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https://www.readbyqxmd.com/read/28302582/characterization-of-pegylated-and-non-pegylated-liposomal-formulation-for-the-delivery-of-hypoxia-activated-vinblastine-n-oxide-for-the-treatment-of-solid-tumors
#1
Vidhi M Shah, Duc X Nguyen, Adel Alfatease, Shay Bracha, Adam Wg Alani
Solid tumors often contain hypoxic regions which are resistant to standard chemotherapy and radiotherapy. We have developed a liposomal delivery system for a prodrug of vinblastine (CPD100) which converts to the parent compound only in the presence of lower oxygen levels. As a part of this work we have developed and optimized two formulations of CPD100: one composed of sphingomyelin/cholesterol (55/45; mol/mol) (CPD100Li) and the other composed of sphingomyelin/cholesterol/PEG (55/40/5; mol/mol) (CPD100 PEGLi)...
March 14, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28298674/using-high-hydrostatic-pressures-to-retain-the-antioxidant-compounds-and-to-reduce-the-enzymatic-activity-of-a-pitaya-pineapple-stenocereus-sp-fragaria-ananassa-beverage
#2
Luisaldo Sandate-Flores, Magdalena de J Rostro-Alanis, Elena Ivonne Mancera-Andrade, Diego A Esquivel-Hernandez, Carlos Brambila-Paz, Roberto Parra-Saldívar, Jorge Welti-Chanes, Zamantha Escobedo-Avellaneda, José Rodríguez-Rodríguez
Pitaya (Stenocereus sp.) is a fruit native to arid and semiarid areas of Mexico. It has high antioxidant activity mainly due to its contents of betalains and phenolics, but its consumption is limited due to very short shelf-life and not very recognized flavor. A beverage of pitaya and pineapple was formulated to improve sensory properties. A high hydrostatic pressure (HHP) study at 400-600 MPa and 25 °C for 2-10 min was applied in the beverage and the effect on the contents of vitamin C, total phenolics and betalains, and the pectin methylesterase (PME) activity of pitaya-pineapple beverages, was evaluated...
March 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28272814/the-relationship-between-cardio-ankle-vascular-index-and-subclinical-atherosclerosis-evaluated-by-cardiac-computed-tomographic-angiography
#3
Suguru Matsumoto, Rine Nakanishi, Yanting Luo, Michael Kim, Anas Alani, Negin Nezarat, Christopher Dailing, Matthew J Budoff
BACKGROUND: The cardio-ankle vascular index (CAVI) is a new noninvasive index to evaluate arterial stiffness. We investigated whether CAVI can predict severity, extent, and burden of coronary artery disease by comparing results with cardiac computed tomographic angiography (CCTA). HYPOTHESIS: CAVI may predict the presence of subclinical atherosclerosis. METHODS: We prospectively enrolled 95 patients (66% male; mean age, 50 ± 16 years) who underwent both CCTA and CAVI consecutively...
March 8, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28240142/lipid-and-surfactant-based-formulations-drug-delivery-systems-and-dosage-forms
#4
Raid Alany
No abstract text is available yet for this article.
May 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28193730/mismatch-repair-incompatibilities-in-diverse-yeast-populations
#5
Duyen T Bui, Anne Friedrich, Najla Al-Sweel, Gianni Liti, Joseph Schacherer, Charles F Aquadro, Eric Alani
An elevated mutation rate can provide cells with a source of mutations to adapt to changing environments. We identified a negative-epistatic interaction involving naturally occurring variants in the MLH1 and PMS1 mismatch repair (MMR) genes of Saccharomyces cerevisiae We hypothesized that this MMR incompatibility, created through mating between divergent S. cerevisiae, yields mutator progeny that can rapidly but transiently adapt to an environmental stress. Here we analyzed the MLH1 and PMS1 genes across 1,010 S...
February 13, 2017: Genetics
https://www.readbyqxmd.com/read/28184055/clinical-applications-of-polytetrafluoroethylene-ptfe-tape-in-restorative-dentistry
#6
M M Sattar, M Patel, A Alani
Restorative dental procedures are ever developing; one reason for this can be attributed to newer materials with better handling properties and our ability to manipulate them more effectively. As a result various techniques have been described to aid clinicians in obtaining predictable results in restorative dental procedures. This article aims to review the use of plumber's tape to assist in adhesive, endodontic and implant related dental procedures, when compared to other available materials.
February 10, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28178908/oral-dosage-forms-and-drug-delivery-systems-tablets-oral-films-liquid-dosage-forms-oral-bioavailability-enhancement
#7
EDITORIAL
Raid Alany
No abstract text is available yet for this article.
March 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28174366/radiofrequency-glow-discharge-as-a-mode-of-disinfection-for-elastomeric-impression-materials
#8
Susan Mathew, Mathew M Alani, K N Velayudhan Nair, Sayij Haridas, P B Reba, Sherin A Thomas
INTRODUCTION: Prosthodontic practice involves procedures in which impressions of the maxillary and mandibular arches are mandatory. Cross infection is one of the major problems that can occur in regular dental practice. Every dentist should take utmost care to prevent cross infection as oral cavity is the source of variety of microorganisms which can often cause diseases that can be fatal. Although precautions, such as wearing of gloves and mask, sterilization of instruments are given importance, the need for disinfection of impressions is often neglected...
February 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28167165/the-use-of-a-custom-made-mouthguard-stabilizes-the-electromyographic-activity-of-the-masticatory-muscles-among-karate-d%C3%A5-athletes
#9
Gilsane Raquel, Eli Luis Namba, Daniel Bonotto, Edvaldo Antônio Ribeiro Rosa, Paula Cristina Trevilatto, Maria Ângela Naval Machado, Michelle Santos Vianna-Lara, Luciana Reis Azevedo-Alanis
AIMS: To analyze and compare the electromyographic activity of the temporal (anterior portion) and masseter muscles among Karate-Dō athletes before and after training, with and without the use of a mouthguard. METHODS: Twenty athletes (14 males and 6 females) with a mean age of 23.7 ± 7.5 years participated. They had surface electromyography recordings taken of their bilateral temporal and masseter muscles before and after training under the following conditions: no mouthguard, with a ready-made mouthguard, and with a custom-made mouthguard...
January 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/28165469/notch3-signaling-mediated-melanoma-endothelial-crosstalk-regulates-melanoma-stem-like-cell-homeostasis-and-niche-morphogenesis
#10
Mei-Yu Hsu, Moon Hee Yang, Caroline I Schnegg, Soonyean Hwang, Byungwoo Ryu, Rhoda M Alani
Melanoma is among the most virulent cancers, owing to its propensity to metastasize and its resistance to current therapies. The treatment failure is largely attributed to tumor heterogeneity, particularly subpopulations possessing stem cell-like properties, ie, melanoma stem-like cells (MSLCs). Evidence indicates that the MSLC phenotype is malleable and may be acquired by non-MSLCs through phenotypic switching upon appropriate stimuli, the so-called 'dynamic stemness'. Since the phenotypic characteristics and functional integrity of MSLCs depend on their vascular niche, using a two-dimensional (2D) melanoma-endothelium co-culture model, where the MSLC niche is recapitulated in vitro, we identified Notch3 signaling pathway as a micro-environmental cue governing MSLC phenotypic plasticity via pathway-specific gene expression arrays...
February 6, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28126392/poloxamer-based-thermoresponsive-ketorolac-tromethamine-in-situ-gel-preparations-design-characterisation-toxicity-and-transcorneal-permeation-studies
#11
Zeinab M A Fathalla, Anil Vangala, Michael Longman, Khaled A Khaled, Amal K Hussein, Omar H El-Garhy, Raid G Alany
This study was aimed at preparing, characterising and evaluating in situ gel formulations based on a blend of two hydrophilic polymers i.e. poloxamer 407 (P407) and poloxamer 188 (P188) for a sustained ocular delivery of ketorolac tromethamine (KT). Drug-polymer interaction studies were performed using DSC and FT-IR. The gelation temperature (Tsol-gel), gelation time, rheological behaviour, mucoadhesive characteristics of these gels, transcorneal permeation and ocular irritation as well as toxicity was investigated...
January 23, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28117622/solid-state-characterization-solid-dispersions-solubility-enhancement-drug-dissolution-and-drug-release
#12
EDITORIAL
Raid Alany
No abstract text is available yet for this article.
February 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28117200/synthesis-antimycobacterial-and-cytotoxic-activity-of-%C3%AE-%C3%AE-unsaturated-amides-and-2-4-disubstituted-oxazoline-derivatives
#13
Francisco G Avalos-Alanís, Eugenio Hernández-Fernández, Pilar Carranza-Rosales, Susana López-Cortina, Jorge Hernández-Fernández, Mario Ordóñez, Nancy E Guzmán-Delgado, Alejandro Morales-Vargas, Víctor M Velázquez-Moreno, María G Santiago-Mauricio
The synthesis of six α,β,-unsaturated amides and six 2,4-disubstituted oxazolines derivatives and their evaluation against two Mycobacterium tuberculosis strains (sensitive H37Rv and a resistant clinical isolate) is reported. 2,4-Disubstituted oxazolines (S)-3b,d,e were the most active in the sensitive strain with a MIC of 14.2, 13.6 and 10.8μM, respectively, and the compounds (S)-3d,f were the most active against resistant strain with a MIC of 6.8 and 7.4μM. The ex-vivo evaluation of hepatotoxicity on precision-cut rat liver slices was also tested for the α,β-unsaturated amides (S)-2b and (S)-2d,f and for the oxazolines (S)-3b and (S)-3d,f at different concentrations (5, 15 and 30μg/mL)...
January 10, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28097686/context-characterization-of-amino-acid-homorepeats-using-evolution-position-and-order
#14
Pablo Mier, Gregorio Alanis-Lobato, Miguel A Andrade-Navarro
Amino acid repeats, or homorepeats, are low complexity protein motifs consisting of tandem repetitions of a single amino acid. Their presence and relative number vary in different proteomes, and some studies have tried to address this variation, proteome by proteome. In this work, we present a full characterization of amino acid homorepeats across evolution. We studied the presence and differential usage of each possible homorepeat in proteomes from various taxonomic groups, using clusters of very similar proteins to eliminate redundancy...
January 18, 2017: Proteins
https://www.readbyqxmd.com/read/28050809/the-treatment-of-olecranon-fractures-in-adults
#15
REVIEW
A J Powell, O M Farhan-Alanie, J K Bryceland, T Nunn
Olecranon fractures are common. They are usually managed surgically with open reduction and either tension band wiring or plate fixation. Currently, there are few studies comparing fracture treatments. We aim to review the available literature to guide the orthopaedic surgeon on the management of these fractures. A literature review of peer-reviewed publications in international orthopaedic journals detailing olecranon fracture treatment was conducted. An additional focus was placed on the evidence base for and surgical outcomes of tension band wiring for common two-part fractures...
January 3, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/28048875/su-f-j-185-detection-of-low-contrast-objects-optimization-of-ct-simulation-reconstruction-protocol-parameters
#16
S Alani, A Schlocker, N Honig, B Corn
PURPOSE: CT simulation has become an integral component of modern RT planning and therefore must be continually optimized. We evaluated the detection of small and low-contrast regions in images obtained during CT simulation. METHODS: A CT phantom containing a contrast detail modulus for detection of low-contrast structures was used to optimize the CT reconstruction protocol for abdomen. The parameters (A) Pitch, (B) Reconstruction Filter, and (C) Rotation Time type were varied for assessment of image quality...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048850/su-g-brc-14-multi-lesion-multi-rx-brain-radiosurgery-with-novel-single-isocenter-technique
#17
N Honig, S Alani, A Schlocker, N Shtraus, A Kanner
PURPOSE: There is a strong trend to treat multiple brain metastases with radiosurgery rather than whole brain irradiation. This feasibility study investigates a novel planning technique for radio-surgical treatment of multiple brain lesions with differing dose prescriptions, a single isocenter, and dynamic conformal arcs. The novel technique will be compared to the well-established single-isocenter volumetric modulated arc therapy (VMAT) technique commonly used for treating brain lesions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048021/mo-fg-campus-tep2-03-multi-criteria-optimization-using-taguchi-method-for-srs-of-multiple-lesions-by-single-isocenter
#18
S Alani, N Honig, A Schlocker, B Corn
PURPOSE: This study utilizes the Taguchi Method to evaluate the VMAT planning parameters of single isocenter treatment plans for multiple brain metastases. An optimization model based on Taguchi and utility concept is employed to optimize the planning parameters including: arc arrangement, calculation grid size, calculation model, and beam energy on multiple performance characteristics namely conformity index and dose to normal brain. METHODS: Treatment plans, each with 4 metastatic brain lesions were planned using single isocenter technique...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28029433/mmp-1-and-mmp-8-expression-in-giant-cell-fibroma-and-inflammatory-fibrous-hyperplasia
#19
Henrique Climeck de Oliveira, André Tschoeke, Gabriele Claudino da Cruz, Lúcia Noronha, Rafaela Scariot de Moraes, Ricardo Alves Mesquita, Maria Cássia Ferreira de Aguiar, Patrícia Carlos Caldeira, Marina de Oliveira Ribas, Ana Maria Trindade Grégio, Luciana Reis Azevedo Alanis, Sérgio Aparecido Ignácio, Jean Nunes Dos Santos, Antonio Adilson Soares de Lima, Aline Cristina Batista Rodrigues Johann
The aim of this study is to compare the immunoexpression of metalloproteinases 1 and 8 in giant-cell fibroma, inflammatory fibrous hyperplasia and normal mucosa. Twenty-two cases of giant-cell fibroma, inflammatory fibrous hyperplasia and oral mucosa (control) each were subjected to immunohistochemistry using anti-metalloproteinase-1 and anti-metalloproteinase-8 antibodies. Eight images of each case were captured and analysed through the a) application of a count grid to count the number of positive neutrophils, macrophages, lymphocytes, plasma cells, fibroblasts and blood vessels to obtain the percentage of staining and b) semi-automated segmentation quantifying the stained area in square micrometres...
October 15, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28011289/immobilization-of-laccase-of-pycnoporus-sanguineus-cs43
#20
Luis A Gonzalez-Coronel, Marta Cobas, Magdalena de J Rostro-Alanis, Roberto Parra-Saldívar, Carlos Hernandez-Luna, Marta Pazos, M Ángeles Sanromán
Laccase from Pycnoporus sanguineus CS43 was successfully immobilized onto Immobead-150 and Eupergit-C by covalent binding and by entrapment in LentiKats. The highest immobilization was onto Immobead-150 (97.1±1.2%) compared to the other supports, LentiKats (89±1.1%) and Eupergit-C (83.2±1.4%). All three immobilized enzyme systems showed increased thermostability and better mechanical properties than free laccase. Moreover, after 5 cycles of reuse of these systems, 90% of initial laccase activity was retained...
December 21, 2016: New Biotechnology
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