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https://www.readbyqxmd.com/read/29762762/coulomb-and-ch-%C3%AF-interactions-in-6-4-photolyase-dna-complex-dominate-dna-binding-and-repair-abilities
#1
Yuma Terai, Ryuma Sato, Takahiro Yumiba, Ryuhei Harada, Kohei Shimizu, Tatsuya Toga, Tomoko Ishikawa-Fujiwara, Takeshi Todo, Shigenori Iwai, Yasuteru Shigeta, Junpei Yamamoto
(6-4) Photolyases ((6-4)PLs) are flavoenzymes that repair the carcinogenic UV-induced DNA damage, pyrimidine(6-4)pyrimidone photoproducts ((6-4)PPs), in a light-dependent manner. Although the reaction mechanism of DNA photorepair by (6-4)PLs has been intensively investigated, the molecular mechanism of the lesion recognition remains obscure. We show that a well-conserved arginine residue in Xenopus laevis (6-4)PL (Xl64) participates in DNA binding, through Coulomb and CH-π interactions. Fragment molecular orbital calculations estimated attractive interaction energies of -80-100 kcal mol-1 for the Coulomb interaction and -6 kcal mol-1 for the CH-π interaction, and the loss of either of them significantly reduced the affinity for (6-4)PP-containing oligonucleotides, as well as the quantum yield of DNA photorepair...
May 14, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29758363/different-surgical-approaches-to-313-cesarean-scar-pregnancies
#2
Aiwen Le, Mengxi Li, YaHong Xu, Zhonghai Wang, Xiao Yun Dai, Tian Hui Xiao, Rong Zhuo, Rui Yuan, Togas Tulandi
STUDY OBJECTIVE: To evaluate the efficacy of different surgical treatments for cesarean scar pregnancy (CSP). DESIGN: Retrospective study (Canadian Task Force classification II-3). SETTING: Affiliated university hospitals. PATIENTS: 313 patients with CSP. INTERVENTIONS: Dilation and curettage under ultrasound guidance (DCUS, n = 124), dilation and curettage with hysteroscopic guidance (DCH, n = 103), vaginal excision (n = 55), laparotomy (n = 12), and laparoscopy (n = 19)...
May 11, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29663135/when-tractography-meets-tracer-injections-a-systematic-study-of-trends-and-variation-sources-of-diffusion-based-connectivity
#3
Dogu Baran Aydogan, Russell Jacobs, Stephanie Dulawa, Summer L Thompson, Maite Christi Francois, Arthur W Toga, Hongwei Dong, James A Knowles, Yonggang Shi
Tractography is a powerful technique capable of non-invasively reconstructing the structural connections in the brain using diffusion MRI images, but the validation of tractograms is challenging due to lack of ground truth. Owing to recent developments in mapping the mouse brain connectome, high-resolution tracer injection-based axonal projection maps have been created and quickly adopted for the validation of tractography. Previous studies using tracer injections mainly focused on investigating the match in projections and optimal tractography protocols...
April 16, 2018: Brain Structure & Function
https://www.readbyqxmd.com/read/29587846/evaluation-of-two-dna-extraction-methods-for-the-pcr-based-detection-of-eukaryotic-enteric-pathogens-in-fecal-samples
#4
Estelle Menu, Charles Mary, Isabelle Toga, Didier Raoult, Stéphane Ranque, Fadi Bittar
OBJECTIVE: Efficient and easy-to-use DNA extraction and purification methods are critical in implementing PCR-based diagnosis of pathogens. In order to optimize the routine clinical laboratory diagnosis of eukaryotic enteric pathogens, we compare, via quantitative PCR cycle threshold (Ct) values, the efficiency of two DNA extraction kits: the semi-automated EZ1® (Qiagen) and the manual QIAamp® DNA Stool Mini Kit (Qiagen), on six protozoa: Blastocystis spp., Cryptosporidium parvum/hominis, Cyclospora cayetanensis, Dientamoeba fragilis, Giardia intestinalis and Cystoisospora belli and one microsporidia: Enterocytozoon bieneusi...
March 27, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29572948/longitudinal-change-of-clinical-and-biological-measures-in-early-parkinson-s-disease-parkinson-s-progression-markers-initiative-cohort
#5
Tanya Simuni, Andrew Siderowf, Shirley Lasch, Chris S Coffey, Chelsea Caspell-Garcia, Danna Jennings, Caroline M Tanner, John Q Trojanowski, Leslie M Shaw, John Seibyl, Norbert Schuff, Andrew Singleton, Karl Kieburtz, Arthur W Toga, Brit Mollenhauer, Doug Galasko, Lana M Chahine, Daniel Weintraub, Tatiana Foroud, Duygu Tosun, Kathleen Poston, Vanessa Arnedo, Mark Frasier, Todd Sherer, Sohini Chowdhury, Kenneth Marek
OBJECTIVE: The objective of this study was to assess longitudinal change in clinical and dopamine transporter imaging outcomes in early, untreated PD. METHODS: We describe 5-year longitudinal change of the MDS-UPDRS and other clinical measures using results from the Parkinson's Progression Markers Initiative, a longitudinal cohort study of early Parkinson's disease (PD) participants untreated at baseline. We also provide data on the longitudinal change in dopamine transporter 123-I Ioflupane striatal binding and correlation between the 2 measures...
March 23, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29570013/value-of-pituitary-gland-mri-at-7-t-in-cushing-s-disease-and-relationship-to-inferior-petrosal-sinus-sampling-case-report
#6
Meng Law, Regina Wang, Chia-Shang J Liu, Mark S Shiroishi, John D Carmichael, William J Mack, Martin Weiss, Danny J J Wang, Arthur W Toga, Gabriel Zada
Cushing's disease is caused by adrenocorticotrophic hormone (ACTH)-secreting pituitary adenomas, which are often difficult to identify on standard 1.5-T or 3-T MRI, including dynamic contrast imaging. Inferior petrosal and cavernous sinus sampling remains the gold standard for MRI-negative Cushing's disease. The authors report on a 27-year-old woman with Cushing's disease in whom the results of standard 1.5-T and 3-T MRI, including 1.5-T dynamic contrast imaging, were negative. Inferior petrosal sinus sampling showed a high central-to-peripheral ACTH ratio (148:1) as well as a right-to-left ACTH gradient (19:1), suggesting a right-sided pituitary microadenoma...
March 23, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29468698/systematic-review-non-a-e-seronegative-or-indeterminate-hepatitis-what-is-this-deadly-disease
#7
REVIEW
P N Brennan, M C Donnelly, K J Simpson
BACKGROUND: A significant proportion of cases of acute liver failure (ALF) do not have an identifiable cause; so called "non A-E," "non A, non B, non C," "seronegative" or "indeterminate" hepatitis. However, this entity is clinically not well described. AIM: To collate the known incidence and outcomes in indeterminate hepatitis. This systematic review sought to identify potential aetiologies that ought to be considered, and identify likely future objectives in classification and treatment strategies for indeterminate hepatitis...
April 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29451302/comparing-cytotoxic-backbones-for-first-line-trastuzumab-containing-regimens-in-human-epidermal-growth-factor-receptor-2-positive-advanced-oesophagogastric-cancer-a-meta-analysis
#8
Emil Ter Veer, Aafke Creemers, Laura de Waal, Martijn G H van Oijen, Hanneke W M van Laarhoven
According to the Trastuzumab for Gastric Cancer (ToGA) study, trastuzumab plus cisplatin and capecitabine/5-fluorouracil (5-FU) is standard first-line treatment for human epidermal growth factor receptor 2 (HER2)-positive advanced oesophagogastric cancer. We examined the relative efficacy and safety of alternative trastuzumab-based cytotoxic backbone regimens compared to the standard ToGA regimen using meta-analysis. We searched Medline, EMBASE, CENTRAL and ASCO and ESMO up to March 2017 for studies investigating alternative first-line trastuzumab-based regimens for HER2-positive oesophagogastric cancer, defined as high protein expression IHC3+ or IHC2+ and gene amplification by in situ hybridisation...
February 16, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29447704/l-importance-d-%C3%A3-carter-l-existence-d-une-corne-ut%C3%A3-rine-rudimentaire-chez-les-femmes-pr%C3%A3-sentant-un-ut%C3%A3-rus-unicorne
#9
EDITORIAL
Megan Schneiderman, Togas Tulandi
No abstract text is available yet for this article.
February 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29447703/the-importance-to-exclude-the-existence-of-a-rudimentary-uterine-horn-in-women-with-unicornuate-uterus
#10
EDITORIAL
Megan Schneiderman, Togas Tulandi
No abstract text is available yet for this article.
February 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29445429/classification-of-mri-and-psychological-testing-data-based-on-support-vector-machine
#11
Wenlu Yang, Xinyun Chen, David S Cohen, Eric R Rosin, Arthur W Toga, Paul M Thompson, Xudong Huang
Alzheimer's disease (AD) is a progressive, and often fatal, brain disease that causes neurodegeneration, resulting in memory loss as well as other cognitive and behavioral problems. Here, we propose a novel multimodal method combining independent components from MRI measures and clinical assessments to distinguish Alzheimer's patients or mild cognitive impairment (MCI) subjects from healthy elderly controls. 70 AD subjects (mean age: 77.15 ± 6.2 years), 98 MCI subjects (mean age: 76.91 ± 5.7 years), and 150 HC subjects (mean age: 75...
December 2017: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29430233/durable-and-complete-response-to-herceptin-monotherapy-in-patients-with-metastatic-gastroesophageal-cancer
#12
Brenen P Swofford, Tomislav Dragovich
Gastroesophageal cancer is the sixth leading cause of cancer-related death worldwide. The 2 most common histologies are squamous cell carcinoma and adenocarcinoma, which has seen an increase in incidence correlating with an increase in obesity in developed countries. Gastroesophageal adenocarcinoma has a preponderance to metastasize early, making it a highly lethal cancer with a low 5-year survival rate of ∼15-25%. Therefore, for the majority of patients, treatment focuses on palliation and prolongation of survival...
September 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/29423789/do-trained-reproductive-endocrinologists-perform-better-than-their-trainees-comparing-clinical-pregnancy-rates-and-live-birth-rates-after-transfer-of-single-fresh-blastocysts
#13
Sadikah Behbehani, Joseph Hasson, Stefano Polesello, W Y Son, Togas Tulandi, William Buckett
PURPOSE: To compare clinical pregnancy rates and live birth rates of single blastocyst transfers performed by attending physicians or fellows in reproductive endocrinology and infertility program. METHODS: Retrospective study in an academic reproductive center. We evaluated 932 fresh single blastocyst transfer cycles performed by fellows in training (389 embryo transfers) and by attending physicians (543 embryo transfers). RESULTS: There were no differences in the baseline characteristics and IVF cycle parameters between patients who had transfers performed by fellows or attending physicians...
February 9, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29414494/neuroanatomical-morphometric-characterization-of-sex-differences-in-youth-using-statistical-learning
#14
Farshid Sepehrband, Kirsten M Lynch, Ryan P Cabeen, Clio Gonzalez-Zacarias, Lu Zhao, Mike D'Arcy, Carl Kesselman, Megan M Herting, Ivo D Dinov, Arthur W Toga, Kristi A Clark
Exploring neuroanatomical sex differences using a multivariate statistical learning approach can yield insights that cannot be derived with univariate analysis. While gross differences in total brain volume are well-established, uncovering the more subtle, regional sex-related differences in neuroanatomy requires a multivariate approach that can accurately model spatial complexity as well as the interactions between neuroanatomical features. Here, we developed a multivariate statistical learning model using a support vector machine (SVM) classifier to predict sex from MRI-derived regional neuroanatomical features from a single-site study of 967 healthy youth from the Philadelphia Neurodevelopmental Cohort (PNC)...
May 15, 2018: NeuroImage
https://www.readbyqxmd.com/read/29400417/brain-structure-differences-between-chinese-and-caucasian-cohorts-a-comprehensive-morphometry-study
#15
Yuchun Tang, Lu Zhao, Yunxia Lou, Yonggang Shi, Rui Fang, Xiangtao Lin, Shuwei Liu, Arthur Toga
Numerous behavioral observations and brain function studies have demonstrated that neurological differences exist between East Asians and Westerners. However, the extent to which these factors relate to differences in brain structure is still not clear. As the basis of brain functions, the anatomical differences in brain structure play a primary and critical role in the origination of functional and behavior differences. To investigate the underlying differences in brain structure between the two cultural/ethnic groups, we conducted a comparative study on education-matched right-handed young male adults (age = 22-29 years) from two cohorts, Han Chinese (n = 45) and Caucasians (n = 45), using high-dimensional structural magnetic resonance imaging (MRI) data...
May 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29389750/18f-florbetapir-positron-emission-tomography-determined-cerebral-%C3%AE-amyloid-deposition-and-neurocognitive-performance-after-cardiac-surgery
#16
Rebecca Y Klinger, Olga G James, Salvador Borges-Neto, Tiffany Bisanar, Yi-Ju Li, Wenjing Qi, Miles Berger, Niccolò Terrando, Mark F Newman, P Murali Doraiswamy, Joseph P Mathew
BACKGROUND: Amyloid deposition is a potential contributor to postoperative cognitive dysfunction. The authors hypothesized that 6-week global cortical amyloid burden, determined by F-florbetapir positron emission tomography, would be greater in those patients manifesting cognitive dysfunction at 6 weeks postoperatively. METHODS: Amyloid deposition was evaluated in cardiac surgical patients at 6 weeks (n = 40) and 1 yr (n = 12); neurocognitive function was assessed at baseline (n = 40), 6 weeks (n = 37), 1 yr (n = 13), and 3 yr (n = 9)...
April 2018: Anesthesiology
https://www.readbyqxmd.com/read/29380470/hemispheric-asymmetries-in-the-orientation-and-location-of-the-lateral-geniculate-nucleus-in-dyslexia
#17
Mónica Giraldo-Chica, Keith A Schneider
Human brain asymmetry reflects normal specialization of functional roles and may derive from evolutionary, hereditary, developmental, experiential, and pathological factors (Toga & Thompson, 2003). Geschwind and Galaburda (1985) suggested that processing difficulties in dyslexia are due to structural differences between hemispheres. Because of its potential significance to the controversial magnocellular theory of dyslexia, we investigated hemispheric differences in the human lateral geniculate nucleus (LGN), the primary visual relay and control nucleus in the thalamus, in subjects with dyslexia compared to normal readers...
January 29, 2018: Dyslexia: the Journal of the British Dyslexia Association
https://www.readbyqxmd.com/read/29360425/the-use-of-home-brew-in-pacific-islands-countries-and-territories
#18
Vili Nosa, Shavonne Duffy, Debbie Singh, Save Lavelio, Uma Amber, Avanoa Homasi-Paelate, Julia Alfred
This review examines what is known about the production and use of home brew in the Pacific Islands countries and territories. Data collection involved interviews of 78 men and women from the Marshall Islands, Papua New Guinea, Toga, and Tuvalu. The interviews were conducted in 2013 by local interviewers. The questions fell into four key areas: people's history of home-brew consumption, the reasons for home-brew use, the effects of home brew, and people's perceptions about home brew. An open ethnographic approach revealed that males are the main consumers of home brew, that home brew is consumed in private venues by those with low socioeconomic status, and that there are positive and negative outcomes associated with the use of home brew...
January 2018: Journal of Ethnicity in Substance Abuse
https://www.readbyqxmd.com/read/29324607/effect-of-cesarean-delivery-on-long-term-risk-of-small-bowel-obstruction
#19
Haim A Abenhaim, Togas Tulandi, Machelle Wilchesky, Robert Platt, Andrea R Spence, Nicholas Czuzoj-Shulman, Samy Suissa
OBJECTIVE: To evaluate the association of cesarean deliveries on the incidence of small bowel obstruction. METHODS: We formed a population-based cohort of all women with a first live birth between 1998 and 2007 using the U.K. Clinical Practice Research Datalink. Women were followed until 2015, the occurrence of a small bowel obstruction, or loss to follow-up. Cesarean delivery was identified from the Hospital Episode Statistics and small bowel obstruction events were identified using the Classification of Interventions and Procedures and International Classification of Diseases, 10th Revision codes...
February 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29290024/a-multi-institution-phase-ii-study-of-docetaxel-and-s-1-in-combination-with-trastuzumab-for-her2-positive-advanced-gastric-cancer-dash-study
#20
Shunsuke Kagawa, Atsushi Muraoka, Takeshi Kambara, Hiroshi Nakayama, Ryosuke Hamano, Norimitsu Tanaka, Kazuhiro Noma, Kohji Tanakaya, Hiroyuki Kishimoto, Kunitoshi Shigeyasu, Shinji Kuroda, Satoru Kikuchi, Kazuya Kuwada, Masahiko Nishizaki, Yasuhiro Shirakawa, Toshiyoshi Fujiwara
BACKGROUND: Trastuzumab when combined with fluoropyrimidine and cisplatin was proven to improve survival in patients with human epidermal growth factor receptor 2 (HER2)-positive gastric cancer (GC) in the ToGA study. The safety and efficacy of trastuzumab in combination with docetaxel and S-1 have not yet been evaluated. METHODS: This study was a multicenter, phase II study. Patients with chemotherapy-naïve HER2-positive advanced or metastatic GC were eligible...
February 2018: Cancer Chemotherapy and Pharmacology
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