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https://www.readbyqxmd.com/read/28097686/context-characterization-of-amino-acid-homorepeats-using-evolution-position-and-order
#1
Pablo Mier, Gregorio Alanis-Lobato, Miguel A Andrade-Navarro
Amino acid repeats, or homorepeats, are low complexity protein motifs consisting of tandem repetitions of a single amino acid. Their presence and relative number vary in different proteomes, and some studies have tried to address this variation, proteome by proteome. In this work, we present a full characterization of amino acid homorepeats across evolution. We studied the presence and differential usage of each possible homorepeat in proteomes from various taxonomic groups, using clusters of very similar proteins to eliminate redundancy...
January 18, 2017: Proteins
https://www.readbyqxmd.com/read/28050809/the-treatment-of-olecranon-fractures-in-adults
#2
REVIEW
A J Powell, O M Farhan-Alanie, J K Bryceland, T Nunn
Olecranon fractures are common. They are usually managed surgically with open reduction and either tension band wiring or plate fixation. Currently, there are few studies comparing fracture treatments. We aim to review the available literature to guide the orthopaedic surgeon on the management of these fractures. A literature review of peer-reviewed publications in international orthopaedic journals detailing olecranon fracture treatment was conducted. An additional focus was placed on the evidence base for and surgical outcomes of tension band wiring for common two-part fractures...
January 3, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/28048875/su-f-j-185-detection-of-low-contrast-objects-optimization-of-ct-simulation-reconstruction-protocol-parameters
#3
S Alani, A Schlocker, N Honig, B Corn
PURPOSE: CT simulation has become an integral component of modern RT planning and therefore must be continually optimized. We evaluated the detection of small and low-contrast regions in images obtained during CT simulation. METHODS: A CT phantom containing a contrast detail modulus for detection of low-contrast structures was used to optimize the CT reconstruction protocol for abdomen. The parameters (A) Pitch, (B) Reconstruction Filter, and (C) Rotation Time type were varied for assessment of image quality...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048850/su-g-brc-14-multi-lesion-multi-rx-brain-radiosurgery-with-novel-single-isocenter-technique
#4
N Honig, S Alani, A Schlocker, N Shtraus, A Kanner
PURPOSE: There is a strong trend to treat multiple brain metastases with radiosurgery rather than whole brain irradiation. This feasibility study investigates a novel planning technique for radio-surgical treatment of multiple brain lesions with differing dose prescriptions, a single isocenter, and dynamic conformal arcs. The novel technique will be compared to the well-established single-isocenter volumetric modulated arc therapy (VMAT) technique commonly used for treating brain lesions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048021/mo-fg-campus-tep2-03-multi-criteria-optimization-using-taguchi-method-for-srs-of-multiple-lesions-by-single-isocenter
#5
S Alani, N Honig, A Schlocker, B Corn
PURPOSE: This study utilizes the Taguchi Method to evaluate the VMAT planning parameters of single isocenter treatment plans for multiple brain metastases. An optimization model based on Taguchi and utility concept is employed to optimize the planning parameters including: arc arrangement, calculation grid size, calculation model, and beam energy on multiple performance characteristics namely conformity index and dose to normal brain. METHODS: Treatment plans, each with 4 metastatic brain lesions were planned using single isocenter technique...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28029433/mmp-1-and-mmp-8-expression-in-giant-cell-fibroma-and-inflammatory-fibrous-hyperplasia
#6
Henrique Climeck de Oliveira, André Tschoeke, Gabriele Claudino da Cruz, Lúcia Noronha, Rafaela Scariot de Moraes, Ricardo Alves Mesquita, Maria Cássia Ferreira de Aguiar, Patrícia Carlos Caldeira, Marina de Oliveira Ribas, Ana Maria Trindade Grégio, Luciana Reis Azevedo Alanis, Sérgio Aparecido Ignácio, Jean Nunes Dos Santos, Antonio Adilson Soares de Lima, Aline Cristina Batista Rodrigues Johann
The aim of this study is to compare the immunoexpression of metalloproteinases 1 and 8 in giant-cell fibroma, inflammatory fibrous hyperplasia and normal mucosa. Twenty-two cases of giant-cell fibroma, inflammatory fibrous hyperplasia and oral mucosa (control) each were subjected to immunohistochemistry using anti-metalloproteinase-1 and anti-metalloproteinase-8 antibodies. Eight images of each case were captured and analysed through the a) application of a count grid to count the number of positive neutrophils, macrophages, lymphocytes, plasma cells, fibroblasts and blood vessels to obtain the percentage of staining and b) semi-automated segmentation quantifying the stained area in square micrometres...
October 15, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28011289/immobilization-of-laccase-of-pycnoporus-sanguineus-cs43
#7
Luis A Gonzalez-Coronel, Marta Cobas, Magdalena de J Rostro-Alanis, Roberto Parra-Saldívar, Carlos Hernandez-Luna, Marta Pazos, M Ángeles Sanromán
Laccase from Pycnoporus sanguineus CS43 was successfully immobilized onto Immobead-150 and Eupergit-C by covalent binding and by entrapment in LentiKats. The highest immobilization was onto Immobead-150 (97.1±1.2%) compared to the other supports, LentiKats (89±1.1%) and Eupergit-C (83.2±1.4%). All three immobilized enzyme systems showed increased thermostability and better mechanical properties than free laccase. Moreover, after 5 cycles of reuse of these systems, 90% of initial laccase activity was retained...
December 21, 2016: New Biotechnology
https://www.readbyqxmd.com/read/27927239/the-relationship-between-blood-lead-levels-and-occupational-exposure-in-a-pregnant-population
#8
Osmel La-Llave-León, José Manuel Salas Pacheco, Sergio Estrada Martínez, Eloísa Esquivel Rodríguez, Francisco X Castellanos Juárez, Ada Sandoval Carrillo, Angélica María Lechuga Quiñones, Fernando Vázquez Alanís, Gonzalo García Vargas, Edna Madai Méndez Hernández, Jaime Duarte Sustaita
BACKGROUND: Pregnant women exposed to lead are at risk of suffering reproductive damages, such as miscarriage, preeclampsia, premature delivery and low birth weight. Despite that the workplace offers the greatest potential for lead exposure, there is relatively little information about occupational exposure to lead during pregnancy. This study aims to assess the association between blood lead levels and occupational exposure in pregnant women from Durango, Mexico. METHODS: A cross-sectional study was carried out in a population of 299 pregnant women...
December 7, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27924865/quantum-error-correction-protects-quantum-search-algorithms-against-decoherence
#9
Panagiotis Botsinis, Zunaira Babar, Dimitrios Alanis, Daryus Chandra, Hung Nguyen, Soon Xin Ng, Lajos Hanzo
When quantum computing becomes a wide-spread commercial reality, Quantum Search Algorithms (QSA) and especially Grover's QSA will inevitably be one of their main applications, constituting their cornerstone. Most of the literature assumes that the quantum circuits are free from decoherence. Practically, decoherence will remain unavoidable as is the Gaussian noise of classic circuits imposed by the Brownian motion of electrons, hence it may have to be mitigated. In this contribution, we investigate the effect of quantum noise on the performance of QSAs, in terms of their success probability as a function of the database size to be searched, when decoherence is modelled by depolarizing channels' deleterious effects imposed on the quantum gates...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27916273/identification-of-agnors-and-cytopathological-changes-in-oral-lichen-planus-lesions
#10
Stefânia Jeronimo Ferreira, Maria Ângela Naval Machado, Antônio Adilson Soares de Lima, Aline Cristina Batista Rodrigues Johann, Ana Maria Trindade Grégio, Luciana Reis Azevedo-Alanis
OBJECTIVE: To evaluate cytopathological changes in epithelial cells of the oral mucosa of patients with oral lichen planus (OLP) compared with patients without OLP. SUBJECTS AND METHODS: Swabs were collected from the oral mucosa of 20 patients with OLP (case group) and 20 patients without OLP (control group) using liquid-based cytology. After Papanicolaou staining, the smears were characterized based on Papanicolaou classification and degree of maturation. Nuclear area (NA) measurements, cytoplasmic area (CA) measurements, and the NA/CA ratio were determined from 50 epithelial cells per slide...
January 2017: Acta Histochemica
https://www.readbyqxmd.com/read/27904757/brain-hemorrhage-after-electrical-burn-injury-case-report-and-probable-mechanism
#11
Gutierrez Aceves Guillermo Axayacalt, Ceja Espinosa Alejandro, Rios Alanis Marcos, Ruiz Flores Milton Inocencio, Herrera Gonzalez Jose Alfredo
BACKGROUND: High-voltage electric injury may induce lesion in different organs. In addition to the local tissue damage, electrical injuries may lead to neurological deficits, musculoskeletal damage, and cardiovascular injury. Severe vascular damage may occur making the blood vessels involved prone to thrombosis and spontaneous rupture. CASE DESCRIPTION: Here, we present the case of a 39-year-old male who suffered an electrical burn with high tension wire causing intracranial bleeding...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27864334/deubiquitinase-otud6b-isoforms-are-important-regulators-of-growth-and-proliferation
#12
Anna Sobol, Caroline Askonas, Sara Alani, Megan J Weber, Vijayalakshmi Ananthanarayanan, Clodia Osipo, Maurizio Bocchetta
: Deubiquitinases (DUBs) are increasingly linked to the regulation of fundamental processes in normal and cancer cells, including DNA replication and repair, programmed cell death, and oncogenes and tumor suppressors signaling. Here evidence is presented that the deubiquitinase OTUD6B regulates protein synthesis in non-small cell lung cancer (NSCLC) cells, operating downstream from mTORC1. OTUD6B associates with the protein synthesis initiation complex and modifies components of the 48S preinitiation complex...
November 18, 2016: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/27845883/salivary-flow-rate-buffer-capacity-and-urea-concentration-in-adolescents-with-type-1-diabetes-mellitus
#13
Ivana Maria Saes Busato, Carlos Cesar De Antoni, Thiago Calcagnotto, Sérgio Aparecido Ignácio, Luciana Reis Azevedo-Alanis
BACKGROUND: The objective of the study was to analyze salivary flow rate, urea concentration, and buffer capacity in adolescents with type 1 diabetes mellitus (type 1 DM) in two different stages. METHODS: This study was performed on adolescents (14-19 years), allocated between two groups: type 1 DM group comprised 32 adolescents with type 1 DM, and non-type 1 DM group comprised 32 nondiabetics. The adolescents in type 1 DM group were evaluated at a baseline (T0) and after 15 months (T1), and those in non-type 1 DM group were only evaluated at T0...
December 1, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/27843269/pediatric-adenotonsillectomy-in-a-low-resource-setting-lessons-and-implications
#14
Sanyaolu Alani Ameye, Afolabi Muyiwa Owojuyigbe, Adekunle Adeyemo, Anthony T Adenekan, Sylvia Ouche
OBJECTIVES: To examine the practices related paediatric adenotonsillectomy in our setting especially in relation to blood request and transfusion, routine investigations, post-operative analgesic practice and complications. METHODS: We reviewed the record of paediatric patients who had adenotonsillectomy in our facility over a 5-year period to obtain relevant information to our study. RESULTS: There were 33 males and 19 females with mean age of 3...
July 2016: Nigerian Journal of Surgery: Official Publication of the Nigerian Surgical Research Society
https://www.readbyqxmd.com/read/27836020/high-levels-of-pre-treatment-hiv-drug-resistance-and-treatment-failure-in-nigerian-children
#15
Ragna S Boerma, T Sonia Boender, Kim C E Sigaloff, Tobias F Rinke de Wit, Michael Boele van Hensbroek, Nicaise Ndembi, Titilope Adeyemo, Edamisan O Temiye, Akin Osibogun, Pascale Ondoa, Job C Calis, Alani Sulaimon Akanmu
INTRODUCTION: Pre-treatment HIV drug resistance (PDR) is an increasing problem in sub-Saharan Africa. Children are an especially vulnerable population to develop PDR given that paediatric second-line treatment options are limited. Although monitoring of PDR is important, data on the paediatric prevalence in sub-Saharan Africa and its consequences for treatment outcomes are scarce. We designed a prospective paediatric cohort study to document the prevalence of PDR and its effect on subsequent treatment failure in Nigeria, the country with the second highest number of HIV-infected children in the world...
2016: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/27832954/efficient-approach-to-enhance-drug-solubility-by-particle-engineering-of-bovine-serum-albumin
#16
Mouhamad Khoder, Hamdy Abdelkader, Amr ElShaer, Ayman Karam, Mohammad Najlah, Raid G Alany
The aim of this study was to investigate the use of bovine serum albumin (BSA) as a solubility enhancer for indometacin (IND) as a model drug. IND-BSA solid dispersions were prepared by both spray drying and freeze drying techniques using IND:BSA solution (20:1 Molar Ratio (MR)) and IND:BSA suspension (100:1 MR). The solid state of IND in solid dispersions was characterised by SEM, DSC and XRD. The aqueous solubility of IND in the presence of increased amounts of BSA was evaluated. Additionally, IND dissolution and release profiles were evaluated...
December 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27832945/protein-protein-interactions-can-be-predicted-using-coiled-coil-co-evolution-patterns
#17
Pablo Mier, Gregorio Alanis-Lobato, Miguel A Andrade-Navarro
Protein-protein interactions are sometimes mediated by coiled coil structures. The evolutionary conservation of interacting orthologs in different species, along with the presence or absence of coiled coils in them, may help in the prediction of interacting pairs. Here, we illustrate how the presence of coiled coils in a protein can be exploited as a potential indicator for its interaction with another protein with coiled coils. The prediction capability of our strategy improves when restricting our dataset to highly reliable, known protein-protein interactions...
January 7, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/27822337/on-the-anticataractogenic-effects-of-l-carnosine-is-it-best-described-as-an-antioxidant-metal-chelating-agent-or-glycation-inhibitor
#18
Hamdy Abdelkader, Michael Longman, Raid G Alany, Barbara Pierscionek
Purpose. L-Carnosine is a naturally occurring dipeptide which recently gained popularity as an anticataractogenic agent due to its purported antioxidant activities. There is a paucity of research and conclusive evidence to support such claims. This work offers compelling data that help clarify the mechanism(s) behind the anticataract properties of L-carnosine. Methods. Direct in vitro antioxidant free radical scavenging properties were assayed using three different antioxidant (TEAC, CUPRAC, and DPPH) assays...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27798628/mycobacterium-tuberculosis-lineage-4-comprises-globally-distributed-and-geographically-restricted-sublineages
#19
David Stucki, Daniela Brites, Leïla Jeljeli, Mireia Coscolla, Qingyun Liu, Andrej Trauner, Lukas Fenner, Liliana Rutaihwa, Sonia Borrell, Tao Luo, Qian Gao, Midori Kato-Maeda, Marie Ballif, Matthias Egger, Rita Macedo, Helmi Mardassi, Milagros Moreno, Griselda Tudo Vilanova, Janet Fyfe, Maria Globan, Jackson Thomas, Frances Jamieson, Jennifer L Guthrie, Adwoa Asante-Poku, Dorothy Yeboah-Manu, Eddie Wampande, Willy Ssengooba, Moses Joloba, W Henry Boom, Indira Basu, James Bower, Margarida Saraiva, Sidra E G Vasconcellos, Philip Suffys, Anastasia Koch, Robert Wilkinson, Linda Gail-Bekker, Bijaya Malla, Serej D Ley, Hans-Peter Beck, Bouke C de Jong, Kadri Toit, Elisabeth Sanchez-Padilla, Maryline Bonnet, Ana Gil-Brusola, Matthias Frank, Veronique N Penlap Beng, Kathleen Eisenach, Issam Alani, Perpetual Wangui Ndung'u, Gunturu Revathi, Florian Gehre, Suriya Akter, Francine Ntoumi, Lynsey Stewart-Isherwood, Nyanda E Ntinginya, Andrea Rachow, Michael Hoelscher, Daniela Maria Cirillo, Girts Skenders, Sven Hoffner, Daiva Bakonyte, Petras Stakenas, Roland Diel, Valeriu Crudu, Olga Moldovan, Sahal Al-Hajoj, Larissa Otero, Francesca Barletta, E Jane Carter, Lameck Diero, Philip Supply, Iñaki Comas, Stefan Niemann, Sebastien Gagneux
Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists...
December 2016: Nature Genetics
https://www.readbyqxmd.com/read/27794551/hippie-v2-0-enhancing-meaningfulness-and-reliability-of-protein-protein-interaction-networks
#20
Gregorio Alanis-Lobato, Miguel A Andrade-Navarro, Martin H Schaefer
The increasing number of experimentally detected interactions between proteins makes it difficult for researchers to extract the interactions relevant for specific biological processes or diseases. This makes it necessary to accompany the large-scale detection of protein-protein interactions (PPIs) with strategies and tools to generate meaningful PPI subnetworks. To this end, we generated the Human Integrated Protein-Protein Interaction rEference or HIPPIE (http://cbdm.uni-mainz.de/hippie/). HIPPIE is a one-stop resource for the generation and interpretation of PPI networks relevant to a specific research question...
January 4, 2017: Nucleic Acids Research
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