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https://www.readbyqxmd.com/read/29043702/n-acetylcysteine-compared-to-metformin-improves-the-expression-profile-of-growth-differentiation-factor-9-and-receptor-tyrosine-kinase-c-kit-in-the-oocytes-of-patients-with-polycystic-ovarian-syndrome
#1
Ebrahim Cheraghi, Malek Soleimani Mehranjani, Seyed Mohammad Ali Shariatzadeh, Mohammad Hossein Nasr Esfahani, Behrang Alani
Background: Paracrine disruption of growth factors in women with polycystic ovarian syndrome (PCOS) results in production of low quality oocyte, especially following ovulation induction. The aim of this study was to investigate the effects of metformin (MET), N-acetylcysteine (NAC) and their combination on the hormonal levels and expression profile of GDF-9, BMP-15 and c-kit, as hallmarks of oocyte quality, in PCOS patients. MATERIALS AND METHODS: This prospective randomized, double-blind, placebo controlled trial aims to study the effects of MET, NAC and their combination (MET+NAC) on expression of GDF-9, BMP-15 and c-kit mRNA in oocytes [10 at the germinal vesicle (GV) stage, 10 at the MI stage, and 10 at the MII stage from per group] derived following ovulation induction in PCOS...
January 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29038739/unusual-case-of-superior-vena-cava-syndrome-caused-by-intravascular-thyroid-metastasis
#2
Vanesa Varela Pose, María Patricia Fierro Alanis, Anaberta Bermudez Naveira, Oskarina Lourdes Silva Gonzalez, Jorge Fernandez Noya, Urbano Anido Herranz, Rafael Lopez Lopez
Superior cava venous obstruction use to show a typical clinical presentation and a CT scan or even an ultrasonography can be sufficient to achieve an accurate diagnosis, but in this case, to obtain the final diagnosis, a multimodal assessment is needed. This case report shows a multidisciplinary approach which helped diagnose a complicated case, where conventional diagnostic methods were not enough.
2017: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29033069/surgery-for-hepatic-hidatidosis-risk-factors-and-variables-associated-with-postoperative-morbidity-overview-of-the-existing-evidence
#3
Carlos Manterola, Tamara Otzen, Gloria Muñoz, Martín Alanis, Eileen Kruuse, Gustavo Figueroa
There are few publications related to postoperative morbidity in hepatic hydatidosis and these have mixed results. The aim of this study was to determine risk and protective factors of postoperative morbidity in patients operated on for hepatic hydatidosis. A comprehensive review was made of the evidence, based on systematic reviews, clinical analyses and observational studies, obtained from the Trip Database, BVS, SciELO, Cochrane Central Register of Controlled Trials, WoS, MEDLINE, EMBASE, SCOPUS, EBSCOhost, IBECS, ePORTUGUESe, LILACS and WHOLIS...
October 12, 2017: Cirugía Española
https://www.readbyqxmd.com/read/29032428/usability-operations-on-touch-mobile-devices-for-users-with-autism
#4
Angeles Quezada, Reyes Juárez-Ramírez, Samantha Jiménez, Alan Ramírez Noriega, Sergio Inzunza, Arnulfo Alanis Garza
The Autistic Spectrum Disorder is a cognitive disorder that affects the cognitive and motor skills; due that, users cannot perform digital and fine motor tasks. It is necessary to create software applications that adapt to the abilities of these users. In recent years has been an increase in the research of the use of technology to support autistic users to develop their communication skills and to improve learning. However, the applications' usability for disable users is not assessed objectively as the existing models do not consider interaction operators for disable users...
October 14, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/29031173/an-unusual-case-of-transpelvic-impalement-injury-a-case-report
#5
Mushrek Alani, Saeed Mahmood, Ayman El-Menyar, Sajid Atique, Hassan Al-Thani, Ruben Peralta
INTRODUCTION: Impalement injury is a rare type of mechanical injury following forceful insertion of projecting object into the body. Careful planning for removal of the impaling object is essential to decrease the blood loss and preserve the function of the injured organ. PRESENTATION OF CASE: A 27 year-old male fell from 4m height over a U shaped projecting up metallic bar. The bar penetrated the left side of the pelvis and traversed through the left iliac bone causing a comminuted fracture in the supra-acetabular region extending to the left psoas muscle, injuring the viscera and causing fracture of the right femur...
October 5, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28984636/coronary-artery-positive-remodeling-in-current-smokers
#6
Anas Alani, Yanting Luo, Rine Nakanishim, Suguru Matsumoto, Matthew J Budoff
BACKGROUND: This study aims to evaluate the association of the coronary artery-positive remodeling (CAPR) observed on cardiac computed tomography angiography (CCTA) with cigarette smoking. PATIENTS AND METHODS: This retrospective case-control study enrolled 178 consecutive patients with CAPR plaque (case group) and 180 consecutive patients with coronary artery plaque, but no positive remodeling (control group). CAPR was evaluated in CCTA images and defined as at least 10% larger vessel diameter at the plaque site compared with a normal reference segment...
October 3, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28958074/fistula-of-right-internal-thoracic-artery-as-a-rare-cause-of-chest-pain
#7
Amer Harky, Hewran A Mohammad, Megan Garner, Muhamed S Alani
Variation in the origin of the internal thoracic arteries has been previously described and reported in the literature; however, there has been no report of an anomalous termination of the right internal thoracic artery into the pulmonary vein persisting and presenting in adult life. We report the case of the right internal thoracic artery originating from the first part of subclavian artery but terminating into the right superior pulmonary vein that presented during the third decade of life.
September 11, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28954802/henry-ford-heart-score-randomized-trial-rapid-discharge-of-patients-evaluated-for-possible-myocardial-infarction
#8
Tiberio M Frisoli, Richard Nowak, Kaleigh L Evans, Michael Harrison, Maath Alani, Saira Varghese, Mehnaz Rahman, Samantha Noll, Katherine R Flannery, Alex Michaels, Mishel Tabaku, Gordon Jacobsen, James McCord
BACKGROUND: Hospital evaluation of patients with chest pain is common and costly. The HEART score risk stratification tool that merges troponin testing into a clinical risk model for evaluation emergency department patients with possible acute myocardial infarction (AMI) has been shown to effectively identify a substantial low-risk subset of patients possibly safe for early discharge without stress testing, a strategy that could have tremendous healthcare savings implications. METHOD AND RESULTS: A total of 105 patients evaluated for AMI in the emergency departments of 2 teaching hospitals in the Henry Ford Health System (Detroit and West Bloomfield, MI), between February 2014 and May 2015, with a modified HEART score ≤3 (which includes cardiac troponin I <0...
October 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28950123/a-novel-method-for-bioethanol-production-using-immobilized-yeast-cells-in-calcium-alginate-films-and-hybrid-composite-pervaporation-membrane
#9
Eduardo Leal Isla Santos, Magdalena Rostro-Alanís, Roberto Parra-Saldívar, Alejandro J Alvarez
Fermentation of sugar for production of ethanol was carried out using Saccharomyces cerevisiae cells immobilized in calcium alginate films. Thin films of calcium alginate casted on a microchannel surface were used instead of the typical spherical bead configuration. Yeast immobilized on alginate films produced a higher ethanol yield than free yeast cells under the same fermentation conditions. Also, a silicalite-1/poly dimethyl siloxane composite pervaporation membrane was synthesized for ethanol separation, and characterized with flux and separation factor...
September 18, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28945665/validation-of-the-omron-hem-7320-la-upper-arm-blood-pressure-monitor-with-intelli-wrap-technology-cuff-hem-fl1-for-self-measurement-and-clinic-use-according-to-the-european-society-of-hypertension-international-protocol-revision-2010-in-the-mexican-population
#10
Fernando Grover-Páez, Ernesto G Cardona-Muñoz, David Cardona-Müller, Víctor H Guzmán-Saldívar, Mariana Rodríguez-De la Cerda, Mayra B Jiménez-Cázarez, Sylvia E Totsuka-Sutto, Guillermo A Alanis-Sánchez, Carlos G Ramos-Becerra
The aim of this study was to determine the accuracy of the Omron HEM-7320-LA with Intelli Wrap technology cuff HEM-FL1 for self-measurement and clinic blood pressure (BP) measurement according to the European Society of Hypertension International Protocol revision 2010. The evaluation was performed in 39 individuals. The mean age of the participants was 47.9±14 years; systolic BP was 145.2±24.3 mmHg (range: 97-190), diastolic BP was 90.9±12.9 mmHg (range: 68-120), and arm circumference was 30.8±4 cm (range: 25-38...
September 22, 2017: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/28935327/anomalous-right-internal-thoracic-artery-terminating-in-the-right-superior-pulmonary-vein
#11
Amer Harky, Hewran A Mohammad, Megan Garner, Mubdir Ali, Muhamed S Alani
Variation in the origin of the internal thoracic arteries has been previously described and reported in the literature; however, there has been no report of an anomalous termination of the right internal thoracic artery (RITA) in the pulmonary vein persisting and presenting in adult life. We report the case of a right internal thoracic artery originating from the first part of the subclavian artery but terminating in the right superior pulmonary vein that presented during the third decade of life.
October 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28930061/promoting-adoption-of-medication-for-opioid-and-alcohol-use-disorders-through-system-change
#12
James H Ford, Amanda J Abraham, Nicoleta Lupulescu-Mann, Raina Croff, Kim A Hoffman, Kelly Alanis-Hirsch, Mady Chalk, Laura Schmidt, Dennis McCarty
OBJECTIVE: The Medication Research Partnership (MRP), a collaboration between a national commercial health plan and nine addiction treatment centers, implemented organizational and system changes to promote use of federally approved medications for treatment of alcohol and opioid use disorders. METHOD: A difference-in-differences analysis examined change over time in the percentage of patients receiving a prescription medication for alcohol or opioid use disorders treated in MRP (n = 9) and comparison (n = 15) sites...
September 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28927315/systematic-review-and-meta-analysis-of-the-epidemiology-of-polyautoimmunity-in-sj%C3%A3-gren-s-syndrome-secondary-sj%C3%A3-gren-s-syndrome-focusing-on-autoimmune-rheumatic-diseases
#13
H Alani, J R Henty, N L Thompson, E Jury, C Ciurtin
OBJECTIVE: The epidemiology of polyautoimmunity in Sjögren's syndrome (secondary Sjögren's syndrome - sSS) is not well defined and has not been investigated before using a systematic approach. We conducted a systematic review of the epidemiology of sSS associated with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), scleroderma, and myositis, assessing the prevalence rates (PRs) and clinical and serological features of sSS. METHOD: A systematic literature search of PubMed and Embase databases (updated to March 2016) was performed to identify all published data on PR, demographic profile, clinical manifestations, laboratory features, and causes of death associated with sSS...
September 20, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28917987/development-and-characterisation-of-electrospun-timolol-maleate-loaded-polymeric-contact-lens-coatings-containing-various-permeation-enhancers
#14
Prina Mehta, Ali A Al-Kinani, Muhammad Sohail Arshad, Ming-Wei Chang, Raid G Alany, Zeeshan Ahmad
Despite exponential growth in research relating to sustained and controlled ocular drug delivery, anatomical and chemical barriers of the eye still pose formulation challenges. Nanotechnology integration into the pharmaceutical industry has aided efforts in potential ocular drug device development. Here, the integration and in vitro effect of four different permeation enhancers (PEs) on the release of anti-glaucoma drug timolol maleate (TM) from polymeric nanofiber formulations is explored. Electrohydrodynamic (EHD) engineering, more specifically electrospinning, was used to engineer nanofibers (NFs) which coated the exterior of contact lenses...
September 14, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28915546/emergent-contaminants-endocrine-disruptors-and-their-laccase-assisted-degradation-a-review
#15
REVIEW
Carlos Barrios-Estrada, Magdalena de Jesús Rostro-Alanis, Blanca Delia Muñoz-Gutiérrez, Hafiz M N Iqbal, Soundarapandian Kannan, Roberto Parra-Saldívar
Herein, an effort has been made to highlight the trends of the state-of-the-art of laccase-assisted degradation of emerging contaminants at large and endocrine disruptors in particular. Since first described in the 19th century, laccase has received particular interest for inter- and multidisciplinary investigations due to its uniqueness and remarkable biotechnological applicability. There has always been a paramount concern over the widespread occurrences of various pollutant types, around the globe. Therefore, pollution free processes are gaining ground all over the world...
September 11, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28913409/nonepidemic-kaposi-sarcoma-a-recently-proposed-category
#16
Tiffany Hinojosa, Daniel J Lewis, Melinda Liu, Gustavo Garza, Ramya Vangipuram, Elmira Ramos, Julio César Salas-Alanis, Zeena Y Nawas, Stephen K Tyring
No abstract text is available yet for this article.
September 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28880908/prostacyclin-thromboxane-and-glomerular-filtration-rate-are-abnormal-in-sickle-cell-pregnancy
#17
Opeyemi Abayomi Obilade, Alani Suleimon Akanmu, Fiona Broughton Pipkin, Bosede Bukola Afolabi
BACKGROUND: Pregnancy increases the risk of morbidity and mortality in sickle cell disease. We previously showed pregnant women with sickle cell disease to have a relatively low plasma renin concentration in late pregnancy, associated with a lack of the expected plasma volume expansion. We hypothesized this to be due to increased systemic vascular resistance through an imbalance between the vasodilator prostacyclin and vasoconstrictor thromboxane, associated with decreased glomerular filtration rate (GFR)...
2017: PloS One
https://www.readbyqxmd.com/read/28868838/aluminium-induced-oxidative-stress-apoptosis-and-alterations-in-testicular-tissue-and-sperm-quality-in-wistar-rats-ameliorative-effects-of-curcumin
#18
Ebrahim Cheraghi, Alireza Golkar, Kambiz Roshanaei, Behrang Alani
Background: Reproductive toxicity is a major challenge associated with aluminum (Al) exposure. No studies have evaluated the possible effects of curcumin (CUR) on Al-induced reproductive dysfunction. Therefore, this study investigated the effects of CUR treatment on Al-induced reproductive damage. MATERIALS AND METHODS: In this experimental study, 40 male Wistar rats were allocated to the five groups (n=8) based on the treatment they received: no treatment (control), solvent [dimethyl sulfoxide (DMSO) or distilled water], CUR 10 mg/kg body weight (BW), Al chloride 10 mg/kg BW, and CUR+Al chloride (10 mg/kg BW/each alone)...
October 2017: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/28828097/radiologic-images-of-an-aggressive-implant-associated-fibromatosis-of-the-breast-and-chest-wall-case-report-and-review-of-the-literature
#19
Lourdes Alanis, Robyn Roth, Nati Lerman, Julieta E Barroeta, Pauline Germaine
Fibromatosis of the breast is a rare benign disease compromising <0.2% of all primary breast tumors. Although the chest wall is a common location, occurrences of implant-associated fibromatosis of the breast are extremely rare; only 33 cases have been reported. We present a case of a 42-year-old female who underwent breast augmentation with silicone breast implants, and 2 years later developed an aggressive implant-associated fibromatosis of the breast and chest wall. On imaging studies, the tumor mimicked breast carcinoma, and despite chemotherapy, the fibromatosis rapidly enlarged and was locally invasive requiring wide surgical excision...
September 2017: Radiology case reports
https://www.readbyqxmd.com/read/28827832/mlh3-mutations-in-baker-s-yeast-alter-meiotic-recombination-outcomes-by-increasing-noncrossover-events-genome-wide
#20
Najla Al-Sweel, Vandana Raghavan, Abhishek Dutta, V P Ajith, Luigi Di Vietro, Nabila Khondakar, Carol M Manhart, Jennifer A Surtees, K T Nishant, Eric Alani
Mlh1-Mlh3 is an endonuclease hypothesized to act in meiosis to resolve double Holliday junctions into crossovers. It also plays a minor role in eukaryotic DNA mismatch repair (MMR). To understand how Mlh1-Mlh3 functions in both meiosis and MMR, we analyzed in baker's yeast 60 new mlh3 alleles. Five alleles specifically disrupted MMR, whereas one (mlh3-32) specifically disrupted meiotic crossing over. Mlh1-mlh3 representatives for each class were purified and characterized. Both Mlh1-mlh3-32 (MMR+, crossover-) and Mlh1-mlh3-45 (MMR-, crossover+) displayed wild-type endonuclease activities in vitro...
August 2017: PLoS Genetics
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