keyword
https://read.qxmd.com/read/38698921/bioinspired-super-hydrophilic-zwitterionic-polymer-armor-combats-thrombosis-and-infection-of-vascular-catheters
#1
JOURNAL ARTICLE
You Ke, Haotian Meng, Zeyu Du, Wentai Zhang, Qing Ma, Yuting Huang, Linxian Cui, Yifeng Lei, Zhilu Yang
Thrombosis and infection are two major complications associated with central venous catheters (CVCs), which significantly contribute to morbidity and mortality. Antifouling coating strategies currently represent an efficient approach for addressing such complications. However, existing antifouling coatings have limitations in terms of both duration and effectiveness. Herein, we propose a durable zwitterionic polymer armor for catheters. This armor is realized by pre-coating with a robust phenol-polyamine film inspired by insect sclerotization, followed by grafting of poly-2-methacryloyloxyethyl phosphorylcholine (pMPC) via in-situ radical polymerization...
July 2024: Bioactive Materials
https://read.qxmd.com/read/38695568/micrococcal-nuclease-regulates-biofilm-formation-and-dispersal-in-methicillin-resistant-staphylococcus-aureus-usa300
#2
JOURNAL ARTICLE
Jeffrey B Kaplan, Alexander R Horswill
Biofilm formation is an important virulence factor for methicillin-resistant Staphylococcus aureus (MRSA). The extracellular matrix of MRSA biofilms contains significant amounts of double-stranded DNA that hold the biofilm together. MRSA cells secrete micrococcal nuclease (Nuc1), which degrades double-stranded DNA. In this study, we used standard methodologies to investigate the role of Nuc1 in MRSA biofilm formation and dispersal. We quantified biofilm formation and extracellular DNA (eDNA) levels in broth and agar cultures...
May 2, 2024: MSphere
https://read.qxmd.com/read/38695226/-cuff-shaving-in-recurrent-exit-site-infections-in-a-patient-on-peritoneal-dialysis
#3
JOURNAL ARTICLE
Vincenzo Cosentini, Sabina Rognini, Lina Giannella Mantovani, Laura Zennari, Alireza Hasheminia, Ivano Dal Dosso, Linda Gammaro
In patients on peritoneal dialysis, the cutaneous emergency (exit-site) represents a potential access route to the peritoneum; consequently, it can become a site for microbial infections. These infections, initially localized to the exit-site, may spread to the peritoneum causing peritonitis, which is the most common cause of drop-out from peritoneal dialysis and transition to hemodialysis. Peritoneal catheters have dacron caps which have the function of counteracting the traction of the catheter itself and at the same time acting as a barrier for microorganisms, preventing the spread towards the peritoneum...
April 29, 2024: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://read.qxmd.com/read/38692146/in-vitro-models-for-studying-implant-associated-biofilms-a-review-from-the-perspective-of-bioengineering-3d-microenvironments
#4
REVIEW
Silvia Cometta, Dietmar W Hutmacher, Liraz Chai
Biofilm research has grown exponentially over the last decades, arguably due to their contribution to hospital acquired infections when they form on foreign body surfaces such as catheters and implants. Yet, translation of the knowledge acquired in the laboratory to the clinic has been slow and/or often it is not attempted by research teams to walk the talk of what is defined as 'bench to bedside'. We therefore reviewed the biofilm literature to better understand this gap. Our search revealed substantial development with respect to adapting surfaces and media used in models to mimic the clinical settings, however many of the in vitro models were too simplistic, often discounting the composition and properties of the host microenvironment and overlooking the biofilm-implant-host interactions...
April 20, 2024: Biomaterials
https://read.qxmd.com/read/38681224/exploration-of-agr-types-virulence-associated-genes-and-biofilm-formation-ability-in-staphylococcus-aureus-isolates-from-hemodialysis-patients-with-vascular-access-infections
#5
JOURNAL ARTICLE
Chi-Hsiang Lai, Min Yi Wong, Tsung-Yu Huang, Chih-Chen Kao, Yu-Hui Lin, Chu-Hsueh Lu, Yao-Kuang Huang
INTRODUCTION: Staphylococcus aureus , is a pathogen commonly encountered in both community and hospital settings. Patients receiving hemodialysis treatment face an elevated risk of vascular access infections (VAIs) particularly Staphylococcus aureus , infection. This heightened risk is attributed to the characteristics of Staphylococcus aureus , , enabling it to adhere to suitable surfaces and form biofilms, thereby rendering it resistant to external interventions and complicating treatment efforts...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38667964/combination-of-systemic-and-lock-therapies-with-micafungin-eradicate-catheter-based-biofilms-and-infections-caused-by-candida-albicans-and-candida-parapsilosis-in-neutropenic-rabbit-models
#6
JOURNAL ARTICLE
Ruta Petraitiene, Vidmantas Petraitis, Myo H Zaw, Kaiser Hussain, Rodolfo J Ricart Arbona, Emanuel Roilides, Thomas J Walsh
Vascular catheter-related infections, primarily caused by Candida albicans and Candida parapsilosis , pose significant challenges due to the formation of biofilms on catheters, leading to refractory disease and considerable morbidity. We studied the efficacy of micafungin in systemic and lock therapies to eliminate catheter-based biofilms and deep tissue infections in experimental central venous catheter (CVC)-related candidemia in neutropenic rabbits. Silastic CVCs in rabbits were inoculated with 1 × 103 CFU/mL of C...
April 17, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38665376/antibiotic-lock-solutions-as-adjunct-therapy-for-catheter-related-blood-stream-infections-in-pediatric-hemodialysis-patients
#7
REVIEW
N Blair, P Patil, D Nguyen, B Paudyal-Nepal, F Iorember
The predominant use of intravenous catheters as primary access type in the pediatric hemodialysis population is associated with an increased risk of catheter related blood stream infections. While strict adherence to catheter placement and long-term care guidelines have helped to decrease the incidence of these infections, blood stream infections remain an infection burden in pediatric patients with long term hemodialysis catheters. The formation of biofilms on the surfaces of these catheters has been shown to be a source of microbes causing blood stream infections...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38646633/overview-of-proteus-mirabilis-pathogenicity-and-virulence-insights-into-the-role-of-metals
#8
REVIEW
Mohamed Chakkour, Zeinab Hammoud, Solay Farhat, Ali El Roz, Zeinab Ezzeddine, Ghassan Ghssein
Proteus mirabilis is a Gram-negative bacterium with exclusive molecular and biological features. It is a versatile pathogen acclaimed for its distinct urease production, swarming behavior, and rapid multicellular activity. Clinically, P. mirabilis is a frequent pathogen of the human urinary system where it causes urinary tract infections (UTIs) and catheter-associated urinary tract infections (CAUTIs). This review explores the epidemiology, risk factors, clinical manifestations, and treatment of P. mirabilis infections, emphasizing its association with UTIs...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38617774/indwelling-pleural-catheter-infection-and-colonisation-a-clinical-practice-review
#9
REVIEW
Dheeraj K Sethi, Mark A Webber, Eleanor K Mishra
Indwelling pleural catheters (IPCs) are used in the management of malignant pleural effusions, but they can become infected in 5.7% of cases. This review aims to provide a summary of the development of IPC infections and their microbiology, diagnosis and management. IPC infections can be deep, involving the pleural space, or superficial. The former are of greater clinical concern. Deep infection is associated with biofilm formation on the IPC surface and require longer courses of antibiotic treatment. Mortality from infections is low and it is common for patients to undergo pleurodesis following a deep infection...
March 29, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38587399/a-catheter-related-candida-albicans-infection-model-in-mouse
#10
JOURNAL ARTICLE
Chen Yang, Fei Mo, Jiaxue Zhang, Peipei Zhang, Qingqing Li, Jiye Zhang
Catheter-related infection (CRI) is a common nosocomial infection caused by candida albicans during catheter implantation. Typically, biofilms are formed on the outer surface of the catheter and lead to disseminated infections, which are fatal to patients. There are no effective prevention and treatment management in clinics. Therefore, it is urgent to establish an animal model of CRI for the preclinical screening of new strategies for its prevention and treatment. In this study, a polyethylene catheter, a widely used medical catheter, was inserted into the back of the BALB/c mice after hair removal...
March 22, 2024: Journal of Visualized Experiments: JoVE
https://read.qxmd.com/read/38567642/cxcr2-perturbation-promotes-staphylococcus-aureus-implant-associated-infection
#11
JOURNAL ARTICLE
Mike Akaraphanth, Tara M Nordgren, Casey M Gries
Introduction. Staphylococcus aureus is the leading cause of acute medical implant infections, representing a significant modern medical concern. The success of S. aureus as a pathogen in these cases resides in its arsenal of virulence factors, resistance to multiple antimicrobials, mechanisms of immune modulation, and ability to rapidly form biofilms associated with implant surfaces. S. aureus device-associated, biofilm-mediated infections are often persistent and notoriously difficult to treat, skewing innate immune responses to promote chronic reoccurring infections...
April 2024: Journal of Medical Microbiology
https://read.qxmd.com/read/38562859/functional-redundancy-in-candida-auris-cell-surface-adhesins-crucial-for-cell-cell-interaction-and-aggregation
#12
Mary Ann Jabra-Rizk, Tristan Wang, Dimitrios Sofras, Daniel Montelongo-Jauregui, Telmo Paiva, Hans Carolus, Yves Dufrene, Areej Alfaifi, Carrie McCracken, Vincent Bruno, Patrick Van Dijck
Candida auris is an emerging nosocomial fungal pathogen associated with life-threatening invasive disease due to its persistent colonization, high level of transmissibility and multi-drug resistance. Aggregative and non-aggregative growth phenotypes for C. auris strains with different biofilm forming abilities, drug susceptibilities and virulence characteristics have been described. Using comprehensive transcriptional analysis we identified key cell surface adhesins that were highly upregulated in the aggregative phenotype during in vitro and in vivo grown biofilms using a mouse model of catheter infection...
March 22, 2024: Research Square
https://read.qxmd.com/read/38562758/functional-redundancy-in-candida-auris-cell-surface-adhesins-crucial-for-cell-cell-interaction-and-aggregation
#13
Tristan W Wang, Dimitrios Sofras, Daniel Montelongo-Jauregui, Telmo O Paiva, Hans Carolus, Yves F Dufrêne, Areej A Alfaifi, Carrie McCracken, Vincent M Bruno, Patrick Van Dijck, Mary Ann Jabra-Rizk
Candida auris is an emerging nosocomial fungal pathogen associated with life-threatening invasive disease due to its persistent colonization, high level of transmissibility and multi-drug resistance. Aggregative and non-aggregative growth phenotypes for C. auris strains with different biofilm forming abilities, drug susceptibilities and virulence characteristics have been described. Using comprehensive transcriptional analysis we identified key cell surface adhesins that were highly upregulated in the aggregative phenotype during in vitro and in vivo grown biofilms using a mouse model of catheter infection...
March 21, 2024: bioRxiv
https://read.qxmd.com/read/38552533/a-comparative-study-on-antibiotic-resistant-escherichia-coli-isolates-from-austrian-patients-and-wastewater-influenced-danube-river-water-and-biofilms
#14
REVIEW
Melanie Leopold, Angelika Kabicher, Ildiko-Julia Pap, Barbara Ströbele, Gernot Zarfel, Andreas H Farnleitner, Alexander K T Kirschner
Antimicrobial resistance (AMR) poses a major threat to human health worldwide. AMR can be introduced into natural aquatic ecosystems, for example, from clinical facilities via wastewater emissions. Understanding AMR patterns in environmental populations of bacterial pathogens is important to elucidate propagation routes and develop mitigation strategies. In this study, AMR patterns of Escherichia coli isolates from urinary tract infections and colonised urinary catheters of inpatients and outpatients were compared to isolates from the Danube River within the same catchment in Austria to potentially link environmental with clinical resistance patterns...
March 28, 2024: International Journal of Hygiene and Environmental Health
https://read.qxmd.com/read/38538626/fibrinolytic-deficiencies-predispose-hosts-to-septicemia-from-a-catheter-associated-uti
#15
JOURNAL ARTICLE
Jonathan J Molina, Kurt N Kohler, Christopher Gager, Marissa J Andersen, Ellsa Wongso, Elizabeth R Lucas, Andrew Paik, Wei Xu, Deborah L Donahue, Karla Bergeron, Aleksandra Klim, Michael G Caparon, Scott J Hultgren, Alana Desai, Victoria A Ploplis, Matthew J Flick, Francis J Castellino, Ana L Flores-Mireles
Catheter-associated urinary tract infections (CAUTIs) are amongst the most common nosocomial infections worldwide and are difficult to treat partly due to development of multidrug-resistance from CAUTI-related pathogens. Importantly, CAUTI often leads to secondary bloodstream infections and death. A major challenge is to predict when patients will develop CAUTIs and which populations are at-risk for bloodstream infections. Catheter-induced inflammation promotes fibrinogen (Fg) and fibrin accumulation in the bladder which are exploited as a biofilm formation platform by CAUTI pathogens...
March 27, 2024: Nature Communications
https://read.qxmd.com/read/38535596/the-influence-of-l-lysine-alpha-oxidase-on-the-biofilm-formation-of-opportunistic-microorganisms-associated-with-inflammatory-diseases-of-the-urinary-tract
#16
JOURNAL ARTICLE
Alexandr Senyagin, Nadezhda Sachivkina, Milana Das, Anna Arsenyuk, Ramziya Mannapova, Alfir Mannapov, Tursumbai Kubatbekov, Dmitriy Svistunov, Olesya Petrukhina, Andrey Zharov, Natallia Zhabo
Urinary tract infections occupy a special niche among diseases of infectious etiology. Many microorganisms associated with urinary tract infections, such as Klebsiella oxytoca , Enterococcus spp., Morganella morganii , Moraxella catarrhalis , Pseudomonas aeruginosa , Proteus mirabilis , Staphylococcus aureus , Staphylococcus spp., and Candida spp., can form biofilms. The aim of this research was to study the effect of the enzyme L-lysine-Alpha-oxidase (LO) produced by the fungus Trichoderma harzianum Rifai on the biofilm formation process of microorganisms associated with urinary tract infections...
March 15, 2024: Pathogens
https://read.qxmd.com/read/38526664/cuminaldehyde-and-tobramycin-forestall-the-biofilm-threats-of-staphylococcus-aureus-a-combinatorial-strategy-to-evade-the-biofilm-challenges
#17
JOURNAL ARTICLE
Ritwik Roy, Payel Paul, Poulomi Chakraborty, Moumita Malik, Sharmistha Das, Sudipta Chatterjee, Alakesh Maity, Monikankana Dasgupta, Ranojit Kumar Sarker, Sarita Sarkar, Anirban Das Gupta, Prosun Tribedi
Staphylococcus aureus, an opportunistic Gram-positive pathogen, is known for causing various infections in humans, primarily by forming biofilms. The biofilm-induced antibiotic resistance has been considered a significant medical threat. Combinatorial therapy has been considered a reliable approach to combat antibiotic resistance by using multiple antimicrobial agents simultaneously, targeting bacteria through different mechanisms of action. To this end, we examined the effects of two molecules, cuminaldehyde (a natural compound) and tobramycin (an antibiotic), individually and in combination, against staphylococcal biofilm...
March 25, 2024: Applied Biochemistry and Biotechnology
https://read.qxmd.com/read/38510214/a-review-on-antimicrobial-strategies-in-mitigating-biofilm-associated-infections-on-medical-implants
#18
REVIEW
Lohita Kadirvelu, Sowmiya Sri Sivaramalingam, Deepsikha Jothivel, Dhivia Dharshika Chithiraiselvan, Deenadayalan Karaiyagowder Govindarajan, Kumaravel Kandaswamy
Biomedical implants are crucial in providing support and functionality to patients with missing or defective body parts. However, implants carry an inherent risk of bacterial infections that are biofilm-associated and lead to significant complications. These infections often result in implant failure, requiring replacement by surgical restoration. Given these complications, it is crucial to study the biofilm formation mechanism on various biomedical implants that will help prevent implant failures. Therefore, this comprehensive review explores various types of implants (e...
2024: Current research in microbial sciences
https://read.qxmd.com/read/38506890/risk-of-infections-related-to-endovascular-catheters-and-cardiac-implantable-devices-in-hemodialysis-patients
#19
REVIEW
Gaetano Alfano, Niccolò Morisi, Silvia Giovanella, Monica Frisina, Alessio Amurri, Lorenzo Tei, Maria Ferri, Giulia Ligabue, Gabriele Donati
Patients requiring dialysis are extremely vulnerable to infectious diseases. The high burden of comorbidities and weakened immune system due to uremia and previous immunosuppressive therapy expose the patient on dialysis to more infectious events than the general population. The infectious risk is further increased by the presence of endovascular catheters and implantable cardiologic devices. The former is generally placed as urgent vascular access for dialysis and in subjects requiring hemodialysis treatments without autogenous arteriovenous fistula...
March 20, 2024: Journal of Vascular Access
https://read.qxmd.com/read/38500503/phage-p2-71-against-multi-drug-resistant-proteus-mirabilis-isolation-characterization-and-non-antibiotic-antimicrobial-potential
#20
JOURNAL ARTICLE
Zhiyou Dong, Ruihu Wu, Lijuan Liu, Shengquan Ai, Jinpeng Yang, Qianlan Li, Keyi Fu, Yunian Zhou, Hualin Fu, Ziyao Zhou, Haifeng Liu, Zhijun Zhong, Xianmeng Qiu, Guangneng Peng
Proteus mirabilis , a prevalent urinary tract pathogen and formidable biofilm producer, especially in Catheter-Associated Urinary Tract Infection, has seen a worrying rise in multidrug-resistant (MDR) strains. This upsurge calls for innovative approaches in infection control, beyond traditional antibiotics. Our research introduces bacteriophage (phage) therapy as a novel non-antibiotic strategy to combat these drug-resistant infections. We isolated P2-71, a lytic phage derived from canine feces, demonstrating potent activity against MDR P...
2024: Frontiers in Cellular and Infection Microbiology
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