecular profiling and next-generation sequencing, there is a need for improvement in efficacy of chemotherapeutic regimens for newly diagnosed patients. Treatment in the front-line setting is most often cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) or CHOP-like regimens, which are associated with a high failure rate and frequent relapses...
April 19, 2018: Oncologist
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