keyword
https://read.qxmd.com/read/37035110/phyto-assisted-synthesis-of-zinc-oxide-nanoparticles-for-developing-antibiofilm-surface-coatings-on-central-venous-catheters
#21
JOURNAL ARTICLE
Akshit Malhotra, Suchitra Rajput Chauhan, Mispaur Rahaman, Ritika Tripathi, Manika Khanuja, Ashwini Chauhan
Medical devices such as Central Venous Catheters (CVCs), are routinely used in intensive and critical care settings. In the present scenario, incidences of Catheter-Related Blood Stream Infections (CRBSIs) pose a serious challenge. Despite considerable advancements in the antimicrobial therapy and material design of CVCs, clinicians continue to struggle with infection-related complications. These complications are often due colonization of bacteria on the surface of the medical devices, termed as biofilms, leading to infections...
2023: Frontiers in Chemistry
https://read.qxmd.com/read/36985281/short-peripheral-venous-catheters-contamination-and-the-dangers-of-bloodstream-infection-in-portugal-an-analytic-study
#22
JOURNAL ARTICLE
Nádia Osório, Vânia Oliveira, Maria Inês Costa, Paulo Santos-Costa, Beatriz Serambeque, Fernando Gama, David Adriano, João Graveto, Pedro Parreira, Anabela Salgueiro-Oliveira
Peripheral venous catheters (PVCs) are the most used vascular access devices in the world. However, failure rates remain considerably high, with complications such as PVC-related infections posing significant threats to patients' well-being. In Portugal, studies evaluating the contamination of these vascular medical devices and characterizing the associated microorganisms are scarce and lack insight into potential virulence factors. To address this gap, we analyzed 110 PVC tips collected in a large tertiary hospital in Portugal...
March 9, 2023: Microorganisms
https://read.qxmd.com/read/36978309/effect-of-quorum-sensing-molecule-farnesol-on-mixed-biofilms-of-candida-albicans-and-staphylococcus-aureus
#23
JOURNAL ARTICLE
Barbora Gaálová-Radochová, Samuel Kendra, Luisa Jordao, Laura Kursawe, Judith Kikhney, Annette Moter, Helena Bujdáková
The natural bioactive molecule farnesol (FAR) is widely studied mainly for its antibiofilm and antimicrobial properties. In addition, it increases the effectiveness of some antimicrobial substances, which makes it interesting for the development of combined therapy. In the present work, the effect of FAR either alone or in combination with oxacillin (OXA) on mixed biofilms formed by clinically relevant pathogens, Candida albicans and Staphylococcus aureus , was studied. S. aureus isolates used for biofilm formation originated from blood cultures and central venous catheters (CVC) were characterized in terms of antimicrobial resistance...
February 23, 2023: Antibiotics
https://read.qxmd.com/read/36812218/a-new-strategy-to-prevent-biofilm-and-clot-formation-in-medical-devices-the-use-of-atmospheric-non-thermal-plasma-assisted-deposition-of-silver-based-nanostructured-coatings
#24
JOURNAL ARTICLE
Tommaso Gallingani, Elisa Resca, Massimo Dominici, Giuliana Gavioli, Romolo Laurita, Anna Liguori, Giorgio Mari, Luca Ortolani, Eva Pericolini, Arianna Sala, Giulia Laghi, Tiziana Petrachi, Gaëlle Francoise Arnauld, Luca Accorsi, Rita Rizzoli, Vittorio Colombo, Matteo Gherardi, Elena Veronesi
In industrialized countries, health care associated infections, the fourth leading cause of disease, are a major health issue. At least half of all cases of nosocomial infections are associated with medical devices. Antibacterial coatings arise as an important approach to restrict the nosocomial infection rate without side effects and the development of antibiotic resistance. Beside nosocomial infections, clot formation affects cardiovascular medical devices and central venous catheters implants. In order to reduce and prevent such infection, we develop a plasma-assisted process for the deposition of nanostructured functional coatings on flat substrates and mini catheters...
2023: PloS One
https://read.qxmd.com/read/36675901/-candida-parapsilosis-virulence-and-antifungal-resistance-mechanisms-a-comprehensive-review-of-key-determinants
#25
REVIEW
Joana Branco, Isabel M Miranda, Acácio G Rodrigues
Candida parapsilosis is the second most common Candida species isolated in Asia, Southern Europe, and Latin America and is often involved in invasive infections that seriously impact human health. This pathogen is part of the psilosis complex, which also includes Candida orthopsilosis and Candida metapsilosis. C. parapsilosis infections are particularly prevalent among neonates with low birth weights, individuals who are immunocompromised, and patients who require prolonged use of a central venous catheter or other indwelling devices, whose surfaces C...
January 5, 2023: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/36675063/effect-of-antibiotic-exposure-on-staphylococcus-epidermidis-responsible-for-catheter-related-bacteremia
#26
JOURNAL ARTICLE
Cassandra Pouget, Clotilde Chatre, Jean-Philippe Lavigne, Alix Pantel, Jacques Reynes, Catherine Dunyach-Remy
Coagulase-negative staphylococci (CoNS) and especially Staphylococcus epidermidis are responsible for health care infections, notably in the presence of foreign material (e.g., venous or central-line catheters). Catheter-related bacteremia (CRB) increases health care costs and mortality. The aim of our study was to evaluate the impact of 15 days of antibiotic exposure (ceftobiprole, daptomycin, linezolid and vancomycin) at sub-inhibitory concentration on the resistance, fitness and genome evolution of 36 clinical strains of S...
January 12, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36631973/role-of-short-dwell-daily-ethanol-lock-therapy-in-the-management-of-hemodialysis-tunneled-cuffed-catheter-related-bloodstream-infection
#27
JOURNAL ARTICLE
Sishir Gang, Abhijit Konnur, Mohan Rajapurkar, Umapati Hegde, Hardik Patel, Jigar Patel, Nitiraj Shete
BACKGROUND: Catheter-Related Blood Stream Infection (CRBSI) is the major limitation of using Tunneled cuffed catheter (TCC) for long-term Hemodialysis. The standard therapy of CRBSI involves systemic antibiotics with catheter replacement/removal. As antibiotic alone is rarely effective therapy for CRBSI, biofilm eradication using antimicrobial locking solutions is a promising modality for CRBSI treatment, hence catheter salvage. The present study evaluated the efficacy and safety of Ethanol-lock therapy (ELT) in combination with systemic antibiotics for the management of CRBSI associated with hemodialysis TCC...
January 11, 2023: Journal of Vascular Access
https://read.qxmd.com/read/36602372/-in-vivo-effectiveness-of-several-antimicrobial-locks-to-eradicate-intravascular-catheter-coagulase-negative-staphylococci-biofilms
#28
JOURNAL ARTICLE
Andrés Blanco-Di Matteo, Nuria Garcia-Fernandez, Aitziber Aguinaga Pérez, Francisco Carmona-Torre, Amaya C Oteiza, José Leiva, José Luis Del Pozo
Tunneled central venous catheter (TCVC) related infection remains a challenge in the care of hemodialysis patients. We aimed to determine the best antimicrobial lock therapy (ALT) to eradicate coagulase-negative staphylococci (CoNS) biofilms. We studied the colonization status of the catheter every 30 days by quantitative blood cultures (QBC) drawn through all catheter lumens. Those patients with a significant culture (i.e.,100 to 1,000 CFU/mL) of a CoNS were classified as patients with a high risk of developing catheter-related bloodstream infections (CRBSI)...
January 24, 2023: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/36551349/pre-emptive-antimicrobial-locks-decrease-long-term-catheter-related-bloodstream-infections-in-hemodialysis-patients
#29
JOURNAL ARTICLE
Andres Blanco-Di Matteo, Nuria Garcia-Fernandez, Aitziber Aguinaga Pérez, Francisco Carmona-Torre, Amaya C Oteiza, Jose Leiva, Jose Luis Del Pozo
This study aimed to prove that pre-emptive antimicrobial locks in patients at risk of bacteremia decrease infection. We performed a non-randomized prospective pilot study of hemodialysis patients with tunneled central venous catheters. We drew quantitative blood cultures monthly to detect colonization. Patients with a critical catheter colonization by coagulase-negative staphylococci (defined as counts of 100-999 CFU/mL) were at high risk of developing a catheter-related bloodstream infection. We recommended antimicrobial lock for this set of patients...
November 24, 2022: Antibiotics
https://read.qxmd.com/read/36518176/biofilm-forming-microorganisms-causing-hospital-acquired-infections-from-intravenous-catheter-a-systematic-review
#30
JOURNAL ARTICLE
Sandra Pamela Cangui-Panchi, Anahí Lizbeth Ñacato-Toapanta, Leonardo Joshué Enríquez-Martínez, Jorge Reyes, Daniel Garzon-Chavez, António Machado
The high prevalence of nosocomial infections is related to the use of medical insertion devices such as central venous catheters (CVCs). Most of the microorganisms causing nosocomial infections are biofilm producers, this characteristic allows them to adhere to abiotic surfaces and cause initial catheter infections that can lead to bloodstream infections. Our main goal in this systematic review was to evaluate the prevalence of biofilm among CVC-related infections, particularly among Intensive Care Unit (ICU) patients, in the studies applying different in vitro and in vivo methodologies...
2022: Current research in microbial sciences
https://read.qxmd.com/read/36494632/biofilm-infection-of-a-central-venous-port-catheter-caused-by-mycobacterium-avium-complex-in-an-immunocompetent-child-with-cystic-fibrosis
#31
JOURNAL ARTICLE
Alexandra Kavvalou, Florian Stehling, Eva Tschiedel, Jan Kehrmann, Bernd Walkenfort, Mike Hasenberg, Margarete Olivier, Mathis Steindor
BACKGROUND: Mycobacterium (M.) chimaera is a non-tuberculous mycobacterium (NTM) that belongs to M. avium complex (MAC). In patients with cystic fibrosis (CF), MAC can cause bronchopulmonary infections that can be prolonged and difficult to treat. MAC infections of sites other than the lungs or central catheters are rare and almost exclusively associated with immunodeficiency. CASE PRESENTATION: We present a case of an 8-year-old CF patient (delF508 homozygous) with recurrent pulmonary exacerbations, gradual clinical deterioration, B-symptoms (fever, fatigue, weight loss, night sweat), elevated transaminases and intermittent detection of M...
December 9, 2022: BMC Infectious Diseases
https://read.qxmd.com/read/36400647/biofilm-formation-and-antibiotic-resistance-among-coagulase-negative-staphylococcus-species-isolated-from-central-venous-catheters-of-intensive-care-unit-patients
#32
JOURNAL ARTICLE
Sohani Medis, Thushari Dissanayake, Jananie Kottahachchi, Dhananja Namali, Samanmalee Gunasekara, Gayan Wijesinghe, Niluka Dilrukshi, Manjula Weerasekera
PURPOSE: This study was conducted to determine the biofilm formation of coagulase negative Staphylococcus species (CoNS) isolated from patients with catheter related blood stream infection (CRBSI) and colonized central venous catheters (CVC) and their antibiotic susceptibility patterns and in situ biofilm formation of CVC tips. METHODS: Eighty-two CoNS isolated from intensive care unit (ICU) patients with CRBSI (n ​= ​8) or colonized CVC (n ​= ​74) were included...
November 15, 2022: Indian Journal of Medical Microbiology
https://read.qxmd.com/read/36347383/in-vitro-ability-of-fusarium-keratoplasticum-to-form-biofilms-in-venous-catheter
#33
JOURNAL ARTICLE
Alana Salvador, Flávia Franco Veiga, Terezinha Inez Estivalet Svidzinski, Melyssa Negri
Fusarium keratoplasticum is a common specie in human infections and is responsible for many diseases affecting immunocompetent and immunocompromised patients. This study aimed to evaluate the ability of Fusarium keratoplasticum to form biofilm in venous catheters (VC), focusing on the development of maturation and dispersion over time (24, 48, 72, 96 and 120 hours) and the evaluation amphotericin B (AB) susceptibility in planktonic cells and after 96 h of biofilm formation. F. keratoplasticum was able to form a biofilm in VC with maturation most likely between 48 and 72 h, according to colony count and total biomass results...
November 5, 2022: Microbial Pathogenesis
https://read.qxmd.com/read/36250821/molecular-study-of-accessory-gene-regulator-in-staphylococcus-aureus-isolated-from-sepsis-in-pediatric-patients
#34
JOURNAL ARTICLE
Mervat Mashaly, Asmaa Bakr, Eman A Elmansoury, Maysaa El S Zaki, Sara Galeb
BACKGROUND: Pediatric sepsis due to Staphylococcus aureus (S. aureus) is associated with high morbidity and mortality. Accessory-Gene-Regulator (agr) has a role in the pathogenesis of S. aureus through controlling and regulating the expression of virulence genes. Therefore, the aim of the present study was to investigate the prevalence of genotypes of the agr system in S. aureus isolated from children with sepsis and to assess their relationship to biofilm formation and antibiotic resistance...
October 1, 2022: Clinical Laboratory
https://read.qxmd.com/read/36190404/-in-vitro-and-in-vivo-antimicrobial-activity-of-hypochlorous-acid-against-drug-resistant-and-biofilm-producing-strains
#35
JOURNAL ARTICLE
Marta Palau, Estela Muñoz, Enric Lujan, Nieves Larrosa, Xavier Gomis, Ester Márquez, Oscar Len, Benito Almirante, Jordi Abellà, Sergi Colominas, Joan Gavaldà
The aims of this study were as follows. First, we determined the antimicrobial efficacy of hypochlorous acid (HClO) against bacterial, fungal, and yeast strains growing planktonically and growing in biofilms. Second, we sought to compare the activity of the combination of daptomycin and HClO versus those of the antimicrobial agents alone for the treatment of experimental catheter-related Staphylococcus epidermidis infection (CRI) using the antibiotic lock technique (ALT) in a rabbit model. HClO was generated through direct electric current (DC) shots at determined amperages and times...
October 26, 2022: Microbiology Spectrum
https://read.qxmd.com/read/36145584/assuring-the-biofunctionalization-of-silicone-covalently-bonded-to-rhamnolipids-antibiofilm-activity-and-biocompatibility
#36
JOURNAL ARTICLE
Maïssa Dardouri, Ana Bettencourt, Victor Martin, Filomena A Carvalho, Bruno Colaço, Adelina Gama, Madeleine Ramstedt, Nuno C Santos, Maria H Fernandes, Pedro S Gomes, Isabel A C Ribeiro
Silicone-based medical devices composed of polydimethylsiloxane (PDMS) are widely used all over the human body (e.g., urinary stents and catheters, central venous catheters stents) with extreme clinical success. Nevertheless, their abiotic surfaces, being prone to microorganism colonization, are often involved in infection occurrence. Improving PDMS antimicrobial properties by surface functionalization with biosurfactants to prevent related infections has been the goal of different works, but studies that mimic the clinical use of these novel surfaces are missing...
August 31, 2022: Pharmaceutics
https://read.qxmd.com/read/36140024/antimicrobial-resistance-and-biofilms-underlying-catheter-related-bloodstream-coinfection-by-enterobacter-cloacae-complex-and-candida-parapsilosis
#37
JOURNAL ARTICLE
Matúš Štefánek, Sigurd Wenner, Vítor Borges, Miguel Pinto, João Paulo Gomes, João Rodrigues, Isabel Faria, Maria Ana Pessanha, Filomena Martins, Raquel Sabino, Cristina Veríssimo, Isabel D Nogueira, Patrícia Almeida Carvalho, Helena Bujdáková, Luisa Jordao
Biofilm-associated infections are a public health concern especially in the context of healthcare-associated infections such as catheter-related bloodstream infections (CRBSIs). We evaluated the biofilm formation and antimicrobials resistance (AMR) of Enterobacter cloacae complex and Candida parapsilosis co-isolated from a CRBSI patient. Antimicrobial susceptibility of central venous catheters (CVCs) and hemoculture (HC) isolates was evaluated, including whole genome sequencing (WGS) resistome analysis and evaluation of gene expression to obtain insight into their AMR determinants...
September 14, 2022: Antibiotics
https://read.qxmd.com/read/36042488/control-of-line-complications-with-kitelock-click-in-the-critical-care-unit-study-protocol-for-a-multi-center-cluster-randomized-double-blinded-crossover-trial-investigating-the-effect-of-a-novel-locking-fluid-on-central-line-complications-in-the-critical-care
#38
JOURNAL ARTICLE
Marlena Ornowska, Hubert Wong, Yongdong Ouyang, Anish Mitra, Aaron White, Sue Willems, Jessica Wittmann, Steven Reynolds
BACKGROUND: Insertion of a central venous access device (CVAD) allows clinicians to easily access the circulation of a patient to administer life-saving interventions. Due to their invasive nature, CVADs are prone to complications such as bacterial biofilm production and colonization, catheter-related bloodstream infection, occlusion, and catheter-related venous thrombosis. A CVAD is among the most common interventions for patients in the intensive care unit (ICU), exposing this vulnerable population to the risk of nosocomial infection and catheter occlusion...
August 30, 2022: Trials
https://read.qxmd.com/read/35964484/biofilm-formation-on-central-venous-catheters-a-pilot-study
#39
JOURNAL ARTICLE
Britney Niemann, Lauren Dudas, Dana Gray, Andrea Pettit, Alison Wilson, James M Bardes
INTRODUCTION: Central line-associated bloodstream infection is a complication with serious consequences and biofilm development is thought to play a role. This study evaluated the impact of sterilization technique on central venous catheter (CVC) biofilm formation. MATERIALS AND METHODS: This pilot study was conducted in the surgical intensive care unit of a tertiary care facility. All CVCs were inserted with chlorhexidine preparation (CHG). CHG-only CVCs were compared to the use of CHG with chlorhexidine gluconate-impregnated sponge (CHGIS)...
August 11, 2022: Journal of Surgical Research
https://read.qxmd.com/read/35960241/-investigation-of-biofilm-formation-properties-of-coagulase-negative-staphylococci-isolated-from-catheter-related-bloodstream-infections
#40
JOURNAL ARTICLE
Duygu Öcal, Alper Tekeli, İştar Dolapçı
In view of the significant negative impact of biofilm-mediated infection on patient health and the necessity of a reliable phenotypic method to detect biofilm producers, this study aimed to demonstrate phenotypic and molecular biofilm formation in coagulase-negative staphylococci (CoNS) isolated from catheter related infections and to compare the methods used with each other. The study was also aimed to determine the biofilm eradication effect of vancomycin in order to guide for the treatment. For the detection of biofilm formation, a total of 154 CoNS clinical isolates of which 30 being causative agents of catheter related bloodstream infection (CRBSI) (isolated from both the catheter tip and blood cultures of 15 patients), 89 being isolated from peripheral blood cultures of patients without a central venous catheter (CVC) (13 of them were bloodstream infection agents, 76 of them were contaminant), and 35 being isolated as catheter colonizer, were screened by tissue culture plate (TCP), Congo red agar (CRA) method and polymerase chain reaction (icaA, icaD and IS256)...
July 2022: Mikrobiyoloji Bülteni
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