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https://www.readbyqxmd.com/read/28936560/multicenter-phase-ii-study-of-trastuzumab-plus-s-1-alone-in-elderly-patients-with-her2-positive-advanced-gastric-cancer-jaccro-gc-06
#1
Yutaka Kimura, Masashi Fujii, Toshiki Masuishi, Kazuhiro Nishikawa, Chikara Kunisaki, Satoshi Matsusaka, Yoshihiko Segawa, Masato Nakamura, Kinro Sasaki, Narutoshi Nagao, Yukimasa Hatachi, Yasuhiko Yuasa, Shinya Asami, Masahiro Takeuchi, Hiroshi Furukawa, Toshifusa Nakajima
BACKGROUND: S-1 plus cisplatin is a standard regimen for advanced gastric cancer (AGC) in Asia. The ToGA trial established a fluoropyrimidine plus cisplatin and trastuzumab as a standard treatment for human epidermal growth factor receptor 2 (HER2)-positive AGC. In the HERBIS-1 trial, trastuzumab combined with S-1 plus cisplatin showed promising antitumor activity in patients with HER2-positive AGC. However, cisplatin has several important drawbacks, including vomiting and renal toxicity...
September 21, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/28865548/effects-of-adenomyosis-on-in%C3%A2-vitro-fertilization-treatment-outcomes-a-meta-analysis
#2
Grace Younes, Togas Tulandi
OBJECTIVE: To systematically review and summarize the existing evidence related to the effect of adenomyosis on fertility and on in vitro fertilization (IVF) clinical outcomes, and to explore the effects of surgical or medical treatments. DESIGN: Meta-analysis. SETTING: Not applicable. PATIENT(S): An electronic-based search was performed with the use of the following databases: Pubmed, Embase, Ovid Medline, Cochrane Central Register of Controlled Trials, and Google Scholar, identifying all related articles up to November 2016...
September 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28859761/quand-le-clomiph%C3%A3-ne-ne-sera-plus-offert%C3%A2
#3
EDITORIAL
Togas Tulandi, Robert Casper
No abstract text is available yet for this article.
September 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28859760/when-clomiphene-is-no-longer-available%C3%A2
#4
EDITORIAL
Togas Tulandi, Robert Casper
No abstract text is available yet for this article.
September 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28846757/apolipoprotein-e-genotype-and-sex-risk-factors-for-alzheimer-disease-a-meta-analysis
#5
Scott C Neu, Judy Pa, Walter Kukull, Duane Beekly, Amanda Kuzma, Prabhakaran Gangadharan, Li-San Wang, Klaus Romero, Stephen P Arneric, Alberto Redolfi, Daniele Orlandi, Giovanni B Frisoni, Rhoda Au, Sherral Devine, Sanford Auerbach, Ana Espinosa, Mercè Boada, Agustín Ruiz, Sterling C Johnson, Rebecca Koscik, Jiun-Jie Wang, Wen-Chuin Hsu, Yao-Liang Chen, Arthur W Toga
Importance: It is unclear whether female carriers of the apolipoprotein E (APOE) ε4 allele are at greater risk of developing Alzheimer disease (AD) than men, and the sex-dependent association of mild cognitive impairment (MCI) and APOE has not been established. Objective: To determine how sex and APOE genotype affect the risks for developing MCI and AD. Data Sources: Twenty-seven independent research studies in the Global Alzheimer's Association Interactive Network with data on nearly 58 000 participants...
August 28, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28750299/prolonged-activation-of-the-coagulation-system-during-in-vitro-fertilization-cycles
#6
Yoni Cohen, Togas Tulandi, Benny Almog, Eyal Zohav, Varda Deutsch, Ariel Many, Ami Amit, Aviad Cohen
OBJECTIVE: To investigate coagulation system changes during an in-vitro fertilization (IVF) cycle using Thromboelastogram (TEG) that enables analysis of the elastic properties of whole blood samples and provides a global assessment of the hemostatic function. STUDY DESIGN: A prospective study. TEG indices were evaluated in 23 women who underwent controlled ovarian stimulation for IVF at four points in time: 1. At the beginning of the cycle (corresponding to the lowest levels of E2), 2...
July 17, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28739414/conservative-surgery-for-adenomyosis-and-results-a-systematic-review
#7
REVIEW
Grace Younes, Togas Tulandi
The traditional treatment for women with symptomatic adenomyosis is hysterectomy. However, reproductive aged women should be managed with less invasive treatments including medical treatment. For patients who are refractory or unsuitable to long term medical treatment, or those with focal adenomyoma, conservative surgeries could be offered. The objective of our study was to review available conservative surgeries for the treatment of adenomyosis, their complications, and the rates of success and recurrence...
July 21, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28678890/platinum-sensitive-2-like-impacts-growth-root-morphology-seed-set-and-stress-responses
#8
Amr R A Kataya, Maria T Creighton, Toga P Napitupulu, Christine Sætre, Behzad Heidari, Peter Ruoff, Cathrine Lillo
Eukaryotic protein phosphatase 4 (PP4) is a PP2A-type protein phosphatase that is part of a conserved complex with regulatory factors PSY2 and PP4R2. Various lines of Arabidopsis thaliana with mutated PP4 subunit genes were constructed to study the so far completely unknown functions of PP4 in plants. Mutants with knocked out putative functional homolog of the PSY2 LIKE (PSY2L) gene were dwarf and bushy, while plants with knocked out PP4R2 LIKE (PP4R2L) looked very similar to WT. The psy2l seedlings had short roots with disorganized morphology and impaired meristem...
2017: PloS One
https://www.readbyqxmd.com/read/28647447/dienogest-therapy-as-a-treatment-for-catamenial-pneumothorax-case-report-and-review-of-hormonal-options
#9
Shifana Lalani, Amanda Black, Meryl C Hodge, Togas Tulandi, Innie Chen
BACKGROUND: Catamenial pneumothorax is a rare but serious condition for women of reproductive age. We describe a trial of dienogest as hormonal therapy for catamenial pneumothorax and review the literature on hormonal suppressive therapy for this condition. CASE: A 39-year-old female, gravida 0 para 0, presented with recurrent pneumothoraces coinciding with her menses. After surgical therapy, she was started on leuprolide acetate injections for 6 months to reduce recurrence...
June 21, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28625759/predictive-value-of-serum-hcg-concentrations-in-pregnancies-achieved-after-single-fresh-or-vitrified-warmed-blastocyst-transfer
#10
Galia Oron, Tal Shavit, Efrat Esh-Broder, Son Weon-Young, Togas Tulandi, Hananel Holzer
Possible differences between serum HCG levels in pregnancies achieved after transfer of a single fresh or a vitrified-warmed blastocyst were evaluated. Out of 1130 single blastocyst transfers resulting in positive HCG results, 789 were single fresh blastocyst transfers and 341 single vitrified-warmed blastocyst transfers. The initial serum HCG levels of 869 clinical intrauterine pregnancies were evaluated, 638 after the transfer of a single fresh blastocysts and 231 after the transfer of a single vitrified-warmed blastocysts...
September 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28589856/association-analysis-of-rare-variants-near-the-apoe-region-with-csf-and-neuroimaging-biomarkers-of-alzheimer-s-disease
#11
Kwangsik Nho, Sungeun Kim, Emrin Horgusluoglu, Shannon L Risacher, Li Shen, Dokyoon Kim, Seunggeun Lee, Tatiana Foroud, Leslie M Shaw, John Q Trojanowski, Paul S Aisen, Ronald C Petersen, Clifford R Jack, Michael W Weiner, Robert C Green, Arthur W Toga, Andrew J Saykin
BACKGROUND: The APOE ε4 allele is the most significant common genetic risk factor for late-onset Alzheimer's disease (LOAD). The region surrounding APOE on chromosome 19 has also shown consistent association with LOAD. However, no common variants in the region remain significant after adjusting for APOE genotype. We report a rare variant association analysis of genes in the vicinity of APOE with cerebrospinal fluid (CSF) and neuroimaging biomarkers of LOAD. METHODS: Whole genome sequencing (WGS) was performed on 817 blood DNA samples from the Alzheimer's Disease Neuroimaging Initiative (ADNI)...
May 24, 2017: BMC Medical Genomics
https://www.readbyqxmd.com/read/28579409/sclerotherapy-in-the-management-of-ovarian-endometrioma-systematic-review-and-meta-analysis
#12
REVIEW
Aviad Cohen, Benny Almog, Togas Tulandi
OBJECTIVE: To evaluate the efficacy of sclerotherapy for ovarian endometrioma on the risk of recurrence, clinical symptoms, and reproductive function. DESIGN: Systematic review and meta-analysis. SETTING: Not applicable. PATIENT(S): Patients who underwent sclerotherapy of ovarian endometrioma. INTERVENTION(S): An electronic-based search with the use of Pubmed, Embase, Ovid Medline, Google Scholar, Clinicaltrials...
July 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28577249/progeny-production-in-the-periplasm-of-thermosipho-globiformans
#13
Tomohiko Kuwabara, Kensuke Igarashi
Thermotogales are rod-shaped, Gram-negative, anaerobic, (hyper) thermophiles distinguished by an outer sheath-like toga, which comprises an outer membrane (OM) and an amorphous layer (AL). Thermosipho globiformans bacteria can transform into spheroids with multiple cells concurrently with AL disintegration during early growth; the cell is defined as the cytoplasmic membrane (CM) plus the entity surrounded by the CM. Spheroids eventually produce rapidly moving periplasmic 'progenies' through an unknown mechanism...
July 2017: Extremophiles: Life Under Extreme Conditions
https://www.readbyqxmd.com/read/28547098/obstetrical-and-perinatal-morbidity-and-mortality-among-in-vitro-fertilization-pregnancies-a-population-based-study
#14
Hussein Sabban, Andrew Zakhari, Valerie Patenaude, Togas Tulandi, Haim A Abenhaim
PURPOSE: To compare patient characteristics and obstetrical/neonatal outcomes of in-vitro fertilization (IVF) and spontaneously conceived pregnancies. METHODS: Using the Nationwide Inpatient Sample, we conducted a retrospective cohort study from 2008 to 2011 comparing IVF conceptions to spontaneous ones. Patient characteristics were descriptively compared, and after adjusting for baseline characteristics with logistic regression, obstetrical/neonatal outcomes were also compared...
July 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28508152/detection-of-her2-amplification-in-circulating-tumor-cells-of-her2-negative-gastric-cancer-patients
#15
Yuji Mishima, Satoshi Matsusaka, Keisho Chin, Mariko Mikuniya, Sayuri Minowa, Tomoko Takayama, Harumi Shibata, Ryoko Kuniyoshi, Mariko Ogura, Yasuhito Terui, Nobuyuki Mizunuma, Kiyohiko Hatake
A key to the successful use of targeted cancer therapy is the ability to preselect patients who are likely to benefit from the treatment according to molecular markers. Assessment for predicting therapy response is mostly done using tumor biopsies. However, these might not truly represent all of the patient's malignant cells because of tumor heterogeneity and/or clonal evolution during disease progression. One potential strategy that can complement primary tumor biopsy is the analysis of circulating tumor cells (CTCs)...
May 15, 2017: Targeted Oncology
https://www.readbyqxmd.com/read/28461700/connectome-imaging-for-mapping-human-brain-pathways
#16
Y Shi, A W Toga
With the fast advance of connectome imaging techniques, we have the opportunity of mapping the human brain pathways in vivo at unprecedented resolution. In this article we review the current developments of diffusion magnetic resonance imaging (MRI) for the reconstruction of anatomical pathways in connectome studies. We first introduce the background of diffusion MRI with an emphasis on the technical advances and challenges in state-of-the-art multi-shell acquisition schemes used in the Human Connectome Project...
September 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28438206/exogenous-gene-transfer-of-rab-3-8-small-gtpase-ameliorates-aberrant-lung-surfactant-homeostasis-in-ruby-rats
#17
Kazuhiro Osanai, Keisuke Nakase, Takashi Sakuma, Kazuaki Nishiki, Masafumi Nojiri, Ryo Kato, Masatoshi Saito, Yuki Fujimoto, Shiro Mizuno, Hirohisa Toga
BACKGROUND: Rab(3)8 small GTPase regulates intracellular transport in melanocytes and alveolar type II epithelial cells. Ruby rats carrying Rab(3)8 and other gene mutations exhibit oculocutaneous albinism, bleeding diathesis, and hence, are a rat model of human Hermansky-Pudlak syndrome (HPS). We previously showed that Long Evans Cinnamon (LEC) rats, one strain of the Ruby rats, developed aberrant lung surfactant homeostasis with remarkably enlarged lamellar bodies in alveolar type II cells...
April 24, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28427857/vitrified-warmed-single-embryo-transfers-may-be-associated-with-increased-maternal-complications-compared-with-fresh-single-embryo-transfers
#18
Tal Shavit, Galia Oron, Son Weon-Young, Hananel Holzer, Togas Tulandi
Cryopreservation of embryos allows single-embryo transfer and storage of supernumerary embryos, maximizing cumulative pregnancy rates. The purpose of this retrospective cohort study was to compare pregnancy outcome in singletons born after fresh or vitrified-warmed single blastocyst transfer (SBT). Singleton live births resulting from SBT of fresh or vitrified-warmed embryos were compared. Primary outcomes were perinatal outcomes including small for gestational age (SGA), low birthweight, preterm deliveries (PTD), large for gestational age (LGA) and congenital malformations...
April 6, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28412362/probing-the-acidic-residue-within-the-integrin-binding-site-of-laminin-511-that-interacts-with-the-metal-ion-dependent-adhesion-site-of-%C3%AE-6%C3%AE-1-integrin
#19
Yukimasa Taniguchi, Shaoliang Li, Mamoru Takizawa, Eriko Oonishi, Junko Toga, Emiko Yagi, Kiyotoshi Sekiguchi
Laminins are major cell-adhesive proteins of basement membranes that interact with integrins in a divalent cation-dependent manner. Laminin-511 consists of α5, β1, and γ1 chains, of which three laminin globular domains of the α5 chain (α5/LG1-3) and a Glu residue in the C-terminal tail of chain γ1 (γ1-Glu1607) are required for binding to integrins. However, it remains unsettled whether the Glu residue in the γ1 tail is involved in integrin binding by coordinating the metal ion in the metal ion-dependent adhesion site of β1 integrin (β1-MIDAS), or by stabilizing the conformation of α5/LG1-3...
June 3, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28410906/angular-pregnancy-interstitial-pregnancy-caesarean-scar-pregnancy-and-multidose-methotrexate
#20
EDITORIAL
Togas Tulandi
No abstract text is available yet for this article.
April 11, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
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