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https://www.readbyqxmd.com/read/27834638/transformation-invariant-control-of-voxel-wise-false-discovery-rate
#1
Junning Li, Yonggang Shi, Arthur W Toga
Multiple testing for statistical maps remains a critical and challenging problem in brain mapping. Since the false discovery rate (FDR) criterion was introduced to the neuroimaging community a decade ago, many variations have been proposed, mainly to enhance detection power. However, a fundamental geometrical property known as transformation invariance has not been adequately addressed, especially for the voxel-wise FDR. Correction of multiple testing applied after spatial transformation is not necessarily equivalent to transformation applied after correction in the original space...
October 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/27812347/t2-imaging-changes-in-the-nigrosome-1-relate-to-clinical-measures-of-parkinson-s-disease
#2
Katherine A Fu, Romil Nathan, Ivo D Dinov, Junning Li, Arthur W Toga
BACKGROUND: The nigrosome-1 region of the substantia nigra (SN) undergoes the greatest and earliest dopaminergic neuron loss in Parkinson's disease (PD). As T2-weighted magnetic resonance imaging (MRI) scans are often collected with routine clinical MRI protocols, this investigation aims to determine whether T2-imaging changes in the nigrosome-1 are related to clinical measures of PD and to assess their potential as a more clinically accessible biomarker for PD. METHODS: Voxel intensity ratios were calculated for T2-weighted MRI scans from 47 subjects from the Parkinson's Progression Markers Initiative database...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27810160/immature-oocyte-retrieval-and-in%C3%A2-vitro-oocyte-maturation-at-different-phases-of-the-menstrual-cycle-in-women-with-cancer-who-require-urgent-gonadotoxic-treatment
#3
Helene Creux, Patricia Monnier, Weon-Young Son, Togas Tulandi, William Buckett
OBJECTIVE: To evaluate the feasibility and the efficacy of in vitro maturation (IVM) when immature oocyte collection was performed in the early follicular, late follicular, or luteal phases in women with cancer who require urgent chemotherapy. DESIGN: Retrospective cohort study. SETTING: University teaching hospital. PATIENT(S): One-hundred and sixty-four women with cancer undergoing IVM treatment for fertility preservation...
October 31, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27804979/laminin-guided-highly-efficient-endothelial-commitment-from-human-pluripotent-stem-cells
#4
Ryo Ohta, Akira Niwa, Yukimasa Taniguchi, Naoya M Suzuki, Junko Toga, Emiko Yagi, Norikazu Saiki, Yoko Nishinaka-Arai, Chihiro Okada, Akira Watanabe, Tatsutoshi Nakahata, Kiyotoshi Sekiguchi, Megumu K Saito
Obtaining highly purified differentiated cells via directed differentiation from human pluripotent stem cells (hPSCs) is an essential step for their clinical application. Among the various conditions that should be optimized, the precise role and contribution of the extracellular matrix (ECM) during differentiation are relatively unclear. Here, using a short fragment of laminin 411 (LM411-E8), an ECM predominantly expressed in the vascular endothelial basement membrane, we demonstrate that the directed switching of defined ECMs robustly yields highly-purified (>95%) endothelial progenitor cells (PSC-EPCs) without cell sorting from hPSCs in an integrin-laminin axis-dependent manner...
November 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27784320/sirt1-expression-is-associated-with-cd31-expression-in-blood-cells-from-patients-with-chronic-obstructive-pulmonary-disease
#5
Ryo Kato, Shiro Mizuno, Maiko Kadowaki, Kohei Shiozaki, Masaya Akai, Ken Nakagawa, Taku Oikawa, Masaharu Iguchi, Kazuhiro Osanai, Takeshi Ishizaki, Norbert F Voelkel, Hirohisa Toga
BACKGROUND: Cigarette smoke induced oxidative stress has been shown to reduce silent information regulator 1 (Sirt1) levels in lung tissue from smokers and patients with COPD patients. Sirt1 is known to inhibit endothelial senescence and may play a protective role in vascular cells. Endothelial progenitor cells (EPCs) are mobilized into circulation under various pathophysiological conditions, and are thought to play an important role in tissue repair in chronic obstructive lung disease (COPD)...
October 27, 2016: Respiratory Research
https://www.readbyqxmd.com/read/27755367/ultra-high-field-magnetic-resonance-imaging-of-the-human-inner-ear-at-11-7%C3%A2-tesla
#6
David S Thylur, Russell E Jacobs, John L Go, Arthur W Toga, John K Niparko
OBJECTIVE: To evaluate the ability of ultra-high-field magnetic resonance imaging (UHF-MRI) at 11.7 T to visualize membranous structures of the human inner ear. SPECIMENS: Three temporal bones were extracted from cadaveric human heads for use with small-bore UHF-MRI. INTERVENTION: Ex vivo cadaveric temporal bone specimens were imaged using an 11.7 T magnetic resonance imaging (MRI) scanner via T1- and T2-weighted-imaging with and without contrast...
October 12, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27694991/novel-genetic-loci-underlying-human-intracranial-volume-identified-through-genome-wide-association
#7
Hieab H H Adams, Derrek P Hibar, Vincent Chouraki, Jason L Stein, Paul A Nyquist, Miguel E Rentería, Stella Trompet, Alejandro Arias-Vasquez, Sudha Seshadri, Sylvane Desrivières, Ashley H Beecham, Neda Jahanshad, Katharina Wittfeld, Sven J Van der Lee, Lucija Abramovic, Saud Alhusaini, Najaf Amin, Micael Andersson, Konstantinos Arfanakis, Benjamin S Aribisala, Nicola J Armstrong, Lavinia Athanasiu, Tomas Axelsson, Alexa Beiser, Manon Bernard, Joshua C Bis, Laura M E Blanken, Susan H Blanton, Marc M Bohlken, Marco P Boks, Janita Bralten, Adam M Brickman, Owen Carmichael, M Mallar Chakravarty, Ganesh Chauhan, Qiang Chen, Christopher R K Ching, Gabriel Cuellar-Partida, Anouk Den Braber, Nhat Trung Doan, Stefan Ehrlich, Irina Filippi, Tian Ge, Sudheer Giddaluru, Aaron L Goldman, Rebecca F Gottesman, Corina U Greven, Oliver Grimm, Michael E Griswold, Tulio Guadalupe, Johanna Hass, Unn K Haukvik, Saima Hilal, Edith Hofer, David Hoehn, Avram J Holmes, Martine Hoogman, Deborah Janowitz, Tianye Jia, Dalia Kasperaviciute, Sungeun Kim, Marieke Klein, Bernd Kraemer, Phil H Lee, Jiemin Liao, David C M Liewald, Lorna M Lopez, Michelle Luciano, Christine Macare, Andre Marquand, Mar Matarin, Karen A Mather, Manuel Mattheisen, Bernard Mazoyer, David R McKay, Rebekah McWhirter, Yuri Milaneschi, Nazanin Mirza-Schreiber, Ryan L Muetzel, Susana Muñoz Maniega, Kwangsik Nho, Allison C Nugent, Loes M Olde Loohuis, Jaap Oosterlaan, Martina Papmeyer, Irene Pappa, Lukas Pirpamer, Sara Pudas, Benno Pütz, Kumar B Rajan, Adaikalavan Ramasamy, Jennifer S Richards, Shannon L Risacher, Roberto Roiz-Santiañez, Nanda Rommelse, Emma J Rose, Natalie A Royle, Tatjana Rundek, Philipp G Sämann, Claudia L Satizabal, Lianne Schmaal, Andrew J Schork, Li Shen, Jean Shin, Elena Shumskaya, Albert V Smith, Emma Sprooten, Lachlan T Strike, Alexander Teumer, Russell Thomson, Diana Tordesillas-Gutierrez, Roberto Toro, Daniah Trabzuni, Dhananjay Vaidya, Jeroen Van der Grond, Dennis Van der Meer, Marjolein M J Van Donkelaar, Kristel R Van Eijk, Theo G M Van Erp, Daan Van Rooij, Esther Walton, Lars T Westlye, Christopher D Whelan, Beverly G Windham, Anderson M Winkler, Girma Woldehawariat, Christiane Wolf, Thomas Wolfers, Bing Xu, Lisa R Yanek, Jingyun Yang, Alex Zijdenbos, Marcel P Zwiers, Ingrid Agartz, Neelum T Aggarwal, Laura Almasy, David Ames, Philippe Amouyel, Ole A Andreassen, Sampath Arepalli, Amelia A Assareh, Sandra Barral, Mark E Bastin, Diane M Becker, James T Becker, David A Bennett, John Blangero, Hans van Bokhoven, Dorret I Boomsma, Henry Brodaty, Rachel M Brouwer, Han G Brunner, Randy L Buckner, Jan K Buitelaar, Kazima B Bulayeva, Wiepke Cahn, Vince D Calhoun, Dara M Cannon, Gianpiero L Cavalleri, Christopher Chen, Ching-Yu Cheng, Sven Cichon, Mark R Cookson, Aiden Corvin, Benedicto Crespo-Facorro, Joanne E Curran, Michael Czisch, Anders M Dale, Gareth E Davies, Eco J C De Geus, Philip L De Jager, Greig I de Zubicaray, Norman Delanty, Chantal Depondt, Anita L DeStefano, Allissa Dillman, Srdjan Djurovic, Gary Donohoe, Wayne C Drevets, Ravi Duggirala, Thomas D Dyer, Susanne Erk, Thomas Espeseth, Denis A Evans, Iryna O Fedko, Guillén Fernández, Luigi Ferrucci, Simon E Fisher, Debra A Fleischman, Ian Ford, Tatiana M Foroud, Peter T Fox, Clyde Francks, Masaki Fukunaga, J Raphael Gibbs, David C Glahn, Randy L Gollub, Harald H H Göring, Hans J Grabe, Robert C Green, Oliver Gruber, Vilmundur Gudnason, Sebastian Guelfi, Narelle K Hansell, John Hardy, Catharina A Hartman, Ryota Hashimoto, Katrin Hegenscheid, Andreas Heinz, Stephanie Le Hellard, Dena G Hernandez, Dirk J Heslenfeld, Beng-Choon Ho, Pieter J Hoekstra, Wolfgang Hoffmann, Albert Hofman, Florian Holsboer, Georg Homuth, Norbert Hosten, Jouke-Jan Hottenga, Hilleke E Hulshoff Pol, Masashi Ikeda, M Kamran Ikram, Clifford R Jack, Mark Jenkinson, Robert Johnson, Erik G Jönsson, J Wouter Jukema, René S Kahn, Ryota Kanai, Iwona Kloszewska, David S Knopman, Peter Kochunov, John B Kwok, Stephen M Lawrie, Hervé Lemaître, Xinmin Liu, Dan L Longo, W T Longstreth, Oscar L Lopez, Simon Lovestone, Oliver Martinez, Jean-Luc Martinot, Venkata S Mattay, Colm McDonald, Andrew M McIntosh, Katie L McMahon, Francis J McMahon, Patrizia Mecocci, Ingrid Melle, Andreas Meyer-Lindenberg, Sebastian Mohnke, Grant W Montgomery, Derek W Morris, Thomas H Mosley, Thomas W Mühleisen, Bertram Müller-Myhsok, Michael A Nalls, Matthias Nauck, Thomas E Nichols, Wiro J Niessen, Markus M Nöthen, Lars Nyberg, Kazutaka Ohi, Rene L Olvera, Roel A Ophoff, Massimo Pandolfo, Tomas Paus, Zdenka Pausova, Brenda W J H Penninx, G Bruce Pike, Steven G Potkin, Bruce M Psaty, Simone Reppermund, Marcella Rietschel, Joshua L Roffman, Nina Romanczuk-Seiferth, Jerome I Rotter, Mina Ryten, Ralph L Sacco, Perminder S Sachdev, Andrew J Saykin, Reinhold Schmidt, Peter R Schofield, Sigurdur Sigurdsson, Andy Simmons, Andrew Singleton, Sanjay M Sisodiya, Colin Smith, Jordan W Smoller, Hilkka Soininen, Velandai Srikanth, Vidar M Steen, David J Stott, Jessika E Sussmann, Anbupalam Thalamuthu, Henning Tiemeier, Arthur W Toga, Bryan J Traynor, Juan Troncoso, Jessica A Turner, Christophe Tzourio, Andre G Uitterlinden, Maria C Valdés Hernández, Marcel Van der Brug, Aad Van der Lugt, Nic J A Van der Wee, Cornelia M Van Duijn, Neeltje E M Van Haren, Dennis Van T Ent, Marie-Jose Van Tol, Badri N Vardarajan, Dick J Veltman, Meike W Vernooij, Henry Völzke, Henrik Walter, Joanna M Wardlaw, Thomas H Wassink, Michael E Weale, Daniel R Weinberger, Michael W Weiner, Wei Wen, Eric Westman, Tonya White, Tien Y Wong, Clinton B Wright, H Ronald Zielke, Alan B Zonderman, Ian J Deary, Charles DeCarli, Helena Schmidt, Nicholas G Martin, Anton J M De Craen, Margaret J Wright, Lenore J Launer, Gunter Schumann, Myriam Fornage, Barbara Franke, Stéphanie Debette, Sarah E Medland, M Arfan Ikram, Paul M Thompson
Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438 adults, we discovered five previously unknown loci for intracranial volume and confirmed two known signals. Four of the loci were also associated with adult human stature, but these remained associated with intracranial volume after adjusting for height...
December 2016: Nature Neuroscience
https://www.readbyqxmd.com/read/27687309/quantitative-proteomic-analysis-of-her2-expression-in-the-selection-of-gastric-cancer-patients-for-trastuzumab-treatment
#8
E An, C-Y Ock, T-Y Kim, K-H Lee, S-W Han, S-A Im, T-Y Kim, W-L Liao, F Cecchi, A Blackler, S Thyparambil, W H Kim, J Burrows, T Hembrough, D Catenacci, D-Y Oh, Y-J Bang
BACKGROUND: A wide range of response rates have been reported in HER2-positive gastric cancer (GC) patients treated with trastuzumab. Other HER2-targeted therapies for GC have yet to show efficacy in clinical trials. These findings raise question about the ability of standard HER2 diagnostics to accurately distinguish between GC patients who would and would not benefit from anti-HER2 therapies. PATIENTS AND METHODS: GC patients (n=237), including a subset from the Trastuzumab in GC (ToGA) trial were divided into 3 groups based on HER2 status and history of treatment with standard chemotherapy or chemotherapy plus trastuzumab...
September 29, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27678040/reproductive-outcomes-of-familial-oocyte-donation
#9
Joseph Hasson, Togas Tulandi, Weon-Yong Son, Na'ama Al Ma'mari, Ahmad Badeghiesh, Sammer Tannus, Janet Takefman, Tal Shavit
OBJECTIVE: Oocyte donation (OD) from a family member may be more available to patients. Our objective was to compare reproductive outcomes of familial OD with those of unrelated OD. DESIGN: Retrospective cohort study in a single university-affiliated center. SETTING: Not applicable. PATIENT(S): Four hundred thirty OD cycles performed from 2010 to 2014: 124 from family members and 306 from unrelated donors. INTERVENTION(S): None...
December 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27650471/distension-of-the-toga-of-thermotoga-maritima-involves-continued-growth-of-the-outer-envelope-as-cells-enter-the-stationary-phase
#10
Chaman Ranjit, Kenneth M Noll
Thermotoga maritima cells are distinguished by a sheath-like structure called the toga that loosely encloses single or multiple cells. During growth, and particularly at late phases of population growth, the toga distends from the poles of many cells. Little is known about this phenomenon so this study presents basic information about this process. We first provide quantitative data demonstrating that cells showing toga distensions increase in number during growth and that the phenomenon is not due to acidification of their growth medium...
October 2016: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/27604809/weight-gain-over-3%C3%A2-kg-is-associated-with-worse-metabolic-syndrome-indicators-regardless-of-weight-gain-recognition-in-japanese-workers
#11
Shiori Toga, Yuko Fukkoshi, Rie Akamatsu
We examined the relationship between recognition of a 3-kg weight gain in 1 year with metabolic syndrome parameters and lifestyle status related to metabolic syndrome or cardiovascular disease in Japanese workers. Data were collected twice between April 2009 and March 2011, and self-reported questionnaires were completed at a follow-up by 275 workers who gained more than 3 kg in 1 year. This study showed that ~40 per cent of those who gained more than 3 kg in a year did not recognise their weight gain, and a weight gain over 3 kg was associated with worse metabolic syndrome parameters regardless of weight gain recognition...
September 7, 2016: Journal of Health Psychology
https://www.readbyqxmd.com/read/27601246/marinitoga-arctica-sp-nov-a-thermophilic-anaerobic-heterotroph-isolated-from-the-soria-moria-vent-field-on-the-arctic-mid-ocean-ridge
#12
Bjørn O Steinsbu, Victoria Røyseth, Ingunn H Thorseth, Ida H Steen
A thermophilic, anaerobic, heterotrophic bacterium, designated 2PyrY55-1T, was isolated from the wall of an active hydrothermal white-smoker chimney in the Soria Moria vent field (71 °N) at the Mohns Ridge in the Norwegian-Greenland Sea. Cells of the strain were Gram-negative, motile rods that possessed a polar flagellum and a sheath-like outer structure ('toga'). Growth was observed at 45-70 °C (optimum 65 °C), pH 5.0-7.5 (optimum pH 5.5) and in 1.5-5.5 % NaCl (optimum 2.5 %). The strain grew on pyruvate, complex proteinaceous substrates, and various sugars...
September 5, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27597294/phenotypic-and-genetic-correlations-between-the-lobar-segments-of-the-inferior-fronto-occipital-fasciculus-and-attention
#13
Yuan Leng, Yonggang Shi, Qiaowen Yu, John Darrell Van Horn, Haiyan Tang, Junning Li, Wenjian Xu, Xinting Ge, Yuchun Tang, Yan Han, Dong Zhang, Min Xiao, Huaqiang Zhang, Zengchang Pang, Arthur W Toga, Shuwei Liu
Attention deficits may present dysfunctions in any one or two components of attention (alerting, orienting, and executive control (EC)). However, these various forms of attention deficits generally have abnormal microstructure integrity of inferior fronto-occipital fasciculus (IFOF). In this work, we aim to deeply explore: (1) associations between microstructure integrities of IFOF (including frontal, parietal, temporal, occipital, and insular segments) and attention by means of structural equation models and multiple regression analyses; (2) genetic/environmental effects on IFOF, attention, and their correlations using bivariate genetic analysis...
September 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27535542/integration-of-bioinformatics-and-imaging-informatics-for-identifying-rare-psen1-variants-in-alzheimer-s-disease
#14
Kwangsik Nho, Emrin Horgusluoglu, Sungeun Kim, Shannon L Risacher, Dokyoon Kim, Tatiana Foroud, Paul S Aisen, Ronald C Petersen, Clifford R Jack, Leslie M Shaw, John Q Trojanowski, Michael W Weiner, Robert C Green, Arthur W Toga, Andrew J Saykin
BACKGROUND: Pathogenic mutations in PSEN1 are known to cause familial early-onset Alzheimer's disease (EOAD) but common variants in PSEN1 have not been found to strongly influence late-onset AD (LOAD). The association of rare variants in PSEN1 with LOAD-related endophenotypes has received little attention. In this study, we performed a rare variant association analysis of PSEN1 with quantitative biomarkers of LOAD using whole genome sequencing (WGS) by integrating bioinformatics and imaging informatics...
2016: BMC Medical Genomics
https://www.readbyqxmd.com/read/27525159/constructing-a-real-time-prescription-drug-monitoring-system
#15
Young-Taek Park, Youn Tae Lee, Emmanuel C Jo
OBJECTIVES: The objective of this investigation was to demonstrate the possibility of the construction of a real-time prescription drug monitoring system (PDMOS) using data from the nationwide Drug Utilization Review (DUR) system in Korea. METHODS: The DUR system collects information on drug prescriptions issued by healthcare practitioners and on drugs dispensed by pharmacies. PDMOS was constructed using this data. The screen of PDMOS is designed to exhibit the number of drug prescriptions, the number of prescriptions dispensed by pharmacies, and the dispensed prescription drug costs on a daily and weekly basis...
July 2016: Healthcare Informatics Research
https://www.readbyqxmd.com/read/27494614/predictive-big-data-analytics-a-study-of-parkinson-s-disease-using-large-complex-heterogeneous-incongruent-multi-source-and-incomplete-observations
#16
Ivo D Dinov, Ben Heavner, Ming Tang, Gustavo Glusman, Kyle Chard, Mike Darcy, Ravi Madduri, Judy Pa, Cathie Spino, Carl Kesselman, Ian Foster, Eric W Deutsch, Nathan D Price, John D Van Horn, Joseph Ames, Kristi Clark, Leroy Hood, Benjamin M Hampstead, William Dauer, Arthur W Toga
BACKGROUND: A unique archive of Big Data on Parkinson's Disease is collected, managed and disseminated by the Parkinson's Progression Markers Initiative (PPMI). The integration of such complex and heterogeneous Big Data from multiple sources offers unparalleled opportunities to study the early stages of prevalent neurodegenerative processes, track their progression and quickly identify the efficacies of alternative treatments. Many previous human and animal studies have examined the relationship of Parkinson's disease (PD) risk to trauma, genetics, environment, co-morbidities, or life style...
2016: PloS One
https://www.readbyqxmd.com/read/27393285/emerging-manifestations-of-cesarean-scar-defect-in-reproductive-aged-women
#17
REVIEW
Togas Tulandi, Aviad Cohen
The objective of this study was to evaluate the prevalence of cesarean scar defects and its clinical manifestations in reproductive-aged women. We performed a systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement using keywords of "cesarean scar defect, uterine scar defect, uterine diverticulum niche, isthmocele, pouch, or sacculation" and their combination. Thirty-two trials met the inclusion criteria. Cesarean scar defects are commonly found on ultrasound examination (24%-88%)...
September 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27322419/the-mouse-cortico-striatal-projectome
#18
Houri Hintiryan, Nicholas N Foster, Ian Bowman, Maxwell Bay, Monica Y Song, Lin Gou, Seita Yamashita, Michael S Bienkowski, Brian Zingg, Muye Zhu, X William Yang, Jean C Shih, Arthur W Toga, Hong-Wei Dong
Different cortical areas are organized into distinct intracortical subnetworks. The manner in which descending pathways from the entire cortex interact subcortically as a network remains unclear. We developed an open-access comprehensive mesoscale mouse cortico-striatal projectome: a detailed connectivity projection map from the entire cerebral cortex to the dorsal striatum or caudoputamen (CP) in rodents. On the basis of these projections, we used new computational neuroanatomical tools to identify 29 distinct functional striatal domains...
August 2016: Nature Neuroscience
https://www.readbyqxmd.com/read/27251446/predictive-biomarkers-for-targeted-and-cytotoxic-agents-in-gastric-cancer-for-personalized-medicine
#19
Shalong Wang, Lianwen Yuan
Gastric cancer (GC) is the fourth most common cancer and the second leading cause of cancer. The treatment of GC remains challenging as the outcomes achieved with surgery alone or adjuvant or neoadjuvant chemotherapy and radiotherapy are relatively poor. New treatment strategies are emerging and are being tested in solid tumors including GC. Over the past few years, the treatment of metastatic colorectal cancer (CRC) has made great advances, but strategies to manage GC have improved little. Multiple drug resistance is common in GC chemotherapy and targeted therapy; some patients appear to receive treatment that is suboptimal or even inefficacious...
July 19, 2016: Bioscience Trends
https://www.readbyqxmd.com/read/27238610/in-vitro-evaluation-of-surgical-helmet-systems-for-protecting-surgeons-from-droplets-generated-during-orthopaedic-procedures
#20
R Wendlandt, M Thomas, B Kienast, A P Schulz
BACKGROUND: Operating theatres and surgical clothing are designed to protect the patient from surgical site infections. However, there is still a risk of infection of the surgical team with blood-borne pathogens via ocular or mucocutaneous exposure. Whereas conventional surgical clothing provides some protection against contamination, surgical helmet systems (SHS) are intended to provide a high level of protection by forming a barrier for particles, aerosols and fluids between surgeon and surgical field of work...
September 2016: Journal of Hospital Infection
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