Francieli Gesleine Capote Bonato, Denis Vinicius Bonato, Ilan Munhoz Ayer, Larissa Fernandes Magalhães, Geórgia Modé Magalhães, Felipe Farias Pereira da Câmara Barros, Pedro Paulo Maia Teixeira, Leandro Zuccolotto Crivellenti, Melyssa Negri, Terezinha Inez Estivalet Svidzinski
To evaluate the pathophysiology of catheter-associated candiduria, the bladders of female mice were infected with Candida tropicalis. One group was implanted with a catheter fragment with preformed biofilm by cystotomy technique, while another group received, in separate, a sterile catheter fragment and a correspondent yeast suspension. The bladder tissues were examined by histopathology and the quantity of colony forming units was evaluated. All the animals presented inflammation and the presence of C. tropicalis was observed in the tissue within 72 h of the introduction of biofilm, while 75% of the mice remained infected after 144 h...
February 19, 2018: Microbial Pathogenesis